KR850008344A - 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 - Google Patents
일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 Download PDFInfo
- Publication number
- KR850008344A KR850008344A KR1019850003565A KR850003565A KR850008344A KR 850008344 A KR850008344 A KR 850008344A KR 1019850003565 A KR1019850003565 A KR 1019850003565A KR 850003565 A KR850003565 A KR 850003565A KR 850008344 A KR850008344 A KR 850008344A
- Authority
- KR
- South Korea
- Prior art keywords
- macromolecule
- thiol group
- ionophore
- antibody
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8408073A FR2564839B1 (fr) | 1984-05-23 | 1984-05-23 | Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines |
FR8408073 | 1984-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR850008344A true KR850008344A (ko) | 1985-12-16 |
Family
ID=9304319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850003565A KR850008344A (ko) | 1984-05-23 | 1985-05-23 | 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS6156198A (fr) |
KR (1) | KR850008344A (fr) |
FR (1) | FR2564839B1 (fr) |
ZA (1) | ZA853793B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110167577B (zh) * | 2016-11-16 | 2024-05-10 | 普渡研究基金会 | 配体离子载体共轭物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5764617A (en) * | 1980-10-08 | 1982-04-19 | Teijin Ltd | Cytotoxic proteinic complex and its preparation |
FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
FR2521010B1 (fr) * | 1982-02-09 | 1985-07-19 | Sanofi Sa | Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent |
JPS58167519A (ja) * | 1982-03-30 | 1983-10-03 | Teijin Ltd | 細胞毒性複合体及びその製造法 |
JPS5942323A (ja) * | 1982-09-02 | 1984-03-08 | Teijin Ltd | 選択的殺細胞性蛋白複合体及びその製造方法 |
-
1984
- 1984-05-23 FR FR8408073A patent/FR2564839B1/fr not_active Expired
-
1985
- 1985-05-20 ZA ZA853793A patent/ZA853793B/xx unknown
- 1985-05-23 JP JP60111285A patent/JPS6156198A/ja active Pending
- 1985-05-23 KR KR1019850003565A patent/KR850008344A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA853793B (en) | 1986-01-29 |
JPS6156198A (ja) | 1986-03-20 |
FR2564839B1 (fr) | 1986-11-14 |
FR2564839A1 (fr) | 1985-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |