KR910011896A - 신규한 글리코펩티드 유도체 - Google Patents

신규한 글리코펩티드 유도체 Download PDF

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Publication number
KR910011896A
KR910011896A KR1019900020321A KR900020321A KR910011896A KR 910011896 A KR910011896 A KR 910011896A KR 1019900020321 A KR1019900020321 A KR 1019900020321A KR 900020321 A KR900020321 A KR 900020321A KR 910011896 A KR910011896 A KR 910011896A
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KR
South Korea
Prior art keywords
hydrogen
chloro
glucosyl group
epi
compound
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KR1019900020321A
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English (en)
Inventor
나가라잔 라마크리슈난
아폴리나리아 샤벨 아멜리아
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR910011896A publication Critical patent/KR910011896A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

신규한 글리코펩티드 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 일반식(Ⅰ) 화합물 또는 그의 약학적으로 허용가능한 염 :
    상기식에서
    의 (4-에피-반코스아미닐)-0-글루코실 그룹 또는
    X는 수소 또는 클로로이며; Y는 수소 또는 클로로이고; R1, R2및 R3는 독립적으로 수소; C1내지 C12알킬; C2내지 C9알카노일; 또는 일반식
    [여기에서, n은 1 내지 3이고; R4는 수소, 할로, C1내지 C8알킬, C1내지 C8알콕시, 또는 일반식(이때 R5및 R6는 독립적으로 수소 또는 C1내지 C3알킬이다)의 그룹이며; p는 0 내지 2이고; m은 2 또는 3이며; r-은 3-m이다]의 그룹이나, 단, R이 (4-에피-반코스아미닐)-0-글루코실 그룹일때, R1, R2및 R3가 모두 수소는 아니며, R이 수소 또는 글루코실 그룹일때, R1및 R3가 둘다 수소는 아니다.
  2. 제1항에 있어서, R이 (4-에피-반코스아미닐)-0-글루코실 그룹이고, X 및 Y가 클로로이며, R1및 R3가 수소이고, R2가 n-옥틸인 화합물.
  3. 제1항에 있어서, R이 (4-에피-반코스아미닐)-0-글루코실 그룹이고, X 및 Y가 클로로이며, R1및 R3가 수소이고, R2가 일반식(여기에서 n은 1이고 R4는 클로로이다)의 그룹인 화합물.
  4. 적합한 약학적 비히클과 함께 1,2 또는 3항에 청구된 바와 같은 화합물을 활성 성분으로서 포함하는 항세균성 약학제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900020321A 1989-12-13 1990-12-11 신규한 글리코펩티드 유도체 KR910011896A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44917189A 1989-12-13 1989-12-13
US449,171 1989-12-13

Publications (1)

Publication Number Publication Date
KR910011896A true KR910011896A (ko) 1991-08-07

Family

ID=23783157

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900020321A KR910011896A (ko) 1989-12-13 1990-12-11 신규한 글리코펩티드 유도체

Country Status (20)

Country Link
US (1) US5591714A (ko)
EP (1) EP0435503B1 (ko)
JP (1) JP3590638B2 (ko)
KR (1) KR910011896A (ko)
CN (1) CN1034506C (ko)
CA (1) CA2031803C (ko)
DE (1) DE69033087T2 (ko)
ES (1) ES2131496T3 (ko)
FI (1) FI906083A (ko)
HU (1) HUT55802A (ko)
IE (1) IE904485A1 (ko)
IL (1) IL96603A (ko)
MX (1) MX23672A (ko)
NO (1) NO303692B1 (ko)
NZ (1) NZ236393A (ko)
PH (1) PH27373A (ko)
PT (1) PT96139B (ko)
RU (2) RU2041237C1 (ko)
YU (1) YU234790A (ko)
ZA (1) ZA909847B (ko)

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US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
TW213468B (ko) * 1991-06-29 1993-09-21 Hoechst Ag
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
MY128335A (en) * 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
JP4307723B2 (ja) * 1998-05-01 2009-08-05 イーライ リリー アンド カンパニー Ｎ１−修飾グリコペプチド
KR20070040426A (ko) 1998-06-11 2007-04-16 파마시아 앤드 업존 캄파니 엘엘씨 빠르게 침전하는 약물의 정제 제제
SI1140993T1 (en) 1998-12-23 2003-12-31 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20020004502A1 (en) * 2000-01-05 2002-01-10 Redmond H. Paul Treatment of inflammatory bowel disease
NZ520482A (en) 2000-02-11 2004-12-24 Lilly Co Eli Selective N-acylation of A82846 glycopeptide analogs that are ueful for treating staphylococcal infection
AU2001259306A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
DE60135102D1 (de) * 2000-05-02 2008-09-11 Theravance Inc Verfahren zur reduktiven alkylierung von glykopeptiden
US6770621B2 (en) 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
EP1154663B1 (en) * 2000-05-09 2008-09-24 Lucent Technologies Inc. Improved quality of service control in a mobile telecommunications network
DE60133198T2 (de) * 2000-06-22 2009-03-12 Theravance, Inc., South San Francisco Glykopeptidderivate mit carboxysacchariden
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6872804B2 (en) * 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
AU2001259816A1 (en) 2000-06-22 2002-01-02 Advanced Medecine, Inc. Polyhydroxy glycopeptide derivatives
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TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
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BRPI0516657A (pt) 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
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AU2015289602B2 (en) * 2014-07-17 2020-06-25 Abbvie Inc. High purity oritavancin and method of producing same
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

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US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
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Also Published As

Publication number Publication date
AU6796490A (en) 1991-06-20
DE69033087T2 (de) 1999-10-14
NO905354D0 (no) 1990-12-11
ES2131496T3 (es) 1999-08-01
ZA909847B (en) 1992-08-26
JP3590638B2 (ja) 2004-11-17
PH27373A (en) 1993-06-21
US5591714A (en) 1997-01-07
NO303692B1 (no) 1998-08-17
FI906083A (fi) 1991-06-14
CA2031803A1 (en) 1991-06-14
NO905354L (no) 1991-06-14
DE69033087D1 (de) 1999-06-10
IE904485A1 (en) 1991-06-19
MX23672A (es) 1993-11-01
CA2031803C (en) 2001-05-29
IL96603A0 (en) 1991-09-16
EP0435503A1 (en) 1991-07-03
PT96139B (pt) 1998-04-30
RU2053240C1 (ru) 1996-01-27
YU234790A (sh) 1992-12-21
EP0435503B1 (en) 1999-05-06
CN1052483A (zh) 1991-06-26
PT96139A (pt) 1991-09-30
RU2041237C1 (ru) 1995-08-09
FI906083A0 (fi) 1990-12-11
JPH04108800A (ja) 1992-04-09
IL96603A (en) 1998-02-08
HUT55802A (en) 1991-06-28
AU633165B2 (en) 1993-01-21
CN1034506C (zh) 1997-04-09
NZ236393A (en) 1992-05-26

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