FR2564839B1 - Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines - Google Patents

Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines

Info

Publication number
FR2564839B1
FR2564839B1 FR8408073A FR8408073A FR2564839B1 FR 2564839 B1 FR2564839 B1 FR 2564839B1 FR 8408073 A FR8408073 A FR 8408073A FR 8408073 A FR8408073 A FR 8408073A FR 2564839 B1 FR2564839 B1 FR 2564839B1
Authority
FR
France
Prior art keywords
potentializers
immunotoxins
macromolecule
covalent binding
monovalent carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8408073A
Other languages
English (en)
Other versions
FR2564839A1 (fr
Inventor
Franz K Jansen
Pierre Gros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8408073A priority Critical patent/FR2564839B1/fr
Priority to CA000481505A priority patent/CA1314245C/fr
Priority to IL8913885A priority patent/IL89138A/xx
Priority to IL75228A priority patent/IL75228A/xx
Priority to NZ212118A priority patent/NZ212118A/en
Priority to GR851229A priority patent/GR851229B/el
Priority to ZA853793A priority patent/ZA853793B/xx
Priority to NZ22798585A priority patent/NZ227985A/en
Priority to DE8585400998T priority patent/DE3571928D1/de
Priority to DK224785A priority patent/DK164457C/da
Priority to AT85400998T priority patent/ATE45092T1/de
Priority to EP85400998A priority patent/EP0162781B1/fr
Priority to PT80501A priority patent/PT80501B/fr
Priority to IE127985A priority patent/IE58480B1/en
Priority to ES543367A priority patent/ES8604228A1/es
Priority to JP60111285A priority patent/JPS6156198A/ja
Priority to KR1019850003565A priority patent/KR850008344A/ko
Priority to AU42793/85A priority patent/AU600651B2/en
Publication of FR2564839A1 publication Critical patent/FR2564839A1/fr
Application granted granted Critical
Publication of FR2564839B1 publication Critical patent/FR2564839B1/fr
Priority to US07/034,712 priority patent/US4919928A/en
Priority to IL89138A priority patent/IL89138A0/xx
Priority to US07/457,858 priority patent/US4977280A/en
Priority to US07/458,444 priority patent/US5144009A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR8408073A 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines Expired FR2564839B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR8408073A FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines
CA000481505A CA1314245C (fr) 1984-05-23 1985-05-14 Methode de preparation de conjugues formes d'un ionophore carboxylique monovalent associe par une liaison de covalence a une macromolecule et utiles comme agents de potentialisation d'immunotoxines
IL8913885A IL89138A (en) 1984-05-23 1985-05-17 Activated carboxylic ionophores containing a thiol group
IL75228A IL75228A (en) 1984-05-23 1985-05-17 Conjugates in which certain nonovalent carboxylic ionophores are covalently bonded to a macromolecule,their preparation and pharmaceutical compositions containing them as immunotoxin potentiators
GR851229A GR851229B (fr) 1984-05-23 1985-05-20
ZA853793A ZA853793B (en) 1984-05-23 1985-05-20 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores
NZ22798585A NZ227985A (en) 1984-05-23 1985-05-20 Intermediate activated ionophores carrying a thiol group
NZ212118A NZ212118A (en) 1984-05-23 1985-05-20 Conjugate of macromolecule and ionophore; use as immunotoxin potentiator
AT85400998T ATE45092T1 (de) 1984-05-23 1985-05-21 Conjugierte derivate, assoziiert durch covalente bindungen mit einem monovalenten carbonylionophor, ihre verwendung als potentialisatoren von immunotoxinen und activierte ionophore zwischenverbindungen.
DK224785A DK164457C (da) 1984-05-23 1985-05-21 Konjugater, hvor en monovalent carboxylionophor ved hjaelp af en kovalent binding er knyttet til et makromolekyle, fremgangsmaade til fremstilling af konjugaterne og disses anvendelse som immunotoksinpotentiatorer
DE8585400998T DE3571928D1 (en) 1984-05-23 1985-05-21 Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores
EP85400998A EP0162781B1 (fr) 1984-05-23 1985-05-21 Conjugués associant par liaison covalente un ionophore carboxylique monovalent et une macromolécule, leur utilisation comme agents potentialisateurs des immunotoxines et les ionophores activés intermédiaires
PT80501A PT80501B (fr) 1984-05-23 1985-05-21 Procede pour l'obtention de conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule utiles comme agents potentialiseurs des immunotoxines
ES543367A ES8604228A1 (es) 1984-05-23 1985-05-22 Procedimiento para la obtencion de un conjugado entre un io-nofero carboxilico monovalente y una macromolecula
IE127985A IE58480B1 (en) 1984-05-23 1985-05-22 Conjugates of monovalent carboxylic ionophores and macromolecules
KR1019850003565A KR850008344A (ko) 1984-05-23 1985-05-23 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법
JP60111285A JPS6156198A (ja) 1984-05-23 1985-05-23 イオノフオアと高分子とをカツプリングさせた包合体およびその使用法
AU42793/85A AU600651B2 (en) 1984-05-23 1985-05-23 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores
US07/034,712 US4919928A (en) 1984-05-23 1987-04-06 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores
IL89138A IL89138A0 (en) 1984-05-23 1989-02-01 Activated carboxylic ionophores containing a thiol group
US07/457,858 US4977280A (en) 1984-05-23 1989-12-27 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores
US07/458,444 US5144009A (en) 1984-05-23 1989-12-28 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated inophores

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8408073A FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines

Publications (2)

Publication Number Publication Date
FR2564839A1 FR2564839A1 (fr) 1985-11-29
FR2564839B1 true FR2564839B1 (fr) 1986-11-14

Family

ID=9304319

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8408073A Expired FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines

Country Status (4)

Country Link
JP (1) JPS6156198A (fr)
KR (1) KR850008344A (fr)
FR (1) FR2564839B1 (fr)
ZA (1) ZA853793B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3541403A4 (fr) * 2016-11-16 2020-08-12 Purdue Research Foundation Conjugués ligand-ionophore

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5764617A (en) * 1980-10-08 1982-04-19 Teijin Ltd Cytotoxic proteinic complex and its preparation
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2521010B1 (fr) * 1982-02-09 1985-07-19 Sanofi Sa Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent
JPS58167519A (ja) * 1982-03-30 1983-10-03 Teijin Ltd 細胞毒性複合体及びその製造法
JPS5942323A (ja) * 1982-09-02 1984-03-08 Teijin Ltd 選択的殺細胞性蛋白複合体及びその製造方法

Also Published As

Publication number Publication date
JPS6156198A (ja) 1986-03-20
FR2564839A1 (fr) 1985-11-29
KR850008344A (ko) 1985-12-16
ZA853793B (en) 1986-01-29

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