KR890012967A - 피페리딘 유도체 - Google Patents

피페리딘 유도체 Download PDF

Info

Publication number
KR890012967A
KR890012967A KR1019890002059A KR890002059A KR890012967A KR 890012967 A KR890012967 A KR 890012967A KR 1019890002059 A KR1019890002059 A KR 1019890002059A KR 890002059 A KR890002059 A KR 890002059A KR 890012967 A KR890012967 A KR 890012967A
Authority
KR
South Korea
Prior art keywords
group
alkyl
dichlorophenyl
acetyl
compound
Prior art date
Application number
KR1019890002059A
Other languages
English (en)
Inventor
프랭크 헤이스 노먼
아이언 키터 스콥스 데이비드
브라이언 맥켈로이 앤드류
게일 헤이스 앤
앨빈 미어홀즈 클리브
Original Assignee
추후보충
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후보충, 글락소 그룹 리미티드 filed Critical 추후보충
Publication of KR890012967A publication Critical patent/KR890012967A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

피페리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식Ⅰ의 화합물 및 생리적으로 허용되는 그들의 염
    식중, R1은 히드록시, C1-6알킬, C1-6히드록시알킬, C1-6카르복시알킬, 페닐, 옥소, 아미노, 카르복시, 아미도, -NR4CO5, 치환 또는 비(非)치환 메틸리덴기를 나타내거나, 또는 R1은 이 기가 결합된 탄소원자와 함께 1개 이상의 헤테로 원자를 갖는 5원 또는 6원 고리를 형성하며, R2및 R3은 서로 동일하거나 또는 상이한 것으로, C1-6알킬 또는 C3-6알케닐기를 나타내거나, 또는 -NR3R3는 히드록시, 옥소, 치환 또는 비치환 메틸리덴, -COR6또는 =NOR8기에 의해 치환 또는 비치환되는, 임의로 1단위의 불포화를 가질 수 있는 5원(질소원자와 인접한 산소원자를 임의로 가짐) 또는 6원 고리를 형성하며, R4및 R5는 모두 C1-6알킬기를 나타내며, R6는 C1-6알킬, -OR7또는 NHR7기를 나타내며, R7은 수소, C1-6알킬, 아릴 또는 아르(C1-6)알킬기를 나타내며, R8은 C1-6알킬기를 나타내며, X는 직접 결합, -CH2- 또는 -CH2O-를 나타내며, Ar은 치환 페닐 부위를 나타낸다.
  2. 제1항에 있어서, 치환체 R1이 피페리딘 고리의 3,4 또는 6위치에 결합되는 화합물.
  3. 제1 또는 2항에 있어서, R1이 C1-6알킬 또는 옥소기이거나 또는 R1이 이 기가 결합된 탄소원자와 함께 1개 이상의 헤테로원자를 갖는 5원 또는 6원 고리를 형성하는 화합물.
  4. 제1 또는 3항에 있어서, -NR2R3이 테트라히드로피리딘 또는 피롤리딘 고리를 나타내는 화합물.
  5. 제4항에 있어서, -NR2R3이 피롤리딘 고리를 나타내는 화합물.
  6. 제4항에 있어서, R1이 -CH3이고, 치환체 R1이 3 또는 6-위치인 화합물.
  7. 제4항에 있어서, R1이 =0, 1,3-디옥살란, 1,3-디티올란 또는 티아졸리딘이고, 치환체 R1이 4-위치인 화합물.
  8. 제6 또는 7항에 있어서, X가 -CH2-이고, Ar이 할로치환된 페닐기인 화합물.
  9. 1-[(3,4-디클로로페닐)아세틸]-2-(1-피롤리디닐메틸)-4-피페리디논, 8-[(3,4-디클로로페닐)아세틸]-7-[(1,2,3,6-테트라히드로 피리딘-1-일)메틸]=1,4-디옥사-8-아자스피로[4,5]데칸, 1-[(3,4-디클로로페닐)아세틸]-3-메틸-2-(1-피롤리디닐메틸)피페리딘, 8-[(3,4-디클로로페닐)아세틸]-7-(1-피롤리디닐메틸)-1-티아-4,8-디아조스피로[4.5]데칸, 8-[(3,4-디클로로페닐)아세틸]-7-(1-피롤리디닐메틸)-1,4-디티아-8-아자스피로[4.5]데칸, 시스-1-[(3,4-디클로로페닐)아세틸]-2-메틸-6-(11-피롤리디닐메틸)피페리딘 및 생리적으로 허용되는 상기 화합물들의 염.
  10. 8-[(3,4-디클로로페닐)아세틸]-7-(1-피롤리디닐메틸)-1,4-디옥사-8-아자[4.5]스피로데칸 및 생이적으로 허용되는 그의 염.
  11. 제약상 허용되는 담체와 함께 제1항에서 정의된 일반식(Ⅰ)의 화합물 또는 그의 생리적으로 허용되는 염의 유효량으로 됨을 특징으로 하는 제약 조성물.
  12. 통증 또는 뇌빈혈을 앓는 사람을 치료하는 데 있어서, 제1항에서 정의된 일반식(Ⅰ)의 화합물 또는 그의 생리적으로 허용되는 염을 유효량으로 투여하는 것을 됨을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890002059A 1988-02-23 1989-02-22 피페리딘 유도체 KR890012967A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8804104 1988-02-23
GB888804104A GB8804104D0 (en) 1988-02-23 1988-02-23 Chemical compounds

Publications (1)

Publication Number Publication Date
KR890012967A true KR890012967A (ko) 1989-09-20

Family

ID=10632154

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890002059A KR890012967A (ko) 1988-02-23 1989-02-22 피페리딘 유도체

Country Status (10)

Country Link
EP (1) EP0330461A3 (ko)
JP (1) JPH01308250A (ko)
KR (1) KR890012967A (ko)
AU (1) AU625968B2 (ko)
DK (1) DK84689A (ko)
FI (1) FI890866A (ko)
GB (1) GB8804104D0 (ko)
NZ (1) NZ228112A (ko)
PT (1) PT89779B (ko)
ZA (1) ZA891415B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68924751T2 (de) * 1988-09-26 1996-04-11 Smithkline Beecham Farma Azacyclische Verbindungen, verwendbar als Arzneimittel.
PT94070A (pt) * 1989-05-18 1991-01-08 Glaxo Group Ltd Processo para a preparacao de derivados de piperazina
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
JPH05501551A (ja) * 1989-11-24 1993-03-25 スミスクライン　ビーチャム　ファルマシューティッチ　エッセ　ピ　ア アザ環式誘導体
EP0447704A1 (en) * 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
AU7681491A (en) * 1990-04-28 1991-11-27 Dr. Lo Zambeletti S.P.A. Novel 1-(2h-1-oxo-3,4-dihydronaphtyl-6)-acetyl-piperidines, process for their preparation and therapeutic use
GB9011656D0 (en) * 1990-05-24 1990-07-11 Zambeletti Spa L Novel compounds
GB9104656D0 (en) * 1991-03-05 1991-04-17 Zambeletti Spa L Pharmaceuticals
WO1992018115A1 (en) * 1991-04-18 1992-10-29 Dr Lo Zambeletti S.P.A. Use of heterocyclic compounds for the treatment of inflammatory pain
AU1760992A (en) * 1991-05-21 1992-12-30 Dr. Lo Zambeletti S.P.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
ES2053394B1 (es) * 1992-11-16 1995-02-16 S A L V A T Lab Sa "3-bromo-4-oxo-1-piperidincarboxilato de etilo, procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion"
WO1995011895A1 (en) * 1993-10-26 1995-05-04 Ciba-Geigy Ag N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists
ATE212981T1 (de) * 1994-09-30 2002-02-15 Novartis Erfind Verwalt Gmbh 1-acyl-4-aliphatische aminopiperidin verbindungen
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6750216B2 (en) 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
USRE38133E1 (en) * 1996-03-08 2003-06-03 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6057323A (en) * 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound
WO2018152329A1 (en) 2017-02-15 2018-08-23 Ohio State Innovation Foundation Heteroaromatic electrophiles and methods of using thereof
WO2019113419A1 (en) * 2017-12-08 2019-06-13 The Rockefeller University Pyrano[3,4-b]pyrazine kappa opioid receptor ligands for treating addiction, pruritus, pain, and inflammation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2684965A (en) * 1950-08-10 1954-07-27 Abbott Lab Aminoalkylpiperidines
DE3670080D1 (de) * 1985-12-23 1990-05-10 Zambeletti Spa L Azacyclische verbindungen, verfahren zur ihrer herstellung und ihre verwendung als pharmazeutika.
ES2039242T3 (es) * 1986-09-02 1993-09-16 Dr. Lo. Zambeletti S.P.A. Un procedimiento para la preparacion de nuevos derivados de piperidina.
KR890005052A (ko) * 1986-12-22 1989-05-11 기오르지오 스키니나 신규 피페리딘 유도체

Also Published As

Publication number Publication date
ZA891415B (en) 1990-02-28
JPH01308250A (ja) 1989-12-12
PT89779A (pt) 1989-10-04
NZ228112A (en) 1991-12-23
AU625968B2 (en) 1992-07-23
FI890866A (fi) 1989-08-24
PT89779B (pt) 1994-04-29
DK84689A (da) 1989-08-24
EP0330461A3 (en) 1990-10-17
DK84689D0 (da) 1989-02-23
FI890866A0 (fi) 1989-02-23
GB8804104D0 (en) 1988-03-23
AU3029589A (en) 1989-08-24
EP0330461A2 (en) 1989-08-30

Similar Documents

Publication Publication Date Title
KR890012967A (ko) 피페리딘 유도체
KR900018073A (ko) 피페라진 화합물
LU90856I2 (fr) Uprima - apomorphine hydrochloride et ses d-riv-s pharmaceutiquement acceptables
KR900006341A (ko) 이형고리 화합물
ZA906709B (en) Thiazolidinedione derivatives
DE69230163T2 (de) Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
KR890012970A (ko) 테트라히드로 이소퀴놀린 유도체
DE69811329T2 (de) Imidazolidin-4-on Derivate verwendbar als Antikrebsmittel
EP0328000A3 (de) Indolocarbazol-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
IL137266A0 (en) Heterocyclic chemokine receptor antagonists and pharmaceutical compositions containing the same
KR900006331A (ko) 항미생물성 퀴놀로닐 락탐
KR900001715A (ko) Bu-3608 유도체
KR880011154A (ko) 벤즈옥사진 유도체 및 이의 제조방법
KR930006024A (ko) 이미다조 인돌리진 유도체 및 그의 제조방법
FR2671349B1 (fr) Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE69625795T2 (de) Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven Eigenschaften, Verfahren zu deren Herstellung und pharmazeutischen Zusammenstellungen, die sie enthalten
KR900001654A (ko) 글리세린 유도체 및 그의 약물학적 용도
IL83216A (en) 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
DE68922053T2 (de) Pyridoindolderivate und Verfahren zu ihrer Herstellung.
ATE143658T1 (de) Pyrrolidin-derivate
NZ229300A (en) Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
KR880013896A (ko) 벤조푸로[3,2-c]퀴놀린 화합물
ES2032838T3 (es) Un procedimiento para preparar derivados tetrahidropirido (1,2-a)indol.
DE3671016D1 (de) Thiazolidinderivate und verfahren zu ihrer herstellung.
ATE29133T1 (de) Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid