ES2100960T3 - Estructura proteica de la toxina vegetal gelonina. - Google Patents

Estructura proteica de la toxina vegetal gelonina.

Info

Publication number
ES2100960T3
ES2100960T3 ES91917004T ES91917004T ES2100960T3 ES 2100960 T3 ES2100960 T3 ES 2100960T3 ES 91917004 T ES91917004 T ES 91917004T ES 91917004 T ES91917004 T ES 91917004T ES 2100960 T3 ES2100960 T3 ES 2100960T3
Authority
ES
Spain
Prior art keywords
gelonin
protein structure
dna
toxic fragments
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917004T
Other languages
English (en)
Inventor
Michael Rosenblum
Bharat Aggarwal
William J Kohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Development Foundation
Original Assignee
Research Development Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Application granted granted Critical
Publication of ES2100960T3 publication Critical patent/ES2100960T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE PRESENTA UN CDNA QUE CODIFICA UNA SECUENCIA DE AMINOACIDO PARA LA GELONINA O PARA UN POLIPEPTIDO QUE TENGA UNA ACTIVIDAD QUE INHIBA LA SINTESIS DE LA PROTEINA CELULAR PERO QUE NO SE UNA A UN RECEPTOR DE LA SUPERFICIE CELULAR.
ES91917004T 1990-08-14 1991-08-14 Estructura proteica de la toxina vegetal gelonina. Expired - Lifetime ES2100960T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14

Publications (1)

Publication Number Publication Date
ES2100960T3 true ES2100960T3 (es) 1997-07-01

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917004T Expired - Lifetime ES2100960T3 (es) 1990-08-14 1991-08-14 Estructura proteica de la toxina vegetal gelonina.

Country Status (22)

Country Link
US (2) US5631348A (es)
EP (1) EP0546087B1 (es)
JP (1) JPH06502847A (es)
KR (1) KR100220502B1 (es)
CN (1) CN1055123C (es)
AT (1) ATE150791T1 (es)
CA (1) CA2088068C (es)
DE (1) DE69125381T2 (es)
DK (1) DK0546087T3 (es)
ES (1) ES2100960T3 (es)
FI (1) FI112492B (es)
GR (1) GR3023593T3 (es)
HK (1) HK1006727A1 (es)
IE (1) IE912716A1 (es)
IL (1) IL99079A (es)
NO (1) NO309656B1 (es)
NZ (1) NZ239249A (es)
PT (1) PT98669B (es)
RU (1) RU2104285C1 (es)
SA (1) SA92130322B1 (es)
WO (1) WO1992003144A1 (es)
ZA (1) ZA916171B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA912490B (en) * 1990-04-19 1992-12-30 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
AU679427B2 (en) * 1991-09-06 1997-07-03 Research Development Foundation DNA sequences encoding gelonin polypeptide
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
CA2139571C (en) * 1992-07-07 2006-11-14 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
US7101977B2 (en) 2001-07-17 2006-09-05 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
AU2003275985A1 (en) * 2002-06-12 2003-12-31 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
JP2008528633A (ja) * 2005-02-01 2008-07-31 リサーチ ディベロップメント ファウンデーション Ｂｌｙｓレセプターを標的化するためのｂｌｙｓ融合タンパク質およびｂ細胞増殖性疾患の処置方法
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
WO1989004839A1 (en) 1987-11-24 1989-06-01 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
FI930626A (fi) 1993-02-12
NO309656B1 (no) 2001-03-05
DE69125381D1 (de) 1997-04-30
CN1055123C (zh) 2000-08-02
RU2104285C1 (ru) 1998-02-10
ZA916171B (en) 1992-04-29
SA92130322B1 (ar) 2004-05-25
EP0546087B1 (en) 1997-03-26
PT98669A (pt) 1992-07-31
DK0546087T3 (da) 1997-09-22
EP0546087A1 (en) 1993-06-16
WO1992003144A1 (en) 1992-03-05
CA2088068C (en) 1999-06-15
CN1058990A (zh) 1992-02-26
DE69125381T2 (de) 1997-07-03
PT98669B (pt) 1999-01-29
GR3023593T3 (en) 1997-08-29
NO930428L (no) 1993-03-29
CA2088068A1 (en) 1992-02-15
IE912716A1 (en) 1992-02-26
IL99079A (en) 1998-09-24
NZ239249A (en) 1992-10-28
HK1006727A1 (en) 1999-03-12
FI112492B (fi) 2003-12-15
AU653365B2 (en) 1994-09-29
ATE150791T1 (de) 1997-04-15
EP0546087A4 (es) 1994-01-05
KR930701487A (ko) 1993-06-11
USRE37462E1 (en) 2001-12-04
US5631348A (en) 1997-05-20
JPH06502847A (ja) 1994-03-31
IL99079A0 (en) 1992-07-15
KR100220502B1 (ko) 1999-10-01
AU8624091A (en) 1992-03-17
NO930428D0 (no) 1993-02-08
FI930626A0 (fi) 1993-02-12

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