DE69230163T2 - Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten - Google Patents
Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthaltenInfo
- Publication number
- DE69230163T2 DE69230163T2 DE69230163T DE69230163T DE69230163T2 DE 69230163 T2 DE69230163 T2 DE 69230163T2 DE 69230163 T DE69230163 T DE 69230163T DE 69230163 T DE69230163 T DE 69230163T DE 69230163 T2 DE69230163 T2 DE 69230163T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- acyl
- cyano
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919117733A GB9117733D0 (en) | 1991-08-16 | 1991-08-16 | New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
GB929201057A GB9201057D0 (en) | 1992-01-17 | 1992-01-17 | New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230163D1 DE69230163D1 (de) | 1999-11-25 |
DE69230163T2 true DE69230163T2 (de) | 2000-03-23 |
Family
ID=26299417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69230163T Expired - Fee Related DE69230163T2 (de) | 1991-08-16 | 1992-08-12 | Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
Country Status (16)
Country | Link |
---|---|
US (1) | US5296495A (de) |
EP (1) | EP0528337B1 (de) |
JP (1) | JP2600644B2 (de) |
KR (1) | KR930004304A (de) |
CN (1) | CN1033088C (de) |
AT (1) | ATE185807T1 (de) |
AU (1) | AU665007B2 (de) |
CA (1) | CA2076192A1 (de) |
DE (1) | DE69230163T2 (de) |
DK (1) | DK0528337T3 (de) |
ES (1) | ES2137169T3 (de) |
GR (1) | GR3032425T3 (de) |
HU (2) | HUT64336A (de) |
MX (1) | MX9204746A (de) |
SG (1) | SG45259A1 (de) |
TW (1) | TW224464B (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100329887B1 (ko) * | 1992-11-02 | 2002-11-02 | 시오노기세이야쿠가부시키가이샤 | (e)-알콕시이미노-및하이드록시이미노-아세트아미드화합물의제조방법 및 그의 제조용중간체 |
CA2102078A1 (en) * | 1992-11-02 | 1994-05-03 | Akira Takase | A process for producing (e)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor |
DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
CN1209809A (zh) * | 1996-01-22 | 1999-03-03 | 藤泽药品工业株式会社 | 新化合物 |
US6436966B1 (en) * | 1997-10-27 | 2002-08-20 | Takeda Chemical Ind., Ltd. | Adenosine A3 receptor antagonists |
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
CA2469228A1 (en) | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
EP1424101A3 (de) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Verwendung eines Leukotrien- C4/ D4 -rezeptorantagonisten zur Herstellung eines Medikamentes zur Behandlung oder Vorbeugung von Gehirnentzündung und -sepsis |
US7148248B2 (en) | 2002-11-29 | 2006-12-12 | Masako Nozaki | Method of treating or inhibiting the development of brain inflammation and sepsis |
MXPA05010945A (es) * | 2003-04-09 | 2005-11-25 | Japan Tobacco Inc | Compuesto pentaciclico heteroaromatico y uso medicinal del mismo. |
EP1627873A4 (de) | 2003-05-29 | 2007-12-05 | New Ind Res Organization | Benzofuranverbindung und medizinische zusammensetzung, die diese enthält |
JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
US7915443B2 (en) * | 2006-11-16 | 2011-03-29 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
EP1765333A4 (de) | 2004-07-14 | 2008-06-18 | Inflammation Res Ct Company Lt | Verfahren zur hemmung von tumormetastasierung |
CA2575932A1 (en) * | 2004-08-04 | 2006-02-16 | Schering Corporation | Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases |
EP1817034A1 (de) | 2004-10-25 | 2007-08-15 | Schering Corporation | M1- und/oder m3-rezeptorantagonisten in kombination mit anderen wirkstoffen zur behandlung von atemwegserkrankungen |
WO2006046683A1 (en) * | 2004-10-25 | 2006-05-04 | Astellas Pharma Inc. | Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists |
WO2006054793A1 (ja) * | 2004-11-19 | 2006-05-26 | The New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
KR20090026217A (ko) * | 2006-07-11 | 2009-03-11 | 쉐링 코포레이션 | 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염 |
EP2443134A2 (de) | 2009-06-16 | 2012-04-25 | Schering Corporation | Neue [3,2-c]heteroarylsteroide als glucocorticoidrezeptoragonisten, zusammensetzungen und verwendung |
EP2723718A1 (de) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8-antagonisten und ihre verwendung bei behandlungen |
PE20140868A1 (es) | 2011-06-24 | 2014-07-18 | Amgen Inc | Antagonistas trpm8 y su uso en tratamientos |
PT2797416T (pt) * | 2011-12-28 | 2017-10-23 | Global Blood Therapeutics Inc | Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos |
ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
MY180206A (en) | 2013-03-15 | 2020-11-25 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
DK3102208T3 (da) | 2014-02-07 | 2021-03-08 | Global Blood Therapeutics Inc | Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd |
US10479802B2 (en) * | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
EP3554494A4 (de) | 2016-12-19 | 2021-02-17 | Cellixbio Private Limited | Zusammensetzungen und verfahren zur behandlung von entzündungen |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62142168A (ja) * | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
US4908357A (en) * | 1986-04-30 | 1990-03-13 | Fmc Corporation | Photoactive azole pesticides |
US5001140A (en) * | 1989-04-17 | 1991-03-19 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
JPH02169584A (ja) * | 1988-12-22 | 1990-06-29 | Mitsubishi Kasei Corp | ビニルチアゾール誘導体およびそれを有効成分とする薬剤 |
US5032588A (en) * | 1989-12-08 | 1991-07-16 | Abbott Laboratories | Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
DE3941438A1 (de) * | 1989-12-15 | 1991-06-20 | Hoechst Ag | Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
-
1992
- 1992-08-06 JP JP4210308A patent/JP2600644B2/ja not_active Expired - Fee Related
- 1992-08-12 ES ES92113705T patent/ES2137169T3/es not_active Expired - Lifetime
- 1992-08-12 SG SG1996002173A patent/SG45259A1/en unknown
- 1992-08-12 EP EP92113705A patent/EP0528337B1/de not_active Expired - Lifetime
- 1992-08-12 DK DK92113705T patent/DK0528337T3/da active
- 1992-08-12 DE DE69230163T patent/DE69230163T2/de not_active Expired - Fee Related
- 1992-08-12 US US07/929,751 patent/US5296495A/en not_active Expired - Fee Related
- 1992-08-12 AT AT92113705T patent/ATE185807T1/de not_active IP Right Cessation
- 1992-08-13 AU AU21029/92A patent/AU665007B2/en not_active Ceased
- 1992-08-14 KR KR1019920014712A patent/KR930004304A/ko not_active Application Discontinuation
- 1992-08-14 CA CA002076192A patent/CA2076192A1/en not_active Abandoned
- 1992-08-14 HU HU9202656A patent/HUT64336A/hu unknown
- 1992-08-14 TW TW081106455A patent/TW224464B/zh active
- 1992-08-15 CN CN92110877A patent/CN1033088C/zh not_active Expired - Fee Related
- 1992-08-17 MX MX9204746A patent/MX9204746A/es not_active IP Right Cessation
-
1995
- 1995-06-22 HU HU95P/P00346P patent/HU211630A9/hu unknown
-
2000
- 2000-01-19 GR GR20000400122T patent/GR3032425T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1033088C (zh) | 1996-10-23 |
HUT64336A (en) | 1993-12-28 |
MX9204746A (es) | 1994-04-29 |
GR3032425T3 (en) | 2000-05-31 |
SG45259A1 (en) | 1998-01-16 |
HU9202656D0 (en) | 1992-10-28 |
CN1070910A (zh) | 1993-04-14 |
CA2076192A1 (en) | 1993-02-17 |
EP0528337A1 (de) | 1993-02-24 |
ATE185807T1 (de) | 1999-11-15 |
ES2137169T3 (es) | 1999-12-16 |
TW224464B (de) | 1994-06-01 |
JPH05202040A (ja) | 1993-08-10 |
HU211630A9 (en) | 1995-12-28 |
US5296495A (en) | 1994-03-22 |
EP0528337B1 (de) | 1999-10-20 |
JP2600644B2 (ja) | 1997-04-16 |
KR930004304A (ko) | 1993-03-22 |
AU2102992A (en) | 1993-02-18 |
AU665007B2 (en) | 1995-12-14 |
DE69230163D1 (de) | 1999-11-25 |
DK0528337T3 (da) | 2000-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |