KR840007419A - 1H,3H-피롤로[1,2-c]티아졸유도체의제조방법 - Google Patents
1H,3H-피롤로[1,2-c]티아졸유도체의제조방법 Download PDFInfo
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- KR840007419A KR840007419A KR1019840000095A KR840000095A KR840007419A KR 840007419 A KR840007419 A KR 840007419A KR 1019840000095 A KR1019840000095 A KR 1019840000095A KR 840000095 A KR840000095 A KR 840000095A KR 840007419 A KR840007419 A KR 840007419A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 2-클로로아크릴로니트릴을 하기 구조식(A)의 화합물과 반응시켜 R이 시아노라이디칼을 나타내며 R1과 R2가 하기 정의한 바와 같은 하기 일반식(I)의 화합물을 생성하거나; N, N′-카보닐이미다졸을 하기 구조식(B)의 산과 반응시켜 R1과 R2가 하기 정의한 바와 같으며 R이의 라디칼(여기서 R3와 R4는 그들이 결합되어 있는 질소원자와 함께 이미다졸릴환을 형성한다)을 나타내는 화합물을 생성하거나; 암모니아 또는 하기 구조식(C)의 화합물을 하기 구조식(D)의 산과 반응시켜 R1과 R2가 하기 정의한 바와 같으며, R이의 라디칼(여기서 R3와 R4는R3와 R4가 그들이 결합되어 있는 질소원자와 함께 이미다졸릴환을 형성하지 않는 경우를 제외하곤 하기 b)에서 정의한 바와 같다)을 나타내는 화합물을 생성하거나; 하기 구조식(E)의 니트릴을 가수분해하여 R1과 R2가 하기 정의한 바와 같으며, R이의 라디칼(여기서, R3와 R4는 각기 수소원자를 나타낸다)을 나타내는 화합물을 생성하거나; 2-클로로아크릴아미드를 하기 구조식(F)의 산과 반응시켜 R1과 R2가 하기 정의한 바와 같으며 R이의 라디탈(여기서 R3과 R4는 각기 수소원자를 나타낸다)을 나타내는 화합물을 생성하거나; 에틸말로네이트의 에톡시마그그네슘유도체를 하기 구조식(G)의 화합물과 반응시킨 다음 얻어진 생성물을 가수분해하고 탈가복실화하여 R1과 R2가 하기 정의한 바와 같으며 R이 아세틸라디칼을 나타내는 화합물을 생성하거나; 하기 구조식(H)의 유기 마그네슘 유도체를 하기 구조식(I)의 니트릴과 반응시킨 다음 얻어진 생성물을 가수분해하여 R1과 R1가 하기 정의한 바와 같으며 R이 알킬카보닐라디칼을 나타내는 화합물을 생성하거나; 하기 구조식(J)의 하이드라진을 하기 구조식(K)의 화합물과 반응시켜 R1과 R2가 하기 정의한 바와 같으며 R이 하기 구조의 라디칼을 나타내는 화합물을 생성하거나 한다음;얻어진 생성물을 단리하고 적합한 경우 이를 산과의 부가염이나 금속염 또는 질소염기와의 부가염으로 전환시키는 것으로 구성된, 하기 일반식 (I)의 1H,3H-피롤로[1,2-c]티아졸유도체 및 산과의 부가염, 이들이 존재하는 경우 금속염 및 질소염기와의 부가염을 제조하는 방법.상기 식에서, R1과 R2는 동일 또는 상이한 것으로 수소원자 또는 알킬라디칼을 나타내며, a) R은 시아노 또는 알킬카보닐라디칼을 나타내거나; b) R은 일반식(II)의 라디칼을 나타내거나;(여기서, R3는 수소원자, R3는 아미노, 알킬아미노, 디알킬아미노, 페닐아미노 또는 디페닐아미노라디칼을 나타내거나 또는 R3과 R4는 동일 또는 상이한 것으로 수소원자나 C1-5의 알킬라디칼이나 치환된 페닐라디칼을 나타내거나 또는 R3는 수소원자, R4는 피리딜라디칼 또는 C1-5알킬라디칼을 나타내거나〔이것은 카복실, 아미노, 알킬아미노, 디알킬아미노, 몰폴리노, 피페리디노, 피롤리딘-1-일라디칼, 피페라진-1-일 라디칼(비치환되었거나 4-위치가 알킬라디칼, 피리딜라디칼, 비치환되거나 치환된 페닐라디칼 또는 비치환되거나 치환된 벤질라디칼에 의해 치환되었음), 비치환되거나 치환된 페닐라디칼, 피리딜 또는 이미다졸릴 라디칼에 의해 치환되었음〕또와 R3와 R4는 이들이 결합되어 있는 질소원자와 함께 이미다졸릴라디칼이나 5원소 또는 6-원소헤테로고리를 형성하며 이것은 산소, 유황, 질소 같은 또 다른 질소원자를 함유할 수 있으며, 비치환되었거나 또는 알킬, 알콕시카보닐, 하이드록시알킬, 아미노알킬, 알킬아미노알킬, 디알킬아미노알킬, 피리딜, 피리미디닐, 또는 피라지닐라디칼이나 비치환되거나 치환된 벤질라디칼에 의해 치환되었음) 또는 c) R은 하기 구조(III) 또는 (IV)의 라디칼을 나타내며(여기서 R′와 R″는 동일 또는 상이한 것으로 알킬라디칼을 나타낸다) 알킬라디칼과 상기 언급한 라디칼의 알킬부분은 직쇄 또는 분지쇄로서 따로 언급하지 않는 한 1-4개의 탄소원자를 함유하며 상기 페닐 및 벤질기상의 치환분으로는 할로겐, 알킬, 알콕시, 알킬티오, 트리플루오로메틸 또는 디알킬아미노라디칼이 가능하며, R이 구조식(III) 또는 (IV)의 라디칼을 나타내는 경우 구조식(I)의 화합물의 호변 이성체가 포함된다.상기 식들에서, R1,R2·R′,R″는 상기 정의한 바와 같으며 R3와 R4는 그들이 결합되어 있는 질소원자와 함께 이미다졸릴환을 형성하지 않는 경우를 제외하곤 상기 b)에서 정의한 바와 같으며, Y는 할로겐원자를 나타내며, R′″는 알킬라디칼을 나타내며, X는 할로겐원자를 나타내며, Ro는 알킬라디칼을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8300453 | 1983-01-13 | ||
FR8300453A FR2541280B1 (fr) | 1983-01-13 | 1983-01-13 | Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840007419A true KR840007419A (ko) | 1984-12-07 |
KR910001482B1 KR910001482B1 (ko) | 1991-03-09 |
Family
ID=9284898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8400095A KR910001482B1 (ko) | 1983-01-13 | 1984-01-12 | 1H, 3H-피롤로 [1,2-c] 티아졸유도체의 제조방법 |
Country Status (28)
Country | Link |
---|---|
US (1) | US4529728A (ko) |
EP (1) | EP0115979B1 (ko) |
JP (2) | JPS59137490A (ko) |
KR (1) | KR910001482B1 (ko) |
AR (1) | AR240828A1 (ko) |
AT (1) | ATE21248T1 (ko) |
AU (1) | AU562795B2 (ko) |
BG (2) | BG40145A3 (ko) |
CA (1) | CA1229603A (ko) |
CS (1) | CS262417B2 (ko) |
DD (1) | DD218362A5 (ko) |
DE (1) | DE3460401D1 (ko) |
DK (1) | DK13984A (ko) |
ES (2) | ES528873A0 (ko) |
FI (1) | FI76577C (ko) |
FR (1) | FR2541280B1 (ko) |
GR (1) | GR81679B (ko) |
HU (1) | HU193277B (ko) |
IE (1) | IE56839B1 (ko) |
IL (1) | IL70664A (ko) |
MA (1) | MA20001A1 (ko) |
MX (5) | MX160610A (ko) |
NO (1) | NO167031C (ko) |
NZ (1) | NZ206807A (ko) |
PL (2) | PL141846B1 (ko) |
PT (1) | PT77952B (ko) |
SU (3) | SU1245263A3 (ko) |
ZA (2) | ZA84233B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2557111B1 (fr) * | 1983-12-21 | 1986-04-11 | Rhone Poulenc Sante | Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent |
FR2601016B1 (fr) * | 1986-07-04 | 1988-10-07 | Rhone Poulenc Sante | Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2601015B1 (fr) * | 1986-07-04 | 1988-08-05 | Rhone Poulenc Sante | Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent |
CN1030415A (zh) | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
FR2617484B1 (fr) * | 1987-07-02 | 1989-10-20 | Rhone Poulenc Sante | Procede de preparation de l'acide (pyridyl-3)-3 1h-3h-pyrrolo (1,2-c) thiazolecarboxylique-7 dextrogyre |
FR2626004B1 (fr) * | 1988-01-20 | 1991-08-02 | Rhone Poulenc Sante | Procede de preparation du (pyridyl-3)-3 1h, 3h-pyrrolo (1,2-c) thiazolecarbonitrile-7 |
FR2644456B1 (fr) * | 1989-03-17 | 1991-07-05 | Rhone Poulenc Sante | Nouveaux derives du 1h, 3h-pyrrolo(1,2-c)thiazolecarboxamide-7, leur preparation et les compositions pharmaceutiques qui les contiennent |
AU5938390A (en) * | 1989-06-26 | 1991-01-17 | Research Foundation Of The State University Of New York, The | Bis-acyloxymethyl derivatives |
FR2678834A1 (fr) * | 1991-07-09 | 1993-01-15 | Rhone Poulenc Rorer Sa | Nouvelle application therapeutique du pyridylpyrrolothiazole carboxamide. |
ES2131530T3 (es) * | 1991-07-17 | 1999-08-01 | Abbott Lab | Antagonistas del factor de activacion de las plaquetas. |
HU230518B1 (hu) * | 2005-12-20 | 2016-10-28 | Richter Gedeon Nyrt. | Bradykinin B1 receptor szelektív antagonista hatással rendelkező új fenatridin származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3544590A (en) * | 1967-04-28 | 1970-12-01 | Exxon Research Engineering Co | Cyclic amines and the process for their formation |
US3865839A (en) * | 1973-03-01 | 1975-02-11 | Hoechst Co American | Thiopyranopyrrolylsalicyclic acids and derivatives thereof |
-
1983
- 1983-01-13 FR FR8300453A patent/FR2541280B1/fr not_active Expired
-
1984
- 1984-01-10 BG BG8465204A patent/BG40145A3/xx unknown
- 1984-01-10 CS CS84197A patent/CS262417B2/cs unknown
- 1984-01-10 BG BG8465203A patent/BG40144A3/xx unknown
- 1984-01-11 ZA ZA84233A patent/ZA84233B/xx unknown
- 1984-01-11 AU AU23202/84A patent/AU562795B2/en not_active Ceased
- 1984-01-11 US US06/569,908 patent/US4529728A/en not_active Expired - Fee Related
- 1984-01-11 DD DD84259351A patent/DD218362A5/de not_active IP Right Cessation
- 1984-01-11 ZA ZA84235A patent/ZA84235B/xx unknown
- 1984-01-11 IL IL70664A patent/IL70664A/xx unknown
- 1984-01-11 MA MA20222A patent/MA20001A1/fr unknown
- 1984-01-11 NZ NZ206807A patent/NZ206807A/en unknown
- 1984-01-11 GR GR73491A patent/GR81679B/el unknown
- 1984-01-12 IE IE64/84A patent/IE56839B1/en not_active IP Right Cessation
- 1984-01-12 EP EP84400057A patent/EP0115979B1/fr not_active Expired
- 1984-01-12 CA CA000445146A patent/CA1229603A/fr not_active Expired
- 1984-01-12 AT AT84400057T patent/ATE21248T1/de not_active IP Right Cessation
- 1984-01-12 MX MX6146A patent/MX160610A/es unknown
- 1984-01-12 KR KR8400095A patent/KR910001482B1/ko not_active IP Right Cessation
- 1984-01-12 NO NO840106A patent/NO167031C/no unknown
- 1984-01-12 FI FI840106A patent/FI76577C/fi not_active IP Right Cessation
- 1984-01-12 DE DE8484400057T patent/DE3460401D1/de not_active Expired
- 1984-01-12 HU HU8480A patent/HU193277B/hu unknown
- 1984-01-12 SU SU843692013A patent/SU1245263A3/ru active
- 1984-01-12 DK DK13984A patent/DK13984A/da not_active Application Discontinuation
- 1984-01-12 PT PT77952A patent/PT77952B/pt not_active IP Right Cessation
- 1984-01-13 JP JP59003687A patent/JPS59137490A/ja active Granted
- 1984-01-13 ES ES528873A patent/ES528873A0/es active Granted
- 1984-01-13 AR AR295414A patent/AR240828A1/es active
- 1984-01-13 JP JP59003686A patent/JPH0653748B2/ja not_active Expired - Lifetime
- 1984-01-13 PL PL1984245701A patent/PL141846B1/pl unknown
- 1984-01-13 PL PL1984251304A patent/PL140595B1/pl unknown
- 1984-04-11 ES ES531518A patent/ES8502123A1/es not_active Expired
- 1984-10-17 SU SU843799806A patent/SU1284459A3/ru active
- 1984-10-17 SU SU843801005A patent/SU1266472A3/ru active
-
1988
- 1988-10-05 MX MX1329188A patent/MX13291A/es unknown
- 1988-10-05 MX MX1329288A patent/MX13292A/es unknown
- 1988-10-18 MX MX1346288A patent/MX13462A/es unknown
- 1988-10-18 MX MX1346388A patent/MX13463A/es unknown
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