KR850000030A - 아스파르탐의 제조방법 - Google Patents
아스파르탐의 제조방법 Download PDFInfo
- Publication number
- KR850000030A KR850000030A KR1019840002999A KR840002999A KR850000030A KR 850000030 A KR850000030 A KR 850000030A KR 1019840002999 A KR1019840002999 A KR 1019840002999A KR 840002999 A KR840002999 A KR 840002999A KR 850000030 A KR850000030 A KR 850000030A
- Authority
- KR
- South Korea
- Prior art keywords
- aspartame
- phosphoric acid
- methyl ester
- aspartyl
- formyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- N-포르밀-L-아스파르트산 무수물과 L-페닐알라닌 메틸 에스테르를 축합시켜 얻어진 N-포르밀-L-아스파르틸-L-페닐-알라닌 메틸에스테르의 α-및 β-이성체의 조혼합물을 아세트산 존재하에서 에틸아세테이트 또는 디클로로에탄과 같은 유기용매중에 용해시킨다음 인산과 저급 알킬 알코올로 처리하여 거의 용해되지 않는 아스파르탐 인산염을 수득하고, 이를 여과하여 모으고 물에 용해시킨 다음 무기 염기를 사용하여 중화시켜서 목적하는 순수한 유리 아스파르탐을 높은 수율로 수득함을 특징으로 하여 N-L-α-아스파르틸-L-페닐알라닌-1-메틸 에스테르(아스파르탐)를 제조하는 방법.
- 제1항에 있어서, 인산의 농도가 물 중에서 50% 내지 99%, 바람직하게는 85%임을 특징으로 하는 방법.
- 제1항에 있어서, 인산의 양이 탈 포르밀화 될 N-보호된 아스파르탐의 몰당 1.2 내지 5몰임을 특징으로 하는 방법.
- 제1항에 있어서, 저급 알킬 알코올이 탄소수 1 내지 4이고, 바람직하게는 메틸알코올임을 특징으로 하는 방법.
- 제1항에 있어서, 반응을 실온 내지 60℃의 온도에서, 4내지 12시간 동안 수행함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8314907 | 1983-05-31 | ||
GB838314907A GB8314907D0 (en) | 1983-05-31 | 1983-05-31 | Aspartame synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850000030A true KR850000030A (ko) | 1985-02-25 |
KR910002387B1 KR910002387B1 (ko) | 1991-04-20 |
Family
ID=10543585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840002999A KR910002387B1 (ko) | 1983-05-31 | 1984-05-30 | 아스파르탐의 제조방법 |
Country Status (29)
Country | Link |
---|---|
US (1) | US4656304A (ko) |
JP (1) | JPS59227850A (ko) |
KR (1) | KR910002387B1 (ko) |
AT (1) | AT387024B (ko) |
AU (1) | AU561593B2 (ko) |
BE (1) | BE899783A (ko) |
CA (1) | CA1244008A (ko) |
CH (1) | CH659061A5 (ko) |
CS (1) | CS257778B2 (ko) |
DE (1) | DE3419921A1 (ko) |
DK (1) | DK163928C (ko) |
ES (1) | ES532916A0 (ko) |
FI (1) | FI80465C (ko) |
FR (1) | FR2547816B1 (ko) |
GB (1) | GB8314907D0 (ko) |
GR (1) | GR82034B (ko) |
HU (1) | HU191146B (ko) |
IE (2) | IE810577L (ko) |
IL (1) | IL71930A (ko) |
IT (1) | IT1212097B (ko) |
NL (1) | NL192112C (ko) |
NO (1) | NO163738C (ko) |
NZ (1) | NZ208279A (ko) |
PH (1) | PH21764A (ko) |
PT (1) | PT78657B (ko) |
SE (1) | SE459176B (ko) |
SU (1) | SU1342423A3 (ko) |
YU (1) | YU44456B (ko) |
ZA (1) | ZA844071B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0680075B2 (ja) * | 1985-12-24 | 1994-10-12 | 味の素株式会社 | N―ホルミル―α―L―アスパルチル―L―フェニルアラニンメチルエステルの製造法 |
JP2662287B2 (ja) * | 1988-03-14 | 1997-10-08 | 三井東圧化学株式会社 | α―L―アスパルチル―L―フェニルアラニンメチルエステルの分離方法 |
US5283357A (en) * | 1988-03-14 | 1994-02-01 | Mitsui Toatsu Chemicals, Incorporated | Separation method of α-l-aspartyl-l-phenylalanine methyl ester |
US5017690A (en) * | 1989-08-11 | 1991-05-21 | W. R. Grace & Co.-Conn. | Deblocking N-formyl aspartame compounds |
NL9201408A (nl) * | 1992-08-05 | 1994-03-01 | Holland Sweetener Co | Werkwijze voor het kristalliseren van aspartaam. |
BE1010071A3 (nl) * | 1996-04-10 | 1997-12-02 | Holland Sweetener Co | Aspartaam op drager. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3492131A (en) * | 1966-04-18 | 1970-01-27 | Searle & Co | Peptide sweetening agents |
JPS5140069B1 (ko) * | 1971-07-09 | 1976-11-01 | ||
US3833553A (en) * | 1970-01-31 | 1974-09-03 | Ajinomoto Kk | Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters |
BE791544A (fr) * | 1971-11-19 | 1973-05-17 | Stamicarbon | Preparation d'esters alkyliques de dipeptide |
JPS5113737A (en) * | 1974-07-23 | 1976-02-03 | Ajinomoto Kk | Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho |
JPS5223001A (en) * | 1975-08-14 | 1977-02-21 | Ajinomoto Co Inc | Process for elimination of formyl group |
US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
JPS57131746A (en) * | 1981-02-10 | 1982-08-14 | Ajinomoto Co Inc | Removal of n-formyl group |
JPS58185545A (ja) * | 1982-04-22 | 1983-10-29 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法 |
-
1981
- 1981-03-16 IE IE810577A patent/IE810577L/xx unknown
-
1983
- 1983-05-31 GB GB838314907A patent/GB8314907D0/en active Pending
-
1984
- 1984-05-15 FI FI841952A patent/FI80465C/fi not_active IP Right Cessation
- 1984-05-24 AT AT0172384A patent/AT387024B/de not_active IP Right Cessation
- 1984-05-24 FR FR8408119A patent/FR2547816B1/fr not_active Expired
- 1984-05-24 GR GR74819A patent/GR82034B/el unknown
- 1984-05-25 IL IL71930A patent/IL71930A/xx unknown
- 1984-05-25 NZ NZ208279A patent/NZ208279A/en unknown
- 1984-05-25 NL NL8401674A patent/NL192112C/nl not_active IP Right Cessation
- 1984-05-25 US US06/614,150 patent/US4656304A/en not_active Expired - Fee Related
- 1984-05-25 CA CA000455169A patent/CA1244008A/en not_active Expired
- 1984-05-25 SU SU843743902A patent/SU1342423A3/ru active
- 1984-05-25 IE IE1312/84A patent/IE57662B1/en not_active IP Right Cessation
- 1984-05-28 AU AU28767/84A patent/AU561593B2/en not_active Ceased
- 1984-05-28 HU HU842057A patent/HU191146B/hu not_active IP Right Cessation
- 1984-05-28 CS CS843998A patent/CS257778B2/cs unknown
- 1984-05-28 DE DE3419921A patent/DE3419921A1/de active Granted
- 1984-05-28 PT PT78657A patent/PT78657B/pt not_active IP Right Cessation
- 1984-05-29 NO NO842129A patent/NO163738C/no unknown
- 1984-05-29 BE BE0/213030A patent/BE899783A/fr not_active IP Right Cessation
- 1984-05-29 ES ES532916A patent/ES532916A0/es active Granted
- 1984-05-29 IT IT8421147A patent/IT1212097B/it active
- 1984-05-29 JP JP59107667A patent/JPS59227850A/ja active Granted
- 1984-05-29 PH PH30733A patent/PH21764A/en unknown
- 1984-05-29 ZA ZA844071A patent/ZA844071B/xx unknown
- 1984-05-29 CH CH2630/84A patent/CH659061A5/it not_active IP Right Cessation
- 1984-05-30 YU YU922/84A patent/YU44456B/xx unknown
- 1984-05-30 SE SE8402953A patent/SE459176B/sv not_active IP Right Cessation
- 1984-05-30 DK DK270084A patent/DK163928C/da not_active IP Right Cessation
- 1984-05-30 KR KR1019840002999A patent/KR910002387B1/ko not_active IP Right Cessation
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