KR20210035092A - 간 재생 촉진, 또는 간세포 사멸의 감소 또는 예방용 단백질 키나제 억제제 - Google Patents

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Publication number

KR20210035092A

KR20210035092A KR1020207036713A KR20207036713A KR20210035092A KR 20210035092 A KR20210035092 A KR 20210035092A KR 1020207036713 A KR1020207036713 A KR 1020207036713A KR 20207036713 A KR20207036713 A KR 20207036713A KR 20210035092 A KR20210035092 A KR 20210035092A

Authority

KR

South Korea

Prior art keywords

pyrrolo

pyridin

carbonyl

sulfonamide

phenyl

Prior art date

2018-07-16

Links

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• 101000624594 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Proteins 0.000 claims abstract description 18
• 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 claims abstract description 6
• -1 2H-tetrazolyl Chemical group 0.000 claims description 427
• 125000000217 alkyl group Chemical group 0.000 claims description 185
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• 150000002367 halogens Chemical class 0.000 claims description 78
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• 239000000203 mixture Substances 0.000 claims description 67
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 59
• 125000001072 heteroaryl group Chemical group 0.000 claims description 55
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• 125000005842 heteroatom Chemical group 0.000 claims description 52
• 125000003545 alkoxy group Chemical group 0.000 claims description 50
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 50
• 229910052760 oxygen Inorganic materials 0.000 claims description 49
• 238000000034 method Methods 0.000 claims description 37
• 229910052717 sulfur Inorganic materials 0.000 claims description 37
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• DROIHSMGGKKIJT-UHFFFAOYSA-N propane-1-sulfonamide Chemical compound CCCS(N)(=O)=O DROIHSMGGKKIJT-UHFFFAOYSA-N 0.000 claims description 27
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• 125000003342 alkenyl group Chemical group 0.000 claims description 12
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• CIORWBWIBBPXCG-SXZCQOKQSA-N alpha-amanitin Chemical compound O=C1N[C@@H](CC(N)=O)C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H]([C@@H](C)[C@@H](O)CO)C(=O)N[C@@H](C2)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@H]1C[S@@](=O)C1=C2C2=CC=C(O)C=C2N1 CIORWBWIBBPXCG-SXZCQOKQSA-N 0.000 claims description 4
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• YLOVOCUPQHQCLM-UHFFFAOYSA-N N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2-cyanophenyl]propane-1-sulfonamide Chemical compound ClC1=CC=C(C=C1)C=1C=C2C(=NC=1)NC=C2C(=O)C=1C(=C(C=CC=1)NS(=O)(=O)CCC)C#N YLOVOCUPQHQCLM-UHFFFAOYSA-N 0.000 claims description 2
• YBTGZIGLXHMBAC-UHFFFAOYSA-N N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2-fluorophenyl]-1-phenylmethanesulfonamide Chemical compound ClC1=CC=C(C=C1)C=1C=C2C(=NC=1)NC=C2C(=O)C=1C(=C(C=CC=1)NS(=O)(=O)CC1=CC=CC=C1)F YBTGZIGLXHMBAC-UHFFFAOYSA-N 0.000 claims description 2
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• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
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• 208000017667 Chronic Disease Diseases 0.000 claims 1
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