KR830000911A - X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액 - Google Patents

X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액 Download PDF

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Publication number
KR830000911A
KR830000911A KR1019790002214A KR790002214A KR830000911A KR 830000911 A KR830000911 A KR 830000911A KR 1019790002214 A KR1019790002214 A KR 1019790002214A KR 790002214 A KR790002214 A KR 790002214A KR 830000911 A KR830000911 A KR 830000911A
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KR
South Korea
Prior art keywords
ray contrast
group
hydrogen atom
alkyl
preparing
Prior art date
Application number
KR1019790002214A
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English (en)
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KR830001643B1 (ko
Inventor
베른하르트 라클리 프리드트조브
제임스 켈리 마이클
Original Assignee
울프 블릭스
나이가드 앤드 캄파니 에이/에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1019790002214A priority Critical patent/KR830001643B1/ko
Priority to IT49618/79A priority patent/IT1193761B/it
Application filed by 울프 블릭스, 나이가드 앤드 캄파니 에이/에스 filed Critical 울프 블릭스
Priority to ES482131A priority patent/ES482131A0/es
Priority to SE7905830A priority patent/SE445971B/sv
Priority to ZA793313A priority patent/ZA793313B/xx
Priority to AT0464479A priority patent/AT371998B/de
Priority to DK280979A priority patent/DK155714C/da
Priority to NLAANVRAGE7905166,A priority patent/NL183121C/xx
Priority to CA331,006A priority patent/CA1132901A/en
Priority to DE2926850A priority patent/DE2926850C2/de
Priority to AR277172A priority patent/AR222337A1/es
Priority to JP8356579A priority patent/JPS5531068A/ja
Priority to CH6221/79A priority patent/CH649469A5/de
Priority to FR7917239A priority patent/FR2435253A1/fr
Priority to AU48615/79A priority patent/AU523295B2/en
Priority to NZ190907A priority patent/NZ190907A/xx
Priority to BE0/196098A priority patent/BE877443A/fr
Priority to US06/054,440 priority patent/US4278654A/en
Priority to FI792101A priority patent/FI75492C/fi
Priority to PT69869A priority patent/PT69869A/pt
Priority to GB7923277A priority patent/GB2031405B/en
Priority to IE1241/79A priority patent/IE48437B1/en
Priority to US06/233,137 priority patent/US4396597A/en
Publication of KR830000911A publication Critical patent/KR830000911A/ko
Application granted granted Critical
Publication of KR830001643B1 publication Critical patent/KR830001643B1/ko
Priority to SG57/84A priority patent/SG5784G/en
Priority to HK599/84A priority patent/HK59984A/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 X-선콘트라스트 제제 및 완충액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(I)의m-카복스아미도-0-요오도-N-(β-하이드록시알킬)아닐린 x-선 콘트라스트제제의 용액을 생리적으로 가능한 완충액 시스템(여기서 완충액의 pH치는 온도가 상승함에 따라 감소된다)의 존재하에서 가압멸균시킴을 특징으로 하여 x-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액을 제조하는 방법.
    상기 구조식에서
    R1- (a)의 그룹이고, 여기서 R' 및 R˝는 같거나 다르게 수소원자 또는 탄소수 1 내지 4의 알킬그룹(필요한 경우 하나 또는 그 이상의 -OH 그룹을 운반할 수도 있다)이며, 또는
    (b) 2,3 또는 4-위치에 β-OH 그룹을 갖는 당의 잔기이고, 여기서 -OH그룹은 아세트 아미도 질소원자에 대해 β위치의 탄소원자에 결합되어 있으며,
    R2는 아실그룹이고
    R3및 R4는 같거나 다르게 각각 수소원자 또는 알킬, 하이드록시알킬 또는 아실옥시알킬그룹이거나 또는 당의 잔기이고
    R5는 수소원자 또는 -CONR3˝R4˝, AC'NR6또는 -CH2NAC'R6이고, 여기서 R3˝ 및 R4˝는 같거나 다르게 각각 수소원자 또는 알킬, 하이드록시 알킬 또는 아실옥시알킬그룹이거나 또는 당의 잔기이고 R6는 수소원자 또는 알킬, 하이드록시알킬, 아실옥시알킬 또는 아실그룹이다.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019790002214A 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법 KR830001643B1 (ko)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR7917239A FR2435253A1 (fr) 1978-07-04 1979-07-03 Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede
ES482131A ES482131A0 (es) 1978-07-04 1979-07-03 Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina.
IT49618/79A IT1193761B (it) 1978-07-04 1979-07-03 Procedimento per preparare una soluzione sterile stabile di un agente di cotrasto per raggi x
ZA793313A ZA793313B (en) 1978-07-04 1979-07-03 A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
AT0464479A AT371998B (de) 1978-07-04 1979-07-03 Verfahren zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels
DK280979A DK155714C (da) 1978-07-04 1979-07-03 Fremgangsmaade til fremstilling af en steril, injicerbar, fysiologisk acceptabel oploesning af et roentgenkontrastmiddel, samt en oploesning af roentgenkontrastmidlet til brug ved fremgangsmaaden
NLAANVRAGE7905166,A NL183121C (nl) 1978-07-04 1979-07-03 Werkwijze voor het bereiden van een steriele, injecteerbare, fysiologisch aanvaardbare oplossing van een niet-ionogeen roentgencontrastmiddel.
CA331,006A CA1132901A (en) 1978-07-04 1979-07-03 Aniline x-ray agent and buffer whose ph decreases with temperature
DE2926850A DE2926850C2 (de) 1978-07-04 1979-07-03 Verfahren zur Herstellung einer sterilen injizierbaren physiologisch annehmbaren Lösung eines nicht ionischen m-Carboxamido-o-jodo-N-(β-hydroxyalkyl)-anilin-Röntgenkontrastmittels und Lösungen des Röntgenkontrastmittels und eines Puffers
NZ190907A NZ190907A (en) 1978-07-04 1979-07-03 Preparation of x-ray contrast agent by autoclaving a meta-carboxamido-ortho-iodo-n-(betahydroxyalkyl)-aniline
JP8356579A JPS5531068A (en) 1978-07-04 1979-07-03 Manufacture of x ray contrast agent injectable sterilized solution
CH6221/79A CH649469A5 (de) 1978-07-04 1979-07-03 Loesung eines roentgenkontrastmittels und eines puffers und ihre verwendung zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels.
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법
SE7905830A SE445971B (sv) 1978-07-04 1979-07-03 Forfarande for framstellning av injicerbart rontgenkontrastmedel samt en losning av nemnda medel
AR277172A AR222337A1 (es) 1978-07-04 1979-07-03 Procedimiento para preparar una solucion esteril inyectable fisiologicamente aceptable de un agente de contraste de rayos x
BE0/196098A BE877443A (fr) 1978-07-04 1979-07-03 Procede de preparation d'unesolution tamponnee d'une substance de contraste pour rayons x
US06/054,440 US4278654A (en) 1978-07-04 1979-07-03 Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer
FI792101A FI75492C (fi) 1978-07-04 1979-07-03 Foerfarande foer framstaellning av en steril, injicerbar, fysiologiskt godtagbar loesning av ett roentgenkontrastmedel samt en som utgaongsmaterial anvaend loesning av ett roentgenkontrastmedel och ett fysiologiskt godtagbart buffertsystem.
PT69869A PT69869A (en) 1978-07-04 1979-07-03 A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agentand solutions of the x-ray contrast agent and a buffer
AU48615/79A AU523295B2 (en) 1978-07-04 1979-07-03 X-ray contrast agent
GB7923277A GB2031405B (en) 1978-07-04 1979-07-04 Process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
IE1241/79A IE48437B1 (en) 1978-07-04 1979-08-08 A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
US06/233,137 US4396597A (en) 1978-07-04 1981-02-10 Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer
SG57/84A SG5784G (en) 1978-07-04 1984-01-21 A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
HK599/84A HK59984A (en) 1978-07-04 1984-08-02 A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7828764 1978-07-04
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법

Publications (2)

Publication Number Publication Date
KR830000911A true KR830000911A (ko) 1983-04-28
KR830001643B1 KR830001643B1 (ko) 1983-08-22

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Application Number Title Priority Date Filing Date
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법

Country Status (22)

Country Link
US (2) US4278654A (ko)
JP (1) JPS5531068A (ko)
KR (1) KR830001643B1 (ko)
AR (1) AR222337A1 (ko)
AT (1) AT371998B (ko)
AU (1) AU523295B2 (ko)
BE (1) BE877443A (ko)
CA (1) CA1132901A (ko)
CH (1) CH649469A5 (ko)
DE (1) DE2926850C2 (ko)
DK (1) DK155714C (ko)
ES (1) ES482131A0 (ko)
FI (1) FI75492C (ko)
FR (1) FR2435253A1 (ko)
HK (1) HK59984A (ko)
IT (1) IT1193761B (ko)
NL (1) NL183121C (ko)
NZ (1) NZ190907A (ko)
PT (1) PT69869A (ko)
SE (1) SE445971B (ko)
SG (1) SG5784G (ko)
ZA (1) ZA793313B (ko)

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Also Published As

Publication number Publication date
US4396597A (en) 1983-08-02
ATA464479A (de) 1983-01-15
IT7949618A0 (it) 1979-07-03
NZ190907A (en) 1981-10-19
JPS6210209B2 (ko) 1987-03-05
JPS5531068A (en) 1980-03-05
DE2926850A1 (de) 1980-03-06
CA1132901A (en) 1982-10-05
SG5784G (en) 1985-02-01
SE7905830L (sv) 1980-01-05
ZA793313B (en) 1980-08-27
HK59984A (en) 1984-08-10
AR222337A1 (es) 1981-05-15
FR2435253B1 (ko) 1984-03-16
FR2435253A1 (fr) 1980-04-04
DK155714C (da) 1989-10-30
NL183121C (nl) 1988-08-01
NL7905166A (nl) 1980-01-08
US4278654A (en) 1981-07-14
ES8200082A1 (es) 1980-12-16
FI792101A (fi) 1980-01-05
ES482131A0 (es) 1980-12-16
KR830001643B1 (ko) 1983-08-22
FI75492C (fi) 1988-07-11
DK280979A (da) 1980-01-05
CH649469A5 (de) 1985-05-31
SE445971B (sv) 1986-08-04
DK155714B (da) 1989-05-08
IT1193761B (it) 1988-08-24
BE877443A (fr) 1980-01-03
PT69869A (en) 1979-08-01
AU523295B2 (en) 1982-07-22
NL183121B (nl) 1988-03-01
DE2926850C2 (de) 1985-01-24
AT371998B (de) 1983-08-25
AU4861579A (en) 1980-02-07
FI75492B (fi) 1988-03-31

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