KR860003256A - 아데노신의 n^6-치환된 데옥시리보스 유사체의 제조방법 - Google Patents

아데노신의 n^6-치환된 데옥시리보스 유사체의 제조방법 Download PDF

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Publication number
KR860003256A
KR860003256A KR1019850007937A KR850007937A KR860003256A KR 860003256 A KR860003256 A KR 860003256A KR 1019850007937 A KR1019850007937 A KR 1019850007937A KR 850007937 A KR850007937 A KR 850007937A KR 860003256 A KR860003256 A KR 860003256A
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KR
South Korea
Prior art keywords
adenosine
preparing
substituted deoxyribose
deoxyribose analogs
analogs
Prior art date
Application number
KR1019850007937A
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English (en)
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KR910002226B1 (ko
Inventor
떠블유. 해밀톤 해리어트
Original Assignee
에드워드 에프. 엘스라저
워너-램버트 컴패니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에드워드 에프. 엘스라저, 워너-램버트 컴패니 filed Critical 에드워드 에프. 엘스라저
Publication of KR860003256A publication Critical patent/KR860003256A/ko
Application granted granted Critical
Publication of KR910002226B1 publication Critical patent/KR910002226B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

아데노이신의 N6-치환된 데옥시리보스 유사체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식 (2)의 N-6-치환푸린을 상승된 온도에서, 약 1-12시간동안 다음 일반식 (3)의 화합물과 반응시켜 다음 일반식(1)의 화합물을 제조하는 방법.
  4. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007937A 1984-10-26 1985-10-26 아데노이신의 n6-치환된 데옥시리보스 동족체 및 그 제조방법 KR910002226B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US66523384A 1984-10-26 1984-10-26
US66521784A 1984-10-26 1984-10-26
US66523284A 1984-10-26 1984-10-26
US665,232 1984-10-26
US665,217 1984-10-26
US772,315 1985-06-09
US77231585A 1985-09-06 1985-09-06
US665,233 1991-03-06

Publications (2)

Publication Number Publication Date
KR860003256A true KR860003256A (ko) 1986-05-21
KR910002226B1 KR910002226B1 (ko) 1991-04-08

Family

ID=27505316

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007937A KR910002226B1 (ko) 1984-10-26 1985-10-26 아데노이신의 n6-치환된 데옥시리보스 동족체 및 그 제조방법

Country Status (13)

Country Link
EP (1) EP0181129B1 (ko)
KR (1) KR910002226B1 (ko)
CN (1) CN1013448B (ko)
AU (1) AU575438B2 (ko)
CA (1) CA1260931A (ko)
DE (1) DE3568582D1 (ko)
DK (1) DK488485A (ko)
ES (1) ES8701774A1 (ko)
FI (1) FI81587C (ko)
GR (1) GR852583B (ko)
NO (1) NO165495C (ko)
NZ (1) NZ213971A (ko)
PT (1) PT81373B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206497B1 (en) * 1985-05-15 1994-07-20 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
WO1988003147A1 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
ATE147074T1 (de) * 1990-09-25 1997-01-15 Rhone Poulenc Rorer Int Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen
US5705491A (en) * 1992-10-27 1998-01-06 Nippon Zoki Pharmaceutical Co., Ltd. Adenosine deaminase inhibitor
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
ES2159760T3 (es) * 1995-11-14 2001-10-16 Pharmacia & Upjohn Spa Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina.
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
SK19542000A3 (sk) 1998-06-23 2001-09-11 Glaxo Group Limited 2-(purin-9-yl)-tetrahydrofurn-3,4-diolov derivty, spsob ich vroby, farmaceutick prostriedok s ich obsahom, ich pouitie a medziprodukty
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
US7157440B2 (en) 2001-07-13 2007-01-02 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
EP1375508A1 (en) * 2002-06-27 2004-01-02 Aventis Pharma Deutschland GmbH N6-substituted adenosine analogues and their use as pharmaceutical agents
US7265111B2 (en) 2002-06-27 2007-09-04 Sanofi-Aventis Deutschland Gmbh Adenosine analogues and their use as pharmaceutical agents
CA2515068A1 (en) 2003-02-03 2004-08-19 Cv Therapeutics Inc. Partial and full agonists of a1 adenosine receptors
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545645A1 (de) * 1965-12-06 1969-08-21 Boehringer Mannheim Gmbh Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten
DE1670077C3 (de) * 1966-05-07 1975-04-24 Boehringer Mannheim Gmbh, 6800 Mannheim Adenosin-Derivate und Verfahren zu ihrer Herstellung
SE361760B (ko) * 1972-04-05 1973-11-12 Haldex Ab
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
US4373097A (en) * 1981-04-27 1983-02-08 Bioresearch S.R.L. Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity
EP0305643B1 (en) * 1984-04-18 1994-01-05 Whitby Research Incorporated N-6 thienyl substituted adenosine derivatives as cardiac vasodilators
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
AU577743B2 (en) * 1984-10-26 1988-09-29 Warner-Lambert Company N6-benzopyrano and benzothiopyrano adenosines

Also Published As

Publication number Publication date
DK488485D0 (da) 1985-10-24
ES8701774A1 (es) 1986-12-01
CA1260931A (en) 1989-09-26
KR910002226B1 (ko) 1991-04-08
FI854153A0 (fi) 1985-10-23
EP0181129A2 (en) 1986-05-14
AU575438B2 (en) 1988-07-28
CN85108658A (zh) 1986-07-16
DK488485A (da) 1986-04-27
NO854278L (no) 1986-04-28
NO165495B (no) 1990-11-12
FI854153L (fi) 1986-04-27
NO165495C (no) 1991-02-20
CN1013448B (zh) 1991-08-07
EP0181129A3 (en) 1987-05-13
PT81373B (pt) 1987-11-11
GR852583B (ko) 1986-02-26
AU4888885A (en) 1986-05-08
DE3568582D1 (en) 1989-04-13
ES548238A0 (es) 1986-12-01
NZ213971A (en) 1988-03-30
FI81587B (fi) 1990-07-31
FI81587C (fi) 1990-11-12
EP0181129B1 (en) 1989-03-08
PT81373A (en) 1985-11-01

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