KR840006674A - 디디히드로 밀베마이신 유도체의 제조방법 - Google Patents

디디히드로 밀베마이신 유도체의 제조방법 Download PDF

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KR840006674A
KR840006674A KR1019830005571A KR830005571A KR840006674A KR 840006674 A KR840006674 A KR 840006674A KR 1019830005571 A KR1019830005571 A KR 1019830005571A KR 830005571 A KR830005571 A KR 830005571A KR 840006674 A KR840006674 A KR 840006674A
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KR880001868B1 (ko
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데준 야 이 (외 3)
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가와무라 요시부미
상꾜 가부시기 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

디디히드로 밀베마이신 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(Ⅲ)의 화합물을 하기 일반식(Ⅳ)의 옥심화제 또는 그의 염과 반응시키고, 생성된 일반식(Ⅱ)의 화합물(R2가 수소원자임)을 산할라이드 또는 이소시아네이트와 임의로 반응시켜 화합물(Ⅱ)의 에스테르를 제조함을 특징으로 하는 하기 일반식(Ⅱ)의 화합물 및 그의 염 및 에스테르의 제조방법.
  5. 상기 식중, R1은 메틸기, 에틸기 또는 이소프로필기 이고, R2는 수소원자, C1-C6알킬기, 하나 이상의 C1-C6알킬, 할로겐 또는 니트로 치환제를 임의로 갖는 아르알킬기, 또는 일반식 -CH2COOR3의 기(R3는 수소원자 또는 C1-C6알킬기를 나타낸다)이며, R2는 수소원자를 나타낸다.
  6. 제1항에 있어서, 일반식(Ⅲ)의 화합물을 일반식(Ⅳ)의 옥심화제 또는 그의 염과 반응시킴을 특징으로 하는 일반식(Ⅱ)의 화합물(R2는 수소, C1-C6알킬기, 벤질 또는 카르복시 메틸기를 나타낸다)의 제조방법.
  7. 제1항에 있어서, 일반식(Ⅲ)의 화합물을 히드록시아민 또는 그의 염과 반응시키고, 생성된 일반식(Ⅱ)의 화합물(R2는 수소위자를 나타냄)을 일반식 R2a-X(R2a는 하기와 같고, X는 할로겐 원자이다)의 산할라이드와 반응시킴을 특징으로 하는 하기 일반식(Ⅱa)의 화합물의 제조방법.
  9. 상기식중, R1은 메틸, 에틸 또는 이소프로필기를 나타내고, R2a는, 일반식 -COR4의 기(식중 R4는 C1-C6알킬기, 하나 이상의 C1-C6알킬, 할로겐 또는 니트로 치환체를 임의로 갖는 아르알킬기, 하나이상의 C1-C6알킬, 할로겐, 니트로, 카르복시 또는 C2-C7알콕시 카르보닐 치환제를 임의로 갖는 폐닐기, 또는 일반식 -(CH2)nCOOR5의 기(n은 1∼3의 정수이고, R5는 수소원자 또는 C1-C6알킬기이다)를 나타낸다); 일반식 -CONR6'R7'의 기(식중 R6'는 C1-C6알킬기를 나타내고,'R7'는 C1-C6알킬기, 아릴기 또는 일반식 -CH(R8)COOR9의 기(식중 R8및 R9는 같거나 서로 다르고, 각각 수소 또는 C1-C6알킬기이다)를 나타낸다); 일반식 -COOR10의 기(식중 R10은 C1-C6알킬기, 하나 이상의 C1-C6알킬, 할로겐 또는 니트로 치환제를 임의로 갖는 아르알킬기, 아릴기 또는 임의 보호된 슈가 알콜로부터 오메가 히드록시기를 제거함으로써 유도된 기를 나타낸다); 일반식 -SO2R11의 기 (식중 R10은 C1-C6알킬기 또는 아릴기를 나타낸다); 또는 일반식 -(Y1=)P(-Y2-R13)2의 기(식중 Y1및 Y2는 같거나 서로 다르고, 각각 산소 또는 황을 나타내며, Y2로 표시된 두 원자는 같거나 서로 다르고, R12로 표시된 각기는 같거나 서로 다르며 C1-C6알킬기를 나타낸다)를 나타낸다.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005571A 1982-11-25 1983-11-24 디데히드로 밀베마이신 유도체의 제조방법 KR880001868B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP206462/1982 1982-11-25
JP206462 1982-11-25
JP57206462A JPS59108785A (ja) 1982-11-25 1982-11-25 ミルベマイシン類の５−オキシム誘導体

Publications (2)

Publication Number Publication Date
KR840006674A true KR840006674A (ko) 1984-12-01
KR880001868B1 KR880001868B1 (ko) 1988-09-23

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Country Status (12)

Country Link
US (1) US4547520A (ko)
EP (1) EP0110667B1 (ko)
JP (1) JPS59108785A (ko)
KR (1) KR880001868B1 (ko)
AR (1) AR240048A1 (ko)
BR (1) BR8306467A (ko)
CA (1) CA1215360A (ko)
DE (1) DE3369517D1 (ko)
IE (1) IE56309B1 (ko)
IL (1) IL70301A (ko)
NZ (1) NZ206399A (ko)
ZA (1) ZA838761B (ko)

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Also Published As

Publication number Publication date
JPS59108785A (ja) 1984-06-23
KR880001868B1 (ko) 1988-09-23
IE832762L (en) 1984-05-25
EP0110667B1 (en) 1987-01-28
ZA838761B (en) 1984-08-29
IL70301A0 (en) 1984-02-29
US4547520A (en) 1985-10-15
NZ206399A (en) 1986-02-21
AR240048A1 (es) 1990-01-31
DE3369517D1 (en) 1987-03-05
BR8306467A (pt) 1984-06-26
EP0110667A1 (en) 1984-06-13
IE56309B1 (en) 1991-06-19
CA1215360A (en) 1986-12-16
IL70301A (en) 1987-09-16

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