KR930701487A - 식물성 독소 겔로닌의 단백질 구조물 - Google Patents

식물성 독소 겔로닌의 단백질 구조물

Info

Publication number
KR930701487A
KR930701487A KR1019930700412A KR930700412A KR930701487A KR 930701487 A KR930701487 A KR 930701487A KR 1019930700412 A KR1019930700412 A KR 1019930700412A KR 930700412 A KR930700412 A KR 930700412A KR 930701487 A KR930701487 A KR 930701487A
Authority
KR
South Korea
Prior art keywords
gelonin
fragments
dna
protein structure
derivatives
Prior art date
Application number
KR1019930700412A
Other languages
English (en)
Other versions
KR100220502B1 (ko
Inventor
로젠블룸 마이클
악가랄 브하라트
제이. 코어 윌리암
Original Assignee
제임스 에프,와일러
리서치 디벨롭먼트 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제임스 에프,와일러, 리서치 디벨롭먼트 파운데이션 filed Critical 제임스 에프,와일러
Publication of KR930701487A publication Critical patent/KR930701487A/ko
Application granted granted Critical
Publication of KR100220502B1 publication Critical patent/KR100220502B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Abstract

본 발명은 겔로닌 또는 세포성 단백질 합성을 억제하지만 세포 표면 수용체와 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 cDNA 및 아미노산 서열에 관한 것이다.

Description

식물성 독소 겔로닌의 단백질 구조물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 겔로닌의 아미노산 서열을 도시한다.
제2도는 겔로닌에 대한 cDNA 암호화를 나타낸다,
제3도는 겔로닌 아미노산 서열과 트리코산틴, 리신 A 쇄, 파마자로 부터 분리한 아글루티닌 전구체 및 아브린 A쇄의 서열가의 호몰로지(homology)를 나타낸다.

Claims (8)

  1. [1992년 2월 14일자로 국제사무국에 의해 수령됨 :최초 출원된 특허청구의 범위 제1항 및 제2항이 보정된 특허청구의 범위 제1항 및 제2항으로 대체됨]
  2. 세포성 단백질 합성을 억제하지만 세포 표면 수용체와는 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 하기 아미노산 서열을 갖는 실질적으로 순수한 겔로닌 독소, 이의 단편 및 유도체.
  4. 겔로닌을 암호화하거나 세포성 단백질 합성을 억제하지만 세포 표면 수용체와는 결합하지 않는 활성을 갖는 폴리펩타이드를 암호화하는 하기 서열식의 DNA, 이의 단편 및 유도체.
  7. 여기서, R은 A 또는 G이고, K는 G 또는 T이고, N은 모든 염기이고, Y는 C 또는 T이고, M은 A 또는 C이고, S는 C 또는 G이고, B는 C, G 또는 T이고, V는 A, C 또는 G이고, W는 A 또는 T이고, D는 A, G 또는 T이고, H는 A, C 또는 T이고, X는 미지의 염기이다.
  8. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930700412A 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물 KR100220502B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US7/567,220 1990-08-14
US07/567,220 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (2)

Publication Number Publication Date
KR930701487A true KR930701487A (ko) 1993-06-11
KR100220502B1 KR100220502B1 (ko) 1999-10-01

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700412A KR100220502B1 (ko) 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물

Country Status (22)

Country Link
US (2) US5631348A (ko)
EP (1) EP0546087B1 (ko)
JP (1) JPH06502847A (ko)
KR (1) KR100220502B1 (ko)
CN (1) CN1055123C (ko)
AT (1) ATE150791T1 (ko)
CA (1) CA2088068C (ko)
DE (1) DE69125381T2 (ko)
DK (1) DK0546087T3 (ko)
ES (1) ES2100960T3 (ko)
FI (1) FI112492B (ko)
GR (1) GR3023593T3 (ko)
HK (1) HK1006727A1 (ko)
IE (1) IE912716A1 (ko)
IL (1) IL99079A (ko)
NO (1) NO309656B1 (ko)
NZ (1) NZ239249A (ko)
PT (1) PT98669B (ko)
RU (1) RU2104285C1 (ko)
SA (1) SA92130322B1 (ko)
WO (1) WO1992003144A1 (ko)
ZA (1) ZA916171B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97776A (en) * 1990-04-19 2000-10-31 Res Dev Foundation Composition comprising a conjugate of a ZME antibody and a biological response modifier
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
DK0602144T3 (da) * 1991-09-06 1999-07-19 Res Dev Foundation DNA-Sekvenser, der koder for polypeptidet gelonin
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6146850A (en) 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
CA2139571C (en) * 1992-07-07 2006-11-14 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2004535202A (ja) * 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
CA2488858A1 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
US20060171919A1 (en) * 2005-02-01 2006-08-03 Research Development Foundation Targeted polypeptides
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
EP0341304A4 (en) 1987-11-24 1991-01-30 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
EP0546087A1 (en) 1993-06-16
EP0546087A4 (ko) 1994-01-05
NZ239249A (en) 1992-10-28
AU653365B2 (en) 1994-09-29
USRE37462E1 (en) 2001-12-04
CA2088068C (en) 1999-06-15
AU8624091A (en) 1992-03-17
CN1055123C (zh) 2000-08-02
PT98669A (pt) 1992-07-31
KR100220502B1 (ko) 1999-10-01
NO930428L (no) 1993-03-29
EP0546087B1 (en) 1997-03-26
CA2088068A1 (en) 1992-02-15
IL99079A0 (en) 1992-07-15
ATE150791T1 (de) 1997-04-15
DE69125381D1 (de) 1997-04-30
PT98669B (pt) 1999-01-29
NO309656B1 (no) 2001-03-05
RU2104285C1 (ru) 1998-02-10
IL99079A (en) 1998-09-24
US5631348A (en) 1997-05-20
CN1058990A (zh) 1992-02-26
SA92130322B1 (ar) 2004-05-25
WO1992003144A1 (en) 1992-03-05
JPH06502847A (ja) 1994-03-31
FI112492B (fi) 2003-12-15
IE912716A1 (en) 1992-02-26
GR3023593T3 (en) 1997-08-29
HK1006727A1 (en) 1999-03-12
ES2100960T3 (es) 1997-07-01
FI930626A (fi) 1993-02-12
DK0546087T3 (da) 1997-09-22
NO930428D0 (no) 1993-02-08
DE69125381T2 (de) 1997-07-03
FI930626A0 (fi) 1993-02-12
ZA916171B (en) 1992-04-29

Similar Documents

Publication Publication Date Title
KR930701487A (ko) 식물성 독소 겔로닌의 단백질 구조물
DK0758383T3 (da) Oplöselige polypeptidfraktioner af LAG-3-proteinet; fremgangsmåde til fremstilling; terapeutisk sammensætning; antiidiotypisk antistof
DK368588A (da) Bindingsmolekyler med en enkelt polypeptidkaede
ATE182901T1 (de) Für androgen-rezeptor-protein kodierende dna
FI895382A0 (fi) Uretan-skyddade aminosyra-n -karboxianhydrider.
ES2085993T3 (es) Proteina asociada a la pancreatitis aguda, medios para el diagnostico de la pancreatitis aguda.
ATE106943T1 (de) Variante cd44-oberflächenproteine, diese kodierende dna-sequenzen, antikörper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie.
KR980002066A (ko) 변이형 인간 성장호르몬 및 그의 용도
EA201001190A1 (ru) Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
DE69529674T2 (de) Biologisch aktive ligande der eph familie
ATE314474T1 (de) Klonering von dem gen für das t gondii protein gp 28.5 peptidfragmente aus diesem protein und ihre verwendungen.
ES2089784T3 (es) Expresion de estafilocinasas sin peptido de señal.
DE3782549D1 (de) Neue polypeptide, ihre herstellung und ihre verwendung.
SE8801723D0 (sv) Fibronectin binding protein as well as its preparation
ATE281519T1 (de) Klonierung und rekombinante herstellung des crf- rezeptors (crf=corticotropin ausloese faktor)
KR940008700A (ko) 사람형 모노클로날 항펩티드 항체 및 이것을 코드하는 dna
DE69731312D1 (de) Peptide spezifisch für antikörper gegen peptidconcensussequenzen aus der cs4-cfa/iprpteinfamilie

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20080619

Year of fee payment: 10

LAPS Lapse due to unpaid annual fee