KR860002576A - 신규 항생 물질 화합물의 제조방법 - Google Patents
신규 항생 물질 화합물의 제조방법 Download PDFInfo
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- KR860002576A KR860002576A KR1019850006691A KR850006691A KR860002576A KR 860002576 A KR860002576 A KR 860002576A KR 1019850006691 A KR1019850006691 A KR 1019850006691A KR 850006691 A KR850006691 A KR 850006691A KR 860002576 A KR860002576 A KR 860002576A
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- C—CHEMISTRY; METALLURGY
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 인자 A의 IR스펙트럼을 나타낸 것임.
제2도는 인자 B의 IR스펙트럼을 나타낸 것임.
제3도는 인자 C의 IR스펙트럼을 나타낸 것임.
Claims (26)
- 스트랩토 마이세스속의 미생물을 배양시켜서 하기 화합물을 제조하고, 이어서, 필요에 따라서 발효액으로 부터 하기 구조식(Ⅰ)의 화합물중 적어도 1개 이상의 화합물을 분리시킴을 특징으로 하는 하기 부분 구족식(Ⅰ)을 갖는 화합물의 제조방법.
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- 제1항에 있어서, 하기 부분 구조식(Ⅱ)을 갖는 화합물을 제조하는 방법.
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- 제2항에 있어서, 하기 일반식(Ⅲ)을 갖는 화합물을 제조하는 방법.
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- (식중, R1은 메틸, 에틸 또는 이소프로필기이고, R2는 수소 또는 메틸기임.)
- 제3항에 있어서, 제조된 화합물중 R1이 이소프로필기이고, R2가 수소인 방법.
- 제3항에 있어서, 제조된 화합물중 R1이 메틸기이고, R2가 수소인 방법.
- 전 항중 어느 한 항에 있어서, 미생물이 주로 제1항에서 정의한 바와 같은 구조식(Ⅰ)의 화합물중 1개 이상의 화합물을 생성하는 방법.
- 전 항중 어느 한 항에 있어서, 미생물이 스트렙토마이세스 더모아르카엔시스인 방법.
- 전 항중 어느 한 항에 있어서, 미생물이 스트렙토마이세스속 더모아르카엔시스 NCIB 12015또는 그의 돌연변이체인 방법.
- 전 항중 어느 한 항에 있어서, 미생물이 스트렙토마이세스 더모아르카엔시스 NCIB 12111, NCIB12112, NCIB 12113 또는 NCIB 12114 또는 그의 돌연변이체인 방법.
- 전 항중 어느 한 항에 있어서, 미생물을 20°-50℃에서 배양시키는 방법.
- 전 항중 어느 한 항에 있어서, 미생물을 pH 5.5 내지 8.5에서 발효시키는 방법.
- 전 항중 어느 한 항에 있어서, 미생물을 2 내지 10일동안 발효시키는 방법.
- 전 항중 어느 한 항에 있어서, 미생물의 균사를 물과 혼화시킬수 있는 용매와 접촉시켜서 그로부터 제1항의 화합물중 1개이상의 화합물을 추출시키는 방법.
- 전 항중 어느 한 항에 있어서, 일반식(Ⅰ)의 화합물을 실질적으로 순수한 형태로 제조하는 방법.
- 제1 내지 13항중의 어느 한 항에 있어서, 일반식(Ⅰ)의 화합물을 실질적으로 기타 마크로리드 화합물의 부재하에서 제조하는 방법.
- 제1 내지 13항중의 어느 한 항에 있어서, 제3항에서 정의된 바와 같은 화합물의 혼합물, 또는 R2가 수소인 제3항에서 정의된 바와 같은 화합물들의 혼합물, 또는 R2가 메틸기인 제3항에서 정의된 바와 같은 화합물들의 혼합물을 제조하는 방법.
- 제1 내지 12항중의 어느 한 항에 있어서, 생성물이 제1항에서 정의한 바와 같은 구조식(Ⅰ)의 1가지 상의 화합물을 함유하는 완전한 발효액, 이와 같은 완전한 발효액의 고상물, 발효액으로부터 분리시킨 손상되지 않거나 또는 용해된 균사, 손상되지 않거나 또는 용해된 균사를 분리시킨 후 발효액의 고상물, 또는 균사를 분리시킨 후의 발효액 형태인 방법.
- 제1-5항중 어느 하나에서 정의한 1개 이상의 화합물과 1개이상의 담체 또는 부형체, 필요에 따라서 1개 이상의 첨가제, 또는 추가 유효성분을 혼합하거나 또는 다른 방식으로 제제해서 감염 또는 침습을 방제하기 위한 조성물의 제조방법.
- 제1-5항중 어느 하나에서 정의한 1개 이상의 화합물의 유효량을 감염, 침습 또는 그 부위에 원인이 되는 기생충, 기타 해충, 진균류 또는 미생물에 사용해서 감염 또는 침습(예, 농업, 원예 또는 임업)을 방제시키는 방법.
- 제19항에 있어서, 상기 화합물을 식물, 기타 초목, 또는 선택된 그 부위에 사용하는것을 특징으로 하는 방법.
- 제19 내지 20항에 있어서, 상기 기생충이 곤충, 진드기, 또는 선충류, 해충인 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8423278 | 1984-09-14 | ||
GB848423278A GB8423278D0 (en) | 1984-09-14 | 1984-09-14 | Antibiotic compounds |
GB8432519 | 1984-12-21 | ||
GB848432519A GB8432519D0 (en) | 1984-12-21 | 1984-12-21 | Antibiotic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860002576A true KR860002576A (ko) | 1986-04-26 |
KR940004098B1 KR940004098B1 (ko) | 1994-05-13 |
Family
ID=26288220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850006691A KR940004098B1 (ko) | 1984-09-14 | 1985-09-13 | 신규 항생제 화합물의 제조 방법 |
Country Status (33)
Country | Link |
---|---|
US (2) | US4898821A (ko) |
JP (2) | JPH07116199B2 (ko) |
KR (1) | KR940004098B1 (ko) |
AT (1) | AT396250B (ko) |
AU (1) | AU596565B2 (ko) |
BE (1) | BE903232A (ko) |
BG (1) | BG44205A3 (ko) |
BR (1) | BR8504457A (ko) |
CA (1) | CA1313155C (ko) |
CH (1) | CH666690A5 (ko) |
CS (1) | CS268803B2 (ko) |
DE (1) | DE3532794A1 (ko) |
DK (1) | DK162099C (ko) |
ES (2) | ES8704545A1 (ko) |
FI (1) | FI87366C (ko) |
FR (1) | FR2570390B1 (ko) |
GB (1) | GB2166436B (ko) |
GR (1) | GR852232B (ko) |
HU (1) | HU197046B (ko) |
IE (1) | IE59394B1 (ko) |
IL (1) | IL76385A (ko) |
IT (1) | IT1182857B (ko) |
LU (1) | LU86074A1 (ko) |
NL (1) | NL8502511A (ko) |
NZ (1) | NZ213463A (ko) |
PH (2) | PH21995A (ko) |
PL (1) | PL152148B1 (ko) |
PT (1) | PT81125B (ko) |
RO (1) | RO92478A (ko) |
SE (2) | SE502748C2 (ko) |
SU (1) | SU1738090A3 (ko) |
UA (1) | UA19162A (ko) |
ZW (1) | ZW15585A1 (ko) |
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US4696922A (en) * | 1984-11-26 | 1987-09-29 | Ciba-Geigy Corporation | 5-azolylacetoxymilbemycins as ecto- and endoparasites |
AT399441B (de) * | 1985-04-30 | 1995-05-26 | American Cyanamid Co | Schädlingsbekämpfungsmittel und verfahren zur bekämpfung von schädlingen |
ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
EP0215654B1 (en) * | 1985-09-13 | 1995-03-15 | American Cyanamid Company | Macrolide antibiotics and their preparation |
AT398312B (de) * | 1986-03-12 | 1994-11-25 | American Cyanamid Co | Verfahren zur herstellung einer neuen makroliden verbindung |
NZ219575A (en) * | 1986-03-12 | 1990-04-26 | Glaxo Group Ltd | Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions |
GB8606116D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Process |
GB8606120D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Process |
DE3707859A1 (de) * | 1986-03-12 | 1987-10-08 | Glaxo Group Ltd | Makrolidverbindung |
GB8606105D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Chemical compounds |
GB8613790D0 (en) * | 1986-06-06 | 1986-07-09 | Glaxo Group Ltd | Chemical compounds |
CA1296329C (en) * | 1986-06-06 | 1992-02-25 | Derek R. Sutherland | Macrolide compounds |
US5840704A (en) * | 1986-07-16 | 1998-11-24 | Pfizer Inc. | Antiparasitic agents and process for their preparation |
NZ221077A (en) * | 1986-07-18 | 1990-06-26 | Ciba Geigy Ag | 13b-alkyl milbemycins and use as parasiticides |
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US5149832A (en) * | 1986-09-12 | 1992-09-22 | American Cyanamid Company | Mono and diacyl derivatives of ll-f28249 compounds |
ATE109783T1 (de) * | 1986-09-12 | 1994-08-15 | American Cyanamid Co | 23-oxo(keto) und 23-imino-derivate von ll-f28249- verbindungen. |
EP0262384B1 (en) * | 1986-09-12 | 1992-11-04 | American Cyanamid Company | 23-deoxy derivatives of ll-f28249 compounds |
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MD24B1 (ro) * | 1991-07-09 | 1994-05-31 | Parfumerii Si Cosmetice Vioric | Compozitie de substante odorante |
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SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
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US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
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ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
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1985
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- 1985-09-13 JP JP60201951A patent/JPH07116199B2/ja not_active Expired - Lifetime
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- 1985-09-13 LU LU86074A patent/LU86074A1/fr unknown
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- 1985-09-13 KR KR1019850006691A patent/KR940004098B1/ko not_active IP Right Cessation
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1986
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1987
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1988
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1995
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