FR2435253A1 - Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede - Google Patents

Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede

Info

Publication number
FR2435253A1
FR2435253A1 FR7917239A FR7917239A FR2435253A1 FR 2435253 A1 FR2435253 A1 FR 2435253A1 FR 7917239 A FR7917239 A FR 7917239A FR 7917239 A FR7917239 A FR 7917239A FR 2435253 A1 FR2435253 A1 FR 2435253A1
Authority
FR
France
Prior art keywords
contrast substance
rays
preparation
products obtained
buffered solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7917239A
Other languages
English (en)
Other versions
FR2435253B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Publication of FR2435253A1 publication Critical patent/FR2435253A1/fr
Application granted granted Critical
Publication of FR2435253B1 publication Critical patent/FR2435253B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procédé de préparation d'une solution stérile physiologiquement acceptable et injectable d'une substance de contraste pour rayons X. Selon invention, on fait passer à l'autoclave une substance de contraste pour rayons X à groupe m-carbozamido-o-iodo-N-( beta -hydroxyalkyl)aniline, en présence d'un système tampon physiologiquement acceptable dont le pH diminue avec l'accroissement de la température. Dans ces conditions, aucune décomposition de la substance de contraste ne se produit
FR7917239A 1978-07-04 1979-07-03 Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede Granted FR2435253A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7828764 1978-07-04
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법

Publications (2)

Publication Number Publication Date
FR2435253A1 true FR2435253A1 (fr) 1980-04-04
FR2435253B1 FR2435253B1 (fr) 1984-03-16

Family

ID=26268114

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7917239A Granted FR2435253A1 (fr) 1978-07-04 1979-07-03 Procede de preparation d'une solution tamponnee d'une substance de contraste pour rayons x, et produits obtenus par ce procede

Country Status (22)

Country Link
US (2) US4278654A (fr)
JP (1) JPS5531068A (fr)
KR (1) KR830001643B1 (fr)
AR (1) AR222337A1 (fr)
AT (1) AT371998B (fr)
AU (1) AU523295B2 (fr)
BE (1) BE877443A (fr)
CA (1) CA1132901A (fr)
CH (1) CH649469A5 (fr)
DE (1) DE2926850C2 (fr)
DK (1) DK155714C (fr)
ES (1) ES482131A0 (fr)
FI (1) FI75492C (fr)
FR (1) FR2435253A1 (fr)
HK (1) HK59984A (fr)
IT (1) IT1193761B (fr)
NL (1) NL183121C (fr)
NZ (1) NZ190907A (fr)
PT (1) PT69869A (fr)
SE (1) SE445971B (fr)
SG (1) SG5784G (fr)
ZA (1) ZA793313B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406992A2 (fr) * 1989-07-05 1991-01-09 Schering Aktiengesellschaft Nouvel agent de contraste carboxamidique non ionique
WO1992018168A1 (fr) * 1991-04-12 1992-10-29 Fresenius Ag Emulsions huile dans l'eau d'un agent de contraste radiographique pouvant etre administrees par voie parenterale et thermo-sterilisables
WO1997026862A2 (fr) * 1996-01-25 1997-07-31 Schering Aktiengesellschaft Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
US4718463A (en) * 1985-12-20 1988-01-12 Mallinckrodt, Inc. Method of producing prefilled sterile plastic syringes
US5847009A (en) 1986-01-14 1998-12-08 Alliance Pharmaceutical Corp. Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
US4863714A (en) * 1987-02-05 1989-09-05 Cook Imaging Corporation Sterilization of compositions of limited stability
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
DE4316722A1 (de) * 1993-05-19 1994-11-24 Fresenius Ag Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels
DE19648650C2 (de) * 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
JP5947784B2 (ja) * 2010-03-23 2016-07-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 安定化ｘ線診断用組成物の製法
WO2013180777A1 (fr) * 2012-05-30 2013-12-05 Verrow Pharmaceuticals, Inc. Formulations stabilisées contenant des agents de contraste iodés et des cyclodextrines

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3758E (fr) * 1905-02-21 Jules Cesar Napoleon Fouilloy Collier d'attache pour protecteur antidérapant de pneumatiques
NL127881C (fr) * 1963-03-25
GB1069437A (en) * 1963-10-23 1967-05-17 Nyegaard & Co As Injectable x-ray contrast media
US3733397A (en) * 1966-12-02 1973-05-15 Pharmacia Ab Method for the x-ray visualization of body cavities and a preparation for carrying out the method
SE315975B (fr) * 1967-12-28 1969-10-13 Pharmacia Ab
GB1321591A (en) * 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
CH583562A5 (fr) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
US3953497A (en) * 1974-07-29 1976-04-27 Mallinckrodt, Inc. 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof
GB1514920A (en) * 1974-10-09 1978-06-21 Reckitt & Colmann Prod Ltd Dispensing container for medicinal foams
FI760068A (fr) * 1975-02-03 1976-08-04 Schering Ag
DE2505218A1 (de) * 1975-02-05 1976-08-19 Schering Ag Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406992A2 (fr) * 1989-07-05 1991-01-09 Schering Aktiengesellschaft Nouvel agent de contraste carboxamidique non ionique
EP0406992A3 (en) * 1989-07-05 1991-09-18 Schering Aktiengesellschaft Berlin Und Bergkamen New non-ionic carboxamide contrast agent
WO1992018168A1 (fr) * 1991-04-12 1992-10-29 Fresenius Ag Emulsions huile dans l'eau d'un agent de contraste radiographique pouvant etre administrees par voie parenterale et thermo-sterilisables
WO1997026862A2 (fr) * 1996-01-25 1997-07-31 Schering Aktiengesellschaft Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse
WO1997026862A3 (fr) * 1996-01-25 1997-10-23 Schering Ag Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse
US6638913B1 (en) 1996-01-25 2003-10-28 Schering Aktiengesellschaft Concentrated injection and infusion solution for intravenous administration

Also Published As

Publication number Publication date
US4396597A (en) 1983-08-02
ATA464479A (de) 1983-01-15
IT7949618A0 (it) 1979-07-03
NZ190907A (en) 1981-10-19
JPS6210209B2 (fr) 1987-03-05
JPS5531068A (en) 1980-03-05
DE2926850A1 (de) 1980-03-06
CA1132901A (fr) 1982-10-05
SG5784G (en) 1985-02-01
SE7905830L (sv) 1980-01-05
ZA793313B (en) 1980-08-27
HK59984A (en) 1984-08-10
AR222337A1 (es) 1981-05-15
FR2435253B1 (fr) 1984-03-16
DK155714C (da) 1989-10-30
NL183121C (nl) 1988-08-01
NL7905166A (nl) 1980-01-08
US4278654A (en) 1981-07-14
KR830000911A (ko) 1983-04-28
ES8200082A1 (es) 1980-12-16
FI792101A (fi) 1980-01-05
ES482131A0 (es) 1980-12-16
KR830001643B1 (ko) 1983-08-22
FI75492C (fi) 1988-07-11
DK280979A (da) 1980-01-05
CH649469A5 (de) 1985-05-31
SE445971B (sv) 1986-08-04
DK155714B (da) 1989-05-08
IT1193761B (it) 1988-08-24
BE877443A (fr) 1980-01-03
PT69869A (en) 1979-08-01
AU523295B2 (en) 1982-07-22
NL183121B (nl) 1988-03-01
DE2926850C2 (de) 1985-01-24
AT371998B (de) 1983-08-25
AU4861579A (en) 1980-02-07
FI75492B (fi) 1988-03-31

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Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0465, 920619

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0465, 790703

CL Concession to grant licences
CD Change of name or company name