ES8102149A1 - Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 - Google Patents

Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2

Info

Publication number
ES8102149A1
ES8102149A1 ES486791A ES486791A ES8102149A1 ES 8102149 A1 ES8102149 A1 ES 8102149A1 ES 486791 A ES486791 A ES 486791A ES 486791 A ES486791 A ES 486791A ES 8102149 A1 ES8102149 A1 ES 8102149A1
Authority
ES
Spain
Prior art keywords
carbon atoms
hydrogen
preparation
pregn
ene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486791A
Other languages
English (en)
Other versions
ES486791A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8102149A1 publication Critical patent/ES8102149A1/es
Publication of ES486791A0 publication Critical patent/ES486791A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 19-NOR-ESTEROIDES SUSTITUIDOS EN POSICION 2, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. SE SOMETE A LA REACCION DE CONDENSACION DE VITTIG UN COMPUESTO DE FORMULA (II), EN LA QUE K Y K'' REPRESENTAN UN GRUPO CETO BLOQUEADO EN FORMA DE CETAL, Y R3 ES UN RADICAL ALCOHILO DE 2 A 4 ATOMOS DE CARBONO, CON UN HALOGENURO DE TRIFENILFOSFONIO, EN PRESENCIA DE UNA BASE FUERTE. EL PRODUCTO RESULTANTE SE HIDROBORA, OXIDA EN MEDIO ALCALINO, DESACETILA Y CICLISA. SE BLOQUEA LA FUNCION ALCOHOL DEL PRODUCTO OBTENIDO EN FORMA DE ETER Y TRATA CON HALURO DE ALCOHILO, ALQUENILO O ALUINILO EN MEDIO BASICO. SE HIDROLIZA Y OXIDA. SE HALOGENA EN POSICION 21 Y ACETOXILA Y, EVENTUALMENTE, SAPONIFICA. SE TRATA CON UN ACIDO, UN DERIVADO FUNCIONAL DE ACIDO QUE CONTIENE DE 1 A 20 ATOMOS DE CARBONO, O UN DERIVADO FUNCIONAL DEL ACIDO FOSFORICO. ESTOS COMPUESTOS TIENEN APLICACION FARMACOLOGICA EN EL TRATAMIENTO DE LA HIPERTENSION ARTERIAL Y LAS INSUFICIENCIAS CARDIACAS. *FORMULA* L
ES486791A 1978-12-13 1979-12-12 Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 Granted ES486791A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7835046A FR2444047A1 (fr) 1978-12-13 1978-12-13 Nouveaux derives 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
ES8102149A1 true ES8102149A1 (es) 1980-12-16
ES486791A0 ES486791A0 (es) 1980-12-16

Family

ID=9216044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486791A Granted ES486791A0 (es) 1978-12-13 1979-12-12 Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2

Country Status (14)

Country Link
US (1) US4263290A (es)
EP (2) EP0044575B1 (es)
JP (1) JPS5585598A (es)
AU (1) AU527582B2 (es)
CA (1) CA1146531A (es)
DK (1) DK527379A (es)
ES (1) ES486791A0 (es)
FI (1) FI70027C (es)
FR (1) FR2444047A1 (es)
HU (1) HU180931B (es)
IE (1) IE49235B1 (es)
PT (1) PT70575A (es)
SU (1) SU1178325A3 (es)
ZA (1) ZA796194B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3229993A (en) * 1992-11-30 1994-06-22 Mallinckrodt Medical, Inc. Steroid-21-phosphate complex of technetium-99m
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
US20090270356A1 (en) * 2008-04-28 2009-10-29 Ceva Sante Animale Sa Compositions and treatments of heart failure in non-human mammal animals
EP2632471B1 (en) 2010-10-27 2019-05-01 Dignity Health Trimegestone (tmg) for treatment of preterm birth

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138460A (en) * 1965-06-01 1969-01-01 Merck & Co Inc Steroid compounds
FR1476572A (fr) * 1965-09-13 1967-04-14 Gonènes synthétiques et leur procédé de préparation
FR2322606A1 (fr) * 1975-09-02 1977-04-01 Roussel Uclaf Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament
FR2364655A1 (fr) * 1976-09-17 1978-04-14 Roussel Uclaf Nouveaux 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
IE792420L (en) 1980-06-13
HU180931B (en) 1983-05-30
DK527379A (da) 1980-06-14
JPS5585598A (en) 1980-06-27
FI793847A (fi) 1980-06-14
FR2444047A1 (fr) 1980-07-11
EP0012641A3 (en) 1980-09-17
FI70027B (fi) 1986-01-31
PT70575A (fr) 1980-01-01
IE49235B1 (en) 1985-09-04
EP0012641B1 (fr) 1982-05-12
EP0044575B1 (fr) 1984-03-21
SU1178325A3 (ru) 1985-09-07
FI70027C (fi) 1986-09-12
FR2444047B1 (es) 1982-05-28
ZA796194B (en) 1980-11-26
AU5376279A (en) 1980-07-10
AU527582B2 (en) 1983-03-10
EP0012641A2 (fr) 1980-06-25
CA1146531A (fr) 1983-05-17
US4263290A (en) 1981-04-21
JPS6337796B2 (es) 1988-07-27
EP0044575A1 (fr) 1982-01-27
ES486791A0 (es) 1980-12-16

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506