ES2131496T3 - Mejoras relativas a derivados glicopeptidicos. - Google Patents

Mejoras relativas a derivados glicopeptidicos.

Info

Publication number
ES2131496T3
ES2131496T3 ES90313410T ES90313410T ES2131496T3 ES 2131496 T3 ES2131496 T3 ES 2131496T3 ES 90313410 T ES90313410 T ES 90313410T ES 90313410 T ES90313410 T ES 90313410T ES 2131496 T3 ES2131496 T3 ES 2131496T3
Authority
ES
Spain
Prior art keywords
derivatives
glycopeptidic
improvements related
new
grama
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90313410T
Other languages
English (en)
Inventor
Ramakrishnan Nagarajan
Amelia Apolinaria Schabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2131496T3 publication Critical patent/ES2131496T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE SUMINISTRAN NUEVOS DERIVADOS N-ALQUILO Y N-ACILO DE A82846A, A82846B, A82846C Y PA-42867-A. LOS NUEVOS DERIVADOS GLICOPEPTIDOS SON UTILES PARA TRATAMIENTO DE INFECCIONES BACTERIANAS SUSCEPTIBLES, ESPECIALMENTE INFECCIONES DEBIDAS A MICROORGANISMOS GRAMA-POSITIVOS.
ES90313410T 1989-12-13 1990-12-11 Mejoras relativas a derivados glicopeptidicos. Expired - Lifetime ES2131496T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44917189A 1989-12-13 1989-12-13

Publications (1)

Publication Number Publication Date
ES2131496T3 true ES2131496T3 (es) 1999-08-01

Family

ID=23783157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90313410T Expired - Lifetime ES2131496T3 (es) 1989-12-13 1990-12-11 Mejoras relativas a derivados glicopeptidicos.

Country Status (20)

Country Link
US (1) US5591714A (es)
EP (1) EP0435503B1 (es)
JP (1) JP3590638B2 (es)
KR (1) KR910011896A (es)
CN (1) CN1034506C (es)
CA (1) CA2031803C (es)
DE (1) DE69033087T2 (es)
ES (1) ES2131496T3 (es)
FI (1) FI906083A (es)
HU (1) HUT55802A (es)
IE (1) IE904485A1 (es)
IL (1) IL96603A (es)
MX (1) MX23672A (es)
NO (1) NO303692B1 (es)
NZ (1) NZ236393A (es)
PH (1) PH27373A (es)
PT (1) PT96139B (es)
RU (2) RU2041237C1 (es)
YU (1) YU234790A (es)
ZA (1) ZA909847B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW213468B (es) * 1991-06-29 1993-09-21 Hoechst Ag
US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
MY128335A (en) * 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
DE69936052T2 (de) 1998-05-01 2008-01-17 Eli Lilly And Co., Indianapolis N1 modifizierte glycopeptide
JP4827296B2 (ja) 1998-06-11 2011-11-30 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー デラビルジン錠製剤
WO2000039156A1 (en) 1998-12-23 2000-07-06 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20020004502A1 (en) * 2000-01-05 2002-01-10 Redmond H. Paul Treatment of inflammatory bowel disease
CA2399640A1 (en) * 2000-02-11 2001-08-16 Eli Lilly And Company Selective n-acylation of a82846 glycopeptide analogs
AU2001259298A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
AU2001257464A1 (en) * 2000-05-02 2001-11-12 Theravance, Inc. Reductive alkylation process on glycopeptides
EP1278549B1 (en) * 2000-05-02 2008-12-10 Theravance, Inc. Composition containing a cyclodextrin and a glycopeptide antibiotic
DE60040329D1 (de) * 2000-05-09 2008-11-06 Lucent Technologies Inc Verbesserte Steurung der Dienstequalität in einem mobilen Telekommunikationsnetz
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
US6828299B2 (en) 2000-06-22 2004-12-07 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) * 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) * 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
BRPI0516657A (pt) * 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp derivados de monÈmero antibiótico de glicopeptìdeo
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8445007B2 (en) 2005-09-22 2013-05-21 Medivas, Llc Bis-(α-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
US8481696B2 (en) 2007-12-26 2013-07-09 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivatives
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
CN101928331B (zh) * 2009-06-26 2014-05-28 上海来益生物药物研究开发中心有限责任公司 一种化合物及其应用
JP6347743B2 (ja) 2011-05-05 2018-06-27 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド コクリエート組成物およびその製造および使用方法
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
AU2014322817A1 (en) 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
CN107206050A (zh) * 2014-07-17 2017-09-26 医药公司 高纯度奥利万星及其生产方法
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b

Also Published As

Publication number Publication date
IL96603A0 (en) 1991-09-16
PT96139B (pt) 1998-04-30
CN1034506C (zh) 1997-04-09
DE69033087D1 (de) 1999-06-10
PH27373A (en) 1993-06-21
JP3590638B2 (ja) 2004-11-17
EP0435503B1 (en) 1999-05-06
CA2031803C (en) 2001-05-29
ZA909847B (en) 1992-08-26
FI906083A0 (fi) 1990-12-11
NO905354L (no) 1991-06-14
NO303692B1 (no) 1998-08-17
EP0435503A1 (en) 1991-07-03
FI906083A (fi) 1991-06-14
RU2041237C1 (ru) 1995-08-09
RU2053240C1 (ru) 1996-01-27
YU234790A (sh) 1992-12-21
CA2031803A1 (en) 1991-06-14
IL96603A (en) 1998-02-08
AU6796490A (en) 1991-06-20
KR910011896A (ko) 1991-08-07
JPH04108800A (ja) 1992-04-09
US5591714A (en) 1997-01-07
HUT55802A (en) 1991-06-28
PT96139A (pt) 1991-09-30
NZ236393A (en) 1992-05-26
IE904485A1 (en) 1991-06-19
MX23672A (es) 1993-11-01
AU633165B2 (en) 1993-01-21
CN1052483A (zh) 1991-06-26
DE69033087T2 (de) 1999-10-14
NO905354D0 (no) 1990-12-11

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