ES8102149A1 - Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 - Google Patents
Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2Info
- Publication number
- ES8102149A1 ES8102149A1 ES486791A ES486791A ES8102149A1 ES 8102149 A1 ES8102149 A1 ES 8102149A1 ES 486791 A ES486791 A ES 486791A ES 486791 A ES486791 A ES 486791A ES 8102149 A1 ES8102149 A1 ES 8102149A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- hydrogen
- preparation
- pregn
- ene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 19-NOR-ESTEROIDES SUSTITUIDOS EN POSICION 2, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. SE SOMETE A LA REACCION DE CONDENSACION DE VITTIG UN COMPUESTO DE FORMULA (II), EN LA QUE K Y K'' REPRESENTAN UN GRUPO CETO BLOQUEADO EN FORMA DE CETAL, Y R3 ES UN RADICAL ALCOHILO DE 2 A 4 ATOMOS DE CARBONO, CON UN HALOGENURO DE TRIFENILFOSFONIO, EN PRESENCIA DE UNA BASE FUERTE. EL PRODUCTO RESULTANTE SE HIDROBORA, OXIDA EN MEDIO ALCALINO, DESACETILA Y CICLISA. SE BLOQUEA LA FUNCION ALCOHOL DEL PRODUCTO OBTENIDO EN FORMA DE ETER Y TRATA CON HALURO DE ALCOHILO, ALQUENILO O ALUINILO EN MEDIO BASICO. SE HIDROLIZA Y OXIDA. SE HALOGENA EN POSICION 21 Y ACETOXILA Y, EVENTUALMENTE, SAPONIFICA. SE TRATA CON UN ACIDO, UN DERIVADO FUNCIONAL DE ACIDO QUE CONTIENE DE 1 A 20 ATOMOS DE CARBONO, O UN DERIVADO FUNCIONAL DEL ACIDO FOSFORICO. ESTOS COMPUESTOS TIENEN APLICACION FARMACOLOGICA EN EL TRATAMIENTO DE LA HIPERTENSION ARTERIAL Y LAS INSUFICIENCIAS CARDIACAS. *FORMULA* L
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7835046A FR2444047A1 (fr) | 1978-12-13 | 1978-12-13 | Nouveaux derives 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8102149A1 true ES8102149A1 (es) | 1980-12-16 |
ES486791A0 ES486791A0 (es) | 1980-12-16 |
Family
ID=9216044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES486791A Granted ES486791A0 (es) | 1978-12-13 | 1979-12-12 | Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4263290A (es) |
EP (2) | EP0044575B1 (es) |
JP (1) | JPS5585598A (es) |
AU (1) | AU527582B2 (es) |
CA (1) | CA1146531A (es) |
DK (1) | DK527379A (es) |
ES (1) | ES486791A0 (es) |
FI (1) | FI70027C (es) |
FR (1) | FR2444047A1 (es) |
HU (1) | HU180931B (es) |
IE (1) | IE49235B1 (es) |
PT (1) | PT70575A (es) |
SU (1) | SU1178325A3 (es) |
ZA (1) | ZA796194B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3229993A (en) * | 1992-11-30 | 1994-06-22 | Mallinckrodt Medical, Inc. | Steroid-21-phosphate complex of technetium-99m |
US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
FR2917975B1 (fr) * | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
US20090270356A1 (en) * | 2008-04-28 | 2009-10-29 | Ceva Sante Animale Sa | Compositions and treatments of heart failure in non-human mammal animals |
EP2632471B1 (en) | 2010-10-27 | 2019-05-01 | Dignity Health | Trimegestone (tmg) for treatment of preterm birth |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138460A (en) * | 1965-06-01 | 1969-01-01 | Merck & Co Inc | Steroid compounds |
FR1476572A (fr) * | 1965-09-13 | 1967-04-14 | Gonènes synthétiques et leur procédé de préparation | |
FR2322606A1 (fr) * | 1975-09-02 | 1977-04-01 | Roussel Uclaf | Nouveaux 2,2-dimethyl steroides, leur procede de preparation et leur application comme medicament |
FR2364655A1 (fr) * | 1976-09-17 | 1978-04-14 | Roussel Uclaf | Nouveaux 2,2-dimethyl 19-nor steroides, leur procede de preparation et leur application comme medicament |
-
1978
- 1978-12-13 FR FR7835046A patent/FR2444047A1/fr active Granted
-
1979
- 1979-11-14 EP EP81200353A patent/EP0044575B1/fr not_active Expired
- 1979-11-14 EP EP79400873A patent/EP0012641B1/fr not_active Expired
- 1979-11-16 ZA ZA00796194A patent/ZA796194B/xx unknown
- 1979-11-23 HU HU79RO1045A patent/HU180931B/hu not_active IP Right Cessation
- 1979-11-30 US US06/098,766 patent/US4263290A/en not_active Expired - Lifetime
- 1979-12-10 SU SU792850118A patent/SU1178325A3/ru active
- 1979-12-10 FI FI793847A patent/FI70027C/fi not_active IP Right Cessation
- 1979-12-11 PT PT70575A patent/PT70575A/pt unknown
- 1979-12-12 ES ES486791A patent/ES486791A0/es active Granted
- 1979-12-12 CA CA000341751A patent/CA1146531A/fr not_active Expired
- 1979-12-12 AU AU53762/79A patent/AU527582B2/en not_active Ceased
- 1979-12-12 DK DK527379A patent/DK527379A/da not_active Application Discontinuation
- 1979-12-13 JP JP16090879A patent/JPS5585598A/ja active Granted
- 1979-12-13 IE IE2420/79A patent/IE49235B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE792420L (en) | 1980-06-13 |
HU180931B (en) | 1983-05-30 |
DK527379A (da) | 1980-06-14 |
JPS5585598A (en) | 1980-06-27 |
FI793847A (fi) | 1980-06-14 |
FR2444047A1 (fr) | 1980-07-11 |
EP0012641A3 (en) | 1980-09-17 |
FI70027B (fi) | 1986-01-31 |
PT70575A (fr) | 1980-01-01 |
IE49235B1 (en) | 1985-09-04 |
EP0012641B1 (fr) | 1982-05-12 |
EP0044575B1 (fr) | 1984-03-21 |
SU1178325A3 (ru) | 1985-09-07 |
FI70027C (fi) | 1986-09-12 |
FR2444047B1 (es) | 1982-05-28 |
ZA796194B (en) | 1980-11-26 |
AU5376279A (en) | 1980-07-10 |
AU527582B2 (en) | 1983-03-10 |
EP0012641A2 (fr) | 1980-06-25 |
CA1146531A (fr) | 1983-05-17 |
US4263290A (en) | 1981-04-21 |
JPS6337796B2 (es) | 1988-07-27 |
EP0044575A1 (fr) | 1982-01-27 |
ES486791A0 (es) | 1980-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE780078L (en) | 11-beta substituted steroids | |
ES8104321A1 (es) | Procedimiento para separar un derivado de alquil-cetohexopi-ranosida | |
ES482918A1 (es) | Procedimiento para la preparacion de derivados de indanilo | |
AU527592B2 (en) | 3,20-dioxo-4,9-diene-21-hydroxyl steroid derivatives | |
ES8200108A1 (es) | Un procedimiento para la preparacion de derivados de tioxan tina. | |
ES8206509A1 (es) | Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivos | |
GB1095894A (en) | Substituted indolizines and preparation thereof | |
ES8102149A1 (es) | Un procedimiento de preparacion de nuevos 19-nor-esteroides sustituidos en posicion 2 | |
SE7613990L (sv) | Orasyraderivat sett att framstella nya7-amino-t iazolyl-acetamido-cefalosp | |
IE781753L (en) | Steroid 3-oximes | |
ES8101592A1 (es) | Un procedimiento para la preparacion del acido 7-oxo-1-aza- biciclo (3.2.0)hept-2-en-2-carboxilico | |
JPS5559127A (en) | Novel intermediate compound for producing prostanoids and its manufacture | |
ZA801614B (en) | New 7-alkyl steroid derivatives,process for their preparation,their use as medicaments and the pharmaceutical compositions containing them | |
JPS57126435A (en) | Novel derivatives of cyclopentanol, manufacture, use as perfume and composition and novel intermediate product containing same | |
SE7711105L (sv) | Sett att framstella nya 17-spirosultinderivat och motsvarande gamma-hydroxisyror | |
ES471267A1 (es) | Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos | |
HUT34995A (en) | Process for producing 7-alpha-substituted-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone derivatives and pharmaceutical compositions containing them as active agents | |
DE3161634D1 (en) | Alkyl-4-methyl-3-formyl pentenoates, their preparation, their use in the preparation of the 4-methyl-3-formyl-3-pentenoic acid and the intermediates | |
ES8102110A1 (es) | Procedimiento para la preparacion de acido 1,2,3-tiadiazol- 5-il-tioglicolico | |
ES473646A1 (es) | Un procedimiento para la preparacion de nuevos esteroides dela serie del pregnano | |
ES469513A1 (es) | Procedimiento para preparar nuevos derivados de pregn-4-eno. | |
DE3068274D1 (en) | Corticoid-17-thioacetals, their preparation and use | |
ES8405033A1 (es) | Procedimiento para la obtencion de esteroides dihalogenados. | |
ES485973A1 (es) | Un procedimiento de preparacion de nuevos derivados de amino-3-sulfamido-6-(1h,3h)-quinazolin-dionas-2,4 | |
ES8106281A1 (es) | Procedimiento para la obtencion de derivados de los acidos aminosulfonicos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |