KR850000026A - 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물 - Google Patents
바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물 Download PDFInfo
- Publication number
- KR850000026A KR850000026A KR1019840003111A KR840003111A KR850000026A KR 850000026 A KR850000026 A KR 850000026A KR 1019840003111 A KR1019840003111 A KR 1019840003111A KR 840003111 A KR840003111 A KR 840003111A KR 850000026 A KR850000026 A KR 850000026A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- iii
- composition
- active ingredient
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
- B65H3/00—Separating articles from piles
- B65H3/02—Separating articles from piles using friction forces between articles and separator
- B65H3/06—Rollers or like rotary separators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/12—Saturated polycyclic compounds
- C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
- C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 식(Ⅱ)의 메틸 8-옥소-바이사이클로(3.2.1) 옥탄-3-카르복실산염을 환원 및 가수분해를 통하여 식(Ⅲ)의 산으로 전환하고, 식(Ⅲ)의 산을 강염기와 반응시켜 식(Ⅳ)의 중간체 유기금속 화합물을 생성하고 화합물(Ⅳ)을 할로겐화 알킬의 작용으로 Z가 OH를 나타내는 식(I)의 화합물을 제조하는 방법.
- 식(Ⅲ)의 유도체가 메틸 8-옥소-바이사이클로(3.2.1) 옥탄-3-카르복실산 염을 수산화칼륨 및 히드라진과 반응시켜 제조되는 특허청구의 범위 제1항에 따른 방법.
- 식(Ⅲ)의 산을 니트릴 또는 에스테르와 치환하여 식(V)의 화합물을 얻고 그 다음에 식(I)의 화합물로 전환하는 특허청구의 범위 제1항에 따른 방법.
- 특허청구의 범위 제1항에 주장된 화합물이 활성성분으로 항경련 및 항혈액 산소 결핍증 활성을 가진 조성물.
- 경구, 비경구 또는 직장 투여시 활성성분이 투여 가능한 형태로 조성될 수 있는 특허청구의 범위 제4항에 따른 조성물.
- 단위 투여 형태에서 각 단위 투여량이 활성성분을 0.050-0.500g 포함한 특허청구의 범위 제5항에 따른 조성물.여기서 R은 곧은 또는 가지달린 사슬 저급 알킬 라디칼을 나타낸다. Z는 OH기를 나타낸다.여기서 B는 알칼리 금속이다.여기서 Y는 니트릴 또는 에스테르기를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8310612 | 1983-06-22 | ||
FR8310612A FR2547814B1 (fr) | 1983-06-22 | 1983-06-22 | Derives de l'acide bicyclo (3.2.1.) octane carboxylique, leur procede de preparation et leur application therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850000026A true KR850000026A (ko) | 1985-02-25 |
KR870002052B1 KR870002052B1 (ko) | 1987-12-03 |
Family
ID=9290213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840003111A KR870002052B1 (ko) | 1983-06-22 | 1984-06-01 | 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0130882B1 (ko) |
JP (1) | JPS6013741A (ko) |
KR (1) | KR870002052B1 (ko) |
AR (1) | AR242370A1 (ko) |
AT (1) | ATE24711T1 (ko) |
AU (1) | AU564961B2 (ko) |
CA (1) | CA1226584A (ko) |
CS (1) | CS247083B2 (ko) |
DD (1) | DD235447A5 (ko) |
DE (1) | DE3461921D1 (ko) |
DK (1) | DK280284A (ko) |
ES (1) | ES532983A0 (ko) |
FI (1) | FI842538A (ko) |
FR (1) | FR2547814B1 (ko) |
GR (1) | GR82132B (ko) |
HU (1) | HU191677B (ko) |
IL (1) | IL71905A (ko) |
MA (1) | MA20150A1 (ko) |
NO (1) | NO158254C (ko) |
NZ (1) | NZ208607A (ko) |
OA (1) | OA07728A (ko) |
PH (1) | PH22596A (ko) |
PL (1) | PL144486B1 (ko) |
PT (1) | PT78776B (ko) |
YU (1) | YU109684A (ko) |
ZA (1) | ZA844269B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61271025A (ja) * | 1985-05-28 | 1986-12-01 | Agency Of Ind Science & Technol | 横型移動床を用いる粉体の連続処理方法 |
WO1999023056A1 (fr) * | 1997-11-05 | 1999-05-14 | Susanna Askanazovna Saakian | Nouveaux medicaments anti-convulsions |
CN1315692C (zh) * | 2004-12-29 | 2007-05-16 | 大连理工大学 | 快速拆装式双体救捞船 |
US7727978B2 (en) | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6515007A (ko) * | 1964-11-19 | 1966-05-20 |
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1983
- 1983-06-22 FR FR8310612A patent/FR2547814B1/fr not_active Expired
-
1984
- 1984-05-22 AR AR84296726A patent/AR242370A1/es active
- 1984-05-23 IL IL71905A patent/IL71905A/xx not_active IP Right Cessation
- 1984-05-24 CA CA000455080A patent/CA1226584A/fr not_active Expired
- 1984-05-31 ES ES532983A patent/ES532983A0/es active Granted
- 1984-06-01 KR KR1019840003111A patent/KR870002052B1/ko not_active IP Right Cessation
- 1984-06-06 ZA ZA844269A patent/ZA844269B/xx unknown
- 1984-06-07 DK DK280284A patent/DK280284A/da not_active Application Discontinuation
- 1984-06-15 MA MA20374A patent/MA20150A1/fr unknown
- 1984-06-18 AU AU29470/84A patent/AU564961B2/en not_active Ceased
- 1984-06-20 DD DD84264314A patent/DD235447A5/de unknown
- 1984-06-20 PT PT78776A patent/PT78776B/pt unknown
- 1984-06-20 GR GR75066A patent/GR82132B/el unknown
- 1984-06-20 PL PL1984248314A patent/PL144486B1/pl unknown
- 1984-06-20 CS CS844698A patent/CS247083B2/cs unknown
- 1984-06-20 PH PH30857A patent/PH22596A/en unknown
- 1984-06-20 DE DE8484401276T patent/DE3461921D1/de not_active Expired
- 1984-06-20 EP EP84401276A patent/EP0130882B1/fr not_active Expired
- 1984-06-20 AT AT84401276T patent/ATE24711T1/de not_active IP Right Cessation
- 1984-06-21 NO NO842514A patent/NO158254C/no unknown
- 1984-06-21 HU HU842399A patent/HU191677B/hu unknown
- 1984-06-21 NZ NZ208607A patent/NZ208607A/en unknown
- 1984-06-21 FI FI842538A patent/FI842538A/fi not_active Application Discontinuation
- 1984-06-22 YU YU01096/84A patent/YU109684A/xx unknown
- 1984-06-22 OA OA58322A patent/OA07728A/xx unknown
- 1984-06-22 JP JP59129027A patent/JPS6013741A/ja active Granted
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |