KR880001282A - 옥사자포스포린 용액 및 이의 제조방법 - Google Patents

옥사자포스포린 용액 및 이의 제조방법 Download PDF

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Publication number
KR880001282A
KR880001282A KR1019870007481A KR870007481A KR880001282A KR 880001282 A KR880001282 A KR 880001282A KR 1019870007481 A KR1019870007481 A KR 1019870007481A KR 870007481 A KR870007481 A KR 870007481A KR 880001282 A KR880001282 A KR 880001282A
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KR
South Korea
Prior art keywords
oxazaphosphorin
solution
oxazaphosphorine
chloroethyl
preparation
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KR1019870007481A
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English (en)
Inventor
자우어비어 디터
몰게 클라우스
바이게르트 베르너
이삭 오토
Original Assignee
아스타-베르케 에이지
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Publication date
Application filed by 아스타-베르케 에이지 filed Critical 아스타-베르케 에이지
Publication of KR880001282A publication Critical patent/KR880001282A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Paper (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

내용 없음

Description

옥사자포스포린 용액 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 옥사자포스포린 농도가 10 내지 70%(W/V)인, 80 내지 100%(V/V)에탄올 중의 일반식(Ⅰ)의 옥사자포스포린의 용액.
    상기식에서, R1, R2및 R3는 동일하거나 상이하며 수소, 메틸, 에틸, 2-클로로에틸 또는 2-메탄설포닐옥시에틸을 나타내고 이들 라디칼중 적어도 2개는 2-클로로에틸 및/또는 2-메탄설포닐옥시에틸이다.
  2. 용매 100㎖당 일반식(Ⅰ)의 옥사자포스포린 15 내지 150g을 사용하여 15 내지 40℃ 사이의 온도에서 임의로 용매를 교반(stirring 또는 agitation)시키면서 80 내지 100%(V/V) 수성에탄올 중에 용해시킴을 특징으로 하는 옥사자포스포린 농도가 10 내지 70%(W/V)인, 80 내지 100%(V/V) 에탄올 중의 일반식(Ⅰ)의 옥사자포스포린의 용액을 제조하는 방법.
    상기식에서, R1, R2및 R3는 동일하거나 상이하며 수소, 메틸, 에틸, 2-클로로에틸 또는 2-메탄설포닐옥시에틸을 나타낸다.
  3. 제1항에 있어서, 옥사자포스포린이 사이클로 포스파미드 및/또는 이포스파미드인 용액.
  4. 제2항에 있어서, 옥사자포스포린이 사이클로 포스파미드 및/또는 이포스파미드임을 특징으로 하여 언급한 용액을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870007481A 1986-07-11 1987-07-11 옥사자포스포린 용액 및 이의 제조방법 KR880001282A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3623369.2 1986-07-11
DE3623369 1986-07-11

Publications (1)

Publication Number Publication Date
KR880001282A true KR880001282A (ko) 1988-04-22

Family

ID=6304930

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870007481A KR880001282A (ko) 1986-07-11 1987-07-11 옥사자포스포린 용액 및 이의 제조방법

Country Status (16)

Country Link
US (1) US4952575A (ko)
EP (1) EP0254902B1 (ko)
JP (1) JPS6323888A (ko)
KR (1) KR880001282A (ko)
AT (1) ATE66609T1 (ko)
AU (1) AU598282B2 (ko)
CA (1) CA1289886C (ko)
DE (2) DE3772482D1 (ko)
DK (1) DK168322B1 (ko)
ES (1) ES2038623T3 (ko)
FI (1) FI86690C (ko)
GR (1) GR3002618T3 (ko)
IE (1) IE59897B1 (ko)
IL (1) IL83141A (ko)
PT (1) PT85293B (ko)
ZA (1) ZA875059B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
AU1555099A (en) * 1997-10-13 1999-05-03 Stada Arzneimittel A.G. Liquid presentations of oxazaphosphorine-containing pharmaceutical products
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
AUPQ849900A0 (en) * 2000-06-30 2000-07-27 Dbl Australia Pty Ltd. Injectable composition
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
JP2006508917A (ja) * 2002-09-05 2006-03-16 ブハラット セルムズ アンド ヴァクシンズ リミテッド メスナを有する、オキサザホスホリンの液体安定性組成物
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
US20080262084A1 (en) * 2004-09-13 2008-10-23 Gautam Vinod Daftary Stable Emulsion Compositions for Intravenous Administration Having Preservatie Efficacy
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
AU2015256331B2 (en) * 2014-05-09 2020-03-12 AuroMedics Pharma LLC Formulations of Cyclophosphamide liquid concentrate
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
WO2016132270A1 (en) * 2015-02-16 2016-08-25 Leiutis Pharmaceuticals Pvt Ltd Stable ready to use cyclophosphamide liquid formulations
EP3737676B1 (en) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
WO2022038072A1 (en) * 2020-08-17 2022-02-24 Sandoz Ag Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530147A1 (de) * 1985-08-23 1987-02-26 Bayer Ag Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

Also Published As

Publication number Publication date
ATE66609T1 (de) 1991-09-15
DE3722043A1 (de) 1988-01-14
JPS6323888A (ja) 1988-02-01
AU7554987A (en) 1988-01-14
IL83141A0 (en) 1987-12-31
IL83141A (en) 1992-11-15
IE871867L (en) 1988-01-11
EP0254902A2 (de) 1988-02-03
DK359387D0 (da) 1987-07-10
ES2038623T3 (es) 1993-08-01
PT85293B (pt) 1990-03-30
DK168322B1 (da) 1994-03-14
FI86690C (fi) 1992-10-12
AU598282B2 (en) 1990-06-21
EP0254902B1 (de) 1991-08-28
ZA875059B (en) 1988-02-24
GR3002618T3 (en) 1993-01-25
JPH0543711B2 (ko) 1993-07-02
US4952575A (en) 1990-08-28
DK359387A (da) 1988-01-12
EP0254902A3 (en) 1988-08-03
CA1289886C (en) 1991-10-01
FI86690B (fi) 1992-06-30
DE3772482D1 (de) 1991-10-02
PT85293A (de) 1987-08-01
FI873064A (fi) 1988-01-12
FI873064A0 (fi) 1987-07-10
IE59897B1 (en) 1994-04-20

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