KR910011896A - 신규한 글리코펩티드 유도체 - Google Patents
신규한 글리코펩티드 유도체 Download PDFInfo
- Publication number
- KR910011896A KR910011896A KR1019900020321A KR900020321A KR910011896A KR 910011896 A KR910011896 A KR 910011896A KR 1019900020321 A KR1019900020321 A KR 1019900020321A KR 900020321 A KR900020321 A KR 900020321A KR 910011896 A KR910011896 A KR 910011896A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- chloro
- glucosyl group
- epi
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 일반식(Ⅰ) 화합물 또는 그의 약학적으로 허용가능한 염 :상기식에서의 (4-에피-반코스아미닐)-0-글루코실 그룹 또는X는 수소 또는 클로로이며; Y는 수소 또는 클로로이고; R1, R2및 R3는 독립적으로 수소; C1내지 C12알킬; C2내지 C9알카노일; 또는 일반식[여기에서, n은 1 내지 3이고; R4는 수소, 할로, C1내지 C8알킬, C1내지 C8알콕시, 또는 일반식(이때 R5및 R6는 독립적으로 수소 또는 C1내지 C3알킬이다)의 그룹이며; p는 0 내지 2이고; m은 2 또는 3이며; r-은 3-m이다]의 그룹이나, 단, R이 (4-에피-반코스아미닐)-0-글루코실 그룹일때, R1, R2및 R3가 모두 수소는 아니며, R이 수소 또는 글루코실 그룹일때, R1및 R3가 둘다 수소는 아니다.
- 제1항에 있어서, R이 (4-에피-반코스아미닐)-0-글루코실 그룹이고, X 및 Y가 클로로이며, R1및 R3가 수소이고, R2가 n-옥틸인 화합물.
- 제1항에 있어서, R이 (4-에피-반코스아미닐)-0-글루코실 그룹이고, X 및 Y가 클로로이며, R1및 R3가 수소이고, R2가 일반식(여기에서 n은 1이고 R4는 클로로이다)의 그룹인 화합물.
- 적합한 약학적 비히클과 함께 1,2 또는 3항에 청구된 바와 같은 화합물을 활성 성분으로서 포함하는 항세균성 약학제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44917189A | 1989-12-13 | 1989-12-13 | |
US449,171 | 1989-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910011896A true KR910011896A (ko) | 1991-08-07 |
Family
ID=23783157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900020321A KR910011896A (ko) | 1989-12-13 | 1990-12-11 | 신규한 글리코펩티드 유도체 |
Country Status (20)
Country | Link |
---|---|
US (1) | US5591714A (ko) |
EP (1) | EP0435503B1 (ko) |
JP (1) | JP3590638B2 (ko) |
KR (1) | KR910011896A (ko) |
CN (1) | CN1034506C (ko) |
CA (1) | CA2031803C (ko) |
DE (1) | DE69033087T2 (ko) |
ES (1) | ES2131496T3 (ko) |
FI (1) | FI906083A (ko) |
HU (1) | HUT55802A (ko) |
IE (1) | IE904485A1 (ko) |
IL (1) | IL96603A (ko) |
MX (1) | MX23672A (ko) |
NO (1) | NO303692B1 (ko) |
NZ (1) | NZ236393A (ko) |
PH (1) | PH27373A (ko) |
PT (1) | PT96139B (ko) |
RU (2) | RU2041237C1 (ko) |
YU (1) | YU234790A (ko) |
ZA (1) | ZA909847B (ko) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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US5721208A (en) * | 1991-06-29 | 1998-02-24 | Hoechst Aktiengesellschaft | Glycopeptides a process for their preparation and their use |
TW213468B (ko) * | 1991-06-29 | 1993-09-21 | Hoechst Ag | |
US5840684A (en) * | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
MY128335A (en) * | 1994-01-28 | 2007-01-31 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
US5919756A (en) * | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
US5952466A (en) * | 1997-11-12 | 1999-09-14 | Eli Lilly And Company | Reductive alkylation of glycopeptide antibiotics |
US5939382A (en) * | 1996-11-21 | 1999-08-17 | Eli Lilly And Company | Reducing agent for reductive alkylation of glycopeptide antibiotics |
ID18900A (id) * | 1996-11-21 | 1998-05-20 | Lilly Co Eli | Alkilasi menurun dari gliko peptida anti biotik |
US5977063A (en) * | 1997-05-20 | 1999-11-02 | Eli Lilly And Company | Alkylated hexapeptides |
US5952310A (en) * | 1997-05-20 | 1999-09-14 | Eli Lilly And Company | Glycopeptide hexapeptides |
US5919771A (en) * | 1997-05-20 | 1999-07-06 | Eli Lilly And Company | Urea and thiourea derivatives of glycopeptides |
US5972933A (en) * | 1998-01-08 | 1999-10-26 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Method of treating microbial infections |
JP4307723B2 (ja) * | 1998-05-01 | 2009-08-05 | イーライ リリー アンド カンパニー | N1−修飾グリコペプチド |
KR20070040426A (ko) | 1998-06-11 | 2007-04-16 | 파마시아 앤드 업존 캄파니 엘엘씨 | 빠르게 침전하는 약물의 정제 제제 |
SI1140993T1 (en) | 1998-12-23 | 2003-12-31 | Theravance, Inc. | Glycopeptide derivatives and pharmaceutical compositions containing the same |
GB9925127D0 (en) * | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
US20020004502A1 (en) * | 2000-01-05 | 2002-01-10 | Redmond H. Paul | Treatment of inflammatory bowel disease |
NZ520482A (en) | 2000-02-11 | 2004-12-24 | Lilly Co Eli | Selective N-acylation of A82846 glycopeptide analogs that are ueful for treating staphylococcal infection |
AU2001259306A1 (en) * | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin |
DE60135102D1 (de) * | 2000-05-02 | 2008-09-11 | Theravance Inc | Verfahren zur reduktiven alkylierung von glykopeptiden |
US6770621B2 (en) | 2000-05-02 | 2004-08-03 | Theravance, Inc. | Polyacid glycopeptide derivatives |
EP1154663B1 (en) * | 2000-05-09 | 2008-09-24 | Lucent Technologies Inc. | Improved quality of service control in a mobile telecommunications network |
DE60133198T2 (de) * | 2000-06-22 | 2009-03-12 | Theravance, Inc., South San Francisco | Glykopeptidderivate mit carboxysacchariden |
UA75083C2 (uk) * | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
US6872804B2 (en) * | 2000-06-22 | 2005-03-29 | Theravance, Inc. | Glycopeptide disulfide and thioester derivatives |
AU2001259816A1 (en) | 2000-06-22 | 2002-01-02 | Advanced Medecine, Inc. | Polyhydroxy glycopeptide derivatives |
TWI312785B (en) * | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
TWI275594B (en) | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
US20050013854A1 (en) | 2003-04-09 | 2005-01-20 | Mannino Raphael J. | Novel encochleation methods, cochleates and methods of use |
BRPI0516657A (pt) | 2004-11-29 | 2008-09-16 | Univ Nagoya Nat Univ Corp | derivados de monÈmero antibiótico de glicopeptìdeo |
AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
US8652504B2 (en) | 2005-09-22 | 2014-02-18 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
CA2623198C (en) | 2005-09-22 | 2014-08-05 | Medivas, Llc | Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
TW200808818A (en) | 2006-05-26 | 2008-02-16 | Shionogi & Co | Glycopeptide antibiotic derivatives |
WO2009081958A1 (ja) * | 2007-12-26 | 2009-07-02 | Shionogi & Co., Ltd. | グリコペプチド抗生物質配糖化誘導体 |
US8841440B2 (en) | 2008-04-01 | 2014-09-23 | Cornell University | Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof |
CN101928331B (zh) * | 2009-06-26 | 2014-05-28 | 上海来益生物药物研究开发中心有限责任公司 | 一种化合物及其应用 |
WO2012151517A1 (en) | 2011-05-05 | 2012-11-08 | Coordinated Program Development, Llc | Cochleate compositions and methods of making and using same |
CN104418941B (zh) * | 2013-08-19 | 2017-11-07 | 爱斯医药科技(南京)有限公司 | 万古霉素衍生物、制备方法及其应用 |
US20160303184A1 (en) | 2013-09-23 | 2016-10-20 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Vancomycin-sugar conjugates and uses thereof |
AU2015289602B2 (en) * | 2014-07-17 | 2020-06-25 | Abbvie Inc. | High purity oritavancin and method of producing same |
CN108409837B (zh) | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
Family Cites Families (8)
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US4552701A (en) * | 1984-04-16 | 1985-11-12 | Eli Lilly And Company | Glycopeptide antibiotics and process of preparation |
US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
US4643987A (en) * | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
US4639433A (en) * | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
US4946941A (en) * | 1986-01-24 | 1990-08-07 | Shionogi & Co., Ltd. | Novel glycopeptide antibiotics |
EG18377A (en) * | 1986-09-19 | 1993-04-30 | Lilly Co Eli | Process for preparing glycopeptide antibiotics |
GB8701872D0 (en) * | 1987-01-28 | 1987-03-04 | Lepetit Spa | N15-alkyl & n15,n15-dialkyl derivatives |
US5071749A (en) * | 1987-04-16 | 1991-12-10 | Shionogi & Co., Ltd. | Glycopetide antibiotic pa-45052-b |
-
1990
- 1990-12-07 NZ NZ236393A patent/NZ236393A/en unknown
- 1990-12-07 IL IL96603A patent/IL96603A/en not_active IP Right Cessation
- 1990-12-07 ZA ZA909847A patent/ZA909847B/xx unknown
- 1990-12-07 CA CA002031803A patent/CA2031803C/en not_active Expired - Lifetime
- 1990-12-10 MX MX2367290A patent/MX23672A/es unknown
- 1990-12-10 PH PH41697A patent/PH27373A/en unknown
- 1990-12-10 PT PT96139A patent/PT96139B/pt not_active IP Right Cessation
- 1990-12-11 KR KR1019900020321A patent/KR910011896A/ko not_active Application Discontinuation
- 1990-12-11 NO NO905354A patent/NO303692B1/no unknown
- 1990-12-11 DE DE69033087T patent/DE69033087T2/de not_active Expired - Fee Related
- 1990-12-11 JP JP41026690A patent/JP3590638B2/ja not_active Expired - Fee Related
- 1990-12-11 FI FI906083A patent/FI906083A/fi not_active IP Right Cessation
- 1990-12-11 ES ES90313410T patent/ES2131496T3/es not_active Expired - Lifetime
- 1990-12-11 EP EP90313410A patent/EP0435503B1/en not_active Expired - Lifetime
- 1990-12-12 IE IE448590A patent/IE904485A1/en unknown
- 1990-12-12 CN CN90109932A patent/CN1034506C/zh not_active Expired - Fee Related
- 1990-12-12 HU HU908244A patent/HUT55802A/hu unknown
- 1990-12-12 YU YU234790A patent/YU234790A/sh unknown
-
1991
- 1991-12-06 RU SU915010249A patent/RU2041237C1/ru not_active IP Right Cessation
- 1991-12-06 RU SU915010336A patent/RU2053240C1/ru not_active IP Right Cessation
-
1994
- 1994-10-13 US US08/322,972 patent/US5591714A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU6796490A (en) | 1991-06-20 |
DE69033087T2 (de) | 1999-10-14 |
NO905354D0 (no) | 1990-12-11 |
ES2131496T3 (es) | 1999-08-01 |
ZA909847B (en) | 1992-08-26 |
JP3590638B2 (ja) | 2004-11-17 |
PH27373A (en) | 1993-06-21 |
US5591714A (en) | 1997-01-07 |
NO303692B1 (no) | 1998-08-17 |
FI906083A (fi) | 1991-06-14 |
CA2031803A1 (en) | 1991-06-14 |
NO905354L (no) | 1991-06-14 |
DE69033087D1 (de) | 1999-06-10 |
IE904485A1 (en) | 1991-06-19 |
MX23672A (es) | 1993-11-01 |
CA2031803C (en) | 2001-05-29 |
IL96603A0 (en) | 1991-09-16 |
EP0435503A1 (en) | 1991-07-03 |
PT96139B (pt) | 1998-04-30 |
RU2053240C1 (ru) | 1996-01-27 |
YU234790A (sh) | 1992-12-21 |
EP0435503B1 (en) | 1999-05-06 |
CN1052483A (zh) | 1991-06-26 |
PT96139A (pt) | 1991-09-30 |
RU2041237C1 (ru) | 1995-08-09 |
FI906083A0 (fi) | 1990-12-11 |
JPH04108800A (ja) | 1992-04-09 |
IL96603A (en) | 1998-02-08 |
HUT55802A (en) | 1991-06-28 |
AU633165B2 (en) | 1993-01-21 |
CN1034506C (zh) | 1997-04-09 |
NZ236393A (en) | 1992-05-26 |
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