KR840005450A - 말론산에스테르의 이성화 방법 - Google Patents

말론산에스테르의 이성화 방법 Download PDF

Info

Publication number
KR840005450A
KR840005450A KR1019830002960A KR830002960A KR840005450A KR 840005450 A KR840005450 A KR 840005450A KR 1019830002960 A KR1019830002960 A KR 1019830002960A KR 830002960 A KR830002960 A KR 830002960A KR 840005450 A KR840005450 A KR 840005450A
Authority
KR
South Korea
Prior art keywords
isomerization
carried out
acid ester
formula
substituted
Prior art date
Application number
KR1019830002960A
Other languages
English (en)
Other versions
KR890000812B1 (ko
Inventor
마사유끼 나리사다 (외 3)
Original Assignee
요시또시 가즈오
시오노기 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시또시 가즈오, 시오노기 세이야꾸 가부시끼 가이샤 filed Critical 요시또시 가즈오
Publication of KR840005450A publication Critical patent/KR840005450A/ko
Application granted granted Critical
Publication of KR890000812B1 publication Critical patent/KR890000812B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

말론산에스테르의 이성화 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 염기로 식(Ⅱ)의 해당하는 이성체를 이성화 시켜 생성물을 침전시킴을 특징으로 하는식(Ⅰ)의 7β-말론아미도-7α-메톡시-3-테트라졸릴티오메틸-1-데티아-1-옥사-3-세펨-4-카르복실산 에스테르의 제조방법.
    상기식에서, Ar은 적절히 치환된 아릴 또는 헤테로고리기이다 ; Tet는 저급알킬기로 치환된 테트라졸릴기이다 ; B1및 B2는 페닐실린 또는 세팔로스포린 화학의 분야에서 각각 에스테르 형성기이다.
  2. 제1항에 있어서, Ar이 페닐, 히드록시페닐 또는 티에닐임을 특징으로 하는 방법.
  3. 제1항에 있어서, B1및 B2는 각각 같거나 또는 다른기로써, C1∼C6알킬 또는 할로겐에 의해 치환 가능한 C7∼C12아랄킬, C1∼C3-알콕시 또는 니트로기 임을 특징으로 하는 방법.
  4. 제1항에 있어서, 염기가 탄산수소알칼리금속, 3개의 저급알킬아민, 디에탄올아민, 트리에탄올아민,피리딘, 피콜린, 또는 루티딘으로부터 선택됨을 특징으로 하는 방법.
  5. 제1항에 있어서, 이성화는 벤젠, 디클로로메탄, 클로로포름, 에테르, 초산에틸, 메탄올, 에탄올, 물 및 이들의 혼합물로부터 선택된 용매에서 실행됨을 특징으로 하는 방법.
  6. 제1항에 있어서, 침전은 난용성 용매를 가하고, 농축 또는 결정화에 의해 실행됨을 특징으로 하는 방법.
  7. 제1항에 있어서, 이성화는 5분∼10시간동안, 0℃∼50℃의 온도에서 실행됨을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002960A 1982-07-02 1983-06-30 말론산에스테르의 이성화 방법 KR890000812B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP116048 1982-07-02
JP57116048A JPS597193A (ja) 1982-07-02 1982-07-02 マロニルメチル基の異性化方法

Publications (2)

Publication Number Publication Date
KR840005450A true KR840005450A (ko) 1984-11-12
KR890000812B1 KR890000812B1 (ko) 1989-04-08

Family

ID=14677411

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002960A KR890000812B1 (ko) 1982-07-02 1983-06-30 말론산에스테르의 이성화 방법

Country Status (30)

Country Link
US (1) US4504658A (ko)
EP (1) EP0098545B1 (ko)
JP (1) JPS597193A (ko)
KR (1) KR890000812B1 (ko)
AR (1) AR242391A1 (ko)
AT (1) ATE19401T1 (ko)
AU (1) AU564850B2 (ko)
BG (1) BG37526A3 (ko)
CA (1) CA1192193A (ko)
CS (1) CS244940B2 (ko)
DD (1) DD210052A5 (ko)
DE (2) DE3363161D1 (ko)
DK (1) DK160502C (ko)
EG (1) EG16539A (ko)
ES (1) ES8500954A1 (ko)
FI (1) FI832407L (ko)
GB (1) GB2124217B (ko)
GR (1) GR78620B (ko)
HU (1) HU187944B (ko)
IE (1) IE55767B1 (ko)
IL (1) IL69146A (ko)
NO (1) NO832387L (ko)
NZ (1) NZ204627A (ko)
PH (1) PH21139A (ko)
PL (1) PL141782B1 (ko)
PT (1) PT76973B (ko)
RO (1) RO86355B (ko)
SU (1) SU1225488A3 (ko)
YU (1) YU44011B (ko)
ZA (1) ZA834495B (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60123490A (ja) * 1983-12-07 1985-07-02 Shionogi & Co Ltd マロニルオキサセフェムカルボン酸誘導体
US4998060A (en) * 1989-07-12 1991-03-05 Pacific Scientific Company Fault indicator with hot stick clamping mechanism
JP2006028154A (ja) * 2004-06-14 2006-02-02 Sumitomo Chemical Co Ltd 光学活性化合物の製造方法
CN102260280A (zh) * 2010-05-28 2011-11-30 上海医药工业研究院 拉氧头孢钠的制备方法
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
AU2011317067A1 (en) 2010-10-20 2013-05-23 Bioformix, Inc. Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
JP2014532625A (ja) 2011-10-19 2014-12-08 シラス・インコーポレイテッド メチレンβ−ジケトンモノマー、メチレンβ−ジケトンモノマーを製造するための方法、これらから作られる重合可能な組成物および製品
US9234107B2 (en) 2012-03-30 2016-01-12 Sirrus, Inc. Ink coating formulations and polymerizable systems for producing the same
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
JP6188252B2 (ja) 2012-03-30 2017-08-30 シラス・インコーポレイテッド 重合性組成物の活性化方法、重合系およびこれにより形成される製品
US10047192B2 (en) 2012-06-01 2018-08-14 Sirrus, Inc. Optical material and articles formed therefrom
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
CN105164797B (zh) 2012-11-30 2019-04-19 瑟拉斯公司 用于电子应用的复合组合物
WO2014110388A1 (en) 2013-01-11 2014-07-17 Bioformix Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
KR102115644B1 (ko) * 2017-09-13 2020-05-27 주식회사 동도물산 7α-알콕시옥사세펨 중간체의 제조방법
CN112480147A (zh) * 2019-09-12 2021-03-12 杭州森泽医药科技有限公司 一种拉氧头孢中间体溶剂化物及其制备方法和表征

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) * 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US4167630A (en) * 1975-12-24 1979-09-11 Merck & Co., Inc. Process for epimerizing beta-lactam antibiotic compounds, and related products
CA1085392A (en) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
US4234596A (en) * 1976-11-19 1980-11-18 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4259485A (en) * 1979-04-24 1981-03-31 Eli Lilly And Company Crystallization process
US4252953A (en) * 1979-05-01 1981-02-24 Eli Lilly And Company Antibiotic crystalline epimer
US4320055A (en) * 1980-04-07 1982-03-16 Eli Lilly And Company Process for penicillin epimerization
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam

Also Published As

Publication number Publication date
JPS597193A (ja) 1984-01-14
HU187944B (en) 1986-03-28
US4504658A (en) 1985-03-12
PL242776A1 (en) 1984-08-13
GB2124217A (en) 1984-02-15
RO86355A (ro) 1985-03-15
IE55767B1 (en) 1991-01-16
AU564850B2 (en) 1987-08-27
DD210052A5 (de) 1984-05-30
PT76973A (en) 1983-08-01
DE3363161D1 (en) 1986-05-28
GB2124217B (en) 1985-09-04
FI832407A0 (fi) 1983-06-30
EP0098545B1 (en) 1986-04-23
EG16539A (en) 1989-03-30
CA1192193A (en) 1985-08-20
ATE19401T1 (de) 1986-05-15
DK160502B (da) 1991-03-18
SU1225488A3 (ru) 1986-04-15
IE831527L (en) 1984-01-02
DK160502C (da) 1991-08-26
BG37526A3 (en) 1985-06-14
CS503683A2 (en) 1985-09-17
DK304983D0 (da) 1983-07-01
GR78620B (ko) 1984-09-27
YU44011B (en) 1990-02-28
JPH0149271B2 (ko) 1989-10-24
EP0098545A1 (en) 1984-01-18
AR242391A1 (es) 1993-03-31
PL141782B1 (en) 1987-08-31
IL69146A (en) 1987-01-30
ES523774A0 (es) 1984-11-01
DE98545T1 (de) 1984-08-16
PH21139A (en) 1987-07-27
PT76973B (en) 1986-01-24
CS244940B2 (en) 1986-08-14
ES8500954A1 (es) 1984-11-01
DK304983A (da) 1984-01-03
RO86355B (ro) 1985-03-31
AU1649683A (en) 1984-01-05
FI832407L (fi) 1984-01-03
GB8317634D0 (en) 1983-08-03
YU144583A (en) 1986-02-28
NZ204627A (en) 1986-04-11
KR890000812B1 (ko) 1989-04-08
NO832387L (no) 1984-01-03
ZA834495B (en) 1984-07-25

Similar Documents

Publication Publication Date Title
KR840005450A (ko) 말론산에스테르의 이성화 방법
KR840006994A (ko) 트리스(피페리딜아미노트리아질아미노) 화합물 및 이의 산부가염의 제조방법
KR850004492A (ko) 옥시캄의 엔올 에테르 유도체의 제조방법
DK154831C (da) Fremgangsmaade til fremstilling af 1-desoxy-nojirimycin-derivater eller salte deraf
KR840006338A (ko) 4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법
KR850005845A (ko) 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법
KR850008165A (ko) 헤테로사이클릭 유도체의 제조방법
KR840006482A (ko) 디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법
KR860001065A (ko) 4-아세톡시-3-히드록시에틸아제티진-2-온유도체의 제조방법
ES427548A1 (es) Procedimiento para la preparacion de 2,2,6,6-tetrametil-4- oxopiperidina.
KR870002062A (ko) 2,3-디히드로-1h-인덴 유도체의 제조 방법
GB1129158A (en) Coronary dilating compositions
US2334711A (en) Ctanine dyestdff intermediates
KR840001968A (ko) 4-페닐퀴나졸린 유도체의 제조방법
KR840004065A (ko) 2-시아노-2-프로페노산 및 그 유도체의 제조방법
KR840005723A (ko) 티아졸유도체의 제조방법
KR840005107A (ko) 피리미디온 및 그의 산부가염의 제조방법
ES407479A1 (es) Un metodo para preparar una 2,4-diamino-5-bencilpirimidina.
KR890005099A (ko) 결정상 항생제 중간물질
KR840001947A (ko) 페녹시알킬아마이드 유도체의 제조방법
KR860008123A (ko) 신규 디아민 유도체의 제조방법
KR850004758A (ko) 피라졸로 피리딘 유도체의 제법
KR850007425A (ko) 세팔로스포린 유도체와 이의 염의 제조방법
KR860003229A (ko) 피라졸론 유도체의 제조방법
GB1351358A (en) Method of making benzoxazines

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20010223

Year of fee payment: 13

LAPS Lapse due to unpaid annual fee