FR2435253A1 - Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede - Google Patents
Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procedeInfo
- Publication number
- FR2435253A1 FR2435253A1 FR7917239A FR7917239A FR2435253A1 FR 2435253 A1 FR2435253 A1 FR 2435253A1 FR 7917239 A FR7917239 A FR 7917239A FR 7917239 A FR7917239 A FR 7917239A FR 2435253 A1 FR2435253 A1 FR 2435253A1
- Authority
- FR
- France
- Prior art keywords
- contrast substance
- rays
- preparation
- products obtained
- buffered solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Procédé de préparation d'une solution stérile physiologiquement acceptable et injectable d'une substance de contraste pour rayons X. Selon invention, on fait passer à l'autoclave une substance de contraste pour rayons X à groupe m-carbozamido-o-iodo-N-( beta -hydroxyalkyl)aniline, en présence d'un système tampon physiologiquement acceptable dont le pH diminue avec l'accroissement de la température. Dans ces conditions, aucune décomposition de la substance de contraste ne se produit
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7828764 | 1978-07-04 | ||
KR1019790002214A KR830001643B1 (ko) | 1978-07-04 | 1979-07-03 | X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2435253A1 true FR2435253A1 (fr) | 1980-04-04 |
FR2435253B1 FR2435253B1 (fr) | 1984-03-16 |
Family
ID=26268114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7917239A Granted FR2435253A1 (fr) | 1978-07-04 | 1979-07-03 | Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede |
Country Status (22)
Country | Link |
---|---|
US (2) | US4278654A (fr) |
JP (1) | JPS5531068A (fr) |
KR (1) | KR830001643B1 (fr) |
AR (1) | AR222337A1 (fr) |
AT (1) | AT371998B (fr) |
AU (1) | AU523295B2 (fr) |
BE (1) | BE877443A (fr) |
CA (1) | CA1132901A (fr) |
CH (1) | CH649469A5 (fr) |
DE (1) | DE2926850C2 (fr) |
DK (1) | DK155714C (fr) |
ES (1) | ES482131A0 (fr) |
FI (1) | FI75492C (fr) |
FR (1) | FR2435253A1 (fr) |
HK (1) | HK59984A (fr) |
IT (1) | IT1193761B (fr) |
NL (1) | NL183121C (fr) |
NZ (1) | NZ190907A (fr) |
PT (1) | PT69869A (fr) |
SE (1) | SE445971B (fr) |
SG (1) | SG5784G (fr) |
ZA (1) | ZA793313B (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0406992A2 (fr) * | 1989-07-05 | 1991-01-09 | Schering Aktiengesellschaft | Nouvel agent de contraste carboxamidique non ionique |
WO1992018168A1 (fr) * | 1991-04-12 | 1992-10-29 | Fresenius Ag | Emulsions huile dans l'eau d'un agent de contraste radiographique pouvant etre administrees par voie parenterale et thermo-sterilisables |
WO1997026862A2 (fr) * | 1996-01-25 | 1997-07-31 | Schering Aktiengesellschaft | Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
DE3689330T2 (de) * | 1985-08-09 | 1994-05-19 | Cook Imaging Corp | Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln. |
US5035877A (en) * | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
US4718463A (en) * | 1985-12-20 | 1988-01-12 | Mallinckrodt, Inc. | Method of producing prefilled sterile plastic syringes |
US5847009A (en) | 1986-01-14 | 1998-12-08 | Alliance Pharmaceutical Corp. | Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
US4863714A (en) * | 1987-02-05 | 1989-09-05 | Cook Imaging Corporation | Sterilization of compositions of limited stability |
US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
US5169864A (en) * | 1991-11-15 | 1992-12-08 | Baxter International Inc. | Unbuffered premixed ranitidine formulation |
DE4316722A1 (de) * | 1993-05-19 | 1994-11-24 | Fresenius Ag | Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels |
DE19648650C2 (de) * | 1996-01-29 | 1998-07-02 | Schering Ag | Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung |
US6072069A (en) * | 1998-11-04 | 2000-06-06 | Biophysica, Inc. | Biodegradable nonionic contrast media |
US7250153B2 (en) * | 2002-12-12 | 2007-07-31 | Biophysica Research, Inc. | Contrast media formulations having improved biological tolerance |
JP5947784B2 (ja) * | 2010-03-23 | 2016-07-06 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 安定化x線診断用組成物の製法 |
WO2013180777A1 (fr) * | 2012-05-30 | 2013-12-05 | Verrow Pharmaceuticals, Inc. | Formulations stabilisées contenant des agents de contraste iodés et des cyclodextrines |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3758E (fr) * | 1905-02-21 | Jules Cesar Napoleon Fouilloy | Collier d'attache pour protecteur antidérapant de pneumatiques | |
NL127881C (fr) * | 1963-03-25 | |||
GB1069437A (en) * | 1963-10-23 | 1967-05-17 | Nyegaard & Co As | Injectable x-ray contrast media |
US3733397A (en) * | 1966-12-02 | 1973-05-15 | Pharmacia Ab | Method for the x-ray visualization of body cavities and a preparation for carrying out the method |
SE315975B (fr) * | 1967-12-28 | 1969-10-13 | Pharmacia Ab | |
GB1321591A (en) * | 1969-06-27 | 1973-06-27 | Nyegaard & Co As | Non-ionic iodinated x-ray contrast agents |
US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
CH583562A5 (fr) * | 1973-07-17 | 1977-01-14 | Bracco Ind Chimica Spa | |
GB1495679A (en) * | 1974-06-17 | 1977-12-21 | Mallinckrodt Inc | Substituted isophthalamic acids |
US3953497A (en) * | 1974-07-29 | 1976-04-27 | Mallinckrodt, Inc. | 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof |
GB1514920A (en) * | 1974-10-09 | 1978-06-21 | Reckitt & Colmann Prod Ltd | Dispensing container for medicinal foams |
FI760068A (fr) * | 1975-02-03 | 1976-08-04 | Schering Ag | |
DE2505218A1 (de) * | 1975-02-05 | 1976-08-19 | Schering Ag | Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung |
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE2629228C2 (de) * | 1976-06-25 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung |
US4256729A (en) * | 1979-03-23 | 1981-03-17 | Mallinckrodt, Inc. | N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same |
-
1979
- 1979-07-03 CH CH6221/79A patent/CH649469A5/de not_active IP Right Cessation
- 1979-07-03 NL NLAANVRAGE7905166,A patent/NL183121C/xx not_active IP Right Cessation
- 1979-07-03 FI FI792101A patent/FI75492C/fi not_active IP Right Cessation
- 1979-07-03 IT IT49618/79A patent/IT1193761B/it active
- 1979-07-03 ES ES482131A patent/ES482131A0/es active Granted
- 1979-07-03 ZA ZA793313A patent/ZA793313B/xx unknown
- 1979-07-03 BE BE0/196098A patent/BE877443A/fr not_active IP Right Cessation
- 1979-07-03 DK DK280979A patent/DK155714C/da not_active IP Right Cessation
- 1979-07-03 NZ NZ190907A patent/NZ190907A/xx unknown
- 1979-07-03 AR AR277172A patent/AR222337A1/es active
- 1979-07-03 DE DE2926850A patent/DE2926850C2/de not_active Expired
- 1979-07-03 PT PT69869A patent/PT69869A/pt unknown
- 1979-07-03 KR KR1019790002214A patent/KR830001643B1/ko not_active IP Right Cessation
- 1979-07-03 CA CA331,006A patent/CA1132901A/fr not_active Expired
- 1979-07-03 SE SE7905830A patent/SE445971B/sv unknown
- 1979-07-03 AU AU48615/79A patent/AU523295B2/en not_active Expired
- 1979-07-03 JP JP8356579A patent/JPS5531068A/ja active Granted
- 1979-07-03 US US06/054,440 patent/US4278654A/en not_active Expired - Lifetime
- 1979-07-03 AT AT0464479A patent/AT371998B/de not_active IP Right Cessation
- 1979-07-03 FR FR7917239A patent/FR2435253A1/fr active Granted
-
1981
- 1981-02-10 US US06/233,137 patent/US4396597A/en not_active Expired - Lifetime
-
1984
- 1984-01-21 SG SG57/84A patent/SG5784G/en unknown
- 1984-08-02 HK HK599/84A patent/HK59984A/xx not_active IP Right Cessation
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0406992A2 (fr) * | 1989-07-05 | 1991-01-09 | Schering Aktiengesellschaft | Nouvel agent de contraste carboxamidique non ionique |
EP0406992A3 (en) * | 1989-07-05 | 1991-09-18 | Schering Aktiengesellschaft Berlin Und Bergkamen | New non-ionic carboxamide contrast agent |
WO1992018168A1 (fr) * | 1991-04-12 | 1992-10-29 | Fresenius Ag | Emulsions huile dans l'eau d'un agent de contraste radiographique pouvant etre administrees par voie parenterale et thermo-sterilisables |
WO1997026862A2 (fr) * | 1996-01-25 | 1997-07-31 | Schering Aktiengesellschaft | Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse |
WO1997026862A3 (fr) * | 1996-01-25 | 1997-10-23 | Schering Ag | Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse |
US6638913B1 (en) | 1996-01-25 | 2003-10-28 | Schering Aktiengesellschaft | Concentrated injection and infusion solution for intravenous administration |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0465, 920619 |
|
CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0465, 790703 |
|
CL | Concession to grant licences | ||
CD | Change of name or company name |