KR20080069715A - 불포화 지방산 함유 유지의 제조방법 - Google Patents
불포화 지방산 함유 유지의 제조방법 Download PDFInfo
- Publication number
- KR20080069715A KR20080069715A KR1020087015951A KR20087015951A KR20080069715A KR 20080069715 A KR20080069715 A KR 20080069715A KR 1020087015951 A KR1020087015951 A KR 1020087015951A KR 20087015951 A KR20087015951 A KR 20087015951A KR 20080069715 A KR20080069715 A KR 20080069715A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- arachidonic acid
- culture
- oil
- fat
- Prior art date
Links
- 235000021122 unsaturated fatty acids Nutrition 0.000 title claims abstract description 34
- 150000004670 unsaturated fatty acids Chemical class 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 42
- 241000235575 Mortierella Species 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 25
- 244000068988 Glycine max Species 0.000 claims abstract description 24
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 21
- 244000005700 microbiome Species 0.000 claims abstract description 19
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 90
- 239000003921 oil Substances 0.000 claims description 63
- 239000003925 fat Substances 0.000 claims description 61
- 235000019197 fats Nutrition 0.000 claims description 61
- 235000021342 arachidonic acid Nutrition 0.000 claims description 45
- 229940114079 arachidonic acid Drugs 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 37
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 20
- 239000008103 glucose Substances 0.000 claims description 20
- 238000005273 aeration Methods 0.000 claims description 13
- 235000013350 formula milk Nutrition 0.000 claims description 12
- 238000012258 culturing Methods 0.000 claims description 11
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 9
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 9
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 7
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000001963 growth medium Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 5
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims description 4
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims description 4
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims description 4
- 229960002733 gamolenic acid Drugs 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 238000010306 acid treatment Methods 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000007385 chemical modification Methods 0.000 claims description 3
- 238000003505 heat denaturation Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005238 degreasing Methods 0.000 claims description 2
- 238000004925 denaturation Methods 0.000 claims description 2
- 230000036425 denaturation Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 230000008929 regeneration Effects 0.000 claims description 2
- 238000011069 regeneration method Methods 0.000 claims description 2
- 235000008452 baby food Nutrition 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 230000002028 premature Effects 0.000 claims 3
- 239000000470 constituent Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 description 48
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 24
- BDCFUHIWJODVNG-UHFFFAOYSA-N Desmosterol Natural products C1C=C2CC(O)C=CC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 BDCFUHIWJODVNG-UHFFFAOYSA-N 0.000 description 17
- 229930182558 Sterol Natural products 0.000 description 17
- AVSXSVCZWQODGV-DPAQBDIFSA-N desmosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC=C(C)C)C)[C@@]1(C)CC2 AVSXSVCZWQODGV-DPAQBDIFSA-N 0.000 description 17
- 150000003432 sterols Chemical class 0.000 description 17
- 235000003702 sterols Nutrition 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 13
- 229930195729 fatty acid Natural products 0.000 description 13
- 239000000194 fatty acid Substances 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000306 component Substances 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- 241000907999 Mortierella alpina Species 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 11
- 238000000605 extraction Methods 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 241001219224 Mortierella elongata Species 0.000 description 4
- 108010073771 Soybean Proteins Proteins 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 4
- 229940041514 candida albicans extract Drugs 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 210000004748 cultured cell Anatomy 0.000 description 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 4
- -1 for example Chemical class 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 235000020256 human milk Nutrition 0.000 description 4
- 210000004251 human milk Anatomy 0.000 description 4
- 229960004488 linolenic acid Drugs 0.000 description 4
- 239000012533 medium component Substances 0.000 description 4
- 235000019710 soybean protein Nutrition 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 239000012138 yeast extract Substances 0.000 description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 235000019484 Rapeseed oil Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- 235000020778 linoleic acid Nutrition 0.000 description 3
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 235000014593 oils and fats Nutrition 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 235000012424 soybean oil Nutrition 0.000 description 3
- 239000003549 soybean oil Substances 0.000 description 3
- 150000003626 triacylglycerols Chemical group 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 235000021353 Lignoceric acid Nutrition 0.000 description 2
- CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 241000133355 Mortierella hygrophila Species 0.000 description 2
- 235000021360 Myristic acid Nutrition 0.000 description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 2
- 235000019797 dipotassium phosphate Nutrition 0.000 description 2
- 229940090949 docosahexaenoic acid Drugs 0.000 description 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 2
- 235000004626 essential fatty acids Nutrition 0.000 description 2
- FARYTWBWLZAXNK-WAYWQWQTSA-N ethyl (z)-3-(methylamino)but-2-enoate Chemical compound CCOC(=O)\C=C(\C)NC FARYTWBWLZAXNK-WAYWQWQTSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 2
- 150000002617 leukotrienes Chemical class 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical compound CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Chemical group NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000048020 Mortierella exigua Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000004641 brain development Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- SIHHLZPXQLFPMC-UHFFFAOYSA-N chloroform;methanol;hydrate Chemical compound O.OC.ClC(Cl)Cl SIHHLZPXQLFPMC-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 235000013681 dietary sucrose Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- 210000000754 myometrium Anatomy 0.000 description 1
- 229940038384 octadecane Drugs 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical group 0.000 description 1
- 150000003905 phosphatidylinositols Chemical group 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/801—Pediatric
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/807—Poultry or ruminant feed
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Animal Husbandry (AREA)
- Pediatric Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Fodder In General (AREA)
Abstract
Description
24,25-메틸렌콜레스트-5-엔-3β-올 조성비(A) | 데스모스테롤 조성비(B) | A/B | 총 스테롤 양* | 아라키돈산 함량** | |
실시예 | 30% | 65% | 0.46 | 1% | 8% |
비교예 | 65% | 27% | 2.41 | 1% | 9% |
* 유지 중의 스테롤 함량 ** 유지 중의 전체 지방산에 대한 아라키돈산의 함유율 |
24,25-메틸렌콜레스트-5-엔-3β-올 조성비(A) | 데스모스테롤 조성비(B) | A/B | 총 스테롤 양* | 아라키돈산 함량** | |
실시예 | 25% | 53% | 0.47 | 1.2% | 48% |
비교예 | 68% | 16% | 4.25 | 1.1% | 46% |
* 유지 중의 스테롤 함량 ** 유지 중의 전체 지방산에 대한 아라키돈산의 함유율 |
24,25-메틸렌콜레스트 -5-엔-3β-올 조성비(A) | 데스모스테롤 조성비(B) | A/B | 총 스테롤 양* | 아라키돈산 함량** | |
모르티에렐라 알피나 ATCC32221 | 5% | 67% | 0.07 | 0.9% | 25% |
비교예 | 37% | 28% | 1.32 | 0.8% | 20% |
모르티에렐라 알피나 ATCC42430 | 5% | 35% | 0.14 | 0.9% | 18% |
비교예 | 40% | 25% | 1.60 | 1.0% | 18% |
* 유지 중의 스테롤 함량 ** 유지 중의 전체 지방산에 대한 아라키돈산의 함유율 |
Claims (23)
- 모르티에렐라(Mortierella) 속 모르티에렐라 아속에 속하는 미생물을 통기 배양조에서 탈지 대두, 또는 물리적 또는 화학적으로 가공한 탈지 대두로부터 수득된 질소원(窒素源)을 함유하는 배지에서 배양하여 당해 배양물로부터 불포화 지방산-함유 유지를 채취함을 포함하는, 24,25-메틸렌콜레스트-5-엔-3β-올 조성비가 35% 이하인 불포화 지방산-함유 유지의 제조 방법.
- 제1항에 있어서, 탈지 대두로부터 수득된 질소원이 수분을 제외한 총 성분에 대하여 2중량% 이상의 질소 함량을 제공하는 방법.
- 제2항에 있어서, 질소원이 5중량% 이상의 질소 함량을 제공하는 방법.
- 제1항, 제2항 또는 제3항에 있어서, 질소원인 탈지 대두가 열 처리; 산 처리; 알칼리 처리; 효소 처리; 화학적 개질; 상기 처리를 포함하는 화학적 처리 및/또는 물리적 처리에 의한 변성 및/또는 재생; 물 및/또는 유기 용매를 사용한 일부 성분의 제거; 여과 및/또는 원심분리에 의한 일부 성분의 제거; 동결; 분쇄; 건조; 및/또는 체 분리에 의해 가공된 방법.
- 제1항, 제2항 또는 제3항에 있어서, 탈지 대두로부터 수득된 질소원이 탈지 대두에 적어도 열변성을 수행한 것인 방법.
- 제1항, 제2항 또는 제3항에 있어서, 배양물이 균체 배양함으로써 유지를 제조하는 도중의 배양액 또는 이를 살균한 배양액, 배양 종료시의 배양액 또는 이를 살균한 배양액, 또는 각각으로부터 집균한 배양 균체 또는 이의 건조물인 방법.
- 제1항, 제2항 또는 제3항에 있어서, 배양조가 교반기 및 통기 장치를 구비한 배양조 또는 에어-리프트 배양조인 방법.
- 제1항, 제2항 또는 제3항에 있어서, 배양이 배양 개시로부터 적어도 3일 동안, 글루코스의 농도가 0.3중량% 이상 및/또는 글루코스의 평균 농도가 0.5중량% 이상으로 되도록 유지되면서 수행되는 방법.
- 제1항, 제2항 또는 제3항에 있어서, 배양이 2 내지 20일의 기간 동안 수행되는 방법.
- 제1항, 제2항 또는 제3항에 있어서, 유지 중의 불포화 지방산이 γ-리놀렌산, 디호모-γ-리놀렌산, 아라키돈산, 에이코사펜타엔산 및/또는 미드산인 방법.
- 제10항에 있어서, 유지가 20 내지 54%의 아라키돈산을 함유하고 24,25-메틸 렌콜레스트-5-엔-3β-올 조성비가 35% 이하인 방법.
- 제11항에 따라 제조된 아라키돈산 함유 유지를 영양 보조 식품, 미숙아용 조제유, 유아용 조제유, 유아용 식품, 임산부용 식품 또는 동물용 사료에 배합함을 특징으로 하는 영양 보조 식품, 미숙아용 조제유, 유아용 조제유, 유아용 식품, 임산부용 식품 또는 동물용 사료의 제조 방법 .
- 20 내지 54%의 아라키돈산을 함유하고, 24,25-메틸렌콜레스트-5-엔-3β-올 조성비가 35% 이하인, 제1항, 제2항 또는 제3항에 따른 방법에 의해 수득할 수 있는 불포화 지방산-함유 유지.
- 24,25-메틸렌콜레스트-5-엔-3β-올 조성비가 35% 이하이고 아라키돈산 함량이 20 내지 54%이고, 모르티에렐라 속 모르티에렐라 아속에 속하는 미생물을 통기 배양조에서 배양함으로써 수득할 수 있음을 특징으로 하는, 아라키돈산-함유 유지.
- 제14항에 있어서, 배양이 대두로부터 유래된 질소원을 사용한, 아라키돈산-함유 유지.
- 제13항, 제14항 또는 제15항에 있어서, 24,25-메틸렌콜레스트-5-엔-3β-올 조성비가 데스모스테롤 조성비에 대하여 1.2 이하임을 특징으로 하는 아라키돈산- 함유 유지.
- 제13항, 제14항 또는 제15항에 따른 아라키돈산-함유 유지를 함유하는 영양 보조 식품.
- 제13항, 제14항 또는 제15항에 따른 아라키돈산-함유 유지를 함유하는 미숙아용 조제유, 유아용 조제유, 유아용 식품 또는 임산부용 식품.
- 제13항, 제14항 또는 제15항에 따른 아라키돈산-함유 유지를 함유하는 동물용 사료.
- 24,25-메틸렌콜레스트-5-엔-3β-올 조성비가 데스모스테롤 조성비에 대하여 1.2 이하이고 아라키돈산 함량이 20 내지 54%이며, 모르티에렐라 속 모르티에렐라 아속에 속하는 미생물로부터 수득할 수 있는 미생물성 유지인 아라키돈산-함유 유지.
- 제20항에 따른 아라키돈산-함유 유지를 함유하는 영양 보조 식품.
- 제20항에 따른 아라키돈산-함유 유지를 함유하는 미숙아용 조제유, 유아용 조제유, 유아용 식품 또는 임산부용 식품.
- 제20항에 따른 아라키돈산-함유 유지를 함유하는 동물용 사료.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-1996-00230210 | 1996-08-30 | ||
JP23021096A JP3792309B2 (ja) | 1996-08-30 | 1996-08-30 | 不飽和脂肪酸含有油脂の製造方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019997001593A Division KR20000035882A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조 방법 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020107013765A Division KR20100082380A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산-함유 유지 제조용 배지 |
KR1020097024014A Division KR101194595B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20080069715A true KR20080069715A (ko) | 2008-07-28 |
Family
ID=16904303
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020087015951A KR20080069715A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020127002359A KR20120047922A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020097024014A KR101194595B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020137034734A KR101391880B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020147002206A KR101475711B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1019997001593A KR20000035882A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조 방법 |
KR1020147005042A KR101475713B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020107013765A KR20100082380A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산-함유 유지 제조용 배지 |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020127002359A KR20120047922A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020097024014A KR101194595B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020137034734A KR101391880B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020147002206A KR101475711B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1019997001593A KR20000035882A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조 방법 |
KR1020147005042A KR101475713B1 (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산 함유 유지의 제조방법 |
KR1020107013765A KR20100082380A (ko) | 1996-08-30 | 1997-08-27 | 불포화 지방산-함유 유지 제조용 배지 |
Country Status (13)
Country | Link |
---|---|
US (4) | US7091244B1 (ko) |
EP (2) | EP1454990B2 (ko) |
JP (1) | JP3792309B2 (ko) |
KR (8) | KR20080069715A (ko) |
CN (4) | CN1200109C (ko) |
AT (2) | ATE277195T2 (ko) |
AU (1) | AU759623C (ko) |
CA (1) | CA2264276C (ko) |
DE (2) | DE69730867T3 (ko) |
DK (2) | DK1454990T4 (ko) |
ES (2) | ES2255017T5 (ko) |
PT (2) | PT1454990E (ko) |
WO (1) | WO1998008967A1 (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3792309B2 (ja) | 1996-08-30 | 2006-07-05 | サントリー株式会社 | 不飽和脂肪酸含有油脂の製造方法 |
BR9911234B1 (pt) * | 1998-06-17 | 2012-01-10 | ácido araquidÈnico (ara) microbiano para uso em alimentação marinha. | |
DE19836339B4 (de) | 1998-08-11 | 2011-12-22 | N.V. Nutricia | Kohlenhydratmischung |
US6403349B1 (en) * | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
CA2653503A1 (en) * | 1998-10-15 | 2000-04-20 | Dsm Ip Assets B.V. | The use of ara as a supplement for a lactating woman |
KR20010010268A (ko) * | 1999-07-19 | 2001-02-05 | 유병택 | 아라키돈산이 강화된 사료 조성물 |
US7070970B2 (en) | 1999-08-23 | 2006-07-04 | Abbott Laboratories | Elongase genes and uses thereof |
KR20020073580A (ko) * | 2000-02-09 | 2002-09-27 | 바스프 악티엔게젤샤프트 | 신규 연장효소 유전자 및 다가불포화 지방산의 제조 방법 |
US6596302B2 (en) | 2000-04-13 | 2003-07-22 | Abbott Laboratories | Infant formulas containing long-chain polyunsaturated fatty acids and uses thereof |
WO2003017945A2 (en) | 2001-08-24 | 2003-03-06 | Martek Biosciences Boulder Corporation | Products containing highly unsaturated fatty acids for use by women and their children during stages of preconception, pregnancy and lactation/post-partum |
JP3729272B2 (ja) * | 2002-05-14 | 2005-12-21 | 株式会社J−オイルミルズ | 長鎖高度不飽和脂肪酸及び/又はそのエステル体から成るコク味向上剤、及びこれを含む植物油脂組成物 |
KR20050013584A (ko) * | 2002-06-19 | 2005-02-04 | 디에스엠 아이피 어셋츠 비.브이. | 미생물세포와 미생물 오일용 파스퇴르살균 방법 |
SI2267142T1 (sl) * | 2002-10-11 | 2015-12-31 | Nippon Suisan Kaisha, Ltd. | Postopek izdelave mikrobne maščobe ali olja, z znižano vsebnostjo snovi, ki jih ni mogoče saponificirati in omenjeno maščobo ali olje |
AU2004255070B2 (en) * | 2003-07-09 | 2009-06-25 | J-Oil Mills, Inc. | Full-bodied taste enhancer containing product of decomposition of long-chain highly unsaturated fatty acid or containing extract therefrom |
TW201119585A (en) * | 2003-11-12 | 2011-06-16 | J Oil Mills Inc | Body taste improver comprising long-chain highly unsaturated fatty acid and/or its ester |
TW200526131A (en) * | 2003-11-12 | 2005-08-16 | J Oil Mills Inc | Method of application of body taste enhancer comprising long-chain highly unsaturated fatty acid and/or its ester |
EP1597978A1 (en) | 2004-05-17 | 2005-11-23 | Nutricia N.V. | Synergism of GOS and polyfructose |
US8252769B2 (en) | 2004-06-22 | 2012-08-28 | N. V. Nutricia | Intestinal barrier integrity |
DK1758469T4 (da) * | 2004-06-22 | 2013-11-04 | Nutricia Nv | Forbedring af barriereintegriteten hos HIV-patienter ved anvendelse af fedtsyrer |
JP4624040B2 (ja) * | 2004-09-06 | 2011-02-02 | 日本水産株式会社 | 菌体培養方法 |
US7588931B2 (en) * | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
JP2009284859A (ja) * | 2008-05-30 | 2009-12-10 | J-Oil Mills Inc | 飲食品の甘味増強剤および甘味増強方法 |
LT2493325T (lt) * | 2009-10-28 | 2021-04-26 | Valio Ltd | Išrūgų baltymų produktas ir jo paruošimo būdas |
JP5416861B2 (ja) * | 2011-03-03 | 2014-02-12 | 日本水産株式会社 | リパーゼによる高度不飽和脂肪酸含有油脂の製造方法 |
EP2734197A4 (en) * | 2011-07-21 | 2014-12-17 | Dsm Ip Assets Bv | FATTY ACID COMPOSITIONS |
EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
WO2016050556A1 (de) | 2014-10-02 | 2016-04-07 | Evonik Degussa Gmbh | Verfahren zur anzucht von tieren |
US11464244B2 (en) | 2014-10-02 | 2022-10-11 | Evonik Operations Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
BR112017006838B1 (pt) | 2014-10-02 | 2021-07-06 | Evonik Operations Gmbh | Processo para produzir um alimento para animais compreendendo biomassa contendo pufa, alimento para animais e método para criar animais |
BR112017006834B1 (pt) | 2014-10-02 | 2022-04-26 | Evonik Operations Gmbh | Processo para a preparação de um alimento para animais compreendendo pufas, produto extrudado de alimento para animais e método de criação de animais |
CN109266698B (zh) * | 2018-05-17 | 2022-10-28 | 梁云 | 被孢霉属微生物油脂中脂肪酸组合物成分调整的方法 |
CN117730810A (zh) * | 2024-01-24 | 2024-03-22 | 广东海洋大学 | 橄榄油在提高东风螺幼虫***率和/或存活率中的应用 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155420B1 (en) | 1984-02-09 | 1988-03-23 | The Agency of Industrial Science and Technology | A method for the preparation of a fungal body and a lipid rich in gamma-linolenic acid therefrom |
JPH0716424B2 (ja) | 1985-10-01 | 1995-03-01 | ライオン株式会社 | アラキドン酸含有脂質の製造方法 |
JPH0734752B2 (ja) | 1986-03-31 | 1995-04-19 | サントリー株式会社 | アラキドン酸及びこれを含有する脂質の製造方法 |
US5204250A (en) | 1986-03-31 | 1993-04-20 | Suntory Limited | Process for production of arachidonic acid |
CA1317901C (en) | 1986-07-08 | 1993-05-18 | Yoshifumi Shinmen | Process for production of bishomo-_-linolenic acid and eicosapentaenoic acid |
JPS63116643A (ja) | 1986-11-04 | 1988-05-20 | Kazumitsu Maruta | γ―リノレン酸含有食用組成物 |
JPS63133994A (ja) | 1986-11-21 | 1988-06-06 | Lion Corp | γ−リノレン酸を含有する脂質の製造方法 |
JPS63133944A (ja) | 1986-11-25 | 1988-06-06 | Kawanishi Shoji:Kk | 生あんの保存方法 |
JP2520118B2 (ja) | 1986-12-09 | 1996-07-31 | 株式会社 ニホンゲンマ | クリ−ムはんだ |
ATE87332T1 (de) * | 1987-01-28 | 1993-04-15 | Suntory Ltd | Verfahren zur herstellung von arachidonsaeure. |
JPS6438007A (en) | 1987-04-28 | 1989-02-08 | Lion Corp | Skin external preparation |
JP2697834B2 (ja) | 1988-02-02 | 1998-01-14 | サントリー株式会社 | 高度不飽和脂肪酸成分添加人工乳 |
JPH01304892A (ja) | 1988-02-03 | 1989-12-08 | Suntory Ltd | 高度不飽和脂肪酸強化油脂の製造方法 |
JP2723243B2 (ja) | 1988-02-25 | 1998-03-09 | サントリー株式会社 | 高度不飽和脂肪酸添加動物飼料 |
US5093249A (en) | 1989-05-24 | 1992-03-03 | Idemitsu Petrochemical Co., Ltd. | Process for production of dihomo-γ-linolenic acid and inhibitor for unsaturation reaction at Δ5-position of fatty acid |
JP2958361B2 (ja) | 1989-05-24 | 1999-10-06 | 出光石油化学株式会社 | ジホモ―γ―リノレン酸の製造法および脂肪酸の△5位不飽和化反応抑制剤 |
GB9002048D0 (en) | 1990-01-30 | 1990-03-28 | Efamol Holdings | Essential fatty acid compositions and treatments |
US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
JP2944132B2 (ja) | 1990-03-23 | 1999-08-30 | サントリー株式会社 | 新規高度不飽和脂肪酸並びに該脂肪酸又はこれを含有する脂質の製造方法 |
PH11992043811B1 (en) * | 1991-01-24 | 2002-08-22 | Martek Corp | Arachidonic acid and methods for the production and use thereof |
US5658767A (en) † | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
DE69210892T2 (de) | 1991-07-11 | 1996-10-02 | Idemitsu Petrochemical Co | Triglyceride enthaltende trockene Zellfragmente und Verfahren zu deren Herstellung |
JPH0517796A (ja) | 1991-07-11 | 1993-01-26 | Idemitsu Petrochem Co Ltd | トリグリセリドの回収方法 |
JPH05308979A (ja) | 1992-05-01 | 1993-11-22 | Idemitsu Petrochem Co Ltd | トリグリセリド含有乾燥菌体破砕物とその製造法 |
JP3354581B2 (ja) | 1991-09-30 | 2002-12-09 | サントリー株式会社 | ジホモ−γ−リノレン酸及びこれを含有する脂質の製造方法 |
JP3354582B2 (ja) * | 1991-09-30 | 2002-12-09 | サントリー株式会社 | オメガ9系高度不飽和脂肪酸およびこれを含有する脂質の製造方法 |
JPH06172263A (ja) | 1992-08-14 | 1994-06-21 | Agency Of Ind Science & Technol | 高純度アラキドン酸トリグリセリド及びその製造方法 |
US5487817A (en) * | 1993-02-11 | 1996-01-30 | Hoffmann-La Roche Inc. | Process for tocopherols and sterols from natural sources |
JPH0741421A (ja) * | 1993-05-28 | 1995-02-10 | Suntory Ltd | ロイコトリエンb4 (ltb4 )による医学的症状の予防及び改善剤 |
EP2140863A1 (en) * | 1993-06-09 | 2010-01-06 | Martek Biosciences Corporation | Use of docosahexaenoic acid for the manufacture of a medicament for the treatment of neurological disorders |
JP2677949B2 (ja) | 1993-08-26 | 1997-11-17 | 常盤薬品工業株式会社 | アラキドン酸含有健康食品 |
US5583019A (en) | 1995-01-24 | 1996-12-10 | Omegatech Inc. | Method for production of arachidonic acid |
ES2267137T5 (es) | 1996-03-28 | 2014-03-14 | Dsm Ip Assets B.V. | Aceite microbiano que contiene ácido graso poli-insaturado y método de producir aceite a partir de biomasa pasteurizada y granulada |
US6166230A (en) | 1996-05-15 | 2000-12-26 | Gist-Brocades B.V. | Sterol extraction with polar solvent to give low sterol, high triglyceride, microbial oil |
JP3792309B2 (ja) | 1996-08-30 | 2006-07-05 | サントリー株式会社 | 不飽和脂肪酸含有油脂の製造方法 |
JP4633204B2 (ja) * | 1996-10-11 | 2011-02-16 | サントリーホールディングス株式会社 | アラキドン酸含有食用油脂およびそれを含有する食品 |
-
1996
- 1996-08-30 JP JP23021096A patent/JP3792309B2/ja not_active Expired - Lifetime
-
1997
- 1997-08-27 DK DK04012292.1T patent/DK1454990T4/en active
- 1997-08-27 WO PCT/JP1997/002989 patent/WO1998008967A1/ja active IP Right Grant
- 1997-08-27 KR KR1020087015951A patent/KR20080069715A/ko not_active Application Discontinuation
- 1997-08-27 CN CNB971984034A patent/CN1200109C/zh not_active Expired - Lifetime
- 1997-08-27 CN CNB031587984A patent/CN100502675C/zh not_active Expired - Lifetime
- 1997-08-27 KR KR1020127002359A patent/KR20120047922A/ko not_active Application Discontinuation
- 1997-08-27 CA CA2264276A patent/CA2264276C/en not_active Expired - Lifetime
- 1997-08-27 ES ES04012292.1T patent/ES2255017T5/es not_active Expired - Lifetime
- 1997-08-27 CN CN200510022831XA patent/CN1806644B/zh not_active Expired - Lifetime
- 1997-08-27 ES ES97937813.0T patent/ES2224264T5/es not_active Expired - Lifetime
- 1997-08-27 PT PT04012292T patent/PT1454990E/pt unknown
- 1997-08-27 EP EP04012292.1A patent/EP1454990B2/en not_active Expired - Lifetime
- 1997-08-27 KR KR1020097024014A patent/KR101194595B1/ko active IP Right Grant
- 1997-08-27 EP EP97937813.0A patent/EP0957173B2/en not_active Expired - Lifetime
- 1997-08-27 AT AT97937813T patent/ATE277195T2/de active
- 1997-08-27 AT AT04012292T patent/ATE318323T2/de active
- 1997-08-27 KR KR1020137034734A patent/KR101391880B1/ko active IP Right Grant
- 1997-08-27 CN CN2007101598883A patent/CN101268828B/zh not_active Expired - Lifetime
- 1997-08-27 KR KR1020147002206A patent/KR101475711B1/ko active IP Right Grant
- 1997-08-27 KR KR1019997001593A patent/KR20000035882A/ko not_active Application Discontinuation
- 1997-08-27 DE DE69730867.7T patent/DE69730867T3/de not_active Expired - Lifetime
- 1997-08-27 DE DE69735278.1T patent/DE69735278T3/de not_active Expired - Lifetime
- 1997-08-27 DK DK97937813T patent/DK0957173T3/da active
- 1997-08-27 KR KR1020147005042A patent/KR101475713B1/ko active IP Right Grant
- 1997-08-27 PT PT97937813T patent/PT957173E/pt unknown
- 1997-08-27 KR KR1020107013765A patent/KR20100082380A/ko active Search and Examination
- 1997-08-27 US US09/254,152 patent/US7091244B1/en not_active Expired - Fee Related
-
2000
- 2000-08-04 AU AU200050537A patent/AU759623C/en not_active Expired - Fee Related
-
2005
- 2005-11-28 US US11/287,369 patent/US9464305B2/en not_active Expired - Lifetime
-
2006
- 2006-04-21 US US11/407,984 patent/US8841097B2/en not_active Expired - Fee Related
- 2006-07-10 US US11/482,901 patent/US9493798B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101194595B1 (ko) | 불포화 지방산 함유 유지의 제조방법 | |
KR101194236B1 (ko) | 장쇄 고도 불포화 지방산을 구성요소로서 포함하는 인지질 및 그 이용 | |
KR101451415B1 (ko) | 불비누화 물질 함량을 저감시킨 미생물 유지의 제조 방법 및 그 유지 | |
EP1537221B1 (en) | Process for production of transesterified oils/fats or triglycerides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A107 | Divisional application of patent | ||
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
N231 | Notification of change of applicant | ||
A107 | Divisional application of patent | ||
AMND | Amendment | ||
E601 | Decision to refuse application | ||
J201 | Request for trial against refusal decision | ||
A107 | Divisional application of patent | ||
AMND | Amendment | ||
B601 | Maintenance of original decision after re-examination before a trial | ||
J301 | Trial decision |
Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20100520 Effective date: 20110218 Free format text: TRIAL NUMBER: 2010101003673; TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20100520 Effective date: 20110218 |
|
J2X1 | Appeal (before the patent court) |
Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL Free format text: TRIAL NUMBER: 2011201002817; APPEAL AGAINST DECISION TO DECLINE REFUSAL |
|
J302 | Written judgement (patent court) |
Free format text: JUDGMENT (PATENT COURT) FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20110325 Effective date: 20111012 Free format text: TRIAL NUMBER: 2011201002817; JUDGMENT (PATENT COURT) FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20110325 Effective date: 20111012 |
|
WITB | Written withdrawal of application |