KR840006129A - 성인 t세포 백혈병 연관항원의 제조방법 - Google Patents
성인 t세포 백혈병 연관항원의 제조방법 Download PDFInfo
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- KR840006129A KR840006129A KR1019830004655A KR830004655A KR840006129A KR 840006129 A KR840006129 A KR 840006129A KR 1019830004655 A KR1019830004655 A KR 1019830004655A KR 830004655 A KR830004655 A KR 830004655A KR 840006129 A KR840006129 A KR 840006129A
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- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 title claims 33
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 title claims 33
- 201000006966 adult T-cell leukemia Diseases 0.000 title claims 33
- 102000036639 antigens Human genes 0.000 title claims 27
- 108091007433 antigens Proteins 0.000 title claims 27
- 239000000427 antigen Substances 0.000 title claims 26
- 238000002360 preparation method Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims description 19
- 238000003018 immunoassay Methods 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims 26
- 239000004094 surface-active agent Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 210000002966 serum Anatomy 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- ZPIRTVJRHUMMOI-UHFFFAOYSA-N octoxybenzene Chemical compound CCCCCCCCOC1=CC=CC=C1 ZPIRTVJRHUMMOI-UHFFFAOYSA-N 0.000 claims 5
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims 4
- 229960003964 deoxycholic acid Drugs 0.000 claims 4
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 claims 4
- 239000012736 aqueous medium Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000035931 haemagglutination Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Y10S435/00—Chemistry: molecular biology and microbiology
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 간접형광체법에 의하여 측정된 형광항체 역가와 본 발명에 따르는(시험실시예 2에 따라서 얻은 결과를 기본으로 하여)효소면역 측정법에 의하여 측정된 OD450 값과의 관계를 나타내는 그라프이다.
Claims (23)
- 성인 T세포 백혈병 연관항원 생성세포를, 이 세포로부터 상기 항원을 분리시킬수 있는 계면활성제로 처리하는 단계와, 다음에 상기 항원을 회수하는 단계를 포함하는 것을 특징으로 하는, 성인 T세포 백혈병연관항원의 제조방법.
- 제1항에 있어서, 상기 계면활성제가 나트륨 데옥시콜레이트, 옥틸페녹시폴리에톡시에타놀 및 폴리옥시에틸렌(10)옥틸페닐 에테르로 구성되는 군으로부터 선택되는 것을 특징으로 하는, 성인 T세포 백혈병연관항원의 제조방법.
- 제1항에 있어서, 상기 성인 T세포 백혈병연관항원 생성세포가 MT-2세포인 것을 특징으로 하는, 성인 T세포 백혈병 연관항원의 제조방법.
- 제2항에 있어서, 상기성인 T세포 백혈병 연관항원 생성세포가 MT-2세포인 것을 특징으로 하는 성인 T세포 백혈병 연관항원의 제조방법.
- 성인 T세포 백혈병연관 항원단백과 성인 T세포 백혈병연관 C형 바이러스입자로 구성되는 성인 T세포 백혈병연관항원을 생성케하는 세포를 제공하는 단계와:나트륨 데옥시콜레이터, 옥틸페녹시폴리에톡시에타놀 및 폴리옥시에틸렌(10)옥틸페닐에테르로 구성되는 군으로부터 선택된 계면활성제를 수성매제내의 상기 세포에 가하여 혼합물을 형성시키는 단계와:상기 혼합물로부터 상기 항원을 분리하는 단계:로 구성되는 것을 특징으로 하는 성인 T세포 백혈병 연관항원의 제조방법.
- 제5항에 있어서, 상기 성인 T세포 백혈병 연관항원 생성세포가 MT-2세포인 것을 특징으로 하는 성인 T세포 백혈병 연관항원의 제조방법.
- 제6항에 있어서, 성인 T세포 백혈병 여환자의 백혈병세포를 영양 배양기(培養基)내에서 정상의 비백혈병 신생남아의 제대적혈구와 함께 배양시켜서 상기의 MT-2세포를 형성시키는 단계를 더 포함하는 것을 특징으로 하는 성인 T세포 백혈병 연관항원의 제조방법.
- 제5항에 있어서, 상기 계면활성제를 제거하기 전에 상기 혼합물을 교반하는 단계와, 다음에 상기 혼합물로부터 상기 계면활성제를 제거하기 위하여 상기 혼합물을 투석시키는 단계와, 다음에 상기 혼합물을 원심분리하여 상기 항원을 함유하는 상등액을 얻는 단계를 더 포함하는 것을 특징으로 하는, 성인 T세포 백혈병 연관항원의 제조방법.
- 제8항에 있어서, 상기 수성매제가 인산염-완충식염수용액인 것을 특징으로 하는, 성인 T세포 백혈병 연관항원의 제조방법.
- 성인 T세포 백혈병연관항원 생성세포를 이 세포로부터 상기 항원을 분리할 수 있는 계면활성제로 처리하고 이로부터 상기 항원을 회수함으로써 얻은 성인 T세포 백혈병 연관항원으로 사람으로부터 유도해낸 혈청시료를 분석하고, 이에 의하여 성인 T세포 백혈병 연관항체가 상기 혈청시료내에 존재하는 지의 여부를 결정함으로써 계량된 것을 특징으로 하는 면역 측정에 의한 성인 T세포 백혈병 연관항체의 측정방법.
- 제10항에 있어서, 상기 계면활성제가 나트륨 데옥시콜레이트, 옥틸페녹시폴리에톡시에타놀 또는 폴리옥시에틸렌(10)옥틸 페닐에테르로 구성되는 군으로부터 선택되는 것을 특징으로 하는, 성인 세포 백혈병연관항체의 측정방법.
- 제10항에 있어서, 상기 성인 T세포 백혈병 연관항원 생성세포가 MT-2세포인 것을 특징으로 하는 성인 T세포 백혈병 연관항체의 측정방법.
- 성인 세포 백혈병연관항원 단백과 성인 T세포 백혈병연관 C형 바이러스입자로 구성되는 성인 T세포 백혈병연관항원 생성세포를 제공하는 단계와:나트륨 데옥시콜레이트, 옥틸페녹시폴리에톡시에타놀 및 폴리옥시 에틸렌(10)옥틸페닐에테르로 구성되는 군으로부터 선택된 계면활성제를 수성매제내의 상기 세포에 가하여 혼합물을 형성하는 단계와 : 상기 혼합물로부터 상기 항원을 분리하는 단계와:사람으로부터 유도해낸 혈청시료를 상기 성인 T세포 백혈병연관항원으로 면역측정하여 상기 혈청시료에 존재하는 성인 T세포 백혈병연관항체의 함량을 측정하는 단계:로 구성되는 것을 특징으로 하는, 성인 T세포 백혈병 연관항체의 측정방법.
- 제13항에 있어서, 상기 혈청시료를 면역측정하는 단계가 효소면역측정법에 의하여 수행되는 것을 특징으로 하는, 성인 T세포 백혈병 연관항체의 측정방법.
- 제13항에 있어서, 상기 혈청시료를 면역측정하는 단계가 방사면역측정에 의하여 수행하는 것을 특징으로 하는 , 성인 T세포 백혈병 연관항체의 측정방법.
- 제13항에 있어서, 상기 혈청시료를 면역측정하는 단계가 수신 혈구응집법에 의하여 수행되는 것을 특징으로 하는, 성인 T세포 백혈병 연관항체의 측정방법.
- 제13항에 있어서 상기 세포가 MT-2세포인 것을 특징으로 하는, 성인 T세포 백혈병 연관항체의 측정방법.
- 제14항에 있어서, 상기 혈청시료에 상기 항원을 가해주는 단계와 :상기 시료에 효소-표지 항-인간IgG항체를 가해주는 단계와:다음에 상기 시료를 배양하는 단계와:다음에 상기 효소에 의하여 분해 될 수 있는 기질을 상기 시료에 가하는 단계와 :다음에 상기 시료를 더 배양하는 단계와:다음에 상기 시료내의 분해된 기질의 양을 측정하는 단계와:분해된 상기 기질의 상기 양을 기준으로 상기 시료에 존재하는 성인 T세포 백혈병 항체의 양을 측정하는 단계:에 의하여 상기 효소면역측정을 수행하는 과정을 더 포함하는 것을 특징으로 하는 성인 T세포 백혈병 연관항체의 측정방법.
- 청구범위 1항의 방법에 의하여 얻어진 성인 T세포 백혈병연관 항원을 함유하는 것을 특징으로 하는, 면역측정에 의한 성인 T세포 백혈병 연관항체 측정에 사용하기 적합한 시약.
- 제19항에 있어서, 상기 계면활성제가 나트륨 데옥시콜레이트, 옥틸페녹시폴리에톡시에타놀 및 폴리옥시에틸렌(10)옥틸페닐 에테르로 구성돠는 군으로부터 선택되는 것을 특징으로 하는 성인 T세포 백혈병연관항체 측정용 시약.
- 제19항에 있어서, 상기 세포가 MT-2세포인 것을 특징으로 하는 성인 T세포 백혈병 연관항체 측정용 시약.
- 제20항에 있어서, 상기 세포가 MT-2세포인 것을 특징으로 하는 성인 T세포 백혈병 연관항체 측정용 시약.
- 청구범위 5항의 방법으로 얻어진 성인 T세포 백혈병연관항원을 함유하는 것을 특징으로 하는, 면역측정에 의한 성인 T세포 백혈병연관항체 측정에 사용하기 적합한 시약.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57169670A JPS5962527A (ja) | 1982-09-30 | 1982-09-30 | 成人ｔ細胞白血病関連抗原の製造方法 |
| JP57-169670 | 1982-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840006129A true KR840006129A (ko) | 1984-11-22 |
| KR880001809B1 KR880001809B1 (ko) | 1988-09-19 |
Family
ID=15890732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004655A KR880001809B1 (ko) | 1982-09-30 | 1983-09-30 | 성인 t 세포 백혈병 연관항원의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4588681A (ko) |
| EP (1) | EP0105465B1 (ko) |
| JP (1) | JPS5962527A (ko) |
| KR (1) | KR880001809B1 (ko) |
| AT (1) | ATE59963T1 (ko) |
| DE (1) | DE3382121D1 (ko) |
| PH (1) | PH19320A (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59151885A (ja) * | 1983-02-18 | 1984-08-30 | Eisai Co Ltd | 成人ｔ細胞白血病関連細胞株 |
| US4743678A (en) * | 1983-04-27 | 1988-05-10 | President And Fellows Of Harvard College | Method and products for detection of human T cell leukemia virus |
| JPS6044870A (ja) * | 1983-08-22 | 1985-03-11 | Fujirebio Inc | 成人ｔ細胞白血病ウイルス抗体検出用試薬 |
| JPS6061534A (ja) * | 1983-09-16 | 1985-04-09 | Kyowa Hakko Kogyo Co Ltd | 成人ｔ細胞白血病ウイルス抗原ペプチド |
| JPS60249058A (ja) * | 1984-05-25 | 1985-12-09 | Eisai Co Ltd | Ａｔｌウイルス抗体の測定方法および試薬 |
| US5510238A (en) * | 1984-10-26 | 1996-04-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Production of human T-cell leukemia (lymphotropic) retrovirus (HTLV-I) envelope protein fragments in bacteria and use in seroepidemiological studies |
| US4722888A (en) * | 1985-03-29 | 1988-02-02 | United States Of America As Represented By The Department Of Health And Human Services | Cell line producing human monoclonal antibody which binds to HTLV-I producing cells |
| US4814269A (en) * | 1985-03-29 | 1989-03-21 | Cenfold Holdings S.A. | Diagnostic testing for antibodies against microorganisms |
| AT383424B (de) * | 1985-08-13 | 1987-07-10 | Waldheim Pharmazeutika Gmbh | Verfahren zum nachweis von antikoerpern und verfahren zur herstellung eines mittels zum nachweis von antikoerpern |
| JP2564268B2 (ja) * | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
| US5364933A (en) | 1986-03-03 | 1994-11-15 | Institut Pasteur | Methods of immunopurification of antigens of human immunodeficiency virus type 2 (HIV-2) |
| US6514691B1 (en) * | 1986-01-22 | 2003-02-04 | Institut Pasteur | Peptides of human immunodeficiency virus type 2 (HIV-2), antibodies against peptides of HIV-2, and methods and kits for detecting HIV-2 |
| JPS62182662A (ja) * | 1986-02-06 | 1987-08-11 | Fujirebio Inc | ウイルス抗体検出用試薬 |
| US5614366A (en) * | 1986-12-31 | 1997-03-25 | Genelabs Technologies, Inc. | HTLV-I peptide antigens and kit |
| US5643714A (en) * | 1986-12-31 | 1997-07-01 | Genelabs Technologies, Inc. | Method and assay for HTLV |
| JP2525054B2 (ja) * | 1989-08-01 | 1996-08-14 | 株式会社トクヤマ | 成人ｔ細胞白血病ウィルス感染診断薬 |
| US5164293A (en) * | 1990-09-25 | 1992-11-17 | Coulter Corporation | Monoclonal antibody for detecting HTLV-I, HTLV-II and STLV-I viruses |
| US6824977B2 (en) | 1999-04-06 | 2004-11-30 | New York University | Assays for human T cell lymphotrophic virus types I and II |
| US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323555A (en) * | 1980-11-03 | 1982-04-06 | The Regents Of The University Of California | Method of protecting cattle and sheep against bovine leukemia virus and vaccines for use therein |
| JPS58187861A (ja) * | 1982-04-26 | 1983-11-02 | Otsuka Pharmaceut Co Ltd | 成人型ｔ細胞性白血病関連抗体の測定法 |
| JPS6044870A (ja) * | 1983-08-22 | 1985-03-11 | Fujirebio Inc | 成人ｔ細胞白血病ウイルス抗体検出用試薬 |
-
1982
- 1982-09-30 JP JP57169670A patent/JPS5962527A/ja active Pending
-
1983
- 1983-09-23 US US06/535,457 patent/US4588681A/en not_active Expired - Lifetime
- 1983-09-28 EP EP83109691A patent/EP0105465B1/en not_active Expired - Lifetime
- 1983-09-28 DE DE8383109691T patent/DE3382121D1/de not_active Expired - Lifetime
- 1983-09-28 AT AT83109691T patent/ATE59963T1/de not_active IP Right Cessation
- 1983-09-30 PH PH29641A patent/PH19320A/en unknown
- 1983-09-30 KR KR1019830004655A patent/KR880001809B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US4588681A (en) | 1986-05-13 |
| EP0105465A3 (en) | 1986-11-20 |
| DE3382121D1 (de) | 1991-02-21 |
| EP0105465B1 (en) | 1991-01-16 |
| EP0105465A2 (en) | 1984-04-18 |
| ATE59963T1 (de) | 1991-02-15 |
| JPS5962527A (ja) | 1984-04-10 |
| PH19320A (en) | 1986-03-18 |
| KR880001809B1 (ko) | 1988-09-19 |
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