KR830000911A - X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액 - Google Patents
X-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액의 제조방법 및 x-선콘트라스트 제제 및 완충액 Download PDFInfo
- Publication number
- KR830000911A KR830000911A KR1019790002214A KR790002214A KR830000911A KR 830000911 A KR830000911 A KR 830000911A KR 1019790002214 A KR1019790002214 A KR 1019790002214A KR 790002214 A KR790002214 A KR 790002214A KR 830000911 A KR830000911 A KR 830000911A
- Authority
- KR
- South Korea
- Prior art keywords
- ray contrast
- group
- hydrogen atom
- alkyl
- preparing
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(I)의m-카복스아미도-0-요오도-N-(β-하이드록시알킬)아닐린 x-선 콘트라스트제제의 용액을 생리적으로 가능한 완충액 시스템(여기서 완충액의 pH치는 온도가 상승함에 따라 감소된다)의 존재하에서 가압멸균시킴을 특징으로 하여 x-선 콘트라스트제제의 살균된 주사용의 생리적으로 가능한 용액을 제조하는 방법.상기 구조식에서R1- (a)의 그룹이고, 여기서 R' 및 R˝는 같거나 다르게 수소원자 또는 탄소수 1 내지 4의 알킬그룹(필요한 경우 하나 또는 그 이상의 -OH 그룹을 운반할 수도 있다)이며, 또는(b) 2,3 또는 4-위치에 β-OH 그룹을 갖는 당의 잔기이고, 여기서 -OH그룹은 아세트 아미도 질소원자에 대해 β위치의 탄소원자에 결합되어 있으며,R2는 아실그룹이고R3및 R4는 같거나 다르게 각각 수소원자 또는 알킬, 하이드록시알킬 또는 아실옥시알킬그룹이거나 또는 당의 잔기이고R5는 수소원자 또는 -CONR3˝R4˝, AC'NR6또는 -CH2NAC'R6이고, 여기서 R3˝ 및 R4˝는 같거나 다르게 각각 수소원자 또는 알킬, 하이드록시 알킬 또는 아실옥시알킬그룹이거나 또는 당의 잔기이고 R6는 수소원자 또는 알킬, 하이드록시알킬, 아실옥시알킬 또는 아실그룹이다.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7917239A FR2435253A1 (fr) | 1978-07-04 | 1979-07-03 | Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede |
ES482131A ES482131A0 (es) | 1978-07-04 | 1979-07-03 | Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina. |
IT49618/79A IT1193761B (it) | 1978-07-04 | 1979-07-03 | Procedimento per preparare una soluzione sterile stabile di un agente di cotrasto per raggi x |
ZA793313A ZA793313B (en) | 1978-07-04 | 1979-07-03 | A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer |
AT0464479A AT371998B (de) | 1978-07-04 | 1979-07-03 | Verfahren zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels |
DK280979A DK155714C (da) | 1978-07-04 | 1979-07-03 | Fremgangsmaade til fremstilling af en steril, injicerbar, fysiologisk acceptabel oploesning af et roentgenkontrastmiddel, samt en oploesning af roentgenkontrastmidlet til brug ved fremgangsmaaden |
NLAANVRAGE7905166,A NL183121C (nl) | 1978-07-04 | 1979-07-03 | Werkwijze voor het bereiden van een steriele, injecteerbare, fysiologisch aanvaardbare oplossing van een niet-ionogeen roentgencontrastmiddel. |
CA331,006A CA1132901A (en) | 1978-07-04 | 1979-07-03 | Aniline x-ray agent and buffer whose ph decreases with temperature |
DE2926850A DE2926850C2 (de) | 1978-07-04 | 1979-07-03 | Verfahren zur Herstellung einer sterilen injizierbaren physiologisch annehmbaren Lösung eines nicht ionischen m-Carboxamido-o-jodo-N-(β-hydroxyalkyl)-anilin-Röntgenkontrastmittels und Lösungen des Röntgenkontrastmittels und eines Puffers |
NZ190907A NZ190907A (en) | 1978-07-04 | 1979-07-03 | Preparation of x-ray contrast agent by autoclaving a meta-carboxamido-ortho-iodo-n-(betahydroxyalkyl)-aniline |
JP8356579A JPS5531068A (en) | 1978-07-04 | 1979-07-03 | Manufacture of x ray contrast agent injectable sterilized solution |
CH6221/79A CH649469A5 (de) | 1978-07-04 | 1979-07-03 | Loesung eines roentgenkontrastmittels und eines puffers und ihre verwendung zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels. |
KR1019790002214A KR830001643B1 (ko) | 1978-07-04 | 1979-07-03 | X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법 |
SE7905830A SE445971B (sv) | 1978-07-04 | 1979-07-03 | Forfarande for framstellning av injicerbart rontgenkontrastmedel samt en losning av nemnda medel |
AR277172A AR222337A1 (es) | 1978-07-04 | 1979-07-03 | Procedimiento para preparar una solucion esteril inyectable fisiologicamente aceptable de un agente de contraste de rayos x |
BE0/196098A BE877443A (fr) | 1978-07-04 | 1979-07-03 | Procede de preparation d'unesolution tamponnee d'une substance de contraste pour rayons x |
US06/054,440 US4278654A (en) | 1978-07-04 | 1979-07-03 | Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer |
FI792101A FI75492C (fi) | 1978-07-04 | 1979-07-03 | Foerfarande foer framstaellning av en steril, injicerbar, fysiologiskt godtagbar loesning av ett roentgenkontrastmedel samt en som utgaongsmaterial anvaend loesning av ett roentgenkontrastmedel och ett fysiologiskt godtagbart buffertsystem. |
PT69869A PT69869A (en) | 1978-07-04 | 1979-07-03 | A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agentand solutions of the x-ray contrast agent and a buffer |
AU48615/79A AU523295B2 (en) | 1978-07-04 | 1979-07-03 | X-ray contrast agent |
GB7923277A GB2031405B (en) | 1978-07-04 | 1979-07-04 | Process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer |
IE1241/79A IE48437B1 (en) | 1978-07-04 | 1979-08-08 | A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer |
US06/233,137 US4396597A (en) | 1978-07-04 | 1981-02-10 | Process for the preparation of a sterile injectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer |
SG57/84A SG5784G (en) | 1978-07-04 | 1984-01-21 | A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer |
HK599/84A HK59984A (en) | 1978-07-04 | 1984-08-02 | A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7828764 | 1978-07-04 | ||
KR1019790002214A KR830001643B1 (ko) | 1978-07-04 | 1979-07-03 | X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830000911A true KR830000911A (ko) | 1983-04-28 |
KR830001643B1 KR830001643B1 (ko) | 1983-08-22 |
Family
ID=26268114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019790002214A KR830001643B1 (ko) | 1978-07-04 | 1979-07-03 | X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법 |
Country Status (22)
Country | Link |
---|---|
US (2) | US4278654A (ko) |
JP (1) | JPS5531068A (ko) |
KR (1) | KR830001643B1 (ko) |
AR (1) | AR222337A1 (ko) |
AT (1) | AT371998B (ko) |
AU (1) | AU523295B2 (ko) |
BE (1) | BE877443A (ko) |
CA (1) | CA1132901A (ko) |
CH (1) | CH649469A5 (ko) |
DE (1) | DE2926850C2 (ko) |
DK (1) | DK155714C (ko) |
ES (1) | ES482131A0 (ko) |
FI (1) | FI75492C (ko) |
FR (1) | FR2435253A1 (ko) |
HK (1) | HK59984A (ko) |
IT (1) | IT1193761B (ko) |
NL (1) | NL183121C (ko) |
NZ (1) | NZ190907A (ko) |
PT (1) | PT69869A (ko) |
SE (1) | SE445971B (ko) |
SG (1) | SG5784G (ko) |
ZA (1) | ZA793313B (ko) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
DE3689330T2 (de) * | 1985-08-09 | 1994-05-19 | Cook Imaging Corp | Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln. |
US5035877A (en) * | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
US4718463A (en) * | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US5847009A (en) | 1986-01-14 | 1998-12-08 | Alliance Pharmaceutical Corp. | Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
US4863714A (en) * | 1987-02-05 | 1989-09-05 | Cook Imaging Corporation | Sterilization of compositions of limited stability |
IL94718A (en) * | 1989-07-05 | 1994-10-21 | Schering Ag | Non-ionic carboxamide contrast agent and method of preparation |
US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
DE4111939A1 (de) * | 1991-04-12 | 1992-10-22 | Fresenius Ag | Parenteral verabreichbare, hitzesterilisierbare o/w-emulsion eines roentgenkontrastmittels |
US5169864A (en) * | 1991-11-15 | 1992-12-08 | Baxter International Inc. | Unbuffered premixed ranitidine formulation |
DE4316722A1 (de) * | 1993-05-19 | 1994-11-24 | Fresenius Ag | Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels |
CZ234898A3 (cs) * | 1996-01-25 | 1998-11-11 | Schering Aktiengesellschaft | Zdokonalené koncentrované injekční a infusní roztoky pro intravazální použití |
DE19648650C2 (de) * | 1996-01-29 | 1998-07-02 | Schering Ag | Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung |
US6072069A (en) * | 1998-11-04 | 2000-06-06 | Biophysica, Inc. | Biodegradable nonionic contrast media |
US7250153B2 (en) * | 2002-12-12 | 2007-07-31 | Biophysica Research, Inc. | Contrast media formulations having improved biological tolerance |
JP5947784B2 (ja) * | 2010-03-23 | 2016-07-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 安定化x線診断用組成物の製法 |
WO2013180777A1 (en) * | 2012-05-30 | 2013-12-05 | Verrow Pharmaceuticals, Inc. | Stabilized formulations containing iodinated contrast agents and cyclodextrins |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3758E (fr) * | 1905-02-21 | Jules Cesar Napoleon Fouilloy | Collier d'attache pour protecteur antidérapant de pneumatiques | |
NL127881C (ko) * | 1963-03-25 | |||
GB1069437A (en) * | 1963-10-23 | 1967-05-17 | Nyegaard & Co As | Injectable x-ray contrast media |
US3733397A (en) * | 1966-12-02 | 1973-05-15 | Pharmacia Ab | Method for the x-ray visualization of body cavities and a preparation for carrying out the method |
SE315975B (ko) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
GB1321591A (en) * | 1969-06-27 | 1973-06-27 | Nyegaard & Co As | Non-ionic iodinated x-ray contrast agents |
US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
CH583562A5 (ko) * | 1973-07-17 | 1977-01-14 | Bracco Ind Chimica Spa | |
GB1495679A (en) * | 1974-06-17 | 1977-12-21 | Mallinckrodt Inc | Substituted isophthalamic acids |
US3953497A (en) * | 1974-07-29 | 1976-04-27 | Mallinckrodt, Inc. | 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof |
GB1514920A (en) * | 1974-10-09 | 1978-06-21 | Reckitt & Colmann Prod Ltd | Dispensing container for medicinal foams |
FI760068A (ko) * | 1975-02-03 | 1976-08-04 | Schering Ag | |
DE2505218A1 (de) * | 1975-02-05 | 1976-08-19 | Schering Ag | Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung |
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE2629228C2 (de) * | 1976-06-25 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung |
US4256729A (en) * | 1979-03-23 | 1981-03-17 | Mallinckrodt, Inc. | N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same |
-
1979
- 1979-07-03 CH CH6221/79A patent/CH649469A5/de not_active IP Right Cessation
- 1979-07-03 NL NLAANVRAGE7905166,A patent/NL183121C/xx not_active IP Right Cessation
- 1979-07-03 FI FI792101A patent/FI75492C/fi not_active IP Right Cessation
- 1979-07-03 IT IT49618/79A patent/IT1193761B/it active
- 1979-07-03 ES ES482131A patent/ES482131A0/es active Granted
- 1979-07-03 ZA ZA793313A patent/ZA793313B/xx unknown
- 1979-07-03 BE BE0/196098A patent/BE877443A/fr not_active IP Right Cessation
- 1979-07-03 DK DK280979A patent/DK155714C/da not_active IP Right Cessation
- 1979-07-03 NZ NZ190907A patent/NZ190907A/xx unknown
- 1979-07-03 AR AR277172A patent/AR222337A1/es active
- 1979-07-03 DE DE2926850A patent/DE2926850C2/de not_active Expired
- 1979-07-03 PT PT69869A patent/PT69869A/pt unknown
- 1979-07-03 KR KR1019790002214A patent/KR830001643B1/ko not_active IP Right Cessation
- 1979-07-03 CA CA331,006A patent/CA1132901A/en not_active Expired
- 1979-07-03 SE SE7905830A patent/SE445971B/sv unknown
- 1979-07-03 AU AU48615/79A patent/AU523295B2/en not_active Expired
- 1979-07-03 JP JP8356579A patent/JPS5531068A/ja active Granted
- 1979-07-03 US US06/054,440 patent/US4278654A/en not_active Expired - Lifetime
- 1979-07-03 AT AT0464479A patent/AT371998B/de not_active IP Right Cessation
- 1979-07-03 FR FR7917239A patent/FR2435253A1/fr active Granted
-
1981
- 1981-02-10 US US06/233,137 patent/US4396597A/en not_active Expired - Lifetime
-
1984
- 1984-01-21 SG SG57/84A patent/SG5784G/en unknown
- 1984-08-02 HK HK599/84A patent/HK59984A/xx not_active IP Right Cessation
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