ES8506598A1 - Un procedimiento para la preparacion del ester 1-metilico de la n-l -aspartil-l-fenilalanina (aspartamo) - Google Patents

Un procedimiento para la preparacion del ester 1-metilico de la n-l -aspartil-l-fenilalanina (aspartamo)

Info

Publication number
ES8506598A1
ES8506598A1 ES532916A ES532916A ES8506598A1 ES 8506598 A1 ES8506598 A1 ES 8506598A1 ES 532916 A ES532916 A ES 532916A ES 532916 A ES532916 A ES 532916A ES 8506598 A1 ES8506598 A1 ES 8506598A1
Authority
ES
Spain
Prior art keywords
aspartame
aspartyl
alpha
methyl ester
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532916A
Other languages
English (en)
Other versions
ES532916A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8506598A1 publication Critical patent/ES8506598A1/es
Publication of ES532916A0 publication Critical patent/ES532916A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DEL ESTER 1-METILICO DE LA N-L-BAB-ASPARTIL-L-FENILALANINA (ASPARTAMO).COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, LA MEZCLA BRUTA DE LOS ISOMEROS BAB Y BBB DEL ESTER METILICO DE LA N-FORMIL-L-ASPARTIL-L-FENIL-ALANINA, SE OBTIENE POR CONDENSACION ENTRE EL ANHIDRIDO N-FORMIL-L-ASPARTICO Y EL ESTER METILICO DE LA L-FENILALANINA; SEGUNDA, DICHA MEZCLA BRUTA SE DISUELVE EN UN DISOLVENTE ORGANICO TAL COMO EL ACETATO DE ETILO Y EN PRESENCIA DE ACIDO ACETICO, Y A CONTINUACION SE TRATA CON ACIDO FOSFORICO Y CON UN ALCOHOL ALQUILICO INFERIOR, PARA OBTENER EL FOSFATO DE ASPARTAMO; Y POR ULTIMO, EL FOSFATO DE ASPARTAMO OBTENIDO SE DISUELVE EN AGUA Y SE NEUTRALIZA SEGUIDAMENTE UTILIZANDO UNA BASE INORGANICA, PARA OBTENER EL ASPARTAMO LIBRE Y PURO.DE APLICACION COMO AGENTE EDULCORANTE EN ALIMENTOS Y BEBIDAS.
ES532916A 1983-05-31 1984-05-29 Un procedimiento para la preparacion del ester 1-metilico de la n-l -aspartil-l-fenilalanina (aspartamo) Granted ES532916A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838314907A GB8314907D0 (en) 1983-05-31 1983-05-31 Aspartame synthesis

Publications (2)

Publication Number Publication Date
ES8506598A1 true ES8506598A1 (es) 1985-08-01
ES532916A0 ES532916A0 (es) 1985-08-01

Family

ID=10543585

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532916A Granted ES532916A0 (es) 1983-05-31 1984-05-29 Un procedimiento para la preparacion del ester 1-metilico de la n-l -aspartil-l-fenilalanina (aspartamo)

Country Status (29)

Country Link
US (1) US4656304A (es)
JP (1) JPS59227850A (es)
KR (1) KR910002387B1 (es)
AT (1) AT387024B (es)
AU (1) AU561593B2 (es)
BE (1) BE899783A (es)
CA (1) CA1244008A (es)
CH (1) CH659061A5 (es)
CS (1) CS257778B2 (es)
DE (1) DE3419921A1 (es)
DK (1) DK163928C (es)
ES (1) ES532916A0 (es)
FI (1) FI80465C (es)
FR (1) FR2547816B1 (es)
GB (1) GB8314907D0 (es)
GR (1) GR82034B (es)
HU (1) HU191146B (es)
IE (2) IE810577L (es)
IL (1) IL71930A (es)
IT (1) IT1212097B (es)
NL (1) NL192112C (es)
NO (1) NO163738C (es)
NZ (1) NZ208279A (es)
PH (1) PH21764A (es)
PT (1) PT78657B (es)
SE (1) SE459176B (es)
SU (1) SU1342423A3 (es)
YU (1) YU44456B (es)
ZA (1) ZA844071B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
US5283357A (en) * 1988-03-14 1994-02-01 Mitsui Toatsu Chemicals, Incorporated Separation method of α-l-aspartyl-l-phenylalanine methyl ester
JP2662287B2 (ja) * 1988-03-14 1997-10-08 三井東圧化学株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの分離方法
US5017690A (en) * 1989-08-11 1991-05-21 W. R. Grace & Co.-Conn. Deblocking N-formyl aspartame compounds
NL9201408A (nl) * 1992-08-05 1994-03-01 Holland Sweetener Co Werkwijze voor het kristalliseren van aspartaam.
BE1010071A3 (nl) * 1996-04-10 1997-12-02 Holland Sweetener Co Aspartaam op drager.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
US3833553A (en) * 1970-01-31 1974-09-03 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters
JPS5140069B1 (es) * 1971-07-09 1976-11-01
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法

Also Published As

Publication number Publication date
ATA172384A (de) 1988-04-15
NZ208279A (en) 1987-04-30
SE459176B (sv) 1989-06-12
NL192112B (nl) 1996-10-01
IT8421147A0 (it) 1984-05-29
DK270084A (da) 1984-12-01
IL71930A0 (en) 1984-09-30
SE8402953D0 (sv) 1984-05-30
AU561593B2 (en) 1987-05-14
IL71930A (en) 1986-12-31
FI841952A (fi) 1984-12-01
CS257778B2 (en) 1988-06-15
HUT34434A (en) 1985-03-28
DK270084D0 (da) 1984-05-30
DK163928C (da) 1992-09-14
IT1212097B (it) 1989-11-08
JPH0570638B2 (es) 1993-10-05
IE841312L (en) 1984-11-30
CH659061A5 (it) 1986-12-31
FR2547816A1 (fr) 1984-12-28
HU191146B (en) 1987-01-28
NO163738B (no) 1990-04-02
US4656304A (en) 1987-04-07
YU44456B (en) 1990-08-31
NO163738C (no) 1990-07-11
BE899783A (fr) 1984-09-17
ZA844071B (en) 1984-12-24
SE8402953L (sv) 1984-12-01
PH21764A (en) 1988-02-18
FI80465C (fi) 1990-06-11
FR2547816B1 (fr) 1987-10-30
NL8401674A (nl) 1984-12-17
CS399884A2 (en) 1987-11-12
DE3419921A1 (de) 1984-12-13
FI841952A0 (fi) 1984-05-15
ES532916A0 (es) 1985-08-01
PT78657A (en) 1984-06-01
FI80465B (fi) 1990-02-28
AU2876784A (en) 1984-12-06
NL192112C (nl) 1997-02-04
IE810577L (en) 1982-09-16
GB8314907D0 (en) 1983-07-06
KR910002387B1 (ko) 1991-04-20
PT78657B (en) 1986-09-08
DK163928B (da) 1992-04-21
DE3419921C2 (es) 1989-04-20
SU1342423A3 (ru) 1987-09-30
IE57662B1 (en) 1993-02-24
YU92284A (en) 1986-10-31
JPS59227850A (ja) 1984-12-21
KR850000030A (ko) 1985-02-25
CA1244008A (en) 1988-11-01
GR82034B (es) 1984-12-12
NO842129L (no) 1984-12-03
AT387024B (de) 1988-11-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202