KR20050092658A - 모낭형성능력을 가지는 유전자 - Google Patents
모낭형성능력을 가지는 유전자 Download PDFInfo
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Abstract
본 발명은 계대배양을 한번도 하지 않은 상태의 모유두(dermal papilla) 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 모낭형성능력을 가진 유전자에 대한 발명이다.
Description
본 발명은 모낭형성능력을 가지는 유전자에 관한 발명으로 더욱 상세하게는 계대를 한번도 하지 않은 상태의 모유두 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 유전자에 관한 발명이다.
일반적으로 모낭의 발생 및 주기적 재생은 상피 및 간엽 세포군 간의 상호작용에 의하여 조절된다(Hardy, M.H. Trends Genet.
8: 55-61. (1992); Stenn, K.S., 등 Physiol Rev. 81(1):449-494 (2001)). 모낭에서 상피 및 간엽 세포들 간에는 서로 많은 근거리 신호들에 의해 상호작용하고, 몇 층으로 분화하여 모축(hair shaft), 근초(root sheaths) 및 모유두(dermal papilla)를 형성한다(Hardy, M.H. Trends Genet.
8: 55-61. (1992);Millar SE. J Invest Dermatol 2002 Feb;118(2):216-25 (2002)).
모낭에 있는 많은 세포군 중에서, 상피 모 초기세포(placode) 아래에 있는 응집된(condensed) 간엽세포에서 기원하고 모낭의 베이스에 위치한 모유두(dermal papilla;DP)는 모발(hair)의 발생, 성장 및 주기의 유지에 중요한 역할을 한다(Oliver RF, 등 Clin Dermatol. 6(4):74-82 (1988); Jahoda, CAB, 등 Nature, 311, 560-562 (1984)). 모발 주기에 대한 최근의 가설은 모낭의 다른 콤포넌트에 영향을 주는 조절인자의 생성을 변화시키는 모유두 세포에 작용하는 여러 조절인자가 관여한다는 것이다(Randall VA, 등 Ann. NY Acad. Sci., 642:355-375 (1991); Randall VA Clin. Endocrinol., 40:439-457 (1994)). 최근 연구는 모낭 발생의 초기 단계에서 fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), sonic hedgehog (Shh), 및 Wnt 계열 단백질(Millar SE. 등 J Invest Dermatol 2002 Feb;118(2):216-25 (2002) ;Jiro Kishimoto, 등 Gene & Development 14:1181-1185 (2000))과 같은 모 발생에 중요한 몇 신호물질을 밝혀냈다(Oro AE, 등 Cell. 1998 Nov 25;95(5):575-8). 그러나 피부 응집(condensation) 과정 또는 새로운 성장기(anagne) 모발 생성에 대한 시작 인자에서 직접적인 작용을 갖는 간엽에서 표적 유전자들에 대해서는 거의 알려져 있지 않다.
이식실험을 통하여 신선하게 잘라낸 모유두 세포는 피부아래에 이식되었을 때 모발 성장을 유도할 수 있다는 것을 보여 주었고(Oliver RF. 등 Embryol Exp Morphol Aug;18(1):43-51 (1967); Ibrahaim, 등 Nature, Lond. 265, 733-734. (1977)), 귀 또는 음낭 주머니 표피와 상호작용을 시키면 새로운 모낭의 발생을 유도한다는 것을 알 수 있었다(Oliver, R. F. J. Embryol. exp. Morph. 23, 219-236 (1970)). 모유두세포의 배양은 모낭의 형성을 이끄는 상피-간엽 상호작용의 메카니즘을 찾는 연구자들에게는 유용한 방법이다. 그러한 첫 번째 시도는 유두부에 대한 단일 형태학적 특성을 기술한 래트 수염 모유두(vibrissal papillae)에 대한 Jahoda 및 Oliver(Br J Dermatol 105:623-627 (1981))와 인간 모유두에 대한 Messenger(Br J Dermatol, 110, 685-689. (1984))에 의한 보고에서였다. 래트(Jahoda, 등 Nature, 311, 560-562 (1984)) 및 인간(Katsuoka, 등 In Vitro. Arch Dermatol Res, 279, 20-25, (1986); Messenger, 등 Br J Dermatol, 114, 425-430, (1986); Warren, 등 J Invest Dermatol, 98, 693-699, (1992); Warren, 등 Arch Dermatol Res, 286, 1-5 (1994))의 배양된 모유두세포의 성장능력에 대한 규명을 위한 몇 번의 시도가 있었다. Jahoda 등은 배양된 쥐수염 모유두세포에서 그들의 모발 유도 활성을 가지는 것을 처음으로 밝혔으나 배양에서 모유두세포는 계대 수가 증가하면 그들의 활성을 잃는다는 것이 알려졌다(Horne, KA, 등 J Embryol Exp Morph, 97, 111-124 (1986); Lichti, 등 J Invest Dermatol, 101, 124S-129S (1993); Weinberg, 등 J Invest Dermatol, 100, 229-236 (1993)). 단지 하나의 in vivo DP-특이적인 마커가 보고 되었다. Kishimoto 등은 버시칸(versican)은 in vivo DP 마커이고 버시칸을 발현하는 모유두세포는 모발 유도능을 갖는다고 보고하였다(Jiro Kishimoto, 등 PNAS Vol.96, pp. 7336-7341, June (1999)).
DNA 마이크로어레이는 한번의 실험으로 수천 개의 유전자들의 발현을 동시에 측정할 수 있는 포맷을 제공한다(Shalon D, 등 Genome Res., 6:639-645 (1996); Schena M, 등 Proc. Natl. Acad. Sci. USA, 93:10614-10619 (1996); Khan J, 등 Proc. Natl. Acad. Sci. USA, 96:13264-13269 (1999); Duggan DJ, 등 Nat. Genet., 21:10-14 (1999); Brown PO, 등 Nat. Genet., 21:33-37 (1999)). 그리고 그것은 이미 가슴 조직(Perou CM, 등 Proc. Natl. Acad. Sci., 96:9212-9217 (1999)), 멜라닌세포(Loftus SK, 등 Proc. Natl. Acad. Sci., 96:9277-9280 (1999)) 및 림프구(Alizadeh AA, 등 Nature, 403:503-511 (2000))와 같은 특정 연구분야에서 조직특이적인 DNA 마이크로어레이를 갖는다는 것은 매우 효율적이고 적당한 것이 될 것이다.
본 발명은 상기의 필요성에 의해 안출된 것으로 본 발명의 목적은 모낭 형성 능력을 갖는 유전자를 제공하는 것이다.
상기의 목적을 달성하기 위해 본 발명은 콜라겐형 VII(서열번호26), DNA 바인딩 3 저해제(서열번호27), 종양 엔도쎄리얼 마커 6(서열번호28), 사이토키네시스1의 단백질 조절자(서열번호 29), 염색체1q(ch 1q)의 올(ALL)1-융합된 유전자를 코딩하는 단백질(서열번호 30), 포크헤드 박스 M1(서열번호31), 가상(hypothetical) 단백질 FLJ10540(서열번호32), 감마-굴루타밀 하이드로레이즈(서열번호33), 가상 단백질 MGC5576(서열번호34), 프로테오리피드 단백질 2(서열번호35), 가상 단백질 DKFZp434B044(서열번호36), S-아데노실메티오닌 디카르복실레이즈 1(서열번호37), 프레이오트로핀(서열번호38), 알도-케토·리덕테이즈 B1(서열번호39), 신데칸 3(서열번호40), 메탈로프로테이즈 3 조직 인히비터(TIMP-3)(서열번호41), 스프로티 호모로지 4(서열번호42), 트랜스케토레이즈(서열번호43), FXYD 도메인 5(서열번호44), CD9 항원(p24)(서열번호45) 및 프로테오좀 액티베이터 단위체2(서열번호46), 가상 단백질 FLJ22009(서열번호47), SH3-도메인(서열번호48) 및 DKFZp434J214(서열번호49) 단백질로 구성된 군으로부터 선택된 하나의 모낭형성능력을 갖는 단백질을 제공한다.
또한 본 발명은 상기 단백질을 각각 코딩하는 서열번호1내지 서열번호25 중의 하나의 모낭형성능력을 갖는 단백질을 코딩하는 유전자를 제공한다.
이하, 본 발명을 상세하게 설명한다.
모유두(dermal papilla)는 모낭의 가장 아래쪽에 존재하는 세포로서 모발의 형성과 모발주기의 조절에 가장 중요한 역할을 하는 세포이다.
모유두세포(dermal papilla cell)는 중배엽에서 유래하였고 현재까지는 섬유아세포(dermal fibroblast)와 가장 유사한 세포로 알려지고 있다.
배양된 모유두 세포는 특이하게도 계대배양(passage)을 하지 않은 세포들은 모낭형성 능력이 있는 반면에 배양을 오래 할 수록 (passage 3 -4 이후) 모낭을 형성할 수 있는 능력이 점차 떨어지는 특징이 있다. 즉 실험실에서 세포를 배양할 수록 세포가 원래 가지고 있던 능력을 잃어버린다고 할 수 있다.
따라서 배양 초기의 모낭형성 능력을 지니고 있을 때 특이적으로 발현되는 유전자를 알게되면 이를 이용하여 오래 배양된 세포에 어떤 조건을 첨가하였을 때 다시 모낭형성 능력을 가지는 세포가 될 수 있을지 어떨지를 알아낼 수 있는 좋은 marker가 될 수 있다.
따라서 본 발명은 계대배양을 한번도 하지 않은 상태의 dermal papilla 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 유전자를 제공한다.
즉, 본 발명에서는 모 발생 및 주기를 조절하는 모유두세포를 더 잘 이해하기 위해 유전자 수준에서의 유전자 발현 프로화일을 모유두 및 밀접하게 연관된 섬유아세포(dermal fibroblasts)간에 사이에 cDNA 마이크로어레이 기술로 스크리닝하였다. 게다가 장기간 배양에 따른 모유두세포의 변화를 밝히기 위해 유전자 발현 프로화일을 모유두세포의 각 계대에서 비교하였다.
이하, 비한정적인 실시예를 통하여 본 발명을 더욱 상세하게 설명한다.
실시예 1: 모유두의 분리
DP 세포의 분리 및 배양은 기존의 방법(Horne, 등 J Embryol Exp Morph, 97, 111-124 (1986))에 따라 진행하였다. 남성형탈모를 갖는 5 환자에서 모발이식 수술시 공여부로 얻는 후두부 모발 조직에서 시료를 얻었다. 상기 시료를 즉시 Dulbecco's modified Eagle's medium (DMEM; Gibco BRL, Gaithersburg, MD, USA)에 넣었다. 각 성장기(anagen) 모발을 해부현미경(steromicroscope) 하에서 모유두를 분리하였다.
실시예 2: 모유두, 표피초(dermal sheath (DS) 및 섬유아세포 배양
동일조직샘플로부터 분리된 모유두의 외식편(explant)으로부터 DP 세포를 성장시켰다. 배양을 위한 조직을 penicillin (100 U/ml), streptomycin (100 ㎍/ml), L-glutamine (0.584 mg/ml), 및 20% 불활성화된 fetal calf serum (Gibco BRL)이 포함된 2ml의 DMEM을 갖는 다섯 35 mm 디시(7-10 DP explants/dish)에 넣고 5% CO2, 37℃에서 배양하였다. 외식편들은 처음 5일간 관찰하지 않은 채로 두고, 이후부터는 3일마다 배지를 갈아주었다. 약 4주 후에 일차 배양에서 약 70% 충만(confluent) 될 때, DP 세포들을 0.25% 트립신 및 0.02% EDTA 용액으로 채취하고 단일-세포 현탁액으로 계대시켰다. 차후의 계대배양에는 1:4로 나누었다. 계대배양 후에는 세포를 10% 불활성화된 fetal calf serum를 갖는 DMEM으로 바꾸어 유지하였다. 각 계대에 대해 1/4의 DP 세포를 채취하고 cDNA 마이크로어레이를 위해 보관하였다. 모낭주위 결합초(dermal sheath; DS) 세포 및 모낭사이(interfollicular) 표피 섬유아세포들을 DP 세포와 유사하게 배양하였다.
실시예 3: 전체 RNA 추출
전체 RNA는 변형된 acid phenol 방법을 사용하여 모유두 및 섬유아세포로부터 추출하였다. 간단하게 설명하면, 성장배지를 제거하고 세포를 Trizol (Life Technologies)로 용해시켰다. 용해액을 1/10 볼륨의 1-bromo-3-cholopropane을 첨가하여 추출하였다. 수용층을 새 튜브에 모아서 isopropanol로 침전시켰다. 75% ethanol 세척 후, 펠렛을 공기-건조시키고, DEPC-처리된 물로 재부유 시키고, UV spectrometer (DU530, Beckman, USA)를 사용한 A260/A280 측정에 의해 정량하였다. 양을 측정하기 위해, 1 μg 의 전체 변성 1.0 % 포름알데히드 아가로스 젤 상에 로딩하고 전기영동 하였다.
실시예 4: mRNA 분리
mRNA는 Dynabead mRNA 정제 키트(Dynal)를 사용하여 전체 RNA로부터 분리하였다. DP 세포로부터 얻은 전체 RNA를 65에 2 분간 가열하고, Dynabeads Oligo (dT)를 새 튜브속으로 분산시키고 상층액을 30초간 자석 내에 튜브를 위치시킨 후 제거하였다. Dynabeads 펠렛을 동량의 전체 RNA로 바인딩 버퍼 속에서 재부유한 후 상온에서 3분간 튜브를 회전하여 가열한 전체 RNA와 잘 혼합하였다. 튜브를 30초간 자석위에 위치시키고 상층액을 제거하였다. 그 펠렛을 버퍼로 2회 세척하고 용리(elution) 버퍼로 재부유한 후 65 ℃에서 2 분간 가열하였다. 그 펠렛을 자석위에 위치한 후 상등액을 새 PCR 튜브로 회수하였다.
실시예 5: in vitro 전사방법을 사용한 RNA 증폭
세포의 조기 계대 특히 일차 외식(explanted)된 디쉬에서 충분한 RNA를 얻는 것은 어렵기 때문에 모든 mRNA 샘플들은 T7 RNA polymerase를 이용하는 RNA 증폭법으로 일회 증폭 후 사용하였다. RNA 증폭은, mRNA를 T7-Oligo (dT) 프라이머로 혼합하고 70 ℃에서 10분간 가열하였다. 첫 가닥 cDNA를 제조하기 위해, 혼합물을 빠르게 얼음에서 냉각하고, First strand buffer, DTT 및 dNTP를 첨가하였다. 그 혼합물을 42℃에서 2분간 예열하고, Superscript II reverse transcriptase를 첨가하고 42 ℃에서 50 분간 정치하였다. 그 첫 가닥 cDNA에 second strand buffer, dNTP, E. coli DNA ligase, E. coli DNA polymerase, E. coli RNase H를 첨가하였다. 그 혼합물을 16 ℃에서 2 시간 정치한 후, T4 DNA polymerase를 첨가하고 16 ℃에서 5 분간 정치하였다. Second stranded cDNA를 페놀:크로로포름으로 추출하고 ammonium acetate 및 100 % ethanol로 -20 ℃에서 침전시켰다. 그 RNA를 4 ℃, 13,000 rpm에서 30 분간 원심분리하여 회수하였고, 그 RNA 펠렛을 75 % ethanol로 세척 후 공기중에서 건조한 펠렛을 DEPC-처리한 물로 녹였다. 이들 이중 가닥 cDNAs를 Ampliscribe T7 Transcription Kit를 사용한 in vitro 전사에 의해 증폭하였다. T7 특이적 프로모터로 주형 DNA를 리니어한 이중 가닥 cDNA를 T7 반응버퍼, ATP, CTP, GTP, UTP, 및 DTT와 혼합하였다. 그 혼합물을 37 ℃에서 5 분간 예열 후 Ampliscribe T7 RNA polymerase를 첨가하고 37 ℃에서 2.5시간 정치하였다. 그 후 RNA 산물을 TRI reagent solution (Gibco-BRL Grand Island, NY, USA) 및 1-Bromo-3-chloropropane과 혼합하고, 4 ℃에서 30분간 원심분리하였다. 그 상등액을 새 튜브로 옮기고 동량의 isopropanol을 첨가하였다. RNA를 침전시키기 위해, 그 혼합물을 -20 ℃에서 적어도 3시간 보존하고 4 ℃에서 30분간 원심분리하였다 그 펠렛을 75 % ethanol로 세척하고 DEPC-처리 물에 녹였다. 증폭된 RNA를 정제하기 위해 그 RNA를 Microcon-30로 여과하였다. 그 샘플을 컬럼에 로딩하고 13,000 rpm에서 7분간 회전하였다. 이 단계를 3회 반복 후 약 20 ㎕ 의 샘플을 회수하였다. 그 증폭된 RNA (aRNA)를 새 튜브로 회수하고 질과 양을 UV 분광기로 체크하였다.
실시예 6: aRNA으로부터 형광 DNA 프로브의 제조
형광표지된 프로브를 Khan J 등(Proc. Natl. Acad. Sci. USA, 96:13264-13269 (1999))의 방법에 따라 제조하였다. 섬유아세포를 녹색형광을 내는 Cy-3 dCTP로 표지하고 모유두의 각 계대를 적색형광인 Cy-5 dCTP(Amersham)로 표지하였다. 각 역전사반응에는 4 ㎍ aRNA 및 1 ㎍ random hexamer를 포함하였다. 역전사 후에 샘플을 각 1.0 ㎕ 의 1.5 M 수산화나트륨 및 30 mM EDTA로 65℃에서 10분간 처리한 후, 468 ㎕ 의 TE buffer (pH 7.4)를 사용하여 중화하였다. Microcon 30 (Millipore, USA)를 사용하여, 프로브를 정제하고 농축하였다. Cy-3 및 Cy-5 형광 표지된 프로브를 mg/ml poly A blocker (Amersham) 및 0.5 mg/ml yeast tRNA (Life Technologies)와 3 X SSC, 0.1 % SDS에서 최종 부피 25 ㎕로 혼합하였다.
실시예 7: 마이크로어레이 교잡화
실험실에서 직접 제작한 인간 4.7K cDNA 칩을 사용하였다. 그것은 모발(hair)-특이적 cDNA 마이크로어레이이고, 모유두 cDNA 라이브러리로부터 분리된 4,700 cDNA 클론을 가지고 있다. 본 발명에서는 실험의 각 세트 당 다섯 슬라이드 및 총 25 슬라이드가 사용되었다. Amino-silane 코팅된 슬라이드(CMT-GAPSTM, Corning)를 코플린 자(coplin jar) 3.5 > SSC, 0.1% SDS, 10 mg/ml BSA에서 50℃에서 20분간 프리-하이브리다이즈하고 물과 이소프로판올에 담구어 세척하고 원심분리를 사용하여 건조하였다. 그 제조된 프로브를 95-100℃에서 2분간 가열하여 변성하고 커버 슬라이드를 갖는 어레이 위에 놓았다. 교잡화는 50℃ 수조 내의 CMT-Hybridization 챔버(Corning)에서 20 시간동안 행하였다. 어레이를 일차세척 버퍼(0.1 > SSC/0.1 % SSC)로 상온에서 5분간 세척하고, 다시 이차세척 버퍼(0.1 > SSC)로 5분간 2회 세척한 후 원심분리를 사용하여 건조하였다.
실시예 8: 스캐닝 및 이미지 분석
고정화된 타겟에서 발생하는 형광 강도를 공초점 레이저 스캐너인 Scanarray 4000(GSI Lumonics, USA)를 사용하여 측정하였다. 두 형광 이미지들(Cy-3 및 Cy-5)을 각각 스캐닝하고 겹쳐진 색 이미지들을 섬유아세포 형광강도를 그린 채널로 모유두세포의 형광강도를 레드 채널로 산술적으로 할당하여 형성하였고, 데이터를 GenePix 소프트웨어(version 3.0, Axon Instruments, Inc)을 사용하여 분석하였다. 각 어레이 결과를 두가지 다른 형광색소를 가지고 표지와 검출에서 다른 효율을 위해 조정하기 위해 LOWESS 알고리즘에 의한 within-print-tip 군(Yang, Y. H., 등 Nucleic Acids Res. 30, e15. (2002))에 따라 표준화하였다. 노이즈 시그널을 제거하기 위해, 시그널 형광강도와 배경의 형광강도의 비가 1.4이하를 보이는 스팟들을 표준화과정에서 제거하였다.
실시예 9: 크러스터링 및 트리 뷰(tree view)를 위한 데이터 분석
모든 25 교잡화 반응에서에서 얻은 로그 비(log ratio)값들을 표 파일(tabular file)로 변화(merge)하였다. 관리되지 않은(unsupervised) 클러스터링 분석을 위해, 샘플의 70% 이상 존재하고 샘플에서 표준편차가 0.8이하인 어레이 성분만을 선택하였다. 계통 크러스터링(Hierachical clustering)을 유전자들 및 샘플 모두에 적용하였다. 분석은 M. Eisen에 의해 기재된 웹상 소프트웨어 Cluster 및 TreeView(Eisen MB, 등 Proc. Natl. Acad. Sci. USA, 95:14863-8 (1998))를 사용하여 수행하였다.
이상 실시예의 결과를 간단히 설명하면 다음과 같다.
DP특정 유전자를 스크리닝하기 위해, 본 발명자들은 DP cDNA 라이브러리로부터 4,700의 cDNA 클론을 포함한 실험실에서 제작한 cDNA microarray로 테스트했다.
내부 대조군으로 하우스키핑 유전자, 베타-actin, 및 글리셀알데히드 3-인산 탈수소산소(GAPDH)를 같은 어레이 상에 포함하였다.
microarray는 형광 색소로 표지된 cDNA 프로브에 의해 교잡했다.
프로브는 배양된 DP세포 제4의 계대까지 및 섬유아세포로부터 온 aRNA로 제조되었다.
형광 타겟을 엄격한 조건하에서 microarray상의 클론에 교잡하게 했다.
통합된 타겟의 레이저 익사이테이션은 특정의 스펙트럼을 가지는 발광을 내고, 그것을 공초점 레이저 스캐너를 사용해 측정된다. GenePix 소프트웨어를 이용하여 스캐너(Scanarray 4000)로부터 얻은 모노크롬 이미지를 임포트하고 슈도(pseudo)-색을 입혔다.
하이브리다이제이션 결과의 칼라 이미지는 Cy-3 형광성의 이미지를 그린 및 Cy-5 형광성 이미지를 레드로 표시하고, 두 개의 칼라 이미지를 합병하여 제조하였다.
그러한 하이브리다이제이션의 예는 도 1에 나타났다. 도 1은 DP에서 유래한 cDNA 프로브는 Cy-5 dUTP(적색), 섬유아세포로부터 온 cDNA 프로브는 Cy-3 dUTP(녹색)으로 표지시켰다.
그림에서 적색 및 녹색 형광 스팟은 DP 및 섬유아세포에서 각각 상대적으로 높은 발현을 나타내는 유전자를 의미하고 노란색 스팟은 두 종류의 세포에서 발현에 차이가 없는 유전자를 의미한다.
각 어레이 결과는 LOWESS 알고리즘에 의해 within-print-tip 그룹에 따라 표준화(normalization)하였고, 그 스팟 시그널 대 백그라운드 강도 비가 1.4 이하인 것을 노이즈 시그널로 간주하여 그것들을 여과했다.
표준화 및 여과 과정 후에 각 데이터세트는 플롯 그래프를 만들어 표준화단계를 체크하였다. 그리고 데이터는 Cluster 프로그램에 가져온 비율만을 갖는다.
25 쌍의 DP 및 섬유아세포 샘플 중에서 적어도 2쌍이 두 배 이상의 차이를 보이는 유전자들을 더 크러스터링 분석을 위해서 선택하였다.
이렇게 선택된 클론은 883 유전자들이고 크러스터링 결과 플롯은 도 2에 나타났다.
관리되지 않는 크러스터링 결과는 DP 및 섬유아세포의 유전자 형질 발현 차이를 차별화하기 용이하게 만들었다.
또한 그것은 계대 전(DP0)의 일차 외식체 DP세포의 유전자 형질 발현 프로화일이 계대 후의 것과 매우 차이가 있고, 계대 1(DP1)의 유전자 발현 프로화일은 계대 4(DP4)와 큰 차이가 없다는 것을 또한 보여준다.
크러스터링 분석에 의해, 차별적으로 발현된 유전자를 DP 세포 내에서 일반적으로 과잉 발현된 유전자들(도 3 및 표 1), DP0에서는 아니고, DP1에서 DP4에서만 업-레굴레이트된 유전자들 (도 4), DP0에서만 과잉 발현된 유전자들(표 2)로 나누었다.
섬유아세포와 비교하여 일반적으로 DP에서 과잉 발현된 유전자들(33 유전자)은 레티노익산 수용체, dickkopf 3, 이미디어트 얼리 리스폰스 3, 프로테오글리칸 1, 트랜스포밍 성장 인자 2(TGF-2), 인타루킨 11의 수용체, 시스테인 리치 단백질 2, 카드헤린(cadherin) 2, 메탈로프로테이즈 19, 트로포마이오신, transgelin 2, 라이실 옥시데이즈-like 2, 카트리지 링킹 단백질 1, 인히빈 베타 A 및 옥시토신 수용체를 포함한다.
DP0 및 섬유아세포와 비교하여 DP1에서 DP4에 이르는 계대된 DP세포에서 업-레귤레이트된 유전자들(47 유전자들)에는 콜라겐 IV형, netrin 4, 미오신경쇄 키나제,α평활근 엑틴, 칼포닌 1, 액티닌(actinin)α1, 골아세포 특정인자 2(OSF2), 감수 분열 체크포인트 조절 인자, 결합 조직 성장 인자(CTGF), 앤지오텐진 수용체 1 및 asporin을 포함한다.
다른 세포와 비교해 DP0에서 과잉발현된 27개의 유전자들은 콜라겐형 VII, DNA 바인딩 3 저해제, 종양 엔도쎄이얼 마커 6, 포크헤드 박스 M1, 프로테오리피드 단백질 2, pleiotrophin, 알도-케토·리덕테이즈 B1, syndecan 3, 메탈로프로테이즈 3 조직 인히비터(TIMP-3), sprouty 호모로지 4, 트란스케토레이즈, FXYD 도메인 5, CD9 및 SH3-도메인을 포함한다.
실시예 10: 노던 블럿
마이크로어레이 결과를 노던 교잡화로 확인하였다. RNA를 DP, DS, 및 섬유아세포로부터 얻어 각 10 ㎍의 전체 RNA를 1.0% 아가로스/포름알데히드 젤상에서 분리하고 나이론 막(Hybond N+; Amersham Biosciences, Burminghamshire, UK)으로 트랜스퍼하였다. 막들을 랜덩 프라임된 [32P]dCTP-표지된 cDNA 프로브로 ExpressHyb 교잡화 용액(Clontech, Palo Alto, CA)내에서 65℃에서 1시간 교잡하였다. 세척 후 막들을 하이 스트린전시에서 세척하고 X-레이 필름에 노출하였다.
microarray 결과를 확인하기 위해서, 노던 하이브리다이제이션을 수행하였다(도 6 및 7). 20개의 차별적으로 발현되는 유전자들을 DP, DS 및 섬유아세포에서 비교하였다. 노던 블럿 결과들은 microarray 데이터와 우수한 상관관계가 있었다. 두 다른 세포인 DP 및 섬유아세포 사이 안에서 DS세포의 유전자 형질 발현 프로화일을 보인다는 것은 흥미롭다.
진뱅크 ID | 유전자 명 | DP0 | DP 1~4 Average | DP1 | DP2 | DP3 | DP4 |
NM_016152.2 | retinoic acid receptor, beta | 4.24 | 2.8 | 3.2 | 3.7 | 4.1 | 3 |
NM_013253.1 | dickkopf homolog 3 | 3.68 | 3.28 | 3.5 | 4.2 | 4.5 | 4.2 |
NM_000903.1 | NAD(P)H dehydrogenase,quinone 1 | 3.47 | 1.82 | 2.2 | 2.1 | 2.4 | 2.4 |
NM_052815.1 | immediate early response 3 | 3.2 | 2.77 | 3.1 | 3.6 | 3.6 | 3.6 |
NM_002727.1 | proteoglycan 1 | 2.85 | 2.21 | 2.5 | 2.2 | 3.5 | 2.8 |
NM_003238.1 | TGFB2 | 2.81 | 3.66 | 4.4 | 4.6 | 5.1 | 4.2 |
NM_006622.1 | serum-inducible kinase | 2.78 | 2.64 | 3.3 | 2.7 | 3.8 | 3.4 |
NM_004512.2 | interleukin 11 receptor, alpha | 2.69 | 5.03 | 5.2 | 8.1 | 5.8 | 6.2 |
NM_001312.1 | cysteine-rich protein 2 | 2.56 | 1.9 | 2.2 | 2.1 | 3 | 2.2 |
NM_007173.2 | protease, serine, 23 | 2.55 | 2.91 | 3.1 | 4 | 3.3 | 4.2 |
NM_000995.2 | ribosomal protein L34 | 2.33 | 2.62 | 3.2 | 3.4 | 4 | 2.4 |
NM_001792.2 | cadherin 2, type 1 | 2.33 | 3.74 | 6.4 | 4.9 | 3.8 | 3.6 |
NM_033274.1 | disintegrin and metalloproteinase,19 | 2.3 | 2.77 | 3.5 | 3.9 | 3.6 | 2.8 |
NM_006516.1 | solute carrier family 2, member 1 | 2.3 | 2.34 | 2.5 | 3.5 | 2.5 | 3.2 |
NM_024427.1 | Mus musculus tropomyosin 1α | 2.3 | 2.98 | 3.2 | 3.9 | 3.3 | 4.4 |
NM_004137.1 | calcium-activated channel | 2.28 | 4.76 | 4.6 | 7.1 | 6.5 | 5.6 |
NM_080630.1 | collagen, type XI, alpha 1 | 2.15 | 6.17 | 6.2 | 8.6 | 8 | 8.2 |
NM_000366.2 | tropomyosin 1 - alpha | 2.05 | 2.94 | 2.7 | 3.9 | 3.8 | 4.3 |
NM_020992.2 | PDZ and LIM domain 1 (elfin) | 2.01 | 2.61 | 2.9 | 3.2 | 3.6 | 3.3 |
NM_134034.1 | Mus musculus AW011752 | 1.96 | 2.07 | 2.8 | 2.7 | 2.3 | 2.5 |
NM_005245.1 | FAT tumor suppressor homolog 1 | 1.91 | 1.86 | 2.3 | 2.5 | 2.5 | 2 |
NM_003564.1 | transgelin 2 | 1.89 | 1.43 | 1.4 | 1.6 | 2.3 | 1.8 |
NM_002318.1 | lysyl oxidase-like 2 | 1.85 | 3.53 | 3.5 | 5.1 | 4.3 | 4.9 |
NM_001884.1 | cartilage linking protein 1 | 1.83 | 3.18 | 4.5 | 3.7 | 4 | 3.7 |
NM_002192.1 | inhibin, beta A | 1.74 | 2.02 | 2.3 | 2.6 | 2.7 | 2.5 |
NM_000916.2 | oxytocin receptor | 1.7 | 2.09 | 2.4 | 2.9 | 2.8 | 2.4 |
NM_022542.1 | Rattus norvegicus rhoB gene | 1.7 | 2.33 | 2.5 | 2.8 | 3.4 | 2.9 |
AK021874 | cDNA FLJ11812 fis | 3.13 | 3.67 | 5.1 | 4.1 | 5.8 | 3.3 |
AY027862 | mammalian ependymin-RP1 | 2.43 | 3.22 | 3.6 | 4.4 | 3.9 | 4.2 |
AA806104 | oc25c05.s1 cDNA, 3' end | 2.43 | 2.26 | 2.4 | 2.6 | 3.3 | 3.1 |
AK056751 | cDNA FLJ32189 fis | 2.06 | 2.19 | 2.5 | 2.5 | 3.3 | 2.6 |
AV652424 | AV652424 cDNA, 3' end | 1.99 | 2.09 | 2.4 | 2.6 | 2.8 | 2.8 |
AK026116 | cDNA: FLJ22463 fis | 1.83 | 1.72 | 2 | 1.9 | 2.5 | 2.2 |
A1231 | 2.96 | 3.2 | 3.8 | 4.2 | 4 | 4 |
진뱅크 ID | 유전자 명 | DP0 | DP1~4 Average | DP1 | DP2 | DP3 | DP4 |
NM_000094.2 | collagen, type VII, alpha 1(서열목록1) | 2.66 | 1.4 | 1.9 | 2.1 | 1.49 | 1.55 |
NM_002167.1 | inhibitor of DNA binding 3(서열목록2) | 2.63 | 1.54 | 1.3 | 2.2 | 2.33 | 1.89 |
NM_022748.6 | tumor endothelial marker 6 (서열목록3) | 2.54 | 1.45 | 1.9 | 1.8 | 1.71 | 1.82 |
NM_003981.1 | protein regulator of cytokinesis 1(서열목록4) | 2.48 | 0.9 | 0.8 | 0.8 | 1.41 | 1.47 |
NM_006818.2 | ALL1-fused gene from ch 1q (서열목록5) | 2.45 | 1.74 | 2.1 | 2.2 | 2.4 | 1.97 |
NM_021953.1 | forkhead box M1 (서열목록6) | 2.34 | 0.79 | 1 | 0.7 | 1.16 | 1 |
NM_018131.2 | hypothetical protein FLJ10540 (서열목록7) | 2.27 | 0.87 | 1 | 0.7 | 1.39 | 1.2 |
NM_003878.1 | gamma-glutamyl hydrolase(서열목록8) | 2.25 | 1.11 | 1.4 | 1.2 | 1.44 | 1.57 |
NM_024056.1 | hypothetical protein MGC5576 (서열목록9) | 2.14 | 1.63 | 1.8 | 2.1 | 2.04 | 2.16 |
NM_002668.1 | proteolipid protein 2 (서열목록10) | 2.13 | 1.37 | 1.5 | 1.5 | 2.03 | 1.79 |
NM_031476.1 | hypothetical protein DKFZp434B044(서열목록11) | 2.12 | 1.38 | 2.1 | 2.3 | 1.41 | 1.07 |
NM_001634.3 | S-adenosylmethionine decarboxylase 1 (서열목록12) | 2.1 | 0.8 | 1 | 0.9 | 1.1 | 0.96 |
NM_002825.2 | pleiotrophin (서열목록13) | 2.1 | 1.02 | 1.4 | 1.2 | 1.48 | 1.05 |
NM_001628.1 | aldo-keto reductase 1, B1(서열목록14) | 2.07 | 0.69 | 1 | 0.9 | 0.81 | 0.81 |
NM_014654.1 | syndecan 3 (서열목록15) | 2.01 | 1.13 | 1.4 | 1.7 | 1.2 | 1.38 |
NM_000362.3 | tissue inhibitor of metalloproteinase 3(서열목록16) | 2.01 | 0.99 | 1.3 | 1.2 | 1.25 | 1.23 |
NM_030964.1 | sprouty homolog 4 (서열목록17) | 1.99 | 0.43 | 0.5 | 0.6 | 0.44 | 0.59 |
NM_001064.1 | transketolase(서열목록18) | 1.99 | 0.99 | 1.3 | 1.2 | 1.03 | 1.38 |
NM_014164.3 | FXYD domain, 5 (서열목록19) | 1.98 | 1.27 | 1.5 | 1.6 | 1.64 | 1.61 |
NM_001769.2 | CD9 antigen (p24)(서열목록20) | 1.86 | 1.1 | 1.6 | 1.4 | 1.24 | 1.3 |
NM_002818.1 | proteasome ,activator subunit 2(서열목록21) | 1.84 | 1.22 | 1.5 | 1.5 | 1.43 | 1.63 |
NM_024745.1 | hypothetical protein FLJ22009(서열목록22) | 1.81 | 0.9 | 1.2 | 0.9 | 1.35 | 0.97 |
NM_014521.1 | SH3-domain binding protein 4 (서열목록23) | 1.81 | 1.32 | 1.6 | 1.5 | 1.93 | 1.51 |
AL080156 | cDNA DKFZp434J214 (서열목록24) | 2.41 | 1.03 | 1.2 | 1.1 | 1.4 | 1.53 |
AK026116 | cDNA: FLJ22463 fis(서열목록25) | 1.83 | 1.72 | 2 | 1.9 | 2.54 | 2.16 |
HC2613 | 1.88 | 0.68 | 0.9 | 0.8 | 0.91 | 0.79 | |
K982-5 | 1.86 | 1.33 | 1.7 | 1.9 | 1.4 | 1.65 |
상기 표2에서 알 수 있는 DP0에서 특이적으로 발현되는 유전자들은 모낭형성능력을 가지므로, 배양 초기의 모낭형성 능력을 지니고 있을 때 특이적으로 발현되는 유전자를 알게되면 이를 이용하여 오래 배양된 세포에 어떤 조건을 첨가하였을 때 다시 모낭형성 능력을 가지는 세포 여부를 알아낼 수 있는 좋은 표식이 될 수 있다.
도 1은 마이크로어레이 검출의 결과를 보여주는 사진. 전체 마이크로어레이는 인간의 DP세포 cDNA 라이브러리에 유래한 4,700 유전자를 포함하고, 섬유아세포로부터의 RNA 샘플은 Cy3-dUTP(녹색 형광)으로 표지하였고, DP는 Cy5-dUTP(붉은 형광)으로 표지하였다.
도 2는 25쌍의 모유두 및 섬유아세포의 마이크로어레이 결과의 선택된 886 유전자의 크러스터된 데이터 세트의 트리 뷰 이미지를 보여주는 사진이다. 최초 4자리 숫자는 샘플 식별 번호이다. DP0는 계대 전에 일차 배양된 DP세포를 의미하고, DP1에서 DP4는 각 계대배양으로부터 얻은 DP세포를 의미한다. 수직축은 세포주에 횡축은 유전자에 해당된다.
도 3은 인간 모유두 세포에서 일반적으로 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.
도 4는 계대 후 인간 모유두 세포에서 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.
도 5는 섬유아세포에서 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.
도 6은 모유두 특이적 유전자들의 노던 하이브리다이제이션을 보여주는 사진이다.
도 7은 섬유아세포 특이적 유전자들의 노던 하이브리다이제이션을 보여주는 사진이다.
<110> Kyungpook National University Industrial Collaboration Foundation
<120> Genes with activity forming hair follicle
<160> 49
<170> KopatentIn 1.71
<210> 1
<211> 9272
<212> DNA
<213> Homo sapiens
<400> 1
gggctggagg ggcgctgggc tcggacctgc caaggccacc gcagggggga gcaagggaca 60
gaggcggggg tcctagctga cggcttttac tgcctaggat gacgctgcgg cttctggtgg 120
ccgcgctctg cgccgggatc ctggcagagg cgccccgagt gcgagcccag cacagggaga 180
gagtgacctg cacgcgcctt tacgccgctg acattgtgtt cttactggat ggctcctcat 240
ccattggccg cagcaatttc cgcgaggtcc gcagctttct cgaagggctg gtgctgcctt 300
tctctggagc agccagtgca cagggtgtgc gctttgccac agtgcagtac agcgatgacc 360
cacggacaga gttcggcctg gatgcacttg gctctggggg tgatgtgatc cgcgccatcc 420
gtgagcttag ctacaagggg ggcaacactc gcacaggggc tgcaattctc catgtggctg 480
accatgtctt cctgccccag ctggcccgac ctggtgtccc caaggtctgc atcctgatca 540
cagacgggaa gtcccaggac ctggtggaca cagctgccca aaggctgaag gggcaggggg 600
tcaagctatt tgctgtgggg atcaagaatg ctgaccctga ggagctgaag cgagttgcct 660
cacagccaac ctccgacttc ttcttcttcg tcaatgactt cagcatcttg aggacactac 720
tgcccctcgt ttcccggaga gtgtgcacga ctgctggtgg cgtgcctgtg acccgacctc 780
cggatgactc gacctctgct ccacgagacc tggtgctgtc tgagccaagc agccaatcct 840
tgagagtaca gtggacagcg gccagtggcc ctgtgactgg ctacaaggtc cagtacactc 900
ctctgacggg gctgggacag ccactgccga gtgagcggca ggaggtgaac gtcccagctg 960
gtgagaccag tgtgcggctg cggggtctcc ggccactgac cgagtaccaa gtgactgtga 1020
ttgccctcta cgccaacagc atcggggagg ctgtgagcgg gacagctcgg accactgccc 1080
tagaagggcc ggaactgacc atccagaata ccacagccca cagcctcctg gtggcctggc 1140
ggagtgtgcc aggtgccact ggctaccgtg tgacatggcg ggtcctcagt ggtgggccca 1200
cacagcagca ggagctgggc cctgggcagg gttcagtgtt gctgcgtgac ttggagcctg 1260
gcacggacta tgaggtgacc gtgagcaccc tatttggccg cagtgtgggg cccgccactt 1320
ccctgatggc tcgcactgac gcttctgttg agcagaccct gcgcccggtc atcctgggcc 1380
ccacatccat cctcctttcc tggaacttgg tgcctgaggc ccgtggctac cggttggaat 1440
ggcggcgtga gactggcttg gagccaccgc agaaggtggt actgccctct gatgtgaccc 1500
gctaccagtt ggatgggctg cagccgggca ctgagtaccg cctcacactc tacactctgc 1560
tggagggcca cgaggtggcc acccctgcaa ccgtggttcc cactggacca gagctgcctg 1620
tgagccctgt aacagacctg caagccaccg agctgcccgg gcagcgggtg cgagtgtcct 1680
ggagcccagt ccctggtgcc acccagtacc gcatcattgt gcgcagcacc cagggggttg 1740
agcggaccct ggtgcttcct gggagtcaga cagcattcga cttggatgac gttcaggctg 1800
ggcttagcta cactgtgcgg gtgtctgctc gagtgggtcc ccgtgagggc agtgccagtg 1860
tcctcactgt ccgccgggag ccggaaactc cacttgctgt tccagggctg cgggttgtgg 1920
tgtcagatgc aacgcgagtg agggtggcct ggggacccgt ccctggagcc agtggatttc 1980
ggattagctg gagcacaggc agtggtccgg agtccagcca gacactgccc ccagactcta 2040
ctgccacaga catcacaggg ctgcagcctg gaaccaccta ccaggtggct gtgtcggtac 2100
tgcgaggcag agaggagggc cctgctgcag tcatcgtggc tcgaacggac ccactgggcc 2160
cagtgaggac ggtccatgtg actcaggcca gcagctcatc tgtcaccatt acctggacca 2220
gggttcctgg cgccacagga tacagggttt cctggcactc agcccacggc ccagagaaat 2280
cccagttggt ttctggggag gccacggtgg ctgagctgga tggactggag ccagatactg 2340
agtatacggt gcatgtgagg gcccatgtgg ctggcgtgga tgggccccct gcctctgtgg 2400
ttgtgaggac tgcccctgag cctgtgggtc gtgtgtcgag gctgcagatc ctcaatgctt 2460
ccagcgacgt tctacggatc acctgggtag gggtcactgg agccacagct tacagactgg 2520
cctggggccg gagtgaaggc ggccccatga ggcaccagat actcccagga aacacagact 2580
ctgcagagat ccggggtctc gaaggtggag tcagctactc agtgcgagtg actgcacttg 2640
tcggggaccg cgagggcaca cctgtctcca ttgttgtcac tacgccgcct gaggctccgc 2700
cagccctggg gacgcttcac gtggtgcagc gcggggagca ctcgctgagg ctgcgctggg 2760
agccggtgcc cagagcgcag ggcttccttc tgcactggca acctgagggt ggccaggaac 2820
agtcccgggt cctggggccc gagctcagca gctatcacct ggacgggctg gagccagcga 2880
cacagtaccg cgtgaggctg agtgtcctag ggccggctgg agaagggccc tctgcagagg 2940
tgactgcgcg cactgagtca cctcgtgttc caagcattga actacgtgtg gtggacacct 3000
cgatcgactc ggtgactttg gcctggactc cagtgtccag ggcatccagc tacatcctat 3060
cctggcggcc actcagaggc cctggccagg aagtgcctgg gtccccgcag acacttccag 3120
ggatctcaag ctcccagcgg gtgacagggc tagagcctgg cgtctcttac atcttctccc 3180
tgacgcctgt cctggatggt gtgcggggtc ctgaggcatc tgtcacacag acgccagtgt 3240
gcccccgtgg cctggcggat gtggtgttcc taccacatgc cactcaagac aatgctcacc 3300
gtgcggaggc tacgaggagg gtcctggagc gtctggtgtt ggcacttggg cctcttgggc 3360
cacaggcagt tcaggttggc ctgctgtctt acagtcatcg gccctcccca ctgttcccac 3420
tgaatggctc ccatgacctt ggcattatct tgcaaaggat ccgtgacatg ccctacatgg 3480
acccaagtgg gaacaacctg ggcacagccg tggtcacagc tcacagatac atgttggcac 3540
cagatgctcc tgggcgccgc cagcacgtac caggggtgat ggttctgcta gtggatgaac 3600
ccttgagagg tgacatattc agccccatcc gtgaggccca ggcttctggg cttaatgtgg 3660
tgatgttggg aatggctgga gcggacccag agcagctgcg tcgcttggcg ccgggtatgg 3720
actctgtcca gaccttcttc gccgtggatg atgggccaag cctggaccag gcagtcagtg 3780
gtctggccac agccctgtgt caggcatcct tcactactca gccccggcca gagccctgcc 3840
cagtgtattg tccaaagggc cagaaggggg aacctggaga gatgggcctg agaggacaag 3900
ttgggcctcc tggcgaccct ggcctcccgg gcaggaccgg tgctcccggc ccccaggggc 3960
cccctggaag tgccactgcc aagggcgaga ggggcttccc tggagcagat gggcgtccag 4020
gcagccctgg ccgcgccggg aatcctggga cccctggagc ccctggccta aagggctctc 4080
cagggttgcc tggccctcgt ggggacccgg gagagcgagg acctcgaggc ccaaaggggg 4140
agccgggggc tcccggacaa gtcatcggag gtgaaggacc tgggcttcct gggcggaaag 4200
gggaccctgg accatcgggc ccccctggac ctcgtggacc actgggggac ccaggacccc 4260
gtggcccccc agggcttcct ggaacagcca tgaagggtga caaaggcgat cgtggggagc 4320
ggggtccccc tggaccaggt gaaggtggca ttgctcctgg ggagcctggg ctgccgggtc 4380
ttcccggaag ccctggaccc caaggccccg ttggcccccc tggaaagaaa ggagaaaaag 4440
gtgactctga ggatggagct ccaggcctcc caggacaacc tgggtctccg ggtgagcagg 4500
gcccacgggg acctcctgga gctattggcc ccaaaggtga ccggggcttt ccagggcccc 4560
tgggtgaggc tggagagaag ggcgaacgtg gacccccagg cccagcggga tcccgggggc 4620
tgccaggggt tgctggacgt cctggagcca agggtcctga agggccacca ggacccactg 4680
gccgccaagg agagaagggg gagcctggtc gccctgggga ccctgcagtg gtgggacctg 4740
ctgttgctgg acccaaagga gaaaagggag atgtggggcc cgctgggccc agaggagcta 4800
ccggagtcca aggggaacgg ggcccacccg gcttggttct tcctggagac cctggcccca 4860
agggagaccc tggagaccgg ggtcccattg gccttactgg cagagcagga cccccaggtg 4920
actcagggcc tcctggagag aagggagacc ctgggcggcc tggcccccca ggacctgttg 4980
gcccccgagg acgagatggt gaagttggag agaaaggtga cgagggtcct ccgggtgacc 5040
cgggtttgcc tggaaaagca ggcgagcgtg gccttcgggg ggcacctgga gttcgggggc 5100
ctgtgggtga aaagggagac cagggagatc ctggagagga tggacgaaat ggcagccctg 5160
gatcatctgg acccaagggt gaccgtgggg agccgggtcc cccaggaccc ccgggacggc 5220
tggtagacac aggacctgga gccagagaga agggagagcc tggggaccgc ggacaagagg 5280
gtcctcgagg gcccaagggt gatcctggcc tccctggagc ccctggggaa aggggcattg 5340
aagggtttcg gggaccccca ggcccacagg gggacccagg tgtccgaggc ccagcaggag 5400
aaaagggtga ccggggtccc cctgggctgg atggccggag cggactggat gggaaaccag 5460
gagccgctgg gccctctggg ccgaatggtg ctgcaggcaa agctggggac ccagggagag 5520
acgggcttcc aggcctccgt ggagaacaag gcctccctgg cccctctggt ccccctggat 5580
taccgggaaa gccaggcgag gatgggaaac ctggcctgaa tggaaaaaac ggagaacctg 5640
gggaccctgg agaagacggg aggaagggag agaaaggaga ttcaggcgcc tctgggagag 5700
aaggtcgtga tggccccaag ggtgagcgtg gagctcctgg tatccttgga ccccaggggc 5760
ctccaggcct cccagggcca gtgggccctc ctggccaggg ttttcctggt gtcccaggag 5820
gcacgggccc caagggtgac cgtggggaga ctggatccaa aggggagcag ggcctccctg 5880
gagagcgtgg cctgcgagga gagcctggaa gtgtgccgaa tgtggatcgg ttgctggaaa 5940
ctgctggcat caaggcatct gccctgcggg agatcgtgga gacctgggat gagagctctg 6000
gtagcttcct gcctgtgccc gaacggcgtc gaggccccaa gggggactca ggcgaacagg 6060
gccccccagg caaggagggc cccatcggct ttcctggaga acgcgggctg aagggcgacc 6120
gtggagaccc tggccctcag gggccacctg gtctggccct tggggagagg ggcccccccg 6180
ggccttccgg ccttgccggg gagcctggaa agcctggtat tcccgggctc ccaggcaggg 6240
ctgggggtgt gggagaggca ggaaggccag gagagagggg agaacgggga gagaaaggag 6300
aacgtggaga acagggcaga gatggccctc ctggactccc tggaacccct gggccccccg 6360
gaccccctgg ccccaaggtg tctgtggatg agccaggtcc tggactctct ggagaacagg 6420
gaccccctgg actcaagggt gctaaggggg agccgggcag caatggtgac caaggtccca 6480
aaggagacag gggtgtgcca ggcatcaaag gagaccgggg agagcctgga ccgaggggtc 6540
aggacggcaa cccgggtcta ccaggagagc gtggtatggc tgggcctgaa gggaagccgg 6600
gtctgcaggg tccaagaggc ccccctggcc cagtgggtgg tcatggagac cctggaccac 6660
ctggtgcccc gggtcttgct ggccctgcag gaccccaagg accttctggc ctgaaggggg 6720
agcctggaga gacaggacct ccaggacggg gcctgactgg acctactgga gctgtgggac 6780
ttcctggacc ccccggccct tcaggccttg tgggtccaca ggggtctcca ggtttgcctg 6840
gacaagtggg ggagacaggg aagccgggag ccccaggtcg agatggtgcc agtggaaaag 6900
atggagacag agggagccct ggtgtgccag ggtcaccagg tctgcctggc cctgtcggac 6960
ctaaaggaga acctggcccc acgggggccc ctggacaggc tgtggtcggg ctccctggag 7020
caaagggaga gaagggagcc cctggaggcc ttgctggaga cctggtgggt gagccgggag 7080
ccaaaggtga ccgaggactg ccagggccgc gaggcgagaa gggtgaagct ggccgtgcag 7140
gggagcccgg agaccctggg gaagatggtc agaaaggggc tccaggaccc aaaggtttca 7200
agggtgaccc aggagtcggg gtcccgggct cccctgggcc tcctggccct ccaggtgtga 7260
agggagatct gggcctccct ggcctgcccg gtgctcctgg tgttgttggg ttcccgggtc 7320
agacaggccc tcgaggagag atgggtcagc caggccctag tggagagcgg ggtctggcag 7380
gccccccagg gagagaagga atcccaggac ccctggggcc acctggacca ccggggtcag 7440
tgggaccacc tggggcctct ggactcaaag gagacaaggg agaccctgga gtagggctgc 7500
ctgggccccg aggcgagcgt ggggagccag gcatccgggg tgaagatggc cgccccggcc 7560
aggagggacc ccgaggactc acggggcccc ctggcagcag gggagagcgt ggggagaagg 7620
gtgatgttgg gagtgcagga ctaaagggtg acaagggaga ctcagctgtg atcctggggc 7680
ctccaggccc acggggtgcc aagggggaca tgggtgaacg agggcctcgg ggcttggatg 7740
gtgacaaagg acctcgggga gacaatgggg accctggtga caagggcagc aagggagagc 7800
ctggtgacaa gggctcagcc gggttgccag gactgcgtgg actcctggga ccccagggtc 7860
aacctggtgc agcagggatc cctggtgacc cgggatcccc aggaaaggat ggagtgcctg 7920
gtatccgagg agaaaaagga gatgttggct tcatgggtcc ccggggcctc aagggtgaac 7980
ggggagtgaa gggagcctgt ggccttgatg gagagaaggg agacaaggga gaagctggtc 8040
ccccaggccg ccccgggctg gcaggacaca aaggagagat gggggagcct ggtgtgccgg 8100
gccagtcggg ggcccctggc aaggagggcc tgatcggtcc caagggtgac cgaggctttg 8160
acgggcagcc aggccccaag ggtgaccagg gcgagaaagg ggagcgggga accccaggaa 8220
ttgggggctt cccaggcccc agtggaaatg atggctctgc tggtccccca gggccacctg 8280
gcagtgttgg tcccagaggc cccgaaggac ttcagggcca gaagggtgag cgaggtcccc 8340
ccggagagag agtggtgggg gctcctgggg tccctggagc tcctggcgag agaggggagc 8400
aggggcggcc agggcctgcc ggtcctcgag gcgagaaggg agaagctgca ctgacggagg 8460
atgacatccg gggctttgtg cgccaagaga tgagtcagca ctgtgcctgc cagggccagt 8520
tcatcgcatc tggatcacga cccctcccta gttatgctgc agacactgcc ggctcccagc 8580
tccatgctgt gcctgtgctc cgcgtctctc atgcagagga ggaagagcgg gtaccccctg 8640
aggatgatga gtactctgaa tactccgagt attctgtgga ggagtaccag gaccctgaag 8700
ctccttggga tagtgatgac ccctgttccc tgccactgga tgagggctcc tgcactgcct 8760
acaccctgcg ctggtaccat cgggctgtga caggcagcac agaggcctgt cacccttttg 8820
tctatggtgg ctgtggaggg aatgccaacc gttttgggac ccgtgaggcc tgcgagcgcc 8880
gctgcccacc ccgggtggtc cagagccagg ggacaggtac tgcccaggac tgaggcccag 8940
ataatgagct gagattcagc atcccctgga ggagtcgggg tctcagcaga accccactgt 9000
ccctcccctt ggtgctagag gcttgtgtgc acgtgagcgt gcgagtgcac gtccgttatt 9060
tcagtgactt ggtcccgtgg gtctagcctt cccccctgtg gacaaacccc cattgtggct 9120
cctgccaccc tggcagatga ctcactgtgg gggggtggct gtgggcagtg agcggatgtg 9180
actggcgtct gacccgcccc ttgacccaag cctgtgatga catggtgctg attctggggg 9240
gcattaaagc tgctgtttta aaaggcaaaa aa 9272
<210> 2
<211> 1203
<212> DNA
<213> Homo sapiens
<400> 2
gatctggggt gctgccagga aaaagcaaat tctggaagtt aatggttttg agtgattttt 60
aaatccttgc tggcggagag gcccgcctct ccccggtatc agcgcttcct cattctttga 120
atccgcggct ccgcggtctt cggcgtcaga ccagccggag gaagcctgtt tgcaatttaa 180
gcgggctgtg aacgcccagg gccggcgggg gcggggccga ggcgggccat tttgaataaa 240
gaggcgtgcc ttccaggcag gctctataag tgaccgccgc ggcgagcgtg cgcgcgttgc 300
aggtcactgt agcggacttc ttttggtttt ctttctcttt ggggcacctc tggactcact 360
ccccagcatg aaggcgctga gcccggtgcg cggctgctac gaggcggtgt gctgcctgtc 420
ggaacgcagt ctggccatcg cccggggccg agggaagggc ccggcagctg aggagccgct 480
gagcttgctg gacgacatga accactgcta ctcccgcctg cgggaactgg tacccggagt 540
cccgagaggc actcagctta gccaggtgga aatcctacag cgcgtcatcg actacattct 600
cgacctgcag gtagtcctgg ccgagccagc ccctggaccc cctgatggcc cccaccttcc 660
catccagaca gccgagctcg ctccggaact tgtcatctcc aacgacaaaa ggagcttttg 720
ccactgactc ggccgtgtcc tgacacctcc agaacgcagg tgctggcgcc cgttctgcct 780
gggaccccgg gaacctctcc tgccggaagc cggacggcag ggatgggccc caacttcgcc 840
ctgcccactt gacttcacca aatcccttcc tggagactaa acctggtgct caggagcgaa 900
ggactgtgaa cttgtagcct gaagagccag agctagctct ggccaccagc tgggcgacgt 960
caccctgctc ccaccccacc cccaagttct aaggtctttt cagagcgtgg aggtgtggaa 1020
ggagtggctg ctctccaaac tatgccaagg cggcggcaga gctggtcttc tggtctcctt 1080
ggagaaaggt tctgttgccc tgatttatga actctataat agagtatata ggttttgtac 1140
cttttttaca ggaaggtgac tttctgtaac aatgcgatgt atattaaact ttttataaaa 1200
gtt 1203
<210> 3
<211> 6702
<212> DNA
<213> Homo sapiens
<400> 3
ccccgactag cccgacagtc cccgactagc ccgacagccc cagcaggatc tgcatcgtca 60
tcgagccggc ccagcttctg aagggagatg tcatggtgaa atgctaccac aagaaatacc 120
gctcggccac ccgtgacgtc attttccgcc tgcagtttca cactggggct gtgcagggct 180
acgggctggt gtttgggaag gaggatctgg acaatgccag caaagatgac cgttttcctg 240
actatgggaa ggttgaatta gtcttctctg ccacgcctga gaagattcaa gggtccgaac 300
acttgtacaa cgaccacggt gtgattgtgg actacaacac aacagaccca ctgatacgct 360
gggactcgta cgagaacctc agtgcagatg gagaagtgct acacacgcag ggccctgtcg 420
atggcagcct ttacgcgaag gtgaggaaga aaagctcctc ggatcctggc atcccaggtg 480
gcccccaggc aatcccggcc accaacagcc cagaccacag tgaccacacc ttgtctgtca 540
gcagtgactc cggccactct acagcctctg ccaggacgga taagacggaa gagcgcctgg 600
ccccaggaac caggaggggc ctgagtgccc aggagaaggc agagttggac cagctgctca 660
gtggctttgg cctggaagat cctggaagct ccctcaagga aatgactgat gctcgaagca 720
agtacagtgg gacccgccac gtggtgccag cccaggttca cgtgaatgga gacgctgctc 780
tgaaggatcg ggagacagac attctggatg acgagatgcc ccaccacgac ctgcacagtg 840
tggacagcct tgggaccctg tcctcctcgg aagggcctca gtcggcccac ctgggtccct 900
tcacctgcca caagagcagc cagaactcac tcctatctga cggttttggc agcaacgttg 960
gtgaagatcc gcagggcacc ctcgttccgg acctgggcct tggcatggac ggcccctatg 1020
agcgggagcg gacttttggg agtcgagagc ccaagcagcc ccagcccctg ctgagaaagc 1080
cctcagtgtc cgcccagatg caggcctatg ggcagagcag ctactccaca cagacctggg 1140
tgcgccagca gcagatggtt gtagctcacc agtatagctt cgccccagat ggggaggccc 1200
ggctggtgag ccgctgccct gcagacaatc ctggcctcgt ccaggcccag cccagagtgc 1260
cactcacccc cacccgaggg accagcagta gggtggctgt ccagaggggt gtaggcagtg 1320
ggccacatcc ccctgacaca cagcagccct ctcccagcaa agcgttcaaa cccaggtttc 1380
caggagacca ggttgtgaat ggagccggcc cagagctgag cacaggcccc tccccaggct 1440
cgcccaccct ggacatcgac cagtccatcg agcagctcaa caggctgatc ctggagctgg 1500
atcccacctt cgagcccatc cctacccaca tgaacgccct cggtagccag gccaatggct 1560
ctgtgtctcc agacagcgtg ggaggtgggc tccgggcaag cagcaggctg cctgacacag 1620
gagagggccc cagcagggcc accgggcggc aaggctcctc tgctgaacag cccctgggcg 1680
ggagactcag gaagctgagc ctggggcagt acgacaacga tgctgggggg cagctgccct 1740
tctccaaatg tgcatgggga aaggctggtg tggactatgc cccaaacctg ccgccattcc 1800
cctcaccagc ggacgtcaaa gagacgatga cccctggcta tccccaggac ctcgatatta 1860
tcgatggcag aattttaagt agcaaggagt ccatgtgttc aactccagca tttcctgtgt 1920
ctccagagac accgtatgtg aaaacagcgc tgcgccatcc tccgttcagc ccacctgagc 1980
ccccgctgag cagcccagcc agtcagcaca aaggaggacg tgaaccacga agctgccctg 2040
agacgctcac tcacgctgtg gggatgtcag agagccccat cggacccaaa tccacgatgc 2100
tccgggctga tgcgtcctcg acgccctcct ttcagcaggc ttttgcttct tcctgcacca 2160
tttccagcaa cggccctggg cagaggagag agagctcctc ttctgcagaa cgccagtggg 2220
tggagagcag ccccaagccc atggtttccc tgctggggag cggccggccc accggaagtc 2280
ccctcagcgc tgagttctcc ggtaccagga aggactcccc agtgctgtcc tgcttcccgc 2340
cgtcagagct ccaggctcct ttccacagcc atgagctgtc cctagcagag ccaccggact 2400
ccctggcgcc tcccagcagc caggccttcc tgggcttcgg caccgcccca gtgggaagtg 2460
gccttccgcc cgaggaggac ctgggggcct tgctggccaa ttctcatgga gcgtcaccga 2520
cccccagcat cccgctgaca gcgacagggg ctgccgacaa tggcttcctg tcccacaact 2580
ttctcacggt ggcgcctgga cacagcagcc accacagtcc aggcctgcag ggccagggtg 2640
tgaccctgcc cgggcagcca cccctccctg agaagaagcg ggcctcggag ggggatcgtt 2700
ctttgggctc agtctctccc tcctccagtg gcttctccag cccgcacagc gggagcacca 2760
tcagtatccc cttcccaaat gtccttcccg acttttccaa ggcttcagaa gcggcctcac 2820
ctctgccaga tagtccaggt gataaacttg tgatcgtgaa atttgttcaa gacacttcca 2880
agttctggta caaggcggat atttcaagag aacaagccat cgccatgttg aaggacaagg 2940
agccgggctc attcattgtt cgagacagcc attccttccg aggggcctat ggcctggcca 3000
tgaaggtggc cacgccccca ccttcagtcc tgcagctgaa caagaaagct ggagatttgg 3060
ccaatgaact cgtccggcac tttttgatcg agtgtacccc gaagggagtg cggttgaaag 3120
ggtgctcgaa tgaaccatat ttcgggagcc tgacggcctt ggtgtgccag cattccatca 3180
cgcccttggc cttgccgtgc aagctgctta tcccagagag agatccattg gaggaaatag 3240
cagaaagttc tccccagacg gcagccaatt cagcagctga gctgttgaag cagggggcag 3300
cctgcaacgt gtggtacttg aactctgtgg agatggagtc cctcaccggc caccaggcga 3360
tccagaaggc cctgagcatc accctggtcc aggagcctcc acctgtgtcc acagttgtgc 3420
acttcaaggt gtcagcccag ggcatcaccc tgacagacaa tcagaggaag ctcttcttcc 3480
ggaggcatta ccccgtgaac agtgtgattt tctgtgcctt ggacccacaa gacaggaagt 3540
ggatcaaaga tggcccttcc tcaaaagtct ttggatttgt ggcccggaag cagggcagtg 3600
ccacggataa tgtgtgccac ctgtttgcag agcatgaccc tgagcagcct gccagtgcca 3660
ttgtcaactt cgtatcaaag gtcatgattg gttccccaaa gaaggtctga gaactcccct 3720
ccctccctgg acccaccgat gcctctcgaa gccctggaga cagccgttgg gtgagggtgg 3780
ggcccccact ttttaccaaa ctagtaaacc tgacattcca ggcccatgag gggaaagagg 3840
atcttccagc tctgcaaaaa caagaacaaa caacatcacc gtgaattggc ctttcctgaa 3900
agtgacttat ctgacacatc tctgtagcca catgcttttt gggtagaaga agctgggcat 3960
gggtgcaccc caccccctag ggtccccatg ggaaagggac atgcaaggaa acagcacaga 4020
acacgaggtg gtccccatgt ccctggcaca ctagcattcc gggggatgag gaatccccag 4080
cccttgaggc agaggtgccg agtgactgcc atgcttcgcc cgtccgcatg ggcgcttctg 4140
tccagctgca cccgaggccg ggggtttccc tcacctcggt cttcccaaga tggagatgct 4200
aacgaaactg agaagggggc gtatgtttga cgaaggtttg tgcaagtcag gcccttctgg 4260
aacacagcag ggcctacaac gaggggcctt tgcgatgggc tgtgaggatg ggggtggtgg 4320
gaagaattgg ccacgttaga gaccccatgc caccccacca tggtgagtgc tctgtgcctc 4380
ctgctcacct gtggtgagct gggcgagctg ggcgagctgg gcgagctggg ctggggagag 4440
cctgtgagga ccgagaggag aaatgagaag aaggaacaaa aatattattt ctatgtaatt 4500
tatattttac ttatgccaaa ttatttatga taatttgcca ttgctatact gtaccagtgt 4560
caaatgctgc agcctgccaa gctgtgattt tgtgaggctt gtccctatgt aggatgcacc 4620
gcaggcccct ggccactgaa agagtgtgca gtggactgtg ggtctcccat atgcggtgcc 4680
gcccaaaggt ggctttgcct caagcaacct accctgatgt tttactcatt ggaatgtttt 4740
tccccgattg tggatgactt cttttctgat ggagagagtc caggagggat ggaaaactcc 4800
tggatttaag ctcagcatcc cccacatggg cttttcgatc atcttcaggc ctgaagctgc 4860
acgacctgaa gttcgcctgc atttatcagc cctctttgtg ctgctccttg ccaccttggg 4920
gttcctgctg gggaccatgt gtggttgtgg catgtgtgag cagaagggag gatgaggaaa 4980
aagagaagaa accccggtac tgacaagctg tttttgagtg ccactgtttg ccatcatcta 5040
agccactgaa tcaagtgtat ttcaggctta tttcaacatt ccaatgccct ggttttcctg 5100
cttgaatctg ttcgtggtca aaggtttggg ggaatttgtg accctggaac atccccagag 5160
tgaaagatgg agctgggcca catcagaata aggccttggc cccatcctct cacagcctag 5220
gtgctctgca ggcatgctga ctgtcctgat tgcgatccag cccgaaattc cctcctctgc 5280
tttcaaaagt caaatccccc attcttaggc cacactggtg tcacaagctc ctgtcaggga 5340
gctggggttt gggaatgtgc tttgtgaact ctgctttaaa gtgaggggcc gaggaaaact 5400
tagaaacagg cagagttgga agcagccaaa tcacagtggg tgttgtgtgt gtgtgcgtgt 5460
gtgcatgcgt gcgtgtatgc gtgtgtgaaa gcaggtggac cattccactt tttagctcct 5520
attgatgcac caaaccaagt gcctcatttc tgtgccaaat gtttgccttg gtcgttgtgg 5580
acctccttct ctaacttgcg gtggcatgac tgtcaggagg tgctggcatt ttcagcagat 5640
cctcatgtgt tgaccctgat gtctttagca gaggcctcta gcatctcggt ttttcatcca 5700
ctgcaggaat gtggccacag ggagcagagg tttgtacttt ccccaagagg tcctcatcct 5760
gagacggtct ctacccatgt ttaacccaaa gagtgcaggc caggttcctt atccttctga 5820
tgaaggatga gagagctcat ttagaagtca gagcaaacta gggtctcagt attgagaaac 5880
gcagcctgcc agggaatcac agagacatcg gggtgcccgc gatggccctc atgaagccat 5940
gcctcgacgg cattcaggaa gccctgcaaa cgtgcttttt gaactcattg gccaggtgtg 6000
atttttacac aaggtaaacg tggtcaaggg catcggggaa tttgctccaa gcagatagct 6060
ccctctgagg aaccaaagga agcaagtttc cacgatttct gaagagctgg tataggaagt 6120
ttctttcttc cttttgtgtt acatgtgcat taaacagaac aagctgtgtg tcatcacaga 6180
ttgtactgtg ggctcagaaa ccgtgagaga gcccccaccg tggacaccgg ctctagggcc 6240
acaggaaaag gaacgtttcc aggcattttg tctccagggc tcccgctgga caggcacgta 6300
ctgccctggg gagtaaatgc ggagagttca cgaactgtgc ccaacgcatg ttatagccag 6360
ggtcctacta actactcagt aaaagaacgt attgttgtat tcctccagtg ttaagctata 6420
gccatgttaa aagtcactgt gcatttattc tcagcatcaa ataccttgta acgtcttctc 6480
tgccttgtta gtgcatattt ttacttttct gatactgtaa agaatatatc cagtatgtaa 6540
atgaatgttc tataaatctt ttgtatagtc attttctctg ctccttaaat atcatctcta 6600
ttcagagtat aataaaatta tgaacttggt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 6660
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 6702
<210> 4
<211> 3128
<212> DNA
<213> Homo sapiens
<400> 4
gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac 60
gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg 120
tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc 180
ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct 240
aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa 300
ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag 360
catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt 420
tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga 480
attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga 540
tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc 600
cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc 660
ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt 720
agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt 780
ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca 840
gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga 900
caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa 960
ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca 1020
aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg 1080
cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga 1140
aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca 1200
caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt 1260
tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga 1320
agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc 1380
acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt 1440
catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca 1500
ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc 1560
tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct 1620
gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg 1680
gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc 1740
ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa 1800
cctggagctc aacggcagca tcctgagtgg tgggtaccct ggctcggccc ccctccagcg 1860
caacttcagc attaattctg ttgccagcac ctattctgag tttgcgaagg atccgtccct 1920
ctctgacagt tccactgttg ggcttcagcg agaactttca aaggcttcca aatctgatgc 1980
tacttctgga atcctcaatt caaccaacat ccagtcctga gaagccctga tcagtcaacc 2040
agctgtggct tcctgtgcct agactggacc taattatatg ggggtgactt tagtttttct 2100
tcagcttagg cgtgcttgaa accttggcca ggttccatga ccatgggcct aacttaaaga 2160
tgtgaatgag tgttacagtt gaaagcccat cataggttta gtggtcctag gagacttggt 2220
tttgacttat atacatgaaa agtttatggc aagaagtgca aattttagca tatggggcct 2280
gacttctcta ccacataatt ctacttgctg aagcatgatc aaagcttgtt ttatttcacc 2340
actgtaggaa aatgattgac tatgcccatc cctgggggta attttggcat gtatacctgt 2400
aactagtaat taacatcttt tttgtttagg catgttcaat taatgctgta gctatcatag 2460
ctttgctctt acctgaagcc ttgtccccac cacacaggac agccttcctc ctgaagagaa 2520
tgtctttgtg tgtccgaagt tgagatggcc tgccctactg ccaaagaggt gacaggaagg 2580
ctgggagcag ctttgttaaa ttgtgttcag ttctgttaca cagtgcattg ccctttgttg 2640
ggggtatgca tgtatgaaca cacatgcttg tcggaacgct ttctcggcgt ttgtcccttg 2700
gctctcatct cccccattcc tgtgcctact ttgcctgagt tcttctaccc ccgcagttgc 2760
cagccacatt gggagtctgt ttgttccaat gggttgagct gtctttgtcg tggagatctg 2820
gaactttgca catgtcacta ctggggaggt gttcctgctc tagcttccac gatgaggcgc 2880
cctctttacc tatcctctca atcactactc ttcttgaagc actattattt attcttccgc 2940
tgtctgcctg cagcagtact actgtcaaca tagtgtaaat ggttctcaaa agcttaccag 3000
tgtggacttg gtgttagcca cgctgtttac tcatacagta cgtgtcctgt ttttaaaata 3060
tacaattatt cttaaaaata aattaaaatc tgtatactta catttcaaaa agaaaaaaaa 3120
aaaaaaaa 3128
<210> 5
<211> 1653
<212> DNA
<213> Homo sapiens
<400> 5
agtcagcacg ggggtgctgg aagagatcgg gaataatagc gcagaccaat gagcctaggg 60
agatgctttc atcgtctctc cttccctcaa gtgttctgga acctatcatt tgaattagcc 120
gagtcaggca ggagggggcg gggaatcctt ccgcccttct taggaggggc tgcattgcag 180
ggggagagtg aactgacaga ctcagtcact gaagagggaa aaggagtgag aagacaaagc 240
cgtcaaagcc ccaacagctt tgtatttctc cagcccggcg cagaccccgg agctcccgag 300
gcactccctc catctttgga acacgccagt aattgattga taacaggaag ctatgaggga 360
ccctgtgagt agccagtaca gttcctttct tttctggagg atgcccatcc cagaactgga 420
tctgtcggag ctggaaggcc tgggtctgtc agatacagcc acctacaagg tcaaagacag 480
cagcgttggc aaaatgatcg ggcaagcaac tgcagcagac caggagaaaa accctgaagg 540
tgatggcctc cttgagtaca gcaccttcaa cttctggaga gctcccattg ccagcatcca 600
ctccttcgaa ctggacttgc tctaaggcca agacttctct ctcccatcac cttgccctca 660
ttgtcttccc tctcaagccc cttcctttcc actcctttcc cattttaatc ttgttctctc 720
cctactgtgt tggtggtgct gatgaatctg ccagagttga gttctatgta tttatttatc 780
tatctgtcta ctccatttct ctcaaaagcc ctcaagtcac aaagtaaatg gttcaagcaa 840
tggagtactg ggtcacaggg attcctcctt tcccccccaa atattaactc cagaaactag 900
gcctgactgg ggacacctga gagtagtata gtagtgcaaa atggaagact gatttttgac 960
tctattataa tcagcttcag agattcctta aaccttccta atttcctgct ccagggcagt 1020
aaacacaaat atttcttcaa ggggtgatga aaacctcgga agttttaatt tgaggttatc 1080
tgctacgaaa cagtatttct aaaaggctaa agtgataagt ctcttgcttt tttttgatcc 1140
tgctcttata ttcttttttt tcctcagaga aatcaggagg gtagttagag gtataaaaca 1200
ggaggaaata ttatggaaaa tgaaaatagg gaaaataatt gaatcatttt agaagtagct 1260
aatttctttt ctcaaaagag tgtcccttct tcacacctac tcactttaca actttgctcc 1320
taactgtggg ttgaaaactc tagctaaaga aagttatcaa atcttaacat gcattcctac 1380
tattatgata gtttttaagg tttcaattca atcttctgaa cggcataagt cctattttag 1440
ccttacctcc tgcatttgca atacgtaata ctgatcagtg ggcacagttc ttcagctaca 1500
ttgagaccct gaaatgaaca attatattct gactcgacat cttgtcccca atccttccaa 1560
aaatattgat ggtgatttgt gctaccattt actcgtttat ttaataaaga cattcaatcc 1620
cagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1653
<210> 6
<211> 3527
<212> DNA
<213> Homo sapiens
<400> 6
actgaaagct ccggtgccag accccacccc cggccccggc ccgggacccc ctcccctccc 60
gggatccccc ggggttccca ccccgcccgc accgccgggg acccggccgg tccggcgcga 120
gcccccgtcc ggggccctgg ctcggccccc aggttggagg agcccggagc ccgccttcgg 180
agctacggcc taacggcggc ggcgactgca gtctggaggg tccacacttg tgattctcaa 240
tggagagtga aaacgcagat tcataatgaa aactagcccc cgtcggccac tgattctcaa 300
aagacggagg ctgccccttc ctgttcaaaa tgccccaagt gaaacatcag aggaggaacc 360
taagagatcc cctgcccaac aggagtctaa tcaagcagag gcctccaagg aagtggcaga 420
gtccaactct tgcaagtttc cagctgggat caagattatt aaccacccca ccatgcccaa 480
cacgcaagta gtggccatcc ccaacaatgc taatattcac agcatcatca cagcactgac 540
tgccaaggga aaagagagtg gcagtagtgg gcccaacaaa ttcatcctca tcagctgtgg 600
gggagcccca actcagcctc caggactccg gcctcaaacc caaaccagct atgatgccaa 660
aaggacagaa gtgaccctgg agaccttggg accaaaacct gcagctaggg atgtgaatct 720
tcctagacca cctggagccc tttgcgagca gaaacgggag acctgtgcag atggtgaggc 780
agcaggctgc actatcaaca atagcctatc caacatccag tggcttcgaa agatgagttc 840
tgatggactg ggctcccgca gcatcaagca agagatggag gaaaaggaga attgtcacct 900
ggagcagcga caggttaagg ttgaggagcc ttcgagacca tcagcgtcct ggcagaactc 960
tgtgtctgag cggccaccct actcttacat ggccatgata caattcgcca tcaacagcac 1020
tgagaggaag cgcatgactt tgaaagacat ctatacgtgg attgaggacc actttcccta 1080
ctttaagcac attgccaagc caggctggaa gaactccatc cgccacaacc tttccctgca 1140
cgacatgttt gtccgggaga cgtctgccaa tggcaaggtc tccttctgga ccattcaccc 1200
cagtgccaac cgctacttga cattggacca ggtgtttaag ccactggacc cagggtctcc 1260
acaattgccc gagcacttgg aatcacagca gaaacgaccg aatccagagc tccgccggaa 1320
catgaccatc aaaaccgaac tccccctggg cgcacggcgg aagatgaagc cactgctacc 1380
acgggtcagc tcatacctgg tacctatcca gttcccggtg aaccagtcac tggtgttgca 1440
gccctcggtg aaggtgccat tgcccctggc ggcttccctc atgagctcag agcttgcccg 1500
ccatagcaag cgagtccgca ttgcccccaa ggtgctgcta gctgaggagg ggatagctcc 1560
tctttcttct gcaggaccag ggaaagagga gaaactcctg tttggagaag ggttttctcc 1620
tttgcttcca gttcagacta tcaaggagga agaaatccag cctggggagg aaatgccaca 1680
cttagcgaga cccatcaaag tggagagccc tcccttggaa gagtggccct ccccggcccc 1740
atctttcaaa gaggaatcat ctcactcctg ggaggattcg tcccaatctc ccaccccaag 1800
acccaagaag tcctacagtg ggcttaggtc cccaacccgg tgtgtctcgg aaatgcttgt 1860
gattcaacac agggagagga gggagaggag ccggtctcgg aggaaacagc atctactgcc 1920
tccctgtgtg gatgagccgg agctgctctt ctcagagggg cccagtactt cccgctgggc 1980
cgcagagctc ccgttcccag cagactcctc tgaccctgcc tcccagctca gctactccca 2040
ggaagtggga ggacctttta agacacccat taaggaaacg ctgcccatct cctccacccc 2100
gagcaaatct gtcctcccca gaacccctga atcctggagg ctcacgcccc cagccaaagt 2160
agggggactg gatttcagcc cagtacaaac ctcccagggt gcctctgacc ccttgcctga 2220
ccccctgggg ctgatggatc tcagcaccac tcccttgcaa agtgctcccc cccttgaatc 2280
accgcaaagg ctcctcagtt cagaaccctt agacctcatc tccgtcccct ttggcaactc 2340
ttctccctca gatatagacg tccccaagcc aggctccccg gagccacagg tttctggcct 2400
tgcagccaat cgttctctga cagaaggcct ggtcctggac acaatgaatg acagcctcag 2460
caagatcctg ctggacatca gctttcctgg cctggacgag gacccactgg gccctgacaa 2520
catcaactgg tcccagttta ttcctgagct acagtagagc cctgcccttg cccctgtgct 2580
caagctgtcc accatcccgg gcactccaag gctcagtgca ccccaagcct ctgagtgagg 2640
acagcaggca gggactgttc tgctcctcat agctccctgc tgcctgatta tgcaaaagta 2700
gcagtcacac cctagccact gctgggacct tgtgttcccc aagagtatct gattcctctg 2760
ctgtccctgc caggagctga agggtgggaa caacaaaggc aatggtgaaa agagattagg 2820
aaccccccag cctgtttcca ttctctgccc agcagtctct taccttccct gatctttgca 2880
gggtggtccg tgtaaatagt ataaattctc caaattatcc tctaattata aatgtaagct 2940
tatttcctta gatcattatc cagagactgc cagaaggtgg gtaggatgac ctggggtttc 3000
aattgacttc tgttccttgc ttttagtttt gatagaaggg aagacctgca gtgcacggtt 3060
tcttccaggc tgaggtacct ggatcttggg ttcttcactg cagggaccca gacaagtgga 3120
tctgcttgcc agagtccttt ttgcccctcc ctgccacctc cccgtgtttc caagtcagct 3180
ttcctgcaag aagaaatcct ggttaaaaaa gtcttttgta ttgggtcagg agttgaattt 3240
ggggtgggag gatggatgca actgaagcag agtgtgggtg cccagatgtg cgctattaga 3300
tgtttctctg ataatgtccc caatcatacc agggagactg gcattgacga gaactcaggt 3360
ggaggcttga gaaggccgaa agggcccctg acctgcctgg cttccttagc ttgcccctca 3420
gctttgcaaa gagccaccct aggccccagc tgaccgcatg ggtgtgagcc agcttgagaa 3480
cactaactac tcaataaaag cgaaggtgga caaaaaaaaa aaaaaaa 3527
<210> 7
<211> 2635
<212> DNA
<213> Homo sapiens
<400> 7
ggccgacgcg agcgccgcgc ttcgcttcag ctgctagctg gcccaaggga ggcgaccgcg 60
gagggtggcg aggggcggcc aggacccgca gccccggggc cgggccggtc cggaccgcca 120
gggagggcag gtcagtgggc agatcgcgtc cgcgggattc aatctctgcc cgctctgata 180
acagtccttt tccctggcgc tcacttcgtg cctggcaccc ggctgggcgc ctcaagaccg 240
ttgtctcttc gatcgcttct ttggacttgg cgaccatttc agagatgtct tccagaagta 300
ccaaagattt aattaaaagt aagtggggat cgaagcctag taactccaaa tccgaaacta 360
cattagaaaa attaaaggga gaaattgcac acttaaagac atcagtggat gaaatcacaa 420
gtgggaaagg aaagctgact gataaagaga gacacagact tttggagaaa attcgagtcc 480
ttgaggctga gaaggagaag aatgcttatc aactcacaga gaaggacaaa gaaatacagc 540
gactgagaga ccaactgaag gccagatata gtactaccgc attgcttgaa cagctggaag 600
agacaacgag agaaggagaa aggagggagc aggtgttgaa agccttatct gaagagaaag 660
acgtattgaa acaacagttg tctgctgcaa cctcacgaat tgctgaactt gaaagcaaaa 720
ccaatacact ccgtttatca cagactgtgg ctccaaactg cttcaactca tcaataaata 780
atattcatga aatggaaata cagctgaaag atgctctgga gaaaaatcag cagtggctcg 840
tgtatgatca gcagcgggaa gtctatgtaa aaggactttt agcaaagatc tttgagttgg 900
aaaagaaaac ggaaacagct gctcattcac tcccacagca gacaaaaaag cctgaatcag 960
aaggttatct tcaagaagag aagcagaaat gttacaacga tctcttggca agtgcaaaaa 1020
aagatcttga ggttgaacga caaaccataa ctcagctgag ttttgaactg agtgaatttc 1080
gaagaaaata tgaagaaacc caaaaagaag ttcacaattt aaatcagctg ttgtattcac 1140
aaagaagggc agatgtgcaa catctggaag atgataggca taaaacagag aagatacaaa 1200
aactcaggga agagaatgat attgctaggg gaaaacttga agaagagaag aagagatccg 1260
aagagctctt atctcaggtc cagtttcttt acacatctct gctaaagcag caagaagaac 1320
aaacaagggt agctctgttg gaacaacaga tgcaggcatg tactttagac tttgaaaatg 1380
aaaaactcga ccgtcaacat gtgcagcatc aattgcttgt aattcttaag gagctccgaa 1440
aagcaagaaa tcaaataaca cagttggaat ccttgaaaca gcttcatgag tttgccatca 1500
cagagccatt agtcactttc caaggagaga ctgaaaacag agaaaaagtt gccgcctcac 1560
caaaaagtcc cactgctgca ctcaatgaaa gcctggtgga atgtcccaag tgcaatatac 1620
agtatccagc cactgagcat cgcgatctgc ttgtccatgt ggaatactgt tcaaagtagc 1680
aaaataagta tttgttttga tattaaaaga ttcaatactg tattttctgt tagcttgtgg 1740
gcattttgaa ttatatattt cacattttgc ataaaactgc ctatctacct ttgacactcc 1800
agcatgctag tgaatcatgt atcttttagg ctgctgtgca tttctcttgg cagtgatacc 1860
tccctgacat ggttcatcat caggctgcaa tgacagaatg tggtgagcag cgtctactga 1920
gactactaac attttgcact gtcaaaatac ttggtgagga aaagatagct caggttattg 1980
ctaatgggtt aatgcaccag caagcaaaat attttatgtt ttgggggttt gaaaaatcaa 2040
agataattaa ccaaggatct taactgtgtt cgcatttttt atccaagcac ttagaaaacc 2100
tacaatccta attttgatgt ccattgttaa gaggtggtga tagatactat tttttttttc 2160
atattgtata gcggttatta gaaaagttgg ggattttctt gatctttatt gctgcttacc 2220
attgaaactt aacccagctg tgttccccaa ctctgttctg cgcacgaaac agtatctgtt 2280
tgaggcataa tcttaagtgg ccacacacaa tgttttctct tatgttatct ggcagtaact 2340
gtaacttgaa ttacattagc acattctgct tagctaaaat tgttaaaata aactttaata 2400
aacccatgta gccctctcat ttgattgaca gtattttagt tatttttggc attcttaaag 2460
ctgggcaatg taatgatcag atctttgttt gtctgaacag gtatttttat acatgctttt 2520
tgtaaaccaa aaacttttaa atttcttcag gttttctaac atgcttacca ctgggctact 2580
gtaaatgaga aaagaataaa attatttaat gttttaaaaa aaaaaaaaaa aaaaa 2635
<210> 8
<211> 1280
<212> DNA
<213> Homo sapiens
<400> 8
tgccgcagcc cccgcccgcc cgcagagctt ttgaaaggcg gcgggaggcg gcgagcgcca 60
tggccagtcc gggctgcctg ctgtgcgtgc tgggcctgct actctgcggg gcggcgagcc 120
tcgagctgtc tagaccccac ggcgacaccg ccaagaagcc catcatcgga atattaatgc 180
aaaaatgccg taataaagtc atgaaaaact atggaagata ctatattgct gcgtcctatg 240
taaagtactt ggagtctgca ggtgcgagag ttgtaccagt aaggctggat cttacagaga 300
aagactatga aatacttttc aaatctatta atggaatcct tttccctgga ggaagtgttg 360
acctcagacg ctcagattat gctaaagtgg ccaaaatatt ttataacttg tccatacaga 420
gttttgatga tggagactat tttcctgtgt ggggcacatg ccttggattt gaagagcttt 480
cactgctgat tagtggagag tgcttattaa ctgccacaga tactgttgac gtggcaatgc 540
cgctgaactt cactggaggt caattgcaca gcagaatgtt ccagaatttt cctactgagt 600
tgttgctgtc attagcagta gaacctctga ctgccaattt ccataagtgg agcctctccg 660
tgaagaattt tacaatgaat gaaaagttaa agaagttttt caatgtctta actacaaata 720
cagatggcaa gattgagttt atttcaacaa tggaaggata taagtatcca gtatatggtg 780
tccagtggca tccagagaaa gcaccttatg agtggaagaa tttggatggc atttcccatg 840
cacctaatgc tgtgaaaacc gcattttatt tagcagagtt ttttgttaat gaagctcgga 900
aaaacaacca tcattttaaa tctgaatctg aagaggagaa agcattgatt tatcagttca 960
gtccaattta tactggaaat atttcttcat ttcagcaatg ttacatattt gattgaaagt 1020
cttcaatttg ttaacagagc aaatttgaat aattccatga ttaaactgtt agaataactt 1080
gctactcatg gcaagattag gaagtcacag attcttttct ataatgtgcc tggctctgat 1140
tcttcattat gtatgtgact atttatataa cattagataa ttaaatagtg agacataaat 1200
agagtgcttt ttcatggaaa agccttctta tatctgaaga ttgaaaaata aatttactga 1260
aatacaaaaa aaaaaaaaaa 1280
<210> 9
<211> 1449
<212> DNA
<213> Homo sapiens
<400> 9
gacatgacac cagtggcata tcacggccat ggggtctcag cattccgctg ctgctcgccc 60
ctcctcctgc aggcgaaagc aagaagatga cagggacggt ttgctggctg aacgagagca 120
ggaagaagcc attgctcagt tcccatatgt ggaattcacc gggagagata gcatcacctg 180
tctcacgtgc caggggacag gctacattcc aacagagcaa gtaaatgagt tggtggcttt 240
gatcccacac agtgatcaga gattgcgccc tcagcgaact aagcaatatg tcctcctgtc 300
catcctgctt tgtctcctgg catctggttt ggtggttttc ttcctgtttc cgcattcagt 360
ccttgtggat gatgacggca tcaaagtggt gaaagtcaca tttaataagc aagactccct 420
tgtaattctc accatcatgg ccaccctgaa aatcaggaac tccaacttct acacggtggc 480
agtgaccagc ctgtccagcc agattcagta catgaacaca gtggtcagta catatgtgac 540
tactaacgtc tcccttattc cacctcggag tgagcaactg gtgaatttta ccgggaaggc 600
cgagatggga ggaccgtttt cctatgtgta cttcttctgc acggtacctg agatcctggt 660
gcacaacata gtgatcttca tgcgaacttc agtgaagatt tcatacattg gcctcatgac 720
ccagagctcc ttggagacac atcactatgt ggattgtgga ggaaattcca cagctattta 780
acaactgcta ttggttcttc cacacagcgc ctgtagaaga gagcacagca tatgttccca 840
aggcctgagt tctggaccta cccccacgtg gtgtaagcag aggaggaatt ggttcactta 900
actcccagca aacatcctcc tgccacttag gaggaaacac ctccctatgg taccatttat 960
gtttctcaga accagcagaa tcagtgccta gcctgtgccc agcaaatagt tggcactcaa 1020
taaagatttg cagaatttaa tacagatctt ttcagctgtt cttagggcat tataaatgga 1080
aatcataacg tggttctagg ttatcaaacc atggagtgat gtggagctag gattgtgagt 1140
gacctgcagg ccattatcag tgcctcatct gtgcagaagt ggcagcagag agggaccatc 1200
caaataccta agagaaaaca gacctagtca ggatatgaat ttgtttcagc tgttcccaaa 1260
ggcctgggag ctttttgaaa agaaagaaaa aagtgtgttg gctttttttt ttttttagaa 1320
agttagaatt gtttttacca agagtctatg tggggcttga ttcacccttc atccattggc 1380
tggaacatgg attggggatt tgatagaaaa ataaaccctg cttttgattc aaaaaaaaaa 1440
aaaaaaaaa 1449
<210> 10
<211> 945
<212> DNA
<213> Homo sapiens
<400> 10
ctgggtgtac agcgtcctcg aaaccacgag caagtgagca gatcctccga ggcaccaggg 60
actccagccc atgccatggc ggattctgag cgcctctcgg ctcctggctg ctgggccgcc 120
tgcaccaact tctcgcgcac tcgaaaggga atcctcctgt ttgctgagat tatattatgc 180
ctggtgatcc tgatctgctt cagtgcctcc acaccaggct actcctccct gtcggtgatt 240
gagatgatcc ttgctgctat tttctttgtt gtctacatgt gtgacctgca caccaagata 300
ccattcatca actggccctg gagtgatttc ttccgaaccc tcatagcggc aatcctctac 360
ctgatcacct ccattgttgt ccttgttgag agaggaaacc actccaaaat cgtcgcaggg 420
gtactgggcc taatcgctac gtgcctcttt ggctatgacg cctatgtcac cttccccgtt 480
cggcagccaa gacatacagc agcccccact gaccccgcag atggcccggt gtaggcgaac 540
ttccctcatt tctctctgca atctgcaaat aactcctcca ttgaaataac tcctccccac 600
cccaacaaca acattcccag cagaccaact cccaccccct ctttgaggta aaagtgcctt 660
tattgggaga cttttgtctt ccagcctgcc aatcaaccct cctgggtgtg gccaccatat 720
gtgtgtgcct aggtcctcct tctgcacgat ccaataggag acaccagttc tgactgaacc 780
atgcccccac ctaagtcaca aaatgaggga agtggggagt tagatttcag agtccaggcc 840
ctaggttggg acccactcca aataatctcc tcggtgtggg tggtggttct atagagggat 900
aaatgaataa taaacattgt taaaatataa aaaaaaaaaa aaaaa 945
<210> 11
<211> 4574
<212> DNA
<213> Homo sapiens
<400> 11
ggcggctgct cccattgagc tgtctgctcg ctgtgcccgc tgtgcctgct gtgcccgcgc 60
tgtcgccgct gctaccgcgt ctgctggacg cgggagacgc cagcgagctg gtgattggag 120
ccctgcggag agctcaagcg cccagctctg cccgaggagc ccaggctgcc ccgtgagtcc 180
catagttgct gcaggagtgg agccatgagc tgcgtcctgg gtggtgtcat ccccttgggg 240
ctgctgttcc tggtctgcgg atcccaaggc tacctcctgc ccaacgtcac tctcttagag 300
gagctgctca gcaaatacca gcacaacgag tctcactccc gggtccgcag agccatcccc 360
agggaggaca aggaggagat cctcatgctg cacaacaagc ttcggggcca ggtgcagcct 420
caggcctcca acatggagta catgacctgg gatgacgaac tggagaagtc tgctgcagcg 480
tgggccagtc agtgcatctg ggagcacggg cccaccagtc tgctggtgtc catcgggcag 540
aacctgggcg ctcactgggg caggtatcgc tctccggggt tccatgtgca gtcctggtat 600
gacgaggtga aggactacac ctacccctac ccgagcgagt gcaacccctg gtgtccagag 660
aggtgctcgg ggcctatgtg cacgcactac acacagatag tttgggccac caccaacaag 720
atcggttgtg ctgtgaacac ctgccggaag atgactgtct ggggagaagt ttgggagaac 780
gcggtctact ttgtctgcaa ttattctcca aaggggaact ggattggaga agccccctac 840
aagaatggcc ggccctgctc tgagtgccca cccagctatg gaggcagctg caggaacaac 900
ttgtgttacc gagaagaaac ctacactcca aaacctgaaa cggacgagat gaatgaggtg 960
gaaacggctc ccattcctga agaaaaccat gtttggctcc aaccgagggt gatgagaccc 1020
accaagccca agaaaacctc tgcggtcaac tacatgaccc aagtcgtcag atgtgacacc 1080
aagatgaagg acaggtgcaa agggtccacg tgtaacaggt accagtgccc agcaggctgc 1140
ctgaaccaca aggcgaagat ctttggaact ctgttctatg aaagctcgtc tagcatatgc 1200
cgcgccgcca tccactacgg gatcctggat gacaagggag gcctggtgga tatcaccagg 1260
aacgggaagg tccccttctt cgtgaagtct gagagacacg gcgtgcagtc cctcagcaaa 1320
tacaaacctt ccagctcatt catggtgtca aaagtgaaag tgcaggattt ggactgctac 1380
acgaccgttg ctcagctgtg cccgtttgaa aagccagcaa ctcactgccc aagaatccat 1440
tgtccggcac actgcaaaga cgaaccttcc tactgggctc cggtgtttgg aaccaacatc 1500
tatgcagata cctcaagcat ctgcaagaca gccgtgcacg cgggagtcat cagcaacgag 1560
agtgggggtg acgtggacgt gatgcccgtg gataaaaaga agacctacgt gggctcgctc 1620
aggaatggag ttcagtctga aagcctgggg actcctcggg atggaaaggc cttccggatc 1680
tttgctgtca ggcagtgaat ttccagcacc aggggagaag gggcgtcttc aggagggctt 1740
cggggttttg cttttatttt tattttgtca ttgcggggta tatggagagt caggaaactt 1800
cctttgactg atgttcagtg tccatcactt tgtggcctgt gggtgaggtg acatctcatc 1860
ccctcactga agcaacagca tcccaaggtg ctcagccgga ctccctggtg cctgatcctg 1920
ctggggcccg ggggtctcca tctggacgtc ctctctcctt tagagatctg agctgtctct 1980
taaaggggac agttgcccaa aatgttcctt gctatgtgtt cttctgttgg tggaggaagt 2040
tgatttcaac ctccctgcca aaagaacaaa ccatttgaag ctcacaattg tgaagcattc 2100
acggcgtcgg aagaggcctt ttgagcaagc gccaatgagt ttcaggaatg aagtagaagg 2160
tagttattta aaaataaaaa acacagtccg tccctaccaa tagaggaaaa tggttttaat 2220
gtttgctggt cagacagaca aatgggctag agtaagaggg ctgcgggtat gagagacccc 2280
ggctccgccc tggcacgtgt ccttgctggc ggcccgccac aggccccctt caatggccgc 2340
attcaggatg gctctataca cagcagtgct ggtttatgta gagttcagca gtcacttcag 2400
agatgtatct tgtctttgtc aggcccttca tcttcatggc ccacctgttt tctgccgtga 2460
cctttggtcc cattgaggac taaggatcgg gaccctttct ttacccccta cccattgtgg 2520
ctcccaccct gcctcggact ggtttacgtg tcctggttca cacccaggac ttttctttgc 2580
aagcgaacct gtttgaagcc caagtcttaa ctcctggtct cgtaaggttc cactgagacg 2640
agatgtctga gaacaaccaa agaaggcctg ctctttgctg cttttaaaaa atgacaatta 2700
aatgtgcaga ttccccacgc acccgatgac ctattttttc agccgtggga ggaatggagt 2760
ctttggtaca ttcctcaccg aggttagcag ctcagtttgt ggttatgaaa ccgtctgtgg 2820
cctcatgaca gcgagagatg ggaatacact agaaggatct cttttcctgt tttcgtgaaa 2880
cgactcttgc caaacgttcc cgaggcgcca aggagtgtag tacaccctgg ctgccatcac 2940
tctataaaag tgcttcatga gcccagacca aaagcccaca gtgaaatgaa gtaccctttt 3000
gtaaatagca tttttttgca gaaggtgaaa attccactct ctaccaccgg gccagccaat 3060
agatcacttt ggtgaatgct agtttcaaat ttgattcaaa atatttctta ggtgaaagaa 3120
ctagcagaaa gtcaaaaact aagatactgt agactggaca agaaattcta cctgggcacc 3180
taggtgatgc cttctttctt tgattgcctt tctaataaat gcagaatctg aaggtaaata 3240
ggtttaaaac aaaacaaaaa cccacccctt taaggagttg gtaaaaagca gttcaactct 3300
tagcttgact gagctaaaat tcacaggact acgtgctttg tgcattgtag tctagtcgta 3360
attcataggt actgactcct cagccccaaa tgtcggagag gaagaattcg gtcagcctgt 3420
caggtcgtga gtccagttac caccaaacat ctgggaaact tctgggtgct gggtgctctg 3480
ctgctggact tttgtggctg tgtctgtgtc tgcaagataa attagatcgc cctgtggggt 3540
ttgcagaatt agtgaagggt ccaggacgat cccagtgggc tcgcttccaa agcatcccac 3600
tcaagggaga cttgaaactt ccagtgtgag ttgaccccat catttaaaaa taaagtcccc 3660
gggttcctta atgcctcctt cactgggcct tcctagcagg atagaaagtc cttgcccaga 3720
gcaggacctg gctgtctttt tttttttttt tttcccgaga ccaagtttca ctctgttgcc 3780
caaggtagag tgcagtggcg tgatctctgc tcattgcaac tgccgcctcc cgggttcaag 3840
caattctcat gcatcagcct cccaagtacc tgggactaca ggcgtgagct accatgcccg 3900
gctaattttt gtatttttag tagagatggg gtttcattat gttggccagg ctggtctcga 3960
actccttacc tcaggtgatc cacccacctt ggcctcccga agtgctggga ttacaggcat 4020
gagccactgc gcccggccat ggacctggct gtctttatca tccccacaaa cattttgaaa 4080
ctggaatatt tgtcttcaga aaatggaaac aagactataa atgataagcc ctgtccctag 4140
caccacctct cctgtgtgtg gaatagaggc ccctcgtgct accaacactt accctgtgtt 4200
taaaaagatc ttgtaccaag ccaacggcgt tcctggctct cctgcccaca ggatgaacat 4260
tttcggcttc cttaggagtt ttgccctacc gtattccaaa gcgtgtgctg gtttctcata 4320
ttgtctgtag gctcactcag cccgcagttt atgtgtgtgc ttttttctat gaaaaatgat 4380
gtattttgct acttcctgtg tacaaagttt tattgtaaat gttttttgtg ctttgcatga 4440
acaggggcca cgttgttgca attgtttcag tagaactggt ttgatttcta aaatgttcct 4500
gtaacatatc ttttatgaac aaatctgaac aatttgtgaa ataaaacatt gaaaaccaaa 4560
aaaaaaaaaa aaaa 4574
<210> 12
<211> 3414
<212> DNA
<213> Homo sapiens
<400> 12
gcttacacag tatggccggc gacattagct agcgctcgct ctactctctc taacgggaaa 60
gcagcggaat acaagagact gaactgtatc tgcctctatt tccaaaagac tcacgttcaa 120
ctttcgctca cacaaagccg ggaaaatttt attagtcctt tttttaaaaa aagttaatat 180
aaaattatag caaaaaaaaa aaggaacctg aactttagta acacagctgg aacaatcgca 240
gcggcggcgg cagcggcggg agaagaggtt taatttagtt gattttctgt ggttgttggt 300
tgttcgctag tctcacggtg atggaagctg cacatttttt cgaagggacc gagaagctgc 360
tggaggtttg gttctcccgg cagcagcccg acgcaaacca aggatctggg gatcttcgca 420
ctatcccaag atctgagtgg gacatacttt tgaaggatgt gcaatgttca atcataagtg 480
tgacaaaaac tgacaagcag gaagcttatg tactcagtga gagtagcatg tttgtctcca 540
agagacgttt cattttgaag acatgtggta ccaccctctt gctgaaagca ctggttcccc 600
tgttgaagct tgctagggat tacagtgggt ttgactcaat tcaaagcttc ttttattctc 660
gtaagaattt catgaagcct tctcaccaag ggtacccaca ccggaatttc caggaagaaa 720
tagagtttct taatgcaatt ttcccaaatg gagcaggata ttgtatggga cgtatgaatt 780
ctgactgttg gtacttatat actctggatt tcccagagag tcgggtaatc agtcagccag 840
atcaaacctt ggaaattctg atgagtgagc ttgacccagc agttatggac cagttctaca 900
tgaaagatgg tgttactgca aaggatgtca ctcgtgagag tggaattcgt gacctgatac 960
caggttctgt cattgatgcc acaatgttca atccttgtgg gtattcgatg aatggaatga 1020
aatcggatgg aacttattgg actattcaca tcactccaga accagaattt tcttatgtta 1080
gctttgaaac aaacttaagt cagacctcct atgatgacct gatcaggaaa gttgtagaag 1140
tcttcaagcc aggaaaattt gtgaccacct tgtttgttaa tcagagttct aaatgtcgca 1200
cagtgcttgc ttcgccccag aagattgaag gttttaagcg tcttgattgc cagagtgcta 1260
tgttcaatga ttacaatttt gtttttacca gttttgctaa gaagcagcaa caacagcaga 1320
gttgattaag aaaaatgaag aaaaaacgca aaaagagaac acatgtagaa ggtggtggat 1380
gctttctaga tgtcgatgct gggggcagtg ctttccataa ccaccactgt gtagttgcag 1440
aaagccctag atgtaatgat agtgtaatca ttttgaattg tatgcattat tatatcaagg 1500
agttagatat cttgcatgaa tgctctcttc tgtgtttagg tattctctgc cactcttgct 1560
gtgaaattga agtggatgta gaaaaaacct tttactatat gaaactttac aacacttgtg 1620
aaagcaactc aatttggttt atgcacagtg taatatttct ccaagtatca tccaaaattc 1680
cccacagaca aggctttcgt cctcattagg tgttggcctc agcctaaccc tctaggactg 1740
ttctattaaa ttgctgccag aattttacat ccagttacct ccactttcta gaacatattc 1800
tttactaatg ttattgaaac caatttctac ttcatactga tgtttttgga aacagcaatt 1860
aaagtttttc ttccatagtt gagtccttag aaaatgattc cagttactca ttttgcatat 1920
tgctatttaa cattattgga ccctgcattt atagtccttt gatttcttcc ctctccctgg 1980
tgtctccccc aagaccccaa ataaagcaat accctgttaa cactgtgggt ttatatacta 2040
attctatacc ccagatgggg aattaggggg gagatggtcc ctgggcttaa tattctttaa 2100
agggcatggg aatttagcct ctcttttatt gtaatgtgct cttttggaaa atagttggtt 2160
agcagggaga ccagagttgt agattgagat tgggtgtact ggctgttctg tggaaaacat 2220
acattctgtg ttcctcgaat aagtgaaatt gagcttctaa tgagatgcac ccctttacta 2280
acttgatgat gatataaaat tcatttttat ttagttaatt accagagaga tttagcataa 2340
ttttgcttct ggattcagta aatcaagtca gcttggatca ttcaccttaa cttttccttt 2400
agcagccctt tccactagtt tcccattaag tagtgttcta taaactttga tccaaagcag 2460
aatcaatgtc ttttccatct cgtgacttaa agttctgtga ctgtgatgca tgtgagtgtt 2520
ccgacttcat ctgttcctct taactacggt gtttccctta ccgatcggca ttcataggat 2580
gaaatgaatg actgtcccag aatgagaatt tgtccagatt attcagataa acatcataaa 2640
gagaataaca ttataaataa gtagaatatg aataaataga ataataaaat tccaaaatac 2700
tcaatgggaa atgactagta atataggctt tcaagagttg gtacctttac gtatatttgc 2760
agattctctg ggattttaag gaactgagaa aacagaaaag ttgactaaat tttatatttc 2820
ttgtcctcta aatattttga taatttctgg attgatgcag tgatgttttt cgttccttgt 2880
atttataaat gaaaaccttt ttttggtgtt tctaaaccta aaatctactt ggtttgaaat 2940
caagtggttg gaacactgtt tgacttttat ttgaagcatg ttgttgattg aaaatttcat 3000
tgaggaagtt ttcaatcagt gtgatcagtt tgattctgta atgagcacag cacctaatat 3060
tttgaggagc tctgttttga ggaccaatgc ttaaggtgga ccttgttgct aaacaatatc 3120
ccaatagatt tgttgacttg aggtctggtt tggttttgtt tttgttttgt tttggttttg 3180
ttttgtttcc caatagaatt aagaattcta atgttgaaaa actgtataaa tttttatggg 3240
acaaagccta gaaaagagaa atgtagtttg aatcataatc taaatcatcg tatgatagga 3300
aggaaaagtt ttggtgccat aatttctcct ttcactggtg ttggacttaa atcagttgaa 3360
atgtatttct gtaccacaat ttacgcttca ataaaagttt aattgtctag tgag 3414
<210> 13
<211> 1558
<212> DNA
<213> Homo sapiens
<400> 13
gagtgcaaag cgctctccct ccctcgccca gccttcgtcc tcctggcccg ctcctctcat 60
ccctcccatt ctccatttcc cttccgttcc ctccctgtca gggcgtaatt gagtcaaagg 120
caggatcagg ttccccgcct tccagtccaa aaatcccgcc aagagagccc cagagcagag 180
gaaaatccaa agtggagaga ggggaagaaa gagaccagtg agtcatccgt ccagaaggcg 240
gggagagcag cagcggccca agcaggagct gcagcgagcc gggtacctgg actcagcggt 300
agcaacctcg ccccttgcaa caaaggcaga ctgagcgcca gagaggacgt ttccaactca 360
aaaatgcagg ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca 420
ttcattttca tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa 480
aaaaaagtga agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt 540
ggagactgtg ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc 600
atgaagaccc agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc 660
aaataccagt tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact 720
ggaagtctga agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag 780
ccctgtggca aactgaccaa gcccaaacct caagcagaat ctaagaagaa gaaaaaggaa 840
ggcaagaaac aggagaagat gctggattaa aagatgtcac ctgtggaaca taaaaaggac 900
atcagcaaac aggatcagtt aactattgca tttatatgta ccgtaggctt tgtattcaaa 960
aattatctat agctaagtac acaataagca aaaacaaaaa gaaaagaaaa tttttgtagt 1020
agcgtttttt aaatgtatac tatagtacca gtaggggctt ataataaagg actgtaatct 1080
tatttaggaa gttgacttat agtacatgat aaatgataga caattgaggt aagttttttg 1140
aaattatgtg acattttaca ttaaattttt tttacatttt ttgggcagca atttaaatgt 1200
tatgactatg taaactactt ctcttgttag gtaatttttt tcacctagat ttttttccca 1260
attgagaaaa atatatacta aacaaaatag caataaaaca taatcactct atttgaagaa 1320
aatatcttgt tttctgccaa tagatttttt aaaatgtagt cagcaaaatg ggggtgggga 1380
agcagagcat gtcctagttc aatgttgact tttttttttt ttaaagaaaa gcattaagac 1440
ataaaattct ttcactttgg cagaagcatt tgttttcttg atgaaattat ttttccatct 1500
gaggaaaaaa atactaggaa aataaatcaa ggtgatgctg aaaaaaaaaa aaaaaaaa 1558
<210> 14
<211> 1416
<212> DNA
<213> Homo sapiens
<400> 14
acgggctatt taaaggtacg cgccgcggcc aaggccgcac cgtactgggc gggggtctgg 60
ggagcgcagc agccatggca agccgtctcc tgctcaacaa cggcgccaag atgcccatcc 120
tggggttggg tacctggaag tcccctccag ggcaggtgac tgaggccgtg aaggtggcca 180
ttgacgtcgg gtaccgccac atcgactgtg cccatgtgta ccagaatgag aatgaggtgg 240
gggtggccat tcaggagaag ctcagggagc aggtggtgaa gcgtgaggag ctcttcatcg 300
tcagcaagct gtggtgcacg taccatgaga agggcctggt gaaaggagcc tgccagaaga 360
cactcagcga cctgaagctg gactacctgg acctctacct tattcactgg ccgactggct 420
ttaagcctgg gaaggaattt ttcccattgg atgagtcggg caatgtggtt cccagtgaca 480
ccaacattct ggacacgtgg gcggccatgg aagagctggt ggatgaaggg ctggtgaaag 540
ctattggcat ctccaacttc aaccatctcc aggtggagat gatcttaaac aaacctggct 600
tgaagtataa gcctgcagtt aaccagattg agtgccaccc atatctcact caggagaagt 660
taatccagta ctgccagtcc aaaggcatcg tggtgaccgc ctacagcccc ctcggctctc 720
ctgacaggcc ctgggccaag cccgaggacc cttctctcct ggaggatccc aggatcaagg 780
cgatcgcagc caagcacaat aaaactacag cccaggtcct gatccggttc cccatgcaga 840
ggaacttggt ggtgatcccc aagtctgtga caccagaacg cattgctgag aactttaagg 900
tctttgactt tgaactgagc agccaggata tgaccacctt actcagctac aacaggaact 960
ggagggtctg tgccttgttg agctgtacct cccacaagga ttaccccttc catgaagagt 1020
tttgaagctg tggttgcctg ctcgtcccca agtgacctat acctgtgttt cttgcctcat 1080
ttttttcctt gcaaatgtag tatggcctgt gtcactcagc agtgggacag caacctgtag 1140
agtggccagc gagggcgtgt ctagcttgat gttggatctc aagagccctg tcagtagagt 1200
agaagtctct tccagtttgc tttgcccttc tttctaccct gctggggaaa gtacaacctg 1260
aatacccttt tctgaccaaa gagaagcaaa atctaccagg tcaaaatagt gccactaacg 1320
gttgagtttt gactgcttgg aactggaatc ctttcagcaa gacttctctt tgcctcaaat 1380
aaaaagtgct tttgtgagaa aaaaaaaaaa aaaaaa 1416
<210> 15
<211> 6400
<212> DNA
<213> Homo sapiens
<400> 15
ctgagatgca ggcccagcgc tggcgcagtg agaacttcga gagacccgtg gacctggagg 60
gctctgggga tgatgactcc tttcccgatg atgaactgga tgacctctac tcggggtcgg 120
gctcgggctg taagtacccc cctccctacc tctgcctggg ggcagtgacc agtctgtatc 180
cagcctcaac tctgagaagc ccacgggggg cttgcttcag tgaggcaggg ggcattcact 240
gcctgggtca ggcaagttct tcttgctctg gatccccaga acaagaaggg cagaacatcc 300
ttctggggat agaacaagac ctgggaggac ctcagggccc agaatgtcca ggtctccagg 360
gtcccacgtc tgcatctttg tgtgtgctat gtggctttct ctgcagacct tgcttggttc 420
cggtggtccc gtcaggtgca ataagctgtg gccaatggtg gggttagggc agtgatgaca 480
cagggcaggt gcttcaagtg gtgcctggga tggccccgcc ctggggaagg ggagccaggt 540
cagctgggtc tagcagaatc tcgggagaga agggcaccgc gaaccccact ctgccatgta 600
gcaactgtgt gcccctcggt gctccccctc cctgaatccc tgtattttca cctgtggatg 660
gtgagaaata cgacttcttc tcagtgcctc taggagggtt tgggatagga agctggggtc 720
tggcacagag gaggagctct caaaatggta gcaaaaagaa ggcagctgag actgggccca 780
gtgagggcac gggctggcat ctgaggagat ggtacggggt ctgcacgcca cagagctggc 840
tccccacagc cctcgcctct ggtctcccct ccttagccaa gtcctttgag cctctttcaa 900
attaatcttt gtaaaacccg tttatattgg gtcacatctc tattcgcaaa gttccctggc 960
tcccctccct cctgcctggt tccgagccca ggagctggct gtggcttctc cctcccccat 1020
cccctactcc ccgtctcatt tcctcccaag ttccttcact gtcccggctt tgcgtcagcc 1080
agattgctca agcagttccc ctgcctcaag ggcttctttt cccttttacc ctccgcctct 1140
gcctctgggg gaagccctta gtgtaccacc cctgccttga gcttgtggta ggggtgcctt 1200
tggggtctga ctcttcccag aatgccactc ctgtgttccc ctgcaagccc cagcaagttt 1260
tgcagccagt agcgcctcag ttgctgctgc ctggattcaa cctcatagaa actgtaggct 1320
gggtgggcag gaatagtcaa ggaaggcttc ccgggagagg cggcccccag aatttttgac 1380
ttggcagaga gaagttgggg aacatcagca actgaccacc tttagctggc tgtgccttcc 1440
tcctttctct catcttttct gggaaaattg ggtaaagaga gggggttggg agacctaatc 1500
ttgatggcca ttgcttacct gggatcctca tgcccctcac aaccacccag ctccctagct 1560
ctctccctct cccccacccc ctcagacttc gagcaggagt cgggcattga gacagccatg 1620
cgcttcagcc cagatgtagc cctggcggtg tccaccacac ctgcggtgct gcccaccacg 1680
aacatccagc ctgtgggcac accatttgaa gagctcccct ctgagcgccc caccctggag 1740
ccagccacca gccccctggt ggtgacagaa gtcccggaag agcccagcca gagagccacc 1800
accgtctcca ctaccatggc taccactgct gccacaagca caggggaccc gactgtggcc 1860
acagtgcctg ccacagtggc caccgccacc cccagcaccc ctgcagcacc cccttttacg 1920
gccaccactg ctgttataag gaccactggc gtacggaggc ttctgcctct cccactgacc 1980
acagtggcta cggcacgggc cactaccccc gaggcgccct ccccgcccac cacggcggct 2040
gtcttggaca ccgaggcccc aacacccagg ctggtcagca cagctacctc ccggccaaga 2100
gcccttccca ggccggccac cacccaggag cctgacatcc ctgagaggag caccctgccc 2160
ctggggacca ctgcccctgg acccacagag gtggctcaga ccccaactcc agagaccttc 2220
ctgaccacaa tccgggatga gccagaggtt ccggtgagtg gggggcccag tggagacttc 2280
gagctgccag aagaagagac cacacaacca gacacagcca atgaggtggt agctgtggga 2340
ggggctgcgg ccaaggcatc atctccacct gggacactgc ccaagggtgc ccgcccgggc 2400
cctggcctcc tggacaatgc catcgactcg ggcagctcag ctgctcagct gcctcagaag 2460
agtatcctgg agcggaagga ggtgctcgta gctgtgattg tgggcggggt ggtgggcgcc 2520
ctctttgctg ccttcttggt cacactgctc atctatcgta tgaagaaaaa ggatgagggc 2580
agctacacgc tggaggaacc caagcaggcg agcgtcacat accagaagcc tgacaagcag 2640
gaggagttct atgcctagtg gagccacagt gcctccctgc agcctcaaca ccaccctgct 2700
gtccagtccc cagcctggcc ccaccagccc aagcctggga ctgggcctgg aacctggccc 2760
cagttcttct ctgccctctc tcccaaggtc tgcccaggct gccagcctca cacagatctt 2820
ccccgaggaa gaggggctgc tgccatctgc cccagactgt gcccttacga gctcatctct 2880
tgttcccctc atccctgcca ccagtctggg gcttcaggac ctcatgtcag atggatggga 2940
ggaagaaagc tcctgattgg ctggtggtgg aagaaagggt ggggcttgag atgagcctga 3000
gccctgactt ggcacccaca gtgctcactg agatctcctt tttggggcag agaggcactc 3060
aggctggttt ccaggacaaa catttggtaa acacagccct tgaaatcatc tagacactgc 3120
aacctcttgc tcgtatccca gggcctctct ctagctgggt gagagggtgt cccttgtcac 3180
cagcctgttt tgtcctggtc tctctggggt tgttgaatct ctcctcttgc ctgccaagta 3240
cacatgtacc cagacttcat ttctttctgc atcttccccc aagaaacagc ttcctgaggg 3300
tgctggggca gccactggtg aggaggggct gctctgatgt ccctcctatg aggggactct 3360
gcacagacac cattgcccac actatcacca tattttcact cagtcacaca caagacaaaa 3420
gcatgcaatg acaaaaccat acgcaatcct gaccgcccag ccaatcaaga catatcacag 3480
aacacacgcg tccttccaag aatgtttatc ctcatgcatc acttacacac ccccagacac 3540
gtactgcaat gcaagtcact agtcatggtc acatgacagt gacagtgtgg cctcctccta 3600
ccccaaatac acccacactc tggcaccaca cacattgtct ccagctttca ggcttactgg 3660
ggagggtgga atcgagccag aacaatcagc ccatattggg tccccctaag ttgccccgtc 3720
atactcagtc ccatgccatg gtgcccacac caaccatgca gccaccaacc ccagccagtg 3780
tcagacacaa tcccatgtgg atgcacagtc tcactccaca tgacctgctc tcaatgctgg 3840
agggaaacag gcaggccctt gcctttctcg gaaaaagtgt ggggccacag cccttttagg 3900
gcattgcatg caggtgggcc tggcttcacc cctacctgct tcctccccac cgcagctggc 3960
agagggggag gtttggggcc agacccccac tagctgggag cctgggggct cctctaaggc 4020
tgaggaagga aatttggccc caggttgttg gggggtcttg ggtctcccag gacggaaggc 4080
ccagggcagg gagggggcat gtggttgggc tcctttatct ccctgtgtcc ccttcctgct 4140
ttgagctagg gggctgactc tgcctcccag gacacaagtc tccaaagtgc ctgtgagggc 4200
gggccctccg caccctctgc cctctgcctg gcaggccaac ctcagcccac ctgcccagag 4260
gccctccctg tggacacccc ctcacctatt tggccaaaca attctggctg cagcttcagg 4320
ggccatggct ggaagcagcc cctgcagatc cctcaggccc cgaggtcagg gtttgaggga 4380
tgagaccagg tgatagtggg ggaggggtta cttcctttgt tacctagcaa gtagggctat 4440
ttccatcggt attttaaatg tggggtcaca gatcttttgg ggagggtgtg cttggcaggg 4500
ggcctcttgg agccaaaggg atgtggtgtg agttgcgatt ggctggcact cacaccccca 4560
cccctcaccc acatcccaga ttcaagtcag gaaggcaggt tttatttcag ggcccttttc 4620
aagatgccct ggcagcagat ttctgcagga tgaggggtag cggtgtgtag gcagtgaggg 4680
ggaggttcca ggggctgtcc cacagcctgt cttttccagg ctgggctcca tcttccagtc 4740
ccaaaaccct ccttcacagg gcccagaggc ttgtgaggaa gccaggtgga cccagccttg 4800
gaagagtggg catggggggc ccctgatatc tggagggggc gggttggcct cagtcatctt 4860
tggagcagaa gggctgggtc ctggggccac agaccacaag gctcagcctc cctaccctgc 4920
tccctggggt gctgctgtct tggagagcac agctctggtg agacggcctg ggcaggccga 4980
ggctgagaaa ccagggagga tagaggagaa aagggcttgg gcccccagcc ccagaagatg 5040
ctgggcccca ggtgggagac ccaacagtgg gtgcagtttc tcagtggggc tggagccaat 5100
ggtgggggtg gccccggcag gcctggctcc tcacatccca ggggttggct tctgatttgg 5160
ggcttgggct ccaggcactg gcttctcttc tctgtgtcct tagcatttga gagaagaggc 5220
caggggcctt gttcatggat ccctggaccc aaggcagatg tccaggcttt atcctcctga 5280
ggatgaggag tctgaccagc ccaaatctgc cctggccggc ctgaccgggg caaggcagtc 5340
caagagagtt cagtgaggac cagctaggct ctcccaggtg caatgtgggt gcagggccct 5400
catgtccccc tacccctgcc tgtgatggag tgttctgagg ggctttggca tttgctggaa 5460
gcacagggag ttccaaatga gagggagctt ctgtggcttg agagcctctg gggccttggc 5520
tgccagagca cgaggcaggc caggacctgg agagcccaga ccctgtctcc aggaggccag 5580
gaggccagat gggggccttg cctgaaagac tggtcccctt gatcgctgga ggcatgtggg 5640
tggcaaccag ggctgggcag ggcttagggt gtgtgggcca aacccccctg gggttggcaa 5700
agccgcctgt caggcctcct ggtgggggcc cctggacaca gggagcagac cctctgcctc 5760
atggggtagg agtggctgcc tcctgtgttc tctggatttc ttctcccaac aactacaacc 5820
ctggacttgc ctccccaggc ctcttgcctg taaatagaag cccgcaaact gtacagattt 5880
acagaggcat cgagactggg ccctgggagt tgccatctga gagccgatgg ccccagcatc 5940
ccccaggtgc ctgcctggca ccacagtgac cctggcctca gcgtggcaaa tgcatgtaaa 6000
tatttttcgt aggcagcgtg gctccagaga gccccctgaa gacagtgtcc ctccctcctg 6060
tgagtccttt ctcctgtaca gaacctgcct ggggtgggtg ggggtctgcc attccctccc 6120
ccaggccttc cctgcccctt ctctcccctg taacctgttt attaaccata cctgtcctga 6180
gttcatggcc aaaaccttaa ataagaaaaa caaaagaaaa agacagtgga aaaaagagac 6240
caaggcgcct gccccactgc gggtactctc ctgttccagc cttgtgaagg aactggtttt 6300
gtttttgttt ttgttttttt tttttttgtt tgtttgtttg ttttttaaca cttcctgtgc 6360
tgtgcccatt tataagagga aataaaatta agctgaaatg 6400
<210> 16
<211> 5487
<212> DNA
<213> Homo sapiens
<400> 16
tctgtcgact tgccccagag ctgatccttg tctttgtcca cttctcagcg aggatggcac 60
ttcagggagc ccttccctta ctatcgcaga gagagcaggc cctccccagt catgtccaac 120
ccagaactct gttttgtttt cttcatagcc ctagcatcac agaaaatcac cctgtgcatt 180
catggatgtc cacgggggca agggctttgt gttgcttaac ccagcatcct gaaccgtgtt 240
tgttgaatga atacagaacc ccgtttgctc tgggagagca cagaaaacag tcttctatca 300
tatatcatag ccagctgcaa acagcagatg gcttcccata tcccagagag taagaaccag 360
agagagagag aaagagagag agtttgggtc tttctcctct gtgcctgctc tctccagaga 420
aactggaggg gtagcagtta gcattccccc gctggttcca ccaagcacag tcaaggtctc 480
taggacatgg ccacccctca cctgtggaag cggtcctgct ggggtgggtg ggtgttagtt 540
ggttctggtt tgggtcagag acacccagtg gcccaggtgg gcgtggggcc agggcgcaga 600
cgagaagggg cacgagggct ccgctccgag gacccagcgg caagcaccgg tcccgggcgc 660
gccccagccc acccactcgc gtgcccacgg cggcattatt ccctataagg atctgaacga 720
tccgggggcg gccccgcccc gttacccctt gcccccggcc ccgccccctt tttggagggc 780
cgatgaggta atgcggctct gccattggtc tgagggggcg ggccccaaca gcccgaggcg 840
gggtccccgg gggcccagcg ctatatcact cggccgccca ggcagcggcg cagagcgggc 900
agcaggcagg cggcgggcgc tcagacggct tctcctcctc ctcttgctcc tccagctcct 960
gctccttcgc cgggaggccg cccgccgagt cctgcgccag cgccgaggca gcctcgctgc 1020
gccccatccc gtcccgccgg gcactcggag ggcagcgcgc cggaggccaa ggttgccccg 1080
cacggcccgg cgggcgagcg agctcgggct gcagcagccc cgccggcggc gcgcacggca 1140
actttggaga ggcgagcagc agccccggca gcggcggcag cagcggcaat gaccccttgg 1200
ctcgggctca tcgtgctcct gggcagctgg agcctggggg actggggcgc cgaggcgtgc 1260
acatgctcgc ccagccaccc ccaggacgcc ttctgcaact ccgacatcgt gatccgggcc 1320
aaggtggtgg ggaagaagct ggtaaaggag gggcccttcg gcacgctggt ctacaccatc 1380
aagcagatga agatgtaccg aggcttcacc aagatgcccc atgtgcagta catccacacg 1440
gaagcttccg agagtctctg tggccttaag ctggaggtca acaagtacca gtacctgctg 1500
acaggtcgcg tctatgatgg caagatgtac acggggctgt gcaacttcgt ggagaggtgg 1560
gaccagctca ccctctccca gcgcaagggg ctgaactatc ggtatcacct gggttgtaac 1620
tgcaagatca agtcctgcta ctacctgcct tgctttgtga cttccaagaa cgagtgtctc 1680
tggaccgaca tgctctccaa tttcggttac cctggctacc agtccaaaca ctacgcctgc 1740
atccggcaga agggcggcta ctgcagctgg taccgaggat gggccccccc ggataaaagc 1800
atcatcaatg ccacagaccc ctgagcgcca gaccctgccc cacctcactt ccctcccttc 1860
ccgctgagct tcccttggac actaactctt cccagatgat gacaatgaaa ttagtgcctg 1920
ttttcttgca aatttagcac ttggaacatt taaagaaagg tctatgctgt catatggggt 1980
ttattgggaa ctatcctcct ggccccaccc tgccccttct ttttggtttt gacatcattc 2040
atttccacct gggaatttct ggtgccatgc cagaaagaat gaggaacctg tattcctctt 2100
cttcgtgata atataatctc tattttttta ggaaaacaaa aatgaaaaac tactccattt 2160
gaggattgta attcccaccc ctcttgcttc ttccccacct caccatctcc cagaccctct 2220
tccctttgcc cttctcctcc aatacataaa ggacacagac aaggaacttg ctgaaaggcc 2280
aaccatttca ggatcagtca aaggcagcaa gcagatagac tcaaggtgtg tgaaagatgt 2340
tatacaccag gagctgccac tgcatgtccc aaccagactg tgtctgtctg tgtctgcatg 2400
taagagtgag ggagggaagg aaggaactac aagagagtcg gagatgatgc agcacacaca 2460
caattcccca gcccagtgat gcttgtgttg accagatgtt cctgagtctg gagcaagcac 2520
ccaggccaga ataacagagc tttcttagtt ggtgaagact taaacatctg cctgaggtca 2580
ggaggcaatt tgcctgcctt gtacaaaagc tcaggtgaaa gactgagatg aatgtctttc 2640
ctctccctgc ctcccaccag acttcctcct ggaaaacgct ttggtagatt tggccaggag 2700
ctttctttta tgtaaattgg ataaatacac acaccataca ctatccacag atatagccaa 2760
gtagatttgg gtagaggata ctatttccag aatagtgttt agctcaccta gggggatatg 2820
tttgtataca catttgcata tacccacatg gggacataag ctaatttttt tacaggacac 2880
agaattctgt tcaatgctgt taaatatgcc aatagtttaa tctcttctat tttgttgtcg 2940
ttgcttgttt gaagaaaatc atgacattcc aagttgacat ttttttttca ttttaattaa 3000
aatttgaaat tctgaacacc gtcagcaccc tctcttccct atcatgggtc atctgacccc 3060
tgtccgtctc cttgtccctg cttcatgttt gggggccttt ctttaactgc cttcctggct 3120
tagctcagat ggcagatgag agtgtagtca agggcctggg cacaggaggg agagctgcag 3180
agtgtcctgc ctgccttggc tggagggaca cctctcctgg gtgtggagac agcttggttc 3240
cctttcccta gctccctggt gggtgaatgc cacctcctga gatcctcacc tcttggaatt 3300
aaaattgttg gtcactgggg aaagcctgag tttgcaacca gttgtagggt ttctgttgtg 3360
tttttttttt tttttttgaa ataaaactat aatataaatt ctcctattaa ataaaattat 3420
tttaagtttt agtgtcaaaa gtgagatgct gagagtaggt gataatgtat attttacaga 3480
gtgggggttg gcaggatggt gacattgaac atgattgctc tctgtctctt ttttcagctt 3540
atgggtattt atcttctatt agtatttgta tcttcagttc attccacttt aggaaacaga 3600
gctgccaatt gaaacagaag aagaaaaaaa aaaaaagcag cagacaacac actgtagagt 3660
cttgcacaca cacaagtgcc caggcaaggt gcttggcaga accgcagagt gggaagagag 3720
taccggcatc gggtttcctt gggatcaatt tcattaccgt gtacctttcc cattgtggtc 3780
atgccatttg gcagggggag aatgggaggc ttggccttct ttgtgaggca gtgtgagcag 3840
aagctgatgc cagcatgtca ctggttttga agggatgagc ccagacttga tgttttggga 3900
ttgtccttat tttaacctca aggtctcgca tggtggggcc cctgaccaac ctacacaagt 3960
tccctcccac aagtggacat cagtgtcttc tctgtgaggc atctggccat tcgcactccc 4020
tggtgtggtc agcctctctc acacaaggag gaacttgggt gaaggctgag tgtgaggcac 4080
ctgaagtttc cctgcggagt cgataaatta gcagaaccac atccccatct gttaggcctt 4140
ggtgaggagg ccctgggcaa agaagggtct ttcgcaaagc gatgtcagag ggcggttttg 4200
agctttctat aagctatagc tttgtttatt tcacccgttc acttactgta taatttaaaa 4260
tcatttatgt agctgagaca cttctgtatt tcaatcatat catgaacatt ttattttgct 4320
aaatcttgtg tcatgtgtag gctgtaatat gtgtacattg tgtttaagag aaaaatgaaa 4380
cccacatgcc gccattttcc tgaatcaaat tctgcagtgg aatggagagg aaaatacttc 4440
taggcaagca gctagactgg tgaattgggg gaaatagaag gaactagtaa ctgagactcc 4500
tccagcctcc tccctattgg aatcccaatg gctcctggag taggaaaaaa gtttaaacta 4560
cattcatgtt cttgttctgt gtcactcggc cctgggtagt ctaccattta cttcacccca 4620
agtcctgctg cccatccagt tgggaagcca tgattttcct aagaatccag ggccatggga 4680
gatacaattc caagttctcg cttcctcctt tgggcatctc ttctgcctcc caatcaagga 4740
agctccatgc tcaggctctc agctctcggg ccagtgctct gctctgtcca gggtaggtaa 4800
tactgggaga ctcctgtctt ttaccctccc ctcgttccag acctgcctca tggtggcaac 4860
atggttcttg aacaattaaa gaaacaaatg actttttgga atagccctgt ctagggcaaa 4920
ctgtggcccc caggagacac tacccttcca tgccccagac ctctgtcttg catgtgacaa 4980
ttgacaatct ggactacccc aagatggcac ccaagtgttt ggcttctggc tacctaaggt 5040
taacatgtca ctagagtatt tttatgagag acaaacatta taaaaatctg atggcaaaag 5100
caaaacaaaa tggaaagtag gggaggtgga tgtgacaaca acttccaaat tggctctttg 5160
gaggcgagag gaaggggaga acttggagaa tagtttttgc tttgggggta gaggcttctt 5220
agattctccc agcatccgcc tttcccttta gccagtctgc tgtcctgaaa cccagaagtg 5280
atggagagaa accaacaaga gatctcgaac cctgtctaga aggaatgtat ttgttgctaa 5340
atttcgtagc actgtttaca gttttcctcc atgttattta tgaattttat attccgtgaa 5400
tgtatattgt cttgtaatgt tgcataatgt tcacttttta tagtgtgtcc tttattctaa 5460
acagtaaagt ggttttattt ctatcac 5487
<210> 17
<211> 4934
<212> DNA
<213> Homo sapiens
<400> 17
gcgagctgag ctgacagcgc ggagctggcg ctgtggagcg cagggagcct tgccggttcc 60
tccgaccggc gtctgcgagt acagcggcgg ctaacctgcc ccggcttcag gatttacaca 120
gacgtggggc gatgcttgtg accctgcagc tcctcaaacc agcctgtatt gagcggtttg 180
cagcctgatg ctcagccccc tccccacagg gcccctagaa gcctgtttct ccgtacagtc 240
caggacctcc agccccatgg agcccccgat cccacagagc gcccccttga ctcccaactc 300
agtcatggtc cagccccttc ttgacagccg gatgtcccac agccggctcc agcacccact 360
caccatccta cccattgacc aggtgaagac cagccatgtg gagaatgact acatagacaa 420
ccctagcctg gccctgacca ccggcccaaa gcggacccgg ggcggggccc cagagctggc 480
cccgacgccc gcccgctgtg accaggatgt cacccaccat tggatctcct tcagcgggcg 540
ccccagctct gtgagcagca gcagcagcac atcctctgac caacggctct tagaccacat 600
ggcaccacca cccgtggctg accaggcctc accaagggct gtgcgcatcc agcccaaggt 660
ggtccactgc cagccgctgg acctcaaggg cccggcggtc ccacccgagc tggacaagca 720
cttcttgctg tgcgaggcct gtgggaagtg taaatgcaag gagtgtgcat ccccccggac 780
gttgccttcc tgctgggtct gcaaccagga gtgcctgtgc tcagcccaga ctctggtcaa 840
ctatggcacg tgcatgtgtt tggtgcaggg catcttctac cactgcacga atgaggacga 900
tgagggctcc tgcgctgacc acccctgctc ctgctcccgc tccaactgct gcgcccgctg 960
gtccttcatg ggtgctctct ccgtggtgct gccctgcctg ctctgctacc tgcctgccac 1020
cggctgcgtg aagctggccc agcgtggcta cgaccgtctg cgccgccctg gttgccgctg 1080
caagcacacg aacagcgtca tctgcaaagc agccagcggg gatgccaaga ccagcaggcc 1140
cgacaagcct ttctgacagt ttgtgtcgaa gccccagtgc tctgcctgga aacctggttc 1200
tcttctgaca tctaagaaga ctgcagcaag gtcagaggtt ttagcctcct gaggctgacc 1260
ttgctagtct gcccactccc tacccccagc ttcggaaaat acagagacca ccaccacgta 1320
ccctgtattc cccaaggtga tgaagaagca ctttggggct ttttttcagg gtcctgaaac 1380
tttgtgtcaa acagacaatg caggggcagg gtgtggtttg gggggaaatt tttctttttc 1440
agaagacaga acacagatgt ggacacatat ccggaaactg cagctgcttg aatgccttcc 1500
cagcccctcc ttctccctcc ctccctccgc cccccccttc ctcttttcca ttgtctttgg 1560
ctctcacagg agctagctgc ctgggaggaa ttgttaactg agtaccaggg tacctttaaa 1620
gaagaccctt ggagtcttct ataccttctt ctccttcccc atctcactcc accccacttt 1680
gtccctgatg tcttggggaa ggtgtagaac accctagcag ttcctattgt atatacttgg 1740
gagccactga gaacagagga cggccagtga gtccaagcct cgttcctcct tctgcctccc 1800
cggagccaca ggatggattt aggagccact gctcagtgca cttctccctt ccaactgcat 1860
caactaactc tcgggggtgt tctgctcacc acaccgtcct tcggttctta ctgagtcaca 1920
gactcgcctg cccactacgt gtcctgggtt ctctactcag atcccttcca gaaactttat 1980
atgggtagag gaagccaggg cggcaaatgc gagaccaaat atcattttgc caatgagtct 2040
gaggctgtgg tctctggatc cagtcattat gtttttatag aataattaaa ccggatgcta 2100
acggtgtttt aaaaaataat aataaaacaa cttgtttcct tttggccacc cccaggaagg 2160
gctgatttca aaatctgggg gcgagcaacc tcaaggaaca caatttccct ccctatcaac 2220
aagaggattt taacagcaaa gaagagaggc agcacctccc attggcagaa tgaccgctga 2280
gccaggctgg gtttgggttt cttctcttct gattctgctg ctcactgtca tagccttttg 2340
tgtatagtga tgtgtctgta tctttaatgt aaatagagag atgatgaaaa aagagtctat 2400
tttagtgtta ggaagcccca gcaggggagt cggaagagct tggaagagct ggggagaggg 2460
taggggaaag gtttttccag gggccactgg gtttgagccc tgcttctgtg cacagccaca 2520
ccaccctctc ccgacagccc tcaaagacgt agcaactctt tctctcaagg tgctaaagga 2580
ctcagaaggt gcagcacgtc cagtgggtag gtacttgttg catgcaaaag ctgtagtgta 2640
tctggtcctt cctccccagc ttttgtgtgg ggttcttgct ttgtgtggta ttttgttttc 2700
ccctctaatg agagggcatg gcctgagtca gaagagctac cccaggtgaa actggaagtg 2760
catgaggcag agcgtccgta gcatttccag tttgttctgt ataggacaga ggtgcctccg 2820
ggaaggaggc agcgaggtag gtagctatga taggcaccta atgcttctca aggacttatt 2880
ttttccttct tgaagactag tagtaacatc ttatgattta gagtaagttg attgtaacca 2940
taggtattta ttgattggag gaagggaggg tcatattatt ttcggcttta tttatgtaac 3000
atttgctagc ttataaaagg cgaatgtgaa atattgcatc tgcattttcc aaggctgatt 3060
cgtgtagcta cccttgccac agttgtgacg gatgtatgga tgttcttgaa catttcagaa 3120
ggagtggtag aaaaaaacac acattcagcc aaccacttat atgaattgaa tgtatcagaa 3180
gtgtactgaa gggactggag atggttttcc tcagatgagg gggccccaaa attgatagtg 3240
cacatctgca cgctttctgc gaggcctcag aacttttccc agggcccctc cctcaaattg 3300
tctccatggg aaacttgacc cagtggcaag ttgcactttg gtgatcttgg tggtctacac 3360
acccgttctg tggagagtcg atttacataa gctgtgtata cacacacaca cacacacaca 3420
cacacacaca cacacacacc cctaccccac actgactgtc taccgacaga gaccctattt 3480
cctggcaaac ggcctcctga accctgactt tttgtgtaca tacttgtaaa cacggatttt 3540
tctgggtttt ggtttgcttt ttcctttttt ccccctgccc ctgttctagc ttgttcttct 3600
tggtttgctt tcaacctgct tgatggatgt ctgcagagtg ctctctaaga gtccacctca 3660
gtgcctcgtg tgctcagtgg tcatgggaag gagcgaagga accatccttg gttctcccag 3720
cttggttgtg tagcaatccc tcagcattgt ttttctcagc ttcttggcaa aaattaaaac 3780
aacaacaaca acaacaacaa caacaacaaa cagaaggata aactggcttg cctgtggacc 3840
ctccccggct ctggggccag tcgagagcca ctgagggacc cagcactcag agacacaaca 3900
cacatgtgta gctgcttctg gctgagtgtg tttcctgtca ccaatggcct gtttggctgg 3960
acgatgcctc ggcttgacct tttttgaaaa gtgctggtta gttcccgccc cctggtaaac 4020
ctggggtagg tgggggttct gtcttaactc gaggggcacc tgggatccag gacgcttcta 4080
gggggctctg gctgcccgtg ttaatgaagg acagcgcttc cgcgagcacc ctgggaactg 4140
ggtcttgggt agcaaagccc tcccagagaa aagatgggca caactaaggc tttcctgagc 4200
aggaaggggg tgaagaccaa tcccttcctt tggtcctttg gtacgcaccc cctcagagct 4260
gagatggaag acatggctag ttcttttcag ccttgtggag cctgtcagtc gccatcatac 4320
ctcgagtgag gcccagctag ataatgactt gtccaagatg gcacacgtgg aaagttgatc 4380
tgcaccagaa cccggatgac tgtcaccttg aagcgtcctg ttctccttct gtgctgtccc 4440
aggaagtgtc tggcgggcgt gggcagcaca gctctacact gtacgattca ctagggcatc 4500
ctgcgagcct cactagcctt ctggttcatg cctttgacaa gcatttttgt gccccctctg 4560
cttactgtga cagtcgatga tgaatcttgc gttgccattt tctgctgtgg gtaactgcgt 4620
gcagtgtctt gccttgcttt ctcttcttac tgtcccacag cttggtttca tgttacaaac 4680
agaaaagctc gaggctccca ccccgccaca tcccaacttc atttccccct cactgtagcc 4740
catttccacc ccaccacaaa gttgccacag gttttctttg tatagaatat ttattttgaa 4800
gctctatttt aatagtattt attttagaaa gtctactatt gtaagagttc ttctgtttgt 4860
gaagaaaaaa acaagttaaa aactgaatgt actgatttag aaaatatata taaatatata 4920
ttgttaaata taaa 4934
<210> 18
<211> 2038
<212> DNA
<213> Homo sapiens
<400> 18
atggagagct accacaagcc tgaccagcag aagctgcagg ccttgaagga cacggccaac 60
cgcctacgta tcagctccat ccaggccacc actgcggcgg gctctggcca ccccacgtca 120
tgctgcagcg ccgcagagat catggctgtc ctctttttcc acaccatgcg ctacaagtcc 180
caggaccccc ggaatccgca caatgaccgc tttgtgctct ccaagggcca tgcagctccc 240
atcctctacg cggtctgggc tgaagctggt ttcctggccg aggcggagct gctgaacctg 300
aggaagatca gctccgactt ggacgggcac ccggtcccga aacaagcttt caccgacgtg 360
gccactggct ccctgggcca gggcctcggg gccgcttgtg ggatggccta caccggcaaa 420
tacttcgaca aggccagcta ccgagtctat tgcttgctgg gagacgggga gctgtcagag 480
ggctctgtat gggaggccat ggccttcgcc agcatctata agctggacaa cctcgtggcc 540
attctagaca tcaatcgcct gggccagagt gacccggccc ctctgcagca ccagatggac 600
atctaccaga agcggtgcga ggccttcggt tggcatgcca tcatcgtgga tggacacagc 660
gtggaggagc tgtgcaaggc ctttggccag gccaagcacc agccaacagc catcattgcc 720
aagaccttca agggccgagg gatcacgggg gtagaagata aggagtcttg gcatgggaag 780
cccctcccca aaaacatggc tgagcagatc atccaggaga tctacagcca gatccagagc 840
aaaaagaaga tcctggcaac ccctccacag gaggacgcac cctcagtgga cattgccaac 900
atccgcatgc ccagcctgcc cagctacaaa gttggggaca agatagccac ccgcaaggcc 960
tacgggcagg cactggccaa gctgggccat gccagtgacc gcatcatcgc cctggatggg 1020
gacaccaaaa attccacctt ctcggagatc ttcaaaaagg agcacccgga ccgcttcatc 1080
gagtgctaca ttgctgagca gaacatggtg agcatcgcgg tgggctgtgc cacccgcaac 1140
aggacggtgc ccttctgcag cacttttgca gccttcttca cgcgggcctt tgaccagatt 1200
cgcatggccg ccatctccga gagcaacatt aacctctgcg gctcccactg cggcgtttcc 1260
atcggggaag acgggccctc ccagatggcc ctagaagatc tggctatgtt tcggtcagtc 1320
cccacatcaa ctgtctttta cccaagtgat ggcgttgcta cagagaaggc agtggaacta 1380
gccgccaata caaagggtat ctgcttcatc cggaccagcc gcccagaaaa tgccatcatc 1440
tataacaaca atgaggactt ccaggtcgga caagccaagg tggtcctgaa gagcaaggat 1500
gaccaggtga ccgttatcgg ggctggggtg accctgcacg aggccttggc cgctgccgaa 1560
ctgctgaaga aagaaaagat caacatccgc gtgctggacc ccttcaccat caagcccctg 1620
gacagaaaac tcattctcga cagcgctcgt gccaccaagg gcaggatcct caccgtggag 1680
gaccattatt atgaaggtgg cattggtgag gctgtgtcca gtgcagtagt gggcgagcct 1740
ggcatcactg tcacccacct ggcagttaac cgggtaccaa gaagtgggaa gccggctgag 1800
ctgctgaaga tgtttggtat cgacagggat gccattgcac aagctgtgag gggcctcatc 1860
accaaggcct agggcgggta tgaagtgtgg ggcgggggtc tatacattcc tgagattctg 1920
ggaaaggtgc tcaaagatgt actgagagga ggggtaaata tatgttttga gaaaaatgaa 1980
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2038
<210> 19
<211> 946
<212> DNA
<213> Homo sapiens
<400> 19
ggaaacccaa gaggaaatga ctgagcccgt ctgggtcccc gcccgctcgc gctcccctgg 60
ccacaccctc cgcctggacg cagcagccac cgccgcgtcc ctctctccac gaggctgccg 120
gcttaggacc cccagctccg acatgtcgcc ctctggtcgc ctgtgtcttc tcaccatcgt 180
tggcctgatt ctccccacca gaggacagac gttgaaagat accacgtcca gttcttcagc 240
agactcaact atcatggaca ttcaggtccc gacacgagcc ccagatgcag tctacacaga 300
actccagccc acctctccaa ccccaacctg gcctgctgat gaaacaccac aaccccagac 360
ccagacccag caactggaag gaacggatgg gcctctagtg acagatccag agacacacaa 420
gagcaccaaa gcagctcatc ccactgatga caccacgacg ctctctgaga gaccatcccc 480
aagcacagac gtccagacag acccccagac cctcaagcca tctggttttc atgaggatga 540
ccccttcttc tatgatgaac acaccctccg gaaacggggg ctgttggtcg cagctgtgct 600
gttcatcaca ggcatcatca tcctcaccag tggcaagtgc aggcagctgt cccggttatg 660
ccggaatcgt tgcaggtgag tccatcagaa acaggagctg acaacctgct gggcacccga 720
agaccaagcc ccctgccagc tcaccgtgcc cagcctcctg catcccctcg aagagcctgg 780
ccagagaggg aagacacaga tgatgaagct ggagccaggg ctgccggtcc gagtctccta 840
cctcccccaa ccctgcccgc ccctgaaggc tacctggcgc cttgggggct gtccctcaag 900
ttatctcctc tgctaagaca aaaagtaaag cactgtggtc tttgcc 946
<210> 20
<211> 1246
<212> DNA
<213> Homo sapiens
<400> 20
gaccagccta cagccgcctg catctgtatc cagcgccagg tcccgccagt cccagctgcg 60
cgcgcccccc agtcccgcac ccgttcggcc caggctaagt tagccctcac catgccggtc 120
aaaggaggca ccaagtgcat caaatacctg ctgttcggat ttaacttcat cttctggctt 180
gccgggattg ctgtccttgc cattggacta tggctccgat tcgactctca gaccaagagc 240
atcttcgagc aagaaactaa taataataat tccagcttct acacaggagt ctatattctg 300
atcggagccg gcgccctcat gatgctggtg ggcttcctgg gctgctgcgg ggctgtgcag 360
gagtcccagt gcatgctggg actgttcttc ggcttcctct tggtgatatt cgccattgaa 420
atagctgcgg ccatctgggg atattcccac aaggatgagg tgattaagga agtccaggag 480
ttttacaagg acacctacaa caagctgaaa accaaggatg agccccagcg ggaaacgctg 540
aaagccatcc actatgcgtt gaactgctgt ggtttggctg ggggcgtgga acagtttatc 600
tcagacatct gccccaagaa ggacgtactc gaaaccttca ccgtgaagtc ctgtcctgat 660
gccatcaaag aggtcttcga caataaattc cacatcatcg gcgcagtggg catcggcatt 720
gccgtggtca tgatatttgg catgatcttc agtatgatct tgtgctgtgc tatccgcagg 780
aaccgcgaga tggtctagag tcagcttaca tccctgagca ggaaagttta cccatgaaga 840
ttggtgggat tttttgtttg tttgttttgt tttgtttgtt gtttgttgtt tgtttttttg 900
ccactaattt tagtattcat tctgcattgc tagataaaag ctgaagttac tttatgtttg 960
tcttttaatg cttcattcaa tattgacatt tgtagttgag cggggggttt ggtttgcttt 1020
ggtttatatt ttttcagttg tttgtttttg cttgttatat taagcagaaa tcctgcaatg 1080
aaaggtacta tatttgctag actctagaca agatattgta cataaaagaa tttttttgtc 1140
tttaaataga tacaaatgtc tatcaacttt aatcaagttg taacttatat tgaagacaat 1200
ttgatacata ataaaaaatt atgacaatgt caaaaaaaaa aaaaaa 1246
<210> 21
<211> 829
<212> DNA
<213> Homo sapiens
<400> 21
tggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct agcgactgaa 60
gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa caggtggagg 120
tcttcagaca gaatcttttc caggaggctg aggaattcct ctacagattc ttgccacaga 180
aaatcatata cctgaatcag ctcttgcaag aggactccct caatgtggct gacttgactt 240
ccctccgggc cccactggac atccccatcc cagaccctcc acccaaggat gatgagatgg 300
aaacagataa gcaggagaag aaagaagtcc ataagtgtgg atttctccct gggaatgaga 360
aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa gagaaatgca 420
ttctggtgat tacatggatc caacacctga tccccaagat tgaagatgga aatgattttg 480
gggtagcaat ccaggagaag gtgctggaga gggtgaatgc cgtcaagacc aaagtggaag 540
ctttccagac aaccatttcc aagtacttct cagaacgtgg ggatgctgtg gccaaggcct 600
ccaaggagac tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct 660
atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag ctttatcata 720
tcatcagcag caacctggag aaaattgtca acccaaaggg tgaagaaaag ccatctatgt 780
actgaacccg ggactagaag gaaaataaat gatctatatg ttgtgtgga 829
<210> 22
<211> 3224
<212> DNA
<213> Homo sapiens
<400> 22
agcggtaaat ttgaaatggc tgacgggtcg ctgacgggcg gcggtctgga ggcagcggcc 60
atggcgccgg agcgcacggg ctgggcggtg gagcaggagc tggcgtctct ggagaaaggt 120
ttgttccaag atgaagattc atgcagtgat tgtagctacc gtgataaacc aggttctagt 180
ttacaaagtt ttatgccaga aggaaaaacc tttttcccag aaattttcca aacaaatcaa 240
cttttgttct atgagcgatt cagagcctat caagattaca ttttagctga ctgcaaggcc 300
tctgaggtac aggaattcac agctgagttc ttggagaagg tccttgagcc atctggatgg 360
cgggcagtct ggcacactaa tgtgttcaag gtgctggttg agatcacaga tgtggacttt 420
gcagccttga aggcagtggt gaggcttgct gaaccatacc tctgtgactc tcaagtgagc 480
acttttacca tggagtgcat gaaggagctc cttgatctga aggagcatcg gttgcccctg 540
caggagctgt gggtggtgtt tgatgattca ggagtgtttg accagacagc ccttgcaatt 600
gagcatgtca gatttttcta ccaaaacatt tggaggagtt gggatgaaga agaggaggat 660
gaatacgatt attttgtcag atgtgttgaa cctcgattaa gattgcatta tgacattctt 720
gaagaccgag ttccatcagg acttattgtt gactaccaca atctgttgtc tcaatgtgag 780
gagagttaca ggaaattttt aaatctgaga agcagtttgt caaattgtaa ctctgattcc 840
gagcaggaaa atatctccat ggtggaaggg ttaaaattgt attcggagat ggaacagttg 900
aaacaaaagc tgaaactcat tgagaatcct ttgttgaggt atgtgtttgg ttatcagaag 960
aattctaaca tccaagcaaa gggtgtccgt tccagcggtc agaagatcac tcatgtggtc 1020
tcctccacca tgatggctgg tctcctgcgg tccctgctta cggacaggct ttgccaggag 1080
cctggtgagg aagaaagaga aattcagttc catagtgatc cattgtctgc tataaatgcc 1140
tgcttcgaag gtgacactgt tattgtttgt cctggccatt atgtggtaca tggcactttc 1200
tccattgctg actccattga gttggaagga tatggcctac cagatgacat tgtgatagaa 1260
aagaggggca aaggcgacac ttttgtggac tgcactggtg ctgatattaa aatctcaggc 1320
ataaaatttg ttcagcatga tgctgtagag ggaatcttaa ttgttcaccg tggtaagact 1380
acgctggaaa actgtgtgct gcagtgtgag acgaccggag tcacagtgcg gacatcagca 1440
gagtttctaa tgaagaactc ggatttatat ggcgccaagg gtgctggtat agaaatctac 1500
cctgggagtc agtgcaccct gagtgacaat gggatccatc actgcaagga agggatcctc 1560
attaaggact tcttagatga acattatgac attcccaaga tatccatggt gaataatata 1620
atacataata atgaaggtta tggtgttgtc ttggtgaaac ctacaatctt ctctgacctg 1680
caagaaagtg ctgaagatgg aactgaagaa aataaagcgc ttaaaattca gacaagtgga 1740
gagccagatg tggctgaaag agtggatcta gaagagctga ttgagtgtgc aactggtaaa 1800
atggagcttt gtgcaagaac tgacccttct gagcaagtcg agggaaattg tgaaattgta 1860
aatgaactaa ttgctgcctc cacacagaaa ggccagataa agaagaaaag gttgagtgaa 1920
ctggggatca cgcaagctga tgacaactta atgtcacagg agatgtttgt tgggattgtg 1980
gggaaccagt tcaagtggaa tgggaaaggt agttttggca catttctttt ctgactacag 2040
tgatgtaagt agatagcaaa atactggatt ttgcacatgc tgccctaaga atcactgctg 2100
ccattgtagt ttgctgtatt gtctgtattt tatatttgat tatttgggct tgagtgaaag 2160
gtagatttat ttccatttgc aggtgttgca cataaaacac tccctcttta taagaaaaat 2220
cataaatgca tataaaatag aaaatatttg gagattgctt atctgaaagt cttgctttct 2280
tatacacatg gttctctcat attaagcctg gtggtaactt tttagtgtaa ttacctttag 2340
cacttcaaag acgaggaagt aaggaaggga atgcaagact agtgcataaa aatgcaatag 2400
gtgtcatatg tacagcattc ttcttagagt tgccttttca tcccaattac agtgagtctg 2460
atttccatcc tgtatttgca taatacttgt cttaaaataa aagcttttat gattgggaat 2520
ttatctgcct aatcagactt attattgaga cgtcaatggg acgcattttt ctgttgagct 2580
atgcagtcgt caaaacagcg atagacagca taggaggttt gaagcagaaa tgaaatgtgt 2640
tattcagagc caatgttgta catagagcat tttcactatt gctgaatggg aatgattaaa 2700
aacaaggtat ttttcgggcc aggcggtggc tcacgcttgt aatcgcagca ctttgggagg 2760
ctgaggcagg aggatcactt gagcccagga gttcaagact agcctaggca acatagtgag 2820
accctgtctc tactaaaaat aaatttaaaa aaaattagct gagtgtggtg gtgcatgcat 2880
gtagttccag ctactcagga ggctgaggct agaggatcct tgagcccagg aggttgaggc 2940
tgcagtgagg tgtgattgcg ccactgcatt ccagcttggg cgacagagcg agacccagtc 3000
tcaaaaaaaa aaaaagtatt tttctcttac cgttacagta ttctgattat attactgaca 3060
cagtcaaaat gattaactgt acaacctgta tctgctgggt gttcttgtta tcatattgta 3120
aaacagcttt aaaaatattt atattttaaa aactgtatgt gacattaata tgcctaatga 3180
ttaaaattat agtgatgaaa taacaaagaa aaaaaaaaaa aaaa 3224
<210> 23
<211> 5145
<212> DNA
<213> Homo sapiens
<400> 23
cgggcccctc gccactaccg ccgccgccgc cgccgtgagt cccgcggagc cgcgcgcgcc 60
cccggctggg ccgagccgct ggccgacgag cggagcctca ggagccggcg gggacgccat 120
gcgagccagc gtctcccttc tctcctggac agaaggccgt gtcctgggac ttctctgatg 180
gcgagaggct gcggctgtac caggaagaaa catattgccg agtggatgcc gccgcgcagc 240
gtgtttgctt gaggcagaag cttcagcatc tgctgggata actggaggaa gaaatatgaa 300
gccttagcgg ctttacccgg gaagcgagtt tcgagatggc ggctcagcgg atccgagcgg 360
ccaactccaa tggcctccct cgctgcaagt cagaggggac cctgattgac ctgagcgaag 420
ggttttcaga gacgagcttt aatgacatca aagtgccttc tcccagtgcc ttgctcgtag 480
acaaccccac acctttcgga aatgcaaagg aagtgattgc gatcaaggac tattgcccca 540
ccaacttcac cacactgaag ttctccaagg gcgaccatct ctacgtcttg gacacatctg 600
gcggtgagtg gtggtacgca cacaacacca ccgaaatggg ctacatcccc tcctcctatg 660
tgcagccctt gaactaccgg aactcaacac tgagtgacag cggtatgatt gataatcttc 720
cagacagccc agacgaggta gccaaggagc tggagctgct cgggggatgg acagatgaca 780
aaaaagtacc aggcagaatg tacagtaata accctttctg gaatggggtc cagaccaatc 840
catttctgaa tgggaacgtg cccgtcatgc ccagcctgga tgagctgaat cccaaaagta 900
ctgtggattt gctccttttt gacgcaggta catcctcctt caccgaatcc agctcagcca 960
ccacgaatag cactggcaac atcttcgatg agcttccagt cacaaacgga ctccacgcag 1020
agccgccggt caggcgggac aaccccttct tcagaagcaa gcgctcctac agtctctcgg 1080
aactctccgt cctccaagcc aagtccgatg ctcccacatc gtcgagtttc ttcaccggct 1140
tgaaatcacc tgcccccgag caatttcaga gccgggagga ttttcgaact gcctggctaa 1200
accacaggaa gctggcccgg tcttgccacg acctggactt gcttggccaa agccctggtt 1260
ggggccagac ccaagccgtg gagacaaaca tcgtgtgcaa gctggatagc tccgggggtg 1320
ctgtccagct tcctgacacc agcatcagca tccacgtgcc cgagggccac gtcgcccctg 1380
gggagaccca gcagatctcc atgaaagccc tgctggaccc cccgctggag ctcaacagtg 1440
acaggtcctg cagcatcagc cctgtgctgg aggtcaagct gagcaacctg gaggtgaaaa 1500
cctctatcat cttggagatg aaagtgtcag ccgagataaa aaatgacctt tttagcaaaa 1560
gcacagtggg cctccagtgc ctgaggagcg actcgaagga agggccatat gtctccgtcc 1620
cgctcaactg cagctgtggg gacacggtcc aggcacagct gcacaacctg gagccctgta 1680
tgtacgtggc tgtcgtggcc catggcccaa gcatcctcta cccttccacc gtgtgggact 1740
tcatcaataa aaaagtcaca gtgggtctct acggccctaa acacatccac ccatccttca 1800
agacggtagt gaccattttt gggcatgact gtgccccaaa gacgctcctg gtcagcgagg 1860
tcacacgcca ggcacccaac cctgccccgg tggccctgca gctgtggggg aagcaccagt 1920
tcgttttgtc caggccccag gatctcaagg tctgtatgtt ttccaatatg acgaattacg 1980
aggtcaaagc cagcgagcag gccaaagtgg tgcgaggatt ccagctgaag ctgggcaagg 2040
tgagccgcct gatcttcccc atcacctccc agaaccccaa cgagctctct gacttcacgc 2100
tgcgggttca ggtgaaggac gaccaggagg ccatcctcac ccagttttgt gtccagactc 2160
ctcagccacc ccctaaaagt gccatcaagc cttccgggca aaggaggttt ctcaagaaga 2220
acgaagtcgg gaaaatcatc ctgtccccgt ttgccaccac tacaaagtac ccgactttcc 2280
aggaccgccc ggtgtccagc ctcaagtttg gtaagttgct caagactgtg gtgcggcaga 2340
acaagaacca ctacctgctg gagtacaaga agggcgacgg gatcgccctg ctcagcgagg 2400
agcgggtcag gctccggggc cagctgtgga ccaaggagtg gtacatcggc tactaccagg 2460
gcagggtggg cctcgtgcac accaagaacg tgctggtggt cggcagggcc cggcccagcc 2520
tgtgctcggg ccccgagctg agcacctcgg tgctgctgga gcagatcctg cggccctgca 2580
aattcctcac gtacatctat gcctccgtga ggaccctgct catggagaac atcagcagct 2640
ggcgctcctt cgctgacgcc ctgggctacg tgaacctgcc gctcaccttt ttctgccggg 2700
cagagctgga tagtgagccc gagcgggtgg cgtccgtcct agaaaagctg aaggaggact 2760
gtaacaacac tgagaacaaa gaacggaagt ccttccagaa ggagcttgtg atggccctac 2820
tgaagatgga ctgccagggc ctggtggtca gactcatcca ggactttgtg ctcctgacca 2880
cggctgtaga ggtggcccag cgctggcggg agctggctga gaagctggcc aaggtctcca 2940
agcagcagat ggacgcctac gagtctcccc accgggacag gaacggggtt gtggacagcg 3000
aggccatgtg gaagcctgcg tatgacttct tactcacctg gagccatcag atcggggaca 3060
gctaccggga tgtcatccag gagctgcacc tgggcctgga caagatgaaa aaccccatca 3120
ccaagcgctg gaagcacctc actgggactc tgatcttggt gaactccctg gacgttctga 3180
gagcagccgc cttcagccct gcggaccagg acgacttcgt gatttgaatg ggtcccctcc 3240
cctcctgctg ctctggagtg caagccctct tctgccctgc gtgccctgct gtcaccgcgg 3300
agctgaagag ggaggaaggg gcggctgctc agacagattt agggcccgcc agctaggcta 3360
cacccatcat gcgccgccct cctccatcga gggagaggcc tgaagggact gcctactgca 3420
gctcgttgcc aatcacatag ctttctattt gttaagtata aatttaaatt taaaatcact 3480
tttttaacga atggggggaa gggatctatg agaaaggtgg tatctaattt ttttatggac 3540
cataaaggtt taaaagaaaa taggggcaca ggctgttgag gtttttatgt tgttatagac 3600
ctttttaaat tatgttagag atgtatatag gtatttaaag gtcactggga gcgtttctga 3660
ttcccggcca cactttgcat ttcaacactc agcccggaaa gatgctcgtt cggttgttgg 3720
acctctttca ctccctgcgt gtaagaaggt gaatcacgtg ggaaaaagtg gcttttcagt 3780
aaacgggtac agctcattct ttctgagaag gccccaggtc ctgctccctc ctcggatttg 3840
attgtcttcc gtgctttgcc tcactcgtag taaatgacca tccatagaat atgtgaatct 3900
ttggtgagct tcagtgggca gagtgaagtc ccgcattagc atttaggtgc cctgagctgt 3960
ttctgccaat agattagaaa gcagccatga gttgacagtc tttagggccc ctgccagtgt 4020
gcaattagtc attgacaaga acaatgccat ttgagagtga ggtggtccct gctgctacga 4080
ggccattgta ctgttttttc cttgaggtca aagcagtgct tcccatagag tttgctgcct 4140
cttctgtgga caggaagaaa acttcatgac cgaatcagag ccttggtggc cactgactct 4200
cgtgcttatt gcagatgctg tggttggcct cacaagcaac gccttatgct gatgtgcaga 4260
ggtgccagct gccatttgcc aaactctgca tttcatttca tctaaggctt aacccctctt 4320
ccttcctggt gtacctgtgt ctcctcggaa ggaagtcata gtttagatga aaccattttt 4380
tgtacaatgt aaagatcatc tgagcaagat gagcattttg taaaaatgaa aatgtgactc 4440
acataaaatc aggaacttga cacagtgttg cattaataac tttagggtgc agacatgctg 4500
tgtgaatctc acaatgcgtc gtagatgtcg cgtgttggaa gggagcagga ggaaggactg 4560
atactggcaa atcagtagag tgaggtgatc cttagcaacg tgccaggaca cttcctgtgt 4620
gcctgcagtt gtcagggacc atttgggatc ccgaatctca ttctctaaaa ctgctttctt 4680
gaaacatgtt acttccttag tataatcaat gtatactccc ttactggcct gaaacgttgt 4740
atagctactt attcagatac tgaagaccaa cggactgaaa aaaagaacaa acattagcta 4800
ttttatgctg caagaaccag gacacacaat tcgccaatca tcccaccata taaccttcga 4860
ttgtgcttct caactccacc ccataatttc tcccagagac catctatcac cttttcccca 4920
aagaagaaac aaaaccagtt gcaccttaaa ccatggatat tttttcctca ggggctttaa 4980
atagtttcct atgcaacgtg tcttgtagca caaataaaat tctacaaaag ttgcagtaaa 5040
ttttatttgg atattttaac ctgttaagtg tgtgtgtgtt ttctgtaccc aaccagactt 5100
taaataaaac aaacatgaaa cctaaaaaaa aaaaaaaaaa aaaaa 5145
<210> 24
<211> 2749
<212> DNA
<213> Homo sapiens
<400> 24
gcacaaacaa gctggagcag cccagaggac aagaattttg ggcagatttg aatgccatga 60
acgtgtatga aacaactgaa tttgaccaac tacgaaggct gtccacacca ccctctagca 120
atgtcaactc tatttaccac acagtctgga aattcttctg tagggaccac tttggatgga 180
gagagtatcc cgagtctgtc attcgattga ttgaagaagc caactctcgg ggtctgaaag 240
aggttcgatt tatgatgtgg aataaccact acatcctcca caattcattc ttcaggagag 300
agataaaaag gagacccctc ttccgctcct gttttatact gcttccatat ttacagacac 360
ttggtggggt tcccacacaa gctcctccac ctcttgaagc aacttcatca tcacaaatta 420
tctgcccaga tggggtcact tcagcaaact tttaccctga aacttgggtt tatatgcatc 480
catctcagga cttcatccaa gtccctgttt ctgcagagga taaaagttat cggatcattt 540
acaatctttt tcataagact gtgcctgagt ttaaatacag aattttgcag atattgagag 600
tccaaaacca gtttctttgg gagaaatata aaaggaaaaa ggaatatatg aacaggaaaa 660
tgtttggccg tgacaggata ataaatgaga gacatttatt tcatggaaca tcccaggatg 720
tggtagatgg aatctgcaaa cacaactttg accctcgagt ctgtggaaag catgctacaa 780
tgtttggaca aggcagttat tttgcaaaga aggcaagcta ctctcataac ttttctaaga 840
agtcctccaa aggagtccac ttcatgtttc tggccaaagt gctgacgggc agatacacaa 900
tgggcagtca tggcatgaga aggcccccgc cagtcaatcc tggcagtgtc accagtgacc 960
tttatgactc ttgtgtggat aatttctttg agcctcagat ttttgtcatt tttaatgatg 1020
accagagtta cccttatttt gttatccaat atgaagaagt cagtaacact gtttccattt 1080
gaaaaatctt ggtactgcta aattatttga tatgaactca atccagcatt tgtagcaggt 1140
tttgaatggg tgggactggg tggggaacag cattggacat taatagggca cttttcagac 1200
ccatttttta aagtgctaga aaatgctttt ttttaaaaaa aaatacaagt tttaaaatga 1260
ccacttactc tttaattatt tactaattgc tagtgtactc agtgtggaaa agactacaga 1320
ttacacactc ttttcattca cacttgtaca tatagacagc aatgttatta ggagcattaa 1380
attaaaaaac tgaacagcct aatttaaatg tggcttgggc ctggtagaag tttgaccaaa 1440
tggaatggag gctgtgagca atgtgaggat tctatttatt tatttacgtt tgataaaact 1500
tactggaact agtactacca tgcgtattcc ctgtccaaag catcactgct ttggtatagt 1560
ataagttcat gaaattctgg tgggtagaaa gaaattttta tttctatcag cagtactaaa 1620
atgtatcagc caaccagaga acatcagtga ctttaacttc tgcagagttt gccccagaat 1680
tcagagttct atttagagga agttaaaaca acaacaaaaa acaaccattt gaaaaatttt 1740
tgtcaccagc aaaacttttc actaattagt gatatgaaat gtgatttttg tgttgttaaa 1800
cttcagcttt ggaaaactca gtctctttca ttatcatcca ttccaatttg aaggagttgg 1860
gcagctaatt tggttaaagg cagtcttgag ggttagaagt attacttcct tttcgggttc 1920
cagacctagc ttgtgactga aagttttaga aaaaggaagt acatctatag ccgaattgat 1980
aaggttatta ctgtgttttg cacaaagtat attagcaaaa gtatttgctg gaattattgg 2040
tagatggcag tcccactcct acacctgctt tgtcagatac agctgggttc cctggctgac 2100
tctgtacctt acttacacta cttacttaat agaaacacaa acttggaaat tgtgccagtg 2160
gtccagctgg agcacaacgt ttggtgaata tgctgtttcc tcagttcaga gaggtagcaa 2220
ctaggtaaac tccttataaa aagcaaatac ctggatttac aaaagtgaaa gtagttgttc 2280
acaaaagaat tcgccatgga attctttcag ttaccaagct ctcctggtaa tgtttgtggt 2340
tatatcattt acacaaaact tttcaggaac ttctgtgttg tttaagcaag atgtatctgt 2400
actgatgtct cagtgaatca gtctgtttat taagcactta tcagggcttc cacacactta 2460
tttattttgc cctagttaat cctgttgttt gctgccattg gcatgaaatg gccaactgtg 2520
gctgttacag ttctttcatt caattataac ttgtaaacca gtgactccta atctttttca 2580
agttaagaca ccttaccatt gcttatttgg ttttatgaga cttgttcctt tttttctccc 2640
taaggaaaaa gaaagcttta tgacatattt atttttttaa taaaactaag caaaaataaa 2700
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2749
<210> 25
<211> 2358
<212> DNA
<213> Homo sapiens
<400> 25
gagtcctcag ctctccctac tccacgctgc ctagacatac acagctgcag ggtctggctg 60
aacaatcaag gggccgccag agaaaggcca tctacggtgc gcagtgtatc tggagttgct 120
gggcccaaga tagctctgtg gagttatcac tagagatgcc tctggattaa ctaagaggtg 180
tgcctgggtg tgggtgagga gtcagaacct ttgagagctt tgagatgaca gtttctatgg 240
ggcgggaaga aggaggtgca tttctacaaa cacttccctg aaatccttgg gaaaaacaga 300
ggcatggccg tggccaactc tgtgggaact ggcgcctctg tccttgttgg cactgttctc 360
agtccgatga cttgcattgt gttttctcca atttttgctg ggattttaat gttcagcatg 420
gtgggaggaa cccttgattc cttttgtttg agtatagaaa gtaaattttt gaggtcatga 480
tgtgaacggc catgttattg tgattatctt cagctcagga taggctgaga tgctttgtgg 540
agtgttccat gaagcccgag tcggaatctc tgactgtcgt gtacagccat aaggagactg 600
gtttgaatta ctgtggcgag acagggcgtg cctgtcagaa atctgagatg tttgtacgct 660
ctgagatgtt gaacctttct ggtgggcagc accgacaccc aggggtggac ccccgaggat 720
gaatgcctct aggcctccgc aacatattca agaatgaatg ggagacgcta gagtaaaatg 780
ggggcagaga ggatatcagg gagcaagatg caaactgtgt gcatccactc tcgtaaacaa 840
gtagctggtc acaaccagaa aggttcatct ctcctaagca aacagcgact ctttcagagg 900
aagtttccct ctttcaatcg tggccttatt ttcaactccg gtgccttctc gtgatgttaa 960
tcatttcctt ttttccccac actaagctct cttttctatc tttctctctc tttccaatct 1020
tacgccatgg ccatcagttc atttcagcct tccagtgcta cacccacttc ttggctgaca 1080
cacttctgct ctaaggtgac tggttttctt gccaattttc aaagagtggt actaaccccc 1140
aacccgcttt ccgcaccccg tcctctccgc cagcagtact ggttgcacta actgtgagtg 1200
tcttgcatac tgatggactc atttggtggc atggttggct aacagcatgg cggggggtgt 1260
tcagcttgag acccatgcct gtgttcattt cccatggagc tggcagcctg gtctacccca 1320
agtgcatgcc ccgcctctcc tctctccctt gggtctgcct gcgtgcatgc ttctccagtt 1380
gcgtctgcga agctacctac tttcttggga gggtcgacct tgatcatgaa acaataccat 1440
gagggggcct ctgtcacctt tgaaaagaac actttttgag cagcctcaaa aagctcatac 1500
ataccagcgc cttcttaaat tggctctaat gtaaagattg ttaatgtcat ttatcaaaac 1560
cataggtgat tatttggagg gatttaaaaa acttaattac tctcaggcct catcccaagc 1620
ttgacacatg ctctgtaggt tgaacacata atcacaaata ttctagcaaa tgctgccttg 1680
gttgcagcct gcactgtaga cccaagggtt ttgctgtggc tcttcttatc tcccttggct 1740
cataaagccc cagatgatgc cagagcttca attagagcca tcatcatccc aggcagggat 1800
atctttgaga aatgactcag ttcagcccca ggcccctgtg actctgctta aagcacacat 1860
ttctgctgac tcttgtacct ggggcagcag gataatcacc aacacactct taacgagaaa 1920
caacacacca agcacagtgg agctgtccta ggcaacactc gcggtctcag gctgcggtgg 1980
gcgtctgtcc tgcatgtggc ccagaccacc ctgacccccg ggcctgcctg cctggccctg 2040
catgctgcac gctcactgta tttgtgcaga tcctggccag tacaaagtcg ttgctcttgt 2100
cttatcttct cttacagagt ctccctccct ttatagaatg tcaaccaaag agtgccctcc 2160
tcccctctca gcctcctctt tagctagcct ccccatctca tcacaacgca tgtctgtgac 2220
ctttggtaat catttacagt gccacacgga accctgtatt ttgcacacag caaaacaaac 2280
aatgtttagc tttatttatg gtatttgatg ctgtaaatgg aaataaatat tgttctttat 2340
aaaaaaaaaa aaaaaaaa 2358
<210> 26
<211> 2944
<212> PRT
<213> Homo sapiens
<400> 26
Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala
1 5 10 15
Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr
20 25 30
Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser
35 40 45
Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu
50 55 60
Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala
65 70 75 80
Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala
85 90 95
Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr
100 105 110
Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp
115 120 125
His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys
130 135 140
Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala
145 150 155 160
Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys
165 170 175
Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser
180 185 190
Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu
195 200 205
Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val
210 215 220
Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu
225 230 235 240
Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser
245 250 255
Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu
260 265 270
Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly
275 280 285
Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln
290 295 300
Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser
305 310 315 320
Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln
325 330 335
Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly
340 345 350
Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr
355 360 365
Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp
370 375 380
Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly
385 390 395 400
Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser
405 410 415
Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu
420 425 430
Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp
435 440 445
Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser
450 455 460
Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr
465 470 475 480
Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro
485 490 495
Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr
500 505 510
Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp
515 520 525
Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr
530 535 540
Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe
545 550 555 560
Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser
565 570 575
Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg
580 585 590
Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val
595 600 605
Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala
610 615 620
Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser
625 630 635 640
Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln
645 650 655
Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu
660 665 670
Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro
675 680 685
Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile
690 695 700
Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His
705 710 715 720
Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr
725 730 735
Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His
740 745 750
Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val
755 760 765
Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile
770 775 780
Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr
785 790 795 800
Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro
805 810 815
Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg
820 825 830
Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val
835 840 845
Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro
850 855 860
Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu
865 870 875 880
His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe
885 890 895
Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu
900 905 910
Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr
915 920 925
Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro
930 935 940
Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile
945 950 955 960
Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp
965 970 975
Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu
980 985 990
Arg Gly Pro Gly Gln Glu Val Pro Gly Ser Pro Gln Thr Leu Pro Gly
995 1000 1005
Ile Ser Ser Ser Gln Arg Val Thr Gly Leu Glu Pro Gly Val Ser Tyr
1010 1015 1020
Ile Phe Ser Leu Thr Pro Val Leu Asp Gly Val Arg Gly Pro Glu Ala
1025 1030 1035 1040
Ser Val Thr Gln Thr Pro Val Cys Pro Arg Gly Leu Ala Asp Val Val
1045 1050 1055
Phe Leu Pro His Ala Thr Gln Asp Asn Ala His Arg Ala Glu Ala Thr
1060 1065 1070
Arg Arg Val Leu Glu Arg Leu Val Leu Ala Leu Gly Pro Leu Gly Pro
1075 1080 1085
Gln Ala Val Gln Val Gly Leu Leu Ser Tyr Ser His Arg Pro Ser Pro
1090 1095 1100
Leu Phe Pro Leu Asn Gly Ser His Asp Leu Gly Ile Ile Leu Gln Arg
1105 1110 1115 1120
Ile Arg Asp Met Pro Tyr Met Asp Pro Ser Gly Asn Asn Leu Gly Thr
1125 1130 1135
Ala Val Val Thr Ala His Arg Tyr Met Leu Ala Pro Asp Ala Pro Gly
1140 1145 1150
Arg Arg Gln His Val Pro Gly Val Met Val Leu Leu Val Asp Glu Pro
1155 1160 1165
Leu Arg Gly Asp Ile Phe Ser Pro Ile Arg Glu Ala Gln Ala Ser Gly
1170 1175 1180
Leu Asn Val Val Met Leu Gly Met Ala Gly Ala Asp Pro Glu Gln Leu
1185 1190 1195 1200
Arg Arg Leu Ala Pro Gly Met Asp Ser Val Gln Thr Phe Phe Ala Val
1205 1210 1215
Asp Asp Gly Pro Ser Leu Asp Gln Ala Val Ser Gly Leu Ala Thr Ala
1220 1225 1230
Leu Cys Gln Ala Ser Phe Thr Thr Gln Pro Arg Pro Glu Pro Cys Pro
1235 1240 1245
Val Tyr Cys Pro Lys Gly Gln Lys Gly Glu Pro Gly Glu Met Gly Leu
1250 1255 1260
Arg Gly Gln Val Gly Pro Pro Gly Asp Pro Gly Leu Pro Gly Arg Thr
1265 1270 1275 1280
Gly Ala Pro Gly Pro Gln Gly Pro Pro Gly Ser Ala Thr Ala Lys Gly
1285 1290 1295
Glu Arg Gly Phe Pro Gly Ala Asp Gly Arg Pro Gly Ser Pro Gly Arg
1300 1305 1310
Ala Gly Asn Pro Gly Thr Pro Gly Ala Pro Gly Leu Lys Gly Ser Pro
1315 1320 1325
Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Glu Arg Gly Pro Arg Gly
1330 1335 1340
Pro Lys Gly Glu Pro Gly Ala Pro Gly Gln Val Ile Gly Gly Glu Gly
1345 1350 1355 1360
Pro Gly Leu Pro Gly Arg Lys Gly Asp Pro Gly Pro Ser Gly Pro Pro
1365 1370 1375
Gly Pro Arg Gly Pro Leu Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly
1380 1385 1390
Leu Pro Gly Thr Ala Met Lys Gly Asp Lys Gly Asp Arg Gly Glu Arg
1395 1400 1405
Gly Pro Pro Gly Pro Gly Glu Gly Gly Ile Ala Pro Gly Glu Pro Gly
1410 1415 1420
Leu Pro Gly Leu Pro Gly Ser Pro Gly Pro Gln Gly Pro Val Gly Pro
1425 1430 1435 1440
Pro Gly Lys Lys Gly Glu Lys Gly Asp Ser Glu Asp Gly Ala Pro Gly
1445 1450 1455
Leu Pro Gly Gln Pro Gly Ser Pro Gly Glu Gln Gly Pro Arg Gly Pro
1460 1465 1470
Pro Gly Ala Ile Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Leu
1475 1480 1485
Gly Glu Ala Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Pro Ala Gly
1490 1495 1500
Ser Arg Gly Leu Pro Gly Val Ala Gly Arg Pro Gly Ala Lys Gly Pro
1505 1510 1515 1520
Glu Gly Pro Pro Gly Pro Thr Gly Arg Gln Gly Glu Lys Gly Glu Pro
1525 1530 1535
Gly Arg Pro Gly Asp Pro Ala Val Val Gly Pro Ala Val Ala Gly Pro
1540 1545 1550
Lys Gly Glu Lys Gly Asp Val Gly Pro Ala Gly Pro Arg Gly Ala Thr
1555 1560 1565
Gly Val Gln Gly Glu Arg Gly Pro Pro Gly Leu Val Leu Pro Gly Asp
1570 1575 1580
Pro Gly Pro Lys Gly Asp Pro Gly Asp Arg Gly Pro Ile Gly Leu Thr
1585 1590 1595 1600
Gly Arg Ala Gly Pro Pro Gly Asp Ser Gly Pro Pro Gly Glu Lys Gly
1605 1610 1615
Asp Pro Gly Arg Pro Gly Pro Pro Gly Pro Val Gly Pro Arg Gly Arg
1620 1625 1630
Asp Gly Glu Val Gly Glu Lys Gly Asp Glu Gly Pro Pro Gly Asp Pro
1635 1640 1645
Gly Leu Pro Gly Lys Ala Gly Glu Arg Gly Leu Arg Gly Ala Pro Gly
1650 1655 1660
Val Arg Gly Pro Val Gly Glu Lys Gly Asp Gln Gly Asp Pro Gly Glu
1665 1670 1675 1680
Asp Gly Arg Asn Gly Ser Pro Gly Ser Ser Gly Pro Lys Gly Asp Arg
1685 1690 1695
Gly Glu Pro Gly Pro Pro Gly Pro Pro Gly Arg Leu Val Asp Thr Gly
1700 1705 1710
Pro Gly Ala Arg Glu Lys Gly Glu Pro Gly Asp Arg Gly Gln Glu Gly
1715 1720 1725
Pro Arg Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly Ala Pro Gly Glu
1730 1735 1740
Arg Gly Ile Glu Gly Phe Arg Gly Pro Pro Gly Pro Gln Gly Asp Pro
1745 1750 1755 1760
Gly Val Arg Gly Pro Ala Gly Glu Lys Gly Asp Arg Gly Pro Pro Gly
1765 1770 1775
Leu Asp Gly Arg Ser Gly Leu Asp Gly Lys Pro Gly Ala Ala Gly Pro
1780 1785 1790
Ser Gly Pro Asn Gly Ala Ala Gly Lys Ala Gly Asp Pro Gly Arg Asp
1795 1800 1805
Gly Leu Pro Gly Leu Arg Gly Glu Gln Gly Leu Pro Gly Pro Ser Gly
1810 1815 1820
Pro Pro Gly Leu Pro Gly Lys Pro Gly Glu Asp Gly Lys Pro Gly Leu
1825 1830 1835 1840
Asn Gly Lys Asn Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Arg Lys
1845 1850 1855
Gly Glu Lys Gly Asp Ser Gly Ala Ser Gly Arg Glu Gly Arg Asp Gly
1860 1865 1870
Pro Lys Gly Glu Arg Gly Ala Pro Gly Ile Leu Gly Pro Gln Gly Pro
1875 1880 1885
Pro Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Gln Gly Phe Pro Gly
1890 1895 1900
Val Pro Gly Gly Thr Gly Pro Lys Gly Asp Arg Gly Glu Thr Gly Ser
1905 1910 1915 1920
Lys Gly Glu Gln Gly Leu Pro Gly Glu Arg Gly Leu Arg Gly Glu Pro
1925 1930 1935
Gly Ser Val Pro Asn Val Asp Arg Leu Leu Glu Thr Ala Gly Ile Lys
1940 1945 1950
Ala Ser Ala Leu Arg Glu Ile Val Glu Thr Trp Asp Glu Ser Ser Gly
1955 1960 1965
Ser Phe Leu Pro Val Pro Glu Arg Arg Arg Gly Pro Lys Gly Asp Ser
1970 1975 1980
Gly Glu Gln Gly Pro Pro Gly Lys Glu Gly Pro Ile Gly Phe Pro Gly
1985 1990 1995 2000
Glu Arg Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Pro Gln Gly Pro
2005 2010 2015
Pro Gly Leu Ala Leu Gly Glu Arg Gly Pro Pro Gly Pro Ser Gly Leu
2020 2025 2030
Ala Gly Glu Pro Gly Lys Pro Gly Ile Pro Gly Leu Pro Gly Arg Ala
2035 2040 2045
Gly Gly Val Gly Glu Ala Gly Arg Pro Gly Glu Arg Gly Glu Arg Gly
2050 2055 2060
Glu Lys Gly Glu Arg Gly Glu Gln Gly Arg Asp Gly Pro Pro Gly Leu
2065 2070 2075 2080
Pro Gly Thr Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Val Ser Val
2085 2090 2095
Asp Glu Pro Gly Pro Gly Leu Ser Gly Glu Gln Gly Pro Pro Gly Leu
2100 2105 2110
Lys Gly Ala Lys Gly Glu Pro Gly Ser Asn Gly Asp Gln Gly Pro Lys
2115 2120 2125
Gly Asp Arg Gly Val Pro Gly Ile Lys Gly Asp Arg Gly Glu Pro Gly
2130 2135 2140
Pro Arg Gly Gln Asp Gly Asn Pro Gly Leu Pro Gly Glu Arg Gly Met
2145 2150 2155 2160
Ala Gly Pro Glu Gly Lys Pro Gly Leu Gln Gly Pro Arg Gly Pro Pro
2165 2170 2175
Gly Pro Val Gly Gly His Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly
2180 2185 2190
Leu Ala Gly Pro Ala Gly Pro Gln Gly Pro Ser Gly Leu Lys Gly Glu
2195 2200 2205
Pro Gly Glu Thr Gly Pro Pro Gly Arg Gly Leu Thr Gly Pro Thr Gly
2210 2215 2220
Ala Val Gly Leu Pro Gly Pro Pro Gly Pro Ser Gly Leu Val Gly Pro
2225 2230 2235 2240
Gln Gly Ser Pro Gly Leu Pro Gly Gln Val Gly Glu Thr Gly Lys Pro
2245 2250 2255
Gly Ala Pro Gly Arg Asp Gly Ala Ser Gly Lys Asp Gly Asp Arg Gly
2260 2265 2270
Ser Pro Gly Val Pro Gly Ser Pro Gly Leu Pro Gly Pro Val Gly Pro
2275 2280 2285
Lys Gly Glu Pro Gly Pro Thr Gly Ala Pro Gly Gln Ala Val Val Gly
2290 2295 2300
Leu Pro Gly Ala Lys Gly Glu Lys Gly Ala Pro Gly Gly Leu Ala Gly
2305 2310 2315 2320
Asp Leu Val Gly Glu Pro Gly Ala Lys Gly Asp Arg Gly Leu Pro Gly
2325 2330 2335
Pro Arg Gly Glu Lys Gly Glu Ala Gly Arg Ala Gly Glu Pro Gly Asp
2340 2345 2350
Pro Gly Glu Asp Gly Gln Lys Gly Ala Pro Gly Pro Lys Gly Phe Lys
2355 2360 2365
Gly Asp Pro Gly Val Gly Val Pro Gly Ser Pro Gly Pro Pro Gly Pro
2370 2375 2380
Pro Gly Val Lys Gly Asp Leu Gly Leu Pro Gly Leu Pro Gly Ala Pro
2385 2390 2395 2400
Gly Val Val Gly Phe Pro Gly Gln Thr Gly Pro Arg Gly Glu Met Gly
2405 2410 2415
Gln Pro Gly Pro Ser Gly Glu Arg Gly Leu Ala Gly Pro Pro Gly Arg
2420 2425 2430
Glu Gly Ile Pro Gly Pro Leu Gly Pro Pro Gly Pro Pro Gly Ser Val
2435 2440 2445
Gly Pro Pro Gly Ala Ser Gly Leu Lys Gly Asp Lys Gly Asp Pro Gly
2450 2455 2460
Val Gly Leu Pro Gly Pro Arg Gly Glu Arg Gly Glu Pro Gly Ile Arg
2465 2470 2475 2480
Gly Glu Asp Gly Arg Pro Gly Gln Glu Gly Pro Arg Gly Leu Thr Gly
2485 2490 2495
Pro Pro Gly Ser Arg Gly Glu Arg Gly Glu Lys Gly Asp Val Gly Ser
2500 2505 2510
Ala Gly Leu Lys Gly Asp Lys Gly Asp Ser Ala Val Ile Leu Gly Pro
2515 2520 2525
Pro Gly Pro Arg Gly Ala Lys Gly Asp Met Gly Glu Arg Gly Pro Arg
2530 2535 2540
Gly Leu Asp Gly Asp Lys Gly Pro Arg Gly Asp Asn Gly Asp Pro Gly
2545 2550 2555 2560
Asp Lys Gly Ser Lys Gly Glu Pro Gly Asp Lys Gly Ser Ala Gly Leu
2565 2570 2575
Pro Gly Leu Arg Gly Leu Leu Gly Pro Gln Gly Gln Pro Gly Ala Ala
2580 2585 2590
Gly Ile Pro Gly Asp Pro Gly Ser Pro Gly Lys Asp Gly Val Pro Gly
2595 2600 2605
Ile Arg Gly Glu Lys Gly Asp Val Gly Phe Met Gly Pro Arg Gly Leu
2610 2615 2620
Lys Gly Glu Arg Gly Val Lys Gly Ala Cys Gly Leu Asp Gly Glu Lys
2625 2630 2635 2640
Gly Asp Lys Gly Glu Ala Gly Pro Pro Gly Arg Pro Gly Leu Ala Gly
2645 2650 2655
His Lys Gly Glu Met Gly Glu Pro Gly Val Pro Gly Gln Ser Gly Ala
2660 2665 2670
Pro Gly Lys Glu Gly Leu Ile Gly Pro Lys Gly Asp Arg Gly Phe Asp
2675 2680 2685
Gly Gln Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Glu Arg Gly
2690 2695 2700
Thr Pro Gly Ile Gly Gly Phe Pro Gly Pro Ser Gly Asn Asp Gly Ser
2705 2710 2715 2720
Ala Gly Pro Pro Gly Pro Pro Gly Ser Val Gly Pro Arg Gly Pro Glu
2725 2730 2735
Gly Leu Gln Gly Gln Lys Gly Glu Arg Gly Pro Pro Gly Glu Arg Val
2740 2745 2750
Val Gly Ala Pro Gly Val Pro Gly Ala Pro Gly Glu Arg Gly Glu Gln
2755 2760 2765
Gly Arg Pro Gly Pro Ala Gly Pro Arg Gly Glu Lys Gly Glu Ala Ala
2770 2775 2780
Leu Thr Glu Asp Asp Ile Arg Gly Phe Val Arg Gln Glu Met Ser Gln
2785 2790 2795 2800
His Cys Ala Cys Gln Gly Gln Phe Ile Ala Ser Gly Ser Arg Pro Leu
2805 2810 2815
Pro Ser Tyr Ala Ala Asp Thr Ala Gly Ser Gln Leu His Ala Val Pro
2820 2825 2830
Val Leu Arg Val Ser His Ala Glu Glu Glu Glu Arg Val Pro Pro Glu
2835 2840 2845
Asp Asp Glu Tyr Ser Glu Tyr Ser Glu Tyr Ser Val Glu Glu Tyr Gln
2850 2855 2860
Asp Pro Glu Ala Pro Trp Asp Ser Asp Asp Pro Cys Ser Leu Pro Leu
2865 2870 2875 2880
Asp Glu Gly Ser Cys Thr Ala Tyr Thr Leu Arg Trp Tyr His Arg Ala
2885 2890 2895
Val Thr Gly Ser Thr Glu Ala Cys His Pro Phe Val Tyr Gly Gly Cys
2900 2905 2910
Gly Gly Asn Ala Asn Arg Phe Gly Thr Arg Glu Ala Cys Glu Arg Arg
2915 2920 2925
Cys Pro Pro Arg Val Val Gln Ser Gln Gly Thr Gly Thr Ala Gln Asp
2930 2935 2940
<210> 27
<211> 119
<212> PRT
<213> Homo sapiens
<400> 27
Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys
1 5 10 15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro
20 25 30
Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr
35 40 45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu
50 55 60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu
65 70 75 80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His
85 90 95
Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn
100 105 110
Asp Lys Arg Ser Phe Cys His
115
<210> 28
<211> 1205
<212> PRT
<213> Homo sapiens
<400> 28
Met Val Lys Cys Tyr His Lys Lys Tyr Arg Ser Ala Thr Arg Asp Val
1 5 10 15
Ile Phe Arg Leu Gln Phe His Thr Gly Ala Val Gln Gly Tyr Gly Leu
20 25 30
Val Phe Gly Lys Glu Asp Leu Asp Asn Ala Ser Lys Asp Asp Arg Phe
35 40 45
Pro Asp Tyr Gly Lys Val Glu Leu Val Phe Ser Ala Thr Pro Glu Lys
50 55 60
Ile Gln Gly Ser Glu His Leu Tyr Asn Asp His Gly Val Ile Val Asp
65 70 75 80
Tyr Asn Thr Thr Asp Pro Leu Ile Arg Trp Asp Ser Tyr Glu Asn Leu
85 90 95
Ser Ala Asp Gly Glu Val Leu His Thr Gln Gly Pro Val Asp Gly Ser
100 105 110
Leu Tyr Ala Lys Val Arg Lys Lys Ser Ser Ser Asp Pro Gly Ile Pro
115 120 125
Gly Gly Pro Gln Ala Ile Pro Ala Thr Asn Ser Pro Asp His Ser Asp
130 135 140
His Thr Leu Ser Val Ser Ser Asp Ser Gly His Ser Thr Ala Ser Ala
145 150 155 160
Arg Thr Asp Lys Thr Glu Glu Arg Leu Ala Pro Gly Thr Arg Arg Gly
165 170 175
Leu Ser Ala Gln Glu Lys Ala Glu Leu Asp Gln Leu Leu Ser Gly Phe
180 185 190
Gly Leu Glu Asp Pro Gly Ser Ser Leu Lys Glu Met Thr Asp Ala Arg
195 200 205
Ser Lys Tyr Ser Gly Thr Arg His Val Val Pro Ala Gln Val His Val
210 215 220
Asn Gly Asp Ala Ala Leu Lys Asp Arg Glu Thr Asp Ile Leu Asp Asp
225 230 235 240
Glu Met Pro His His Asp Leu His Ser Val Asp Ser Leu Gly Thr Leu
245 250 255
Ser Ser Ser Glu Gly Pro Gln Ser Ala His Leu Gly Pro Phe Thr Cys
260 265 270
His Lys Ser Ser Gln Asn Ser Leu Leu Ser Asp Gly Phe Gly Ser Asn
275 280 285
Val Gly Glu Asp Pro Gln Gly Thr Leu Val Pro Asp Leu Gly Leu Gly
290 295 300
Met Asp Gly Pro Tyr Glu Arg Glu Arg Thr Phe Gly Ser Arg Glu Pro
305 310 315 320
Lys Gln Pro Gln Pro Leu Leu Arg Lys Pro Ser Val Ser Ala Gln Met
325 330 335
Gln Ala Tyr Gly Gln Ser Ser Tyr Ser Thr Gln Thr Trp Val Arg Gln
340 345 350
Gln Gln Met Val Val Ala His Gln Tyr Ser Phe Ala Pro Asp Gly Glu
355 360 365
Ala Arg Leu Val Ser Arg Cys Pro Ala Asp Asn Pro Gly Leu Val Gln
370 375 380
Ala Gln Pro Arg Val Pro Leu Thr Pro Thr Arg Gly Thr Ser Ser Arg
385 390 395 400
Val Ala Val Gln Arg Gly Val Gly Ser Gly Pro His Pro Pro Asp Thr
405 410 415
Gln Gln Pro Ser Pro Ser Lys Ala Phe Lys Pro Arg Phe Pro Gly Asp
420 425 430
Gln Val Val Asn Gly Ala Gly Pro Glu Leu Ser Thr Gly Pro Ser Pro
435 440 445
Gly Ser Pro Thr Leu Asp Ile Asp Gln Ser Ile Glu Gln Leu Asn Arg
450 455 460
Leu Ile Leu Glu Leu Asp Pro Thr Phe Glu Pro Ile Pro Thr His Met
465 470 475 480
Asn Ala Leu Gly Ser Gln Ala Asn Gly Ser Val Ser Pro Asp Ser Val
485 490 495
Gly Gly Gly Leu Arg Ala Ser Ser Arg Leu Pro Asp Thr Gly Glu Gly
500 505 510
Pro Ser Arg Ala Thr Gly Arg Gln Gly Ser Ser Ala Glu Gln Pro Leu
515 520 525
Gly Gly Arg Leu Arg Lys Leu Ser Leu Gly Gln Tyr Asp Asn Asp Ala
530 535 540
Gly Gly Gln Leu Pro Phe Ser Lys Cys Ala Trp Gly Lys Ala Gly Val
545 550 555 560
Asp Tyr Ala Pro Asn Leu Pro Pro Phe Pro Ser Pro Ala Asp Val Lys
565 570 575
Glu Thr Met Thr Pro Gly Tyr Pro Gln Asp Leu Asp Ile Ile Asp Gly
580 585 590
Arg Ile Leu Ser Ser Lys Glu Ser Met Cys Ser Thr Pro Ala Phe Pro
595 600 605
Val Ser Pro Glu Thr Pro Tyr Val Lys Thr Ala Leu Arg His Pro Pro
610 615 620
Phe Ser Pro Pro Glu Pro Pro Leu Ser Ser Pro Ala Ser Gln His Lys
625 630 635 640
Gly Gly Arg Glu Pro Arg Ser Cys Pro Glu Thr Leu Thr His Ala Val
645 650 655
Gly Met Ser Glu Ser Pro Ile Gly Pro Lys Ser Thr Met Leu Arg Ala
660 665 670
Asp Ala Ser Ser Thr Pro Ser Phe Gln Gln Ala Phe Ala Ser Ser Cys
675 680 685
Thr Ile Ser Ser Asn Gly Pro Gly Gln Arg Arg Glu Ser Ser Ser Ser
690 695 700
Ala Glu Arg Gln Trp Val Glu Ser Ser Pro Lys Pro Met Val Ser Leu
705 710 715 720
Leu Gly Ser Gly Arg Pro Thr Gly Ser Pro Leu Ser Ala Glu Phe Ser
725 730 735
Gly Thr Arg Lys Asp Ser Pro Val Leu Ser Cys Phe Pro Pro Ser Glu
740 745 750
Leu Gln Ala Pro Phe His Ser His Glu Leu Ser Leu Ala Glu Pro Pro
755 760 765
Asp Ser Leu Ala Pro Pro Ser Ser Gln Ala Phe Leu Gly Phe Gly Thr
770 775 780
Ala Pro Val Gly Ser Gly Leu Pro Pro Glu Glu Asp Leu Gly Ala Leu
785 790 795 800
Leu Ala Asn Ser His Gly Ala Ser Pro Thr Pro Ser Ile Pro Leu Thr
805 810 815
Ala Thr Gly Ala Ala Asp Asn Gly Phe Leu Ser His Asn Phe Leu Thr
820 825 830
Val Ala Pro Gly His Ser Ser His His Ser Pro Gly Leu Gln Gly Gln
835 840 845
Gly Val Thr Leu Pro Gly Gln Pro Pro Leu Pro Glu Lys Lys Arg Ala
850 855 860
Ser Glu Gly Asp Arg Ser Leu Gly Ser Val Ser Pro Ser Ser Ser Gly
865 870 875 880
Phe Ser Ser Pro His Ser Gly Ser Thr Ile Ser Ile Pro Phe Pro Asn
885 890 895
Val Leu Pro Asp Phe Ser Lys Ala Ser Glu Ala Ala Ser Pro Leu Pro
900 905 910
Asp Ser Pro Gly Asp Lys Leu Val Ile Val Lys Phe Val Gln Asp Thr
915 920 925
Ser Lys Phe Trp Tyr Lys Ala Asp Ile Ser Arg Glu Gln Ala Ile Ala
930 935 940
Met Leu Lys Asp Lys Glu Pro Gly Ser Phe Ile Val Arg Asp Ser His
945 950 955 960
Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ala Thr Pro Pro
965 970 975
Pro Ser Val Leu Gln Leu Asn Lys Lys Ala Gly Asp Leu Ala Asn Glu
980 985 990
Leu Val Arg His Phe Leu Ile Glu Cys Thr Pro Lys Gly Val Arg Leu
995 1000 1005
Lys Gly Cys Ser Asn Glu Pro Tyr Phe Gly Ser Leu Thr Ala Leu Val
1010 1015 1020
Cys Gln His Ser Ile Thr Pro Leu Ala Leu Pro Cys Lys Leu Leu Ile
1025 1030 1035 1040
Pro Glu Arg Asp Pro Leu Glu Glu Ile Ala Glu Ser Ser Pro Gln Thr
1045 1050 1055
Ala Ala Asn Ser Ala Ala Glu Leu Leu Lys Gln Gly Ala Ala Cys Asn
1060 1065 1070
Val Trp Tyr Leu Asn Ser Val Glu Met Glu Ser Leu Thr Gly His Gln
1075 1080 1085
Ala Ile Gln Lys Ala Leu Ser Ile Thr Leu Val Gln Glu Pro Pro Pro
1090 1095 1100
Val Ser Thr Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu
1105 1110 1115 1120
Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val Asn
1125 1130 1135
Ser Val Ile Phe Cys Ala Leu Asp Pro Gln Asp Arg Lys Trp Ile Lys
1140 1145 1150
Asp Gly Pro Ser Ser Lys Val Phe Gly Phe Val Ala Arg Lys Gln Gly
1155 1160 1165
Ser Ala Thr Asp Asn Val Cys His Leu Phe Ala Glu His Asp Pro Glu
1170 1175 1180
Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met Ile Gly
1185 1190 1195 1200
Ser Pro Lys Lys Val
1205
<210> 29
<211> 620
<212> PRT
<213> Homo sapiens
<400> 29
Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln
1 5 10 15
Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro
20 25 30
Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys
35 40 45
Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg
50 55 60
Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys
65 70 75 80
Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile
85 90 95
Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys
100 105 110
Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp
115 120 125
Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser
130 135 140
Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val
145 150 155 160
Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser
165 170 175
Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro
180 185 190
Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe
195 200 205
Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln
210 215 220
Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg
225 230 235 240
Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu
245 250 255
Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg
260 265 270
Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln
275 280 285
Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr
290 295 300
Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro
305 310 315 320
Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala
325 330 335
Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe
340 345 350
Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe
355 360 365
Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn
370 375 380
Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro
385 390 395 400
Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu
405 410 415
His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val
420 425 430
Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln
435 440 445
Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr
450 455 460
Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn
465 470 475 480
Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala
485 490 495
Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His
500 505 510
Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala
515 520 525
Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala
530 535 540
Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr
545 550 555 560
Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala
565 570 575
Ser Thr Tyr Ser Glu Phe Ala Lys Asp Pro Ser Leu Ser Asp Ser Ser
580 585 590
Thr Val Gly Leu Gln Arg Glu Leu Ser Lys Ala Ser Lys Ser Asp Ala
595 600 605
Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser
610 615 620
<210> 30
<211> 90
<212> PRT
<213> Homo sapiens
<400> 30
Met Arg Asp Pro Val Ser Ser Gln Tyr Ser Ser Phe Leu Phe Trp Arg
1 5 10 15
Met Pro Ile Pro Glu Leu Asp Leu Ser Glu Leu Glu Gly Leu Gly Leu
20 25 30
Ser Asp Thr Ala Thr Tyr Lys Val Lys Asp Ser Ser Val Gly Lys Met
35 40 45
Ile Gly Gln Ala Thr Ala Ala Asp Gln Glu Lys Asn Pro Glu Gly Asp
50 55 60
Gly Leu Leu Glu Tyr Ser Thr Phe Asn Phe Trp Arg Ala Pro Ile Ala
65 70 75 80
Ser Ile His Ser Phe Glu Leu Asp Leu Leu
85 90
<210> 31
<211> 763
<212> PRT
<213> Homo sapiens
<400> 31
Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu
1 5 10 15
Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro
20 25 30
Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys
35 40 45
Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile
50 55 60
Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn
65 70 75 80
Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys
85 90 95
Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly
100 105 110
Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser
115 120 125
Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys
130 135 140
Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys
145 150 155 160
Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr
165 170 175
Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser
180 185 190
Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu
195 200 205
Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg
210 215 220
Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser
225 230 235 240
Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg
245 250 255
Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr
260 265 270
Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn
275 280 285
Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys
290 295 300
Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu
305 310 315 320
Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu
325 330 335
His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn
340 345 350
Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys
355 360 365
Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro
370 375 380
Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro
385 390 395 400
Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg
405 410 415
Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro
420 425 430
Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu
435 440 445
Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile
450 455 460
Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu
465 470 475 480
Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu
485 490 495
Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg
500 505 510
Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser
515 520 525
Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser
530 535 540
Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu
545 550 555 560
Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro
565 570 575
Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln
580 585 590
Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile
595 600 605
Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp
610 615 620
Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val
625 630 635 640
Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu
645 650 655
Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser
660 665 670
Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro
675 680 685
Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser
690 695 700
Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu
705 710 715 720
Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu
725 730 735
Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn
740 745 750
Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln
755 760
<210> 32
<211> 464
<212> PRT
<213> Homo sapiens
<400> 32
Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser
1 5 10 15
Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly
20 25 30
Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys
35 40 45
Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg
50 55 60
Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys
65 70 75 80
Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser
85 90 95
Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu
100 105 110
Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu
115 120 125
Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser
130 135 140
Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe
145 150 155 160
Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp
165 170 175
Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu
180 185 190
Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys
195 200 205
Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu
210 215 220
Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu
225 230 235 240
Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr
245 250 255
Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr
260 265 270
Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg
275 280 285
Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile
290 295 300
Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu
305 310 315 320
Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr
325 330 335
Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu
340 345 350
Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu
355 360 365
Asp Arg Gln His Val Gln His Gln Leu Leu Val Ile Leu Lys Glu Leu
370 375 380
Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu
385 390 395 400
His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr
405 410 415
Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala
420 425 430
Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro
435 440 445
Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys
450 455 460
<210> 33
<211> 318
<212> PRT
<213> Homo sapiens
<400> 33
Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys
1 5 10 15
Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys
20 25 30
Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met
35 40 45
Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu
50 55 60
Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu
65 70 75 80
Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro
85 90 95
Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys
100 105 110
Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe
115 120 125
Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile
130 135 140
Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met
145 150 155 160
Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn
165 170 175
Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala
180 185 190
Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu
195 200 205
Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys
210 215 220
Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly
225 230 235 240
Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp
245 250 255
Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala
260 265 270
Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser
275 280 285
Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr
290 295 300
Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp
305 310 315
<210> 34
<211> 250
<212> PRT
<213> Homo sapiens
<400> 34
Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg
1 5 10 15
Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu
20 25 30
Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser
35 40 45
Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln
50 55 60
Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg
65 70 75 80
Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu
85 90 95
Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu
100 105 110
Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln
115 120 125
Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn
130 135 140
Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln
145 150 155 160
Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu
165 170 175
Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu
180 185 190
Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu
195 200 205
Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile
210 215 220
Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr
225 230 235 240
Val Asp Cys Gly Gly Asn Ser Thr Ala Ile
245 250
<210> 35
<211> 152
<212> PRT
<213> Homo sapiens
<400> 35
Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys
1 5 10 15
Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile
20 25 30
Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly
35 40 45
Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe
50 55 60
Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp
65 70 75 80
Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu
85 90 95
Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile
100 105 110
Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp
115 120 125
Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro
130 135 140
Thr Asp Pro Ala Asp Gly Pro Val
145 150
<210> 36
<211> 497
<212> PRT
<213> Homo sapiens
<400> 36
Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu
1 5 10 15
Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu
20 25 30
Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg
35 40 45
Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn
50 55 60
Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met
65 70 75 80
Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln
85 90 95
Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln
100 105 110
Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val
115 120 125
Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser
130 135 140
Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr
145 150 155 160
His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala
165 170 175
Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn
180 185 190
Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly
195 200 205
Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser
210 215 220
Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr
225 230 235 240
Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro
245 250 255
Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro
260 265 270
Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val
275 280 285
Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn
290 295 300
Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe
305 310 315 320
Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile
325 330 335
His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg
340 345 350
Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln
355 360 365
Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val
370 375 380
Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro
385 390 395 400
Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His
405 410 415
Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile
420 425 430
Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val
435 440 445
Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys
450 455 460
Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser
465 470 475 480
Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg
485 490 495
Gln
<210> 37
<211> 334
<212> PRT
<213> Homo sapiens
<400> 37
Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val
1 5 10 15
Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu
20 25 30
Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln
35 40 45
Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val
50 55 60
Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys
65 70 75 80
Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys
85 90 95
Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr
100 105 110
Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg
115 120 125
Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly
130 135 140
Ala Gly Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr
145 150 155 160
Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr
165 170 175
Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe
180 185 190
Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly
195 200 205
Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn
210 215 220
Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp
225 230 235 240
Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu
245 250 255
Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val
260 265 270
Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln
275 280 285
Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly
290 295 300
Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe
305 310 315 320
Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser
325 330
<210> 38
<211> 168
<212> PRT
<213> Homo sapiens
<400> 38
Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala
1 5 10 15
Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala
20 25 30
Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly
35 40 45
Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu
50 55 60
Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met
65 70 75 80
Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly
85 90 95
Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn
100 105 110
Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn
115 120 125
Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu
130 135 140
Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly
145 150 155 160
Lys Lys Gln Glu Lys Met Leu Asp
165
<210> 39
<211> 316
<212> PRT
<213> Homo sapiens
<400> 39
Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu
1 5 10 15
Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val
20 25 30
Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val
35 40 45
Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg
50 55 60
Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp
65 70 75 80
Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr
85 90 95
Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp
100 105 110
Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser
115 120 125
Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala
130 135 140
Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser
145 150 155 160
Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu
165 170 175
Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr
180 185 190
Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr
195 200 205
Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu
210 215 220
Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys
225 230 235 240
His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg
245 250 255
Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu
260 265 270
Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr
275 280 285
Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys
290 295 300
Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe
305 310 315
<210> 40
<211> 384
<212> PRT
<213> Homo sapiens
<400> 40
Met Ala Ile Ala Tyr Leu Gly Ser Ser Cys Pro Ser Gln Pro Pro Ser
1 5 10 15
Ser Leu Ala Leu Ser Leu Ser Pro Thr Pro Ser Asp Phe Glu Gln Glu
20 25 30
Ser Gly Ile Glu Thr Ala Met Arg Phe Ser Pro Asp Val Ala Leu Ala
35 40 45
Val Ser Thr Thr Pro Ala Val Leu Pro Thr Thr Asn Ile Gln Pro Val
50 55 60
Gly Thr Pro Phe Glu Glu Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro
65 70 75 80
Ala Thr Ser Pro Leu Val Val Thr Glu Val Pro Glu Glu Pro Ser Gln
85 90 95
Arg Ala Thr Thr Val Ser Thr Thr Met Ala Thr Thr Ala Ala Thr Ser
100 105 110
Thr Gly Asp Pro Thr Val Ala Thr Val Pro Ala Thr Val Ala Thr Ala
115 120 125
Thr Pro Ser Thr Pro Ala Ala Pro Pro Phe Thr Ala Thr Thr Ala Val
130 135 140
Ile Arg Thr Thr Gly Val Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr
145 150 155 160
Val Ala Thr Ala Arg Ala Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr
165 170 175
Thr Ala Ala Val Leu Asp Thr Glu Ala Pro Thr Pro Arg Leu Val Ser
180 185 190
Thr Ala Thr Ser Arg Pro Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln
195 200 205
Glu Pro Asp Ile Pro Glu Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala
210 215 220
Pro Gly Pro Thr Glu Val Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu
225 230 235 240
Thr Thr Ile Arg Asp Glu Pro Glu Val Pro Val Ser Gly Gly Pro Ser
245 250 255
Gly Asp Phe Glu Leu Pro Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala
260 265 270
Asn Glu Val Val Ala Val Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro
275 280 285
Pro Gly Thr Leu Pro Lys Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp
290 295 300
Asn Ala Ile Asp Ser Gly Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser
305 310 315 320
Ile Leu Glu Arg Lys Glu Val Leu Val Ala Val Ile Val Gly Gly Val
325 330 335
Val Gly Ala Leu Phe Ala Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg
340 345 350
Met Lys Lys Lys Asp Glu Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln
355 360 365
Ala Ser Val Thr Tyr Gln Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala
370 375 380
<210> 41
<211> 211
<212> PRT
<213> Homo sapiens
<400> 41
Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu
1 5 10 15
Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln
20 25 30
Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly
35 40 45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60
Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80
Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu
85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys
100 105 110
Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr
115 120 125
Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn
130 135 140
Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys
145 150 155 160
Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly
165 170 175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190
Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205
Thr Asp Pro
210
<210> 42
<211> 322
<212> PRT
<213> Homo sapiens
<400> 42
Met Leu Ser Pro Leu Pro Thr Gly Pro Leu Glu Ala Cys Phe Ser Val
1 5 10 15
Gln Ser Arg Thr Ser Ser Pro Met Glu Pro Pro Ile Pro Gln Ser Ala
20 25 30
Pro Leu Thr Pro Asn Ser Val Met Val Gln Pro Leu Leu Asp Ser Arg
35 40 45
Met Ser His Ser Arg Leu Gln His Pro Leu Thr Ile Leu Pro Ile Asp
50 55 60
Gln Val Lys Thr Ser His Val Glu Asn Asp Tyr Ile Asp Asn Pro Ser
65 70 75 80
Leu Ala Leu Thr Thr Gly Pro Lys Arg Thr Arg Gly Gly Ala Pro Glu
85 90 95
Leu Ala Pro Thr Pro Ala Arg Cys Asp Gln Asp Val Thr His His Trp
100 105 110
Ile Ser Phe Ser Gly Arg Pro Ser Ser Val Ser Ser Ser Ser Ser Thr
115 120 125
Ser Ser Asp Gln Arg Leu Leu Asp His Met Ala Pro Pro Pro Val Ala
130 135 140
Asp Gln Ala Ser Pro Arg Ala Val Arg Ile Gln Pro Lys Val Val His
145 150 155 160
Cys Gln Pro Leu Asp Leu Lys Gly Pro Ala Val Pro Pro Glu Leu Asp
165 170 175
Lys His Phe Leu Leu Cys Glu Ala Cys Gly Lys Cys Lys Cys Lys Glu
180 185 190
Cys Ala Ser Pro Arg Thr Leu Pro Ser Cys Trp Val Cys Asn Gln Glu
195 200 205
Cys Leu Cys Ser Ala Gln Thr Leu Val Asn Tyr Gly Thr Cys Met Cys
210 215 220
Leu Val Gln Gly Ile Phe Tyr His Cys Thr Asn Glu Asp Asp Glu Gly
225 230 235 240
Ser Cys Ala Asp His Pro Cys Ser Cys Ser Arg Ser Asn Cys Cys Ala
245 250 255
Arg Trp Ser Phe Met Gly Ala Leu Ser Val Val Leu Pro Cys Leu Leu
260 265 270
Cys Tyr Leu Pro Ala Thr Gly Cys Val Lys Leu Ala Gln Arg Gly Tyr
275 280 285
Asp Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser Val
290 295 300
Ile Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp Lys
305 310 315 320
Pro Phe
<210> 43
<211> 623
<212> PRT
<213> Homo sapiens
<400> 43
Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys
1 5 10 15
Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala
20 25 30
Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met
35 40 45
Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg
50 55 60
Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro
65 70 75 80
Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu
85 90 95
Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val
100 105 110
Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly
115 120 125
Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys
130 135 140
Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu
145 150 155 160
Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp
165 170 175
Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro
180 185 190
Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala
195 200 205
Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu
210 215 220
Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala
225 230 235 240
Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser
245 250 255
Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln
260 265 270
Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro
275 280 285
Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro
290 295 300
Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala
305 310 315 320
Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile
325 330 335
Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys
340 345 350
Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn
355 360 365
Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro
370 375 380
Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile
385 390 395 400
Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His
405 410 415
Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu
420 425 430
Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro
435 440 445
Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr
450 455 460
Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile
465 470 475 480
Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu
485 490 495
Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu
500 505 510
His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn
515 520 525
Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu
530 535 540
Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu
545 550 555 560
Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val
565 570 575
Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val
580 585 590
Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp
595 600 605
Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala
610 615 620
<210> 44
<211> 178
<212> PRT
<213> Homo sapiens
<400> 44
Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile
1 5 10 15
Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser
20 25 30
Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp
35 40 45
Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro
50 55 60
Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly
65 70 75 80
Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys
85 90 95
Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser
100 105 110
Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly
115 120 125
Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys
130 135 140
Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile
145 150 155 160
Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg
165 170 175
Cys Arg
<210> 45
<211> 228
<212> PRT
<213> Homo sapiens
<400> 45
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
1 5 10 15
Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
20 25 30
Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
35 40 45
Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
50 55 60
Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
65 70 75 80
Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
85 90 95
Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
100 105 110
His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
115 120 125
Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
130 135 140
Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145 150 155 160
Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
165 170 175
Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
180 185 190
Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
195 200 205
Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
210 215 220
Arg Glu Met Val
225
<210> 46
<211> 239
<212> PRT
<213> Homo sapiens
<400> 46
Met Ala Lys Pro Cys Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln
1 5 10 15
Val Glu Val Phe Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu
20 25 30
Tyr Arg Phe Leu Pro Gln Lys Ile Ile Tyr Leu Asn Gln Leu Leu Gln
35 40 45
Glu Asp Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu
50 55 60
Asp Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr
65 70 75 80
Asp Lys Gln Glu Lys Lys Glu Val His Lys Cys Gly Phe Leu Pro Gly
85 90 95
Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val Trp
100 105 110
Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile Gln His Leu
115 120 125
Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly Val Ala Ile Gln Glu
130 135 140
Lys Val Leu Glu Arg Val Asn Ala Val Lys Thr Lys Val Glu Ala Phe
145 150 155 160
Gln Thr Thr Ile Ser Lys Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala
165 170 175
Lys Ala Ser Lys Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His
180 185 190
Glu Arg Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp
195 200 205
Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn Leu
210 215 220
Glu Lys Ile Val Asn Pro Lys Gly Glu Glu Lys Pro Ser Met Tyr
225 230 235
<210> 47
<211> 672
<212> PRT
<213> Homo sapiens
<400> 47
Met Ala Asp Gly Ser Leu Thr Gly Gly Gly Leu Glu Ala Ala Ala Met
1 5 10 15
Ala Pro Glu Arg Thr Gly Trp Ala Val Glu Gln Glu Leu Ala Ser Leu
20 25 30
Glu Lys Gly Leu Phe Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr
35 40 45
Arg Asp Lys Pro Gly Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys
50 55 60
Thr Phe Phe Pro Glu Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu
65 70 75 80
Arg Phe Arg Ala Tyr Gln Asp Tyr Ile Leu Ala Asp Cys Lys Ala Ser
85 90 95
Glu Val Gln Glu Phe Thr Ala Glu Phe Leu Glu Lys Val Leu Glu Pro
100 105 110
Ser Gly Trp Arg Ala Val Trp His Thr Asn Val Phe Lys Val Leu Val
115 120 125
Glu Ile Thr Asp Val Asp Phe Ala Ala Leu Lys Ala Val Val Arg Leu
130 135 140
Ala Glu Pro Tyr Leu Cys Asp Ser Gln Val Ser Thr Phe Thr Met Glu
145 150 155 160
Cys Met Lys Glu Leu Leu Asp Leu Lys Glu His Arg Leu Pro Leu Gln
165 170 175
Glu Leu Trp Val Val Phe Asp Asp Ser Gly Val Phe Asp Gln Thr Ala
180 185 190
Leu Ala Ile Glu His Val Arg Phe Phe Tyr Gln Asn Ile Trp Arg Ser
195 200 205
Trp Asp Glu Glu Glu Glu Asp Glu Tyr Asp Tyr Phe Val Arg Cys Val
210 215 220
Glu Pro Arg Leu Arg Leu His Tyr Asp Ile Leu Glu Asp Arg Val Pro
225 230 235 240
Ser Gly Leu Ile Val Asp Tyr His Asn Leu Leu Ser Gln Cys Glu Glu
245 250 255
Ser Tyr Arg Lys Phe Leu Asn Leu Arg Ser Ser Leu Ser Asn Cys Asn
260 265 270
Ser Asp Ser Glu Gln Glu Asn Ile Ser Met Val Glu Gly Leu Lys Leu
275 280 285
Tyr Ser Glu Met Glu Gln Leu Lys Gln Lys Leu Lys Leu Ile Glu Asn
290 295 300
Pro Leu Leu Arg Tyr Val Phe Gly Tyr Gln Lys Asn Ser Asn Ile Gln
305 310 315 320
Ala Lys Gly Val Arg Ser Ser Gly Gln Lys Ile Thr His Val Val Ser
325 330 335
Ser Thr Met Met Ala Gly Leu Leu Arg Ser Leu Leu Thr Asp Arg Leu
340 345 350
Cys Gln Glu Pro Gly Glu Glu Glu Arg Glu Ile Gln Phe His Ser Asp
355 360 365
Pro Leu Ser Ala Ile Asn Ala Cys Phe Glu Gly Asp Thr Val Ile Val
370 375 380
Cys Pro Gly His Tyr Val Val His Gly Thr Phe Ser Ile Ala Asp Ser
385 390 395 400
Ile Glu Leu Glu Gly Tyr Gly Leu Pro Asp Asp Ile Val Ile Glu Lys
405 410 415
Arg Gly Lys Gly Asp Thr Phe Val Asp Cys Thr Gly Ala Asp Ile Lys
420 425 430
Ile Ser Gly Ile Lys Phe Val Gln His Asp Ala Val Glu Gly Ile Leu
435 440 445
Ile Val His Arg Gly Lys Thr Thr Leu Glu Asn Cys Val Leu Gln Cys
450 455 460
Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala Glu Phe Leu Met Lys
465 470 475 480
Asn Ser Asp Leu Tyr Gly Ala Lys Gly Ala Gly Ile Glu Ile Tyr Pro
485 490 495
Gly Ser Gln Cys Thr Leu Ser Asp Asn Gly Ile His His Cys Lys Glu
500 505 510
Gly Ile Leu Ile Lys Asp Phe Leu Asp Glu His Tyr Asp Ile Pro Lys
515 520 525
Ile Ser Met Val Asn Asn Ile Ile His Asn Asn Glu Gly Tyr Gly Val
530 535 540
Val Leu Val Lys Pro Thr Ile Phe Ser Asp Leu Gln Glu Ser Ala Glu
545 550 555 560
Asp Gly Thr Glu Glu Asn Lys Ala Leu Lys Ile Gln Thr Ser Gly Glu
565 570 575
Pro Asp Val Ala Glu Arg Val Asp Leu Glu Glu Leu Ile Glu Cys Ala
580 585 590
Thr Gly Lys Met Glu Leu Cys Ala Arg Thr Asp Pro Ser Glu Gln Val
595 600 605
Glu Gly Asn Cys Glu Ile Val Asn Glu Leu Ile Ala Ala Ser Thr Gln
610 615 620
Lys Gly Gln Ile Lys Lys Lys Arg Leu Ser Glu Leu Gly Ile Thr Gln
625 630 635 640
Ala Asp Asp Asn Leu Met Ser Gln Glu Met Phe Val Gly Ile Val Gly
645 650 655
Asn Gln Phe Lys Trp Asn Gly Lys Gly Ser Phe Gly Thr Phe Leu Phe
660 665 670
<210> 48
<211> 963
<212> PRT
<213> Homo sapiens
<400> 48
Met Ala Ala Gln Arg Ile Arg Ala Ala Asn Ser Asn Gly Leu Pro Arg
1 5 10 15
Cys Lys Ser Glu Gly Thr Leu Ile Asp Leu Ser Glu Gly Phe Ser Glu
20 25 30
Thr Ser Phe Asn Asp Ile Lys Val Pro Ser Pro Ser Ala Leu Leu Val
35 40 45
Asp Asn Pro Thr Pro Phe Gly Asn Ala Lys Glu Val Ile Ala Ile Lys
50 55 60
Asp Tyr Cys Pro Thr Asn Phe Thr Thr Leu Lys Phe Ser Lys Gly Asp
65 70 75 80
His Leu Tyr Val Leu Asp Thr Ser Gly Gly Glu Trp Trp Tyr Ala His
85 90 95
Asn Thr Thr Glu Met Gly Tyr Ile Pro Ser Ser Tyr Val Gln Pro Leu
100 105 110
Asn Tyr Arg Asn Ser Thr Leu Ser Asp Ser Gly Met Ile Asp Asn Leu
115 120 125
Pro Asp Ser Pro Asp Glu Val Ala Lys Glu Leu Glu Leu Leu Gly Gly
130 135 140
Trp Thr Asp Asp Lys Lys Val Pro Gly Arg Met Tyr Ser Asn Asn Pro
145 150 155 160
Phe Trp Asn Gly Val Gln Thr Asn Pro Phe Leu Asn Gly Asn Val Pro
165 170 175
Val Met Pro Ser Leu Asp Glu Leu Asn Pro Lys Ser Thr Val Asp Leu
180 185 190
Leu Leu Phe Asp Ala Gly Thr Ser Ser Phe Thr Glu Ser Ser Ser Ala
195 200 205
Thr Thr Asn Ser Thr Gly Asn Ile Phe Asp Glu Leu Pro Val Thr Asn
210 215 220
Gly Leu His Ala Glu Pro Pro Val Arg Arg Asp Asn Pro Phe Phe Arg
225 230 235 240
Ser Lys Arg Ser Tyr Ser Leu Ser Glu Leu Ser Val Leu Gln Ala Lys
245 250 255
Ser Asp Ala Pro Thr Ser Ser Ser Phe Phe Thr Gly Leu Lys Ser Pro
260 265 270
Ala Pro Glu Gln Phe Gln Ser Arg Glu Asp Phe Arg Thr Ala Trp Leu
275 280 285
Asn His Arg Lys Leu Ala Arg Ser Cys His Asp Leu Asp Leu Leu Gly
290 295 300
Gln Ser Pro Gly Trp Gly Gln Thr Gln Ala Val Glu Thr Asn Ile Val
305 310 315 320
Cys Lys Leu Asp Ser Ser Gly Gly Ala Val Gln Leu Pro Asp Thr Ser
325 330 335
Ile Ser Ile His Val Pro Glu Gly His Val Ala Pro Gly Glu Thr Gln
340 345 350
Gln Ile Ser Met Lys Ala Leu Leu Asp Pro Pro Leu Glu Leu Asn Ser
355 360 365
Asp Arg Ser Cys Ser Ile Ser Pro Val Leu Glu Val Lys Leu Ser Asn
370 375 380
Leu Glu Val Lys Thr Ser Ile Ile Leu Glu Met Lys Val Ser Ala Glu
385 390 395 400
Ile Lys Asn Asp Leu Phe Ser Lys Ser Thr Val Gly Leu Gln Cys Leu
405 410 415
Arg Ser Asp Ser Lys Glu Gly Pro Tyr Val Ser Val Pro Leu Asn Cys
420 425 430
Ser Cys Gly Asp Thr Val Gln Ala Gln Leu His Asn Leu Glu Pro Cys
435 440 445
Met Tyr Val Ala Val Val Ala His Gly Pro Ser Ile Leu Tyr Pro Ser
450 455 460
Thr Val Trp Asp Phe Ile Asn Lys Lys Val Thr Val Gly Leu Tyr Gly
465 470 475 480
Pro Lys His Ile His Pro Ser Phe Lys Thr Val Val Thr Ile Phe Gly
485 490 495
His Asp Cys Ala Pro Lys Thr Leu Leu Val Ser Glu Val Thr Arg Gln
500 505 510
Ala Pro Asn Pro Ala Pro Val Ala Leu Gln Leu Trp Gly Lys His Gln
515 520 525
Phe Val Leu Ser Arg Pro Gln Asp Leu Lys Val Cys Met Phe Ser Asn
530 535 540
Met Thr Asn Tyr Glu Val Lys Ala Ser Glu Gln Ala Lys Val Val Arg
545 550 555 560
Gly Phe Gln Leu Lys Leu Gly Lys Val Ser Arg Leu Ile Phe Pro Ile
565 570 575
Thr Ser Gln Asn Pro Asn Glu Leu Ser Asp Phe Thr Leu Arg Val Gln
580 585 590
Val Lys Asp Asp Gln Glu Ala Ile Leu Thr Gln Phe Cys Val Gln Thr
595 600 605
Pro Gln Pro Pro Pro Lys Ser Ala Ile Lys Pro Ser Gly Gln Arg Arg
610 615 620
Phe Leu Lys Lys Asn Glu Val Gly Lys Ile Ile Leu Ser Pro Phe Ala
625 630 635 640
Thr Thr Thr Lys Tyr Pro Thr Phe Gln Asp Arg Pro Val Ser Ser Leu
645 650 655
Lys Phe Gly Lys Leu Leu Lys Thr Val Val Arg Gln Asn Lys Asn His
660 665 670
Tyr Leu Leu Glu Tyr Lys Lys Gly Asp Gly Ile Ala Leu Leu Ser Glu
675 680 685
Glu Arg Val Arg Leu Arg Gly Gln Leu Trp Thr Lys Glu Trp Tyr Ile
690 695 700
Gly Tyr Tyr Gln Gly Arg Val Gly Leu Val His Thr Lys Asn Val Leu
705 710 715 720
Val Val Gly Arg Ala Arg Pro Ser Leu Cys Ser Gly Pro Glu Leu Ser
725 730 735
Thr Ser Val Leu Leu Glu Gln Ile Leu Arg Pro Cys Lys Phe Leu Thr
740 745 750
Tyr Ile Tyr Ala Ser Val Arg Thr Leu Leu Met Glu Asn Ile Ser Ser
755 760 765
Trp Arg Ser Phe Ala Asp Ala Leu Gly Tyr Val Asn Leu Pro Leu Thr
770 775 780
Phe Phe Cys Arg Ala Glu Leu Asp Ser Glu Pro Glu Arg Val Ala Ser
785 790 795 800
Val Leu Glu Lys Leu Lys Glu Asp Cys Asn Asn Thr Glu Asn Lys Glu
805 810 815
Arg Lys Ser Phe Gln Lys Glu Leu Val Met Ala Leu Leu Lys Met Asp
820 825 830
Cys Gln Gly Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr
835 840 845
Thr Ala Val Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu
850 855 860
Ala Lys Val Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg
865 870 875 880
Asp Arg Asn Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr
885 890 895
Asp Phe Leu Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp
900 905 910
Val Ile Gln Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile
915 920 925
Thr Lys Arg Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser
930 935 940
Leu Asp Val Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp
945 950 955 960
Phe Val Ile
<210> 49
<211> 359
<212> PRT
<213> Homo sapiens
<400> 49
Thr Asn Lys Leu Glu Gln Pro Arg Gly Gln Glu Phe Trp Ala Asp Leu
1 5 10 15
Asn Ala Met Asn Val Tyr Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg
20 25 30
Leu Ser Thr Pro Pro Ser Ser Asn Val Asn Ser Ile Tyr His Thr Val
35 40 45
Trp Lys Phe Phe Cys Arg Asp His Phe Gly Trp Arg Glu Tyr Pro Glu
50 55 60
Ser Val Ile Arg Leu Ile Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu
65 70 75 80
Val Arg Phe Met Met Trp Asn Asn His Tyr Ile Leu His Asn Ser Phe
85 90 95
Phe Arg Arg Glu Ile Lys Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile
100 105 110
Leu Leu Pro Tyr Leu Gln Thr Leu Gly Gly Val Pro Thr Gln Ala Pro
115 120 125
Pro Pro Leu Glu Ala Thr Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly
130 135 140
Val Thr Ser Ala Asn Phe Tyr Pro Glu Thr Trp Val Tyr Met His Pro
145 150 155 160
Ser Gln Asp Phe Ile Gln Val Pro Val Ser Ala Glu Asp Lys Ser Tyr
165 170 175
Arg Ile Ile Tyr Asn Leu Phe His Lys Thr Val Pro Glu Phe Lys Tyr
180 185 190
Arg Ile Leu Gln Ile Leu Arg Val Gln Asn Gln Phe Leu Trp Glu Lys
195 200 205
Tyr Lys Arg Lys Lys Glu Tyr Met Asn Arg Lys Met Phe Gly Arg Asp
210 215 220
Arg Ile Ile Asn Glu Arg His Leu Phe His Gly Thr Ser Gln Asp Val
225 230 235 240
Val Asp Gly Ile Cys Lys His Asn Phe Asp Pro Arg Val Cys Gly Lys
245 250 255
His Ala Thr Met Phe Gly Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser
260 265 270
Tyr Ser His Asn Phe Ser Lys Lys Ser Ser Lys Gly Val His Phe Met
275 280 285
Phe Leu Ala Lys Val Leu Thr Gly Arg Tyr Thr Met Gly Ser His Gly
290 295 300
Met Arg Arg Pro Pro Pro Val Asn Pro Gly Ser Val Thr Ser Asp Leu
305 310 315 320
Tyr Asp Ser Cys Val Asp Asn Phe Phe Glu Pro Gln Ile Phe Val Ile
325 330 335
Phe Asn Asp Asp Gln Ser Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu
340 345 350
Val Ser Asn Thr Val Ser Ile
355
Claims (2)
- 서열번호 1에서 서열번호 25로 구성된 군으로부터 선택된 하나의 모낭형성 능력을 갖는 유전자.
- 콜라겐형 VII(서열번호26), DNA 바인딩 3 저해제(서열번호27), 종양 엔도쎄리얼 마커 6(서열번호28), 사이토키네시스1의 단백질 조절자(서열번호 29), 염색체1q(ch 1q)의 올(ALL)1-융합된 유전자를 코딩하는 단백질(서열번호 30), 포크헤드 박스 M1(서열번호31), 가상(hypothetical) 단백질 FLJ10540(서열번호32), 감마-굴루타밀 하이드로레이즈(서열번호33), 가상 단백질 MGC5576(서열번호34), 프로테오리피드 단백질 2(서열번호35), 가상 단백질 DKFZp434B044(서열번호36), S-아데노실메티오닌 디카르복실레이즈 1(서열번호37), 프레이오트로핀(서열번호38), 알도-케토·리덕테이즈 B1(서열번호39), 신데칸 3(서열번호40), 메탈로프로테이즈 3 조직 인히비터(TIMP-3)(서열번호41), 스프로티 호모로지 4(서열번호42), 트랜스케토레이즈(서열번호43), FXYD 도메인 5(서열번호44), CD9 항원(p24)(서열번호45) 및 프로테오좀 액티베이터 단위체2(서열번호46), 가상 단백질 FLJ22009(서열번호47), SH3-도메인(서열번호48) 및 DKFZp434J214(서열번호49) 단백질로 구성된 군으로부터 선택된 하나의 모낭형성능력을 갖는 단백질.
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