KR840002406A - 3위치가 티오메틸 복소환 그룹에 의해 치환된 신규의 세팔로스포린유도체의 제조방법세 - Google Patents
3위치가 티오메틸 복소환 그룹에 의해 치환된 신규의 세팔로스포린유도체의 제조방법세 Download PDFInfo
- Publication number
- KR840002406A KR840002406A KR1019820005370A KR820005370A KR840002406A KR 840002406 A KR840002406 A KR 840002406A KR 1019820005370 A KR1019820005370 A KR 1019820005370A KR 820005370 A KR820005370 A KR 820005370A KR 840002406 A KR840002406 A KR 840002406A
- Authority
- KR
- South Korea
- Prior art keywords
- represent
- producing
- thiomethyl
- group
- substituted
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title claims 2
- 229940124587 cephalosporin Drugs 0.000 title claims 2
- 150000001780 cephalosporins Chemical class 0.000 title claims 2
- 125000000623 heterocyclic group Chemical group 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 3
- -1 1,3-propylene group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- JENXPZOBCRINRF-KGMSYRRLSA-N (6R)-7-amino-3-(bromomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-4-carboxylic acid Chemical compound S1C(C(O)=O)C(CBr)=CN2C(=O)C(N)[C@H]21 JENXPZOBCRINRF-KGMSYRRLSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000002373 hemiacetals Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- NYBWUHOMYZZKOR-UHFFFAOYSA-N tes-adt Chemical class C1=C2C(C#C[Si](CC)(CC)CC)=C(C=C3C(SC=C3)=C3)C3=C(C#C[Si](CC)(CC)CC)C2=CC2=C1SC=C2 NYBWUHOMYZZKOR-UHFFFAOYSA-N 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Tunnel Furnaces (AREA)
- Noodles (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Polyesters Or Polycarbonates (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 무수물로 전환시켜 활성화시킨 트리틸과 같은 일반식여기서 R1및 R2각각으로는 각각 메틸 그룹을 나타내며, R1및 R2모두로는 1,3-프로필렌 그룹을 나타내며, Tr은 보호그룹을 나타낸다)의 산으로 디메틸포름아미드와 같은 용매내에서 tret 부틸 S-옥사이드-1의 7-아미노 3-브로모메틸 3-세펨카르복실레이트를 아실화시킨다음 수득한 생성물을 일반식 R3SH의 티올상에서 디메틸포름아미드와 같은 적합한 용매존재하 0 내지 50℃, 특히 알카리성제의 존재하에서 반응시키며, 이어서 가수분해와 같은 공지의 방법으로 수득한 생성물의 산 관능기와 아민상에 위치된 보호그룹을 제거시킨후, 산 관능기를 공지의 방법으로 염 또는 에스테르로 전환시킴을 특징으로 하여 하기 일반식(II)의 세팔로스포린 및 그의 syn 이성체 또는 anti 이성체 또는 이들의 이성체 혼합물의 제조방법.상기 식에서R1및 R2각각으로는 각각 메틸그룹을 나타내며 R1및 R2모두로는 1,3-프로필렌 그룹을 나타내며R3는 하기 일반식 a),b),c) 복소환을 나타내며A는 수소, 양이온 또는 쉽게 가수분해 되거나 또는 대사 기능적으로 화학변화를 일으키며 약학적으로 무독한 에스테르 또는 헤미아세탈을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8122506A FR2517309A1 (fr) | 1981-12-01 | 1981-12-01 | Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant |
FR81/22506 | 1981-12-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840002406A true KR840002406A (ko) | 1984-07-21 |
KR880001775B1 KR880001775B1 (ko) | 1988-09-15 |
Family
ID=9264556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8205370A KR880001775B1 (ko) | 1981-12-01 | 1982-11-30 | 3위치가 티오메틸 헤테로 고리기에 의해 치환된 세팔로스포린 유도체의 제조방법 |
Country Status (30)
Country | Link |
---|---|
US (1) | US4609654A (ko) |
EP (1) | EP0080944B1 (ko) |
JP (1) | JPS58103392A (ko) |
KR (1) | KR880001775B1 (ko) |
AT (1) | ATE15199T1 (ko) |
AU (1) | AU564235B2 (ko) |
CA (1) | CA1189854A (ko) |
CS (1) | CS232743B2 (ko) |
DD (1) | DD204257A5 (ko) |
DE (1) | DE3265901D1 (ko) |
DK (1) | DK532282A (ko) |
EG (1) | EG15644A (ko) |
ES (1) | ES517840A0 (ko) |
FI (1) | FI73221C (ko) |
FR (1) | FR2517309A1 (ko) |
GR (1) | GR76739B (ko) |
HU (2) | HU186999B (ko) |
IE (1) | IE54173B1 (ko) |
IL (1) | IL67285A (ko) |
MA (1) | MA19659A1 (ko) |
NO (1) | NO159857C (ko) |
NZ (1) | NZ202658A (ko) |
OA (1) | OA07262A (ko) |
PH (1) | PH18949A (ko) |
PL (1) | PL132054B1 (ko) |
PT (1) | PT75905B (ko) |
SG (1) | SG12188G (ko) |
SU (1) | SU1114338A3 (ko) |
YU (1) | YU265482A (ko) |
ZA (1) | ZA828598B (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60142987A (ja) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体 |
DE3485860T2 (de) * | 1983-12-29 | 1993-01-14 | Mochida Pharm Co Ltd | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US4812562A (en) * | 1985-07-25 | 1989-03-14 | Taisho Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
HU196814B (en) * | 1985-10-22 | 1989-01-30 | Biogal Gyogyszergyar | Process for producing new cepheme-carboxylic acid derivatives |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
JPS63132893A (ja) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB694060A (en) * | 1949-12-27 | 1953-07-15 | Bataafsche Petroleum | Process for the manufacture of ethers of glycerols |
US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
ES8103101A1 (es) * | 1979-03-22 | 1981-02-16 | Glaxo Group Ltd | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
-
1981
- 1981-12-01 FR FR8122506A patent/FR2517309A1/fr active Granted
-
1982
- 1982-11-15 IE IE2721/82A patent/IE54173B1/en unknown
- 1982-11-17 IL IL67285A patent/IL67285A/xx unknown
- 1982-11-22 CA CA000416077A patent/CA1189854A/en not_active Expired
- 1982-11-22 ZA ZA828598A patent/ZA828598B/xx unknown
- 1982-11-23 US US06/443,933 patent/US4609654A/en not_active Expired - Fee Related
- 1982-11-24 NO NO823930A patent/NO159857C/no unknown
- 1982-11-24 FI FI824043A patent/FI73221C/fi not_active IP Right Cessation
- 1982-11-25 PH PH28193A patent/PH18949A/en unknown
- 1982-11-26 PT PT75905A patent/PT75905B/pt unknown
- 1982-11-26 AT AT82402151T patent/ATE15199T1/de not_active IP Right Cessation
- 1982-11-26 DE DE8282402151T patent/DE3265901D1/de not_active Expired
- 1982-11-26 EP EP82402151A patent/EP0080944B1/fr not_active Expired
- 1982-11-26 YU YU02654/82A patent/YU265482A/xx unknown
- 1982-11-29 EG EG702/82A patent/EG15644A/xx active
- 1982-11-29 AU AU90948/82A patent/AU564235B2/en not_active Ceased
- 1982-11-30 PL PL1982239271A patent/PL132054B1/pl unknown
- 1982-11-30 DK DK532282A patent/DK532282A/da not_active Application Discontinuation
- 1982-11-30 SU SU823519544A patent/SU1114338A3/ru active
- 1982-11-30 CS CS828595A patent/CS232743B2/cs unknown
- 1982-11-30 NZ NZ202658A patent/NZ202658A/en unknown
- 1982-11-30 HU HU823839A patent/HU186999B/hu not_active IP Right Cessation
- 1982-11-30 HU HU823839A patent/HU186998B/hu not_active IP Right Cessation
- 1982-11-30 KR KR8205370A patent/KR880001775B1/ko active
- 1982-11-30 GR GR69934A patent/GR76739B/el unknown
- 1982-11-30 ES ES517840A patent/ES517840A0/es active Granted
- 1982-11-30 JP JP57208755A patent/JPS58103392A/ja active Pending
- 1982-12-01 DD DD82245454A patent/DD204257A5/de unknown
- 1982-12-01 MA MA19872A patent/MA19659A1/fr unknown
- 1982-12-01 OA OA57856A patent/OA07262A/xx unknown
-
1988
- 1988-02-19 SG SG121/88A patent/SG12188G/en unknown
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