KR102195319B1 - 상처치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법 - Google Patents
상처치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법 Download PDFInfo
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Abstract
본 발명은 상처 치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법 등에 관한 것으로서, 본 발명자들은 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위해 예의 연구한 결과, 상처 치유 물질로 사용되는 표피세포 증식인자(EGF; epithelial growth factor) 자극에 의해 발현된 섬유아세포를 cDNA microarray를 통해 분석한 뒤 유전자 목록을 확보하고, 기존의 키트에 포함된 유전자들을 분석한 다음 새로운 92개의 유전자 목록을 구축하였는 바, 상기 유전자 목록을 이용한 상보적인 프라이머 세트 등을 통하여 상처 치료제 스크리닝용 키트 등을 제작 활용할 수 있다. 또한, 수많은 천연물에서 유래한 제제나 인위적으로 합성된 작은 분자나 펩타이드로부터 상처치료 후보 물질을 상기 키트 등을 통하여 신속하게 탐색하고 평가할 수 있는 바 경제적이고 시간적 소비를 줄여, 효율적으로 상처 치료제를 개발할 수 있을 것으로 예상되며, 임상에서 만성 창상이나 급성 창상의 치료 예후 평가에도 활용될 수 있을 것으로 기대된다.
Description
본 발명은 상처 치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법에 관한 것으로서, 보다 구체적으로는 상처 치료 관련 유전자에 상보적인 프라이머 등 또는 상처 치료 관련 단백질에 특이적으로 결합하는 항체 등을 포함하는 상처 치료제 스크리닝용 조성물, 이를 포함하는 키트, 이를 이용한 상처 치료제 스크리닝 방법 및 상처 치료 관련 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물에 관한 것이다.
피부는 전체 인체 질량의 15~20%를 차지하는 조직임과 동시에 일차 방어막으로서 온도와 습도의 변화, 자외선, 오염 물질 등 외부환경에 의한 자극으로부터 보호해 주며, 인체 항상성 유지에 중요한 역할을 한다. 피부는 표피층(epidermis), 진피층(dermis), 피하지방층(subcutaneous fat tissue) 세 층으로 나눌 수 있다.
표피는 피부의 가장 외측에 존재하며 비교적 방수성이 있고 대부분의 세포는 각질 형성세포들로 표피의 가장 깊은 층에 있는 기저층에 위치한 세포에서 시작하여 표피층으로 올라가면서 세포의 생명력이 없어지며, 견고하고 규칙적인 세포층으로 변하게 되고 피부 표면에 도달하면 떨어져 나가게 된다. 표피는 내부 조직 및 장기를 각종 외상으로부터 보호하며, 물리적 및 면역학적 측면에서 많은 병원균등 외부 물질이 신체에 침투하는 것을 방어하는 역할을 한다. 피부의 표면에 상처가 생길 경우, 표피의 빠른 재생 능력으로 인한 상처의 회복을 촉진하여 추가 감염을 방지하는 역할을 한다. 진피는 피부를 유지하는 조직으로 신경말단, 땀샘, 피지선을 포함한 각 종 분비선 및 혈관 등의 다양한 기관이 있다. 피부의 섬유아세포 (fibroblast)에서 생성되는 주요 기질 단백질 중 콜라겐은 생체 단백질 총 중량의 약 30%를 차지하며 피부의 진피에 대부분이 존재한다. 그러므로 콜라겐은 상처 치료에서 중요한 역할을 담당한다고 할 수 있다.
상처받은 피부 조직은 자연적인 일련의 치유과정으로 각종 세포와 인자가 관여하여 매우 복잡한 반응이다. 상처 치유 과정은 크게 염증단계, 상피화단계, 증식단계, 성숙단계의 4단계로 나뉘며, 이들 단계는 중첩되어 연속적으로 진행된다. 이는 각 과정에서 나타나는 세포들과 이들 세포에서 분비되는 각종 세포 증식인자가 혈관내피, 탐색세포, 섬유아세포, 상피세포 등에 자극을 주어 세포 증식을 유도하며, 이들 세포는 자체적으로 분비하는 섬유아세포 증식, 형질전환 증식인자, 인터류킨 등의 물질을 생산하여 상처치유가 된다.
그러나, 다양한 상처 치료 제제를 개발 과정에 많은 경제적, 시간적으로 소비가 되는 상태이고, 기존의 상처 치유 관련 유전자를 이용한 실시간 유전자 중합반응 키트를 판매하고 있지만, 이는 단지 기존에 보고되었던 상처 치유 관련 유전자를 나열하는 식에 불과한 실정이었다. 즉, 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위한 연구 및 개발이 부족한 실정이었다.
본 발명은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH(이하, 92개의 유전자들)로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공하는 것을 목적으로 한다.
또한,본 발명은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH의 유전자로부터 코딩되는 단백질(이하, 92개의 단백질들)로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 상처 치료제 스크리닝용 조성물을 제공하는 것을 목적으로 한다.
또한, 본 발명은 상기 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공하는 것을 목적으로 한다.
또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;(b) 상기 섬유아세포에서 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c) 상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공하는 것을 목적으로 한다.
또한, 본 발명은 상기 92개 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공하는 것을 목적으로 한다.
그러나, 본 발명이 이루고자 하는 기술적 과제는 이상에서 언급한 과제에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 본 발명이 속하는 기술 분야의 통상의 지식을 가진 자에게 명확하게 이해될 수 있을 것이다.
상기와 같은 본 발명의 목적을 달성하기 위하여,
본 발명은 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.
본 발명의 일 구현 예로, 상기 프로브 세트는 형광 표지 물질을 갖는 표지 프로브 세트일 수 있다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는 상처 치료제 스크리닝용 조성물을 제공한다.
또한, 본 발명은 상기 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공한다.
또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계; (b) 상기 섬유아세포에서 상기 92개 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c)상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공한다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공한다.
본 발명의 일 구현 예로, 상기 단백질은 VISFATIN 또는 STC1 단백질일 수 있다.
본 발명의 또 다른 구현 예로, 상기 상처 치료용 약학적 조성물은ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시킬 수 있다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 약학적 조성물을 개체에 투여하는 단계를 포함하는, 상처 예방 또는 치료방법을 제공한다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 약학적 조성물의 상처 예방 또는 치료용도를 제공한다.
본 발명자들은 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위해 예의 연구한 결과, 상처 치유 물질로 사용되는 표피세포 증식인자(EGF; epithelial growth factor) 자극에 의해 발현된 섬유아세포를 cDNA microarray를 통해 분석한 뒤 유전자 목록을 확보하고, 기존의 키트에 포함된 유전자들을 분석한 다음 새로운 92개의 유전자 목록을 구축하였는 바, 상기 유전자 목록을 이용한 상보적인 프라이머 세트 등을 통하여 상처 치료제 스크리닝용 키트 등을 제작 활용할 수 있다. 또한, 수많은 천연물에서 유래한 제제나 인위적으로 합성된 작은 분자나 펩타이드로부터 상처치료 후보 물질을 상기 키트 등을 통하여 신속하게 탐색하고 평가할 수 있는 바 경제적이고 시간적 소비를 줄여, 효율적으로 상처 치료제를 개발할 수 있을 것으로 예상되고, 임상에서 만성 창상이나 급성 창상의 치료 예후 평가에도 활용될 수 있을 것으로 기대되며, 발굴된 92개의 유전자의 실질적인 상처치유 효과를 조사하여 새로운 상처치료제로서의 역할을 밝혀낼 수 있는 바, 상처치료제 시장에 유용할 것으로 기대된다.
도 1은 cDNA microarray를 이용하여 발굴한 상처치료에 관련된 92개의 유전자를 표로 나타낸 것이다.
도 2a 및 2b는 도 1에서 발굴한 92개 유전자 중 2개의 유전자로부터 발현된 VISFATIN 단백질(도 2a)과 STC1 단백질(도 2b)의 세포증식 효과를 BrdU 어세이를 통해 확인한 결과를 그래프로 나타낸 것이다.
도 3a 및 3b는 상기 VISFATIN 단백질(도 3a)과 STC1 단백질(도 3b)의 세포 이동능력 증가를 확인하기 위하여, 스크래치 어세이를 통해 확인한 결과를 염색된 세포 이미지 및 그래프로 나타낸 것이다.
도 4a 및 4b는 상기 VISFATIN 단백질(도 4a) 과 STC1 단백질(도 4b)이 상처 치유 능력을 향상시키는 지를 확인하기 위하여, 마우스 동물 급성창상 모델에서 창상의 치유변화를 이미지 및 그래프로 나타낸 것이다.
도 5는 마우스 급성창상 모델에서 상처 치유를 향상시키는 원인을 확인하기 위하여, 헤마톡실린&에오신(H&E) 조직염색을 통해 epithelial tongue의 증가를 이미지 및 그래프로 나타낸 것이다. 또한, 조직 내 혈관내피성장인자인 VEGF의 발현을 측정한 결과를 VEGF 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.
도 6은 VEGF의 발현증가와 관련된 분자적 메커니즘을 확인하기 위하여, ERK 및 JNK의 발현을 측정한 결과를 각각 인산화-ERK와 인산화-JNK 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.
도 2a 및 2b는 도 1에서 발굴한 92개 유전자 중 2개의 유전자로부터 발현된 VISFATIN 단백질(도 2a)과 STC1 단백질(도 2b)의 세포증식 효과를 BrdU 어세이를 통해 확인한 결과를 그래프로 나타낸 것이다.
도 3a 및 3b는 상기 VISFATIN 단백질(도 3a)과 STC1 단백질(도 3b)의 세포 이동능력 증가를 확인하기 위하여, 스크래치 어세이를 통해 확인한 결과를 염색된 세포 이미지 및 그래프로 나타낸 것이다.
도 4a 및 4b는 상기 VISFATIN 단백질(도 4a) 과 STC1 단백질(도 4b)이 상처 치유 능력을 향상시키는 지를 확인하기 위하여, 마우스 동물 급성창상 모델에서 창상의 치유변화를 이미지 및 그래프로 나타낸 것이다.
도 5는 마우스 급성창상 모델에서 상처 치유를 향상시키는 원인을 확인하기 위하여, 헤마톡실린&에오신(H&E) 조직염색을 통해 epithelial tongue의 증가를 이미지 및 그래프로 나타낸 것이다. 또한, 조직 내 혈관내피성장인자인 VEGF의 발현을 측정한 결과를 VEGF 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.
도 6은 VEGF의 발현증가와 관련된 분자적 메커니즘을 확인하기 위하여, ERK 및 JNK의 발현을 측정한 결과를 각각 인산화-ERK와 인산화-JNK 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.
본 발명자들은 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위해 예의 연구한 결과, 상처 치유 물질로 사용되는 표피세포 증식인자(EGF; epithelial growth factor) 자극에 의해 발현된 섬유아세포를 cDNA microarray를 통해 분석한 뒤 유전자 목록을 확보하고, 기존의 키트에 포함된 유전자들을 분석한 다음 새로운 92개의 유전자 목록을 구축하였는 바, 상기 유전자 목록을 이용한 상보적인 프라이머 세트 등을 통하여 상처 치료제 스크리닝용 키트 등을 제작 활용하여, 상처치료 후보 물질을 신속하게 탐색할 수 있고, 이와 동시에 상처치료 후보 물질이 영향을 미치는 유전자 타겟을 확보할 수 있다는 것을 확인하고 본 발명을 완성하였다.
이하, 본 발명을 자세히 설명한다.
본 발명은 ACTA2(alpha-action-2), BMPER(BMP binding endothelial regulator), CCL2(chemokine ligand 2), CH25H(cholesterol 25-hydroxylase), COL1A1(collagen type I alpha 1 chain), COL1A2(collagen type I alpha 2 chain), COL3A1(collagen type III alpha 1 chain), COL4A1(collagen type IV alpha 1 chain), COL5A1(collagen type V alpha 1 chain), COL5A2(collagen type V alpha 2 chain), CSF3(colony-stimulating factor 3), CTGF(connective tissue growth factor), CTNNB1, CTSK(catherpsin K), CXCL1(c-x-c motif chemokine ligand 1), CXCL5(c-x-c motif chemokine ligand 5), CXCL6(c-x-c motif chemokine ligand 6), DUSP6(dual specificity phosphatase 6), EGFR(epidermal growth factor receptor), EGR1(early growth response 1), EMP1(epithelial membrane protein 1), ENO1(enolase 1), ERRFI1(ERBB receptor feedback inhibitor 1), ESM1(endothelial cell specific molecule 1), FGA(fibrinogen alpha chain), FGF2(fibroblast growth factor 2), FGF7(fibroblast growth factor 7), FGF10(fibroblast growth factor 10), FOSL1(FOS like 1, AP-1 transcription factor subunit), FST(follistatin), HAS2(hyaluronan synthase 2), HBEGF(heparin binding EGF like growth factor), HGF(hepatocyte growth factor), HMGA2(high mobility group AT-hook 2), ICAM1(intercellular adhesion molecule 1), IER3(immediate early response 3), IL-13RA2(interleukin 13 receptor, alpha 2), IL-33(interleukin 33), IL-1B(interleukin 1 beta), IL-6(interleukin 6), IL-6ST(interleukin 6 signal transducer), IL-7R(interleukin 7 receptor), IL-8(interleukin 8), ITGA1(integrin subunit alpha 1), ITGA2(integrin subunit alpha 2), ITGA3(integrin subunit alpha 3), ITGA4(integrin subunit alpha 4), ITGA5(integrin subunit alpha 5), ITGAV(integrin subunit alpha V), ITGB1(integrin subunit beta 1), ITGB3(integrin subunit beta 3), ITGB5(integrin subunit beta 5), KRTAP1-5(keratin associated protein 1-5), LPXN(leupaxin), MAPK1(mitogen-activated protein kinase 1), MAPK3(mitogen-activated protein kinase 3), MCL1(MCL1, BCL2 family apoptosis regulator), MIF(macrophage migration inhibitory factor), MMP1(matrix metallopeptidase 1), MMP2(matrix metallopeptidase 2), MMP3(matrix metallopeptidase 3), VISFATIN(NAMPT;nicotinamide phosphoribosyltransferase), NPAS2(neuronal PAS domain protein 2), PDGFA(platelet derived growth factor subunit A), PLAT(plasminogen activator, tissue type), PLAU(plasminogen activator, urokinase), PLAUR(plasminogen activator, urokinase receptor), PLG(plasminogen), PTEN(phosphatase and tensin homolog), PTGS2(prostaglandin-endoperoxide synthase 2), PTX3(pentraxin 3), RAC1(Rac family small GTPase 1), RHOA(ras homolog family member A), SERPINB2(serpin family B member 2), SERPINE1(serpin family E member 1), SERPINE2(serpin family E member 2), SLC20A1(solute carrier family 20 member 1), SLIT2(slit guidance ligand 2), SMURF2(SMAD specific E3 ubiquitin protein ligase 2), STAT3(signal transducer and activator of transcription 3), STC1(stanniocalcin 1), SDC4(syndecan 4), TAGLN(transgelin), TFPI2(tissue factor pathway inhibitor 2),TGFB1(transforming growth factor beta 1), TGFBR3(transforming growth factor beta receptor 3), TIMP1(TIMP metallopeptidase inhibitor 1), TMEM158(transmembrane protein 158), TNFAIP6(TNF alpha induced protein 6), VEGFA(vascular endothelial growth factor A), WNT5A(Wnt family member 5A), 및 GAPDH(glyceraldehyde-3-phosphate dehydrogenase)로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.
본 발명에서, 상기 상처 관련 유전자 92개는 cDNA 마이크로어레이 기술에 의해 확보되었다. 보다 더 구체적으로, 본 발명가들은 표피성장인자인 epidermal growth factor(EGF) 자극에 의한 상처치유에 밀접하게 관련된 skin dermal fibroblasts(피부 섬유아세포)의 반응으로 인한 유전자 발현의 변화를 알아보기 위해, 인간의 피부 섬유아세포에 표피성장인자인 EGF 단백질을 1, 10, 50 ng/mL 농도로 12시간 처리하였다. 그 후, 세포로부터 mRNA를 분리하여 0.5μg의 mRNA를 사용하여 cDNA를 합성하였다. 합성된 cDNA는 Affymetrix사의 GeneChip Human Gene 2.0 ST Array를 실시하고 유전자 발현의 증감을 분석하였다. 그 결과, 총 40,716개의 전사유전자 중 1ng/mL, 10ng/mL, 50ng/mL를 피부 섬유아세포에 12시간 동안 처리했을 때, 각각 294, 890, 667개의 2 배 이상 상향 조절된 유전자를 확인하였다. 분석된 2배 이상 상향 조절된 유전자들은 다시, 다음 몇 가지 기준에 의해서 2차 분석되었다. 먼저, chip의 결과에서 기본적으로 높은 시그널을 보인 유전자, 아직 상처치유에 관련되어 있지 않거나, 활발하게 보고 되어 기존에 상처 치유에 관련한 유전자 키드에 포함 되었거나 되어 있지 않은 유전자를 분석하여 총 92개의 유전자를 확보하였다.
본 발명에서 사용되는 용어, "cDNA 마이크로어레이 기술"은 다양한 암, 감염병, 면역질환 등의 질병에 관련한 유전자 마커들을 확보하기 위해 사용한다. 이를 토대로 많은 질병을 보다 용이하게 진단하거나 예측하고, 질병 치료 제제의 효능을 효과적으로 탐색할 수 있다.
본 발명에서 사용되는 용어,"프라이머"는 적합한 온도에서 적합한 버퍼 내에서 적합한 조건(예를들면, 4종의 다른 뉴클레오시드 트리포스페이트 및 중합반응효소)에서 주형 - 지시 DNA 합성의 개시점으로 작용할 수 있는 단일 가닥의 올리고뉴클레오티드를 의미한다. 프라이머의 적합한 길이는 다양한 인자, 예를 들어, 온도와 프라이머의 용도에 따라 차이가 있지만, 전형적으로 15-35개의 뉴클레오티드이다. 짧은 프라이머는 주형과 충분히 안정된 혼성화 복합체를 형성하기 위하여 일반적으로 보다 낮은 온도를 요구할 수 있다. 용어 "정방향 프라이머(forward primer)" 및 "역방향 프라이머(reverseprimer)"는 중합효소 연쇄반응에 의해 증폭되는 주형의 일정한 부위의 3' 말단 및 5' 말단에 각각 결합하는 프라이머를 의미한다. 상기 프라이머는 주형의 한 부위에 혼성화 또는 어닐링되어, 이중 쇄 구조를 형성할 수 있다. 이러한 이중 쇄 구조를 형성하는데 적합한 핵산 혼성화의 조건은 당업자에게 잘 알려져 있으나 이에 제한되지 않는다.
본 발명에 있어서, 상기 프라이머 세트는 서열번호 1 및 서열번호 2로 표시되는 염기서열로 이루어진 ACTA2검출용 프라이머 세트, 서열번호 3 및 서열번호 4로 표시되는 염기서열로 이루어진 BMPER검출용 프라이머 세트, 서열번호 5 및 서열번호 6로 표시되는 염기서열로 이루어진 CCL2검출용 프라이머 세트, 서열번호 7 및 서열번호 8로 표시되는 염기서열로 이루어진 CH25H검출용 프라이머 세트, 서열번호 9 및 서열번호 10로 표시되는 염기서열로 이루어진 COL1A1검출용 프라이머 세트, 서열번호 11 및 서열번호 12로 표시되는 염기서열로 이루어진 COL1A2검출용 프라이머 세트, 서열번호 13 및 서열번호 14로 표시되는 염기서열로 이루어진 COL3A1검출용 프라이머 세트, 서열번호 15 및 서열번호 16로 표시되는 염기서열로 이루어진 COL4A1검출용 프라이머 세트, 서열번호 17 및 서열번호 18로 표시되는 염기서열로 이루어진 COL5A1검출용 프라이머 세트, 서열번호 19 및 서열번호 20로 표시되는 염기서열로 이루어진 COL5A2검출용 프라이머 세트, 서열번호 21 및 서열번호 22로 표시되는 염기서열로 이루어진 CSF3검출용 프라이머 세트, 서열번호 23 및 서열번호 24로 표시되는 염기서열로 이루어진 CTGF검출용 프라이머 세트, 서열번호 25 및 서열번호 26로 표시되는 염기서열로 이루어진 CTNNB1검출용 프라이머 세트, 서열번호 27 및 서열번호 28로 표시되는 염기서열로 이루어진 CTSK검출용 프라이머 세트, 서열번호 29 및 서열번호 30로 표시되는 염기서열로 이루어진 CXCL1검출용 프라이머 세트, 서열번호 31 및 서열번호 32로 표시되는 염기서열로 이루어진 CXCL5검출용 프라이머 세트, 서열번호 33 및 서열번호 34로 표시되는 염기서열로 이루어진 CXCL6검출용 프라이머 세트, 서열번호 35 및 서열번호 36로 표시되는 염기서열로 이루어진 DUSP6검출용 프라이머 세트, 서열번호 37 및 서열번호 38로 표시되는 염기서열로 이루어진 EGFR검출용 프라이머 세트, 서열번호 39 및 서열번호 40로 표시되는 염기서열로 이루어진 EGR1검출용 프라이머 세트, 서열번호 41 및 서열번호 42로 표시되는 염기서열로 이루어진 EMP1검출용 프라이머 세트, 서열번호 43 및 서열번호 44로 표시되는 염기서열로 이루어진 ENO1검출용 프라이머 세트, 서열번호 45 및 서열번호 46로 표시되는 염기서열로 이루어진 ERRFI1검출용 프라이머 세트, 서열번호 47 및 서열번호 48로 표시되는 염기서열로 이루어진 ESM1검출용 프라이머 세트, 서열번호 49 및 서열번호 50로 표시되는 염기서열로 이루어진 FGA검출용 프라이머 세트, 서열번호 51 및 서열번호 52로 표시되는 염기서열로 이루어진 FGF10검출용 프라이머 세트, 서열번호 53 및 서열번호 54로 표시되는 염기서열로 이루어진 FGF2검출용 프라이머 세트, 서열번호 55 및 서열번호 56로 표시되는 염기서열로 이루어진 FGF7검출용 프라이머 세트, 서열번호 57 및 서열번호 58로 표시되는 염기서열로 이루어진 FOSL1검출용 프라이머 세트, 서열번호 59 및 서열번호 60로 표시되는 염기서열로 이루어진 FST검출용 프라이머 세트, 서열번호 61 및 서열번호 62로 표시되는 염기서열로 이루어진 HAS2검출용 프라이머 세트, 서열번호 63 및 서열번호 64로 표시되는 염기서열로 이루어진 HBEGF검출용 프라이머 세트, 서열번호 65 및 서열번호 66로 표시되는 염기서열로 이루어진 HGF검출용 프라이머 세트, 서열번호 67 및 서열번호 68로 표시되는 염기서열로 이루어진 HMGA2검출용 프라이머 세트, 서열번호 69 및 서열번호 70로 표시되는 염기서열로 이루어진 ICAM1검출용 프라이머 세트, 서열번호 71 및 서열번호 72로 표시되는 염기서열로 이루어진 IER3검출용 프라이머 세트, 서열번호 73 및 서열번호 74로 표시되는 염기서열로 이루어진 IL-13RA2검출용 프라이머 세트, 서열번호 75 및 서열번호 76로 표시되는 염기서열로 이루어진 IL-33검출용 프라이머 세트, 서열번호 77 및 서열번호 78로 표시되는 염기서열로 이루어진 IL-1B검출용 프라이머 세트, 서열번호 79 및 서열번호 80로 표시되는 염기서열로 이루어진 IL-6검출용 프라이머 세트, 서열번호 81 및 서열번호 82로 표시되는 염기서열로 이루어진 IL-6ST검출용 프라이머 세트, 서열번호 83 및 서열번호 84로 표시되는 염기서열로 이루어진 IL-7R검출용 프라이머 세트, 서열번호 85 및 서열번호 86로 표시되는 염기서열로 이루어진 IL-8검출용 프라이머 세트, 서열번호 87 및 서열번호 88로 표시되는 염기서열로 이루어진 ITGA1검출용 프라이머 세트, 서열번호 89 및 서열번호 90로 표시되는 염기서열로 이루어진 ITGA2검출용 프라이머 세트, 서열번호 91 및 서열번호 92로 표시되는 염기서열로 이루어진 ITGA3검출용 프라이머 세트, 서열번호 93 및 서열번호 94로 표시되는 염기서열로 이루어진 ITGA4검출용 프라이머 세트, 서열번호 95 및 서열번호 96로 표시되는 염기서열로 이루어진 ITGA5검출용 프라이머 세트, 서열번호 97 및 서열번호 98로 표시되는 염기서열로 이루어진 ITGAV검출용 프라이머 세트, 서열번호 99 및 서열번호 100로 표시되는 염기서열로 이루어진 ITGB1검출용 프라이머 세트, 서열번호 101 및 서열번호 102로 표시되는 염기서열로 이루어진 ITGB3검출용 프라이머 세트, 서열번호 103 및 서열번호 104로 표시되는 염기서열로 이루어진 ITGB5검출용 프라이머 세트, 서열번호 105 및 서열번호 106로 표시되는 염기서열로 이루어진 KRTAP1-5검출용 프라이머 세트, 서열번호 107 및 서열번호 108로 표시되는 염기서열로 이루어진 LPXN검출용 프라이머 세트, 서열번호 109 및 서열번호 1110로 표시되는 염기서열로 이루어진 MAPK1검출용 프라이머 세트, 서열번호 111 및 서열번호 112로 표시되는 염기서열로 이루어진 MAPK3검출용 프라이머 세트, 서열번호 113 및 서열번호 114로 표시되는 염기서열로 이루어진 MCL1검출용 프라이머 세트, 서열번호 115 및 서열번호 116로 표시되는 염기서열로 이루어진 MIF검출용 프라이머 세트, 서열번호 117 및 서열번호 118로 표시되는 염기서열로 이루어진 MMP1검출용 프라이머 세트, 서열번호 119 및 서열번호 120로 표시되는 염기서열로 이루어진 MMP2검출용 프라이머 세트, 서열번호 121 및 서열번호 122로 표시되는 염기서열로 이루어진 MMP3검출용 프라이머 세트, 서열번호 123 및 서열번호 124로 표시되는 염기서열로 이루어진 VISFATIN검출용 프라이머 세트, 서열번호 125 및 서열번호 126로 표시되는 염기서열로 이루어진 NPAS2검출용 프라이머 세트, 서열번호 127 및 서열번호 128로 표시되는 염기서열로 이루어진 PDGFA검출용 프라이머 세트, 서열번호 129 및 서열번호 130로 표시되는 염기서열로 이루어진 PLAT검출용 프라이머 세트, 서열번호 131 및 서열번호 132로 표시되는 염기서열로 이루어진 PLAU검출용 프라이머 세트, 서열번호 133 및 서열번호 134로 표시되는 염기서열로 이루어진 PLAUR검출용 프라이머 세트, 서열번호 135 및 서열번호 136로 표시되는 염기서열로 이루어진 PLG검출용 프라이머 세트, 서열번호 137 및 서열번호 138로 표시되는 염기서열로 이루어진 PTEN검출용 프라이머 세트, 서열번호 139 및 서열번호 140로 표시되는 염기서열로 이루어진 PTGS2검출용 프라이머 세트, 서열번호 141 및 서열번호 142로 표시되는 염기서열로 이루어진 PTX3검출용 프라이머 세트, 서열번호 143 및 서열번호 144로 표시되는 염기서열로 이루어진 RAC1검출용 프라이머 세트, 서열번호 145 및 서열번호 146로 표시되는 염기서열로 이루어진 RHOA검출용 프라이머 세트, 서열번호 147 및 서열번호 148로 표시되는 염기서열로 이루어진 SERPINB2검출용 프라이머 세트, 서열번호 149 및 서열번호 150로 표시되는 염기서열로 이루어진 SERPINE1검출용 프라이머 세트, 서열번호 151 및 서열번호 152로 표시되는 염기서열로 이루어진 SERPINE2검출용 프라이머 세트, 서열번호 153 및 서열번호 154로 표시되는 염기서열로 이루어진 SLC20A1검출용 프라이머 세트, 서열번호 155 및 서열번호 156로 표시되는 염기서열로 이루어진 SLIT2검출용 프라이머 세트, 서열번호 157 및 서열번호 158로 표시되는 염기서열로 이루어진 SMURF2검출용 프라이머 세트, 서열번호 159 및 서열번호 160로 표시되는 염기서열로 이루어진 STAT3검출용 프라이머 세트, 서열번호 161 및 서열번호 162로 표시되는 염기서열로 이루어진 STC1검출용 프라이머 세트, 서열번호 163 및 서열번호 164로 표시되는 염기서열로 이루어진 SDC4검출용 프라이머 세트, 서열번호 165 및 서열번호 166로 표시되는 염기서열로 이루어진 TAGLN검출용 프라이머 세트, 서열번호 167 및 서열번호 168로 표시되는 염기서열로 이루어진 TFPI2검출용 프라이머 세트, 서열번호 169 및 서열번호 170로 표시되는 염기서열로 이루어진 TGFB1검출용 프라이머 세트, 서열번호 171 및 서열번호 172로 표시되는 염기서열로 이루어진 TGFBR3검출용 프라이머 세트, 서열번호 173 및 서열번호 174로 표시되는 염기서열로 이루어진 TIMP1검출용 프라이머 세트, 서열번호 175 및 서열번호 176로 표시되는 염기서열로 이루어진 TMEM158검출용 프라이머 세트, 서열번호 177 및 서열번호 178로 표시되는 염기서열로 이루어진 TNFAIP6검출용 프라이머 세트, 서열번호 179 및 서열번호 180로 표시되는 염기서열로 이루어진 VEGFA검출용 프라이머 세트, 서열번호 181 및 서열번호 182로 표시되는 염기서열로 이루어진 WNT5A검출용 프라이머 세트, 또는, 서열번호 183 및 서열번호 184로 표시되는 염기서열로 이루어진 GAPDH 검출용 프라이머 세트일 수 있으나 이에 제한되지 않는다.
본 발명에서 사용되는 용어, "프로브"는 특정 폴리뉴클레오티드 서열에 혼성화될 수 있는데 옥시리보뉴클레오티드 및/또는 리보뉴클레오티드를 포함하는 자연 또는 변형된 단량체(monomer) 또는 결합을 갖는 선형의 올리고머(oligomer)를 의미한다. 예를 들어, 상기 프로브는 혼성화의 효율을 높일 수 있도록 단일가닥일 수 있다. 상기 프로브는 주형이 되는 폴리뉴클레오티드 서열에 완전하게 상보적인 서열일 수 있으나, 특이적 혼성화를 방해하지 않는 범위 내에서 실질적으로 상보적인 서열일 수도 있고, 방사성 동위원소나 효소 등을 표지하여 mRNA의 존재 유무를 확인할 수 있으며, 공지된 방법으로 디자인하고 변형시켜 사용할 수 있다.
본 발명에 있어서, 상기 프로브 세트는 형광 표지 물질을 갖는 표시 프로브 세트일 수 있으나, 이에 제한되지 않으며, 상기 표지물질은, 특별히 제한되지 않고, 예를 들면, 상기 표지 프로브가 단독인지, 하이브리드를 형성하고 있는지에 따라, 시그널을 발하는 것이 바람직하다. 상기 시그널의 종류는, 특별히 제한되지 않고, 예를 들면, 형광, 정색 등을 들 수 있다. 상기 정색은, 예를 들면, 발색이어도 되며, 변색이어도 된다. 상기 시그널이 형광의 경우, 시그널 값은, 예를 들면, 형광 강도를 들 수 있다. 상기 시그널이 정색의 경우, 상기 시그널 값은, 예를 들면, 반사율, 흡광도, 투과율 등을 들 수 있다. 상기 시그널은, 예를 들면, 상기 표지물질로부터 직접발해도 되며, 간접적으로 발해도 된다. 상기 표지물질은, 특별히 제한되지 않고, 예를 들면, 형광단 등의 형광표지 물질 등을 들 수 있다. 상기 형광물질은, 예를 들면, 플루오레세인, 인광체, 로다민, 폴리메틴색소 유도체 등을 들 수 있으나, 이에 제한되지 않는다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.
본 발명에서 사용되는 용어, “항체”는 면역학적으로 특정 항원과 반응성을 갖는 면역글로불린 분자를 포함하며, 단클론(monoclonal) 항체 및 다클론(polyclonal) 항체를 모두 포함한다. 또한, 상기 항체는 키메라성 항체(예를 들면, 인간화 뮤린 항체) 및 이종결합항체(예를 들면, 양특이성 항체)와 같은 유전공학에 의해 생산된 형태를 포함한다.
본 발명에서 사용되는 용어, "압타머" 는 특정 물질에 대해 높은 특이성과 친화도를 가지는 단일가닥 DNA(ssDNA) 또는 RNA이다. 기존에 개발되어 있는 항체를 이용한 방법은 생체의 면역 시스템을 이용하여 만들어지기 때문에 비교적 많은 시간이 들고 고비용이라는 점, 단백질이기 때문에 그 안정성이 문제가 되는 경우가 있는 반면, 압타머는 합성에 있어서, 비교적 단순한 방법으로 가능하고 세포, 단백질, 그리고 작은 유기 물질까지도 표적물질이 될 수 있기 때문에, 이를 이용한 새로운 검출 방법들의 개발이 가능하며, 그 특이성 및 안정성이 이미 개발되어 있는 항체에 비해 매우 높다.
본 발명에 사용되는 용어, "리간드"는 유기물질, 단백질, 펩타이드 등을 포함하는 표적물질에 결합하는 물질로 하는 것을 특징으로 하나, 이에 제한되지 않는다.
또한, 본 발명은 상기 상처 치료제 스크리닝용 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공한다.
상기 키트는 예를 들어, 표적핵산을 증폭하기 위한 키트일 수 있다. 증폭은 핵산증폭을 위하여 알려진 방법일 수 있다. 증폭은 예를 들면, DNA 증폭 또는 RNA 증폭일 수 있다. 증폭방법은 열순환(termal cycling)을 필요로 하는 것 또는 등온 (isothermal)에서 수행되는 것일 수 있다. 상기 증폭방법은 폴리머라제 연쇄반응 (polymerase chainreaction: PCR), 핵산서열-기초증폭(nucleic acid sequence-based amplification: NASBA), 리가제연쇄반응(ligase chain reaction: LCR), 가닥치환증폭(strand displacement amplificaton: SDA), 롤링 서클 증폭(rolling circle amplification: RCA) 등을 포함할 수 있다. 증폭 방법은 또한, RNA 증폭 방법을 포함할 수 있다. 예를 들면, 역전사(reverse transcription: RT) 또는 역전사-PCR을 포함할 수 있다. 증폭이란 표적핵산서열 또는 그에 상보적인 서열의 카피수를 증가시키는 것 일 수 있다. "PCR"은 중합효소를 이용하여 표적핵산에 특이적으로 결합하는 프라이머 쌍으로부터 표적핵산을 증폭하는 방법일 수 있다. 또한, 상기 키트는 표적핵산의 증폭에 요구되는 알려진 물질을 더 포함할 수 있다. 예를 들면, 키트는 핵산폴리머라제, 그의 활성에 필요한 버퍼, 보조인자, 및/또는 기질을 더 포함할 수 있다. 상기 핵산폴리머라제는 DNA 폴리머라제, RNA 폴리머라제, 역전사효소(reverse transcriptase) 및 이들의 조합일 수 있다. 역전사(reverse transcription)란 RNA를 주형으로 하여 RNA 서열에 상보적인 DNA 가닥을 합성하는 것 일 수 있다. 상기 핵산폴리머라제는 가닥치환활성을 갖는 것 일 수 있다. 예를 들면, 레트로바이러스, 예를 들면, HIV, MMLV, 및 AMV로부터 유래된 역전사효소 일 수 있다. 상기 핵산폴리머라제는 3'-> 5' 엑소뉴클레아제활성(exonuclease activity)을 갖지 않는 것 일 수 있다. 상기 키트는 역전사 또는 PCR 증폭에 필요한 물질을 포함하는 것 일 수 있으며, 바람직하게는 96-웰 실시간 유전자 중합반응 어레이 키트일 수 있으나, 이에 제한되지 않는다.
또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;
(b) 상기 섬유아세포에서 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c)상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공한다.
본 발명에 있어서, 상기 시료는 섬유아세포에서 발현되는 유전자의 발현량을 측정하기 위하여, 스크리닝에서 사용되는 미지의 물질을 의미하며, 바람직하게는 화합물, 미생물 배양액 또는 추출물, 천연물 추출물, 핵산, 및 펩타이드로 이루어진 군으로부터 선택되는 것일 수 있으며, 상기 핵산은 microRNA, siRNA, shRNA, 안티센스 RNA, 앱타머(aptamer), LNA(locked nucleic acid), PNA(peptide nucleic acid), 및 모폴리노(morpholino)로 이루어진 군으로부터 선택되는 것일 수 있으나, 이에 한정되는 것은 아니다.
본 발명에서 사용되는 용어, “microRNA”란 약 22개의 염기서열로 이루어진 짧은 non-coding RNA를 의미한다. 유전자의 발현 과정에서 전사 후 조절인자(post-transcriptional regulator)로서 기능을 한다고 알려져 있다. 상보적인 염기 서열을 가진 표적(target) mRNA에 상보적으로 결합함으로써 표적 mRNA들을 분해시키거나 단백질로 번역되는 것을 억제한다.
본 발명에서 사용되는 용어, “siRNA(small interfering RNA)”란 특정 mRNA의 절단(cleavage)을 통하여 RNA간섭(RNA interference; RNAi) 현상을 유도할 수 있는 짧은 이중사슬 RNA를 의미한다. 타겟 유전자의 mRNA와 상동인 서열을 가지는 센스 RNA 가닥과 이와 상보적인 서열을 가지는 안티센스 RNA 가닥으로 구성된다. siRNA는 타겟 유전자의 발현을 억제할 수 있기 때문에 효율적인 유전자 넉다운(knock-down) 방법으로서 또는, 유전자치료(gene therapy)의 방법으로 제공된다.
본 발명에서 용어 “shRNA(small hairpin RNA)”란 단일 가닥으로 50-60개로 구성된 뉴클레오타이드를 의미하며, in vivo상에서 스템-루프(stem-loop) 구조를 이루고 있다. 즉, shRNA는 RNA 간섭을 통해 유전자 발현을 억제하기 위한 타이트한 헤어핀 구조를 만드는 RNA 서열이다. 5-10개의 뉴클레오타이드의 루프 부위 양쪽으로 상보적으로 15-30개의 뉴클레오타이드의 긴 RNA가 염기쌍을 이루어 이중가닥의 스템을 형성한다. shRNA는 언제나 발현되도록 하기 위하여 U6 프로모터를 포함하는 벡터를 통해 세포 내로 실시예 1-5와 같이 형질주입되며 대개 딸세포로 전달되어 유전자 발현억제가 유전되도록 한다. shRNA 헤어핀 구조는 세포 내 기작에 의하여 절단되어 siRNA가 된 후 RISC(RNA-induced silencing complex)에 결합한다. 이들 RISC는 mRNA에 결합하여 이를 절단한다. shRNA는 RNA 폴리머레이즈(polymerase)에 의해 전사된다.
본 발명에 있어서, 유전자의 발현량을 측정하는 단계는 상처 치유 관련 유전자의 발현에 의해 생성된 RNA 또는 단백질의 양을 측정할 수 있는 당업계에 공지된 다양한 방법을 통해 실시될 수 있다. 바람직하게 RNA의 발현량은 중합효소연쇄반응(PCR), 마이크로어레이(microarray), 노던 블롯팅(northern blotting) 등을 통해 측정할 수 있고, 단백질의 발현량은 웨스턴 블롯팅(western blotting), 효소면역분석법(ELISA), 면역침강법(immunoprecipitation), 면역화학염색법(immunohistochemistry), 또는 면역형광염색법(immunofluorescence) 등을 통해 측정할 수 있으며, 당업자에 의해 매우 간단하고 용이하게 실시될 수 있으나, 이것으로 제한되는 것은 아니다.
또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공한다.
본 발명에 있어서, 상기 단백질은 바람직하게는 VISFATIN또는 STC1 단백질일 수 있으나, 이에 제한되지 않는다. 또한, 상기 상처 치료용 약학적 조성물은 ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시킬 수 있으나 이에 제한되지 않는다.
본 발명에서 사용되는 용어, “치료”란 상처 발병 후에 본 발명에 따른 약학적 조성물의 투여에 의해 상처에 대한 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.
이에, 약학적 조성물로 제조하기 위하여 통상적으로 사용하는 적절한 담체, 부형제, 및 희석제를 더 포함할 수 있다. 또한 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제, 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있다.
상기 조성물에 포함될 수 있는 담체, 부형제, 및 희석제로는 락토오스, 덱스트로오스, 수크로오스, 소르비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐 피롤리돈, 물, 메틸히드록시 벤조에이트, 프로필히드록시 벤조에이트, 탈크, 마그네슘 스테아레이트, 및 광물유 등이 있다. 상기 조성물을 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다.
본 발명에 따른 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에 있어서, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효용량 수준은 환자의 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출 비율, 치료기간, 동시 사용되는 약물을 포함한 요소, 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.
본 발명에 따른 약학적 조성물은 치료효과를 증진시키기 위하여, 바람직하게는 병용되는 약물과 동시에(simultaneous), 별도로(separate), 또는 순차적(sequential)으로 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 상기한 요소들을 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 당업자에 의해 용이하게 결정될 수 있다. 구체적으로, 본 발명에 따른 약학적 조성물의 유효량은 환자의 연령, 성별, 상태, 체중, 체내에서 활성 성분의 흡수도, 불활성율 및 배설속도, 질병종류, 병용되는 약물에 따라 달라질 수 있다.
본 발명의 약학적 조성물은 개체에게 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구 투여, 비강 내 투여, 경기관지 투여, 동맥 주사, 정맥 주사, 피하 주사, 근육 주사, 또는 복강 내 주사에 의해 투여될 수 있다. 일일 투여량은 하루 일회 내지 수회 나누어 투여하는 것이 바람직하나, 이에 제한되는 아니다.
본 발명의 약학적 조성물은 치료할 질환, 투여 경로, 환자의 연령, 성별, 체중, 및 질환의 중등도 등의 여러 관련 인자와 함께, 활성성분인 약물의 종류에 따라 결정된다.
본 발명의 다른 양태로서, 본 발명은 상기 약학적 조성물을 개체에 투여하는 단계를 포함하는 상처 치료 방법을 제공한다. 본 발명에서 "개체"란 질병의 치료를 필요로 하는 대상을 의미하고, 보다 구체적으로는, 인간 또는 비-인간인 영장류, 생쥐(mouse), 개, 고양이, 말, 및 소 등의 포유류를 의미한다.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 하기 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.
[실시예]
실시예 1. 물질 및 방법
1-1. 피부 섬유아세포 배양
인간 피부 섬유아세포를 F12K와 DMEM 배지에 3:1로 섞고, 10% FBS, 100U/ml 페니실린(penicillin), 0.1mg/ml 스트렙토미신(streptomycin)을 첨가한 배지를 이용하여 배양하였다.
1-2. cDNA 마이크로어레이를 위한 섬유아세포에 표피생장인자 처리 및 mRNA 분리
피부 섬유아세포는 6-웰 플레이트에서 2×105 cells/well씩 24시간 배양되었다. 24시간 배양 후 10% FBS를 첨가하지 않은 배지를 사용하여 배양하였다. 음성대조군으로 배지만 첨가된 것을 사용하였고, 실험군에는 1, 10, 50ng/mL 농도로 12시간 배양하였다. 배양된 피부 섬유아세포로부터 RNA를 분리하였다.
1-3. cDNA 마이크로어레이 실시 및 실시간 정량 유전자 중합반응 어레이 (Real-time quantitative PCR array) 키트 제작
분리된 총 500ng의 RNA(GeneChip WT PLUS reagent kit, Carlsbad, California, USA)를 사용하여 단편 DNA(ss-DNA)을 합성하였다. 총 3.5μg의 단편 DNA를 cDNA 마이크로어레이를 실시하였다. Affymetrix 기본 분석 설정 및 전역 배율을 사용하여 테이터를 분석하였다. 유전자 발현 폴드 변화는 배지만을 첨가한 대조군에 비해 200% 이상 증가한 2배 상향 조절 유전자와 50% 미만인 2배 미만의 하향 조절 유전자를 존재해야 한다는 요건을 포함한다. 분석된 유전자 중 92개의 유전자를 선별 및 발굴하였다. 발굴된 92개의 유전자를 이용하여 실시간 정량 유전자 중합반응 어레이키트를 제작하기 위해 프라이머를 디자인하였다. 96-웰에 디자인된 프라이머를 첨가하고 합성된 cDNA, 급속 사이버그린 텍폴리머레이즈를 첨가하여 실시간 정량 유전자 중합반응 어레이 키트를 제작하였다.
1-4. 피부 섬유아세포 증식 측정
96-웰 플레이트에 2×104 cells/well씩, 24 시간 동안 배양한 후, 16시간 동안 10% FBS (혈청)이 첨가하지 않은 배지에 배양하였다. 발굴된 92개의 유전자중 2개의 유전자를 선택하고 단백질을 확보하였다. 확보된 단백질을 피부 섬유아세포에 처리하였다. 음성대조군으로 배지만 첨가된 것, 양성대조군으로 표피생장인자 EGF 처리군이 사용되었으며, 실험군에는 1, 10, 50ng/mL의 농도로 VISFATIN 또는 STC1단백질이 24 시간 동안 처리되었다. 피부 섬유아세포의 증식 정도는 DNA에 표지된 BrdU 양이 증가하는 것을 플레이트 리더로 흡광도를 측정하여 확인하였다.
1-5. 피부섬유아세포 이동능 측정
12-웰 플레이트에 1×105 cells/well씩 24 시간 동안 배양한 후, 16시간 동안 10% FBS (혈청)이 첨가하지 않은 배지에 배양하였다. VISFATIN이나 STC1 단백질을 처리하기 전에 200μL의 팁을 이용하여 각각의 웰을 스크래치를 하였다. 확보된 단백질을 피부 섬유아세포에 처리하였다. 음성대조군으로 배지만 첨가된 것, 양성대조군으로 표피생장인자 EGF 처리군이 사용되었으며, 실험군에는 1, 10, 50ng/mL의 농도로 VISFATIN 또는 STC1 단백질이 24 시간 동안 처리되었다. VISFATIN과STC1 단백질에 의해 증가된 피부 섬유아세포의 이동능력은 로다민 팔로이딘(적색, Rhodamine phalloidin)으로 표지 되었으며, 현미경으로 관찰되었으며 사진을 찍어 스크래치된 부분의 면적을 분석해서 이동능력을 확인하였다.
1-6. 급성창상 마우스 모델에서 상처 치유능력 측정
Pluronic ® 127을 saline에 22% (w/v)가 되도록 4℃에서 밤새도록 교반하여 녹인다. 이렇게 해서 하이드로젤을 만들어 4℃에서 보관한다. 하이드로젤은 실온에서 굳고 4℃이하에서는 젤의 형태를 유지하게 된다. VISFATIN 과 STC1 단백질을1μg/상처/25μL가 되도록 하이드로젤 형태로 준비하고 하이드로젤의 최종농도는 20%가 되도록 한다. 급성창상 마우스 모델에서 상처 치유능력을 측정하기 위해서 마우스 등 부분의 털을 제거한다. 마우스를 호흡마취를 통해 마취를 시킨 다음, 곧 바로 사진을 찍고 VISFATIN 단백질-하이드로젤 또는 STC1 단백질-하이드로젤 25μL를 상처에 처리한다. VISFATIN 단백질- 또는 STC1 단백질-하이드로젤은 1회/1일, 5일 동안 처리하도록 하고, 10일까지 관찰하고 사진을 찍어 확인한다. 이미지 J(Image J) 소프트웨어를 이용하여 상처 치료 정도를 분석하였다.
1-7. 급성창상 마우스 조직 분석
VISFATIN 단백질- 또는 STC1 단백질-하이드로젤을 처리한 후 6일 후에 마우스 피부 조직을 획득한다. 획득한 창상 조직은 고정, 파라핀고정, 조직 박편, 탈파라핀 과정을 거치고 헤마톡실린/에오신(H&E) 염색과 형광항체1/100 비율로 희석하여 실온에서 1시간동안 형광조직염색을 실시하였다. 염색된 조직 슬라이드는 OlympusIX 71를 이용하여 이미지화하였다. 이미지화한 조직은 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다.
1-8. 통계적 분석
대조군과 실험군의 차이는 paired Student's t-test에 의해서 평가되었으며, P-values<0.05 인 경우 유의한 차이로 고려되었다.
실시예 2. cDNA 마이크로어레이를 이용한 상처치료에 관련된 유전자의 발굴 및 실시간 정량 유전자 중합반응 어레이 키트 제작
피부 섬유아세포는 6-웰 플레이트에서 2×105 cells/well씩, 24 시간 배양되었다. 24시간 배양 후 10% 혈청을 첨가하지 않은 배지를 사용하여 배양한다. 음성대조군으로 배지만 첨가된 것, 실험군에는 표피생성인자인 EGF를 1, 10, 50 ng/mL 농도로 12시간 배양하였다. 배양된 피부 섬유아세포로부터 RNA를 분리 한다.
분리된 총 500ng의 RNA(GeneChip WT PLUS reagent kit, Carlsbad, California, USA)를 사용하여 단편 DNA(ss-DNA)을 합성하였다. 총 3.5μg의 단편 DNA를 Affymetrix Human Gene ST 2.0 array에 Affymetrix hybridization system을 이용하여 혼성화한다. Fluidics 450을 이용하여 array를 세척하고 염색을 진행하였다. Affymetri scannder 3000 7G를 이용하여 결과를 획득하고 스캐닝을 통하여 얻어진 스팟의 신호강도를 수치화 테이터를 사용하여 RMA(Robust multi-array average) 평균화를 한다. 분석된 유전자 중 92개의 유전자를 선별 및 발굴하였다(도 1 참조). 발굴된 92개의 유전자를 이용하여 실시간 정량 유전자 중합반응 어레이키트를 제작하기 위해 프라이머를 하기 표1에 나타난 바와 같이 디자인하였다.
Number | Primer name | Forward sequence (5' --> 3') | Reverse sequence (5' --> 3') |
1 | hACTA2 | TAGCACCCAGCACCATGAAG | CTGCTGGAAGGTGGACAGAG |
2 | hBMPER | AAGCATGGTGCTGTGTACGA | CAAGTTTGCTGGACAGTGGC |
3 | hCCL2 | ATCAATGCCCCAGTCACCTG | TCTCCTTGGCCACAATGGTC |
4 | hCH25H | ACATCTGGCTTTCCGTGGAG | ACGGAGCGAAGTTGCAGTTA |
5 | hCOL1A1 | CATGACCGAGACGTGTGGAA | GGCAGTTCTTGGTCTCGTCA |
6 | hCOL1A2 | CTGCTGGAAGTCGTGGTGAT | ACGAAGCCCTTCTTTCCCAG |
7 | hCOL3A1 | TGTTCCAGGAGCTAAAGGCG | CTCCTGGGATGCCATTTGGT |
8 | hCOL4A1 | TTTTGTGATGCACACCAGCG | AGTAATTGCAGGTCCCACGG |
9 | hCOL5A1 | AGACATGGGCATCAAGGGTG | CCGAGTTTTCCCTTCTCCCC |
10 | hCOL5A2 | GAGAACAAGGACCTCCAGGC | TCTAGGTCCTAACGGGCCAA |
11 | hCSF3 | CGGCCTTTTCCTCTACCAGG | GGCCATTCCCAGTTCTTCCA |
12 | hCTGF | GTTTGGCCCAGACCCAACTA | GGCTCTGCTTCTCTAGCCTG |
13 | hCTNNB1 | ATGATGGTCTGCCAAGTGGG | GGCCATCTCTGCTTCTTGGT |
14 | hCTSK | GGGGGACATGACCAGTGAAG | CAGAGTCTGGGGCTCTACCT |
15 | hCXCL1 | TGCAGGGAATTCACCCCAAG | AGCTTTCCGCCCATTCTTGA |
16 | hCXCL5 | TGTGTTGAGAGAGCTGCGTT | CTTCCACCTTGGAGCACTGT |
17 | hCXCL6 | CTGTCTCTGCTGTGCTGACA | CACTTCCACCTTGGAGCACT |
18 | hDUSP6 | CGGAAATGGCGATCAGCAAG | TGTGCGACGACTCGTATAGC |
19 | hEGFR | TTGCCGCAAAGTGTGTAACG | GAGATCGCCACTGATGGAGG |
20 | hEGR1 | GCTGGTGGAGACCAGTTACC | CTGACCAAGCTGAAGAGGGG |
21 | hEMP1 | ATGCCAGTGAAGATGCCCTC | GGTGAAGAGCTGGAACACGA |
22 | hENO1 | CTGCCTCCTGCTCAAAGTCA | AACCAGGTCAGCGATGAAGG |
23 | hERRFI1 | GACAGGCCTCCCAAAGTACC | ACTTGGGATCAGGGGCAAAG |
24 | hESM1 | ACTTGCTACCGCACAGTCTC | CTGCAATCCATCCCGAAGGT |
25 | hFGA | CTGCCTGGTCCTAAGTGTGG | GCAGAAGGGCCAGTCTGAAT |
26 | hFGF10 | GTGCGGAGCTACAATCACCT | ACGGGCAGTTCTCCTTCTTG |
27 | hFGF2 | AAAAACGGGGGCTTCTTCCT | AGCCAGGTAACGGTTAGCAC |
28 | hFGF7 | TGGATCCTGCCAACTTTGCT | TTCTTGTGTGTCGCTCAGGG |
29 | hFOSL1 | GCGGAGACTGACAAACTGGA | CTTGGCTCCTTCCGGGATTT |
30 | hFST | TGCTCTGCCAGTTCATGGAG | GCACTCCTCCTTGCTCAGTT |
31 | hHAS2 | TGACAGGCATCTCACGAACC | GGGTCTGCTGGTTTAGCCAT |
32 | hHBEGF | AGTCCGTGACTTGCAAGAGG | CCTCTTCTTCCCTAGCCCCT |
33 | hHGF | ACCCTGGTGTTTCACAAGCA | TCCCAGCGCTGACAAATCTT |
34 | hHMGA2 | GCCCTCTCCTAAGAGACCCA | CTGCCTCTTGGCCGTTTTTC |
35 | hICAM1 | CCAGGAGACACTGCAGACAG | CTTCACTGTCACCTCGGTCC |
36 | hIER3 | CCTGATGGCTGAAGAGGGTG | ATTAAAGGGCTCGAGGACGG |
37 | hIL-13RA2 | ATGCTGGGAAGGTGAAGACC | GGCTTACGCAAAAGCAGACC |
38 | hIL-33 | TCAGGTGACGGTGTTGATGG | GGAGCTCCACAGAGTGTTCC |
39 | hIL1B | CCACCTCCAGGGACAGGATA | AACACGCAGGACAGGTACAG |
40 | hIL6 | AGTGAGGAACAAGCCAGAGC | ATTTGTGGTTGGGTCAGGGG |
41 | hIL6ST | ACACAGCAGTGGTATTGGGG | ACTGGACAGTGCTCGAAGTG |
42 | hIL7R | CCCTAGACTGCAGGGAGAGT | GGAGAGAAAATGGAGGGGGC |
43 | hIL8 | CTCCAAACCTTTCCACCCCA | TTCCTTGGGGTCCAGACAGA |
44 | hITGA1 | GGCAGCACAATTCATGCACA | TGATCATCTTCCAGCGGAGC |
45 | hITGA2 | CACAAAGACACAGGTGGGGT | TGGGATGTCTGGGATGTTGC |
46 | hITGA3 | GGACATGTGGCTTGGAGTGA | GCTGGTCTTCTGACCCTGAC |
47 | hITGA4 | TGGAGCTTCTGTCTGTGCTG | CTCCCGAGCCAGAGTTGATG |
48 | hITGA5 | ACATCTGTGTGCCTGACCTG | CTCACCCACATTCTGGGCAT |
49 | hITGAV | TCCGATTCCAAACTGGGAGC | AAGGCCACTGAAGATGGAGC |
50 | hITGB1 | GTCGTGTGTGTGAGTGCAAC | AGACACCACACTCGCAGATG |
51 | hITGB3 | GCCCTGCTCATCTGGAAACT | TTGGTGAAGGTAGACGTGGC |
52 | hITGB5 | CACCCAAAATGTGCCTGGTG | TCAGGACATGGAAGCTGCTG |
53 | hKRTAP1-5 | CAGACAGTCGTGTGGAGGG | GCAGGACTGTCCACAGTAGG |
54 | hLPXN | TGACTGAGATGCAGGCCAAG | AGGTCCTGCAATTCCTGCTC |
55 | hMAPK1 | ACCTACTGCCAGAGAACCCT | TCGATGGTTGGTGCTCGAAT |
56 | hMAPK3 | ACCACATTCTGGGCATCCTG | CTTGGTCTTGGAGGGCAGAG |
57 | hMCL1 | GAGGAGGAGGAGGACGAGTT | CTGCCCATTGGCTTTGTGTC |
58 | hMIF | CAGAACCGCTCCTACAGCAA | AAGGTGGAGTTGTTCCAGCC |
59 | hMMP1 | AGTGGCCCAGTGGTTGAAAA | CCACATCAGGCACTCCACAT |
60 | hMMP2 | CCCTGTGTCTTCCCCTTCAC | ATCGTAGTTGGCTGTGGTCG |
61 | hMMP3 | CACAGACCTGACTCGGTTCC | AGGTTCTGGAGGGACAGGTT |
62 | hVISFATIN | TCGGTTCTGGTGGAGGTTTG | TTGGGATCAGCAACTGGGTC |
63 | hNPAS2 | ATCCTGCAGGCCAATATCCG | CTGCTGCAGGAACATCTGGA |
64 | hPDGFA | GGCCAAGGTGGAATACGTCA | ATCCGGATTCAGGCTTGTGG |
65 | hPLAT | TACAGCCAGCCTCAGTTTCG | GAGCTGATGAGTATGCCCCC |
66 | hPLAU | CCAAAATGCTGTGTGCTGCT | TTGTCCTTCAGGGCACATCC |
67 | hPLAUR | GGCTTGAAGATCACCAGCCT | TGCATTCGAGGTAACGGCTT |
68 | hPLG | CTACCCAAATGCTGGCCTGA | ACTCGCTTCTGTTCCTGAGC |
69 | hPTEN | TGTGGTCTGCCAGCTAAAGG | ACACACAGGTAACGGCTGAG |
70 | hPTGS2 | GTTCCACCCGCAGTACAGAA | AGGGCTTCAGCATAAAGCGT |
71 | hPTX3 | CCTGCATTTGGGTCAAAGCC | CTCCACCCACCACAAACACT |
72 | hRAC1 | CATCACCTATCCGCAGGGTC | TCGGATCGCTTCGTCAAACA |
73 | hRHOA | GGTGATGGAGCCTGTGGAAA | TGTGTCCCACAAAGCCAACT |
74 | hSERPINB2 | GCTGGCACAGGAGGTGTTAT | AGGGTGAGGAAAATCTGCCG |
75 | hSERPINE 1 | GGGCCATGGAACAAGGATGA | CCGGAACAGCCTGAAGAAGT |
76 | hSERPINE2 | AAGAAACGCACTTTCGTGGC | CCGTGGTAGGGCAGTTCAAT |
77 | hSLC20A1 | GCAACTCGTGGCTTCGTTTT | GACCACTTGACACCCTCCTG |
78 | hSLIT2 | AAGCTTCAGACCATCGCCAA | AGCCACTTGAGATGGCAGTC |
79 | hSMURF2 | AGATCCTCGGCTGTCTGCTA | CTGAACCAGGTCTCGCTTGT |
80 | hSTAT3 | CTGTGGGAAGAATCACGCCT | ACATCCTGAAGGTGCTGCTC |
81 | hSTC1 | TTGCTGAGGTGCAGGAAGAG | CAGGCTTCGGACAAGTCTGT |
82 | hSDC4 | CCCTCCACTTGGAAGGACAC | CAGGACTACAGCCTCTCCCT |
83 | hTAGLN | AGGTCTGGCTGAAGAATGGC | CACCTGCTCCATCTGCTTGA |
84 | hTFPI2 | CTGTCTCCTGCCCCTAGACT | AAATTGTTGGCGTTGCCCTC |
85 | hTGFB1 | TGGTGGAAACCCACAACGAA | GAGCAACACGGGTTCAGGTA |
86 | hTGFBR3 | CCTCAGTCCACATCCACCAC | CCACAGAACCCTCAGACACC |
87 | hTIMP1 | GGGGCTTCACCAAGACCTAC | GGAAGCCCTTTTCAGAGCCT |
88 | hTMEM158 | CTGCTGCCTAGACTTCAGCC | CTCCACACCACGATGACCAG |
89 | hTNFAIP6 | AGCACGGTCTGGCAAATACA | ATCCATCCAGCAGCACAGAC |
90 | hVEGFA | CTTGCCTTGCTGCTCTACCT | GCAGTAGCTGCGCTGATAGA |
91 | hWNT5A | CGCGAAGACAGGCATCAAAG | ATCTGCATCACCCTGCCAAA |
92 | hGAPDH | TCCTGCACCACCAACTGTTT | GTCCACTGTCTTCTGGGTGG |
실시예 3. 발굴된 92개의 유전자 중 2개의 유전자인 VISFATIN과 STC1의 세포증식 효과 확인
cDNA 마이크로어레이를 통해 발굴된 92개의 유전자 중 2개의 유전자인 VISFATIN과 STC1을 선택해 단백질을 확보하여 피부 섬유아세포의 세포 증식 효과가 있는지를 BrdU 어세이를 통해 확인하였다. 배지만 첨가한 음성대조군, VISFATIN 또는 STC1을 1, 10, 50, 100ng/mL의 농도로 24 시간 처리한 실험군, 표피생장인자인 EGF를 1, 10, 50, 100 ng/mL의 농도로 24 시간 처리한 양성대조군의 피부 섬유아세포의 세포 증식을 확인한 결과, 도 2a 및 2b에 나타난 바와 같이, 양성대조군인 표피생장인자를 처리한 세포 증식 결과와 VISFATIN 단백질과 STC1 단백질을 처리한 실험군의 세포 증식 효과가 유의하게 나타남을 확인하였다(3회 반복시험 결과, *P<0.01, 배지만 첨가한 음성대조군에 대하여). 즉, cDNA 마이크로어레이를 통해 발굴한 유전자인 VISFATIN 단백질과 STC1 단백질이 상처치료에 중요한 역할을 하는 세포 증식을 증가시킴을 확인할 수 있었다.
실시예 4. VISFATIN 단백질과 STC1 단백질의 세포 이동능력 증가를 확인
상처 치료에 중요한 단계 중의 하나인 세포 이동능을 VISFATIN 단백질과 STC1 단백질이 영향을 주는지 확인하기 위해서 스크래치 어세이를 실시하였다. 먼저, 12-웰 플레이트에 배양된 피부 섬유세포를 200μL 팀을 이용하여 균일하게 스크래치를 만든 후, 피부 섬유아세포를 배지만 처리한 음성대조군, VISFATIN 단백질 또는 STC1 단백질을 처리한 실험군, 표피생장인자를 처리한 양성실험군을 각각 1, 10, 50 ng/mL 처리하고 24시간 배양하였다. 세포는 4% paraformaldehyde로 고정시키고 난 후, 로다민 팔로이딘(Rhodamine phalliodin, 적색)을 PBS에 1/200으로 희석하여 실온에서 1시간 동안 염색하였다. 로다민 팔로이딘으로 염색된 세포는 OlympusIX 71를 이용하여 이미지화하였다. 이미지화한 조직은 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다. 결과적으로 도 3a 및 3b에 나타난 바와 같이, VISFATIN 단백질 또는 STC1 단백질을 처리한 피부 섬유아세포의 세포 이동이 아무것도 처리하지 않은 세포에 비해 확연하게 증가함을 확인하였다 (3회 반복시험 결과, *P<0.01, **P<0.05, 미처리군에 대하여).
실시예 5.VISFATIN 단백질과 STC1 단백질의 마우스 급성창상에 대한 치유능력을 향상을 확인
마우스 동물 급성창상 모델에서 VISFATIN 단백질과 STC1 단백질의 상처치유 능력을 측정하였다. 1μg/25μL의 VISFATIN 단백질- 또는 STC1 단백질-하이드로젤을 마우스 급성창상에 1회/1일, 5일간 처리하였다. 음성대조군은 25μL의 saline-하이드로젤, 양성대조군은 25μL의 표피생장인자 EGF를 1회/1일, 5일간 처리하였다. 창상의 치유 변화는 매일 사진을 찍어 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다. 그 결과, 도 4a 및 4b에 나타난 바와 같이, VISFATIN 단백질과 STC1 단백질을 처리한 실험군은 표피생장인자를 처리한 양성대조군과 유사하게 급성창상을 치유함을 확인할 수 있었다.
실시예 6. VISFATIN단백질에 의해 유도된 VEGF의 발현 증가가 상처치유 향상을 확인
VISFATIN 단백질과 STC1 단백질에 유도된 마우스 급성창상 모델에서 상처 치유를 향상시키는 원인을 확인하게 위해 saline-하이드로젤(음성대조군), 1μg/25μL의 VISFATIN 단백질-하이드로젤(실험군), 또는, 1μg/25μL의 표피생장인자 EGF(양성대조군)을 6일간 처리한 마우스 창상 조직을 획득하여, 조직 염색을 실시하였다. 조직염색으로는 헤마톡실린&에오신(H&E) 염색을 실시하였으며, 같은 조직의 같은 부위를 1차로 혈관내피성장인자(Vascular endothelial growth factor, VEGF) 항체로 반응시키고 2차로 마우스-형광 Alexa 488 항체로 반응시켜 조직 내 VEGF의 발현을 측정하였다. 그 결과, 도 5에 나타난 바와 같이, 혈관내피성장인자인 VEGF가 VISFATIN 단백질-하이드로젤을 처리한 마우스 창상조직에서 음성대조군에 비해 확연하게 증가함을 확인하였다. 또한, VEGF 발현이 양성대조군을 처리한 결과와 유사하게 증가함을 확인할 수 있었다(3회 반복시험 결과, *P<0.05, 미처리군에 대하여). 더불어, VEGF 발현증가의 분자적 메커니즘을 확인하기 위해 pERK와 pJNK의 1차 항체와 2차 마우스-형광 Alexa 488 항체로 조직을 형광 염색하였다. 그 결과, 도 6에 나타난 바와 같이, pERK와 pJNK의 활성화가 VISFATIN단백질-하이드로젤을 처리한 마우스 창상조직에서 음성대조군에 비해 확연하게 증가함을 확인하였다. 또한, ERK와 JNK의 활성화가 양성대조군을 처리한 결과와 유사하게 증가함을 확인할 수 있었다(3회 반복시험 결과, *P<0.05, 미처리군에 대하여). 즉, VISFATIN 단백질이 ERK와 JNK의 활성화를 유도해서 VEGF의 발현을 증가시키고 증가된 VEGF로 인해 상처 치유를 향상시킴을 확인 할 수 있었다.
전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다름 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 아닌 것으로 이해해야 한다.
<110> Korea University Industry and Academy Cooperation Foundation
<120> Composition for the screening of wound healing agent and
screening method for the same
<130> MP18-299
<160> 276
<170> KoPatentIn 3.0
<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hACTA2 F
<400> 1
tagcacccag caccatgaag 20
<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hACTA2 R
<400> 2
ctgctggaag gtggacagag 20
<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hBMPER F
<400> 3
aagcatggtg ctgtgtacga 20
<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hBMPER R
<400> 4
caagtttgct ggacagtggc 20
<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCCL2 F
<400> 5
atcaatgccc cagtcacctg 20
<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCCL2 R
<400> 6
tctccttggc cacaatggtc 20
<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCH25H F
<400> 7
acatctggct ttccgtggag 20
<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCH25H R
<400> 8
acggagcgaa gttgcagtta 20
<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL1A1 F
<400> 9
catgaccgag acgtgtggaa 20
<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL1A1 R
<400> 10
ggcagttctt ggtctcgtca 20
<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL1A2 F
<400> 11
ctgctggaag tcgtggtgat 20
<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL1A2 R
<400> 12
acgaagccct tctttcccag 20
<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL3A1 F
<400> 13
tgttccagga gctaaaggcg 20
<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL3A1 R
<400> 14
ctcctgggat gccatttggt 20
<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL4A1 F
<400> 15
ttttgtgatg cacaccagcg 20
<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL4A1 R
<400> 16
agtaattgca ggtcccacgg 20
<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL5A1 F
<400> 17
agacatgggc atcaagggtg 20
<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL5A1 R
<400> 18
ccgagttttc ccttctcccc 20
<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL5A2 F
<400> 19
gagaacaagg acctccaggc 20
<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCOL5A2 R
<400> 20
tctaggtcct aacgggccaa 20
<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCSF3 F
<400> 21
cggccttttc ctctaccagg 20
<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCSF3 R
<400> 22
ggccattccc agttcttcca 20
<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTGF F
<400> 23
gtttggccca gacccaacta 20
<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTGF R
<400> 24
ggctctgctt ctctagcctg 20
<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTNNB1 F
<400> 25
atgatggtct gccaagtggg 20
<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTNNB1 R
<400> 26
ggccatctct gcttcttggt 20
<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTSK F
<400> 27
gggggacatg accagtgaag 20
<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCTSK R
<400> 28
cagagtctgg ggctctacct 20
<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL1 F
<400> 29
tgcagggaat tcaccccaag 20
<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL1 R
<400> 30
agctttccgc ccattcttga 20
<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL5 F
<400> 31
tgtgttgaga gagctgcgtt 20
<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL5 R
<400> 32
cttccacctt ggagcactgt 20
<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL6 F
<400> 33
ctgtctctgc tgtgctgaca 20
<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hCXCL6 R
<400> 34
cacttccacc ttggagcact 20
<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hDUSP6 F
<400> 35
cggaaatggc gatcagcaag 20
<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hDUSP6 R
<400> 36
tgtgcgacga ctcgtatagc 20
<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEGFR F
<400> 37
ttgccgcaaa gtgtgtaacg 20
<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEGFR R
<400> 38
gagatcgcca ctgatggagg 20
<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEGR1 F
<400> 39
gctggtggag accagttacc 20
<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEGR1 R
<400> 40
ctgaccaagc tgaagagggg 20
<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEMP1 F
<400> 41
atgccagtga agatgccctc 20
<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hEMP1 R
<400> 42
ggtgaagagc tggaacacga 20
<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hENO1 F
<400> 43
ctgcctcctg ctcaaagtca 20
<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hENO1 R
<400> 44
aaccaggtca gcgatgaagg 20
<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hERRFI1 F
<400> 45
gacaggcctc ccaaagtacc 20
<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hERRFI1 R
<400> 46
acttgggatc aggggcaaag 20
<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hESM1 F
<400> 47
acttgctacc gcacagtctc 20
<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hESM1 R
<400> 48
ctgcaatcca tcccgaaggt 20
<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGA F
<400> 49
ctgcctggtc ctaagtgtgg 20
<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGA R
<400> 50
gcagaagggc cagtctgaat 20
<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF10 F
<400> 51
gtgcggagct acaatcacct 20
<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF10 R
<400> 52
acgggcagtt ctccttcttg 20
<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF2 F
<400> 53
aaaaacgggg gcttcttcct 20
<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF2 R
<400> 54
agccaggtaa cggttagcac 20
<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF7 F
<400> 55
tggatcctgc caactttgct 20
<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFGF7 R
<400> 56
ttcttgtgtg tcgctcaggg 20
<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFOSL1 F
<400> 57
gcggagactg acaaactgga 20
<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFOSL1 R
<400> 58
cttggctcct tccgggattt 20
<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFST F
<400> 59
tgctctgcca gttcatggag 20
<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hFST R
<400> 60
gcactcctcc ttgctcagtt 20
<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHAS2 F
<400> 61
tgacaggcat ctcacgaacc 20
<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHAS2 R
<400> 62
gggtctgctg gtttagccat 20
<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHBEGF F
<400> 63
agtccgtgac ttgcaagagg 20
<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHBEGF R
<400> 64
cctcttcttc cctagcccct 20
<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHGF F
<400> 65
accctggtgt ttcacaagca 20
<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHGF R
<400> 66
tcccagcgct gacaaatctt 20
<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHMGA2 F
<400> 67
gccctctcct aagagaccca 20
<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hHMGA2 R
<400> 68
ctgcctcttg gccgtttttc 20
<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hICAM1 F
<400> 69
ccaggagaca ctgcagacag 20
<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hICAM1 R
<400> 70
cttcactgtc acctcggtcc 20
<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIER3 F
<400> 71
cctgatggct gaagagggtg 20
<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIER3 R
<400> 72
attaaagggc tcgaggacgg 20
<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL-13RA2 F
<400> 73
atgctgggaa ggtgaagacc 20
<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL-13RA2 R
<400> 74
ggcttacgca aaagcagacc 20
<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL-33 F
<400> 75
tcaggtgacg gtgttgatgg 20
<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL-33 R
<400> 76
ggagctccac agagtgttcc 20
<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL1B F
<400> 77
ccacctccag ggacaggata 20
<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL1B R
<400> 78
aacacgcagg acaggtacag 20
<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL6 F
<400> 79
agtgaggaac aagccagagc 20
<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL6 R
<400> 80
atttgtggtt gggtcagggg 20
<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL6ST F
<400> 81
acacagcagt ggtattgggg 20
<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL6ST R
<400> 82
actggacagt gctcgaagtg 20
<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL7R F
<400> 83
ccctagactg cagggagagt 20
<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL7R R
<400> 84
ggagagaaaa tggagggggc 20
<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL8 F
<400> 85
ctccaaacct ttccacccca 20
<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hIL8 R
<400> 86
ttccttgggg tccagacaga 20
<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA1 F
<400> 87
ggcagcacaa ttcatgcaca 20
<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA1 R
<400> 88
tgatcatctt ccagcggagc 20
<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA2 F
<400> 89
cacaaagaca caggtggggt 20
<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA2 R
<400> 90
tgggatgtct gggatgttgc 20
<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA3 F
<400> 91
ggacatgtgg cttggagtga 20
<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA3 R
<400> 92
gctggtcttc tgaccctgac 20
<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA4 F
<400> 93
tggagcttct gtctgtgctg 20
<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA4 R
<400> 94
ctcccgagcc agagttgatg 20
<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA5 F
<400> 95
acatctgtgt gcctgacctg 20
<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGA5 R
<400> 96
ctcacccaca ttctgggcat 20
<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGAV F
<400> 97
tccgattcca aactgggagc 20
<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGAV R
<400> 98
aaggccactg aagatggagc 20
<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB1 F
<400> 99
gtcgtgtgtg tgagtgcaac 20
<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB1 R
<400> 100
agacaccaca ctcgcagatg 20
<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB3 F
<400> 101
gccctgctca tctggaaact 20
<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB3 R
<400> 102
ttggtgaagg tagacgtggc 20
<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB5 F
<400> 103
cacccaaaat gtgcctggtg 20
<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hITGB5 R
<400> 104
tcaggacatg gaagctgctg 20
<210> 105
<211> 19
<212> DNA
<213> Artificial Sequence
<220>
<223> hKRTAP1-5 F
<400> 105
cagacagtcg tgtggaggg 19
<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hKRTAP1-5 R
<400> 106
gcaggactgt ccacagtagg 20
<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hLPXN F
<400> 107
tgactgagat gcaggccaag 20
<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hLPXN R
<400> 108
aggtcctgca attcctgctc 20
<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMAPK1 F
<400> 109
acctactgcc agagaaccct 20
<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMAPK1 R
<400> 110
tcgatggttg gtgctcgaat 20
<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMAPK3 F
<400> 111
accacattct gggcatcctg 20
<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMAPK3 R
<400> 112
cttggtcttg gagggcagag 20
<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMCL1 F
<400> 113
gaggaggagg aggacgagtt 20
<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMCL1 R
<400> 114
ctgcccattg gctttgtgtc 20
<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMIF F
<400> 115
cagaaccgct cctacagcaa 20
<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMIF R
<400> 116
aaggtggagt tgttccagcc 20
<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP1 F
<400> 117
agtggcccag tggttgaaaa 20
<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP1 R
<400> 118
ccacatcagg cactccacat 20
<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP2 F
<400> 119
ccctgtgtct tccccttcac 20
<210> 120
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP2 R
<400> 120
atcgtagttg gctgtggtcg 20
<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP3 F
<400> 121
cacagacctg actcggttcc 20
<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hMMP3 R
<400> 122
aggttctgga gggacaggtt 20
<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hVISFATIN F
<400> 123
tcggttctgg tggaggtttg 20
<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hVISFATIN R
<400> 124
ttgggatcag caactgggtc 20
<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hNPAS2 F
<400> 125
atcctgcagg ccaatatccg 20
<210> 126
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hNPAS2 R
<400> 126
ctgctgcagg aacatctgga 20
<210> 127
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPDGFA F
<400> 127
ggccaaggtg gaatacgtca 20
<210> 128
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPDGFA R
<400> 128
atccggattc aggcttgtgg 20
<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAT F
<400> 129
tacagccagc ctcagtttcg 20
<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAT R
<400> 130
gagctgatga gtatgccccc 20
<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAU F
<400> 131
ccaaaatgct gtgtgctgct 20
<210> 132
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAU R
<400> 132
ttgtccttca gggcacatcc 20
<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAUR F
<400> 133
ggcttgaaga tcaccagcct 20
<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLAUR R
<400> 134
tgcattcgag gtaacggctt 20
<210> 135
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLG F
<400> 135
ctacccaaat gctggcctga 20
<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPLG R
<400> 136
actcgcttct gttcctgagc 20
<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTEN F
<400> 137
tgtggtctgc cagctaaagg 20
<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTEN R
<400> 138
acacacaggt aacggctgag 20
<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTGS2 F
<400> 139
gttccacccg cagtacagaa 20
<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTGS2 R
<400> 140
agggcttcag cataaagcgt 20
<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTX3
<400> 141
cctgcatttg ggtcaaagcc 20
<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hPTX3 R
<400> 142
ctccacccac cacaaacact 20
<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hRAC1 F
<400> 143
catcacctat ccgcagggtc 20
<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hRAC1 R
<400> 144
tcggatcgct tcgtcaaaca 20
<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hRHOA F
<400> 145
ggtgatggag cctgtggaaa 20
<210> 146
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hRHOA R
<400> 146
tgtgtcccac aaagccaact 20
<210> 147
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINB2 F
<400> 147
gctggcacag gaggtgttat 20
<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINB2 R
<400> 148
agggtgagga aaatctgccg 20
<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINE 1 F
<400> 149
gggccatgga acaaggatga 20
<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINE 1 R
<400> 150
ccggaacagc ctgaagaagt 20
<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINE2 F
<400> 151
aagaaacgca ctttcgtggc 20
<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSERPINE2 R
<400> 152
ccgtggtagg gcagttcaat 20
<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSLC20A1 F
<400> 153
gcaactcgtg gcttcgtttt 20
<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSLC20A1 R
<400> 154
gaccacttga caccctcctg 20
<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSLIT2 F
<400> 155
aagcttcaga ccatcgccaa 20
<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSLIT2 R
<400> 156
agccacttga gatggcagtc 20
<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSMURF2 F
<400> 157
agatcctcgg ctgtctgcta 20
<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSMURF2 R
<400> 158
ctgaaccagg tctcgcttgt 20
<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSTAT3 F
<400> 159
ctgtgggaag aatcacgcct 20
<210> 160
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSTAT3 R
<400> 160
acatcctgaa ggtgctgctc 20
<210> 161
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSTC1 F
<400> 161
ttgctgaggt gcaggaagag 20
<210> 162
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSTC1 R
<400> 162
caggcttcgg acaagtctgt 20
<210> 163
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSDC4 F
<400> 163
ccctccactt ggaaggacac 20
<210> 164
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hSDC4 R
<400> 164
caggactaca gcctctccct 20
<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTAGLN F
<400> 165
aggtctggct gaagaatggc 20
<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTAGLN R
<400> 166
cacctgctcc atctgcttga 20
<210> 167
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTFPI2 F
<400> 167
ctgtctcctg cccctagact 20
<210> 168
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTFPI2 R
<400> 168
aaattgttgg cgttgccctc 20
<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTGFB1 F
<400> 169
tggtggaaac ccacaacgaa 20
<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTGFB1 R
<400> 170
gagcaacacg ggttcaggta 20
<210> 171
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTGFBR3 F
<400> 171
cctcagtcca catccaccac 20
<210> 172
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTGFBR3 R
<400> 172
ccacagaacc ctcagacacc 20
<210> 173
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTIMP1 F
<400> 173
ggggcttcac caagacctac 20
<210> 174
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTIMP1 R
<400> 174
ggaagccctt ttcagagcct 20
<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTMEM158 F
<400> 175
ctgctgccta gacttcagcc 20
<210> 176
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTMEM158 R
<400> 176
ctccacacca cgatgaccag 20
<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTNFAIP6 F
<400> 177
agcacggtct ggcaaataca 20
<210> 178
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hTNFAIP6 R
<400> 178
atccatccag cagcacagac 20
<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hVEGFA F
<400> 179
cttgccttgc tgctctacct 20
<210> 180
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hVEGFA R
<400> 180
gcagtagctg cgctgataga 20
<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hWNT5A F
<400> 181
cgcgaagaca ggcatcaaag 20
<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hWNT5A R
<400> 182
atctgcatca ccctgccaaa 20
<210> 183
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hGAPDH F
<400> 183
tcctgcacca ccaactgttt 20
<210> 184
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> hGAPDH R
<400> 184
gtccactgtc ttctgggtgg 20
<210> 185
<211> 1805
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1805)
<223> mRNA ACTA2
<400> 185
gcaggctctc tccccgcccc cgcggggcgg cgcgcactca cccacccgcg ccggagcgga 60
cctttggctt ggcttgtcag ggcttgtcca ggagttccgc tcctctctcc aaccggggtc 120
cccctccagc gaccctaaag cttcccagac ttccgcttca attcctgtcc gcaccccacg 180
cccacctcaa cgtggagcgc agtggtctcc gaggagcgcc ggagctgccc cgcctgccca 240
gcggggtcag cacttcgcat caaggcccaa gaaaagcaag tcctccagcg ttctgagcac 300
ccgggcctga gggaaggtcc taacagcccc cgggagccag tctccaacgc ctcccgcagc 360
agcccgccgc tcccaggtgc ccgcgtgcgc cgctgccgcc gcaatcccgc acgcgtcccg 420
cgcccgcccc actttgccta tccccgggac taagacggga atcctgtgaa gcagctccag 480
ctatgtgtga agaagaggac agcactgcct tggtgtgtga caatggctct gggctctgta 540
aggccggctt tgctggggac gatgctccca gggctgtttt cccatccatt gtgggacgtc 600
ccagacatca gggggtgatg gtgggaatgg gacaaaaaga cagctacgtg ggtgacgaag 660
cacagagcaa aagaggaatc ctgaccctga agtacccgat agaacatggc atcatcacca 720
actgggacga catggaaaag atctggcacc actctttcta caatgagctt cgtgttgccc 780
ctgaagagca tcccaccctg ctcacggagg cacccctgaa ccccaaggcc aaccgggaga 840
aaatgactca aattatgttt gagactttca atgtcccagc catgtatgtg gctatccagg 900
cggtgctgtc tctctatgcc tctggacgca caactggcat cgtgctggac tctggagatg 960
gtgtcaccca caatgtcccc atctatgagg gctatgcctt gccccatgcc atcatgcgtc 1020
tggatctggc tggccgagat ctcactgact acctcatgaa gatcctgact gagcgtggct 1080
attccttcgt tactactgct gagcgtgaga ttgtccggga catcaaggag aaactgtgtt 1140
atgtagctct ggactttgaa aatgagatgg ccactgccgc atcctcatcc tcccttgaga 1200
agagttacga gttgcctgat gggcaagtga tcaccatcgg aaatgaacgt ttccgctgcc 1260
cagagaccct gttccagcca tccttcatcg ggatggagtc tgctggcatc catgaaacca 1320
cctacaacag catcatgaag tgtgatattg acatcaggaa ggacctctat gctaacaatg 1380
tcctatcagg gggcaccact atgtaccctg gcattgccga ccgaatgcag aaggagatca 1440
cggccctagc acccagcacc atgaagatca agatcattgc ccctccggag cgcaaatact 1500
ctgtctggat cggtggctcc atcctggcct ctctgtccac cttccagcag atgtggatca 1560
gcaaacagga atacgatgaa gccgggcctt ccattgtcca ccgcaaatgc ttctaaaaca 1620
ctttcctgct cctctctgtc tctagcacac aactgtgaat gtcctgtgga attatgcctt 1680
cagttctttt ccaaatcatt cctagccaaa gctctgactc gttacctatg tgttttttaa 1740
taaatctgaa ataggctact ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1800
aaaaa 1805
<210> 186
<211> 5582
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5582)
<223> BAPER mRNA
<400> 186
agtggagacg cgccttctcg gctctggtcc gcgccctggg gccctggcct ccctggaggg 60
gctggggaac tggaagctgg gccgagagag ttcccgctgc agctatcgcg cagtccctcc 120
tgcgcccggg cgcccccagc gggttccggg aggcgcccgg tgagcccacg tctgttgcgg 180
cggagcgagc gcgctccggg agggccgaga gccggcgggg ctggcaggag ctctcgggcg 240
cccgcctccc tccttcgcgg acggtctccc gacacgccgg ctgagagccc ttttcgactg 300
tgagctgcgg cagctgagca gaggcggcgg cgcgggacct gcagtcgcca gggattccct 360
ccaggtgacg atgctctggt tctccggcgt cggggctctg gctgagcgtt actgccgccg 420
ctcgcctggg attacgtgct gcgtcttgct gctactcaat tgctcggggg tccccatgtc 480
tctggcttcc tccttcttga caggttctgt tgcaaaatgt gaaaatgaag gtgaagtcct 540
ccagattcca tttatcacag acaacccttg cataatgtgt gtctgcttga acaaggaagt 600
gacatgtaag agagagaagt gccccgtgct gtcccgagac tgtgccctgg ccatcaagca 660
gaggggagcc tgttgtgaac agtgcaaagg ttgcacctat gaaggaaata cctataacag 720
ctccttcaaa tggcagagcc cggctgagcc ttgtgttcta cgccagtgcc aggagggcgt 780
tgtcacagag tctggggtgc gctgtgttgt tcattgtaaa aaccctttgg agcatctggg 840
aatgtgctgc cccacatgtc caggctgtgt gtttgagggt gtgcagtatc aagaagggga 900
ggaatttcag ccagaaggaa gcaaatgtac caagtgttcc tgcactggag gcaggacaca 960
atgtgtgaga gaagtctgtc ccattctctc ctgtccccag caccttagtc acataccccc 1020
aggacagtgc tgccccaaat gtttgggtca gaggaaagtg tttgacctcc cttttgggag 1080
ctgcctcttt cgaagtgatg tttatgacaa tggatcctca tttctgtacg ataactgcac 1140
agcttgtacc tgcagggact ctactgtggt ttgcaagagg aagtgctccc accctggtgg 1200
ctgtgaccaa ggccaggagg gctgttgtga agagtgcctc ctacgagtgc ccccagaaga 1260
catcaaagta tgcaaatttg gcaacaagat tttccaggat ggagagatgt ggtcctctat 1320
caattgtacc atctgtgctt gtgtgaaagg caggacggag tgtcgcaata agcagtgcat 1380
tcccatcagt agctgcccac agggcaaaat tctcaacaga aaaggatgct gtcctatttg 1440
cactgaaaag cccggcgttt gcacggtgtt tggagatccc cactacaaca cttttgacgg 1500
tcggacattt aactttcagg ggacgtgtca gtacgttttg acaaaagact gctcctcccc 1560
tgcctcgccc ttccaggtgc tggtgaagaa cgacgcccgc cggacacgct ccttctcgtg 1620
gaccaagtcg gtggagctgg tgctgggcga gagcagggtc agcctgcagc agcacctcac 1680
cgtgcgctgg aacggctcgc gcatcgcgct cccctgccgc gcgccacact tccacatcga 1740
cctggatggc tacctcttga aagtgaccac caaagcaggt ttggaaatat cttgggatgg 1800
agacagtttt gtagaagtca tggctgcgcc gcatctcaag ggcaagctct gtggtctttg 1860
tggcaactac aatggacata aacgtgatga cttaattggt ggagatggaa acttcaagtt 1920
tgatgtggat gactttgctg aatcttggag ggtggagtcc aatgagttct gcaacagacc 1980
tcagagaaag ccagtgcctg aactgtgtca agggacagtc aaggtaaagc tccgggccca 2040
tcgagaatgc caaaagctca aatcctggga gtttcagacc tgccactcga ctgtggacta 2100
cgccactttc taccggtcct gtgtgacaga catgtgtgaa tgtccagtcc ataaaaactg 2160
ttattgcgag tcatttttgg catatacccg ggcctgccag agagagggca tcaaagtcca 2220
ctgggagcct cagcagaatt gtgcagccac ccagtgtaag catggtgctg tgtacgatac 2280
ctgtggtccg ggatgtatca agacgtgtga caactggaat gaaattggtc catgcaacaa 2340
gccgtgcgtt gctgggtgcc actgtccagc aaacttggtc cttcacaagg gaaggtgcat 2400
caagccagtc ctttgtcccc agcggtgacc tttgtttcga tccttaagac tctgaaatct 2460
ggtgactttg acactgaagc ggaagagcca atgaaggact gcagtatttg tgtgcccgat 2520
tctgtaaaca cacacacaca gagtatatat gtgtatatat atatagatat attcaaaaac 2580
attgcatcat ttatatgaac tataggggga ttattatatg tatatttttt gctataagac 2640
atgtattgtt tctaggatcc taacctgtaa gccattgaac atgttgtata aatacaccag 2700
gtgtttttaa tttaataagg tggcatgcag atacattgga tagtgttaac atcacataca 2760
tttgtcattt ttaaggaagt tttctaagag ccctcaattg cctgcctgta ttaattttag 2820
ttttgagtca ggatttgtaa tggagtggga aatgtgtttc tctggagaag ggcacattta 2880
tctaggggca tttcaggttt ccaaagaaag gaatgtatgc ctgggaaaga cagcaggaga 2940
ttggtgaccg gccctaatgg tgcatgaaaa gcgagtgata ggctgttaga atgtattagg 3000
tcatgggcta acattatttc caaaattgat tggctggttg ccaagaaata tatatttgtc 3060
actagggcat aaccgaagaa tcaagtgatt tcttgccatc cttgcgtagt cctcaagtct 3120
tctaatcatc tatgtgtgta tgatggatgt gaccatttat atgtcatgtg ttgaaattaa 3180
agggtgtctg gatgccatgt taattttatt gagcatgaga aagtatttga agaaactgtt 3240
gcacaacata tgatgaaatt ttgatttctc tgaatctcag agtaatttaa gatgggcaaa 3300
tccaatgagt tgatgtaacc catctacatt ttgtggctat ttcatgtata aaatgaaagg 3360
ctttagttat ttctagagga gtcccatcca acactatttg gcgactgtta atatgttata 3420
attattagac agtggaaaag cctttattga ctaattgatt taacctcagt ccaaagaaca 3480
gtctctatac ttgccctcat ttactgatag gctgctacta gttaccattt gattgtcttg 3540
actttcgtct tcagttgaat tggtgaaaac atcaacaaaa acaaaaccca ctgtgtctta 3600
aaataaaatg ttctgcattg tagtcaataa agggcttaag atgtaaaaca atgcattttc 3660
tctctcaaga tgtcctgtgt tatactttac aattagttgt atcaacttca gattcattaa 3720
attttaacag ctgtatttag ttataatttt tgtatcttac aacagtatat ataaagacta 3780
ttattaatag acaaaagcaa acccacgttt ttgacaagcc agcatattgc caatgctcgt 3840
caaagacatt tatgtttctt ttacattcat gacagctaaa gtattaactt ggaatttttt 3900
tttttttttt tgactggaaa atccctagtt gtttgaatta actgaataaa gtgcagggcg 3960
taatagtgac tggctggggg cactgggcct ttgtgttttt tttcattcct gtgtttggat 4020
actaatcacc ctcgtatctg cagcctgagg tagtcaggtc attgtttcaa tgctgccctt 4080
ggaaagaaga ctttgactta ggtgctttgg gatctaagtg tggtttgtga ctatccccat 4140
tatttaagca tttgggggtc tcacttttgc ttatctgtaa cacaaagagg ccatgtagta 4200
tagtgagcag ggttgagaat cgggaaaact agacccctgc cactaacagg ctaggagact 4260
ttgggcagta atgggaggca ctgagggttt gcaaatactt tcctacttgt aatctcattg 4320
attccctgct ctgccctgac aggaggggta gggaaaatca gttgacgttg cctggtggtt 4380
cctaccttct gtaaaacgaa cagattcctt aagattagct ttaaatccct tttcagttca 4440
ctgttggttc tcatctttga aagagggcag cataagggaa atgatggaga agggagaatt 4500
gtggatggtt atttatagct catgattcat ccaaggactg agttattctc cccatgaggc 4560
taaccggcct ctttcccaac acttaatcat ggcagccagg atgggtgaat gatgaaagct 4620
cttctgcatg agccggtttc atcatcttgg gtgggttgat tacaagtttg tgtggcattc 4680
ctttagctgg ggattagctt aatctctgta catttttctc atttctaatt gaagaagaaa 4740
gggagggcag agaggacaga aaattacttg ggtttactaa ttcaaagagc catctctgat 4800
gggagagggt gaggaaatca gctgaatggt tggcctgcat attctttttt aggccacagg 4860
ctacagctga gcaatggctt agtctaatga ttgggcacaa tgaggattta ccaagtgctt 4920
caatgagagc agtcctgttt cattcacatg ggatgttttc aattggttct tcaactaagc 4980
tcttgcagag tgagatgact tgaaataaaa atgttctatg aatattgaat ttgatgagaa 5040
acaagcaccc tcaatgaaga acaagcataa ttatgattct aattgcccat tgttggtact 5100
cagtaaaact aagttctttc ttctctccct ctgtaaatag gaatatttga gggtcctgac 5160
ctaaaatttt ttagctggga agaaaagata tctctttggc atcgacaaga gcaatttttg 5220
ttaaaactgt ggtacactaa gaatcactaa ctcttcaggt tgaaggcctc actcatctta 5280
actcgttgac tgcttcctga ccatcagacc gtcctgtaag agggcatctt tcaataagaa 5340
cgagaaagac ccaggaggtt gactagcttc tcccagcttt cactgaaaca cggataaacc 5400
atttcaactg gaaaactctt cctttttatg agatatttca gacacacaaa aaggcataga 5460
gaaaaatgtt gcaaacatcc atgactacat taccctaatt aagaaacata acctggtaag 5520
tagtcaataa atttttcttg aatcaataaa taaaacctaa taaatgctgt ctcatggttg 5580
ca 5582
<210> 187
<211> 741
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(741)
<223> CCL2 mRNA
<400> 187
gagaggctga gactaaccca gaaacatcca attctcaaac tgaagctcgc actctcgcct 60
ccagcatgaa agtctctgcc gcccttctgt gcctgctgct catagcagcc accttcattc 120
cccaagggct cgctcagcca gatgcaatca atgccccagt cacctgctgt tataacttca 180
ccaataggaa gatctcagtg cagaggctcg cgagctatag aagaatcacc agcagcaagt 240
gtcccaaaga agctgtgatc ttcaagacca ttgtggccaa ggagatctgt gctgacccca 300
agcagaagtg ggttcaggat tccatggacc acctggacaa gcaaacccaa actccgaaga 360
cttgaacact cactccacaa cccaagaatc tgcagctaac ttattttccc ctagctttcc 420
ccagacaccc tgttttattt tattataatg aattttgttt gttgatgtga aacattatgc 480
cttaagtaat gttaattctt atttaagtta ttgatgtttt aagtttatct ttcatggtac 540
tagtgttttt tagatacaga gacttgggga aattgctttt cctcttgaac cacagttcta 600
cccctgggat gttttgaggg tctttgcaag aatcattaat acaaagaatt ttttttaaca 660
ttccaatgca ttgctaaaat attattgtgg aaatgaatat tttgtaacta ttacaccaaa 720
taaatatatt tttgtacaaa a 741
<210> 188
<211> 1378
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1378)
<223> CH25H mRNA
<400> 188
agctgccttg cacagcctcg caatgagctg ccacaactgc tccgaccccc aggtcctttg 60
cagctccggg cagctgttcc tgcagcccct ctgggaccac ctgaggagct gggaggccct 120
cctacagtcg cccttcttcc cggtcatctt ctccatcacc acatacgtgg gcttttgcct 180
gcccttcgtg gtcctggata tcctgtgctc ctgggtgccc gccctgcggc gctacaagat 240
ccaccctgac ttctcgccat ccgcgcagca gctgctacct tgcctggggc agaccctcta 300
ccagcatgtg atgtttgtgt tccccgtgac gctgctgcat tgggcccgca gcccggccct 360
cctgccccac gaagctcccg agctgctcct gctgctgcac cacatcctgt tctgcctgct 420
actcttcgac atggagttct tcgtgtggca cctgctgcac cacaaggtgc cctggctgta 480
ccgcaccttc cacaaggtgc accaccagaa ctcgtcctcg ttcgcgctgg caacgcagta 540
tatgagcgtc tgggaactgt tttctttggg cttcttcgac atgatgaacg tcacactgct 600
cgggtgccac ccgctcacca ccctgacctt ccacgtggtc aacatctggc tttccgtgga 660
ggaccactcc ggctacaact tcccttggtc cactcacaga ctggtgccct tcgggtggta 720
cgggggtgtg gtgcaccacg acctgcatca ctctcacttt aactgcaact tcgctccgta 780
ctttacacac tgggacaaaa tactgggaac gctgcggact gcatctgtcc cagcgcggtg 840
atgtggctgc ggtgggtgcc cctaagactc gggactgctg tgcctttcac acttgaatga 900
agagaaacac ctgagctata tattttttta aagcaactaa cttattgctt tatgtttatc 960
tatgaaaacc atagataaaa tctgatgcat ttttgtaatc tgacaaagta atttacatac 1020
tgtttgtgta tcaatacaat tttgtgttct tggtattctt agtctagctc acctcaatag 1080
ccttgaatcc tgcatatgaa ttagacattc atcactggca tatttagaat atctctaaaa 1140
ggacttgttt gtagaataag gaattttcta tgtttcaaag tgttctaaaa cctggctaaa 1200
agaatgtatt tttgtggatg gtgttgactt ctgactctaa aagcaatcaa acatgtttct 1260
gctggacagt gaccaagaat tatagtacct tcttatattt ttttatagaa ctgtatattt 1320
attttgaaag aaatgttatt cgtgctttaa aaaggaaaaa aaaccatgaa tcaaataa 1378
<210> 189
<211> 5927
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5927)
<223> COL1A1 mRNA
<400> 189
tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag 60
gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt 120
ctagacatgt tcagctttgt ggacctccgg ctcctgctcc tcttagcggc caccgccctc 180
ctgacgcacg gccaagagga aggccaagtc gagggccaag acgaagacat cccaccaatc 240
acctgcgtac agaacggcct caggtaccat gaccgagacg tgtggaaacc cgagccctgc 300
cggatctgcg tctgcgacaa cggcaaggtg ttgtgcgatg acgtgatctg tgacgagacc 360
aagaactgcc ccggcgccga agtccccgag ggcgagtgct gtcccgtctg ccccgacggc 420
tcagagtcac ccaccgacca agaaaccacc ggcgtcgagg gacccaaggg agacactggc 480
ccccgaggcc caaggggacc cgcaggcccc cctggccgag atggcatccc tggacagcct 540
ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct cggaggaaac 600
tttgctcccc agctgtctta tggctatgat gagaaatcaa ccggaggaat ttccgtgcct 660
ggccccatgg gtccctctgg tcctcgtggt ctccctggcc cccctggtgc acctggtccc 720
caaggcttcc aaggtccccc tggtgagcct ggcgagcctg gagcttcagg tcccatgggt 780
ccccgaggtc ccccaggtcc ccctggaaag aatggagatg atggggaagc tggaaaacct 840
ggtcgtcctg gtgagcgtgg gcctcctggg cctcagggtg ctcgaggatt gcccggaaca 900
gctggcctcc ctggaatgaa gggacacaga ggtttcagtg gtttggatgg tgccaaggga 960
gatgctggtc ctgctggtcc taagggtgag cctggcagcc ctggtgaaaa tggagctcct 1020
ggtcagatgg gcccccgtgg cctgcctggt gagagaggtc gccctggagc ccctggccct 1080
gctggtgctc gtggaaatga tggtgctact ggtgctgccg ggccccctgg tcccaccggc 1140
cccgctggtc ctcctggctt ccctggtgct gttggtgcta agggtgaagc tggtccccaa 1200
gggccccgag gctctgaagg tccccagggt gtgcgtggtg agcctggccc ccctggccct 1260
gctggtgctg ctggccctgc tggaaaccct ggtgctgatg gacagcctgg tgctaaaggt 1320
gccaatggtg ctcctggtat tgctggtgct cctggcttcc ctggtgcccg aggcccctct 1380
ggaccccagg gccccggcgg ccctcctggt cccaagggta acagcggtga acctggtgct 1440
cctggcagca aaggagacac tggtgctaag ggagagcctg gccctgttgg tgttcaagga 1500
ccccctggcc ctgctggaga ggaaggaaag cgaggagctc gaggtgaacc cggacccact 1560
ggcctgcccg gaccccctgg cgagcgtggt ggacctggta gccgtggttt ccctggcgca 1620
gatggtgttg ctggtcccaa gggtcccgct ggtgaacgtg gttctcctgg ccctgctggc 1680
cccaaaggat ctcctggtga agctggtcgt cccggtgaag ctggtctgcc tggtgccaag 1740
ggtctgactg gaagccctgg cagccctggt cctgatggca aaactggccc ccctggtccc 1800
gccggtcaag atggtcgccc cggaccccca ggcccacctg gtgcccgtgg tcaggctggt 1860
gtgatgggat tccctggacc taaaggtgct gctggagagc ccggcaaggc tggagagcga 1920
ggtgttcccg gaccccctgg cgctgtcggt cctgctggca aagatggaga ggctggagct 1980
cagggacccc ctggccctgc tggtcccgct ggcgagagag gtgaacaagg ccctgctggc 2040
tcccccggat tccagggtct ccctggtcct gctggtcctc caggtgaagc aggcaaacct 2100
ggtgaacagg gtgttcctgg agaccttggc gcccctggcc cctctggagc aagaggcgag 2160
agaggtttcc ctggcgagcg tggtgtgcaa ggtccccctg gtcctgctgg tccccgaggg 2220
gccaacggtg ctcccggcaa cgatggtgct aagggtgatg ctggtgcccc tggagctccc 2280
ggtagccagg gcgcccctgg ccttcaggga atgcctggtg aacgtggtgc agctggtctt 2340
ccagggccta agggtgacag aggtgatgct ggtcccaaag gtgctgatgg ctctcctggc 2400
aaagatggcg tccgtggtct gactggcccc attggtcctc ctggccctgc tggtgcccct 2460
ggtgacaagg gtgaaagtgg tcccagcggc cctgctggtc ccactggagc tcgtggtgcc 2520
cccggagacc gtggtgagcc tggtcccccc ggccctgctg gctttgctgg cccccctggt 2580
gctgacggcc aacctggtgc taaaggcgaa cctggtgatg ctggtgctaa aggcgatgct 2640
ggtccccctg gccctgccgg acccgctgga ccccctggcc ccattggtaa tgttggtgct 2700
cctggagcca aaggtgctcg cggcagcgct ggtccccctg gtgctactgg tttccctggt 2760
gctgctggcc gagtcggtcc tcctggcccc tctggaaatg ctggaccccc tggccctcct 2820
ggtcctgctg gcaaagaagg cggcaaaggt ccccgtggtg agactggccc tgctggacgt 2880
cctggtgaag ttggtccccc tggtccccct ggccctgctg gcgagaaagg atcccctggt 2940
gctgatggtc ctgctggtgc tcctggtact cccgggcctc aaggtattgc tggacagcgt 3000
ggtgtggtcg gcctgcctgg tcagagagga gagagaggct tccctggtct tcctggcccc 3060
tctggtgaac ctggcaaaca aggtccctct ggagcaagtg gtgaacgtgg tccccctggt 3120
cccatgggcc cccctggatt ggctggaccc cctggtgaat ctggacgtga gggggctcct 3180
ggtgccgaag gttcccctgg acgagacggt tctcctggcg ccaagggtga ccgtggtgag 3240
accggccccg ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc 3300
cctgctggca agagtggtga tcgtggtgag actggtcctg ctggtcccgc cggtcctgtc 3360
ggccctgttg gcgcccgtgg ccccgccgga ccccaaggcc cccgtggtga caagggtgag 3420
acaggcgaac agggcgacag aggcataaag ggtcaccgtg gcttctctgg cctccagggt 3480
ccccctggcc ctcctggctc tcctggtgaa caaggtccct ctggagcctc tggtcctgct 3540
ggtccccgag gtccccctgg ctctgctggt gctcctggca aagatggact caacggtctc 3600
cctggcccca ttgggccccc tggtcctcgc ggtcgcactg gtgatgctgg tcctgttggt 3660
ccccccggcc ctcctggacc tcctggtccc cctggtcctc ccagcgctgg tttcgacttc 3720
agcttcctgc cccagccacc tcaagagaag gctcacgatg gtggccgcta ctaccgggct 3780
gatgatgcca atgtggttcg tgaccgtgac ctcgaggtgg acaccaccct caagagcctg 3840
agccagcaga tcgagaacat ccggagccca gagggcagcc gcaagaaccc cgcccgcacc 3900
tgccgtgacc tcaagatgtg ccactctgac tggaagagtg gagagtactg gattgacccc 3960
aaccaaggct gcaacctgga tgccatcaaa gtcttctgca acatggagac tggtgagacc 4020
tgcgtgtacc ccactcagcc cagtgtggcc cagaagaact ggtacatcag caagaacccc 4080
aaggacaaga ggcatgtctg gttcggcgag agcatgaccg atggattcca gttcgagtat 4140
ggcggccagg gctccgaccc tgccgatgtg gccatccagc tgaccttcct gcgcctgatg 4200
tccaccgagg cctcccagaa catcacctac cactgcaaga acagcgtggc ctacatggac 4260
cagcagactg gcaacctcaa gaaggccctg ctcctccagg gctccaacga gatcgagatc 4320
cgcgccgagg gcaacagccg cttcacctac agcgtcactg tcgatggctg cacgagtcac 4380
accggagcct ggggcaagac agtgattgaa tacaaaacca ccaagacctc ccgcctgccc 4440
atcatcgatg tggccccctt ggacgttggt gccccagacc aggaattcgg cttcgacgtt 4500
ggccctgtct gcttcctgta aactccctcc atcccaacct ggctccctcc cacccaacca 4560
actttccccc caacccggaa acagacaagc aacccaaact gaaccccctc aaaagccaaa 4620
aaatgggaga caatttcaca tggactttgg aaaatatttt tttcctttgc attcatctct 4680
caaacttagt ttttatcttt gaccaaccga acatgaccaa aaaccaaaag tgcattcaac 4740
cttaccaaaa aaaaaaaaaa aaaaagaata aataaataac tttttaaaaa aggaagcttg 4800
gtccacttgc ttgaagaccc atgcgggggt aagtcccttt ctgcccgttg ggcttatgaa 4860
accccaatgc tgccctttct gctcctttct ccacaccccc cttggggcct cccctccact 4920
ccttcccaaa tctgtctccc cagaagacac aggaaacaat gtattgtctg cccagcaatc 4980
aaaggcaatg ctcaaacacc caagtggccc ccaccctcag cccgctcctg cccgcccagc 5040
acccccaggc cctgggggac ctggggttct cagactgcca aagaagcctt gccatctggc 5100
gctcccatgg ctcttgcaac atctcccctt cgtttttgag ggggtcatgc cgggggagcc 5160
accagcccct cactgggttc ggaggagagt caggaagggc cacgacaaag cagaaacatc 5220
ggatttgggg aacgcgtgtc aatcccttgt gccgcagggc tgggcgggag agactgttct 5280
gttccttgtg taactgtgtt gctgaaagac tacctcgttc ttgtcttgat gtgtcaccgg 5340
ggcaactgcc tgggggcggg gatgggggca gggtggaagc ggctccccat tttataccaa 5400
aggtgctaca tctatgtgat gggtggggtg gggagggaat cactggtgct atagaaattg 5460
agatgccccc ccaggccagc aaatgttcct ttttgttcaa agtctatttt tattccttga 5520
tatttttctt tttttttttt tttttttgtg gatggggact tgtgaatttt tctaaaggtg 5580
ctatttaaca tgggaggaga gcgtgtgcgg ctccagccca gcccgctgct cactttccac 5640
cctctctcca cctgcctctg gcttctcagg cctctgctct ccgacctctc tcctctgaaa 5700
ccctcctcca cagctgcagc ccatcctccc ggctccctcc tagtctgtcc tgcgtcctct 5760
gtccccgggt ttcagagaca acttcccaaa gcacaaagca gtttttcccc ctaggggtgg 5820
gaggaagcaa aagactctgt acctattttg tatgtgtata ataatttgag atgtttttaa 5880
ttattttgat tgctggaata aagcatgtgg aaatgaccca aacataa 5927
<210> 190
<211> 5411
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5411)
<223> COL1A2 mRNA
<400> 190
gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc 60
ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc 120
tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc 180
gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc 240
cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc 300
gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg 360
ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg 420
gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc 480
tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa 540
tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa 600
aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt 660
ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga 720
aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt 780
gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct 840
ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa 900
gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt 960
gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat 1020
ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc 1080
cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga 1140
cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg 1200
ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc 1260
aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt 1320
gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac 1380
ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc 1440
cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga 1500
cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc 1560
ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct 1620
aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt 1680
tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt 1740
ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag 1800
cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga 1860
aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct 1920
ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat 1980
cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt 2040
cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa 2100
ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc 2160
gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt 2220
cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact 2280
ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa 2340
cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga 2400
gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga 2460
ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc 2520
cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt 2580
cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat 2640
ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc 2700
aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc 2760
ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct 2820
ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt 2880
tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt 2940
gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct 3000
ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct 3060
cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt 3120
ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct 3180
ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa 3240
gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga 3300
cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct 3360
ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct 3420
tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc 3480
attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag 3540
ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct 3600
cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga 3660
aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag 3720
ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta 3780
agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc 3840
tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac 3900
aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc 3960
cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac 4020
caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt 4080
atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag 4140
aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa 4200
ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat 4260
gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact 4320
ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag 4380
ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa 4440
tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat 4500
attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc 4560
tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct 4620
ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca 4680
catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc 4740
aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca 4800
ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa 4860
aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag 4920
tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat 4980
ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc 5040
ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag 5100
aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa 5160
atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg 5220
cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca 5280
tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt 5340
atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca 5400
aaagaacata t 5411
<210> 191
<211> 5490
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5490)
<223> COL3A1 mRNA
<400> 191
ggctgagttt tatgacgggc ccggtgctga agggcaggga acaacttgat ggtgctactt 60
tgaactgctt ttcttttctc ctttttgcac aaagagtctc atgtctgata tttagacatg 120
atgagctttg tgcaaaaggg gagctggcta cttctcgctc tgcttcatcc cactattatt 180
ttggcacaac aggaagctgt tgaaggagga tgttcccatc ttggtcagtc ctatgcggat 240
agagatgtct ggaagccaga accatgccaa atatgtgtct gtgactcagg atccgttctc 300
tgcgatgaca taatatgtga cgatcaagaa ttagactgcc ccaacccaga aattccattt 360
ggagaatgtt gtgcagtttg cccacagcct ccaactgctc ctactcgccc tcctaatggt 420
caaggacctc aaggccccaa gggagatcca ggccctcctg gtattcctgg gagaaatggt 480
gaccctggta ttccaggaca accagggtcc cctggttctc ctggcccccc tggaatctgt 540
gaatcatgcc ctactggtcc tcagaactat tctccccagt atgattcata tgatgtcaag 600
tctggagtag cagtaggagg actcgcaggc tatcctggac cagctggccc cccaggccct 660
cccggtcccc ctggtacatc tggtcatcct ggttcccctg gatctccagg ataccaagga 720
ccccctggtg aacctgggca agctggtcct tcaggccctc caggacctcc tggtgctata 780
ggtccatctg gtcctgctgg aaaagatgga gaatcaggta gacccggacg acctggagag 840
cgaggattgc ctggacctcc aggtatcaaa ggtccagctg ggatacctgg attccctggt 900
atgaaaggac acagaggctt cgatggacga aatggagaaa agggtgaaac aggtgctcct 960
ggattaaagg gtgaaaatgg tcttccaggc gaaaatggag ctcctggacc catgggtcca 1020
agaggggctc ctggtgagcg aggacggcca ggacttcctg gggctgcagg tgctcggggt 1080
aatgacggtg ctcgaggcag tgatggtcaa ccaggccctc ctggtcctcc tggaactgcc 1140
ggattccctg gatcccctgg tgctaagggt gaagttggac ctgcagggtc tcctggttca 1200
aatggtgccc ctggacaaag aggagaacct ggacctcagg gacacgctgg tgctcaaggt 1260
cctcctggcc ctcctgggat taatggtagt cctggtggta aaggcgaaat gggtcccgct 1320
ggcattcctg gagctcctgg actgatggga gcccggggtc ctccaggacc agccggtgct 1380
aatggtgctc ctggactgcg aggtggtgca ggtgagcctg gtaagaatgg tgccaaagga 1440
gagcccggac cacgtggtga acgcggtgag gctggtattc caggtgttcc aggagctaaa 1500
ggcgaagatg gcaaggatgg atcacctgga gaacctggtg caaatgggct tccaggagct 1560
gcaggagaaa ggggtgcccc tgggttccga ggacctgctg gaccaaatgg catcccagga 1620
gaaaagggtc ctgctggaga gcgtggtgct ccaggccctg cagggcccag aggagctgct 1680
ggagaacctg gcagagatgg cgtccctgga ggtccaggaa tgaggggcat gcccggaagt 1740
ccaggaggac caggaagtga tgggaaacca gggcctcccg gaagtcaagg agaaagtggt 1800
cgaccaggtc ctcctgggcc atctggtccc cgaggtcagc ctggtgtcat gggcttcccc 1860
ggtcctaaag gaaatgatgg tgctcctggt aagaatggag aacgaggtgg ccctggagga 1920
cctggccctc agggtcctcc tggaaagaat ggtgaaactg gacctcaggg acccccaggg 1980
cctactgggc ctggtggtga caaaggagac acaggacccc ctggtccaca aggattacaa 2040
ggcttgcctg gtacaggtgg tcctccagga gaaaatggaa aacctgggga accaggtcca 2100
aagggtgatg ccggtgcacc tggagctcca ggaggcaagg gtgatgctgg tgcccctggt 2160
gaacgtggac ctcctggatt ggcaggggcc ccaggactta gaggtggagc tggtccccct 2220
ggtcccgaag gaggaaaggg tgctgctggt cctcctgggc cacctggtgc tgctggtact 2280
cctggtctgc aaggaatgcc tggagaaaga ggaggtcttg gaagtcctgg tccaaagggt 2340
gacaagggtg aaccaggcgg tccaggtgct gatggtgtcc cagggaaaga tggcccaagg 2400
ggtcctactg gtcctattgg tcctcctggc ccagctggcc agcctggaga taagggtgaa 2460
ggtggtgccc ccggacttcc aggtatagct ggacctcgtg gtagccctgg tgagagaggt 2520
gaaactggcc ctccaggacc tgctggtttc cctggtgctc ctggacagaa tggtgaacct 2580
ggtggtaaag gagaaagagg ggctccgggt gagaaaggtg aaggaggccc tcctggagtt 2640
gcaggacccc ctggaggttc tggacctgct ggtcctcctg gtccccaagg tgtcaaaggt 2700
gaacgtggca gtcctggtgg acctggtgct gctggcttcc ctggtgctcg tggtcttcct 2760
ggtcctcctg gtagtaatgg taacccagga cccccaggtc ccagcggttc tccaggcaag 2820
gatgggcccc caggtcctgc gggtaacact ggtgctcctg gcagccctgg agtgtctgga 2880
ccaaaaggtg atgctggcca accaggagag aagggatcgc ctggtgccca gggcccacca 2940
ggagctccag gcccacttgg gattgctggg atcactggag cacggggtct tgcaggacca 3000
ccaggcatgc caggtcctag gggaagccct ggccctcagg gtgtcaaggg tgaaagtggg 3060
aaaccaggag ctaacggtct cagtggagaa cgtggtcccc ctggacccca gggtcttcct 3120
ggtctggctg gtacagctgg tgaacctgga agagatggaa accctggatc agatggtctt 3180
ccaggccgag atggatctcc tggtggcaag ggtgatcgtg gtgaaaatgg ctctcctggt 3240
gcccctggcg ctcctggtca tccaggccca cctggtcctg tcggtccagc tggaaagagt 3300
ggtgacagag gagaaagtgg ccctgctggc cctgctggtg ctcccggtcc tgctggttcc 3360
cgaggtgctc ctggtcctca aggcccacgt ggtgacaaag gtgaaacagg tgaacgtgga 3420
gctgctggca tcaaaggaca tcgaggattc cctggtaatc caggtgcccc aggttctcca 3480
ggccctgctg gtcagcaggg tgcaatcggc agtccaggac ctgcaggccc cagaggacct 3540
gttggaccca gtggacctcc tggcaaagat ggaaccagtg gacatccagg tcccattgga 3600
ccaccagggc ctcgaggtaa cagaggtgaa agaggatctg agggctcccc aggccaccca 3660
gggcaaccag gccctcctgg acctcctggt gcccctggtc cttgctgtgg tggtgttgga 3720
gccgctgcca ttgctgggat tggaggtgaa aaagctggcg gttttgcccc gtattatgga 3780
gatgaaccaa tggatttcaa aatcaacacc gatgagatta tgacttcact caagtctgtt 3840
aatggacaaa tagaaagcct cattagtcct gatggttctc gtaaaaaccc cgctagaaac 3900
tgcagagacc tgaaattctg ccatcctgaa ctcaagagtg gagaatactg ggttgaccct 3960
aaccaaggat gcaaattgga tgctatcaag gtattctgta atatggaaac tggggaaaca 4020
tgcataagtg ccaatccttt gaatgttcca cggaaacact ggtggacaga ttctagtgct 4080
gagaagaaac acgtttggtt tggagagtcc atggatggtg gttttcagtt tagctacggc 4140
aatcctgaac ttcctgaaga tgtccttgat gtgcagctgg cattccttcg acttctctcc 4200
agccgagctt cccagaacat cacatatcac tgcaaaaata gcattgcata catggatcag 4260
gccagtggaa atgtaaagaa ggccctgaag ctgatggggt caaatgaagg tgaattcaag 4320
gctgaaggaa atagcaaatt cacctacaca gttctggagg atggttgcac gaaacacact 4380
ggggaatgga gcaaaacagt ctttgaatat cgaacacgca aggctgtgag actacctatt 4440
gtagatattg caccctatga cattggtggt cctgatcaag aatttggtgt ggacgttggc 4500
cctgtttgct ttttataaac caaactctat ctgaaatccc aacaaaaaaa atttaactcc 4560
atatgtgttc ctcttgttct aatcttgtca accagtgcaa gtgaccgaca aaattccagt 4620
tatttatttc caaaatgttt ggaaacagta taatttgaca aagaaaaatg atacttctct 4680
ttttttgctg ttccaccaaa tacaattcaa atgctttttg ttttattttt ttaccaattc 4740
caatttcaaa atgtctcaat ggtgctataa taaataaact tcaacactct ttatgataac 4800
aacactgtgt tatattcttt gaatcctagc ccatctgcag agcaatgact gtgctcacca 4860
gtaaaagata acctttcttt ctgaaatagt caaatacgaa attagaaaag ccctccctat 4920
tttaactacc tcaactggtc agaaacacag attgtattct atgagtccca gaagatgaaa 4980
aaaattttat acgttgataa aacttataaa tttcattgat taatctcctg gaagattggt 5040
ttaaaaagaa aagtgtaatg caagaattta aagaaatatt tttaaagcca caattatttt 5100
aatattggat atcaactgct tgtaaaggtg ctcctctttt ttcttgtcat tgctggtcaa 5160
gattactaat atttgggaag gctttaaaga cgcatgttat ggtgctaatg tactttcact 5220
tttaaactct agatcagaat tgttgacttg cattcagaac ataaatgcac aaaatctgta 5280
catgtctccc atcagaaaga ttcattggca tgccacaggg gattctcctc cttcatcctg 5340
taaaggtcaa caataaaaac caaattatgg ggctgctttt gtcacactag catagagaat 5400
gtgttgaaat ttaactttgt aagcttgtat gtggttgttg atcttttttt tccttacaga 5460
cacccataat aaaatatcat attaaaattc 5490
<210> 192
<211> 6540
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6540)
<223> COL4A1 mRNA
<400> 192
aggtctccgc ttggagccgc cgcacccggg acggtgcgta gcgctggaag tccggccttc 60
cgagagctag ctgtccgccg cggcccccgc acgccgggca gccgtccctc gccgcctcgg 120
gcgcgccacc atggggcccc ggctcagcgt ctggctgctg ctgctgcccg ccgcccttct 180
gctccacgag gagcacagcc gggccgctgc gaagggtggc tgtgctggct ctggctgtgg 240
caaatgtgac tgccatggag tgaagggaca aaagggtgaa agaggcctcc cggggttaca 300
aggtgtcatt gggtttcctg gaatgcaagg acctgagggg ccacagggac caccaggaca 360
aaagggtgat actggagaac caggactacc tggaacaaaa gggacaagag gacctccggg 420
agcatctggc taccctggaa acccaggact tcccggaatt cctggccaag acggcccgcc 480
aggcccccca ggtattccag gatgcaatgg cacaaagggg gagagagggc cgctcgggcc 540
tcctggcttg cctggtttcg ctggaaatcc cggaccacca ggcttaccag ggatgaaggg 600
tgatccaggt gagatacttg gccatgtgcc cgggatgctg ttgaaaggtg aaagaggatt 660
tcccggaatc ccagggactc caggcccacc aggactgcca gggcttcaag gtcctgttgg 720
gcctccagga tttaccggac caccaggtcc cccaggccct cccggccctc caggtgaaaa 780
gggacaaatg ggcttaagtt ttcaaggacc aaaaggtgac aagggtgacc aaggggtcag 840
tgggcctcca ggagtaccag gacaagctca agttcaagaa aaaggagact tcgccaccaa 900
gggagaaaag ggccaaaaag gtgaacctgg atttcagggg atgccagggg tcggagagaa 960
aggtgaaccc ggaaaaccag gacccagagg caaacccgga aaagatggtg acaaagggga 1020
aaaagggagt cccggttttc ctggtgaacc cgggtaccca ggactcatag gccgccaggg 1080
cccgcaggga gaaaagggtg aagcaggtcc tcctggccca cctggaattg ttataggcac 1140
aggacctttg ggagaaaaag gagagagggg ctaccctgga actccggggc caagaggaga 1200
gccaggccca aaaggtttcc caggactacc aggccaaccc ggacctccag gcctccctgt 1260
acctgggcag gctggtgccc ctggcttccc tggtgaaaga ggagaaaaag gtgaccgagg 1320
atttcctggt acatctctgc caggaccaag tggaagagat gggctcccgg gtcctcctgg 1380
ttcccctggg ccccctgggc agcctggcta cacaaatgga attgtggaat gtcagcccgg 1440
acctccaggt gaccagggtc ctcctggaat tccagggcag ccaggattta taggcgaaat 1500
tggagagaaa ggtcaaaaag gagagagttg cctcatctgt gatatagacg gatatcgggg 1560
gcctcccggg ccacagggac ccccgggaga aataggtttc ccagggcagc caggggccaa 1620
gggcgacaga ggtttgcctg gcagagatgg tgttgcagga gtgccaggcc ctcaaggtac 1680
accagggctg ataggccagc caggagccaa gggggagcct ggtgagtttt atttcgactt 1740
gcggctcaaa ggtgacaaag gagacccagg ctttccagga cagcccggca tgccagggag 1800
agcgggttct cctggaagag atggccatcc gggtcttcct ggccccaagg gctcgccggg 1860
ttctgtagga ttgaaaggag agcgtggccc ccctggagga gttggattcc caggcagtcg 1920
tggtgacacc ggcccccctg ggcctccagg atatggtcct gctggtccca ttggtgacaa 1980
aggacaagca ggctttcctg gaggccctgg atccccaggc ctgccaggtc caaagggtga 2040
accaggaaaa attgttcctt taccaggccc ccctggagca gaaggactgc cggggtcccc 2100
aggcttccca ggtccccaag gagaccgagg ctttcccgga accccaggaa ggccaggcct 2160
gccaggagag aagggcgctg tgggccagcc aggcattgga tttccagggc cccccggccc 2220
caaaggtgtt gacggcttac ctggagacat ggggccaccg gggactccag gtcgcccggg 2280
atttaatggc ttacctggga acccaggtgt gcagggccag aagggagagc ctggagttgg 2340
tctaccggga ctcaaaggtt tgccaggtct tcccggcatt cctggcacac ccggggagaa 2400
ggggagcatt ggggtaccag gcgttcctgg agaacatgga gcgatcggac cccctgggct 2460
tcaggggatc agaggtgaac cgggacctcc tggattgcca ggctccgtgg ggtctccagg 2520
agttccagga ataggccccc ctggagctag gggtccccct ggaggacagg gaccaccggg 2580
gttgtcaggc cctcctggaa taaaaggaga gaagggtttc cccggattcc ctggactgga 2640
catgccgggc cctaaaggag ataaaggggc tcaaggactc cctggcataa cgggacagtc 2700
ggggctccct ggccttcctg gacagcaggg ggctcctggg attcctgggt ttccaggttc 2760
caagggagaa atgggcgtca tggggacccc cgggcagccg ggctcaccag gaccagtggg 2820
tgctcctgga ttaccgggtg aaaaagggga ccatggcttt ccgggctcct caggacccag 2880
gggagaccct ggcttgaaag gtgataaggg ggatgtcggt ctccctggca agcctggctc 2940
catggataag gtggacatgg gcagcatgaa gggccagaaa ggagaccaag gagagaaagg 3000
acaaattgga ccaattggtg agaagggatc ccgaggagac cctgggaccc caggagtgcc 3060
tggaaaggac gggcaggcag gacagcctgg gcagccagga cctaaaggtg atccaggtat 3120
aagtggaacc ccaggtgctc caggacttcc gggaccaaaa ggatctgttg gtggaatggg 3180
cttgccagga acacctggag agaaaggtgt gcctggcatc cctggcccac aaggttcacc 3240
tggcttacct ggagacaaag gtgcaaaagg agagaaaggg caggcaggcc cacctggcat 3300
aggcatccca gggctgcgag gtgaaaaggg agatcaaggg atagcgggtt tcccaggaag 3360
ccctggagag aagggagaaa aaggaagcat tgggatccca ggaatgccag ggtccccagg 3420
ccttaaaggg tctcccggga gtgttggcta tccaggaagt cctgggctac ctggagaaaa 3480
aggtgacaaa ggcctcccag gattggatgg catccctggt gtcaaaggag aagcaggtct 3540
tcctgggact cctggcccca caggcccagc tggccagaaa ggggagccag gcagtgatgg 3600
aatcccgggg tcagcaggag agaagggtga accaggtcta ccaggaagag gattcccagg 3660
gtttccaggg gccaaaggag acaaaggttc aaagggtgag gtgggtttcc caggattagc 3720
cgggagccca ggaattcctg gatccaaagg agagcaagga ttcatgggtc ctccggggcc 3780
ccagggacag ccggggttac cgggatcccc aggccatgcc acggaggggc ccaaaggaga 3840
ccgcggacct cagggccagc ctggcctgcc aggacttccg ggacccatgg ggcctccagg 3900
gcttcctggg attgatggag ttaaaggtga caaaggaaat ccaggctggc caggagcacc 3960
cggtgtccca gggcccaagg gagaccctgg attccagggc atgcctggta ttggtggctc 4020
tccaggaatc acaggctcta agggtgatat ggggcctcca ggagttccag gatttcaagg 4080
tccaaaaggt cttcctggcc tccagggaat taaaggtgat caaggcgatc aaggcgtccc 4140
gggagctaaa ggtctcccgg gtcctcctgg ccccccaggt ccttacgaca tcatcaaagg 4200
ggagcccggg ctccctggtc ctgagggccc cccagggctg aaagggcttc agggactgcc 4260
aggcccgaaa ggccagcaag gtgttacagg attggtgggt atacctggac ctccaggtat 4320
tcctgggttt gacggtgccc ctggccagaa aggagagatg ggacctgccg ggcctactgg 4380
tccaagagga tttccaggtc caccaggccc cgatgggttg ccaggatcca tggggccccc 4440
aggcacccca tctgttgatc acggcttcct tgtgaccagg catagtcaaa caatagatga 4500
cccacagtgt ccttctggga ccaaaattct ttaccacggg tactctttgc tctacgtgca 4560
aggcaatgaa cgggcccatg gccaggactt gggcacggcc ggcagctgcc tgcgcaagtt 4620
cagcacaatg cccttcctgt tctgcaatat taacaacgtg tgcaactttg catcacgaaa 4680
tgactactcg tactggctgt ccacccctga gcccatgccc atgtcaatgg cacccatcac 4740
gggggaaaac ataagaccat ttattagtag gtgtgctgtg tgtgaggcgc ctgccatggt 4800
gatggccgtg cacagccaga ccattcagat cccaccgtgc cccagcgggt ggtcctcgct 4860
gtggatcggc tactcttttg tgatgcacac cagcgctggt gcagaaggct ctggccaagc 4920
cctggcgtcc cccggctcct gcctggagga gtttagaagt gcgccattca tcgagtgtca 4980
cggccgtggg acctgcaatt actacgcaaa cgcttacagc ttttggctcg ccaccataga 5040
gaggagcgag atgttcaaga agcctacgcc gtccaccttg aaggcagggg agctgcgcac 5100
gcacgtcagc cgctgccaag tctgtatgag aagaacataa tgaagcctga ctcagctaat 5160
gtcacaacat ggtgctactt cttcttcttt ttgttaacag caacgaaccc tagaaatata 5220
tcctgtgtac ctcactgtcc aatatgaaaa ccgtaaagtg ccttatagga atttgcgtaa 5280
ctaacacacc ctgcttcatt gacctctact tgctgaagga gaaaaagaca gcgataagct 5340
ttcaatagtg gcataccaaa tggcactttt gatgaaataa aatatcaata ttttctgcaa 5400
tccaatgcac tgatgtgtga agtgagaact ccatcagaaa accaaagggt gctaggaggt 5460
gtgggtgcct tccatactgt ttgcccattt tcattcttgt attataatta attttctacc 5520
cccagagata aatgtttgtt tatatcactg tctagctgtt tcaaaattta ggtcccttgg 5580
tctgtacaaa taatagcaat gtaaaaatgg ttttttgaac ctccaaatgg aattacagac 5640
tcagtagcca tatcttccaa ccccccagta taaatttctg tctttctgct atgtgtggta 5700
ctttgcagct gcttttgcag aaatcacaat tttcctgtgg aataaagatg gtccaaaaat 5760
agtcaaaaat taaatatata tatatattag taatttatat agatgtcagc aattaggcag 5820
atcaaggttt agtttaactt ccactgttaa aataaagctt acatagtttt cttcctttga 5880
aagactgtgc tgtcctttaa cataggtttt taaagactag gatattgaat gtgaaacatc 5940
cgttttcatt gttcacttct aaaccaaaaa ttatgtgttg ccaaaaccaa acccaggttc 6000
atgaatatgg tgtctattat agtgaaacat gtactttgag cttattgttt ttattctgta 6060
ttaaatattt tcagggtttt aaacactaat cacaaactga atgacttgac ttcaaaagca 6120
acaaccttaa aggccgtcat ttcattagta ttcctcattc tgcatcctgg cttgaaaaac 6180
agctctgttg aatcacagta tcagtatttt cacacgtaag cacattcggg ccatttccgt 6240
ggtttctcat gagctgtgtt cacagacctc agcagggcat cgcatggacc gcaggagggc 6300
agattcggac cactaggcct gaaatgacat ttcactaaaa gtctccaaaa catttctaag 6360
actactaagg ccttttatgt aatttcttta aatgtgtatt tcttaagaat tcaaatttgt 6420
aataaaacta tttgtataaa aattaagctt ttattaattt gttgctagta ttgccacaga 6480
cgcattaaaa gaaacttact gcacaagctg ctaataaatt tgtaagcttt gcatacctta 6540
6540
<210> 193
<211> 8455
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(8455)
<223> COL5A1 mRNA
<400> 193
ccgcactctc cgtccccgcg gctggcgcag gacctcactc gagcggagcg cccacgggga 60
gcgggtcgcg gggcggcggc ggcgaggagg aggcgagaag gagttggagg aggaggagga 120
ggaggcgagg gcgagctagc ccagcggggt cccggccgcc ccgcgggcca aagtcgagcc 180
ctcccgcccg tgggcgagcg cgccagccgc cccttccaga acagccgccg ccacaaagaa 240
gaacgggggg tgccgaggtc cccatgacct cctaaagtgg tgcggtccct gctgagtgcg 300
ctgcccgggc cgtgacccgc gcccctgtgc gtccccgcgc gcctccgagc gcccctgtgc 360
gccccggccc gcgccccgcc ggcatggacg tccatacccg ctggaaagcg cgcagcgcgc 420
tccgcccggg cgccccgctg ctgcccccgc tgctgctgct gctgctgtgg gcgccgcctc 480
cgagccgcgc agctcagcca gcagatctcc tgaaggttct agattttcac aacttgcctg 540
atggaataac aaagacaaca ggcttttgcg ccacgcggcg atcttccaaa ggcccggatg 600
tcgcttacag agtcaccaaa gacgcgcagc tcagcgcacc caccaagcag ctgtaccctg 660
cgtctgcatt tcccgaggac ttctccatcc taacaactgt gaaagccaag aaaggcagcc 720
aggccttcct ggtctccatc tacaacgagc agggtatcca gcagattggg ctggagctgg 780
gccgctctcc cgtcttcctc tacgaggacc acacggggaa gcctggcccg gaagactacc 840
ccctcttccg gggcatcaac ctgtcagatg gcaagtggca cagaattgct ctcagcgtcc 900
acaagaaaaa tgtcaccttg atcctcgact gtaaaaagaa gaccaccaaa ttcctcgacc 960
gcagcgacca ccccatgatc gacatcaatg gcatcatcgt gtttggcacc cggatcctgg 1020
atgaggaggt gtttgagggt gacatccagc agctgctctt tgtctcggac caccgggcag 1080
cttatgatta ctgtgagcac tacagccctg actgtgacac cgcagtacct gacaccccac 1140
agtcgcagga ccccaatcca gatgaatatt acacggaagg agacggcgag ggtgagacct 1200
attactacga atacccctac tacgaagacc ccgaagacct agggaaggag cccaccccca 1260
gcaagaagcc cgtggaagct gccaaagaaa ccacagaggt ccccgaggag ctgaccccga 1320
cccccacgga agctgctccc atgcctgaaa ccagtgaagg ggctgggaag gaagaggacg 1380
tcggcatcgg ggactatgac tacgtgccca gtgaggacta ctacacgccc tcaccgtatg 1440
atgacctcac ctatggcgag ggggaggaga accccgacca gcccacagac ccaggcgctg 1500
gggccgaaat tcccaccagc accgccgaca cctccaactc ctccaatcca gctccgcctc 1560
caggggaagg tgcggatgac ttggaggggg agttcactga ggaaacgatc cggaaccttg 1620
acgagaacta ctacgacccc tactacgacc ccaccagctc cccgtcggag atcgggccgg 1680
gaatgccggc gaaccaggat accatctatg aagggattgg aggacctcgg ggcgagaaag 1740
gccaaaaggg agaaccagcg attatcgagc cgggcatgct catcgagggc ccgcctggcc 1800
cagaaggccc cgcgggtctt cccggacctc caggaaccat gggtcccact ggccaagtcg 1860
gggaccctgg agaaaggggc ccccctggac gcccaggcct tcctggggcc gatggcctgc 1920
ccggtcctcc aggaaccatg ctcatgctgc ccttccggtt tggaggtggc ggcgatgcgg 1980
gctccaaagg ccccatggtc tcagcccagg agtcccaggc gcaagccatt ctccagcagg 2040
ccaggttggc actgagggga ccagctggcc cgatgggtct cacagggaga cctggccctg 2100
tgggtccccc tgggagcgga ggtttgaagg gcgagccggg agacgtgggg cctcagggtc 2160
ctcgaggtgt gcaaggcccg cctggtccgg ccgggaagcc cggaagacgg ggtcgggctg 2220
ggagtgatgg agccagagga atgcctggac aaactggccc caagggtgac cggggtttcg 2280
acggcctggc tgggttgcca ggcgagaagg gccacagggg tgaccctggt ccttccggcc 2340
caccaggacc tccgggagac gatggagaaa ggggtgacga cggagaagtt gggcccaggg 2400
ggctgcctgg ggagcccggg ccacgtggtc tgcttgggcc gaaggggccc ccaggtcctc 2460
ccggacctcc cggtgtcacg ggtatggacg gccagccggg gccaaaagga aatgtgggtc 2520
cccagggaga gcctggcccc ccaggacagc agggtaatcc aggcgcccag ggtcttccag 2580
gcccccaggg tgcaattggt cctccaggag aaaagggtcc cttggggaaa ccaggccttc 2640
caggaatgcc cggtgctgac ggacccccgg gacaccctgg caaagaaggc cctccaggag 2700
agaaaggagg tcagggtcca cctggccccc agggtccgat tggctaccca ggtcctcgag 2760
gagtcaaggg ggccgatggc atccgtggtc tgaagggcac aaagggcgag aagggtgaag 2820
acggctttcc tgggtttaaa ggagacatgg gcatcaaggg tgatcggggg gagatcggcc 2880
cacccggtcc caggggagaa gatggccctg aaggcccaaa gggtcgcgga ggtcccaatg 2940
gtgaccccgg tcctctggga ccccctgggg agaagggaaa actcggagtc ccagggttac 3000
cagggtatcc aggaagacaa ggaccaaagg gctctattgg attccctgga tttcctggcg 3060
ccaatggaga gaagggcggc agggggaccc ctggaaagcc aggaccgcgg gggcagcgag 3120
gcccaacggg tccgaggggt gaaagaggcc cccggggcat cactgggaag cctggcccca 3180
agggcaactc cggaggtgac ggcccagctg gccctcctgg tgaacgggga cccaatggac 3240
cccaaggacc cacaggattt cctggaccaa agggcccccc tggccctcca ggcaaggatg 3300
gactcccagg acaccctgga cagagaggcg agactggttt ccaaggcaag accggccctc 3360
caggcccccc cggcgtggtc ggccctcagg gtcccacggg agaaacgggc ccaatgggtg 3420
agcgtggcca ccctgggccc cctggacccc ccggtgaaca ggggcttccg ggccttgctg 3480
gaaaagaagg gacgaagggt gacccaggcc ctgcaggcct ccctgggaaa gatggccctc 3540
caggattacg tggtttccct ggggaccgag ggcttcctgg tccagtggga gctcttggac 3600
tgaaaggcaa tgaagggccc cctggcccac caggccctgc gggatctcca ggggagagag 3660
gtccagctgg agccgctggg cccatcggaa ttccagggag acctgggccc cagggacccc 3720
cagggccggc aggagagaaa ggggctcctg gcgagaaagg cccacaaggc ccagctggcc 3780
gagacggtct ccaggggcct gtggggctcc cgggtccagc tggccctgtg ggtccccctg 3840
gagaagacgg agataaggga gagatcgggg agccggggca gaaaggaagc aagggggaca 3900
aaggagaaca gggtcctcct gggcctacag gtcctcaagg ccccatcgga cagccaggcc 3960
cctctggagc tgacggcgag ccggggcctc ggggccagca gggccttttc gggcagaaag 4020
gtgatgaagg tcccagaggc tttcctggac cccctgggcc agtggggctg cagggtttgc 4080
caggacctcc aggcgagaag ggtgagacag gagacgtggg ccagatgggc cccccgggtc 4140
cccctggccc ccgaggaccc tccggagctc caggtgctga tggcccacaa ggtcccccag 4200
gtggaatagg aaaccctggt gcagtgggag agaagggcga gcctggcgaa gcaggtgagc 4260
ctggccttcc gggagaaggc ggccccccgg gacccaaagg agaaagggga gagaagggcg 4320
agtcaggccc ttcaggtgct gccggacccc ctggacccaa aggccctccc ggagatgatg 4380
gtcccaaagg cagccctggc ccagtgggtt ttcctggaga tcctggcccc cccggagagc 4440
ctggccccgc gggtcaagat ggtccccctg gtgacaaagg agatgatggt gaacccgggc 4500
agacgggatc ccccggccct actggtgaac caggtccatc ggggcctcca ggaaaaaggg 4560
gtcccccagg ccccgcaggc cccgaaggca gacagggaga gaaaggggcc aagggagaag 4620
ccggcttgga aggccctcct gggaagactg gccccatcgg cccccagggg gcccctggga 4680
agcccggacc ggatggcctt cgagggatcc ctggccctgt gggagaacaa ggtctcccag 4740
gatccccagg cccggacggt ccccccggcc ccatgggtcc cccaggactt cccggcctca 4800
aaggagattc tggtcccaaa ggtgaaaagg gtcatccagg cctgatcggg ctcatcggtc 4860
ctccgggtga acagggtgag aagggcgacc gtggtctccc tggcccccag ggctcctccg 4920
gtcctaaggg agaacagggt atcactggtc cttctggccc gattgggcct cctgggcccc 4980
ctggcctgcc gggtccgcct ggtccaaaag gtgctaaggg ctcctcgggt ccaactggcc 5040
cgaagggtga ggcaggccac ccaggacccc caggcccccc gggccccccg ggagaggtca 5100
tccagcccct gccaatccag gcatccagga cgcggcggaa catcgacgcc agccagctgc 5160
tggacgacgg gaatggcgag aactacgtgg actacgcgga cggcatggaa gagatcttcg 5220
gctctctcaa ctctctgaag ctggagattg agcagatgaa acggcccctg ggcacgcagc 5280
agaaccccgc ccgcacctgc aaggacctgc agctctgcca ccccgacttc ccagatggtg 5340
aatactgggt cgatcctaac caaggatgct ccagggattc cttcaaggtt tactgcaact 5400
tcacagccgg ggggtcgaca tgcgtcttcc ctgacaagaa gtccgaaggg gccagaatca 5460
cttcttggcc caaagaaaac ccgggctcct ggttcagtga attcaagcgt gggaaactgc 5520
tctcctatgt ggacgccgag ggcaaccctg tgggtgtggt acagatgacc ttcctgcggc 5580
tgctgagcgc ctctgcccac cagaacgtca cctaccactg ctaccagtca gtggcctggc 5640
aggacgcagc cacgggcagc tacgacaagg ccctccgctt cctgggctcc aacgacgagg 5700
agatgtccta tgacaacaac ccctacatcc gcgccctggt ggacggctgt gctaccaaga 5760
aaggctacca gaagacggtt ctggagatcg acacccccaa agtggagcag gtgcccatcg 5820
tggacatcat gttcaatgac ttcggtgaag cgtcacagaa atttggattt gaagtggggc 5880
cggcttgctt catgggctag gagccgccga gcccgggctc ccgagagcaa cctcgtgacc 5940
tcagcatgcc attcgttcgt gagtgtcccg tgcacgtcct gaccctggac agtgaaggct 6000
tctccctccc ctcccacctg acttcatcta cgcctcggca ccacggggtg tgggacccca 6060
gcccggagag aacagaggga aggagccgcg cccccacctg gagctgaatc acatgaccta 6120
gctgcacccc agcgcctggg cccgccccac gctctgtcca cacccacgcg ccccgggagc 6180
ggggccatgc ctccagcccc ccagctcgcc cgacccatcc tgttcgtgaa taggtctcag 6240
gggttggggg agggactgcc agatttggac actatatttt tttctaaatt caacttgaag 6300
atgtgtattt cccctgacct tcaaaaaatg ttccaaggta agcctcgtaa aggtcatccc 6360
accatcacca aagcctccgt ttttaacaac ctccaacacg atccatttag aggccaaatg 6420
tcattctgca ggtgccttcc cgatggatta aaggtgctta tgtttttgtg agttttaagt 6480
aaatatttgt attgtattgt tataaatgtt aagtgtgcct ggctttcaat catgcacgga 6540
aacccagtct cagtcccacg gacagaatgg gcgaggcatg gattctgggt tgcagtaccg 6600
ttctgattag aaataggaag tctccccacc cccgccctgg ccaagaacgt gcaataaatt 6660
ggaagtttgc cccggggcag caagaattta tgctgccatt gaaaagcagg taccagtgcc 6720
ccttttcaga cagtttttga ttcgctctag actttttttt tttttaatag ggaaaaaatt 6780
tgataatttt cttttttcta catgcactta agactaaaac acaggtttgg attaatttta 6840
tttgcttcct ttttccgctt ttcttcccgc agagcctgat gggagaatgt ccagggcagg 6900
gaaaccacat tttttgtagg tgataactca atgaaaattg gtgcttattt tttacacttc 6960
tctcttgtgg ctctcttgtg gtgctatcta tctgttttaa ggtctccttg aaggcgcact 7020
ggggaccctg gccatgcctc gttctccctg ctttctttat cctgttattg cctccacagt 7080
ctgttgccaa ggactctaag atcaatgcac gtcactttcc tttccactgg gcaggatagc 7140
caagcacact ccctcctgcg ctctcccgcc ccggtgcgtc cactcccgag ggctgttatg 7200
aggactgggt tgtgcctact tgatttgaaa acacacacaa gcaataaaaa gcctcttcct 7260
gcattgtctg tggtgtgacc atagcagatt atatttggtt cctgaatgtt tgtggtgcta 7320
atttctgtgt ttgttccaag ccgttcagtc atgccatgcg ctgcctcggt agatggagta 7380
atgtacaatg aactccatga gtctctccag ggctgcctgc agcacgtctt ttccaagtag 7440
cctatttgga ttcccatctc aaatgtcctg gatgcgagcg tcagcggctc cagagctcgg 7500
ggcgggtgag gtcccctttg gggaaccctt tcctggccat cgaggtcggg gggctgccgt 7560
ctgtgggcag gaggacccga ggggcagcca ggaaaggcga tctcttcact gtgaaaagtt 7620
gcccgggtgc agcgcctttt ccttctacca tgggaaatgc aggctgggcc cttggggtga 7680
gcctgcgggg ctctggtgct gtccccgacc cccaccacca ccagaatgca gttccagctt 7740
aggaagccac aaacaagcca cccaggagga acaaaacacc gccagcgtgg attttccaaa 7800
tttccctgga aagtaagtct cgctcttgcc aaagaaaagt ctggcttgga gagtctctgg 7860
agcccaggat gccagcatgt gccaatgact gtcaccttca tctcttcaaa agaaaagcca 7920
tagccgagga ctgtcccgcg acccccgtgg actgcgtcta ggtcatgtga ttctgttttc 7980
atttctcatc ccatccaatt tgtccttttc tcctgtcatt ttcttcctct gtggtccctt 8040
caaagttgtt ataatttgta ctgaacttca aaatgtgtcc cgttctcccc agaccactct 8100
agccacagta tattgcaata aaattacttc ttatatttgc agaaattctt ttggtgtaat 8160
tttatttttt cctctcaata tatataattg gacaaacgct ggcaaaaaga aaaaaatggt 8220
aagcaaaaaa cccaagataa agtttcgagg acatcaggcc ttttgaaata caatgtcaaa 8280
tgacacattg tacggtttca aaaaatccgc tagacatgtc ataagtttta actgtaatgc 8340
ccaggaaagg atatcttaaa atattctaaa cttgtgtaac aaaggaataa ttaactgtaa 8400
tagtttttca ataaatcgag ttgggtgttt ccaccgtaaa aaaaaaaaaa aaaaa 8455
<210> 194
<211> 6829
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6829)
<223> COL5A2 mRNA
<400> 194
gcagactgtg ctggagctgg tgctgaaaaa gggggtttgc agaggctgcc ctggggctgg 60
tgctgaaaga agagcccaca gctgacttca tggtgctaca ataacctcag aatctacttt 120
tcactctcag gagaacccac atgtctaata tttagacatg atggcaaact gggcggaagc 180
aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga 240
agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta 300
cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc 360
cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc 420
ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata ccaattttgg 480
tagaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg 540
tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc 600
aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg 660
tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag 720
caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt 780
aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg 840
acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat 900
gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga 960
acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg 1020
atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga 1080
aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc 1140
aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg 1200
gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat 1260
gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga 1320
agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg 1380
gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc 1440
tggtgccaaa ggcccaacgg gctctccagg tacctctggt cctcctggct cagcagggcc 1500
tcctggatct ccaggacctc agggtagcac tggtcctcag ggaattcgag gccaaccggg 1560
tgatccagga gttccaggtt tcaaaggaga agctggccca aaaggggaac cagggccaca 1620
tggtattcag ggtccgatag gcccacccgg tgaagaaggc aaaagaggtc ccagaggtga 1680
cccaggaaca gttggtcctc cagggccagt gggagaaagg ggtgctcctg gcaatcgtgg 1740
ttttccaggc tctgatggtt tacctgggcc aaagggtgct caaggagaac ggggtcctgt 1800
aggttcttca ggacccaaag gaagccaggg ggatccagga cgtccagggg aacctgggct 1860
tccaggtgct cggggtttga caggaaatcc tggtgttcaa ggtcctgaag gaaaacttgg 1920
acctttgggt gcgccagggg aagatggccg tccaggtcct ccaggctcca taggaatcag 1980
agggcagccc gggagcatgg gccttccagg ccccaaaggt agcagtggtg accctgggaa 2040
acctggagaa gcaggaaatg ctggagttcc tgggcagagg ggagctcctg gaaaagatgg 2100
tgaagttggt ccttctggtc ctgtgggccc gccgggtcta gctggtgaaa gaggagaaca 2160
aggacctcca ggccccacag gttttcaggg gcttcctggt cctccagggc ctcctggaga 2220
aggtggaaaa ccaggtgatc aaggtgttcc tggagatccc ggagcagttg gcccgttagg 2280
acctagagga gaacgaggaa atcctgggga aagaggagaa cctgggataa ctggactccc 2340
tggtgagaag ggaatggctg gaggacatgg tcctgatggc ccaaaaggca gtccaggtcc 2400
atctgggacc cctggagata caggcccacc aggtcttcaa ggtatgccgg gagaaagagg 2460
aattgcagga actcctggcc ccaagggtga cagaggtggc ataggagaaa aaggtgctga 2520
aggcacagct ggaaatgatg gtgcaagagg tcttccaggt cctttgggcc ctccaggtcc 2580
ggcaggtcct actggagaaa agggtgaacc tggtcctcga ggtttagttg gccctcctgg 2640
ctcccggggc aatcctggtt ctcgaggtga aaatgggcca actggagctg ttggttttgc 2700
cggaccccag ggtcctgacg gacagcctgg agtaaaaggt gaacctggag agccaggaca 2760
gaagggagat gctggttctc ctggaccaca aggtttagca ggatcccctg gccctcatgg 2820
tcctaatggt gttcctggac taaaaggtgg tcgaggaacc caaggtccgc ctggtgctac 2880
aggatttcct ggttctgcgg gcagagttgg acctccaggc cctgctggag ctccaggacc 2940
tgcgggaccc ctaggggaac ccgggaagga gggacctcca ggtcttcgtg gggaccctgg 3000
ctctcatggg cgtgtgggag atcgaggacc agctggcccc cctggtggcc caggagacaa 3060
aggggaccca ggagaagatg ggcaacctgg tccagatggc ccccctggtc cagctggaac 3120
gaccgggcag agaggaattg ttggcatgcc tgggcaacgt ggagagagag gcatgcccgg 3180
cctaccaggc ccagcgggaa caccaggaaa agtaggacca actggtgcaa caggagataa 3240
aggtccacct ggacctgtgg ggcccccagg ctccaatggt cctgtagggg aacctggacc 3300
agaaggtcca gctggcaatg atggtacccc aggacgggat ggtgctgttg gagaacgtgg 3360
tgatcgtgga gaccctgggc ctgcaggtct gccaggctct cagggtgccc ctggaactcc 3420
tggccctgtg ggtgctccag gagatgcagg acaaagagga gatccgggtt ctcggggtcc 3480
tataggacca cctggtcgag ctgggaaacg tggattacct ggaccccaag gacctcgtgg 3540
tgacaaaggt gatcatggag accgaggtga cagaggtcag aagggccaca gaggctttac 3600
tggtcttcag ggtcttcctg gccctcctgg tccaaatggt gaacaaggaa gtgctggaat 3660
ccctggacca tttggcccaa gaggtcctcc aggcccagtt ggtccttcag gtaaagaagg 3720
aaaccctggg ccacttgggc caattggacc tccaggtgta cgaggcagtg taggagaagc 3780
aggacctgag ggccctcctg gtgagcctgg cccacctggc cctccgggtc cccctggcca 3840
ccttacagct gctcttgggg atatcatggg gcactatgat gaaagcatgc cagatccact 3900
tcctgagttt actgaagatc aggcggctcc tgatgacaaa aacaaaacgg acccaggggt 3960
tcatgctacc ctgaagtcac tcagtagtca gattgaaacc atgcgcagcc ccgatggctc 4020
gaaaaagcac ccagcccgca cgtgtgatga cctaaagctt tgccattccg caaagcagag 4080
tggtgaatac tggattgatc ctaaccaagg atctgttgaa gatgcaatca aagtttactg 4140
caacatggaa acaggagaaa catgtatttc agcaaaccca tccagtgtac cacgtaaaac 4200
ctggtgggcc agtaaatctc ctgacaataa acctgtttgg tatggtcttg atatgaacag 4260
agggtctcag ttcgcttatg gagaccacca atcacctaat acagccatta ctcagatgac 4320
ttttttgcgc cttttatcaa aagaagcctc ccagaacatc acttacatct gtaaaaacag 4380
tgtaggatac atggacgatc aagctaagaa cctcaaaaaa gctgtggttc tcaaaggggc 4440
aaatgactta gatatcaaag cagagggaaa tattagattc cggtatatcg ttcttcaaga 4500
cacttgctct aagcggaatg gaaatgtggg caagactgtc tttgaatata gaacacagaa 4560
tgtggcacgc ttgcccatca tagatcttgc tcctgtggat gttggcggca cagaccagga 4620
attcggcgtt gaaattgggc cagtttgttt tgtgtaaagt aagccaagac acatcgacaa 4680
tgagcaccac catcaatgac caccgccatt cacaagaact ttgactgttt gaagttgatc 4740
ctgagactct tgaagtaatg gctgatcctg catcagcatt gtatatatgg tcttaagtgc 4800
ctggcctcct tatccttcag aatatttatt ttacttacaa tcctcaagtt ttaattgatt 4860
ttaaatattt ttcaatacaa cagtttaggt ttaagatgac caatgacaat gaccaccttt 4920
gcagaaagta aactgattga ataaataaat ctccgttttc ttcaatttat ttcagtgtaa 4980
tgaaaaagtt gcttagtatt tatgaggaaa ttcttcttcc tggcaggtag cttaaagagt 5040
ggggtatata gagccacaac acatgtttat tttgcttggc tgcagttgaa aaatagaaat 5100
tagtgccctt ttgtgacctc tcattccaag attgtcaatt aaaaatgagt ttaaaatgtt 5160
taacttgtga tcgagaccta catgcatgtc ttgatattgt gtaactataa tagagactct 5220
ttaaggagaa tcttaaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat 5280
agtatatatt cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt 5340
tgtaaaagac tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc 5400
ttgatcaatc tatcaatatt gatagaagtc acactagtat ataccattta atacatttac 5460
actttcttat ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca 5520
tatgtccaag gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc 5580
tataatgaag aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg 5640
attggaatta gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta 5700
gcatgagcta cctcatctct agaagctggg atggacttac tattcttgtt tatattttag 5760
atactgaaag gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa 5820
aggtattatt atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa 5880
aataaagatg gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg 5940
aaagaaagag catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat 6000
gctttgtaat acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata 6060
cttttttttt cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac 6120
agctgggacc atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa 6180
gcatcaaatt aaatgcacgc ttttgtcatg tcagtggttt ttgttttgtg aaattccttt 6240
gaccatatta gatctatttc atttccaata gtgaaaagga gatgtggtgg tatactttgt 6300
ttgccatttg tttaaaagat acaacggata ccttctatca tgtatgtact ggcttataaa 6360
tgaaaatcta tctacaacat tacccacaaa ggcaacatga caccaattat cactgcctct 6420
gcccttaaaa atgtcagagt agtattattg ataaaaaggg caagcaatag atttttcatg 6480
actgaataaa ctgtaataat aaaacatatg tctcaaagtg tatcacatat gaatttagcc 6540
taattgtttt cagtttcatt ctcaatattt agtttacaac atcattttcc cctaaactgg 6600
ttatattttg acctgtatat cttaaatttg agtatttata tgcctaaata catgtgtgag 6660
ttttgtttga cttccaagtc caaactataa gattatataa gttcatatag atgaatcaga 6720
aatatgtggt aatactatta agtcacaaac actaacaatt tccaactata gaaataacag 6780
ttcttatttg gattttggga atgctaccaa taaaagcctg cccagacca 6829
<210> 195
<211> 1769
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1769)
<223> CSF3 mRNA
<400> 195
agtcgtggcc ccaggtaatt tcctcccagg cctccatggg gttatgtata aaggcccccc 60
tagagctggg ccccaaaaca gcccggagcc tgcagcccag ccccacccag acccatggct 120
ggacctgcca cccagagccc catgaagctg atgggtgagt gtcttggccc aggatgggag 180
agccgcctgc cctggcatgg gagggaggct ggtgtgacag aggggctggg gatccccgtt 240
ctgggaatgg ggattaaagg cacccagtgt ccccgagagg gcctcaggtg gtagggaaca 300
gcatgtctcc tgagcccgct ctgtccccag ccctgcagct gctgctgtgg cacagtgcac 360
tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc cagagcttcc 420
tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg ctccaggaga 480
agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc ggacactctc 540
tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag ctggcaggct 600
gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag gccctggaag 660
ggatctcccc cgagttgggt cccaccttgg acacactgca gctggacgtc gccgactttg 720
ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg cagcccaccc 780
agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg gtcctggttg 840
cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac cttgcccagc 900
cctgagccaa gccctcccca tcccatgtat ttatctctat ttaatattta tgtctattta 960
agcctcatat ttaaagacag ggaagagcag aacggagccc caggcctctg tgtccttccc 1020
tgcatttctg agtttcattc tcctgcctgt agcagtgaga aaaagctcct gtcctcccat 1080
cccctggact gggaggtaga taggtaaata ccaagtattt attactatga ctgctcccca 1140
gccctggctc tgcaatgggc actgggatga gccgctgtga gcccctggtc ctgagggtcc 1200
ccacctggga cccttgagag tatcaggtct cccacgtggg agacaagaaa tccctgttta 1260
atatttaaac agcagtgttc cccatctggg tccttgcacc cctcactctg gcctcagccg 1320
actgcacagc ggcccctgca tccccttggc tgtgaggccc ctggacaagc agaggtggcc 1380
agagctggga ggcatggccc tggggtccca cgaatttgct ggggaatctc gtttttcttc 1440
ttaagacttt tgggacatgg tttgactccc gaacatcacc gacgcgtctc ctgtttttct 1500
gggtggcctc gggacacctg ccctgccccc acgagggtca ggactgtgac tctttttagg 1560
gccaggcagg tgcctggaca tttgccttgc tggacgggga ctggggatgt gggagggagc 1620
agacaggagg aatcatgtca ggcctgtgtg tgaaaggaag ctccactgtc accctccacc 1680
tcttcacccc ccactcacca gtgtcccctc cactgtcaca ttgtaactga acttcaggat 1740
aataaagtgt ttgcctccaa aaaaaaaaa 1769
<210> 196
<211> 2358
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2358)
<223> CTCF mRNA
<400> 196
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca 60
gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc 120
ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc 180
cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg 240
ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc 300
cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg 360
acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg 420
acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga 480
tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca 540
gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg 600
gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga 660
ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc 720
aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc 780
caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga 840
cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga 900
agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga 960
agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg 1020
gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat 1080
gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg 1140
tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag 1200
acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc 1260
agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt 1320
ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa 1380
gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac 1440
actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat 1500
gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat 1560
cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat 1620
tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag 1680
ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat 1740
tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt 1800
ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg 1860
tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg 1920
tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct 1980
gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta 2040
tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga 2100
ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa 2160
tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc 2220
tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt 2280
gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta 2340
taaaaaaaaa aaaaaaaa 2358
<210> 197
<211> 3661
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3661)
<223> CTNNB1 mRNA
<400> 197
aagcctctcg gtctgtggca gcagcgttgg cccggccccg ggagcggaga gcgaggggag 60
gcggagacgg aggaaggtct gaggagcagc ttcagtcccc gccgagccgc caccgcaggt 120
cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta tttgaagtat 180
accatacaac tgttttgaaa atccagcgtg gacaatggct actcaagctg atttgatgga 240
gttggacatg gccatggaac cagacagaaa agcggctgtt agtcactggc agcaacagtc 300
ttacctggac tctggaatcc attctggtgc cactaccaca gctccttctc tgagtggtaa 360
aggcaatcct gaggaagagg atgtggatac ctcccaagtc ctgtatgagt gggaacaggg 420
attttctcag tccttcactc aagaacaagt agctgatatt gatggacagt atgcaatgac 480
tcgagctcag agggtacgag ctgctatgtt ccctgagaca ttagatgagg gcatgcagat 540
cccatctaca cagtttgatg ctgctcatcc cactaatgtc cagcgtttgg ctgaaccatc 600
acagatgctg aaacatgcag ttgtaaactt gattaactat caagatgatg cagaacttgc 660
cacacgtgca atccctgaac tgacaaaact gctaaatgac gaggaccagg tggtggttaa 720
taaggctgca gttatggtcc atcagctttc taaaaaggaa gcttccagac acgctatcat 780
gcgttctcct cagatggtgt ctgctattgt acgtaccatg cagaatacaa atgatgtaga 840
aacagctcgt tgtaccgctg ggaccttgca taacctttcc catcatcgtg agggcttact 900
ggccatcttt aagtctggag gcattcctgc cctggtgaaa atgcttggtt caccagtgga 960
ttctgtgttg ttttatgcca ttacaactct ccacaacctt ttattacatc aagaaggagc 1020
taaaatggca gtgcgtttag ctggtgggct gcagaaaatg gttgccttgc tcaacaaaac 1080
aaatgttaaa ttcttggcta ttacgacaga ctgccttcaa attttagctt atggcaacca 1140
agaaagcaag ctcatcatac tggctagtgg tggaccccaa gctttagtaa atataatgag 1200
gacctatact tacgaaaaac tactgtggac cacaagcaga gtgctgaagg tgctatctgt 1260
ctgctctagt aataagccgg ctattgtaga agctggtgga atgcaagctt taggacttca 1320
cctgacagat ccaagtcaac gtcttgttca gaactgtctt tggactctca ggaatctttc 1380
agatgctgca actaaacagg aagggatgga aggtctcctt gggactcttg ttcagcttct 1440
gggttcagat gatataaatg tggtcacctg tgcagctgga attctttcta acctcacttg 1500
caataattat aagaacaaga tgatggtctg ccaagtgggt ggtatagagg ctcttgtgcg 1560
tactgtcctt cgggctggtg acagggaaga catcactgag cctgccatct gtgctcttcg 1620
tcatctgacc agccgacacc aagaagcaga gatggcccag aatgcagttc gccttcacta 1680
tggactacca gttgtggtta agctcttaca cccaccatcc cactggcctc tgataaaggc 1740
tactgttgga ttgattcgaa atcttgccct ttgtcccgca aatcatgcac ctttgcgtga 1800
gcagggtgcc attccacgac tagttcagtt gcttgttcgt gcacatcagg atacccagcg 1860
ccgtacgtcc atgggtggga cacagcagca atttgtggag ggggtccgca tggaagaaat 1920
agttgaaggt tgtaccggag cccttcacat cctagctcgg gatgttcaca accgaattgt 1980
tatcagagga ctaaatacca ttccattgtt tgtgcagctg ctttattctc ccattgaaaa 2040
catccaaaga gtagctgcag gggtcctctg tgaacttgct caggacaagg aagctgcaga 2100
agctattgaa gctgagggag ccacagctcc tctgacagag ttacttcact ctaggaatga 2160
aggtgtggcg acatatgcag ctgctgtttt gttccgaatg tctgaggaca agccacaaga 2220
ttacaagaaa cggctttcag ttgagctgac cagctctctc ttcagaacag agccaatggc 2280
ttggaatgag actgctgatc ttggacttga tattggtgcc cagggagaac cccttggata 2340
tcgccaggat gatcctagct atcgttcttt tcactctggt ggatatggcc aggatgcctt 2400
gggtatggac cccatgatgg aacatgagat gggtggccac caccctggtg ctgactatcc 2460
agttgatggg ctgccagatc tggggcatgc ccaggacctc atggatgggc tgcctccagg 2520
tgacagcaat cagctggcct ggtttgatac tgacctgtaa atcatccttt aggtaagaag 2580
ttttaaaaag ccagtttggg taaaatactt ttactctgcc tacagaactt cagaaagact 2640
tggttggtag ggtgggagtg gtttaggcta tttgtaaatc tgccacaaaa acaggtatat 2700
actttgaaag gagatgtctt ggaacattgg aatgttctca gatttctggt tgttatgtga 2760
tcatgtgtgg aagttattaa ctttaatgtt ttttgccaca gcttttgcaa cttaatactc 2820
aaatgagtaa catttgctgt tttaaacatt aatagcagcc tttctctctt tatacagctg 2880
tattgtctga acttgcattg tgattggcct gtagagttgc tgagagggct cgaggggtgg 2940
gctggtatct cagaaagtgc ctgacacact aaccaagctg agtttcctat gggaacaatt 3000
gaagtaaact ttttgttctg gtcctttttg gtcgaggagt aacaatacaa atggattttg 3060
ggagtgactc aagaagtgaa gaatgcacaa gaatggatca caagatggaa tttatcaaac 3120
cctagccttg cttgttaaat tttttttttt ttttttttaa gaatatctgt aatggtactg 3180
actttgcttg ctttgaagta gctctttttt tttttttttt tttttttttg cagtaactgt 3240
tttttaagtc tctcgtagtg ttaagttata gtgaatactg ctacagcaat ttctaatttt 3300
taagaattga gtaatggtgt agaacactaa ttcataatca ctctaattaa ttgtaatctg 3360
aataaagtgt aacaattgtg tagccttttt gtataaaata gacaaataga aaatggtcca 3420
attagtttcc tttttaatat gcttaaaata agcaggtgga tctatttcat gtttttgatc 3480
aaaaactatt tgggatatgt atgggtaggg taaatcagta agaggtgtta tttggaacct 3540
tgttttggac agtttaccag ttgcctttta tcccaaagtt gttgtaacct gctgtgatac 3600
gatgcttcaa gagaaaatgc ggttataaaa aatggttcag aattaaactt ttaattcatt 3660
c 3661
<210> 198
<211> 1629
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1629)
<223> CTSK mRNA
<400> 198
acactttgct gccgaaacga agccagacaa cagatttcca tcagcaggat gtgggggctc 60
aaggttctgc tgctacctgt ggtgagcttt gctctgtacc ctgaggagat actggacacc 120
cactgggagc tatggaagaa gacccacagg aagcaatata acaacaaggt ggatgaaatc 180
tctcggcgtt taatttggga aaaaaacctg aagtatattt ccatccataa ccttgaggct 240
tctcttggtg tccatacata tgaactggct atgaaccacc tgggggacat gaccagtgaa 300
gaggtggttc agaagatgac tggactcaaa gtacccctgt ctcattcccg cagtaatgac 360
accctttata tcccagaatg ggaaggtaga gccccagact ctgtcgacta tcgaaagaaa 420
ggatatgtta ctcctgtcaa aaatcagggt cagtgtggtt cctgttgggc ttttagctct 480
gtgggtgccc tggagggcca actcaagaag aaaactggca aactcttaaa tctgagtccc 540
cagaacctag tggattgtgt gtctgagaat gatggctgtg gagggggcta catgaccaat 600
gccttccaat atgtgcagaa gaaccggggt attgactctg aagatgccta cccatatgtg 660
ggacaggaag agagttgtat gtacaaccca acaggcaagg cagctaaatg cagagggtac 720
agagagatcc ccgaggggaa tgagaaagcc ctgaagaggg cagtggcccg agtgggacct 780
gtctctgtgg ccattgatgc aagcctgacc tccttccagt tttacagcaa aggtgtgtat 840
tatgatgaaa gctgcaatag cgataatctg aaccatgcag ttttggcagt gggatatgga 900
atccagaagg gaaacaagca ctggataatt aaaaacagct ggggagaaaa ctggggaaac 960
aaaggatata tcctcatggc tcgaaataag aacaacgcct gtggcattgc caacctggcc 1020
agcttcccca agatgtgact ccagccagcc aaatccatcc tgctcttcca tttcttccac 1080
gatggtgcag tgtaacgatg cactttggaa gggagttggt gtgctatttt tgaagcagat 1140
gtggtgatac tgagattgtc tgttcagttt ccccatttgt ttgtgcttca aatgatcctt 1200
cctactttgc ttctctccac ccatgacctt tttcactgtg gccatcagga ctttccctga 1260
cagctgtgta ctcttaggct aagagatgtg actacagcct gcccctgact gtgttgtccc 1320
agggctgatg ctgtacaggt acaggctgga gattttcaca taggttagat tctcattcac 1380
gggactagtt agctttaagc accctagagg actagggtaa tctgacttct cacttcctaa 1440
gttcccttct atatcctcaa ggtagaaatg tctatgtttt ctactccaat tcataaatct 1500
attcataagt ctttggtaca agtttacatg ataaaaagaa atgtgatttg tcttcccttc 1560
tttgcacttt tgaaataaag tatttatctc ctgtctacag tttaataaat agcatctagt 1620
acacattca 1629
<210> 199
<211> 1184
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1184)
<223> CXCL1 mRNA
<400> 199
cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca 60
gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg 120
gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg 180
agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc 240
caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt 300
catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa 360
gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa 420
gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag 480
agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga 540
agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg 600
taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt 660
ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg 720
ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc 780
actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg 840
gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga 900
aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt 960
ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt 1020
agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga 1080
atataaaaat aaagcactta tagaaaaaac tcgtttgatt tttgggggga aacaagggct 1140
acctttactg gaaaatctgg tgatttataa aaaaaaaaaa aaaa 1184
<210> 200
<211> 2436
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2436)
<223> CXCL5 mRNA
<400> 200
acagtgctcc ggatcctcca atcttcgctc ctccaatctc cgctcctcca cccagttcag 60
gaacccgcga ccgctcgcag cgctctcttg accactatga gcctcctgtc cagccgcgcg 120
gcccgtgtcc ccggtccttc gagctccttg tgcgcgctgt tggtgctgct gctgctgctg 180
acgcagccag ggcccatcgc cagcgctggt cctgccgctg ctgtgttgag agagctgcgt 240
tgcgtttgtt tacagaccac gcaaggagtt catcccaaaa tgatcagtaa tctgcaagtg 300
ttcgccatag gcccacagtg ctccaaggtg gaagtggtag cctccctgaa gaacgggaag 360
gaaatttgtc ttgatccaga agcccctttt ctaaagaaag tcatccagaa aattttggac 420
ggtggaaaca aggaaaactg attaagagaa atgagcacgc atggaaaagt ttcccagtct 480
tcagcagaga agttttctgg aggtctctga acccagggaa gacaagaagg aaagattttg 540
ttgttgtttg tttatttgtt tttccagtag ttagctttct tcctggattc ctcactttga 600
agagtgtgag gaaaacctat gtttgccgct taagctttca gctcagctaa tgaagtgttt 660
agcatagtac ctctgctatt tgctgttatt ttatctgcta tgctattgaa gttttggcaa 720
ttgactatag tgtgagccag gaatcactgg ctgttaatct ttcaaagtgt cttgaattgt 780
aggtgactat tatatttcca agaaatattc cttaagatat taactgagaa ggctgtggat 840
ttaatgtgga aatgatgttt cataagaatt ctgttgatgg aaatacactg ttatcttcac 900
ttttataaga aataggaaat attttaatgt ttcttgggga atatgttaga gaatttcctt 960
actcttgatt gtgggatact atttaattat ttcactttag aaagctgagt gtttcacacc 1020
ttatctatgt agaatatatt tccttattca gaatttctaa aagtttaagt tctatgaggg 1080
ctaatatctt atcttcctat aattttagac attctttatc tttttagtat ggcaaactgc 1140
catcatttac ttttaaactt tgattttata tgctatttat taagtatttt attaggagta 1200
ccataattct ggtagctaaa tatatatttt agatagatga agaagctaga aaacaggcaa 1260
attcctgact gctagtttat atagaaatgt attcttttag tttttaaagt aaaggcaaac 1320
ttaacaatga cttgtactct gaaagttttg gaaacgtatt caaacaattt gaatataaat 1380
ttatcattta gttataaaaa tatatagcga catcctcgag gccctagcat ttctccttgg 1440
ataggggacc agagagagct tggaatgtta aaaacaaaac aaaacaaaaa aaaacaagga 1500
gaagttgtcc aagggatgtc aattttttat ccctctgtat gggttagatt ttccaaaatc 1560
ataatttgaa gaaggccagc atttatggta gaatatataa ttatatataa ggtggccacg 1620
ctggggcaag ttccctcccc actcacagct ttggcccctt tcacagagta gaacctgggt 1680
tagaggattg cagaagacga gcgggagcgg ggagggcagg gaagatgcct gtcgggtttt 1740
tagcacagtt catttcactg ggattttgaa gcatttctgt ctgaatgtaa agcctgttct 1800
agtcctggtg ggacacactg gggttggggg tgggggaaga tgcggtaatg aaaccggtta 1860
gtcagtgttg tcttaatatc cttgataatg ctgtaaagtt tatttttaca aatatttctg 1920
tttaagctat ttcacctttg tttggaaatc cttccctttt aaagagaaaa tgtgacactt 1980
gtgaaaaggc ttgtaggaaa gctcctccct ttttttcttt aaacctttaa atgacaaacc 2040
taggtaatta atggttgtga atttctattt ttgctttgtt tttaatgaac atttgtcttt 2100
cagaatagga ttctgtgata atatttaaat ggcaaaaaca aaacataatt ttgtgcaatt 2160
aacaaagcta ctgcaagaaa aataaaacat ttcttggtaa aaacgtatgt atttatatat 2220
tatatattta tatataatat atattatata tttagcattg ctgagctttt tagatgccta 2280
ttgtgtatct tttaaaggtt ttgaccattt tgttatgagt aattacatat atattacatt 2340
cactatatta aaattgtact tttttactat gtgtctcatt ggttcatagt ctttattttg 2400
tcctttgaat aaacattaaa agatttctaa acttca 2436
<210> 201
<211> 1537
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1537)
<223> CXCL6 mRNA
<400> 201
caaagtgctc tgtatcctcc agtctccgcg cctccaccca gctcaggaac ccgcgaaccc 60
tctcttgacc actatgagcc tcccgtccag ccgcgcggcc cgtgtcccgg gtccttcggg 120
ctccttgtgc gcgctgctcg cgctgctgct cctgctgacg ccgccggggc ccctcgccag 180
cgctggtcct gtctctgctg tgctgacaga gctgcgttgc acttgtttac gcgttacgct 240
gagagtaaac cccaaaacga ttggtaaact gcaggtgttc cccgcaggcc cgcagtgctc 300
caaggtggaa gtggtagcct ccctgaagaa cgggaagcaa gtttgtctgg acccggaagc 360
cccttttcta aagaaagtca tccagaaaat tttggacagt ggaaacaaga aaaactgagt 420
aacaaaaaag accatgcatc ataaaattgc ccagtcttca gcggagcagt tttctggaga 480
tccctggacc cagtaagaat aagaaggaag ggttggtttt tttccatttt ctacatggat 540
tccctacttt gaagagtgtg ggggaaagcc tacgcttctc cctgaagttt acagctcagc 600
taatgaagta ctaatatagt atttccacta tttactgtta ttttacctga taagttattg 660
aaccctttgg caattgacca tattgtgagc aaagaatcac tggttattag tctttcaatg 720
aatattgaat tgaagataac tattgtattt ctatcataca ttccttaaag tcttaccgaa 780
aaggctgtgg atttcgtatg gaaataatgt tttattagtg tgctgttgag ggaggtatcc 840
tgttgttctt actcactctt ctcataaaat aggaaatatt ttagttctgt ttcttgggga 900
atatgttact ctttacccta ggatgctatt taagttgtac tgtattagaa cactgggtgt 960
gtcataccgt tatctgtgca gaatatattt ccttattcag aatttctaaa aatttaagtt 1020
ctgtaagggc taatatattc tcttcctatg gttttagacg tttgatgtct tcttagtatg 1080
gcataatgtc atgatttact cattaaactt tgattttgta tgctattttt tcactatagg 1140
atgactataa ttctggtcac taaatataca ctttagatag atgaagaagc ccaaaaacag 1200
ataaattcct gattgctaat ttacatagaa atgtattctc ttggtttttt aaataaaagc 1260
aaaattaaca atgatctgtg ctctgaaagt tttgaaaata tatttgaaca atttgaatat 1320
aaattcatca tttagtcctc aaaatatata tagcattgct aagattttca gatatctatt 1380
gtggatcttt taaaggtttt gaccattttg ttatgaggaa ttatacatgt atcacattca 1440
ctatattaaa attgcacttt tattttttcc tgtgtgtcat gttggttttt ggtacttgta 1500
ttgtcatttg gagaaacaat aaaagatttc taaacca 1537
<210> 202
<211> 3395
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3395)
<223> DUSP6 mRNA
<400> 202
agggcttttg tgcatgctaa ttgcgccatt ggtgcgcaaa agttccgacg cgaagtgtga 60
actctcaaca gaaggaaaca tgagacaact gaagtgccct ggtttatgtg ccctgctcct 120
cctccgctgc cgcctcccct tctttctcct tcctcccgcc gagcccgctg ttgcagcttg 180
tttgcactgg ggcttatccg gagcggaaat tcctttccgt ttttgtgaat gacaaactca 240
ttaacaattc atcaacacaa cctgttccag ccggcccgtc cccacggcaa cagccccttc 300
cgcagcacgc tcattggctg gcccggagaa tgtatccatt gagacgctcg ctgtttgtat 360
ccattgagga gctgcctcgc gcagggggtg tgcgaggctg agtccaagag atagcaaatc 420
gagtcttaaa taatccgggg agaaagacgc ccgggtagat ttgaggtgca gccttggagg 480
gagggattag aagccgctag actttttttc ctcccctctc agtagcacgg agtccgaatt 540
aattggattt cattcactgg ggaggaacaa aaactatctg ggcagcttca ttgagagaga 600
ttcattgaca ctaagagcca gcggctgcag ctgggtgcag agagaacctc cggctttact 660
tctgtctcgt ctgccccaac cgctagcctc ggcttgggta aggcgaggcg gaattaaacc 720
ccgctccgag agcggcagct tcgcgcgcgg tgcgctcggc ctatgcctgc cccgaggggc 780
gtctggtagg caccccgccc tctcccgcag ctcgaccccc atgatagata cgctcagacc 840
cgtgcccttc gcgtcggaaa tggcgatcag caagacggtg gcgtggctca acgagcagct 900
ggagctgggc aacgagcggc tgctgctgat ggactgccgg ccgcaggagc tatacgagtc 960
gtcgcacatc gagtcggcca tcaacgtggc catcccgggc atcatgctgc ggcgcctgca 1020
gaagggtaac ctgccggtgc gcgcgctctt cacgcgcggc gaggaccggg accgcttcac 1080
ccggcgctgt ggcaccgaca cagtggtgct ctacgacgag agcagcagcg actggaacga 1140
gaatacgggc ggcgagtcgg tgctcgggct gctgctcaag aagctcaagg acgagggctg 1200
ccgggcgttc tacctggaag gtggcttcag taagttccaa gccgagttct ccctgcattg 1260
cgagaccaat ctagacggct cgtgtagcag cagctcgccg ccgttgccag tgctggggct 1320
cgggggcctg cggatcagct ctgactcttc ctcggacatc gagtctgacc ttgaccgaga 1380
ccccaatagt gcaacagact cggatggtag tccgctgtcc aacagccagc cttccttccc 1440
agtggagatc ttgcccttcc tctacttggg ctgtgccaaa gactccacca acttggacgt 1500
gttggaggaa ttcggcatca agtacatctt gaacgtcacc cccaatttgc cgaatctctt 1560
tgagaacgca ggagagttta aatacaagca aatccccatc tcggatcact ggagccaaaa 1620
cctgtcccag tttttccctg aggccatttc tttcatagat gaagcccggg gcaagaactg 1680
tggtgtcttg gtacattgct tggctggcat tagccgctca gtcactgtga ctgtggctta 1740
ccttatgcag aagctcaatc tgtcgatgaa cgatgcctat gacattgtca aaatgaaaaa 1800
atccaacata tcccctaact tcaacttcat gggtcagctg ctggacttcg agaggacgct 1860
gggactcagc agcccatgtg acaacagggt tccagcacag cagctgtatt ttaccacccc 1920
ttccaaccag aatgtatacc aggtggactc tctgcaatct acgtgaaaga ccccacaccc 1980
ctccttgctg gaatgtgtct ggcccttcag cagtttctct tggcagcatc agctgggctg 2040
ctttctttgt gtgtggcccc aggtgtcaaa atgacaccag ctgtctgtac tagacaaggt 2100
taccaagtgc ggaattggtt aatactaaca gagagatttg ctccattctc tttggaataa 2160
caggacatgc tgtatagata caggcagtag gtttgctctg tacccatgtg tacagcctac 2220
ccatgcaggg actgggattc gaggacttcc aggcgcatag ggtagaacca aatgataggg 2280
taggagcatg tgttctttag ggccttgtaa ggctgtttcc ttttgcatct ggaactgact 2340
atataattgt cttcaatgaa gactaattca attttgcata tagaggagcc aaagagagat 2400
ttcagctctg tatttgtggt atcagtttgg aaaaaaaaat ctgatactcc atttgattat 2460
tgtaaatatt tgatcttgaa tcacttgaca gtgtttgttt gaattgtgtt tgttttttcc 2520
tttgatgggc ttaaaagaaa ttatccaaag ggagaaagag cagtatgcca cttcttaaaa 2580
cagaacaaaa caaaaaaaga aaattgtgct cttttctaat ccaaagggta tatttgcagc 2640
atgcttgact ttaccaattc tgatgacatc tttacggaca ctattatcac taagaccttg 2700
ttatggcgaa gtctttagtc tttttcatgt attttcctca tgattttttc tctttatgta 2760
gtttgactat gccttacctt tgtaaatatt tttgcttgtg ttgtcgcaaa ggggataatc 2820
tgggaaagac accaaatcat gggctcactt taaaaaaaga aagaataaaa aaaccttcag 2880
ctgtgctaaa cagtatatta cctctgtata aaattcttca gggagtgtca cctcaaatgc 2940
aatactttgg gttggtttct ttcctttaaa aaaatttgta taaaactgga agtgtgtgtg 3000
tgtgagcatg ggtacccatt tgataagaga aatgcatttg attgtgaaga agggagagtt 3060
aaattctcca ttatgttcgt ggtgtaaagt ttagagctgg aatttattat aagaatgtaa 3120
aaccttaaat tattaataaa taactatttt ggctattgaa tgtgtgtttt taaaaactca 3180
gttataccta tgtgtgaagt gacacatttt agaacttttt cattcaggga ttgattttga 3240
cttgtaggca tagtagggca aggttctttt aagcttttcc tagaacgttt ttcagcagca 3300
gtttatgaaa ttcatcgttt gccacgaata aagatgacat cctagaatgg accgactgta 3360
ccgtgtatat gaacaatacc tcttatgagt atagt 3395
<210> 203
<211> 6369
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6369)
<223> EGFR mRNA
<400> 203
gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag 60
cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca 120
gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc 180
acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag 240
ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc 300
tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga 360
gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt 420
tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg 480
atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca 540
cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa 600
attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc 660
tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg 720
ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca 780
acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc 840
ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct 900
gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc 960
agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc 1020
gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt 1080
accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt 1140
gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca 1200
gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca 1260
aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga 1320
atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg 1380
catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc 1440
tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga 1500
cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc 1560
agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg 1620
agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa 1680
taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag 1740
gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct 1800
gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat 1860
gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt 1920
gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg 1980
gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct 2040
gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc 2100
atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag 2160
gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc 2220
tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc 2280
ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca 2340
gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga 2400
tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag 2460
gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag 2520
ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt 2580
gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct 2640
tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc 2700
tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc 2760
accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag 2820
attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca 2880
aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga 2940
gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat 3000
atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc 3060
agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg 3120
cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc 3180
cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact 3240
ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg 3300
agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc 3360
tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc 3420
tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag 3480
gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc 3540
agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc 3600
tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca 3660
accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg 3720
cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg 3780
acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg 3840
cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga 3900
tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc 3960
tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt 4020
tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt 4080
tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag 4140
cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt 4200
ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct 4260
cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa 4320
ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg 4380
cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg 4440
ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc 4500
ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg 4560
tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact 4620
gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt 4680
catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg 4740
gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc 4800
accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag 4860
gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag 4920
ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt 4980
tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc 5040
caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca 5100
agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat 5160
gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc 5220
acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa 5280
ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc 5340
cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc 5400
aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac 5460
agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga 5520
ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa 5580
tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta 5640
tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta 5700
agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga 5760
caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg 5820
tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc 5880
ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag 5940
gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct 6000
ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg 6060
gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag 6120
aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc 6180
agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg 6240
tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa 6300
attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa 6360
aaaaaaaaa 6369
<210> 204
<211> 3137
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3137)
<223> EGR1 mRNA
<400> 204
gagagatccc agcgcgcaga acttggggag ccgccgccgc catccgccgc cgcagccagc 60
ttccgccgcc gcaggaccgg cccctgcccc agcctccgca gccgcggcgc gtccacgccc 120
gcccgcgccc agggcgagtc ggggtcgccg cctgcacgct tctcagtgtt ccccgcgccc 180
cgcatgtaac ccggccaggc ccccgcaact gtgtcccctg cagctccagc cccgggctgc 240
acccccccgc cccgacacca gctctccagc ctgctcgtcc aggatggccg cggccaaggc 300
cgagatgcag ctgatgtccc cgctgcagat ctctgacccg ttcggatcct ttcctcactc 360
gcccaccatg gacaactacc ctaagctgga ggagatgatg ctgctgagca acggggctcc 420
ccagttcctc ggcgccgccg gggccccaga gggcagcggc agcaacagca gcagcagcag 480
cagcgggggc ggtggaggcg gcgggggcgg cagcaacagc agcagcagca gcagcacctt 540
caaccctcag gcggacacgg gcgagcagcc ctacgagcac ctgaccgcag agtcttttcc 600
tgacatctct ctgaacaacg agaaggtgct ggtggagacc agttacccca gccaaaccac 660
tcgactgccc cccatcacct atactggccg cttttccctg gagcctgcac ccaacagtgg 720
caacaccttg tggcccgagc ccctcttcag cttggtcagt ggcctagtga gcatgaccaa 780
cccaccggcc tcctcgtcct cagcaccatc tccagcggcc tcctccgcct ccgcctccca 840
gagcccaccc ctgagctgcg cagtgccatc caacgacagc agtcccattt actcagcggc 900
acccaccttc cccacgccga acactgacat tttccctgag ccacaaagcc aggccttccc 960
gggctcggca gggacagcgc tccagtaccc gcctcctgcc taccctgccg ccaagggtgg 1020
cttccaggtt cccatgatcc ccgactacct gtttccacag cagcaggggg atctgggcct 1080
gggcacccca gaccagaagc ccttccaggg cctggagagc cgcacccagc agccttcgct 1140
aacccctctg tctactatta aggcctttgc cactcagtcg ggctcccagg acctgaaggc 1200
cctcaatacc agctaccagt cccagctcat caaacccagc cgcatgcgca agtaccccaa 1260
ccggcccagc aagacgcccc cccacgaacg cccttacgct tgcccagtgg agtcctgtga 1320
tcgccgcttc tcccgctccg acgagctcac ccgccacatc cgcatccaca caggccagaa 1380
gcccttccag tgccgcatct gcatgcgcaa cttcagccgc agcgaccacc tcaccaccca 1440
catccgcacc cacacaggcg aaaagccctt cgcctgcgac atctgtggaa gaaagtttgc 1500
caggagcgat gaacgcaaga ggcataccaa gatccacttg cggcagaagg acaagaaagc 1560
agacaaaagt gttgtggcct cttcggccac ctcctctctc tcttcctacc cgtccccggt 1620
tgctacctct tacccgtccc cggttactac ctcttatcca tccccggcca ccacctcata 1680
cccatcccct gtgcccacct ccttctcctc tcccggctcc tcgacctacc catcccctgt 1740
gcacagtggc ttcccctccc cgtcggtggc caccacgtac tcctctgttc cccctgcttt 1800
cccggcccag gtcagcagct tcccttcctc agctgtcacc aactccttca gcgcctccac 1860
agggctttcg gacatgacag caaccttttc tcccaggaca attgaaattt gctaaaggga 1920
aaggggaaag aaagggaaaa gggagaaaaa gaaacacaag agacttaaag gacaggagga 1980
ggagatggcc ataggagagg agggttcctc ttaggtcaga tggaggttct cagagccaag 2040
tcctccctct ctactggagt ggaaggtcta ttggccaaca atcctttctg cccacttccc 2100
cttccccaat tactattccc tttgacttca gctgcctgaa acagccatgt ccaagttctt 2160
cacctctatc caaagaactt gatttgcatg gattttggat aaatcatttc agtatcatct 2220
ccatcatatg cctgacccct tgctcccttc aatgctagaa aatcgagttg gcaaaatggg 2280
gtttgggccc ctcagagccc tgccctgcac ccttgtacag tgtctgtgcc atggatttcg 2340
tttttcttgg ggtactcttg atgtgaagat aatttgcata ttctattgta ttatttggag 2400
ttaggtcctc acttggggga aaaaaaaaaa agaaaagcca agcaaaccaa tggtgatcct 2460
ctattttgtg atgatgctgt gacaataagt ttgaaccttt ttttttgaaa cagcagtccc 2520
agtattctca gagcatgtgt cagagtgttg ttccgttaac ctttttgtaa atactgcttg 2580
accgtactct cacatgtggc aaaatatggt ttggtttttc tttttttttt tttttgaaag 2640
tgttttttct tcgtcctttt ggtttaaaaa gtttcacgtc ttggtgcctt ttgtgtgatg 2700
cgccttgctg atggcttgac atgtgcaatt gtgagggaca tgctcacctc tagccttaag 2760
gggggcaggg agtgatgatt tgggggaggc tttgggagca aaataaggaa gagggctgag 2820
ctgagcttcg gttctccaga atgtaagaaa acaaaatcta aaacaaaatc tgaactctca 2880
aaagtctatt tttttaactg aaaatgtaaa tttataaata tattcaggag ttggaatgtt 2940
gtagttacct actgagtagg cggcgatttt tgtatgttat gaacatgcag ttcattattt 3000
tgtggttcta ttttactttg tacttgtgtt tgcttaaaca aagtgactgt ttggcttata 3060
aacacattga atgcgcttta ttgcccatgg gatatgtggt gtatatcctt ccaaaaaatt 3120
aaaacgaaaa taaagta 3137
<210> 205
<211> 5913
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5913)
<223> EMP1 mRNA
<400> 205
acacacccca gtacaccagc agaggaaact tataacctcg ggaggcaggt ccttcccctc 60
agtgcggtca catacttcca gaagagcgga ccagggctgc tgccagcacc tgccactcag 120
agcgcctctg tcgctgggac ccttcagaac tctctttgct cacaagttac caaaaaaaaa 180
agagccaaca tgttggtatt gctggctggt atctttgtgg tccacatcgc tactgttatt 240
atgctatttg ttagcaccat tgccaatgtc tggttggttt ccaatacggt agatgcatca 300
gtaggtcttt ggaaaaactg taccaacatt agctgcagtg acagcctgtc atatgccagt 360
gaagatgccc tcaagacagt gcaggccttc atgattctct ctatcatctt ctgtgtcatt 420
gccctcctgg tcttcgtgtt ccagctcttc accatggaga agggaaaccg gttcttcctc 480
tcaggggcca ccacactggt gtgctggctg tgcattcttg tgggggtgtc catctacact 540
agtcattatg cgaatcgtga tggaacgcag tatcaccacg gctattccta catcctgggc 600
tggatctgct tctgcttcag cttcatcatc ggcgttctct atctggtcct gagaaagaaa 660
taaggccgga cgagttcatg gggatctggg gggtggggag gaggaagccg ttgaatctgg 720
gagggaagtg gaggttgctg tacaggaaaa accgagatag gggagggggg agggggaagc 780
aaagggggga ggtcaaatcc caaaccatta ctgaggggat tctctactgc caagcccctg 840
ccctggggag aaagtagttg gctagtactt tgatgctccc ttgatggggt ccagagagcc 900
tccctgcagc caccagactt ggcctccagc tgttcttagt gacacacact gtctggggcc 960
ccatcagctg ccacaacacc agccccactt ctgggtcatg cactgaggtc cacagaccta 1020
ctgcactgag ttaaaatagc ggtacaagtt ctggcaagag cagatactgt ctttgtgctg 1080
aatacgctaa gcctggaagc catcctgccc ttctgaccca aagcaaaaca tcacattcca 1140
gtctgaagtg cctactgggg ggctttggcc tgtgagccat tgtccctctt tggaacagat 1200
atttagctct gtggaattca gtgacaaaat gggaggagga aagagagttt gtaaggtcat 1260
gctggtgggt tagctaaacc aagaaggaga ccttttcaca atggaaaacc tgggggatgg 1320
tcagagccca gtcgagacct cacacacggc tgtccctcat ggagacctca tgccatggtc 1380
tttgctaggc ctcttgctga aagccaaggc agctcttctg gagtttctct aaagtcacta 1440
gtgaacaatt cggtggtaaa agtaccacac aaactatggg atccaagggg cagtcttgca 1500
acagtgccat gttagggtta tgtttttagg attcccctca atgcagtcag tgtttctttt 1560
aagtatacaa caggagagag atggacatgg ctcattgtag cacaatccta ttactcttcc 1620
tctaacattt ttgaggaagt tttgtctaat tatcaatatt gaggatcagg gctcctaggc 1680
tcagtggtag ctctggctta gacaccacct ggagtgatca cctcttgggg accctgccta 1740
tcccacttca caggtgaggc atggcaattc tggaagctga ttaaaacaca cataaaccaa 1800
aaccaaacaa caggcccttg ggtgaaaggt gctatataat tgtgaagtat taagcctacc 1860
gtatttcagc catgataaga acagagtgcc tgcattccca ggaaaatacg aaaatcccat 1920
gagataaata aaaatatagg tgatgggcag atcttttctt taaaataaaa aagcaaaaac 1980
tcttgtggta cctagtcaga tggtagacga gctgtctgct gccgcaggag cacctctata 2040
caggacttag aagtagtatg ttattcctgg ttaagcaggc attgctttgc cctggagcag 2100
ctattttaag ccatctcaga ttctgtctaa aggggttttt tgggaagacg ttttctttat 2160
cgccctgaga agatctaccc cagggagaat ctgagacatc ttgcctactt ttctttatta 2220
gctttctcct catccatttc ttttatacct ttcctttttg gggagttgtt atgccatgat 2280
ttttggtatt tatgtaaaag gattattact aattctattt ctctatgttt attctagtta 2340
aggaaatgtt gagggcaagc caccaaatta cctaggctga ggttagagag attggccagc 2400
aaaaactgtg ggaagatgaa ctttgtcatt atgatttcat tatcacatga ttatagaagg 2460
ctgtcttagt gcaaaaaaca tacttacatt tcagacatat ccaaagggaa tactcacatt 2520
ttgttaagaa gttgaactat gactggagta aaccatgtat tcccttatct tttacttttt 2580
ttctgtgaca tttatgtctc atgtaatttg cattactctg gtggattgtt ctagtactgt 2640
attgggcttc ttcgttaata gattatttca tatactataa ttgtaaatat tttgatacaa 2700
atgtttataa ctctagggat ataaaaacag attctgattc ccttcattgt gtgaatgttt 2760
ttttctaaaa aaaatgtgga gaaatatgga taattatgac atttatccct cattaagctg 2820
cctatcagtt tgatttggac aacttgacat ttatttgaga cattaagcta ctttctggta 2880
atatattagg catttctgca atagctcttt caggtaactg aatattatta agcatagttt 2940
tatcttgctt tgattaaacc tcttaggcaa aaaatggaac ttcataagct aatacattag 3000
aaaggggtta tgattataaa tcagaaatgc ttgtgacatt aagaaatgag gcacttgtga 3060
aatttctttg aaatagccag ctcctctaat gtgtcttcaa aatataaagt gattcacaaa 3120
ggcatgcatc acacctattt gtagcagccc attcattaca taaaccaggg catacctgtg 3180
tgggctctgt gagtgaaggg aggcttcact actttctgtg agcagtaagg actggtatct 3240
ttctgtgagc aataaggact ggataaagac tgcatatcct tgtgtcgtgt cagcaccaat 3300
acaataagga gggttttaat gtgaagcagg caatcttcca gccccttctg gtcttggatg 3360
aaatagttgc acagagtatt gcaccaaaaa tacacaatgg aggctgaaaa gttcaacata 3420
ttttaagtca attaatcaaa ttgcattgat tcttgatgct ttcttagagg cctacatgat 3480
ttcttagatt gctctgataa actatcataa ggggtccacc tcccctcatt tagctccccc 3540
agggatttct tttcccccat gtcatacacc cagtcctaaa tcaaccccca aggctatcct 3600
tccatccctt ctgcagaggg aacttttgtc agactctgca acaaactcct agctctatcc 3660
agagtgtcct ctgctgctaa gattggtatc tttctcctca aaagcctgga tggtgaatgg 3720
gggtgcatta gtcagaattc tccagagaaa cagaaaaaat aagattcgcg tgtgtgtgca 3780
aacatatata taaataaata aaaatatatt tattttaagg aattgactca catgattttg 3840
aaggcaggca agcccaaagt ctgcaagggg tgggccagca gagagctggt gctacagtgc 3900
gggtctgaaa gttgccagag tcccttttat agagaagctt aaaaaatatt tgttgaatta 3960
aatgtcttag gtagagacaa attgaattaa agtggttaag taaatactct taggtgaaat 4020
ttgtgcaaat tatgagtata aagagggtga gctacagaac tctccatgac cactcaagaa 4080
tgggacccaa aggcaaatga taacttattc attcatcaag ggataaactt gagttatcaa 4140
atggttaata gataaagatc ccactctgcc ttggatttag ccatcgcagt ccctgtgtaa 4200
aaccccaccg gctttcaggc atggaaaaaa atttcacaaa ggccttgaaa gaaggcatat 4260
gaagaccaaa aggatattga gcagggttcc atacttgaat aaaggaagaa actcccttca 4320
atgtttacta agaaatagtt agaatatagc atatcctgta tagatgaaat gtcctagcga 4380
aaatgtttaa atgtatttaa agaagagcta gattttgtgg ggggagagaa gggaatagga 4440
taggctggtg ggaggaagaa tgaaaagaag aaaacttgtt ggaaattttg gagtagattg 4500
tgaggagggg tgactcactt taaagatgta tcatttggag gtagacacga ttttcagagc 4560
acaaaacaga taaggaaaga tgtatgctga ttgtgtggag cccaagggaa ggcggggttt 4620
tggagtctta cgtggctttg tttctgaaag ggagacatgt gaagcctact cctgaggcgg 4680
gaggctgggg acatgaccat caagacctat aattgataaa caactagggg ctgggtgctg 4740
cacctacatg ctggggaaat agaaaatgaa gcagacatgt gtcccatctt cttccagctt 4800
tcagtctagc ttggaaataa atctcatacc tagagaaaat ggaggatctg tgggatgtag 4860
atgaggtggg agcatgaatg cctagggagg gaagaagaaa gattttcagt tcttcagctt 4920
ttcctcatga ccctatctca tgccatgagc aattgtctgg catctcctgt gggttggacc 4980
actgctgcat ttcttacttg ccaacatcac tttgtcccaa atgccattcc tttgttccag 5040
ggcctccttg tcttccatct ggggaactgg aggtgagaag cattataata gcctctctgc 5100
ctttatctac aatctctcca acctgtgctt tatgctgatg tcaggatggg cgttgatgga 5160
tgcttctatc actgtcgggg cagggagggc cagaacacta gcataagatg tcaatatgtc 5220
tatccatatg tcaggtccat actcaactca agcttctggt taactgctga tctattggca 5280
actccagttc ccaataagtt cctcatctcc ttctgagacc acctcagtgt ggacttaatc 5340
gtccacatca ctgtcagcat tttggttaaa accattcaac aagtctccag gaagctccaa 5400
actttccttc atcttcctgt cttcttctga gccctccaaa ctcttccaac ctctacccgt 5460
tacccagttc caaaggtgct tccacacttt caagtatctt tatagcaatg ccccactcct 5520
ggtaccaaat tcctgtatta gtctgttttc acactgctat gaagacatac ttgagactcg 5580
gtaatttata tagaaaagag gtttaattga caaaaaagct aacaaagtga gccctgattc 5640
aaaaatgact gtctacactt ggcacatgag ggactttatg atattaagag attaattaaa 5700
caacagtgga tggggaggaa gaacagactt ttgagctctt cccaatatag gaatgtgtta 5760
gttctaaaaa ttttcttaag ttgtttgctt ggaactcaga gtatattttt ccatacgaaa 5820
aattcagaac tattttattt atgatatggg ctaaaaagac ttctgtaatc tagcttggaa 5880
acttaataat cattaaactt attttcaatg aga 5913
<210> 206
<211> 3176
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3176)
<223> ENO1 mRNA
<400> 206
agtatctgtg ggtacccgga gcacggagat ctcgccggct ttacgttcac ctcggtgtct 60
gcagcaccct ccgcttcctc tcctaggcga cgagacccag tggctagaag ttcaccatgt 120
ctattctcaa gatccatgcc agggagatct ttgactctcg cgggaatccc actgttgagg 180
ttgatctctt cacctcaaaa ggtctcttca gagctgctgt gcccagtggt gcttcaactg 240
gtatctatga ggccctagag ctccgggaca atgataagac tcgctatatg gggaagggta 300
agccttagaa cccacagccc atggcctccc tgcttccagc cccattcctg gccttgccca 360
gtcctgtcct ctctgggtgg cacttgcact tgcaggttta tggcaggtaa acctgctgtg 420
acccatgatg ttgatggaag cagtgcacca ccttgtggac aggaaagttg gtgtgtggat 480
tccggggttc ccgagcctgc atgctctggg tcgagagttc caatgcttgc ttctattgca 540
gtttgttccc aatctgcgaa atactccttc acggttagga caggaaccca agcatgagaa 600
cagggcctgt taactaaaga aaagtttccc catctcccag gagggttctg tgggccctcc 660
agagatcatc agcctcttca cgggctagaa aggatccagg gaaggtctaa ccaatgacct 720
gccctgaatg gtgagctgca ggtgtgtcat ttagtgtgat tttcctgttg actgactcat 780
aggagccctg ctctgtggca gagctagcct ctggctgtat tcaaattgac ttagtgtgtg 840
tgcaacattg acctttctag agatagaaca tgtggccaaa ttacagaaaa gcacataggg 900
ctagatcacg cattctcagt ggggcacccg gaaaactcca aaaaggctgc agggagggga 960
caatgatgaa atcaggttgt gaaacactgg gctggtgtcg cagtggtggt gctgggtgtt 1020
cagtcccgct ttaatgctgt aagaagcact ctacacacac gaacatgtta ccatttgacc 1080
gttgtttaat ggcgtacgtg gggacttagc cggagcagga tgatgctgtg ccttgatggt 1140
aatgagtgct cagtaagtaa gcatttgtgg aagattgaac gcatggcccc tgaaatgctc 1200
tcctctgctt tcctgccccc tcactgtctc tcactcgcag tccttaatca ccggttctct 1260
tctgagtctc tctcattttt ccttcttcat cctctgctgg gcaggcgtct ccagacccat 1320
taagtatatt aatgagttcc tggcaccagc cctgtgcact caggtaactg attgaacagc 1380
ctttagtctg cagttggcgt ttccagtgca tggtcttgca aactaacctc cagtcagatc 1440
gttctgagcc agctgctgtt ttgtgtggct ctaaccctct ggggtcctag gtaggagcac 1500
tcagactggg ccggaaagtc ctccgattct ggggggaaag gggagagggg gaagaggtcc 1560
cacagaaggt cccttggtgg gcttccgcgt cggcctcaac agtggttctc tctaacaatg 1620
ctgctcaagc ctgttttaaa gttaatgtca gtaatttgat ttgattgttc cttccaggtg 1680
tctcaaaggc tgttgagcac atcaataaaa ctattgcgcc tgccctggtt agcaagaaac 1740
tgaacgtcac agaacaagag aagattgaca aactgatgat cgagatggat ggaacagaaa 1800
ataaatctaa gtttggtgcg aacgccattc tgggggtgtc ccttgccgtc tgcaaagctg 1860
gtgccgttga gaagggggtc cccctgtacc gccacatcgc tgacttggct ggcaactctg 1920
aagtcatcct gccagtcccg gcgttcaatg tcatcaatgg cggttctcat gctggcaaca 1980
agctggccat gcaggagttc atgatcctcc cagtcggtgc agcaaacttc agggaagcca 2040
tgcgcattgg agcagaggtt taccacaacc tgaagaatgt catcaaggag aaatatggga 2100
aagatgccac caatgtgggg gatgaaggcg ggtttgctcc caacatcctg gagaataaag 2160
aaggcctgga gctgctgaag actgctattg ggaaagctgg ctacactgat aaggtggtca 2220
tcggcatgga cgtagcggcc tccgagttct tcaggtctgg gaagtatgac ctggacttca 2280
agtctcccga tgaccccagc aggtacatct cgcctgacca gctggctgac ctgtacaagt 2340
ccttcatcaa ggactaccca gtggtgtcta tcgaagatcc ctttgaccag gatgactggg 2400
gagcttggca gaagttcaca gccagtgcag gaatccaggt agtgggggat gatctcacag 2460
tgaccaaccc aaagaggatc gccaaggccg tgaacgagaa gtcctgcaac tgcctcctgc 2520
tcaaagtcaa ccagattggc tccgtgaccg agtctcttca ggcgtgcaag ctggcccagg 2580
ccaatggttg gggcgtcatg gtgtctcatc gttcggggga gactgaagat accttcatcg 2640
ctgacctggt tgtggggctg tgcactgggc agatcaagac tggtgcccct tgccgatctg 2700
agcgcttggc caagtacaac cagctcctca gaattgaaga ggagctgggc agcaaggcta 2760
agtttgccgg caggaacttc agaaacccct tggccaagta agctgtgggc aggcaagccc 2820
ttcggtcacc tgttggctac acagacccct cccctcgtgt cagctcaggc agctcgaggc 2880
ccccgaccaa cacttgcagg ggtccctgct agttagcgcc ccaccgccgt ggagttcgta 2940
ccgcttcctt agaacttcta cagaagccaa gctccctgga gccctgttgg cagctctagc 3000
tttgcagtcg tgtaattggc ccaagtcatt gtttttctcg cctcactttc caccaagtgt 3060
ctagagtcat gtgagcctcg tgtcatctcc ggggtggcca caggctagat ccccggtggt 3120
tttgtgctca aaataaaaag cctcagtgac ccatgagaaa aaaaaaaaaa aaaaaa 3176
<210> 207
<211> 3097
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3097)
<223> ERRFI1 mRNA
<400> 207
gacggcggtc cggtgcgagg cagagtgcta gcgggagcgc gagccagcaa gaggcgcctg 60
cgcgatgtcc gggcccctga gcccgcggcg ctgagccagc cgggacggac atgcgcggga 120
gggcgccgcg gggcagccgc cgctcctccg ggggaatgaa agctactggt tgattttaaa 180
gtgcctgggc ctcacaggtt tggagatgtc ccagaataag gcacaatgtc aatagcagga 240
gttgctgctc aggagatcag agtcccatta aaaactggat ttctacataa tggccgagcc 300
atggggaata tgaggaagac ctactggagc agtcgcagtg agtttaaaaa caacttttta 360
aatattgacc cgataaccat ggcctacagt ctgaactctt ctgctcagga gcgcctaata 420
ccacttgggc atgcttccaa atctgctccg atgaatggcc actgctttgc agaaaatggt 480
ccatctcaaa agtccagctt gccccctctt cttattcccc caagtgaaaa cttgggacca 540
catgaagagg atcaagttgt atgtggtttt aagaaactca cagtgaatgg ggtttgtgct 600
tccacccctc cactgacacc cataaaaaac tccccttccc ttttcccctg tgcccctctt 660
tgtgaacggg gttctaggcc tcttccaccg ttgccaatct ctgaagccct ctctctggat 720
gacacagact gtgaggtgga attcctaact agctcagata cagacttcct tttagaagac 780
tctacacttt ctgatttcaa atatgatgtt cctggcaggc gaagcttccg tgggtgtgga 840
caaatcaact atgcatattt tgatacccca gctgtttctg cagcagatct cagctatgtg 900
tctgaccaaa atggaggtgt cccagatcca aatcctcctc cacctcagac ccaccgaaga 960
ttaagaaggt ctcattcggg accagctggc tcctttaaca agccagccat aaggatatcc 1020
aactgttgta tacacagagc ttctcctaac tccgatgaag acaaacctga ggttcccccc 1080
agagttccca tacctcctag accagtaaag ccagattata gaagatggtc agcagaagtt 1140
acttcgagca cctatagtga tgaagacagg cctcccaaag taccgccaag agaacctttg 1200
tcaccgagta actcgcgcac accgagtccc aaaagccttc cgtcttacct caatggggtc 1260
atgcccccga cacagagctt tgcccctgat cccaagtatg tcagcagcaa agcactgcaa 1320
agacagaaca gcgaaggatc tgccagtaag gttccttgca ttctgcccat tattgaaaat 1380
gggaagaagg ttagttcaac acattattac ctactacctg aacgaccacc atacctggac 1440
aaatatgaaa aattttttag ggaagcagaa gaaacaaatg gaggcgccca aatccagcca 1500
ttacctgctg actgcggtat atcttcagcc acagaaaagc cagactcaaa aacaaaaatg 1560
gatctgggtg gccacgtgaa gcgtaaacat ttatcctatg tggtttctcc ttagaccttg 1620
gggtcatggt tcagcagagg ttacatagga gcaaatggtt ctcaattttc cagtttgatt 1680
gaagtgcaga gaaaaatccc ttagattgca aaataaaata gttgaactct ctgtcttcat 1740
gtggaaggtt tagagcagtt gtgagatgct gttatgctga gaaaccctga ctttgttagt 1800
gttggaaaaa agtcttacaa gtctataatt taaagatgtg atggtgggga ggggaggatg 1860
gggaagcttt ttatatatgc atacattaca tacctatata taaacttgtg gtataaccat 1920
agaccatagc tgcaggttaa ccaattagtt actatcgtag agtaatatat attcagaata 1980
ataaactcaa gctggagaaa tgagtcctga tagactgaaa attgagcaaa tggaagaaga 2040
tacagtattg tttagatcag aatcattaaa aaatattttt gtttagtaag tttgaagatt 2100
tctggctttt aggccttttc tattttgttc catttatttt tgcaggcaat cttttccatg 2160
gagggcaggg tatccattct ttaccatggg tgtacctgct taggttaaaa atcataccaa 2220
ggcctcatac ttccaggttt catgttgcgt cttgttgagg gagggagagc aggttacttg 2280
gcaaccatat tgtcacctgt acctgtcaca catcttgaaa aataaaacga taatagaact 2340
agtgactaat tttcccttac agttcctgct tggtcccacc cactgaagta gctcatcgta 2400
gtgcgggccg tattagaggc agtggggtac gttagactca gatggaaaag tattctaggt 2460
gccagtgtta ggatgtcagt tttacaaaat aatgaagcaa ttagctatgt gattgagagt 2520
tattgtttgg ggatgtgtgt tgtggttttg cttttttttt ttagactgta ttaataaaca 2580
tacaacacaa gctggccttg tgttgctggt tcctattcag tatttcctgg ggattgtttg 2640
ctttttaagt aaaacacttc tgacccatag ctcagtatgt ctgaattcca gaggtcacat 2700
cagcatcttt ctgctttgaa aactctcaca gctgtggctg cttcacttag atgcagtgag 2760
acacatagtt ggtgttccga ttttcacatc cttccatgta tttatcttga agagataagc 2820
acagaagaga aggtgctcac taacagaggt acattactgc aatgttctct taacagttaa 2880
acaagctgtt tacagtttaa actgctgaat attatttgag ctatttaaag cttattatat 2940
tttagtatga actaaatgaa ggttaaaaca tgcttaagaa aaatgcactg atttctgcat 3000
tatgtgtaca gtattggaca aaggatttta ttcattttgt tgcattattt tgaatattgt 3060
cttttcattt taataaagtt ataatactta tttatga 3097
<210> 208
<211> 2089
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2089)
<223> ESM1 mRNA
<400> 208
agtttggacg gctgcttccc accagcaaag accacgactg gagagccgag ccggaggcag 60
ctgggaaaca tgaagagcgt cttgctgctg accacgctcc tcgtgcctgc acacctggtg 120
gccgcctgga gcaataatta tgcggtggac tgccctcaac actgtgacag cagtgagtgc 180
aaaagcagcc cgcgctgcaa gaggacagtg ctcgacgact gtggctgctg ccgagtgtgc 240
gctgcagggc ggggagaaac ttgctaccgc acagtctcag gcatggatgg catgaagtgt 300
ggcccggggc tgaggtgtca gccttctaat ggggaggatc cttttggtga agagtttggt 360
atctgcaaag actgtcccta cggcaccttc gggatggatt gcagagagac ctgcaactgc 420
cagtcaggca tctgtgacag ggggacggga aaatgcctga aattcccctt cttccaatat 480
tcagtaacca agtcttccaa cagatttgtt tctctcacgg agcatgacat ggcatctgga 540
gatggcaata ttgtgagaga agaagttgtg aaagagaatg ctgccgggtc tcccgtaatg 600
aggaaatggt taaatccacg ctgatcccgg ctgtgatttc tgagagaagg ctctattttc 660
gtgattgttc aacacacagc caacatttta ggaactttct agattatagc ataaggacat 720
gtaatttttg aagaccaaat gtgatgcatg gtggatccag aaaacaaaaa gtaggatact 780
tacaatccat aacatccata tgactgaaca cttgtatgtg tttgttaaat attcgaatgc 840
atgtagattt gttaaatgtg tgtgtatagt aacactgaag aactaaaaat gcaatttagg 900
taatcttacg tggagacagg tcaaccaaag agggagctag gcaaagctga agaccgcagt 960
gagtcaaatt agttctttga ctttgatgta cattaatgtt gggatatgga atgaagactt 1020
aagagcagga gaagatgggg agggggtggg agtgggaaat aaaatattta gcccttcctt 1080
ggtaggtagc ttctctagaa tttaattgtg cttttttttt tttttttggc tttgggaaaa 1140
gtcaaaataa aacaaccaga aaacccctga aggaagtaag atgtttgaag cttatggaaa 1200
tttgagtaac aaacagcttt gaactgagag caatttcaaa aggctgctga tgtagttccc 1260
gggttacctg tatctgaagg acggttctgg ggcataggaa acacatacac ttccataaat 1320
agctttaacg tatgccacct cagagataaa tctaagaagt attttaccca ctggtggttt 1380
gtgtgtgtat gaaggtaaat atttatatat ttttataaat aaatgtgtta gtgcaagtca 1440
tcttccctac ccatatttat catcctcttg aggaaagaaa tctagtatta tttgttgaaa 1500
atggttagaa taaaactatg actctataag gttttcaaac atctgaggca tgataaattt 1560
attatccata attatagtaa taataacctt aataagcata agaaaaacag agtcactctg 1620
gatttcaaaa atgtcaaaaa atgagcaaca gagggtcctt atttaaacat aagtgctgtg 1680
acttaggtga attttcaatt taaggtagaa aataagtttt taggaggttt gtaaaagaag 1740
aatcaatttt cagcagaaaa catgtcaact ttaaaatata gtttattttc atattttttt 1800
cttttaaact tggttgataa gtggaattag gagtatattt gaaagaatct tagcacaaac 1860
aggactgttg tactagatgt tcttaggaaa tatctcagaa gtattttatt tgaagtgaag 1920
aacttattta agaattattt cagtatttac ctgtatttta ttcttgaagt tggccaacag 1980
agttgtgaat gtgtgtggga aggcctttga atgtaaagct gcataagctg ttaggttttg 2040
ttttaaaagg acatgtttat tattgttcaa taaaaaagaa caagataca 2089
<210> 209
<211> 2248
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2248)
<223> FGA mRNA
<400> 209
aggatgggaa ctaggagtgg cagcaatcct ttctttcagc tggagtgctc ctcaggagcc 60
agccccaccc ttagaaaaga tgttttccat gaggatcgtc tgcctggtcc taagtgtggt 120
gggcacagca tggactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt 180
gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt 240
ctgctctgat gaagactgga actacaaatg cccttctggc tgcaggatga aagggttgat 300
tgatgaagtc aatcaagatt ttacaaacag aataaataag ctcaaaaatt cactatttga 360
atatcagaag aacaataagg attctcattc gttgaccact aatataatgg aaattttgag 420
aggcgatttt tcctcagcca ataaccgtga taatacctac aaccgagtgt cagaggatct 480
gagaagcaga attgaagtcc tgaagcgcaa agtcatagaa aaagtacagc atatccagct 540
tctgcagaaa aatgttagag ctcagttggt tgatatgaaa cgactggagg tggacattga 600
tattaagatc cgatcttgtc gagggtcatg cagtagggct ttagctcgtg aagtagatct 660
gaaggactat gaagatcagc agaagcaact tgaacaggtc attgccaaag acttacttcc 720
ctctagagat aggcaacact taccactgat aaaaatgaaa ccagttccag acttggttcc 780
cggaaatttt aagagccagc ttcagaaggt acccccagag tggaaggcat taacagacat 840
gccgcagatg agaatggagt tagagagacc tggtggaaat gagattactc gaggaggctc 900
cacctcttat ggaaccggat cagagacgga aagccccagg aaccctagca gtgctggaag 960
ctggaactct gggagctctg gacctggaag tactggaaac cgaaaccctg ggagctctgg 1020
gactggaggg actgcaacct ggaaacctgg gagctctgga cctggaagta ctggaagctg 1080
gaactctggg agctctggaa ctggaagtac tggaaaccaa aaccctggga gccctagacc 1140
tggtagtacc ggaacctgga atcctggcag ctctgaacgc ggaagtgctg ggcactggac 1200
ctctgagagc tctgtatctg gtagtactgg acaatggcac tctgaatctg gaagttttag 1260
gccagatagc ccaggctctg ggaacgcgag gcctaacaac ccagactggg gcacatttga 1320
agaggtgtca ggaaatgtaa gtccagggac aaggagagag taccacacag aaaaactggt 1380
cacttctaaa ggagataaag agctcaggac tggtaaagag aaggtcacct ctggtagcac 1440
aaccaccacg cgtcgttcat gctctaaaac cgttactaag actgttattg gtcctgatgg 1500
tcacaaagaa gttaccaaag aagtggtgac ctccgaagat ggttctgact gtcccgaggc 1560
aatggattta ggcacattgt ctggcatagg tactctggat gggttccgcc ataggcaccc 1620
tgatgaagct gccttcttcg acactgcctc aactggaaaa acattcccag gtttcttctc 1680
acctatgtta ggagagtttg tcagtgagac tgagtctagg ggctcagaat ctggcatctt 1740
cacaaataca aaggaatcca gttctcatca ccctgggata gctgaattcc cttcccgtgg 1800
taaatcttca agttacagca aacaatttac tagtagcacg agttacaaca gaggagactc 1860
cacatttgaa agcaagagct ataaaatggc agatgaggcc ggaagtgaag ccgatcatga 1920
aggaacacat agcaccaaga gaggccatgc taaatctcgc cctgtcagag gtatccacac 1980
ttctcctttg gggaagcctt ccctgtcccc ctagactaag ttaaatattt ctgcacagtg 2040
ttcccatggc cccttgcatt tccttcttaa ctctctgtta cacgtcattg aaactacact 2100
tttttggtct gtttttgtgc tagactgtaa gttccttggg ggcagggcct ttgtctgtct 2160
catctctgta ttcccaaatg cctaacagta cagagccatg actcaataaa tacatgttaa 2220
atggatgaat gaattcctct gaaactct 2248
<210> 210
<211> 6781
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6781)
<223> FGF2 mRNA
<400> 210
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60
gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg 120
ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt 180
gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc 240
gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga 300
ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc 360
ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc 420
gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga 480
gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc 540
acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc 600
ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc 660
aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta 720
tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg 780
aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg 840
tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag 900
ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat 960
ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat 1020
gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta 1080
accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata 1140
ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc 1200
tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa 1260
tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct 1320
tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt 1380
tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt 1440
aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat 1500
acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt 1560
cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg 1620
aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg 1680
tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa 1740
aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat 1800
tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct 1860
caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca 1920
agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata 1980
tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt 2040
aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt 2100
tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc 2160
ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa 2220
ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa 2280
tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat 2340
ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca 2400
aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt 2460
cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt 2520
ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa 2580
gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta 2640
ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg 2700
gaaagatgca tagaaagagt ataatgtttt aaaacataag gcatttgtct gccatttttc 2760
aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa 2820
caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct 2880
gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg 2940
tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt 3000
ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa 3060
ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt 3120
gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat 3180
acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata 3240
tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg 3300
aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat 3360
ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta 3420
tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc 3480
tatgctgttt ctatgtcgtg gaagcactgg atgggggtag tgagcaaatc tgccctgctc 3540
agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta 3600
acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt 3660
atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat 3720
tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata 3780
ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac 3840
taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt 3900
ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat 3960
atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg 4020
ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc 4080
tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt 4140
aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt 4200
tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa 4260
acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac 4320
aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt 4380
tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat 4440
ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag 4500
ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta 4560
gctgctttca gggttttatg aattttcagg caaagcttta atttacacta agcttaggaa 4620
gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat 4680
gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa 4740
aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc 4800
ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag 4860
tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa 4920
aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata 4980
gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc 5040
accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc 5100
acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg 5160
tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg 5220
atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt 5280
ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag 5340
aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa 5400
ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg 5460
aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc 5520
tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg 5580
agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt 5640
actatgtttt gactacctga ctattaaaaa taaatagtag atacaatttt cataaagtga 5700
agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta 5760
aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat 5820
tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat 5880
atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag 5940
gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta 6000
tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa 6060
attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc 6120
ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct 6180
ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata 6240
aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat 6300
tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc 6360
atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc 6420
caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat 6480
gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct 6540
agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat 6600
aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca 6660
gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt 6720
gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tcccaaaaaa 6780
a 6781
<210> 211
<211> 3936
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3936)
<223> FGF7 mRNA
<400> 211
agttttaatt gcttccaatg aggtcagcaa aggtatttat cgaaaagccc tgaataaaag 60
gctcacacac acacacaagc acacacgcgc tcacacacag agagaaaatc cttctgcctg 120
ttgatttatg gaaacaatta tgattctgct ggagaacttt tcagctgaga aatagtttgt 180
agctacagta gaaaggctca agttgcacca ggcagacaac agacatggaa ttcttatata 240
tccagctgtt agcaacaaaa caaaagtcaa atagcaaaca gcgtcacagc aactgaactt 300
actacgaact gtttttatga ggatttatca acagagttat ttaaggagga atcctgtgtt 360
gttatcagga actaaaagga taaggctaac aatttggaaa gagcaactac tctttcttaa 420
atcaatctac aattcacaga taggaagagg tcaatgacct aggagtaaca atcaactcaa 480
gattcatttt cattatgtta ttcatgaaca cccggagcac tacactataa tgcacaaatg 540
gatactgaca tggatcctgc caactttgct ctacagatca tgctttcaca ttatctgtct 600
agtgggtact atatctttag cttgcaatga catgactcca gagcaaatgg ctacaaatgt 660
gaactgttcc agccctgagc gacacacaag aagttatgat tacatggaag gaggggatat 720
aagagtgaga agactcttct gtcgaacaca gtggtacctg aggatcgata aaagaggcaa 780
agtaaaaggg acccaagaga tgaagaataa ttacaatatc atggaaatca ggacagtggc 840
agttggaatt gtggcaatca aaggggtgga aagtgaattc tatcttgcaa tgaacaagga 900
aggaaaactc tatgcaaaga aagaatgcaa tgaagattgt aacttcaaag aactaattct 960
ggaaaaccat tacaacacat atgcatcagc taaatggaca cacaacggag gggaaatgtt 1020
tgttgcctta aatcaaaagg ggattcctgt aagaggaaaa aaaacgaaga aagaacaaaa 1080
aacagcccac tttcttccta tggcaataac ttaattgcat atggtatata aagaaccagt 1140
tccagcaggg agatttcttt aagtggactg ttttctttct tctcaaaatt ttctttcctt 1200
ttatttttta gtaatcaaga aaggctggaa aactactgaa aaactgatca agctggactt 1260
gtgcatttat gtttgtttta agacactgca ttaaagaaag atttgaaaag tatacacaaa 1320
aatcagattt agtaactaaa ggttgtaaaa aattgtaaaa ctggttgtac aatcatgatg 1380
ttagtaacag taattttttt cttaaattaa tttaccctta agagtatgtt agatttgatt 1440
atctgataat gattatttaa atattcctat ctgcttataa aatggctgct ataataataa 1500
taatacagat gttgttatat aaggtatatc agacctacag gcttctggca ggatttgtca 1560
gataatcaag ccacactaac tatggaaaat gagcagcatt ttaaatgctt tctagtgaaa 1620
aattataatc tacttaaact ctaatcagaa aaaaaattct caaaaaaact attatgaaag 1680
tcaataaaat agataattta acaaaagtac aggattagaa catgcttata cctataaata 1740
agaacaaaat ttctaatgct gctcaagtgg aaagggtatt gctaaaagga tgtttccaaa 1800
aatcttgtat ataagatagc aacagtgatt gatgataata ctgtacttca tcttacttgc 1860
cacaaaataa cattttataa atcctcaaag taaaattgag aaatctttaa gtttttttca 1920
agtaacataa tctatctttg tataattcat atttgggaat atggctttta ataatgttct 1980
tcccacaaat aatcatgctt ttttcctatg gttacagcat taaactctat tttaagttgt 2040
ttttgaactt tattgttttg ttatttaagt ttatgttatt tataaaaaaa aaaccttaat 2100
aagctgtatc tgtttcatat gcttttaatt ttaaaggaat aacaaaactg tctggctcaa 2160
cggcaagttt ccctcccttt tctgactgac actaagtcta gcacacagca cttgggccag 2220
caaatcctgg aaggcagaca aaaataagag cctgaagcaa tgcttacaat agatgtctca 2280
cacagaacaa tacaaatatg taaaaaatct ttcaccacat attcttgcca attaattgga 2340
tcatataagt aaaatcatta caaatataag tatttacagg attttaaagt tagaatatat 2400
ttgaatgcat gggtagaaaa tatcatattt taaaactatg tatatttaaa tttagtaatt 2460
ttctaatctc tagaaatctc tgctgttcaa aaggtggcag cactgaaagt tgttttcctg 2520
ttagatggca agagcacaat gcccaaaata gaagatgcag ttaagaataa ggggccctga 2580
atgtcatgaa ggcttgaggt cagcctacag ataacaggat tattacaagg atgaatttcc 2640
acttcaaaag tctttcattg gcagatcttg gtagcacttt atatgttcac caatgggagg 2700
tcaatattta tctaatttaa aaggtatgct aaccactgtg gttttaattt caaaatattt 2760
gtcattcaag tccctttaca taaatagtat ttggtaatac atttatagat gagagttata 2820
tgaaaaggct aggtcaacaa aaacaataga ttcatttaat tttcctgtgg ttgacctata 2880
cgaccaggat gtagaaaact agaaagaact gcccttcctc agatatactc ttgggagaga 2940
gcatgaatgg tattctgaac tatcacctga ttcaaggact ttgctagcta ggttttgagg 3000
tcaggcttca gtaactgtag tcttgtgagc atattgaggg cagaggagga cttagttttt 3060
catatgtgtt tccttagtgc ctagcagact atctgttcat aatcagtttt cagtgtgaat 3120
tcactgaatg tttatagaca aaagaaaata cacactaaaa ctaatcttca ttttaaaagg 3180
gtaaaacatg actatacaga aatttaaata gaaatagtgt atatacatat aaaatacaag 3240
ctatgttagg accaaatgct ctttgtctat ggagttatac ttccatcaaa ttacatagca 3300
atgctgaatt aggcaaaacc aacatttagt ggtaaatcca ttcctggtag tataagtcac 3360
ctaaaaaaga cttctagaaa tatgtacttt aattatttgt ttttctccta tttttaaatt 3420
tattatgcaa attttagaaa ataaaatttg ctctagttac acacctttag aattctagaa 3480
tattaaaact gtaaggggcc tccatccctc ttactcattt gtagtctagg aaattgagat 3540
tttgatacac ctaaggtcac gcagctgggt agatatacag ctgtcacaag agtctagatc 3600
agttagcaca tgctttctac tcttcgatta ttagtattat tagctaatgg tctttggcat 3660
gtttttgttt tttatttctg ttgagatata gcctttacat ttgtacacaa atgtgactat 3720
gtcttggcaa tgcacttcat acacaatgac taatctatac tgtgatgatt tgactcaaaa 3780
ggagaaaaga aattatgtag ttttcaattc tgattcctat tcaccttttg tttatgaatg 3840
gaaagctttg tgcaaaatat acatataagc agagtaagcc ttttaaaaat gttctttgaa 3900
agataaaatt aaatacatga gtttctaaca attaga 3936
<210> 212
<211> 627
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(627)
<223> FGF10 mRNA
<400> 212
atgtggaaat ggatactgac acattgtgcc tcagcctttc cccacctgcc cggctgctgc 60
tgctgctgct ttttgttgct gttcttggtg tcttccgtcc ctgtcacctg ccaagccctt 120
ggtcaggaca tggtgtcacc agaggccacc aactcttctt cctcctcctt ctcctctcct 180
tccagcgcgg gaaggcatgt gcggagctac aatcaccttc aaggagatgt ccgctggaga 240
aagctattct ctttcaccaa gtactttctc aagattgaga agaacgggaa ggtcagcggg 300
accaagaagg agaactgccc gtacagcatc ctggagataa catcagtaga aatcggagtt 360
gttgccgtca aagccattaa cagcaactat tacttagcca tgaacaagaa ggggaaactc 420
tatggctcaa aagaatttaa caatgactgt aagctgaagg agaggataga ggaaaatgga 480
tacaatacct atgcatcatt taactggcag cataatggga ggcaaatgta tgtggcattg 540
aatggaaaag gagctccaag gagaggacag aaaacacgaa ggaaaaacac ctctgctcac 600
tttcttccaa tggtggtaca ctcatag 627
<210> 213
<211> 1759
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1759)
<223> FOSL1 mRNA
<400> 213
acgggccaag gcggcgcgtc tcgggggtgg agcctggagg tgaccgcgcc gctgcaacgc 60
ccccaccccc cgcggtcgca gtggttcagc ccgagaactt ttcattcata aaaagaaaag 120
actccgcacg gcgcgggtga gtcagaaccc agcagccgtg taccccgcag agccgccagc 180
cccgggcatg ttccgagact tcggggaacc cggcccgagc tccgggaacg gcggcgggta 240
cggcggcccc gcgcagcccc cggccgcagc gcaggcagcc cagcagaagt tccacctggt 300
gccaagcatc aacaccatga gtggcagtca ggagctgcag tggatggtac agcctcattt 360
cctggggccc agcagttacc ccaggcctct gacctaccct cagtacagcc ccccacaacc 420
ccggccagga gtcatccggg ccctggggcc gcctccaggg gtacgtcgaa ggccttgtga 480
acagatcagc ccggaggaag aggagcgccg ccgagtaagg cgcgagcgga acaagctggc 540
tgcggccaag tgcaggaacc ggaggaagga actgaccgac ttcctgcagg cggagactga 600
caaactggaa gatgagaaat ctgggctgca gcgagagatt gaggagctgc agaagcagaa 660
ggagcgccta gagctggtgc tggaagccca ccgacccatc tgcaaaatcc cggaaggagc 720
caaggagggg gacacaggca gtaccagtgg caccagcagc ccaccagccc cctgccgccc 780
tgtaccttgt atctcccttt ccccagggcc tgtgcttgaa cctgaggcac tgcacacccc 840
cacactcatg accacaccct ccctaactcc tttcaccccc agcctggtct tcacctaccc 900
cagcactcct gagccttgtg cctcagctca tcgcaagagt agcagcagca gcggagaccc 960
atcctctgac ccccttggct ctccaaccct cctcgctttg tgaggcgcct gagccctact 1020
ccctgcagat gccaccctag ccaatgtctc ctccccttcc cccaccggtc cagctggcct 1080
ggacagtatc ccacatccaa ctccagcaac ttcttctcca tccctctaat gagactgacc 1140
atattgtgct tcacagtaga gccagcttgg ggccaccaaa gctgcccact gtttctcttg 1200
agctggcctc tctagcacaa tttgcactaa atcagagaca aaatatttcc catttgtgcc 1260
agaggaatcc tggcagccca gagactttgt agatccttag aggtcctctg gagccctaac 1320
cccttccaga tcactgccac actctccatc accctcttcc tgtgatccac ccaaccctat 1380
ctcctgacag aaggtgccac tttacccacc tagaacacta actcaccagc cccactgcca 1440
gcagcagcag gtgattggac caggccattc tgccgccccc tcctgaaccg cacagctcag 1500
gaggcgccct tggcttctgt gatgagctga tctgcggatc tcagctttga gaagccttca 1560
gctccaggga atccaagcct ccacagcgag ggcagctgct atttattttc ctaaagagag 1620
tatttttata caaacctacc aaaatggaat aaaaggcttg aagctgtggc ctgagtgcct 1680
cactggaccc agaggccaat gggagagtat ttggagccct aggtcccagc cttagctcta 1740
cagactcact gcaaaaaaa 1759
<210> 214
<211> 2098
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2098)
<223> FST mRNA
<400> 214
ttgggaaggg tttccagaag gtgggaaatg tcacctgatt cacactgaac ttttgaaagc 60
tccccacccc caaggagccg cgcacaccct cgctcgcggc cgccctccca cagccccaca 120
cactgggaga ccgcccaccg caaaccgcgg agacccccgt ctagatttaa agcgcggctg 180
cgcccggctt ctgacgtcca ttgaatcgcg cgggcggccg gcggcgagcg cggggctgcg 240
ccgggatcgc tgcgccctcc gccgctggcc tctgcgacgc gcgccgctcg cccgagccac 300
ccgccgccgc gccggctccc cgcgccgctg cgctcctcgc cccgcgcctg cccccaggat 360
ggtccgcgcg aggcaccagc cgggtgggct ttgcctcctg ctgctgctgc tctgccagtt 420
catggaggac cgcagtgccc aggctgggaa ctgctggctc cgtcaagcga agaacggccg 480
ctgccaggtc ctgtacaaga ccgaactgag caaggaggag tgctgcagca ccggccggct 540
gagcacctcg tggaccgagg aggacgtgaa tgacaacaca ctcttcaagt ggatgatttt 600
caacgggggc gcccccaact gcatcccctg taaagaaacg tgtgagaacg tggactgtgg 660
acctgggaaa aaatgccgaa tgaacaagaa gaacaaaccc cgctgcgtct gcgccccgga 720
ttgttccaac atcacctgga agggtccagt ctgcgggctg gatgggaaaa cctaccgcaa 780
tgaatgtgca ctcctaaagg caagatgtaa agagcagcca gaactggaag tccagtacca 840
aggcagatgt aaaaagactt gtcgggatgt tttctgtcca ggcagctcca catgtgtggt 900
ggaccagacc aataatgcct actgtgtgac ctgtaatcgg atttgcccag agcctgcttc 960
ctctgagcaa tatctctgtg ggaatgatgg agtcacctac tccagtgcct gccacctgag 1020
aaaggctacc tgcctgctgg gcagatctat tggattagcc tatgagggaa agtgtatcaa 1080
agcaaagtcc tgtgaagata tccagtgcac tggtgggaaa aaatgtttat gggatttcaa 1140
ggttgggaga ggccggtgtt ccctctgtga tgagctgtgc cctgacagta agtcggatga 1200
gcctgtctgt gccagtgaca atgccactta tgccagcgag tgtgccatga aggaagctgc 1260
ctgctcctca ggtgtgctac tggaagtaaa gcactccgga tcttgcaact gaatctgccc 1320
gtaaaacctg agccattgat tcttcagaac tttctgcagt ttttgacttc atagattatg 1380
ctttaaaaaa atttttttaa cttattgcat aacagcagat gccaaaaaca aaaaaagcat 1440
ctcactgcaa gtcacataaa aatgcaacgc tgtaatatgg ctgtatcaga gggctttgaa 1500
aacatacact gagctgcttc tgcgctgttg ttgtccgtat ttaaacaaca gctcccctgt 1560
attcccccat ctagccattt cggaagacac cgaggaagag gaggaagatg aagaccagga 1620
ctacagcttt cctatatctt ctattctaga gtggtaaact ctctataagt gttcagtgtt 1680
gacatagcct ttgtgcaaaa aaaaaaaaaa aaaaaaagaa aaagaaaaaa agaaaaatat 1740
attgtccata ctgtaaataa gtgtatgctt atttatttgg ggggaaaact atacattaaa 1800
ggacctttgt cctaaagctc tctcccaggc caccttgtta ctcattggac acggagaggc 1860
attcattgtg aggtctactg gatgaggccc atagttgaga cttgtagaca tttatttata 1920
ctgtgtcatg ttttataatt tatacataaa atgtctggtt gactgtatac cttgtttttg 1980
aagaaattta ttcgtgaaag gaagagcagt tgttatttat tgtgaggtct cttgcttgta 2040
aagtaaaagc tttttttcct tgtaaaccat ttaagtccat tccttactat tcactcac 2098
<210> 215
<211> 3275
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3275)
<223> HAS2 mRNA
<400> 215
gaagtcaaga cgtctggaaa gaattaccca gtcctggctt cgagcagccc attgaaccag 60
agacttgaaa cagccccagc caaagacttt tctcccaatt ctgcgcttcc tgggttctgc 120
tgagtcttcc acaggctttt tttttttttt tttttttttt taagacgaaa aagagatttt 180
ctgttatcgg gggcagaaag actgaagccc aaaaaaaaaa aaaaaaaaaa aagaaaagaa 240
aagaaaaaag aaaagttaat ttatttttaa agcataattt ttttaagaat tagactgaag 300
tgcaacggaa acataaagag aatattagtg aaattatttt ttaaagtggg gaagaatcaa 360
acatttaaga ctcccctatc ctttttaaat gttgttttta aatttcttat tttttttggc 420
cggtcgtctc aaattcatct gatctcttat tacctcaatt ttggaaactg cccgccaccg 480
accctccggg accacacaga caggctgagg acgactttat gaccaagagc tgaacaagat 540
gcattgtgag aggtttctat gtatcctgag aataattgga accacactct ttggagtctc 600
tctcctcctt ggaatcacag ctgcttatat tgttggctac cagtttatcc aaacggataa 660
ttactatttc tcttttggac tgtatggtgc ctttttggca tcacacctca tcatccaaag 720
cctgtttgcc tttttggagc accgaaaaat gaaaaaatcc ctagaaaccc ccataaagtt 780
gaacaaaaca gttgcccttt gcatcgctgc ctatcaagaa gatccagact acttaaggaa 840
atgtttgcaa tctgtgaaaa ggctaaccta ccctgggatt aaagttgtca tggtcataga 900
tgggaactca gaagatgacc tttacatgat ggacatcttc agtgaagtca tgggcagaga 960
caaatcagcc acttatatct ggaagaacaa cttccacgaa aagggtcccg gtgagacaga 1020
tgagtcacat aaagaaagct cgcaacacgt aacgcaattg gtcttgtcca acaaaagtat 1080
ctgcatcatg caaaaatggg gtggaaaaag agaagtcatg tacacagcct tcagagcact 1140
gggacgaagt gtggattatg tacaggtttg tgattcagac actatgcttg acccagcctc 1200
atctgtggag atggtaaaag ttttagaaga agatcccatg gttggaggtg ttgggggaga 1260
tgtccagatt ttaaacaagt acgattcctg gatctcattc ctcagcagtg taagatattg 1320
gatggctttt aatatagaaa gggcctgtca gtcttatttt gggtgtgttc agtgcattag 1380
tggacctctg ggaatgtaca gaaactcctt gttgcatgag tttgtggaag attggtacaa 1440
tcaagaattt atgggcaacc aatgtagctt tggtgatgac aggcatctca cgaaccgggt 1500
gctgagcctg ggctatgcaa caaaatacac agctcgatct aagtgcctta ctgaaacacc 1560
tatagaatat ctcagatggc taaaccagca gacccgttgg agcaagtcct acttccgaga 1620
atggctgtac aatgcaatgt ggtttcacaa acatcacttg tggatgacct acgaagcgat 1680
tatcactgga ttctttcctt tctttctcat tgccacagta atccagctct tctaccgggg 1740
taaaatttgg aacattctcc tcttcttgtt aactgtccag ctagtaggtc tcataaaatc 1800
atcttttgcc agctgcctta gaggaaatat cgtcatggtc ttcatgtctc tctactcagt 1860
gttatacatg tcgagtttac ttcccgccaa gatgtttgca attgcaacaa taaacaaagc 1920
tgggtggggc acatcaggaa ggaaaaccat tgttgttaat ttcataggac tcattccagt 1980
atcagtttgg tttacaatcc tcctgggtgg tgtgattttc accatttata aggagtctaa 2040
aaggccattt tcagaatcca aacagacagt tctaattgtt ggaacgttgc tctatgcatg 2100
ctattgggtc atgcttttga cgctgtatgt agttctcatc aataagtgtg gcaggcggaa 2160
gaagggacaa caatatgaca tggtgcttga tgtatgatct tccatgtttt gacgtttgca 2220
gtcacacaca acaccttagt tcctctaggg gctgtacagt attgtggcat cagataatgc 2280
caccaaagga gacatatcac tgctgctggg acttgaacaa agacatttat atgggtttat 2340
tttcattctg ccaaagtaaa acaatacatc aacaagaaga aactcagatt taacctgtta 2400
tttctatgaa aatgggatga attctttgtt tatgcacttt ttccttactg tgcatccgcc 2460
tgaaagtgtt ttgccctata tacctcacta gccatgcttt atgtgggtta tcatggaaga 2520
aaaggatttt ggaaactcaa ggaaaagttc tttcaaccta tacaacctaa cttatggact 2580
gttttgatag atgataattt ttttttttta ggaaggattt tctttttaac tttaccaaat 2640
gaaatgccaa aggaagtttt aaaggccgtt ggctgtgctg tattttgata taattgtact 2700
gtgtttttaa attttgtatg ccaatcttaa agacaaattt tgcatattct ctattttact 2760
tttctgccaa aataaacctg ttcttccttt tttaaaataa aataagttct taaaaaattt 2820
atacttaaaa aatcctgccc aaaatgtgaa gcttggttga ctgatgttca tgatagaaag 2880
aataaaatgt ttctctctct ctacctttta aaattgaata gtttatttct gtgaaagaag 2940
tatttaaact ttcaatattt taactttttg tttttatttc ttttagaaaa ggccaatata 3000
cctatcacac tttggaagta aaaatacaca ctttcgtgtg tacctaaaaa aaaaatcgtt 3060
gaaaatcaag gccaaaggta gtgcaatttt ttcattaaga tttaaaaaaa agggaatgat 3120
agtctttgaa agaaaacagt aggcatccag cactggacaa aacatgggta tcaaagatga 3180
ataatctttg gagattctgg cagtgttttc ccagaacaag tcaagtggaa agtggagaaa 3240
ttatctgtat aattttggac acatacaatg cagtt 3275
<210> 216
<211> 2381
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2381)
<223> HBEGF mRNA
<400> 216
attcggccga aggagctacg cgggccacgc tgctggctgg cctgacctag gcgcgcgggg 60
tcgggcggcc gcgcgggcgg gctgagtgag caagacaaga cactcaagaa gagcgagctg 120
cgcctgggtc ccggccaggc ttgcacgcag aggcgggcgg cagacggtgc ccggcggaat 180
ctcctgagct ccgccgccca gctctggtgc cagcgcccag tggccgccgc ttcgaaagtg 240
actggtgcct cgccgcctcc tctcggtgcg ggaccatgaa gctgctgccg tcggtggtgc 300
tgaagctctt tctggctgca gttctctcgg cactggtgac tggcgagagc ctggagcggc 360
ttcggagagg gctagctgct ggaaccagca acccggaccc tcccactgta tccacggacc 420
agctgctacc cctaggaggc ggccgggacc ggaaagtccg tgacttgcaa gaggcagatc 480
tggacctttt gagagtcact ttatcctcca agccacaagc actggccaca ccaaacaagg 540
aggagcacgg gaaaagaaag aagaaaggca aggggctagg gaagaagagg gacccatgtc 600
ttcggaaata caaggacttc tgcatccatg gagaatgcaa atatgtgaag gagctccggg 660
ctccctcctg catctgccac ccgggttacc atggagagag gtgtcatggg ctgagcctcc 720
cagtggaaaa tcgcttatat acctatgacc acacaaccat cctggccgtg gtggctgtgg 780
tgctgtcatc tgtctgtctg ctggtcatcg tggggcttct catgtttagg taccatagga 840
gaggaggtta tgatgtggaa aatgaagaga aagtgaagtt gggcatgact aattcccact 900
gagagagact tgtgctcaag gaatcggctg gggactgcta cctctgagaa gacacaaggt 960
gatttcagac tgcagagggg aaagacttcc atctagtcac aaagactcct tcgtccccag 1020
ttgccgtcta ggattgggcc tcccataatt gctttgccaa aataccagag ccttcaagtg 1080
ccaaacagag tatgtccgat ggtatctggg taagaagaaa gcaaaagcaa gggaccttca 1140
tgcccttctg attcccctcc accaaacccc acttcccctc ataagtttgt ttaaacactt 1200
atcttctgga ttagaatgcc ggttaaattc catatgctcc aggatctttg actgaaaaaa 1260
aaaaagaaga agaagaagga gagcaagaag gaaagatttg tgaactggaa gaaagcaaca 1320
aagattgaga agccatgtac tcaagtacca ccaagggatc tgccattggg accctccagt 1380
gctggatttg atgagttaac tgtgaaatac cacaagcctg agaactgaat tttgggactt 1440
ctacccagat ggaaaaataa caactatttt tgttgttgtt gtttgtaaat gcctcttaaa 1500
ttatatattt attttattct atgtatgtta atttatttag tttttaacaa tctaacaata 1560
atatttcaag tgcctagact gttactttgg caatttcctg gccctccact cctcatcccc 1620
acaatctggc ttagtgccac ccacctttgc cacaaagcta ggatggttct gtgacccatc 1680
tgtagtaatt tattgtctgt ctacatttct gcagatcttc cgtggtcaga gtgccactgc 1740
gggagctctg tatggtcagg atgtaggggt taacttggtc agagccactc tatgagttgg 1800
acttcagtct tgcctaggcg attttgtcta ccatttgtgt tttgaaagcc caaggtgctg 1860
atgtcaaagt gtaacagata tcagtgtctc cccgtgtcct ctccctgcca agtctcagaa 1920
gaggttgggc ttccatgcct gtagctttcc tggtccctca cccccatggc cccaggccca 1980
cagcgtggga actcactttc ccttgtgtca agacatttct ctaactcctg ccattcttct 2040
ggtgctactc catgcagggg tcagtgcagc agaggacagt ctggagaagg tattagcaaa 2100
gcaaaaggct gagaaggaac agggaacatt ggagctgact gttcttggta actgattacc 2160
tgccaattgc taccgagaag gttggaggtg gggaaggctt tgtataatcc cacccacctc 2220
accaaaacga tgaagttatg ctgtcatggt cctttctgga agtttctggt gccatttctg 2280
aactgttaca acttgtattt ccaaacctgg ttcatattta tactttgcaa tccaaataaa 2340
gataaccctt attccataaa aaaaaaaaaa aaaaaaaaaa a 2381
<210> 217
<211> 5834
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(5834)
<223> HGF mRNA
<400> 217
aggcactgac tccgaacagg attctttcac ccaggcatct cctccagagg gatccgccag 60
cccgtccagc agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt 120
cctcctgcat ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag 180
aagaaataca attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc 240
agcactgaag ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac 300
taggaataaa ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca 360
atgcctctgg ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga 420
atttgacctc tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag 480
ctacaaggga acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat 540
gataccacac gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa 600
ctactgtcga aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga 660
ggtacgctac gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa 720
tggggagagt tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg 780
ggatcatcag acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt 840
tgatgataat tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga 900
ccctcacacc cgctgggagt actgtgcaat taaaacatgc gctgacaata ctatgaatga 960
cactgatgtt cctttggaaa caactgaatg catccaaggt caaggagaag gctacagggg 1020
cactgtcaat accatttgga atggaattcc atgtcagcgt tgggattctc agtatcctca 1080
cgagcatgac atgactcctg aaaatttcaa gtgcaaggac ctacgagaaa attactgccg 1140
aaatccagat gggtctgaat caccctggtg ttttaccact gatccaaaca tccgagttgg 1200
ctactgctcc caaattccaa actgtgatat gtcacatgga caagattgtt atcgtgggaa 1260
tggcaaaaat tatatgggca acttatccca aacaagatct ggactaacat gttcaatgtg 1320
ggacaagaac atggaagact tacatcgtca tatcttctgg gaaccagatg caagtaagct 1380
gaatgagaat tactgccgaa atccagatga tgatgctcat ggaccctggt gctacacggg 1440
aaatccactc attccttggg attattgccc tatttctcgt tgtgaaggtg ataccacacc 1500
tacaatagtc aatttagacc atcccgtaat atcttgtgcc aaaacgaaac aattgcgagt 1560
tgtaaatggg attccaacac gaacaaacat aggatggatg gttagtttga gatacagaaa 1620
taaacatatc tgcggaggat cattgataaa ggagagttgg gttcttactg cacgacagtg 1680
tttcccttct cgagacttga aagattatga agcttggctt ggaattcatg atgtccacgg 1740
aagaggagat gagaaatgca aacaggttct caatgtttcc cagctggtat atggccctga 1800
aggatcagat ctggttttaa tgaagcttgc caggcctgct gtcctggatg attttgttag 1860
tacgattgat ttacctaatt atggatgcac aattcctgaa aagaccagtt gcagtgttta 1920
tggctggggc tacactggat tgatcaacta tgatggccta ttacgagtgg cacatctcta 1980
tataatggga aatgagaaat gcagccagca tcatcgaggg aaggtgactc tgaatgagtc 2040
tgaaatatgt gctggggctg aaaagattgg atcaggacca tgtgaggggg attatggtgg 2100
cccacttgtt tgtgagcaac ataaaatgag aatggttctt ggtgtcattg ttcctggtcg 2160
tggatgtgcc attccaaatc gtcctggtat ttttgtccga gtagcatatt atgcaaaatg 2220
gatacacaaa attattttaa catataaggt accacagtca tagctgaagt aagtgtgtct 2280
gaagcaccca ccaatacaac tgtcttttac atgaagattt cagagaatgt ggaatttaaa 2340
atgtcactta caacaatcct aagacaacta ctggagagtc atgtttgttg aaattctcat 2400
taatgtttat gggtgttttc tgttgttttg tttgtcagtg ttattttgtc aatgttgaag 2460
tgaattaagg tacatgcaag tgtaataaca tatctcctga agatacttga atggattaaa 2520
aaaacacaca ggtatatttg ctggatgata aagatttcat gggaaaaaaa atcaattaat 2580
ctgtctaagc tgctttctga tgttggtttc ttaataatga gtaaaccaca aattaaatgt 2640
tattttaacc tcaccaaaac aatttatacc ttgtgtccct aaattgtagc cctatattaa 2700
attatattac atttcatatg ctatatgtta tagttcattc atttctcttc accatgtatc 2760
ctgcaatact ggtacacgaa cacacttttt acaaaaccac atacccatgt acacatgcct 2820
aggtacacat gtgcatgcac tacagtttaa attatggtgt acctaatgta acccctaaat 2880
attttagaag tatgtaccta tagttttacc tcaaaaaaac cagaaatctc taaagaccag 2940
tagaaatatt aaaaaatgat gcaagatcaa aatgattagc taattctcca tacataatct 3000
gcagatgatc ttctttggtt ggcatttcag gtgtggccat cacccagagt taaataacac 3060
ctaatctagg tgtttacatg tattcattat cctagttatt tcatgtagtt tctaattctt 3120
aaaggaaaga gggtaatagt tctatttgtg taatttgttt cctccaaact taaggccact 3180
tatttacaca agatatttgt agatctattt tcctaaagca tttcttaagt gctcagatca 3240
gtatctaatt gaagaagttt aaaagtgttt tggtcattaa aaatgtactt aaataggtta 3300
aatctaagcc ttgctgctgt gattggcttc tagctcactg cctttaaatt ttaaaaaatt 3360
taagaggaaa atttccaagt ctccaaagtt ttataaatac ccttcatcaa gtcatgcatt 3420
aaagtatata ttggagaaaa aaataaaaat acttttctca acctggaaga ttttagccta 3480
ataaagcttt tttgaagtaa aagacaactt gtaaaaggaa agaaactagt ttgtctcaac 3540
tctgtattca tttatttttt ttttgaagta gagtggaatc tgttgaatca gatattttat 3600
caagatatgt ttattttttc ttatttcatt ttacaaagtt cactcctaat gccatatgta 3660
acagacattt aaattttgtg ttctgtataa cagccaaatt atcatattta tcattgtatt 3720
tgtcatgctt agctaaagat catgtatttg ttgagaaata gaataacaaa aagtaatagg 3780
ataggctttg aatttttgca gaaatcttcc tgtacaaaac acctttaaaa ataatttttt 3840
gaatggtgtg aatccagtag tcccatttct ctgacttagt tttcttgagt gatttttatc 3900
aaggccaagt ccccaaacaa ttccctacca gctctttaga gtactgttca atctggacta 3960
aaatggtttt aagtttatgg agagcttagt ccacagaata tagggcggcg agtccagaaa 4020
tgcttataca attttttttt cataataaga tatgtgctgg catcaagaaa cttaaagtgg 4080
aagcaaaaag acatccaact agttgctggt ctctatcatc ttatctgatg gtatttctat 4140
tttccttata taatacacca ttttagtaag aactcctaga aatttcaaga gcatattgcc 4200
aaaatataaa gtatatttca tagtttcttc tggctgaacc agtgaaattt tattattgca 4260
tattaatgat atttgtaaaa cttttataaa aattgtcata attttaaata ctcacatttt 4320
aaaaatactt ctttaatgac tcttcctcta aatttcctgg aaatacagat aaagattagc 4380
tagatacaag atacagctaa gtatttagac attttgaggc tagtattttt cattttatta 4440
aaggctaaaa acaataccac caataaatca tcaaacaaac cgtacaaagt aattctctct 4500
ttgggaggct cctttcgtga tagagggaca tgggtggaat tgacaatgaa acttagatga 4560
acaaggtcca tgttatttta ggtggtagaa cagggtagag tcatgtcatt atttgctggt 4620
ggaagacact atttaccagg tgttctttgc tgaataaatc attaaacatt tttaaaaatc 4680
caacaatcca ctttattttg tgtcattgac aaaaggatct tttaaatcag aaggtttcaa 4740
tgcaattttt ggtttggctg tttgaataat ggttatgtac tgttataatt gtagacattt 4800
tctcacgtct accaggaatt gaagtgtaaa actaaaatat ttttcataat gcctctgccg 4860
tgcagaagga atgataatcc ttttgtatac ttctttaatt ttattgtaaa atgtgtaatg 4920
acttttacct atatgctgtg ggcaggtcct cagtaaaatc tattgagtca atttctagta 4980
ttaacaggct tttgcttgct atctaagtgt ttcaaattat gggaagtgtg agacactgga 5040
aggcaagaaa attaacaata atggcatgtg atagcaaaat tgtatttcac ttattcctgt 5100
gaatatttct tgttggtacc aatggtactg tacaaagtga atgttatagc cacaacattc 5160
tcttgaaaag aacactgtca agaagtggga aattgctgtc aggcatttca ttgttgtttt 5220
taaacttttt taaaagaaat actggttttg caatatagag atcatgtggt aaagaatttt 5280
aataagatct tatactaaaa agccttaaat caatttattg agattcaaaa aatactatta 5340
taattaatta catcccatac atataggcaa actcatttaa aaaataaaac taattttggt 5400
aaaagtacat ggcctttgtt tttaaaatac ataattttaa aataaatcac ttgtcatgat 5460
aaagtccaaa aagaagttat cattcaacat tcaactaagg ttggagctaa gaatttacta 5520
atacaaaaaa agttaaaatt ttttggacca tatatatctt gacagtgtaa cttttaagta 5580
ggttcatttc catttgcaca gaaagtttct gtctttagga aactgaaaat gaaatactgt 5640
ggatgctatg actgtttgtc ttgtatgtaa ataggaaatt aataagctgc ctattgagtg 5700
gtatagctgt atgcttaccc aaaaaaggga acactgtggt tatgacttgt attataaact 5760
ttctgtagtt aataaagttg ttatttttat aaccatgatt atattattat tattaataaa 5820
atattttatc aaaa 5834
<210> 218
<211> 4150
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4150)
<223> HMGA2 mRNA
<400> 218
cttgaatctt ggggcaggaa ctcagaaaac ttccagcccg ggcagcgcgc gcttggtgca 60
agactcagga gctagcagcc cgtccccctc cgactctccg gtgccgccgc tgcctgctcc 120
cgccacccta ggaggcgcgg tgccacccac tactctgtcc tctgcctgtg ctccgtgccc 180
gaccctatcc cggcggagtc tccccatcct cctttgcttt ccgactgccc aaggcacttt 240
caatctcaat ctcttctctc tctctctctc tctctctctc tctctctctc tctctctctc 300
tctctctctc gcagggtggg gggaagagga ggaggaattc tttccccgcc taacatttca 360
agggacacaa ttcactccaa gtctcttccc tttccaagcc gcttccgaag tgctcccggt 420
gcccgcaact cctgatccca acccgcgaga ggagcctctg cgacctcaaa gcctctcttc 480
cttctccctc gcttccctcc tcctcttgct acctccacct ccaccgccac ctccacctcc 540
ggcacccacc caccgccgcc gccgccaccg gcagcgcctc ctcctctcct cctcctcctc 600
ccctcttctc tttttggcag ccgctggacg tccggtgttg atggtggcag cggcggcagc 660
ctaagcaaca gcagccctcg cagcccgcca gctcgcgctc gccccgccgg cgtccccagc 720
cctatcacct catctcccga aaggtgctgg gcagctccgg ggcggtcgag gcgaagcggc 780
tgcagcggcg gtagcggcgg cgggaggcag gatgagcgca cgcggtgagg gcgcggggca 840
gccgtccact tcagcccagg gacaacctgc cgccccagcg cctcagaaga gaggacgcgg 900
ccgccccagg aagcagcagc aagaaccaac cggtgagccc tctcctaaga gacccagggg 960
aagacccaaa ggcagcaaaa acaagagtcc ctctaaagca gctcaaaaga aagcagaagc 1020
cactggagaa aaacggccaa gaggcagacc taggaaatgg ccacaacaag ttgttcagaa 1080
gaagcctgct caggaggaaa ctgaagagac atcctcacaa gagtctgccg aagaggacta 1140
gggggcgcca acgttcgatt tctacctcag cagcagttgg atcttttgaa gggagaagac 1200
actgcagtga ccacttattc tgtattgcca tggtctttcc actttcatct ggggtggggt 1260
ggggtggggt gggggagggg ggggtggggt ggggagaaat cacataacct taaaaaggac 1320
tatattaatc accttctttg taatcccttc acagtcccag gtttagtgaa aaactgctgt 1380
aaacacaggg gacacagctt aacaatgcaa cttttaatta ctgttttctt ttttcttaac 1440
ctactaatag tttgttgatc tgataagcaa gagtgggcgg gtgagaaaaa ccgaattggg 1500
tttagtcaat cactgcactg catgcaaaca agaaacgtgt cacacttgtg acgtcgggca 1560
ttcatatagg aagaacgcgg tgtgtaacac tgtgtacacc tcaaatacca ccccaaccca 1620
ctccctgtag tgaatcctct gtttagaaca ccaaagataa ggactagata ctactttctc 1680
tttttcgtat aatcttgtag acacttactt gatgattttt aactttttat ttctaaatga 1740
gacgaaatgc tgatgtatcc tttcattcag ctaacaaact agaaaaggtt atgttcattt 1800
ttcaaaaagg gaagtaagca aacaaatatt gccaactctt ctatttatgg atatcacaca 1860
tatcagcagg agtaataaat ttactcacag cacttgtttt caggacaaca cttcattttc 1920
aggaaatcta cttcctacag agccaaaatg ccatttagca ataaataaca cttgtcagcc 1980
tcagagcatt taaggaaact agacaagtaa aattatcctc tttgtaattt aatgaaaagg 2040
tacaacagaa taatgcatga tgaactcacc taattatgag gtgggaggag cgaaatctaa 2100
atttcttttg ctatagttat acatcaattt aaaaagcaaa aaaaaaaaag gggggggcaa 2160
tctctctctg tgtctttctc tctctctctt cctctccctc tctcttttca ttgtgtatca 2220
gtttccatga aagacctgaa taccacttac ctcaaattaa gcatatgtgt tacttcaagt 2280
aatacgtttt gacataagat ggttgaccaa ggtgcttttc ttcggcttga gttcaccatc 2340
tcttcattca aactgcactt ttagccagag atgcaatata tccccactac tcaatactac 2400
ctctgaatgt tacaacgaat ttacagtcta gtacttatta catgctgcta tacacaagca 2460
atgcaagaaa aaaacttact gggtaggtga ttctaatcat ctgcagttct ttttgtacac 2520
ttaattacag ttaaagaagc aatctcctta ctgtgtttca gcatgactat gtatttttct 2580
atgttttttt aattaaaaat ttttaaaata cttgtttcag cttctctgct agatttctac 2640
attaacttga aaatttttta accaagtcgc tcctaggttc ttaaggataa ttttcctcaa 2700
tcacactaca catcacacaa gatttgactg taatatttaa atattaccct ccaagtctgt 2760
acctcaaatg aattctttaa ggagatggac taattgactt gcaaagacct acctccagac 2820
ttcaaaagga atgaacttgt tacttgcagc attcatttgt tttttcaatg tttgaaatag 2880
ttcaaactgc agctaaccct agtcaaaact atttttgtaa aagacatttg atagaaagga 2940
acacgttttt acatactttt gcaaaataag taaataataa ataaaataaa agccaacctt 3000
caaagaaact tgaagctttg taggtgagat gcaacaagcc ctgcttttgc ataatgcaat 3060
caaaaatatg tgtttttaag attagttgaa tataagaaaa tgcttgacaa atattttcat 3120
gtattttaca caaatgtgat ttttgtaata tgtctcaacc agatttattt taaacgcttc 3180
ttatgtagag tttttatgcc tttctctcct agtgagtgtg ctgacttttt aacatggtat 3240
tatcaactgg gccaggaggt agtttctcat gacggctttt gtcagtatgg cttttagtac 3300
tgaagccaaa tgaaactcaa aaccatctct cttccagctg cttcagggag gtagtttcaa 3360
aggccacata cctctctgag actggcagat cgctcactgt tgtgaatcac caaaggagct 3420
atggagagaa ttaaaactca acattactgt taactgtgcg ttaaataagc aaataaacag 3480
tggctcataa aaataaaagt cgcattccat atctttggat gggcctttta gaaacctcat 3540
tggccagctc ataaaatgga agcaattgct catgttggcc aaacatggtg caccgagtga 3600
tttccatctc tggtaaagtt acacttttat ttcctgtatg ttgtacaatc aaaacacact 3660
actacctctt aagtcccagt atacctcatt tttcatactg aaaaaaaaag cttgtggcca 3720
atggaacagt aagaacatca taaaattttt atatatatag tttatttttg tgggagataa 3780
attttatagg actgttcttt gctgttgttg gtcgcagcta cataagactg gacatttaac 3840
ttttctacca tttctgcaag ttaggtatgt ttgcaggaga aaagtatcaa gacgtttaac 3900
tgcagttgac tttctccctg ttcctttgag tgtcttctaa ctttattctt tgttctttat 3960
gtagaattgc tgtctatgat tgtactttga atcgcttgct tgttgaaaat atttctctag 4020
tgtattatca ctgtctgttc tgcacaataa acataacagc ctctgtgatc cccatgtgtt 4080
ttgattcctg ctctttgtta cagttccatt aaatgagtaa taaagtttgg tcaaaacaga 4140
aaaaaaaaaa 4150
<210> 219
<211> 2967
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2967)
<223> ICAM1 mRNA
<400> 219
gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg 60
gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc 120
ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac 180
atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa 240
ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga 300
tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct 360
caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt 420
gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac 480
cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc 540
tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg 600
cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta 660
ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct 720
agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga 780
ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa 840
cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg 900
gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat 960
ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga 1020
ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc 1080
ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg 1140
cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac 1200
ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg 1260
gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc 1320
cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt 1380
cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac 1440
ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt 1500
agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg 1560
gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac 1620
acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat 1680
tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac 1740
cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg 1800
ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta 1860
agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat 1920
gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac 1980
tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct 2040
ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg 2100
ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta 2160
ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg 2220
gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg 2280
caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc 2340
tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt 2400
tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc 2460
tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg 2520
gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc 2580
tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt 2640
cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc 2700
ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct 2760
ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc 2820
tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat 2880
ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg 2940
ttagttaata aagctttctc aactgcc 2967
<210> 220
<211> 1237
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1237)
<223> IER3 mRNA
<400> 220
acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca 60
tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct 120
ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc 180
gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggttctctac cctcgagtgg 240
tccggcgcca gctgccagtc gaggaaccga acccagccaa aaggcttctc tttctgctgc 300
tcaccatcgt cttctgccag atcctgatgg ctgaagaggg tgtgccggcg cccctgcctc 360
cagaggacgc ccctaacgcc gcatccctgg cgcccacccc tgtgtccgcc gtcctcgagc 420
cctttaatct gacttcggag ccctcggact acgctctgga cctcagcact ttcctccagc 480
aacacccggc cgccttctaa ctgtgactcc ccgcactccc caaaaagaat ccgaaaaacc 540
acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg gacttccgag 600
gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg cgggaccgag 660
gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc taggcccggt 720
gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt atatgtattt 780
atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac ttatgcaagg 840
gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga gctttgtggg 900
actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg gggaggactc 960
gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa gtttaggagg 1020
tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt cggcggacca 1080
ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag ggtggctgcg 1140
aggtagaggg ttgggggttg gtgggctgtc acggagcgac tgtcgagatc gcctagtatg 1200
ttctgtgaac acaaataaaa ttgatttact gtctgca 1237
<210> 221
<211> 1376
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1376)
<223> IL-13RA2 mRNA
<400> 221
gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata 60
acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg 120
gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa 180
catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg 240
agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc 300
tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg 360
aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca 420
agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag 480
ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta 540
aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac 600
ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg 660
atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat 720
ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag 780
agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt 840
tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga 900
gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag 960
atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa 1020
atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg 1080
acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga 1140
aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa 1200
ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg 1260
atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg 1320
ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa 1376
<210> 222
<211> 2718
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2718)
<223> IL-33 mRNA
<400> 222
agtctacaga ctcctccgaa cacagagctg cagctcttca gggaagaaat caaaacaaga 60
tcacaagaat actgaaaaat gaagcctaaa atgaagtatt caaccaacaa aatttccaca 120
gcaaagtgga agaacacagc aagcaaagcc ttgtgtttca agctgggaaa atcccaacag 180
aaggccaaag aagtttgccc catgtacttt atgaagctcc gctctggcct tatgataaaa 240
aaggaggcct gttactttag gagagaaacc accaaaaggc cttcactgaa aacaggtaga 300
aagcacaaaa gacatctggt actcgctgcc tgtcaacagc agtctactgt ggagtgcttt 360
gcctttggta tatcaggggt ccagaaatat actagagcac ttcatgattc aagtatcaca 420
ggaatttcac ctattacaga gtatcttgct tctctaagca catacaatga tcaatccatt 480
acttttgctt tggaggatga aagttatgag atatatgttg aagacttgaa aaaagatgaa 540
aagaaagata aggtgttact gagttactat gagtctcaac acccctcaaa tgaatcaggt 600
gacggtgttg atggtaagat gttaatggta accctgagtc ctacaaaaga cttctggttg 660
catgccaaca acaaggaaca ctctgtggag ctccataagt gtgaaaaacc actgccagac 720
caggccttct ttgtccttca taatatgcac tccaactgtg tttcatttga atgcaagact 780
gatcctggag tgtttatagg tgtaaaggat aatcatcttg ctctgattaa agtagactct 840
tctgagaatt tgtgtactga aaatatcttg tttaagctct ctgaaactta gttgatggaa 900
acctgtgagt cttgggttga gtacccaaat gctaccactg gagaaggaat gagagataaa 960
gaaagagaca ggtgacatct aagggaaatg aagagtgctt agcatgtgtg gaatgttttc 1020
catattatgt ataaaaatat tttttctaat cctccagtta ttcttttatt tccctctgta 1080
taactgcatc ttcaatacaa gtatcagtat attaaatagg gtattggtaa agaaacggtc 1140
aacattctaa agagatacag tctgaccttt acttttctct agtttcagtc cagaaagaac 1200
ttcatattta gagctaaggc cactgaggaa agagccatag cttaagtctc tatgtagaca 1260
gggatccatt ttaaagagct acttagagaa ataattttcc acagttccaa acgataggct 1320
caaacactag agctgctagt aaaaagaaga ccagatgctt cacagaatta tcattttttc 1380
aactggaata aaacaccagg tttgtttgta gatgtcttag gcaacactca gagcagatct 1440
cccttactgt caggggatat ggaacttcaa aggcccacat ggcaagccag gtaacataaa 1500
tgtgtgaaaa agtaaagata actaaaaaat ttagaaaaat aaatccagta tttgtaaagt 1560
gaataacttc atttctaatt gtttaatttt taaaattctg atttttatat attgagttta 1620
agcaaggcat tcttacacga ggaagtgaag taaattttag ttcagacata aaatttcact 1680
tattaggaat atgtaacatg ctaaaacttt ttttttttta aagagtactg agtcacaaca 1740
tgttttagag catccaagta ccatataatc caactatcat ggtaaggcca gaaatcttct 1800
aacctaccag agcctagatg agacaccgaa ttaacattaa aatttcagta actgactgtc 1860
cctcatgtcc atggcctacc atcccttctg accctggctt ccagggacct atgtctttta 1920
atactcactg tcacattggg caaagttgct tctaatcctt atttcccatg tgcacaagtc 1980
tttttgtatt ccagcttcct gataacactg cttactgtgg aatattcatt tgacatctgt 2040
ctcttttcat ttcttttaac taccatgccc ttgatatatc ttttgcacct gctgaacttc 2100
atttctgtat cacctgacct ctggatgcca aaacgtttat tctgctttgt ctgttgtaga 2160
attttagata aagctattaa tggcaatatt tttttgctaa acgtttttgt tttttactgt 2220
cactagggca ataaaattta tactcaacca tataataaca ttttttaact actaaaggag 2280
tagtttttat tttaaagtct tagcaatttc tattacaact tttcttagac ttaacactta 2340
tgataaatga ctaacatagt aacagaatct ttatgaaata tgaccttttc tgaaaataca 2400
tacttttaca tttctacttt attgagacct attagatgta agtgctagta gaatataaga 2460
taaaagaggc tgagaattac catacaaggg tattacaact gtaaaacaat ttatctttgt 2520
ttcattgttc tgtcaataat tgttaccaaa gagataaaaa taaaagcaga atgtatatca 2580
tcccatctga aaaacactaa ttattgacat gtgcatctgt acaataaact taaaatgatt 2640
attaaataat caaatatatc tactacattg tttatattat tgaataaagt atattttcca 2700
aatgtaaaaa aaaaaaaa 2718
<210> 223
<211> 1498
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1498)
<223> IL-1B mRNA
<400> 223
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc 60
ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg 120
atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag 180
atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga 240
atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg 300
gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc 360
accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag 420
gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa 480
aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat 540
atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa 600
atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat 660
gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg 720
gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc 780
cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga 840
gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga 900
gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag 960
ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg 1020
cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc 1080
agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc 1140
tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc 1200
tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt 1260
ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt 1320
aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt 1380
taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat 1440
atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag 1498
<210> 224
<211> 1197
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1197)
<223> IL-6 mRNA
<400> 224
gtctcaatat tagagtctca acccccaata aatataggac tggagatgtc tgaggctcat 60
tctgccctcg agcccaccgg gaacgaaaga gaagctctat ctcccctcca ggagcccagc 120
tatgaactcc ttctccacaa gcgccttcgg tccagttgcc ttctccctgg ggctgctcct 180
ggtgttgcct gctgccttcc ctgccccagt acccccagga gaagattcca aagatgtagc 240
cgccccacac agacagccac tcacctcttc agaacgaatt gacaaacaaa ttcggtacat 300
cctcgacggc atctcagccc tgagaaagga gacatgtaac aagagtaaca tgtgtgaaag 360
cagcaaagag gcactggcag aaaacaacct gaaccttcca aagatggctg aaaaagatgg 420
atgcttccaa tctggattca atgaggagac ttgcctggtg aaaatcatca ctggtctttt 480
ggagtttgag gtatacctag agtacctcca gaacagattt gagagtagtg aggaacaagc 540
cagagctgtg cagatgagta caaaagtcct gatccagttc ctgcagaaaa aggcaaagaa 600
tctagatgca ataaccaccc ctgacccaac cacaaatgcc agcctgctga cgaagctgca 660
ggcacagaac cagtggctgc aggacatgac aactcatctc attctgcgca gctttaagga 720
gttcctgcag tccagcctga gggctcttcg gcaaatgtag catgggcacc tcagattgtt 780
gttgttaatg ggcattcctt cttctggtca gaaacctgtc cactgggcac agaacttatg 840
ttgttctcta tggagaacta aaagtatgag cgttaggaca ctattttaat tatttttaat 900
ttattaatat ttaaatatgt gaagctgagt taatttatgt aagtcatatt tatattttta 960
agaagtacca cttgaaacat tttatgtatt agttttgaaa taataatgga aagtggctat 1020
gcagtttgaa tatcctttgt ttcagagcca gatcatttct tggaaagtgt aggcttacct 1080
caaataaatg gctaacttat acatattttt aaagaaatat ttatattgta tttatataat 1140
gtataaatgg tttttatacc aataaatggc attttaaaaa attcagcaaa aaaaaaa 1197
<210> 225
<211> 9027
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(9027)
<223> IL-6ST mRNA
<400> 225
ggatctgaca gtgttccgga gccggggcga gcagccaaaa ggcccgcgga gtcgcgctgg 60
gccgccccgg cgcagctgaa ccgggggccg cgcctgccag gccgacgggt ctggcccagc 120
ctggcgccaa ggggttcgtg cgctgtggag acgcggaggg tcgaggcggc gcggcctgag 180
tgaaacccaa tggaaaaagc atgacattta gaagtagaag acttagcttc aaatccctac 240
tccttcactt actaattttg tgatttggaa atatccgcgc aagatgttga cgttgcagac 300
ttggctagtg caagccttgt ttattttcct caccactgaa tctacaggtg aacttctaga 360
tccatgtggt tatatcagtc ctgaatctcc agttgtacaa cttcattcta atttcactgc 420
agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat gtaaatgcta attacattgt 480
ctggaaaaca aaccatttta ctattcctaa ggagcaatat actatcataa acagaacagc 540
atccagtgtc acctttacag atatagcttc attaaatatt cagctcactt gcaacattct 600
tacattcgga cagcttgaac agaatgttta tggaatcaca ataatttcag gcttgcctcc 660
agaaaaacct aaaaatttga gttgcattgt gaacgagggg aagaaaatga ggtgtgagtg 720
ggatggtgga agggaaacac acttggagac aaacttcact ttaaaatctg aatgggcaac 780
acacaagttt gctgattgca aagcaaaacg tgacaccccc acctcatgca ctgttgatta 840
ttctactgtg tattttgtca acattgaagt ctgggtagaa gcagagaatg cccttgggaa 900
ggttacatca gatcatatca attttgatcc tgtatataaa gtgaagccca atccgccaca 960
taatttatca gtgatcaact cagaggaact gtctagtatc ttaaaattga catggaccaa 1020
cccaagtatt aagagtgtta taatactaaa atataacatt caatatagga ccaaagatgc 1080
ctcaacttgg agccagattc ctcctgaaga cacagcatcc acccgatctt cattcactgt 1140
ccaagacctt aaacctttta cagaatatgt gtttaggatt cgctgtatga aggaagatgg 1200
taagggatac tggagtgact ggagtgaaga agcaagtggg atcacctatg aagatagacc 1260
atctaaagca ccaagtttct ggtataaaat agatccatcc catactcaag gctacagaac 1320
tgtacaactc gtgtggaaga cattgcctcc ttttgaagcc aatggaaaaa tcttggatta 1380
tgaagtgact ctcacaagat ggaaatcaca tttacaaaat tacacagtta atgccacaaa 1440
actgacagta aatctcacaa atgatcgcta tctagcaacc ctaacagtaa gaaatcttgt 1500
tggcaaatca gatgcagctg ttttaactat ccctgcctgt gactttcaag ctactcaccc 1560
tgtaatggat cttaaagcat tccccaaaga taacatgctt tgggtggaat ggactactcc 1620
aagggaatct gtaaagaaat atatacttga gtggtgtgtg ttatcagata aagcaccctg 1680
tatcacagac tggcaacaag aagatggtac cgtgcatcgc acctatttaa gagggaactt 1740
agcagagagc aaatgctatt tgataacagt tactccagta tatgctgatg gaccaggaag 1800
ccctgaatcc ataaaggcat accttaaaca agctccacct tccaaaggac ctactgttcg 1860
gacaaaaaaa gtagggaaaa acgaagctgt cttagagtgg gaccaacttc ctgttgatgt 1920
tcagaatgga tttatcagaa attatactat attttataga accatcattg gaaatgaaac 1980
tgctgtgaat gtggattctt cccacacaga atatacattg tcctctttga ctagtgacac 2040
attgtacatg gtacgaatgg cagcatacac agatgaaggt gggaaggatg gtccagaatt 2100
cacttttact accccaaagt ttgctcaagg agaaattgaa gccatagtcg tgcctgtttg 2160
cttagcattc ctattgacaa ctcttctggg agtgctgttc tgctttaata agcgagacct 2220
aattaaaaaa cacatctggc ctaatgttcc agatccttca aagagtcata ttgcccagtg 2280
gtcacctcac actcctccaa ggcacaattt taattcaaaa gatcaaatgt attcagatgg 2340
caatttcact gatgtaagtg ttgtggaaat agaagcaaat gacaaaaagc cttttccaga 2400
agatctgaaa tcattggacc tgttcaaaaa ggaaaaaatt aatactgaag gacacagcag 2460
tggtattggg gggtcttcat gcatgtcatc ttctaggcca agcatttcta gcagtgatga 2520
aaatgaatct tcacaaaaca cttcgagcac tgtccagtat tctaccgtgg tacacagtgg 2580
ctacagacac caagttccgt cagtccaagt cttctcaaga tccgagtcta cccagccctt 2640
gttagattca gaggagcggc cagaagatct acaattagta gatcatgtag atggcggtga 2700
tggtattttg cccaggcaac agtacttcaa acagaactgc agtcagcatg aatccagtcc 2760
agatatttca cattttgaaa ggtcaaagca agtttcatca gtcaatgagg aagattttgt 2820
tagacttaaa cagcagattt cagatcatat ttcacaatcc tgtggatctg ggcaaatgaa 2880
aatgtttcag gaagtttctg cagcagatgc ttttggtcca ggtactgagg gacaagtaga 2940
aagatttgaa acagttggca tggaggctgc gactgatgaa ggcatgccta aaagttactt 3000
accacagact gtacggcaag gcggctacat gcctcagtga aggactagta gttcctgcta 3060
caacttcagc agtacctata aagtaaagct aaaatgattt tatctgtgaa ttcagatttt 3120
aaaaagtctt cactctctga agatgatcat ttgcccttaa ggacaaaaat gaactgaagt 3180
ttcacatgag ctatttccat tccagaatat ctgggattct actttaagca ctacataaac 3240
tgactttatc ctcagactag ctgaatgatt ttgtgctgtt tcaggatgtt tgcactgaag 3300
aaaaacagaa agcttatctg aaatttataa aactttttgt tttgctacat agaaaacaga 3360
aggtatttga ataataagca gtgatatgct tagtgagcac agctatactg attttgatta 3420
gaatagtcat cagagtggct tagggacagt taatataaaa gaggagcaag gtgtagacca 3480
tcatctactt ctgctaaaat aacttaaaaa gaggtccata ggccataact acatgagccc 3540
agcttttgta atctgacaaa aaaatgagga gcagcttcgt gtatatcagt gtacacggta 3600
ttccttaggt cccttccatt ggtagtgatg ctgcgagtta ttactggaga aaaggaattc 3660
tagagcttta acttggcaga ttaaaagtac tcatttttta ttcatcaata attagtaatc 3720
tcactagttt tcaaaaattt gcatattatt gacaacctct ttgaagatgc atttcacaaa 3780
ctcaacagag tgccatgata agagctaggg atcccccaaa ctatctcaag catctaaaaa 3840
attgccattt ttaaaggctt aaattgtagt agtaaagggg aaaacaggaa gtagtagtaa 3900
aggggaaaaa aaaccaataa agcatctaaa aaattggcat gttaaaaggc ttaaattgct 3960
aatgtgtgta tatatatata tatatataca cacacatatc attgactttt cttaagactt 4020
cagagtactg ggtagatgaa cactttatac agtatatatc ttcagcttaa atttgttttg 4080
agtatttttt ttatttttaa ataagtaggc aaagatttaa atttttttat ttttagtaaa 4140
tgtttgaggc acactaagac aacttgggca atatttgcca aaacaaaaca gaaccccaaa 4200
aaatgtacat cttgttctta gcaaatatca ttattgtaga gacacttaat aaagagatgg 4260
tattttaatg tctgcagttc tgaggtaggg tggaacttag ttctacattg tgatttagga 4320
atttttaaaa ccttttttct tcaagggaga agtgacccag gcctcgagtt tagtgctaaa 4380
gccgctagtg tacttatgct gtcccctaac caccacgtgc gatatggaag cagatgctaa 4440
atataggggt tttcttagaa agtaagagga aattagcaag cgttattagt gattgactac 4500
tgctatcaag tgaattcaaa ggaaacaggt ttttatgcca tatttaagtt acagaaacca 4560
ggcatgctta gaatagtttc tagaggttat tggagaatag aaagctaaga aaacttggta 4620
tacatttaca atggaaatat aattacactt tttactctca gaatattgtt cacattagac 4680
ttcctgttta tcttttatat tcttgcattt atataatgcc tcatcctttc aaagttcttt 4740
cacatattat atgatcttct ttatgaaaaa aatagatgtt tcattctgat atattcagtt 4800
tcccacttta ggcaaaagta gattaataga atgacgaatt caaagtagat gaggaaaatc 4860
aggcacagag aagtaaaggt agggatagac ccaaatttac acaacaagat aatgacatct 4920
ccagctttta agttgatcat caaaggctgg gctggatttg tcttgctgta tgtgtcagga 4980
aatttatacc tattacattt tccattttct caaaatttaa gtcacatgac taatatttag 5040
ctgcaacttt cctcataaca aatagtgtca tgaagaatgt tgtagtgtga agtttgtaca 5100
tttcagggtc agatatacaa tatgaactct taatctacag gaatgagaat ggaggatcat 5160
tgaaggccat gatataaaca aatttgcatg ttgaagcctg tataaaacat ggtacagtga 5220
gtgaatatac ccccatcccc aagaacactt tatacatatt aaatggatat atgattactg 5280
tgcaaaaatt cattctggaa atgaacatat atttgagcac taatatgtaa tgtacacctg 5340
ccctaaggag aaaataaatt ataaaacttt ttacattcaa aattactttc ccaagcatgt 5400
cttagaataa tctatgtgtt gatgcatgta aattgtactt taggtaggca aagaaatctg 5460
gttatttatg taaaaactag tctaataaag ttagttagtg gctttatcac tttaaatctt 5520
tagtgtccaa aagtggtgtt taaagtaata gcacatcaga aaaccttgtc tggacaaaac 5580
tagttcactc actgcttctg cacctgcagt tgctcccttt agggttataa aataatgacc 5640
caaatgttac atgtgttgat attataactt gtcagttact gatgtctgtg gtatcctacc 5700
ctcatctctg aaagggataa tactgaataa ttattagaaa actataaaac ttcacacttt 5760
gtaccattaa aacctaaaat tttaatcttg tcctttttta ctatggatca gtcggcactc 5820
gggaacagca gcaaggaaaa aaagcaaatt tcattcacat gttctgtgtt catacctctt 5880
ctctacctaa ttgttcattt aaatttcagc cttattcctt gataagggat tttaccacat 5940
gaagtcatcc agtgacccta gctcttattg tgaagttagt ggagtatact tagaaatgtt 6000
acaactttaa aatgttacaa aacattcatt aaagctcata tttaaagtag agcatctagt 6060
ttgagaaata gaaatcaatt attaaagatg tcttttttct acccatttaa ctagttaaaa 6120
ccatgacatg taaatgtaga agtagaataa tcatagaatt ccctaaaata tttctgttta 6180
ctaacatata ttgaccaagt acatcaagca ggagagatct tccttcattc tgttatagtc 6240
cacatcattc taattttgct cagttgttat taagagcata ttcctaaacc atacactttt 6300
gtttcaataa agttttattt tgttgagatg aataaaataa caaagttata agctgcataa 6360
gacaaaagtt caattgttca aaaaaaattt actgggatag ctttctatta caggtattgt 6420
tagattatat tgtgctgata agattacttt ctaaaaaatt tgtacttttc tgtaaattaa 6480
aagaatatgg agtcataaaa tggcaagtgt tttaggatta gcctaaaatt ggacattgtc 6540
attgatttca aagaaggtat gaactagcag tcttacagcc taattcttct ttggactggt 6600
ccttggcagc agttcctttt cagactcgat aaacagaatt cagatgatgt aagtcaaaac 6660
aaaactttac aaagccaagc gtattatctt ttgcattaac ctattttttt ccatcataca 6720
tgctactagt atgtgcatta gcatgatatt ctcatataca ttgcattaaa aattaaaagg 6780
tggcagctca gggtgagctc ttctgttgct catttgttcc taaattttta agggcttttt 6840
ctcagtcaat agtttgtaca aactggttag tttaacttca ttacccattt cattaaagtt 6900
gatgggtcgt gtgatgagat gcatttaagg ccgatagtga tagatgtttt ttttatttct 6960
tgaacacagg ctttgtctga atgatgttct tttatctctt gaacacaagc tttgaatgat 7020
aactacaggt tttaagtgct gttacattaa taccataatg tgatgtgtta gaaacaaagg 7080
gatatttcaa aggtagatat ttgaaaattc tctagtctca atatgtatgt gtattgaata 7140
tactctaaaa ataaatgtgc aatttgctag taggacaatg cagtgactga ctagcattag 7200
gtatgtttct tttatatcct agctatgtcc cactttcttc taagtgcaat cctttcatgt 7260
tcacttgctg ttttacccca tctactctaa cttcatttgg aaggcttgtc tagagtatag 7320
catgtatttt tacctttgca gtgaattgca tgtgctaatt gtaaccacag ctatttttat 7380
gttgacataa ctccaaatgt tatattaaat gttctattat atattagctc taatccctta 7440
agtaaatttt aagaaataaa tacttgttca aatttttttt ctgtatgtgg ttactatcat 7500
ctgactatgc atatttgtaa cagcatttat cattagtggt gttagctaaa taagcatctt 7560
agtgtaaatg agatgcttcg tgtgggtttt gtgacatttt aaatgacata atggaatgtg 7620
atttaaaaga aaaccagtac actatcttgg tcttaataac atagaatgga gatggcaaat 7680
ttatccacta gttttccaga tttactattt aatagctgag gtctgaaatc gtagcatcct 7740
ccctcctagt ggacattaaa aaaaaaaaaa aaaaaaaaaa cctacttggt tgtcaagagc 7800
ccaagtatgg aggtgctgcg ccatcttgtg gcctgtctgt gcccaccctg cactctgctg 7860
gagtctccat ccttgttgca gtgagacttg aagttcaaga ttgatacatg gcatcctcct 7920
gctacttctt gaggttacta agtagtatat gaaactaatc agtcagcaag tccacctgga 7980
aggaaaagaa aatctcaact attaatgtgc cttcacattg tgattttgtc taaaaaaatg 8040
tagtgagtca aaaaacccac aagccagcca acagtaactc cttcacatat ataccagagt 8100
ttatagaaat aacatgtcag ctttgggcta tgtgctcctt tgtttaaaat cttctatttg 8160
gttatggctt gtataggctc aagcctgatt tctttaaggt gtggtggctc atcttatcct 8220
aatgtgtatg atagatacag tccatcctgc tttggaaaag attatgtaac tccttgagag 8280
catactcttt ctctagccca aaggcagtga gagagttttc ttgttcagga ttgcttaact 8340
ttccatttaa gctttttctt tttaaattaa tacaaacttc tacactttca aaatacgaaa 8400
tatattacaa ctgcgtatag gctcttccat acttaagtcc agtgcttggg caagttaatg 8460
gagtgaaaga ctacaagcaa agaggaactg aggtagaaaa agaagaatgt gtgaaagcag 8520
caggaagctc agccaactcg aaagcagggt gaacagcttg agtcctgttg ctgctgatcg 8580
gggttggctc ttggacaact tagtaagatc atggaaaggc tgcttgggtt ctccatagaa 8640
aagttctgtc tccatcaagg gaggaaaatg tacctttcaa ctcaaaattc aatatttgtt 8700
tttaaatata gctattttcc ccaaccgcta aagattttca acagatacga agccagagct 8760
tagttttaga aacctgtgga cattcaaacc tgattcttta ttccctgtga ctatggttat 8820
gtcattttac atgtcaaaaa agtgtatcta gaattgtcat ttcttatttt tgagcttttt 8880
ttagtgagaa ttatcccctc acttaaatgg ctttttattt aaacatctgt gcattctgta 8940
tgaaattgta gtctttctgg gataacatgg tgagctatat ggtggtaatc cacacacaca 9000
aaaataaaag ccaaaaaaaa accaaaa 9027
<210> 226
<211> 4643
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4643)
<223> IL-7R mRNA
<400> 226
gtggttagat aagtataaag ccctagatct aagcttctct gtcttcctcc ctccctccct 60
tcctcttact ctcattcatt tcatacacac tggctcacac atctactctc tctctctatc 120
tctctcagaa tgacaattct aggtacaact tttggcatgg ttttttcttt acttcaagtc 180
gtttctggag aaagtggcta tgctcaaaat ggagacttgg aagatgcaga actggatgac 240
tactcattct catgctatag ccagttggaa gtgaatggat cgcagcactc actgacctgt 300
gcttttgagg acccagatgt caacatcacc aatctggaat ttgaaatatg tggggccctc 360
gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga tatatttcat cgagacaaag 420
aaattcttac tgattggaaa gagcaatata tgtgtgaagg ttggagaaaa gagtctaacc 480
tgcaaaaaaa tagacctaac cactatagtt aaacctgagg ctccttttga cctgagtgtc 540
gtctatcggg aaggagccaa tgactttgtg gtgacattta atacatcaca cttgcaaaag 600
aagtatgtaa aagttttaat gcacgatgta gcttaccgcc aggaaaagga tgaaaacaaa 660
tggacgcatg tgaatttatc cagcacaaag ctgacactcc tgcagagaaa gctccaaccg 720
gcagcaatgt atgagattaa agttcgatcc atccctgatc actattttaa aggcttctgg 780
agtgaatgga gtccaagtta ttacttcaga actccagaga tcaataatag ctcaggggag 840
atggatccta tcttactaac catcagcatt ttgagttttt tctctgtcgc tctgttggtc 900
atcttggcct gtgtgttatg gaaaaaaagg attaagccta tcgtatggcc cagtctcccc 960
gatcataaga agactctgga acatctttgt aagaaaccaa gaaaaaattt aaatgtgagt 1020
ttcaatcctg aaagtttcct ggactgccag attcataggg tggatgacat tcaagctaga 1080
gatgaagtgg aaggttttct gcaagatacg tttcctcagc aactagaaga atctgagaag 1140
cagaggcttg gaggggatgt gcagagcccc aactgcccat ctgaggatgt agtcatcact 1200
ccagaaagct ttggaagaga ttcatccctc acatgcctgg ctgggaatgt cagtgcatgt 1260
gacgccccta ttctctcctc ttccaggtcc ctagactgca gggagagtgg caagaatggg 1320
cctcatgtgt accaggacct cctgcttagc cttgggacta caaacagcac gctgccccct 1380
ccattttctc tccaatctgg aatcctgaca ttgaacccag ttgctcaggg tcagcccatt 1440
cttacttccc tgggatcaaa tcaagaagaa gcatatgtca ccatgtccag cttctaccaa 1500
aaccagtgaa gtgtaagaaa cccagactga acttaccgtg agcgacaaag atgatttaaa 1560
agggaagtct agagttccta gtctccctca cagcacagag aagacaaaat tagcaaaacc 1620
ccactacaca gtctgcaaga ttctgaaaca ttgctttgac cactcttcct gagttcagtg 1680
gcactcaaca tgagtcaaga gcatcctgct tctaccatgt ggatttggtc acaaggttta 1740
aggtgaccca atgattcagc tatttaaaaa aaaaagagga aagaatgaaa gagtaaagga 1800
aatgattgag gagtgaggaa ggcaggaaga gagcatgaga ggaaagaaag aaaggaaaat 1860
aaaaaatgat agttgccatt attaggattt aatatatatc cagtgctttg caagtgctct 1920
gcgcaccttg tctcactcca tcctgacaat aatcctggga ggtgtgtgca attactacga 1980
ctactctctt ttttatagat cattaaattc agaactaagg agttaagtaa cttgtccaag 2040
ttgttcacac agtgaaggga ggggccaaga tatgatggct gggagtctaa ttgcagttcc 2100
ctgagccatg tgcctttctc ttcactgagg actgccccat tcttgagtgc caaacgtcac 2160
tagtaacagg gtgtgcctag ataatttatg atccaaactg agtcagtttg gaaagtgaaa 2220
gggaaactta catataatcc ctccgggaca atgagcaaaa actaggactg tccccagaca 2280
aatgtgaaca tacatatcat cacttaaatt aaaatggcta tgagaaagaa agagggggag 2340
aaacagtctt gcgggtgtga agtcccatga ccagccatgt caaaagaagg taaagaagtc 2400
aagaaaaagc catgaagccc atttggtttc atttttctga aaataggctc aagagggaat 2460
aaattagaaa ctcacaattt ctcttgtttg ttaccaagac agtgattctc ttgctgctac 2520
cacccaactg catccgtcca tgatctcaga ggaaactgtc gctgaccctg gacatgggta 2580
cgtttgacga gtgagaggag gcatgacccc tcccatgtgt atagacacta ccccaaccta 2640
aattcatccc taaattgtcc caagttctcc agcaatagag gctgccacaa acttcaggga 2700
gaaagagtta caagtacatg caatgagtga actgactgtg gctacaatct tgaagatata 2760
cggaagagac gtattattaa tgcttgacat atatcatctt gcctttcttg gtctagactg 2820
acttctaatg actaactcaa agtcaaggca actgagtaat gtcagctcag caaagtgcag 2880
caaacccatc tcccacaggc ctccaaaccc tggctgttca cagaaccaca aagggcagat 2940
gctgcacaga aaactagaga aggggtcata ggttcatggt tttgtttgag atttgttgct 3000
actgtttttc tgttttgaat tttcttcttt gttctgtttt tactttattt agggggacta 3060
ggtgtttctg atattttagt tttcttgttt gttttgtttt gtgttgtctg tgaatggggt 3120
tttaactgtg gatgaatgga ccttatctgt tggcttaaag gactggtaag atcagaccat 3180
cttattcttc aggtgaatgt tttactttcc aaagtgctct cctctgcacc agcagtaata 3240
aatacaatgc cataatccct taggtttgcc tagtgctttt gcaattttca aagcacttcc 3300
ataagcattc cttccacctc cttgataggc atttatggaa agcctgctac atgtcaatca 3360
tactgttagg cacaggggac ctaaagacac ataaaaggat ggcattctgc ctcataaatt 3420
gcaaaaccta atgaaagtga ctgcttggta aacaaattat tattatatta taaaatgcta 3480
taaaagagcc atattgaaag tgccctgttg gagacagggc aaatgccaca aaaatgatgt 3540
aaatttacat ggaggaaaag tagaatctgc ctggtttgta ggcagcagaa gacatttttc 3600
atcagtgggc aggtgttctt taccttttgt agaaatggga gtcaagtctc aaataggagg 3660
ctccacaaaa tctcatgcca ggtctctgat accttattca cagaagttct ttgaagtatt 3720
tattgttatt ttctttgact tatgggaaaa ctgggacaca ggaagacagg taaattaccc 3780
aacctcacac gttaagtcag aactgggagc cataattttg tatccctggt ataaatagac 3840
aatctcttga agaaatgaag agatgaccat agaaaaacat cgagatatct ccagctctaa 3900
aatcctttgt ttcaatgttg tttggcatat gttatctttg gaatttagtg tctgagcctc 3960
tgtctgttac tgtagtattt aaaatgcatg tattataatc atataatcat aactgctgtt 4020
aattcttgat tatataccta gggacaatgt gtaatgtaag attactaatt ggttctgccc 4080
aatctccttt cagattttat taggaaaaaa aaataaacct cctgatcgga gacaatgtat 4140
taatcagaag tgtaaactgc cagttctata tagcatgaaa tgaaaagaca gctaatttgg 4200
tccaacaaac atgactgggt ctagggcacc caggctgatt cagctgattt cctaccagcc 4260
tttgcctctt ccttcaatgt ggtttccatg ggaatttgct tcagaaaagc caagtatggg 4320
ctgttcagag gtgcacacct gcattttctt agctcttcta gaggggctaa gagacttggt 4380
acgggccagg aagaatatgt ggcagagctc ctggaaatga tgcagattag gtggcatttt 4440
tgtcagctct gtggtttatt gttgggacta ttctttaaaa tatccattgt tcactacagt 4500
gaagatctct gatttaaccg tgtactatcc acatgcatta caaacatttc gcagagctgc 4560
ttagtatata agcgtacaat gtatgtaata accatctcat atttaattaa atggtataga 4620
agaacaaaaa aaaaaaaaaa aaa 4643
<210> 227
<211> 1642
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1642)
<223> IL-8 mRNA
<400> 227
acaaactttc agagacagca gagcacacaa gcttctagga caagagccag gaagaaacca 60
ccggaaggaa ccatctcact gtgtgtaaac atgacttcca agctggccgt ggctctcttg 120
gcagccttcc tgatttctgc agctctgtgt gaaggtgcag ttttgccaag gagtgctaaa 180
gaacttagat gtcagtgcat aaagacatac tccaaacctt tccaccccaa atttatcaaa 240
gaactgagag tgattgagag tggaccacac tgcgccaaca cagaaattat tgtaaagctt 300
tctgatggaa gagagctctg tctggacccc aaggaaaact gggtgcagag ggttgtggag 360
aagtttttga agagggctga gaattcataa aaaaattcat tctctgtggt atccaagaat 420
cagtgaagat gccagtgaaa cttcaagcaa atctacttca acacttcatg tattgtgtgg 480
gtctgttgta gggttgccag atgcaataca agattcctgg ttaaatttga atttcagtaa 540
acaatgaata gtttttcatt gtaccatgaa atatccagaa catacttata tgtaaagtat 600
tatttatttg aatctacaaa aaacaacaaa taatttttaa atataaggat tttcctagat 660
attgcacggg agaatataca aatagcaaaa ttgaggccaa gggccaagag aatatccgaa 720
ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca tcacataaaa 780
atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct ggattttttt 840
ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg ttccactgtg 900
ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt acctcacagt 960
gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata aattattttc 1020
aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca aatatttgtg 1080
caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag atgttatagt 1140
aaatttattt tattttagat attaaatgat gttttattag ataaatttca atcagggttt 1200
ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag ataaacaaca 1260
aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga actaacaatc 1320
ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg tgttgaatta 1380
cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata ttagtaattt 1440
cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt atttaaatga 1500
ctgcattttt aaatacaagg ctttatattt ttaactttaa gatgttttta tgtgctctcc 1560
aaattttttt tactgtttct gattgtatgg aaatataaaa gtaaatatga aacatttaaa 1620
atataatttg ttgtcaaagt aa 1642
<210> 228
<211> 4811
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4811)
<223> ITGA1 mRNA
<400> 228
ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc 60
tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctgttgttct 120
acgctgctgc gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt 180
ggaagacatg tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatgggtgct 240
tattggttct ccgttagttg gccaacccaa aaacagaact ggagatgtct ataagtgtcc 300
agttgggaga ggtgaatcat taccttgtgt aaagttggat ctaccagtta atacatcaat 360
tcccaatgtc acagaagtaa aggagaacat gacatttgga tcaactttag tcaccaaccc 420
aaatggagga tttctggctt gtgggccctt atatgcctat agatgtggac atttgcatta 480
cacaactgga atctgttctg acgtcagccc cacatttcaa gtcgtgaatt ccattgcccc 540
tgtacaagaa tgcagcactc aactggacat agtcatagtg ctggatggtt ccaacagtat 600
ttacccatgg gacagtgtta cagctttttt aaatgacctt cttgaaagaa tggatattgg 660
tcctaaacag acacaggttg gaattgtaca gtatggagaa aacgtgaccc atgagttcaa 720
cctcaataag tattcttcca ccgaagaggt acttgttgca gcaaagaaaa tagtccagag 780
aggtggccgc cagactatga cagctcttgg aatagacaca gcaagaaagg aggcattcac 840
ggaagcccgg ggtgcccgaa gaggagttaa aaaagtcatg gttattgtga cagatggaga 900
gtctcatgac aatcatcgac tgaagaaggt catccaagac tgtgaagatg aaaacattca 960
acggttttcc atagctattc ttggcagcta taaccgagga aatttaagca ctgaaaaatt 1020
tgtggaggaa ataaaatcaa ttgcaagtga acccactgaa aagcatttct tcaatgtctc 1080
tgatgaattg gctctagtca ccattgttaa aactctggga gaaagaatat ttgccctgga 1140
agccacagct gaccagtcag cagcttcatt tgaaatggaa atgtctcaga ctggcttcag 1200
tgctcattat tcacaggact gggtcatgct tggagcagta ggagcctatg attggaatgg 1260
aacagttgtc atgcagaagg ctagtcaaat cataatccct cgaaacacaa cctttaatgt 1320
tgagtctacc aaaaagaatg aaccgcttgc ttcttattta ggttacactg taaactctgc 1380
tactgcttct tctggagatg tgctctatat tgctggacag cctcggtaca atcatacagg 1440
ccaggtcatt atctacagga tggaagatgg aaacatcaaa attctccaga cgctcagtgg 1500
agaacagatt ggttcctact ttggcagtat tttaacaaca actgacattg acaaggattc 1560
taatactgac attcttctag tcggagcccc tatgtacatg ggaacagaga aggaggagca 1620
aggaaaagtg tatgtgtatg ctctcaatca gacaaggttt gaatatcaaa tgagcctgga 1680
acctattaag cagacgtgct gttcatctcg gcagcacaat tcatgcacaa cagaaaacaa 1740
aaatgagcca tgcggggctc gttttggaac tgcaattgct gctgtaaaag acctcaatct 1800
tgatggattt aatgacatcg tgataggagc tccgctggaa gatgatcacg ggggagctgt 1860
gtacatttat catggaagtg gcaagactat aaggaaagag tatgcacaac gtattccatc 1920
aggtggggat ggtaagacac tgaaattttt tggccagtct atccacggag aaatggattt 1980
aaatggtgac ggtctgacag atgtgactat tgggggcctt ggtggtgctg ccctcttctg 2040
gtcccgagat gtggccgtag ttaaagtgac catgaatttt gagccaaata aagtgaatat 2100
tcaaaagaaa aactgccata tggagggaaa ggaaacagta tgcataaatg ctacagtgtg 2160
ttttgatgtg aaattaaagt ctaaagaaga cacgatttat gaagctgatt tgcagtaccg 2220
tgtcacccta gattcactaa gacaaatatc acgaagtttt ttctctggaa ctcaagagag 2280
aaaggttcaa aggaacatca cagttcgaaa atcagaatgc actaagcact ccttctacat 2340
gttggacaag catgactttc aggactctgt gagaataacg ttggacttta atcttaccga 2400
tccagaaaat gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc 2460
ctttgccaaa gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc 2520
caccactgaa aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct 2580
cacagtcaaa aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc 2640
aaatctagtt ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa 2700
tatcacatgt aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat 2760
attgtttcag tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac 2820
aagtgacagc gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc 2880
ggtaaaatat gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat 2940
tgctgccaat gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat 3000
taatatcttc tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc 3060
aatttcattc cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc 3120
atcttctgag aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc 3180
tggaaagaaa atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa 3240
tacatgtaaa tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa 3300
tgtttcgctt atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct 3360
tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca 3420
aaaaagagag cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg 3480
ggtcatcctg ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact 3540
gtggaagatt ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt 3600
atgaaagaaa ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg 3660
acaagaaatg tataattcat gacatagtca tgtaactatg taatccatca gggattcatt 3720
acttggaaaa tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata 3780
aaatgacaaa aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag 3840
tgtttttaaa aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta 3900
aggaatatat aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat 3960
taagcttttc cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt 4020
aaatgccaag aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt 4080
ttcccttggt agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt 4140
agcatctttg tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga 4200
aagtactgca attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa 4260
aaacaagtat attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt 4320
gagctctaaa tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca 4380
tcacagtgat ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg 4440
aaatacgaca gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt 4500
ttgaatgcta agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac 4560
agggttcatt caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta 4620
tttaatttcc aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac 4680
attttaccaa gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca 4740
gaaatgtatt ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcaaaaa 4800
aaaaaaaaaa a 4811
<210> 229
<211> 7843
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(7843)
<223> ITGA2 mRNA
<400> 229
agagaagccc tctggacagc ttctagagtg tgcaggttct cgtatccctc ggccaagggt 60
atcctctgca aacctctgca aacccagcgc aactacggtc ccccggtcag acccaggatg 120
gggccagaac ggacaggggc cgcgccgctg ccgctgctgc tggtgttagc gctcagtcaa 180
ggcattttaa attgttgttt ggcctacaat gttggtctcc cagaagcaaa aatattttcc 240
ggtccttcaa gtgaacagtt tggctatgca gtgcagcagt ttataaatcc aaaaggcaac 300
tggttactgg ttggttcacc ctggagtggc tttcctgaga accgaatggg agatgtgtat 360
aaatgtcctg ttgacctatc cactgccaca tgtgaaaaac taaatttgca aacttcaaca 420
agcattccaa atgttactga gatgaaaacc aacatgagcc tcggcttgat cctcaccagg 480
aacatgggaa ctggaggttt tctcacatgt ggtcctctgt gggcacagca atgtgggaat 540
cagtattaca caacgggtgt gtgttctgac atcagtcctg attttcagct ctcagccagc 600
ttctcacctg caactcagcc ctgcccttcc ctcatagatg ttgtggttgt gtgtgatgaa 660
tcaaatagta tttatccttg ggatgcagta aagaattttt tggaaaaatt tgtacaaggc 720
ctggatatag gccccacaaa gacacaggtg gggttaattc agtatgccaa taatccaaga 780
gttgtgttta acttgaacac atataaaacc aaagaagaaa tgattgtagc aacatcccag 840
acatcccaat atggtgggga cctcacaaac acattcggag caattcaata tgcaagaaaa 900
tatgcttatt cagcagcttc tggtgggcga cgaagtgcta cgaaagtaat ggtagttgta 960
actgacggtg aatcacatga tggttcaatg ttgaaagctg tgattgatca atgcaaccat 1020
gacaatatac tgaggtttgg catagcagtt cttgggtact taaacagaaa cgcccttgat 1080
actaaaaatt taataaaaga aataaaagca atcgctagta ttccaacaga aagatacttt 1140
ttcaatgtgt ctgatgaagc agctctacta gaaaaggctg ggacattagg agaacaaatt 1200
ttcagcattg aaggtactgt tcaaggagga gacaactttc agatggaaat gtcacaagtg 1260
ggattcagtg cagattactc ttctcaaaat gatattctga tgctgggtgc agtgggagct 1320
tttggctgga gtgggaccat tgtccagaag acatctcatg gccatttgat ctttcctaaa 1380
caagcctttg accaaattct gcaggacaga aatcacagtt catatttagg ttactctgtg 1440
gctgcaattt ctactggaga aagcactcac tttgttgctg gtgctcctcg ggcaaattat 1500
accggccaga tagtgctata tagtgtgaat gagaatggca atatcacggt tattcaggct 1560
caccgaggtg accagattgg ctcctatttt ggtagtgtgc tgtgttcagt tgatgtggat 1620
aaagacacca ttacagacgt gctcttggta ggtgcaccaa tgtacatgag tgacctaaag 1680
aaagaggaag gaagagtcta cctgtttact atcaaagagg gcattttggg tcagcaccaa 1740
tttcttgaag gccccgaggg cattgaaaac actcgatttg gttcagcaat tgcagctctt 1800
tcagacatca acatggatgg ctttaatgat gtgattgttg gttcaccact agaaaatcag 1860
aattctggag ctgtatacat ttacaatggt catcagggca ctatccgcac aaagtattcc 1920
cagaaaatct tgggatccga tggagccttt aggagccatc tccagtactt tgggaggtcc 1980
ttggatggct atggagattt aaatggggat tccatcaccg atgtgtctat tggtgccttt 2040
ggacaagtgg ttcaactctg gtcacaaagt attgctgatg tagctataga agcttcattc 2100
acaccagaaa aaatcacttt ggtcaacaag aatgctcaga taattctcaa actctgcttc 2160
agtgcaaagt tcagacctac taagcaaaac aatcaagtgg ccattgtata taacatcaca 2220
cttgatgcag atggattttc atccagagta acctccaggg ggttatttaa agaaaacaat 2280
gaaaggtgcc tgcagaagaa tatggtagta aatcaagcac agagttgccc cgagcacatc 2340
atttatatac aggagccctc tgatgttgtc aactctttgg atttgcgtgt ggacatcagt 2400
ctggaaaacc ctggcactag ccctgccctt gaagcctatt ctgagactgc caaggtcttc 2460
agtattcctt tccacaaaga ctgtggtgag gacggacttt gcatttctga tctagtccta 2520
gatgtccgac aaataccagc tgctcaagaa caacccttta ttgtcagcaa ccaaaacaaa 2580
aggttaacat tttcagtaac gctgaaaaat aaaagggaaa gtgcatacaa cactggaatt 2640
gttgttgatt tttcagaaaa cttgtttttt gcatcattct ccctgccggt tgatgggaca 2700
gaagtaacat gccaggtggc tgcatctcag aagtctgttg cctgcgatgt aggctaccct 2760
gctttaaaga gagaacaaca ggtgactttt actattaact ttgacttcaa tcttcaaaac 2820
cttcagaatc aggcgtctct cagtttccaa gccttaagtg aaagccaaga agaaaacaag 2880
gctgataatt tggtcaacct caaaattcct ctcctgtatg atgctgaaat tcacttaaca 2940
agatctacca acataaattt ttatgaaatc tcttcggatg ggaatgttcc ttcaatcgtg 3000
cacagttttg aagatgttgg tccaaaattc atcttctccc tgaaggtaac aacaggaagt 3060
gttccagtaa gcatggcaac tgtaatcatc cacatccctc agtataccaa agaaaagaac 3120
ccactgatgt acctaactgg ggtgcaaaca gacaaggctg gtgacatcag ttgtaatgca 3180
gatatcaatc cactgaaaat aggacaaaca tcttcttctg tatctttcaa aagtgaaaat 3240
ttcaggcaca ccaaagaatt gaactgcaga actgcttcct gtagtaatgt tacctgctgg 3300
ttgaaagacg ttcacatgaa aggagaatac tttgttaatg tgactaccag aatttggaac 3360
gggactttcg catcatcaac gttccagaca gtacagctaa cggcagctgc agaaatcaac 3420
acctataacc ctgagatata tgtgattgaa gataacactg ttacgattcc cctgatgata 3480
atgaaacctg atgagaaagc cgaagtacca acaggagtta taataggaag tataattgct 3540
ggaatccttt tgctgttagc tctggttgca attttatgga agctcggctt cttcaaaaga 3600
aaatatgaaa agatgaccaa aaatccagat gagattgatg agaccacaga gctcagtagc 3660
tgaaccagca gacctacctg cagtgggaac cggcagcatc ccagccaggg tttgctgttt 3720
gcgtgaatgg atttcttttt aaatcccata ttttttttat catgtcgtag gtaaactaac 3780
ctggtatttt aagagaaaac tgcaggtcag tttggaatga agaaattgtg gggggtgggg 3840
gaggtgcggg gggcaggtag ggaaataata gggaaaatac ctattttata tgatggggga 3900
aaaaaagtaa tctttaaact ggctggccca gagtttacat tctaatttgc attgtgtcag 3960
aaacatgaaa tgcttccaag catgacaact tttaaagaaa aatatgatac tctcagattt 4020
taagggggaa aactgttctc tttaaaatat ttgtctttaa acagcaacta cagaagtgga 4080
agtgcttgat atgtaagtac ttccacttgt gtatatttta atgaatattg atgttaacaa 4140
gaggggaaaa caaaacacag gttttttcaa tttatgctgc tcatccaaag ttgccacaga 4200
tgatacttcc aagtgataat tttatttata aactaggtaa aatttgttgt tggttccttt 4260
tagaccacgg ctgccccttc cacaccccat cttgctctaa tgatcaaaac atgcttgaat 4320
aactgagctt agagtatacc tcctatatgt ccatttaagt taggagaggg ggcgatatag 4380
agaataaggc acaaaatttt gtttaaaact cagaatataa catgtaaaat cccatctgct 4440
agaagcccat cctgtgccag aggaaggaaa aggaggaaat ttcctttctc ttttaggagg 4500
cacaacagtt ctcttctagg atttgtttgg ctgactggca gtaacctagt gaatttctga 4560
aagatgagta atttctttgg caaccttcct cctcccttac tgaaccactc tcccacctcc 4620
tggtggtacc attattatag aagccctcta cagcctgact ttctctccag cggtccaaag 4680
ttatcccctc ctttacccct catccaaagt tcccactcct tcaggacagc tgctgtgcat 4740
tagatattag gggggaaagt catctgttta atttacacac ttgcatgaat tactgtatat 4800
aaactcctta acttcaggga gctattttca tttagtgcta aacaagtaag aaaaataagc 4860
tcgagtgaat ttctaaatgt tggaatgtta tgggatgtaa acaatgtaaa gtaagacatc 4920
tcaggatttc accagaagtt acagatgagg cactggaagc caccaaatta gcaggtgcac 4980
cttctgtggc tgtcttgttt ctgaagtact taaacttcca caagagtgaa tttgacctag 5040
gcaagtttgt tcaaaaggta gatcctgaga tgatttggtc agattgggat aaggcccagc 5100
aatctgcatt ttaacaagca ccccagtcac taggatgcag atggaccaca ctttgagaaa 5160
caccacccat ttctactttt tgcaccttat tttctctgtt cctgagcccc cacattctct 5220
aggagaaact tagaggaaaa gggcacagac actacatatc taaagctttg gacaagtcct 5280
tgacctctat aaacttcaga gtcctcatta taaaatggga agactgagct ggagttcagc 5340
agtgatgctt ttagttttaa aagtctatga tctggacttc ctataataca aatacacaat 5400
cctccaagaa tttgacttgg aaaaaaatgt caaaggaaaa caggttatct gcccatgtgc 5460
atatggacaa ccttgactac cctggcctgg cccgtggtgg cagtccaggg ctatctgtac 5520
tgtttacaga attactttgt agttgacaac acaaaacaaa caaaaaaggc ataaaatgcc 5580
agcggtttat agaaaaaaca gcatggtatt ctccagttag gtatgccaga gtccaattct 5640
tttaacagct gtgagaattt gctgcttcat tccaacaaaa ttttatttaa aaaaaaaaaa 5700
aaaagactgg agaaactagt cattagcttg ataaagaata tttaacagct agtggtgctg 5760
gtgtgtacct gaagctccag ctacttgaga gactgagaca ggaagatcgc ttgagcccag 5820
gagttcaagt ccagcctaag caacatagca agaccctgtc tcaaaaaaat gactatttaa 5880
aaagacaatg tggccaggca cggtggctca cacctgtaat cccaacactt tgggaggctg 5940
aggccggtgg atcacgaggt caggagtttg agactagcct ggccaacatg gtgaaacccc 6000
atctctaata atataaaaat tagctgggcg tagtagcagg tgcctgtaat cccagttact 6060
cgggaagctg aggcaggaga atcacttgaa cccgggaggc agaggtttca gtgagccgag 6120
atcgcgccac tgcactccag cctgggtgac agggcaagac tctgtctcaa acaaacaaac 6180
aaaaaaaaag ttagtactgt atatgtaaat actagctttt caatgtgcta tacaaacaat 6240
tatagcacat ccttcctttt actctgtctc acctccttta ggtgagtact tccttaaata 6300
agtgctaaac atacatatac ggaacttgaa agctttggtt agccttgcct taggtaatca 6360
gcctagttta cactgtttcc agggagtagt tgaattacta taaaccatta gccacttgtc 6420
tctgcaccat ttatcacacc aggacagggt ctctcaacct gggcgctact gtcatttggg 6480
gccaggtgat tcttccttgc aggggctgtc ctgtaccttg taggacagca gccctgtcct 6540
agaaggtatg tttagcagca ttcctggcct ctagctaccc gatgccagag catgctcccc 6600
ccgcagtcat gacaatcaaa aaatgtctcc agacattgtc aaatgcctcc tggggggcag 6660
tatttctcaa gcacttttaa gcaaaggtaa gtattcatac aagaaattta gggggaaaaa 6720
acattgttta aataaaagct atgtgttcct attcaacaat atttttgctt taaaagtaag 6780
tagagggcat aaaagatgtc atattcaaat ttccatttca taaatggtgt acagacaagg 6840
tctatagaat gtggtaaaaa cttgactgca acacaaggct tataaaatag taagatagta 6900
aaatagctta tgaagaaact acagagattt aaaattgtgc atgactcatt tcagcagcaa 6960
aataagaact cctaactgaa cagaaatttt tctacctagc aatgttattc ttgtaaaata 7020
gttacctatt aaaactgtga agagtaaaac taaagccaat ttattatagt cacacaagtg 7080
attatactaa aaattattat aaaggttata attttataat gtatttacct gtcctgatat 7140
atagctataa cccaatatat gaaaatctca aaaattaaga catcatcata cagaaggcag 7200
gattccttaa actgagatcc ctgatccatc tttaatattt caatttgcac acataaaaca 7260
atgccctttt gtgtacattc aggcataccc attttaatca atttgaaagg ttaatttaaa 7320
cctctagagg tgaatgagaa acatggggga aaagtatgaa ataggtgaaa atcttaacta 7380
tttctttgaa ctctaaagac tgaaactgta gccattatgt aaataaagtt tcatatgtac 7440
ctgtttattt tggcagatta agtcaaaata tgaatgtata tattgcataa ctatgttaga 7500
attgtatata ttttaaagaa attgtcttgg atattttcct ttatacataa tagataagtc 7560
ttttttcaaa tgtggtgttt gatgtttttg attaaatgtg ttttgcctct ttccacaaaa 7620
actgtaaaaa taaatgcatg tttgtacaaa aagttgcaga attcatttga tttatgagaa 7680
acaaaaatta aattgtagtc aacagttagt agtttttctc atatccaagt ataacaaaca 7740
gaaaagtttc attattgtaa cccacttttt tcataccaca ttattgaata ttgttacaat 7800
tgttttgaaa ataaagccat tttctttggg cttttataag tta 7843
<210> 230
<211> 4889
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4889)
<223> ITGA3 mRNA
<400> 230
agatccgccg cgaagccggg atcgaaggcg acagcgcggc caagggggcg cggccgggac 60
aagctggggg ccggttgccc ggggcaggga cggcggcgac ccggccgctg gggaggcagg 120
aagatagacc cacggatctt aggaagggat ccgagagcgc agctgtgaaa ctggctgggg 180
ctgggggcac gaaaccgatc agcgctacgg agcgcagcgg ccggcgggtt ccagtgtcct 240
ccggcggcgc ggggagcagg tgaacaggtc ctcacgccca gctccgcgcc ctcacgcgct 300
ctcgccggga ccccgcttcc gctggcagcc atgggccccg gccccagccg cgcgccccgc 360
gccccacgcc tgatgctctg tgcgctcgcc ttgatggtgg cggccggcgg ctgcgtcgtc 420
tccgccttca acctggatac ccgattcctg gtagtgaagg aggccgggaa cccgggcagc 480
ctcttcggct actcggtcgc cctccatcgg cagacagagc ggcagcagcg ctacctgctc 540
ctggctggtg ccccccggga gctcgctgtg cccgatggct acaccaaccg gactggtgct 600
gtgtacctgt gcccactcac tgcccacaag gatgactgtg agcggatgaa catcacagtg 660
aaaaatgacc ctggccatca cattattgag gacatgtggc ttggagtgac tgtggccagc 720
cagggccctg caggcagagt tctggtctgt gcccaccgct acacccaggt gctgtggtca 780
gggtcagaag accagcggcg catggtgggc aagtgctacg tgcgaggcaa tgacctagag 840
ctggactcca gtgatgactg gcagacctac cacaacgaga tgtgcaatag caacacagac 900
tacctggaga cgggcatgtg ccagctgggc accagcggtg gcttcaccca gaacactgtg 960
tacttcggcg cccccggtgc ctacaactgg aaaggaaaca gctacatgat tcagcgcaag 1020
gagtgggact tatctgagta tagttacaag gacccagagg accaaggaaa cctctatatt 1080
gggtacacga tgcaggtagg cagcttcatc ctgcacccca aaaacatcac cattgtgaca 1140
ggtgccccac ggcaccgaca tatgggcgcg gtgttcttgc tgagccagga ggcaggcgga 1200
gacctgcgga ggaggcaggt gctggagggc tcgcaggtgg gcgcctattt tggcagcgcc 1260
attgccctgg cagacctgaa caatgatggg tggcaggacc tcctggtggg cgccccctac 1320
tacttcgaga ggaaagagga agtagggggt gccatctatg tcttcatgaa ccaggcggga 1380
acctccttcc ctgctcaccc ctcactcctt cttcatggcc ccagtggctc tgcctttggt 1440
ttatctgtgg ccagcattgg tgacatcaac caggatggat ttcaggatat tgctgtggga 1500
gctccgtttg aaggcttggg caaagtgtac atctatcaca gtagctctaa ggggctcctt 1560
agacagcccc agcaggtaat ccatggagag aagctgggac tgcctgggtt ggccaccttc 1620
ggctattccc tcagtgggca gatggatgtg gatgagaact tctacccaga ccttctagtg 1680
ggaagcctgt cagaccacat tgtgctgctg cgggcccggc ccgtcatcaa catcgtccac 1740
aagaccttgg tgcccaggcc agctgtgctg gaccctgcac tttgcacggc cacctcttgt 1800
gtgcaagtgg agctgtgctt tgcttacaac cagagtgccg ggaaccccaa ctacaggcga 1860
aacatcaccc tggcctacac tctggaggct gacagggacc gccggccgcc ccggctccgc 1920
tttgccggca gtgagtccgc tgtcttccac ggcttcttct ccatgcccga gatgcgctgc 1980
cagaagctgg agctgctcct gatggacaac ctccgtgaca aactccgccc catcatcatc 2040
tccatgaact actctttacc tttgcggatg cccgatcgcc cccggctggg gctgcggtcc 2100
ctggacgcct acccgatcct caaccaggca caggctctgg agaaccacac tgaggtccag 2160
ttccagaagg agtgcgggcc tgacaacaag tgtgagagca acttgcagat gcgggcagcc 2220
ttcgtgtcag agcagcagca gaagctgagc aggctccagt acagcagaga cgtccggaaa 2280
ttgctcctga gcatcaacgt gacgaacacc cggacctcgg agcgctccgg ggaggacgcc 2340
cacgaggcgc tgctcaccct ggtggtgcct cccgccctgc tgctgtcctc agtgcgcccc 2400
cccggggcct gccaagctaa tgagaccatc ttttgcgagc tggggaaccc cttcaaacgg 2460
aaccagagga tggagctgct catcgccttt gaggtcatcg gggtgaccct gcacacaagg 2520
gaccttcagg tgcagctgca gctctccacg tcgagtcacc aggacaacct gtggcccatg 2580
atcctcactc tgctggtgga ctatacactc cagacctcgc ttagcatggt aaatcaccgg 2640
ctacaaagct tctttggggg gacagtgatg ggtgagtctg gcatgaaaac tgtggaggat 2700
gtaggaagcc ccctcaagta tgaattccag gtgggcccaa tgggggaggg gctggtgggc 2760
ctggggaccc tggtcctagg tctggagtgg ccctacgaag tcagcaatgg caagtggctg 2820
ctgtatccca cggagatcac cgtccatggc aatgggtcct ggccctgccg accacctgga 2880
gaccttatca accctctcaa cctcactctt tctgaccctg gggacaggcc atcatcccca 2940
cagcgcaggc ggcgacagct ggatccaggg ggaggccagg gccccccacc tgtcactctg 3000
gctgctgcca aaaaagccaa gtctgagact gtgctgacct gtgccacagg gcgtgcccac 3060
tgtgtgtggc tagagtgccc catccctgat gcccccgttg tcaccaacgt gactgtgaag 3120
gcacgagtgt ggaacagcac cttcatcgag gattacagag actttgaccg agtccgggta 3180
aatggctggg ctaccctatt cctccgaacc agcatcccca ccatcaacat ggagaacaag 3240
accacgtggt tctctgtgga cattgactcg gagctggtgg aggagctgcc ggccgaaatc 3300
gagctgtggc tggtgctggt ggccgtgggt gcagggctgc tgctgctggg gctgatcatc 3360
ctcctgctgt ggaagtgcgg cttcttcaag cgagcccgca ctcgcgccct gtatgaagct 3420
aagaggcaga aggcggagat gaagagccag ccgtcagaga cagagaggct gaccgacgac 3480
tactgagggg gcagcccccc gcccccggcc cacctggtgt gacttcttta agcggacccg 3540
ctattatcag atcatgccca agtaccacgc agtgcggatc cgggaggagg agcgctaccc 3600
acctccaggg agcaccctgc ccaccaagaa gcactgggtg accagctggc agactcggga 3660
ccaatactac tgacgtcctc cctgatccca ccccctcctc ccccagtgtc ccctttcttc 3720
ctatttatca taagttatgc ctctgacagt ccacaggggc caccaccttt ggctggtagc 3780
agcaggctca ggcacataca cctcgtcaag agcatgcaca tgctgtctgg ccctggggat 3840
cttcccacag gagggccagc gctgtggacc ttacaacgcc gagtgcactg cattcctgtg 3900
ccctagatgc acgtggggcc cactgctcgt ggactgtgct ggtgcatcac ggatggtgca 3960
tgggctcgcc gtgtctcagc ctctgccagc gccaaaacaa gccaaagagc ctcccaccag 4020
agccgggagg aaaaggcccc tgcaatgtgg tgacacctcc ccctttcaca ctggatccat 4080
cttgagccac agtcactgga ttgactttgc tgtcaaaact actgacaggg agcagccccc 4140
gggccgctgg ctggtgggcc cccaatgaca cccatgccag agaggtgggg atcctgccta 4200
aggttgtcta cgggggcact tggaggacct ggcgtgctca gacccaacag caaaggaact 4260
agaaagaagg acccagaacg gcttgctttc ctgcatctct gtgaagcctc tctccttggc 4320
cacagactga actcgcaggg aatgcagcag gaaggaacaa agacaggcaa acggcaacgt 4380
agcctgggct cactgtgctg gggcacggcg ggatcctcca cagagaggag gggaccaatt 4440
ctggacagac agatgttggg aggatacaga ggagatgcca cttctcactc accactacca 4500
gccagcctca gaaggcccca gagagaccct gcaagaccac ggagggagcg acacttgaat 4560
gtagaatagg cagggggccc tgccccaccc catccagcca gaccccacgc tgaccatgcg 4620
tcaggggcct agaggtggag ttcttagcta tccttggctt tcagagccag cctggctctg 4680
ccccctcccc catgggctgt gtcctaaggc ccatttgaga agctgaggct agttccagaa 4740
aacctctcct gacccctgcc tgttggcagg cccactcccc agccccagcc ccttccatgg 4800
tactgtagca ggggaattcc ctccccctcc ttgtgccttc tttgtatata ggcttctcac 4860
ggcgaccaat aaacagctcc cagtttgta 4889
<210> 231
<211> 6781
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6781)
<223> ITGA4 mRNA
<400> 231
gaagcagcgc gagcacccga agctcccggc tggcggcaga aaccgggagt ggggccgggc 60
gagtgcgcgg catcccaggc cggcccgaac gctccgcccg cggtgggccg acttcccctc 120
ctcttccctc tctccttcct ttagcccgct ggcgccggac acgctgcgcc tcatctcttg 180
gggcgttctt ccccgttggc caaccgtcgc atcccgtgca actttggggt agtggccgtt 240
tagtgttgaa tgttccccac cgagagcgca tggcttggga agcgaggcgc gaacccggcc 300
cccgaagggc cgccgtccgg gagacggtga tgctgttgct gtgcctgggg gtcccgaccg 360
gccgccccta caacgtggac actgagagcg cgctgcttta ccagggcccc cacaacacgc 420
tgttcggcta ctcggtcgtg ctgcacagcc acggggcgaa ccgatggctc ctagtgggtg 480
cgcccactgc caactggctc gccaacgctt cagtgatcaa tcccggggcg atttacagat 540
gcaggatcgg aaagaatccc ggccagacgt gcgaacagct ccagctgggt agccctaatg 600
gagaaccttg tggaaagact tgtttggaag agagagacaa tcagtggttg ggggtcacac 660
tttccagaca gccaggagaa aatggatcca tcgtgacttg tgggcataga tggaaaaata 720
tattttacat aaagaatgaa aataagctcc ccactggtgg ttgctatgga gtgccccctg 780
atttacgaac agaactgagt aaaagaatag ctccgtgtta tcaagattat gtgaaaaaat 840
ttggagaaaa ttttgcatca tgtcaagctg gaatatccag tttttacaca aaggatttaa 900
ttgtgatggg ggccccagga tcatcttact ggactggctc tctttttgtc tacaatataa 960
ctacaaataa atacaaggct tttttagaca aacaaaatca agtaaaattt ggaagttatt 1020
taggatattc agtcggagct ggtcattttc ggagccagca tactaccgaa gtagtcggag 1080
gagctcctca acatgagcag attggtaagg catatatatt cagcattgat gaaaaagaac 1140
taaatatctt acatgaaatg aaaggtaaaa agcttggatc gtactttgga gcttctgtct 1200
gtgctgtgga cctcaatgca gatggcttct cagatctgct cgtgggagca cccatgcaga 1260
gcaccatcag agaggaagga agagtgtttg tgtacatcaa ctctggctcg ggagcagtaa 1320
tgaatgcaat ggaaacaaac ctcgttggaa gtgacaaata tgctgcaaga tttggggaat 1380
ctatagttaa tcttggcgac attgacaatg atggctttga agatgttgct atcggagctc 1440
cacaagaaga tgacttgcaa ggtgctattt atatttacaa tggccgtgca gatgggatct 1500
cgtcaacctt ctcacagaga attgaaggac ttcagatcag caaatcgtta agtatgtttg 1560
gacagtctat atcaggacaa attgatgcag ataataatgg ctatgtagat gtagcagttg 1620
gtgcttttcg gtctgattct gctgtcttgc taaggacaag acctgtagta attgttgacg 1680
cttctttaag ccaccctgag tcagtaaata gaacgaaatt tgactgtgtt gaaaatggat 1740
ggccttctgt gtgcatagat ctaacacttt gtttctcata taagggcaag gaagttccag 1800
gttacattgt tttgttttat aacatgagtt tggatgtgaa cagaaaggca gagtctccac 1860
caagattcta tttctcttct aatggaactt ctgacgtgat tacaggaagc atacaggtgt 1920
ccagcagaga agctaactgt agaacacatc aagcatttat gcggaaagat gtgcgggaca 1980
tcctcacccc aattcagatt gaagctgctt accaccttgg tcctcatgtc atcagtaaac 2040
gaagtacaga ggaattccca ccacttcagc caattcttca gcagaagaaa gaaaaagaca 2100
taatgaaaaa aacaataaac tttgcaaggt tttgtgccca tgaaaattgt tctgctgatt 2160
tacaggtttc tgcaaagatt gggtttttga agccccatga aaataaaaca tatcttgctg 2220
ttgggagtat gaagacattg atgttgaatg tgtccttgtt taatgctgga gatgatgcat 2280
atgaaacgac tctacatgtc aaactacccg tgggtcttta tttcattaag attttagagc 2340
tggaagagaa gcaaataaac tgtgaagtca cagataactc tggcgtggta caacttgact 2400
gcagtattgg ctatatatat gtagatcatc tctcaaggat agatattagc tttctcctgg 2460
atgtgagctc actcagcaga gcggaagagg acctcagtat cacagtgcat gctacctgtg 2520
aaaatgaaga ggaaatggac aatctaaagc acagcagagt gactgtagca atacctttaa 2580
aatatgaggt taagctgact gttcatgggt ttgtaaaccc aacttcattt gtgtatggat 2640
caaatgatga aaatgagcct gaaacgtgca tggtggagaa aatgaactta actttccatg 2700
ttatcaacac tggcaatagt atggctccca atgttagtgt ggaaataatg gtaccaaatt 2760
cttttagccc ccaaactgat aagctgttca acattttgga tgtccagact actactggag 2820
aatgccactt tgaaaattat caaagagtgt gtgcattaga gcagcaaaag agtgcaatgc 2880
agaccttgaa aggcatagtc cggttcttgt ccaagactga taagaggcta ttgtactgca 2940
taaaagctga tccacattgt ttaaatttct tgtgtaattt tgggaaaatg gaaagtggaa 3000
aagaagccag tgttcatatc caactggaag gccggccatc cattttagaa atggatgaga 3060
cttcagcact caagtttgaa ataagagcaa caggttttcc agagccaaat ccaagagtaa 3120
ttgaactaaa caaggatgag aatgttgcgc atgttctact ggaaggacta catcatcaaa 3180
gacccaaacg ttatttcacc atagtgatta tttcaagtag cttgctactt ggacttattg 3240
tacttctatt gatctcatat gttatgtgga aggctggctt ctttaaaaga caatacaaat 3300
ctatcctaca agaagaaaac agaagagaca gttggagtta tatcaacagt aaaagcaatg 3360
atgattaagg acttctttca aattgagaga atggaaaaca gactcaggtt gtagtaaaga 3420
aatttaaaag acactgttta caagaaaaaa tgaattttgt ttggacttct tttactcatg 3480
atcttgtgac atattatgtc ttcatgcaag gggaaaatct cagcaatgat tactctttga 3540
gatagaagaa ctgcaaaggt aataatacag ccaaagataa tctctcagct tttaaatggg 3600
tagagaaaca ctaaagcatt caatttattc aagaaaagta agcccttgaa gatatcttga 3660
aatgaaagta taactgagtt aaattatact ggagaagtct tagacttgaa atactactta 3720
ccatatgtgc ttgcctcagt aaaatgaacc ccactgggtg ggcagaggtt catttcaaat 3780
acatctttga tacttgttca aaatatgttc tttaaaaata taatttttta gagagctgtt 3840
cccaaatttt ctaacgagtg gaccattatc actttaaagc cctttattta taatacattt 3900
cctacgggct gtgttccaac aaccattttt tttcagcaga ctatgaatat tatagtatta 3960
taggccaaac tggcaaactt cagactgaac atgtacactg gtttgagctt agtgaaatta 4020
cttctggata attatttttt tataattatg gatttcacca tctttctttc tgtatatata 4080
catgtgtttt tatgtaggta tatatttacc attcttccta tctattcttc ctataacaca 4140
cctttatcaa gcatacccag gagtaatctt caaatctttt gttatattct gaaacaaaag 4200
attgtgagtg ttgcacttta cctgatacac gctgatttag aaaatacaga aaccatacct 4260
cactaataac tttaaaatca aagctgtgca aagactaggg ggcctatact tcatatgtat 4320
tatgtactat gtaaaatatt gactatcaca caactatttc cttggatgta attctttgtt 4380
accctttaca agtataagtg ttaccttaca tggaaacgaa gaaacaaaat tcataaattt 4440
aaattcataa atttagctga aagatactga ttcaatttgt atacagtgaa tataaatgag 4500
acgacagcaa aattttcatg aaatgtaaaa tatttttata gtttgttcat actatatgag 4560
gttctatttt aaatgacttt ctggatttta aaaaatttct ttaaatacaa tcatttttgt 4620
aatatttatt ttatgcttat gatctagata attgcagaat atcattttat ctgactctgc 4680
cttcataaga gagctgtggc cgaattttga acatctgtta tagggagtga tcaaattaga 4740
aggcaatgtg gaaaaacaat tctgggaaag atttctttat atgaagtccc tgccactagc 4800
cagccatcct aattgatgaa agttatctgt tcacaggcct gcagtgatgg tgaggaatgt 4860
tctgagattt gcgaaggcat ttgagtagtg aaatgtaagc acaaaacctc ctgaacccag 4920
agtgtgtata cacaggaata aactttatga catttatgta tttttaaaaa actttgtatc 4980
gttataaaaa ggctagtcat tctttcagga gaacatctag gatcatagat gaaaaatcaa 5040
gccccgattt agaactgtct tctccaggat ggtctctaag gaaatttaca tttggttctt 5100
tcctactcag aactactcag aaacaactat atatttcagg ttatctgagc acagtgaaag 5160
cagagtacta tggttgtcca acacaggcct ctcagataca aggggaacac aattacatat 5220
tgggctagat tttgcccagt tcaaaatagt atttgttatc aacttacttt gttacttgta 5280
tcatgaattt taaaacccta ccactttaag aagacaggga tgggttattc ttttttggca 5340
ggtaggctat ataactatgt gattttgaaa tttaactgct ctggattagg gagcagtgaa 5400
tcaaggcaga cttatgaaat ctgtattata tttgtaacag aatataggaa atttaacata 5460
attgatgagc tcaaatcctg aaaaatgaaa gaatccaaat tatttcagaa ttatctaggt 5520
taaatattga tgtattatga tggttgcaaa gtttttttgt gtgtccaata aacacattgt 5580
aaaaaaaaga atttgaattg atatctaaaa acagaatttg aattgatatt tcatcttgac 5640
ttttaaagcc ctagaggcta attgttagta acatcaattt ctattaggat atccgtttgg 5700
ccacacagca ggaggttaga gcaatggagc attactgagt tcctccccct gtcagatcag 5760
cagcagcatt agattctcat agaagtgcga accatatggt gaactggtat gtgagggatc 5820
tagagtgcca tgttcctcaa gagaatctaa tgcctgatga tctgaggtgg aacagttcat 5880
cctgaaacca ttcccccatc cacggaaaaa ttgtcttcca tgaaactggt cccaaaaagg 5940
gtggggacca caggtttaaa gcatggccac atttctttat attaaaattc tagtttgtac 6000
atttctttta gaaacaatta catgttactt tggaatcatt tcttccatgc ttcctccata 6060
aagactgata agtcttggat gcaatctgta aagaaaatac attatttcat caacttattt 6120
tgttgttttt cacatacacc taataagtat ggtacacaat gccaatgcca aatacaaatt 6180
gataacaaac acagcattcc caacagagct gtaatctaga aaactgagaa ggtctgattg 6240
ataaatcatc aacaacaata attgctctaa aacctcctta actgacttcc ttgattgtcc 6300
aatgctctcc attacctctg taaaacagtc agttatgcct ctagaacacc catgtctagt 6360
gggcacccct gcatgcttct tctaaccact gagtgtcaca atgcctacca agaatgcgtt 6420
tgcaggttcc taaacctgtt tataccagtt gctatgtaaa attgttccca agggaagttg 6480
aatgctctgt aaaggcctaa taaaagcaaa ttactgaaca aaacatgtta cagtaattat 6540
gagtgagagg aaactaagat ggaaggataa aaatctaaca ctttactatt cagatggctc 6600
cactaaaaga tttaagatct tgatccattt ttaaaaatcc aaaatggaag ttgtagacat 6660
tatctgtagt ttatgcacaa caataaatta gaaagccaat gtagacacgc ataaccaaag 6720
aaaatgcctt gggtctacat aacagttgaa taaatgtaaa gttgcttttt atttattgaa 6780
a 6781
<210> 232
<211> 4267
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4267)
<223> ITGA5 mRNA
<400> 232
attcgcctct gggaggttta ggaagcggct ccgggtcggt ggccccagga cagggaagag 60
cgggcgctat ggggagccgg acgccagagt cccctctcca cgccgtgcag ctgcgctggg 120
gcccccggcg ccgacccccg ctgctgccgc tgctgttgct gctgctgccg ccgccaccca 180
gggtcggggg cttcaactta gacgcggagg ccccagcagt actctcgggg cccccgggct 240
ccttcttcgg attctcagtg gagttttacc ggccgggaac agacggggtc agtgtgctgg 300
tgggagcacc caaggctaat accagccagc caggagtgct gcagggtggt gctgtctacc 360
tctgtccttg gggtgccagc cccacacagt gcacccccat tgaatttgac agcaaaggct 420
ctcggctcct ggagtcctca ctgtccagct cagagggaga ggagcctgtg gagtacaagt 480
ccttgcagtg gttcggggca acagttcgag cccatggctc ctccatcttg gcatgcgctc 540
cactgtacag ctggcgcaca gagaaggagc cactgagcga ccccgtgggc acctgctacc 600
tctccacaga taacttcacc cgaattctgg agtatgcacc ctgccgctca gatttcagct 660
gggcagcagg acagggttac tgccaaggag gcttcagtgc cgagttcacc aagactggcc 720
gtgtggtttt aggtggacca ggaagctatt tctggcaagg ccagatcctg tctgccactc 780
aggagcagat tgcagaatct tattaccccg agtacctgat caacctggtt caggggcagc 840
tgcagactcg ccaggccagt tccatctatg atgacagcta cctaggatac tctgtggctg 900
ttggtgaatt cagtggtgat gacacagaag actttgttgc tggtgtgccc aaagggaacc 960
tcacttacgg ctatgtcacc atccttaatg gctcagacat tcgatccctc tacaacttct 1020
caggggaaca gatggcctcc tactttggct atgcagtggc cgccacagac gtcaatgggg 1080
acgggctgga tgacttgctg gtgggggcac ccctgctcat ggatcggacc cctgacgggc 1140
ggcctcagga ggtgggcagg gtctacgtct acctgcagca cccagccggc atagagccca 1200
cgcccaccct taccctcact ggccatgatg agtttggccg atttggcagc tccttgaccc 1260
ccctggggga cctggaccag gatggctaca atgatgtggc catcggggct ccctttggtg 1320
gggagaccca gcagggagta gtgtttgtat ttcctggggg cccaggaggg ctgggctcta 1380
agccttccca ggttctgcag cccctgtggg cagccagcca caccccagac ttctttggct 1440
ctgcccttcg aggaggccga gacctggatg gcaatggata tcctgatctg attgtggggt 1500
cctttggtgt ggacaaggct gtggtataca ggggccgccc catcgtgtcc gctagtgcct 1560
ccctcaccat cttccccgcc atgttcaacc cagaggagcg gagctgcagc ttagagggga 1620
accctgtggc ctgcatcaac cttagcttct gcctcaatgc ttctggaaaa cacgttgctg 1680
actccattgg tttcacagtg gaacttcagc tggactggca gaagcagaag ggaggggtac 1740
ggcgggcact gttcctggcc tccaggcagg caaccctgac ccagaccctg ctcatccaga 1800
atggggctcg agaggattgc agagagatga agatctacct caggaacgag tcagaatttc 1860
gagacaaact ctcgccgatt cacatcgctc tcaacttctc cttggacccc caagccccag 1920
tggacagcca cggcctcagg ccagccctac attatcagag caagagccgg atagaggaca 1980
aggctcagat cttgctggac tgtggagaag acaacatctg tgtgcctgac ctgcagctgg 2040
aagtgtttgg ggagcagaac catgtgtacc tgggtgacaa gaatgccctg aacctcactt 2100
tccatgccca gaatgtgggt gagggtggcg cctatgaggc tgagcttcgg gtcaccgccc 2160
ctccagaggc tgagtactca ggactcgtca gacacccagg gaacttctcc agcctgagct 2220
gtgactactt tgccgtgaac cagagccgcc tgctggtgtg tgacctgggc aaccccatga 2280
aggcaggagc cagtctgtgg ggtggccttc ggtttacagt ccctcatctc cgggacacta 2340
agaaaaccat ccagtttgac ttccagatcc tcagcaagaa tctcaacaac tcgcaaagcg 2400
acgtggtttc ctttcggctc tccgtggagg ctcaggccca ggtcaccctg aacggtgtct 2460
ccaagcctga ggcagtgcta ttcccagtaa gcgactggca tccccgagac cagcctcaga 2520
aggaggagga cctgggacct gctgtccacc atgtctatga gctcatcaac caaggcccca 2580
gctccattag ccagggtgtg ctggaactca gctgtcccca ggctctggaa ggtcagcagc 2640
tcctatatgt gaccagagtt acgggactca actgcaccac caatcacccc attaacccaa 2700
agggcctgga gttggatccc gagggttccc tgcaccacca gcaaaaacgg gaagctccaa 2760
gccgcagctc tgcttcctcg ggacctcaga tcctgaaatg cccggaggct gagtgtttca 2820
ggctgcgctg tgagctcggg cccctgcacc aacaagagag ccaaagtctg cagttgcatt 2880
tccgagtctg ggccaagact ttcttgcagc gggagcacca gccatttagc ctgcagtgtg 2940
aggctgtgta caaagccctg aagatgccct accgaatcct gcctcggcag ctgccccaaa 3000
aagagcgtca ggtggccaca gctgtgcaat ggaccaaggc agaaggcagc tatggcgtcc 3060
cactgtggat catcatccta gccatcctgt ttggcctcct gctcctaggt ctactcatct 3120
acatcctcta caagcttgga ttcttcaaac gctccctccc atatggcacc gccatggaaa 3180
aagctcagct caagcctcca gccacctctg atgcctgagt cctcccaatt tcagactccc 3240
attcctgaag aaccagtccc cccaccctca ttctactgaa aaggaggggt ctgggtactt 3300
cttgaaggtg ctgacggcca gggagaagct cctctcccca gcccagagac atacttgaag 3360
ggccagagcc aggggggtga ggagctgggg atccctcccc cccatgcact gtgaaggacc 3420
cttgtttaca cataccctct tcatggatgg gggaactcag atccagggac agaggcccca 3480
gcctccctga agcctttgca ttttggagag tttcctgaaa caacttggaa agataactag 3540
gaaatccatt cacagttctt tgggccagac atgccacaag gacttcctgt ccagctccaa 3600
cctgcaaaga tctgtcctca gccttgccag agatccaaaa gaagccccca gctaagaacc 3660
tggaacttgg ggagttaaga cctggcagct ctggacagcc ccaccctggt gggccaacaa 3720
agaacactaa ctatgcatgg tgccccagga ccagctcagg acagatgcca cacaaggata 3780
gatgctggcc cagggcccag agcccagctc caaggggaat cagaactcaa atggggccag 3840
atccagcctg gggtctggag ttgatctgga acccagactc agacattggc acctaatcca 3900
ggcagatcca ggactatatt tgggcctgct ccagacctga tcctggaggc ccagttcacc 3960
ctgatttagg agaagccagg aatttcccag gaccctgaag gggccatgat ggcaacagat 4020
ctggaacctc agcctggcca gacacaggcc ctccctgttc cccagagaaa ggggagccca 4080
ctgtcctggg cctgcagaat ttgggttctg cctgccagct gcactgatgc tgcccctcat 4140
ctctctgccc aacccttccc tcaccttggc accagacacc caggacttat ttaaactctg 4200
ttgcaagtgc aataaatctg acccagtgcc cccactgacc agaactagaa aaaaaaaaaa 4260
aaaaaaa 4267
<210> 233
<211> 7039
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(7039)
<223> ITGAV mRNA
<400> 233
agtccccagc ctcagacgct gcgtggagcg gcggagccgg agggaagcaa aggaccgtct 60
gcgctgctgt ccccgccccg cgcgctctgc gcccctcgtc cctggcggtc gctccgaagc 120
tcagccctct tgcctgcccc ggagctgtcc cgggctagcc gagaagagag cggccggcaa 180
gtttgggcgc gcgcaggcgg cgggccgcgg gcactgggcg cctcgctggg gcggggggag 240
gtggctaccg ctcccggctt ggcgtcccgc gcgcacttcg gcgatggctt ttccgccgcg 300
gcgacggctg cgcctcggtc cccgcggcct cccgcttctt ctctcgggac tcctgctacc 360
tctgtgccgc gccttcaacc tagacgtgga cagtcctgcc gagtactctg gccccgaggg 420
aagttacttc ggcttcgccg tggatttctt cgtgcccagc gcgtcttccc ggatgtttct 480
tctcgtggga gctcccaaag caaacaccac ccagcctggg attgtggaag gagggcaggt 540
cctcaaatgt gactggtctt ctacccgccg gtgccagcca attgaatttg atgcaacagg 600
caatagagat tatgccaagg atgatccatt ggaatttaag tcccatcagt ggtttggagc 660
atctgtgagg tcgaaacagg ataaaatttt ggcctgtgcc ccattgtacc attggagaac 720
tgagatgaaa caggagcgag agcctgttgg aacatgcttt cttcaagatg gaacaaagac 780
tgttgagtat gctccatgta gatcacaaga tattgatgct gatggacagg gattttgtca 840
aggaggattc agcattgatt ttactaaagc tgacagagta cttcttggtg gtcctggtag 900
cttttattgg caaggtcagc ttatttcgga tcaagtggca gaaatcgtat ctaaatacga 960
ccccaatgtt tacagcatca agtataataa ccaattagca actcggactg cacaagctat 1020
ttttgatgac agctatttgg gttattctgt ggctgtcgga gatttcaatg gtgatggcat 1080
agatgacttt gtttcaggag ttccaagagc agcaaggact ttgggaatgg tttatattta 1140
tgatgggaag aacatgtcct ccttatacaa ttttactggc gagcagatgg ctgcatattt 1200
cggattttct gtagctgcca ctgacattaa tggagatgat tatgcagatg tgtttattgg 1260
agcacctctc ttcatggatc gtggctctga tggcaaactc caagaggtgg ggcaggtctc 1320
agtgtctcta cagagagctt caggagactt ccagacgaca aagctgaatg gatttgaggt 1380
ctttgcacgg tttggcagtg ccatagctcc tttgggagat ctggaccagg atggtttcaa 1440
tgatattgca attgctgctc catatggggg tgaagataaa aaaggaattg tttatatctt 1500
caatggaaga tcaacaggct tgaacgcagt cccatctcaa atccttgaag ggcagtgggc 1560
tgctcgaagc atgccaccaa gctttggcta ttcaatgaaa ggagccacag atatagacaa 1620
aaatggatat ccagacttaa ttgtaggagc ttttggtgta gatcgagcta tcttatacag 1680
ggccagacca gttatcactg taaatgctgg tcttgaagtg taccctagca ttttaaatca 1740
agacaataaa acctgctcac tgcctggaac agctctcaaa gtttcctgtt ttaatgttag 1800
gttctgctta aaggcagatg gcaaaggagt acttcccagg aaacttaatt tccaggtgga 1860
acttcttttg gataaactca agcaaaaggg agcaattcga cgagcactgt ttctctacag 1920
caggtcccca agtcactcca agaacatgac tatttcaagg gggggactga tgcagtgtga 1980
ggaattgata gcgtatctgc gggatgaatc tgaatttaga gacaaactca ctccaattac 2040
tatttttatg gaatatcggt tggattatag aacagctgct gatacaacag gcttgcaacc 2100
cattcttaac cagttcacgc ctgctaacat tagtcgacag gctcacattc tacttgactg 2160
tggtgaagac aatgtctgta aacccaagct ggaagtttct gtagatagtg atcaaaagaa 2220
gatctatatt ggggatgaca accctctgac attgattgtt aaggctcaga atcaaggaga 2280
aggtgcctac gaagctgagc tcatcgtttc cattccactg caggctgatt tcatcggggt 2340
tgtccgaaac aatgaagcct tagcaagact ttcctgtgca tttaagacag aaaaccaaac 2400
tcgccaggtg gtatgtgacc ttggaaaccc aatgaaggct ggaactcaac tcttagctgg 2460
tcttcgtttc agtgtgcacc agcagtcaga gatggatact tctgtgaaat ttgacttaca 2520
aatccaaagc tcaaatctat ttgacaaagt aagcccagtt gtatctcaca aagttgatct 2580
tgctgtttta gctgcagttg agataagagg agtctcgagt cctgatcatg tctttcttcc 2640
gattccaaac tgggagcaca aggagaaccc tgagactgaa gaagatgttg ggccagttgt 2700
tcagcacatc tatgagctga gaaacaatgg tccaagttca ttcagcaagg caatgctcca 2760
tcttcagtgg ccttacaaat ataataataa cactctgttg tatatccttc attatgatat 2820
tgatggacca atgaactgca cttcagatat ggagatcaac cctttgagaa ttaagatctc 2880
atctttgcaa acaactgaaa agaatgacac ggttgccggg caaggtgagc gggaccatct 2940
catcactaag cgggatcttg ccctcagtga aggagatatt cacactttgg gttgtggagt 3000
tgctcagtgc ttgaagattg tctgccaagt tgggagatta gacagaggaa agagtgcaat 3060
cttgtacgta aagtcattac tgtggactga gacttttatg aataaagaaa atcagaatca 3120
ttcctattct ctgaagtcgt ctgcttcatt taatgtcata gagtttcctt ataagaatct 3180
tccaattgag gatatcacca actccacatt ggttaccact aatgtcacct ggggcattca 3240
gccagcgccc atgcctgtgc ctgtgtgggt gatcatttta gcagttctag caggattgtt 3300
gctactggct gttttggtat ttgtaatgta caggatgggc ttttttaaac gggtccggcc 3360
acctcaagaa gaacaagaaa gggagcagct tcaacctcat gaaaatggtg aaggaaactc 3420
agaaacttaa ctgcagtttt taagttatgc tacatcttga cccactagaa ttagcaactt 3480
tattatagat ttaaactttc ttcatgagga gtaaaaatcc aaggctttac tgctgatagt 3540
gctaattggc attaaccaca aaatgagaat tatatttgtc aaccttctcc ttataaataa 3600
gttcagacat acatttaata acatagggtg acttgtgttt ttaggtattt aaataataaa 3660
atttcaaggg atagttttta ttcaatgtat ataagacagg tagtgcctga tttactactt 3720
tatataaaat agtacctcct tcagttactg tttctgattt aatgtacgga actttatttg 3780
ttgttgttgt tgttgttgtt gttgttgttt taaagcagtc caaatttgga ccttagcaat 3840
catgtctttt gtataggtac ttaatgttaa tacatattac actacagttt acttttcaga 3900
atactaaaga ctttataact gcatgaactt ggattttttt aatcactcat atggtagaat 3960
tttataaaca catacatgat accatccaaa ttcttgcttt taataacaaa ggtacaatat 4020
tttgttttag tatgaaaatc tggtagatcc tattacactt ctgtttatat taaatccaca 4080
atattttatt acatttttaa cttgtataaa ttttaggtca aatccttcaa gccaacctat 4140
actaaaaatt agttccataa tcacaaatgg ctcttttgtg taattgttta atttcacctg 4200
aatatcataa tgcttaaagc catatggagt tggaaattat ttccaaagca tatttattcc 4260
attgttttag tctggctatt tacagtataa aaaaagcatt tttattaaaa tactgtgtag 4320
ttctttgaga tagttgctta tgcatatagt aagtattaca ttcttagagt agagcagagt 4380
ttttagttag tattaattta ttttcctcca ttcatgtact tttccttata tttccaaaac 4440
tgttactgag aatgggtcaa gatcagtgag aaatctttac agttgacagg aacctggacc 4500
ccttacccca actttatgag taatgcttgg aataaaaact cttaaggcaa ctcactgatt 4560
tacttctagc aatagcatga tgttacagga atattacctc tgtttaagca aggtaatgtg 4620
taaaatcagt ctcggctgtc agaataactt ctaaaaggta tttttataag cagttcaagt 4680
tactgaaaac cttttaaacc tttctgaagt tcgttagtat aaattacttt tctaggatta 4740
ttaataaaag ccacataggt ggcaagttgt agttttatat ggctctgtag agtggtgaac 4800
cttctagagg aatatatgat ttattcacag ttcctcaagg cctggggatg atgatcagtt 4860
atacctattt ttgtgcaatt acatcatgtt gtacattaga aatggagagt ttaatagctc 4920
tttaactgct gtcctcatta ggtaatgata aatatttccc ttaaataatt gactattttg 4980
ctgtgtttta aaaatgattg aaatttatct tgccatatct cataatttca tgcacaagtt 5040
gactgagcta atcttgagaa tatattcgta aaataggagc acatttagtt gaggtataca 5100
aggtaggact ctagacaaaa ccttctattt tagctttagt gaatttcaaa agtaatgggt 5160
cttggagtat agatttttat tagtagcttg aaagagctta atcatatgca gtaagtattt 5220
ttattaccaa taaatttaaa attttttaag aaaaatattt ttatcctagg gccaagtgtt 5280
gcctgccacc aatcagtaag ttagtctata acaaatttta ccctaacagt tttaccacct 5340
agtaacagtc atttctgaaa atatgttgga tagaaagtca ctctttggca aaagtgttag 5400
aatttgcttt tgtgccatct attcctttta tggcatctat cttgaaagta atcttgtatt 5460
ggagattgaa agatgctgta atttagaaat taacatgata tcttaaatta cctttatgaa 5520
atatagtttt gtataatagc atagattttc cttcaaaaaa tgaacattta tatatctaca 5580
aaaatatgga gaagagtaat ttgaaagcct actttctgaa gaaaatggtg ggattttttt 5640
ttatcatgat taaatatcaa aaaattgccc tatgaaaact ttaaatctct aaaacatttg 5700
aaatactacc atatttgtga tttattgaga ataaaaatcc attttgaaat gtaaaatttt 5760
tatgatctga ttcagtttta agaaaacatg aatgaactag aagatattaa aaacatttga 5820
cattggtaag aaatattgat actgatattg atttttatat aggtatttat ttcagaattg 5880
atattttgag aaaaatacat gtgagtcatt ttttctgttt ctcttttctc ttaacgatta 5940
tcactgtaat tctgaatctg aaaggtaaaa caattagtca aaatattatt gccatcattc 6000
tacctgtgtt atgaaactac ttattcatag ttaattctca ttaacactta catttccata 6060
aagaaaactc aagtattaat aaaagagact ttactggctt aagagggctg tgaaagattt 6120
ttgatagtga atcatgaccc taagggagag atttgtgtga taaaagtatt gtatataata 6180
gatcagcgat ttttgtaagg caaacagaat ttgtaagttg gcagatcttc ctaagttgca 6240
aaatgtaatg atgagcttgg tggagaagaa tgagtcgttc ttggaatacc tatgtgcagc 6300
cactacccat ctcaatgtca ccttgtttgc attcttggat agcttgtata tgtagtagtt 6360
tgatgaataa tttaaagaaa aacacctaaa atttgaaaaa tgattgtagg atcaaaaaag 6420
gcagatgaaa ttacttaata ctcagtgttt tggagagtat tccttttagt ttgttggttg 6480
gctggtttga acgatagaaa tatgcagcat gcaatatatg cttatatttc attttaattt 6540
ctgatatata atgaacttct tgggagaggt actgaatctt tgatgttttt tgtcattgtt 6600
ctcaagtgca atataacaat gtaaccaaat ctagataatt tcaaagttgt cattaattta 6660
gtaagcctaa tataaacaaa tatttgtatt atttttgtta gcaggaaaga gtgattaagt 6720
gaggttattt acccctaaat ggtccattct gcattgtatt tcaggctgga aatgaattat 6780
tctttaccag ttttgaaaca ctttgaaata tcctaaggta acttggaagc tgtgtagtat 6840
atcaaattaa tttgctacct aataacatag aaagtaaata tctttgtggt cacccacatt 6900
gggtgagaca gaaaatgaat ctgttctaaa atttgtaatt tgctaacttg atttgagtta 6960
gtgaaaactg gtacagtgtt ctgcttgatt tacaacatgt aacttgtgac tgtacaataa 7020
acataagcat atggtacca 7039
<210> 234
<211> 3739
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3739)
<223> ITGB1 mRNA
<400> 234
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct 60
caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa 120
gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact 180
tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata 240
gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa 300
ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt 360
ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac 420
tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag 480
aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc 540
agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca 600
gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa 660
aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc 720
atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt 780
tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc 840
gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa 900
tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct 960
caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa 1020
tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta 1080
tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca 1140
gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac 1200
tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt 1260
ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct 1320
gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac 1380
atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga 1440
aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt 1500
gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac 1560
agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag 1620
agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt 1680
gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag 1740
tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa 1800
gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt 1860
acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt 1920
gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca 1980
tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc 2040
cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg 2100
ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat 2160
ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt 2220
gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga 2280
agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gcaagaaaat 2340
ccgatttaca agagtcctat taataatttc aagaatccaa actacggacg taaagctggt 2400
ctctaaattg ccggtgaaaa tcctatttat aagagtgccg taacaactgt ggtcaatccg 2460
aagtatgagg gaaaatgagt actgcccgtg caaatcccac aacactgaat gcaaagtagc 2520
aatttccata gtcacagtta ggtagcttta gggcaatatt gccatggttt tactcatgtg 2580
caggttttga aaatgtacaa tatgtataat ttttaaaatg ttttattatt ttgaaaataa 2640
tgttgtaatt catgccaggg actgacaaaa gacttgagac aggatggtta ctcttgtcag 2700
ctaaggtcac attgtgcctt tttgaccttt tcttcctgga ctattgaaat caagcttatt 2760
ggattaagtg atatttctat agcgattgaa agggcaatag ttaaagtaat gagcatgatg 2820
agagtttctg ttaatcatgt attaaaactg atttttagct ttacaaatat gtcagtttgc 2880
agttatgcag aatccaaagt aaatgtcctg ctagctagtt aaggattgtt ttaaatctgt 2940
tattttgcta tttgcctgtt agacatgact gatgacatat ctgaaagaca agtatgttga 3000
gagttgctgg tgtaaaatac gtttgaaata gttgatctac aaaggccatg ggaaaaattc 3060
agagagttag gaaggaaaaa ccaatagctt taaaacctgt gtgccatttt aagagttact 3120
taatgtttgg taacttttat gccttcactt tacaaattca agccttagat aaaagaaccg 3180
agcaattttc tgctaaaaag tccttgattt agcactattt acatacaggc catactttac 3240
aaagtatttg ctgaatgggg accttttgag ttgaatttat tttattattt ttattttgtt 3300
taatgtctgg tgctttctgt cacctcttct aatcttttaa tgtatttgtt tgcaattttg 3360
gggtaagact ttttttatga gtactttttc tttgaagttt tagcggtcaa tttgcctttt 3420
taatgaacat gtgaagttat actgtggcta tgcaacagct ctcacctacg cgagtcttac 3480
tttgagttag tgccataaca gaccactgta tgtttacttc tcaccatttg agttgcccat 3540
cttgtttcac actagtcaca ttcttgtttt aagtgccttt agttttaaca gttcactttt 3600
tacagtgcta tttactgaag ttatttatta aatatgccta aaatacttaa atcggatgtc 3660
ttgactctga tgtattttat caggttgtgt gcatgaaatt tttatagatt aaagaagttg 3720
aggaaaagca aaaaaaaaa 3739
<210> 235
<211> 4894
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4894)
<223> ITGB3 mRNA
<400> 235
cgccgcggga ggcggacgag atgcgagcgc ggccgcggcc ccggccgctc tgggcgactg 60
tgctggcgct gggggcgctg gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc 120
gaggtgtgag ctcctgccag cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg 180
atgaggccct gcctctgggc tcacctcgct gtgacctgaa ggagaatctg ctgaaggata 240
actgtgcccc agaatccatc gagttcccag tgagtgaggc ccgagtacta gaggacaggc 300
ccctcagcga caagggctct ggagacagct cccaggtcac tcaagtcagt ccccagagga 360
ttgcactccg gctccggcca gatgattcga agaatttctc catccaagtg cggcaggtgg 420
aggattaccc tgtggacatc tactacttga tggacctgtc ttactccatg aaggatgatc 480
tgtggagcat ccagaacctg ggtaccaagc tggccaccca gatgcgaaag ctcaccagta 540
acctgcggat tggcttcggg gcatttgtgg acaagcctgt gtcaccatac atgtatatct 600
ccccaccaga ggccctcgaa aacccctgct atgatatgaa gaccacctgc ttgcccatgt 660
ttggctacaa acacgtgctg acgctaactg accaggtgac ccgcttcaat gaggaagtga 720
agaagcagag tgtgtcacgg aaccgagatg ccccagaggg tggctttgat gccatcatgc 780
aggctacagt ctgtgatgaa aagattggct ggaggaatga tgcatcccac ttgctggtgt 840
ttaccactga tgccaagact catatagcat tggacggaag gctggcaggc attgtccagc 900
ctaatgacgg gcagtgtcat gttggtagtg acaatcatta ctctgcctcc actaccatgg 960
attatccctc tttggggctg atgactgaga agctatccca gaaaaacatc aatttgatct 1020
ttgcagtgac tgaaaatgta gtcaatctct atcagaacta tagtgagctc atcccaggga 1080
ccacagttgg ggttctgtcc atggattcca gcaatgtcct ccagctcatt gttgatgctt 1140
atgggaaaat ccgttctaaa gtagagctgg aagtgcgtga cctccctgaa gagttgtctc 1200
tatccttcaa tgccacctgc ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg 1260
gactcaagat tggagacacg gtgagcttca gcattgaggc caaggtgcga ggctgtcccc 1320
aggagaagga gaagtccttt accataaagc ccgtgggctt caaggacagc ctgatcgtcc 1380
aggtcacctt tgattgtgac tgtgcctgcc aggcccaagc tgaacctaat agccatcgct 1440
gcaacaatgg caatgggacc tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg 1500
gatcccagtg tgagtgctca gaggaggact atcgcccttc ccagcaggac gaatgcagcc 1560
cccgggaggg tcagcccgtc tgcagccagc ggggcgagtg cctctgtggt caatgtgtct 1620
gccacagcag tgactttggc aagatcacgg gcaagtactg cgagtgtgac gacttctcct 1680
gtgtccgcta caagggggag atgtgctcag gccatggcca gtgcagctgt ggggactgcc 1740
tgtgtgactc cgactggacc ggctactact gcaactgtac cacgcgtact gacacctgca 1800
tgtccagcaa tgggctgctg tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct 1860
gtatccagcc gggctcctat ggggacacct gtgagaagtg ccccacctgc ccagatgcct 1920
gcacctttaa gaaagaatgt gtggagtgta agaagtttga ccggggagcc ctacatgacg 1980
aaaatacctg caaccgttac tgccgtgacg agattgagtc agtgaaagag cttaaggaca 2040
ctggcaagga tgcagtgaat tgtacctata agaatgagga tgactgtgtc gtcagattcc 2100
agtactatga agattctagt ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc 2160
ccaagggccc tgacatcctg gtggtcctgc tctcagtgat gggggccatt ctgctcattg 2220
gccttgccgc cctgctcatc tggaaactcc tcatcaccat ccacgaccga aaagaattcg 2280
ctaaatttga ggaagaacgc gccagagcaa aatgggacac agccaacaac ccactgtata 2340
aagaggccac gtctaccttc accaatatca cgtaccgggg cacttaatga taagcagtca 2400
tcctcagatc attatcagcc tgtgccacga ttgcaggagt ccctgccatc atgtttacag 2460
aggacagtat ttgtggggag ggatttgggg ctcagagtgg ggtaggttgg gagaatgtca 2520
gtatgtggaa gtgtgggtct gtgtgtgtgt atgtgggggt ctgtgtgttt atgtgtgtgt 2580
gttgtgtgtg ggagtgtgta atttaaaatt gtgatgtgtc ctgataagct gagctcctta 2640
gcctttgtcc cagaatgcct cctgcaggga ttcttcctgc ttagcttgag ggtgactatg 2700
gagctgagca ggtgttcttc attacctcag tgagaagcca gctttcctca tcaggccatt 2760
gtccctgaag agaagggcag ggctgaggcc tctcattcca gaggaaggga caccaagcct 2820
tggctctacc ctgagttcat aaatttatgg ttctcaggcc tgactctcag cagctatggt 2880
aggaactgct gggcttggca gcccgggtca tctgtacctc tgcctccttt cccctccctc 2940
aggccgaagg aggagtcagg gagagctgaa ctattagagc tgcctgtgcc ttttgccatc 3000
ccctcaaccc agctatggtt ctctcgcaag ggaagtcctt gcaagctaat tctttgacct 3060
gttgggagtg aggatgtctg ggccactcag gggtcattca tggcctgggg gatgtaccag 3120
catctcccag ttcataatca caacccttca gatttgcctt attggcagct ctactctgga 3180
ggtttgttta gaagaagtgt gtcaccctta ggccagcacc atctctttac ctcctaattc 3240
cacaccctca ctgctgtaga catttgctat gagctgggga tgtctctcat gaccaaatgc 3300
ttttcctcaa agggagagag tgctattgta gagccagagg tctggcccta tgcttccggc 3360
ctcctgtccc tcatccatag cacctccaca tacctggccc tgtgccttgg tgtgctgtat 3420
ccatccatgg ggctgattgt atttaccttc tacctcttgg ctgccttgtg aaggaattat 3480
tcccatgagt tggctgggaa taagtgccag gatggaatga tgggtcagtt gtatcagcac 3540
gtgtggcctg ttcttctatg ggttggacaa cctcatttta actcagtctt taatctgaga 3600
ggccacagtg caattttatt ttatttttct catgatgagg ttttcttaac ttaaaagaac 3660
atgtatataa acatgcttgc attatatttg taaatttatg tgatggcaaa gaaggagagc 3720
ataggaaacc acacagactt gggcagggta cagacactcc cacttggcat cattcacagc 3780
aagtcactgg ccagtggctg gatctgtgag gggctctctc atgatagaag gctatgggga 3840
tagatgtgtg gacacattgg acctttcctg aggaagaggg actgttcttt tgtcccagaa 3900
aagcagtggc tccattggtg ttgacataca tccaacatta aaagccaccc ccaaatgccc 3960
aagaaaaaaa gaaagactta tcaacatttg ttccatgagc agaaaactgg agctctggcc 4020
tcagtgttac agctaaataa tctttaatta aggcaagtca ctttcttctt cttaaagctg 4080
ttttctagtt tgagaaatga tgggatttta gcagccagtc ttgaaggtct ctttcagtat 4140
caacattcta agatgctggg acttactgtg tcatcaaatg tgcggttaag attctctggg 4200
atattgatac tgtttgtgtt tttagttggg agatctgaga gacctggctt tggcaagagc 4260
agatgtcatt ccatatcacc tttctcaatg aaagtctcat tctatcctct ctccaaaccc 4320
gttttccaac atttgttaat agttacgtct ctcctgatgt agcacttaag cttcatttag 4380
ttattatttc tttcttcact ttgcacacat ttgcatccac atattaggga agaggaatcc 4440
ataagtagct gaaatatcta ttctgtatta ttgtgttaac attgagaata agccttggaa 4500
ttagatatgg ggcaatgact gagccctgtc tcacccatgg attactcctt actgtaggga 4560
atggcagtat ggtagaggga taaatagggg gcggggaggg atagtcatgg atccaagaag 4620
tccttagaaa tagtggcagg gaacaggtgt ggaagctcat gcctgtaatt ataaccttca 4680
gctactaaga caggtgtggt ggctcacgcc tgtgattata atcttcagtt actaagacag 4740
agtccatgag agtgttaatg ggacattttc tttagataag atgttttata tgaagaaact 4800
gtatcaaagg gggaagaaaa tgtatttaac aggtgaatca aatcaggaat cttgtctgag 4860
ctactggaat gaagttcaca ggtcttgaag acca 4894
<210> 236
<211> 4392
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4392)
<223> ITGB5 mRNA
<400> 236
gccgccgagc ggagccagcc cctcccctac ccggagcagc ccgctggggc cgtcccgagc 60
ggcgacacac taggagtccc ggccggccag ccagggcagc cgcggtcccg ggactcggcc 120
gtgagtgctg cgggacggat ggtggcggcg gggcgcgggc cagcgcgggc gccgtgagcc 180
ggagctgcgc gcggggcatg cggctgcggc ccccggccct cggcccccgc gctccggccc 240
cagccccggc cgccggcccc cgcggagtgc agcgaccgcg ccgccgctga gggaggcgcc 300
ccaccatgcc gcgggccccg gcgccgctgt acgcctgcct cctggggctc tgcgcgctcc 360
tgccccggct cgcaggtctc aacatatgca ctagtggaag tgccacctca tgtgaagaat 420
gtctgctaat ccacccaaaa tgtgcctggt gctccaaaga ggacttcgga agcccacggt 480
ccatcacctc tcggtgtgat ctgagggcaa accttgtcaa aaatggctgt ggaggtgaga 540
tagagagccc agccagcagc ttccatgtcc tgaggagcct gcccctcagc agcaagggtt 600
cgggctctgc aggctgggac gtcattcaga tgacaccaca ggagattgcc gtgaacctcc 660
ggcccggtga caagaccacc ttccagctac aggttcgcca ggtggaggac tatcctgtgg 720
acctgtacta cctgatggac ctctccctgt ccatgaagga tgacttggac aatatccgga 780
gcctgggcac caaactcgcg gaggagatga ggaagctcac cagcaacttc cggttgggat 840
ttgggtcttt tgttgataag gacatctctc ctttctccta cacggcaccg aggtaccaga 900
ccaatccgtg cattggttac aagttgtttc caaattgcgt cccctccttt gggttccgcc 960
atctgctgcc tctcacagac agagtggaca gcttcaatga ggaagttcgg aaacagaggg 1020
tgtcccggaa ccgagatgcc cctgaggggg gctttgatgc agtactccag gcagccgtct 1080
gcaaggagaa gattggctgg cgaaaggatg cactgcattt gctggtgttc acaacagatg 1140
atgtgcccca catcgcattg gatggaaaat tgggaggcct ggtgcagcca cacgatggcc 1200
agtgccacct gaacgaggcc aacgagtaca ctgcatccaa ccagatggac tatccatccc 1260
ttgccttgct tggagagaaa ttggcagaga acaacatcaa cctcatcttt gcagtgacaa 1320
aaaaccatta tatgctgtac aagaatttta cagccctgat acctggaaca acggtggaga 1380
ttttagatgg agactccaaa aatattattc aactgattat taatgcatac aatagtatcc 1440
ggtctaaagt ggagttgtca gtctgggatc agcctgagga tcttaatctc ttctttactg 1500
ctacctgcca agatggggta tcctatcctg gtcagaggaa gtgtgagggt ctgaagattg 1560
gggacacggc atcttttgaa gtatcattgg aggcccgaag ctgtcccagc agacacacgg 1620
agcatgtgtt tgccctgcgg ccggtgggat tccgggacag cctggaggtg ggggtcacct 1680
acaactgcac gtgcggctgc agcgtggggc tggaacccaa cagcgccagg tgcaacggga 1740
gcgggaccta tgtctgcggc ctgtgtgagt gcagccccgg ctacctgggc accaggtgcg 1800
agtgccagga tggggagaac cagagcgtgt accagaacct gtgccgggag gcagagggca 1860
agccactgtg cagcgggcgt ggggactgca gctgcaacca gtgctcctgc ttcgagagcg 1920
agtttggcaa gatctatggg cctttctgtg agtgcgacaa cttctcctgt gccaggaaca 1980
agggagtcct ctgctcaggc catggcgagt gtcactgcgg ggaatgcaag tgccatgcag 2040
gttacatcgg ggacaactgt aactgctcga cagacatcag cacatgccgg ggcagagatg 2100
gccagatctg cagcgagcgt gggcactgtc tctgtgggca gtgccaatgc acggagccgg 2160
gggcctttgg ggagatgtgt gagaagtgcc ccacctgccc ggatgcatgc agcaccaaga 2220
gagattgcgt cgagtgcctg ctgctccact ctgggaaacc tgacaaccag acctgccaca 2280
gcctatgcag ggatgaggtg atcacatggg tggacaccat cgtgaaagat gaccaggagg 2340
ctgtgctatg tttctacaaa accgccaagg actgcgtcat gatgttcacc tatgtggagc 2400
tccccagtgg gaagtccaac ctgaccgtcc tcagggagcc agagtgtgga aacaccccca 2460
acgccatgac catcctcctg gctgtggtcg gtagcatcct ccttgttggg cttgcactcc 2520
tggctatctg gaagctgctt gtcaccatcc acgaccggag ggagtttgca aagtttcaga 2580
gcgagcgatc cagggcccgc tatgaaatgg cttcaaatcc attatacaga aagcctatct 2640
ccacgcacac tgtggacttc accttcaaca agttcaacaa atcctacaat ggcactgtgg 2700
actgatgttt ccttctccga ggggctggag cggggatctg atgaaaaggt cagactgaaa 2760
cgccttgcac ggctgctcgg cttgatcaca gctccctagg taggcaccac agagaagacc 2820
ttctagtgag cctgggccag gagcccacag tgcctgtaca ggaaggtgcc tggccatgtc 2880
acctggctgc taggccagag ccatgccagg ctgcgtccct ccgagcttgg gataaagcaa 2940
ggggaccttg gcgctctcag ctttccctgc cacatccagc ttgttgtccc aatgaaatac 3000
tgagatgctg ggctgtctct cccttccagg aatgctgggc ccccagcctg gccagacaag 3060
aagactgtca ggaagggtcg gagtctgtaa aaccagcata cagtttggct tttttcacat 3120
tgatcatttt tatatgaaat aaaaagatcc tgcatttatg gtgtagttct gagtcctgag 3180
acttttctgc gtgatggcta tgccttgcac acaggtgttg gtgatggggc tgttgagatg 3240
cctgttgaag gtacatcgtt tgcaaatgtc agtttcctct cctgtccgtg tttgtttagt 3300
acttttataa tgaaaagaaa caagattgtt tgggattgga agtaaagatt aaaaccaaaa 3360
gaatttgtgt ttgtctgata ctctctgtgt gtttctttct ttctgagcgg acttaaaatg 3420
gtgcccccag tggggattga agcggccgtg tacttcctca gggatgggac acaggctggt 3480
ctgatactcc agactgcagc ttgtcaagta agcatgaggt gctcggggca gtgagggctg 3540
tgcaaggggg aacactgagc agataccttt ggccccttcc agcttttact gacagagagt 3600
tccaggctag acaccataaa aaccacccct tgttctgagg ggctgaggct ggaaatagat 3660
tgtacagaca agcaagggtt gagtggtggt tcccacacga agtcatctct taatcatcat 3720
tagcaatagc agttcccttc caaggcctcc cctcactccc gaaacactta cgtcccatgc 3780
aggcccaatg caaaaaaaca catttgagct tttttcccgc agggccatga agtcccctta 3840
agttcccata tctaagatgg ttgactgacc ctctcccctt atgtacagaa gaggaaactg 3900
attctcagag aggggaagtg gcttgcccga gtgtttgtta ggaggttact gaatgacaaa 3960
ctgttcctaa gaccccatct catgctggcc agagggccag cctcctcatt cctgcttgct 4020
cttagaaaat ctttcactga tcattttttg tcactggaat aacttcaagg ttattatgct 4080
ttcattccaa atggatctgt cctcagctct ggacccaatt ccccttactt cattttggca 4140
aacactaagt caaatagtga aatgcctgtc actacataga acctattacc tggggcaaat 4200
acgaacagat tgagtttcct tcatcttgtg taaatatgat gaaacagaga cctggtaact 4260
tggtgacact gttaaaccct ttttgggata aagccaaatg taaatgaaaa cattaaacag 4320
ataaattgtg gtgttgagac ttttctgaat tgagaaaaat aaatgtaatt ttggaagaaa 4380
aaaaaaaaaa aa 4392
<210> 237
<211> 1183
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1183)
<223> KRTAP1-5 mRNA
<400> 237
aaacctcaga aactcctcca agcaacctaa ctcttaaccc aacttctgac accatgacct 60
gctgccagac cagcttctgt ggatatccca gcttctccat cagtgggacc tgtggctcca 120
gctgctgcca gccaagctgc tgtgagacca gctgctgcca gccacgcagc tgccagacta 180
gcttctgcgg atttcccagc ttctcaacca gtgggacctg cagctccagt tgctgccagc 240
caagctgctg tgagaccagc tgctgccagc caagctgctg tgagaccagc tgctgccagc 300
caagctgctg ccagatcagc tcctgcggaa ctggctgtgg cattggtggt ggcatcagct 360
atggccagga gggcagcagt ggagctgtga gcacccgtat caggtggtgc cgcccagaca 420
gtcgtgtgga gggcacctac ctacccccct gctgtgtggt gagctgcacg cccccatcct 480
gctgccaact gcaccatgcc caggcctcct gctgccgccc gtcctactgt ggacagtcct 540
gctgccgccc agtctgctgc tgtgagccca cttgctgaaa gccagtttgc ttattttcaa 600
ttgcctaggt cacagtgtct ctgaactgtt catcccttga ccacctctgg accactaaca 660
agttctcaga ctttgcattg cttgtgatgg agactactaa gtatatgagc tcacaattct 720
atctgattcc attctacaat gaataccttg acccttcact ggggacacag aaatgctaca 780
aagccacctg ctgatcatca atttgcttgg gatatactat ttctgatatt tctgcaggat 840
taaaaattac tgacatgttg tggaatttat ccatgagaac tatccacaag tctaatgttt 900
ccatgcttta taatctattt tatcttgttt acctaaaatt ttttgcaaca tcaaagacac 960
caaattatag ccaagtgaca ttcctcaagt caccagagag aatggaagct catcacccaa 1020
cattcagctt ctaagaagta ggctggactt tccacatttt aacatctgat ccatcccttg 1080
gtttttggat cataatgatc ttgcctgctg gatatttcag ttatatctgt gatacaatgt 1140
cttctgtcat ttcttaataa atattatata ctaggcaaag aaa 1183
<210> 238
<211> 1965
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1965)
<223> LPXN mRNA
<400> 238
aggtcgcgac gcgtgccgta catccgggct caagcgtcga gccaattgct ggtctgatgg 60
gagggttttt cctacttttt cttacttttt atctgggcgt tggcgtacct ttctcggggt 120
gtctgcgtaa ctgcccagac ttgccttggt ttggtcagat gacacctcct ctgggactgg 180
ctagccagcg ttcatgtcta cattattgat ctcgtcttcc gatgccttat tggaggaact 240
ggaacgctcc acccttcagg acagtgatga atattccaac ccagctcctc ttcccctgga 300
tcagcattcc agaaaggaga ctaaccttga tgagacttcg gagatccttt ctattcagga 360
taacacaagt cccttgccgg cgcagctcgt gtatactacc aatatccagg agctcaatgt 420
ctacagtgaa gcccaagagc caaaggaatc accaccacct tctaaaacgt cagcagctgc 480
tcagttggat gagctcatgg ctcacctgac tgagatgcag gccaaggttg cagtgagagc 540
agatgctggc aagaagcact taccagacaa gcaggatcac aaggcctccc tggactcaat 600
gcttgggggt ctggagcagg aattgcagga ccttggcatt gccacagtgc ccaagggcca 660
ttgtgcatcc tgccagaaac cgattgctgg gaaggtgatc catgctctag ggcaatcatg 720
gcatcctgag cattttgtct gtactcattg caaagaagag attggctcca gtcccttctt 780
tgagcggagt ggcttggcct actgccccaa cgactaccac caactttttt ctccacgctg 840
tgcttactgc gctgctccca tcctggataa agtgctgaca gcaatgaacc agacctggca 900
cccagagcac ttcttctgct ctcactgcgg agaggtgttt ggtgcagaag gctttcatga 960
gaaggacaag aagccatatt gccgaaagga tttcttagcc atgttctcac ccaagtgtgg 1020
tggctgcaat cgcccagtgt tggaaaacta cctttcagcc atggacactg tctggcaccc 1080
agagtgcttt gtttgtgggg actgcttcac cagtttttct actggctcct tctttgaact 1140
ggatggacgt ccattctgtg agctccatta ccatcaccgc cggggaacgc tctgccatgg 1200
gtgtgggcag cccatcactg gccgttgtat cagtgccatg gggtacaagt tccatcctga 1260
gcactttgtg tgtgctttct gcctgacaca gttgtcgaag ggcattttca gggagcagaa 1320
tgacaagacc tattgtcaac cttgcttcaa taagctcttc ccactgtaat gccaactgat 1380
ccatagcctc ttcagattcc ttataaaatt taaaccaaga gaggagagga aagggtaaat 1440
tttctgttac tgaccttctg cttaatagtc ttatagaaaa aggaaaggtg atgagcaaat 1500
aaaggaactt ctagacttta catgactagg ctgataatct tattttttag gcttctatac 1560
agttaattct ataaattctc tttctccctc tcttctccaa tcaagcactt ggagttagat 1620
ctaggtcctt ctatctcgtc cctctacaga tgtattttcc acttgcataa ttcatgccaa 1680
cactggtttt cttaggtttc tccattttca cctctagtga tggccctact catatcttct 1740
ctaatttggt cctgatactt gtttcttttc acgttttccc atttccctgt ggctcactgt 1800
cttacaatca ctgctgtgga atcatgatac cacttttagc tctttgcatc ttccttcagt 1860
gtatttttgt ttttcaagag gaagtagatt ttaactggac aactttgagt actgacatca 1920
ttgataaata aactggcttg tggtttcaat aaaaaaaaaa aaaaa 1965
<210> 239
<211> 1514
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1514)
<223> MAPK1 mRNA
<400> 239
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg 60
gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt 120
cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga 180
gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac 240
atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac 300
gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc 360
tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag 420
caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat 480
gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat 540
gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac 600
ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc 660
cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc 720
tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac 780
acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg 840
aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa 900
atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt 960
ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct 1020
aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca 1080
aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag 1140
aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt 1200
gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag 1260
gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct 1320
taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt 1380
ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct 1440
tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa 1500
aaaaaaaaaa aaaa 1514
<210> 240
<211> 1174
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1174)
<223> MAPK3 mRNA
<400> 240
ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg 60
ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca 120
ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga 180
ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta 240
catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg 300
cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg 360
ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct 420
gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac 480
tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct 540
ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct 600
aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct 660
ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac 720
gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga 780
catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg 840
caagcactac ctggatcagc tcaaccacat tctgggcatc ctgggctccc catcccagga 900
ggacctgaat tgtatcatca acatgaaggc ccgaaactac ctacagtctc tgccctccaa 960
gaccaaggtg gcttgggcca agcttttccc caagtcagac tccaaagccc ttgacctgct 1020
ggaccggatg ttaaccttta accccaataa acggatcaca gtggaggaag cgctggctca 1080
cccctacctg gagcagtact atgacccgac ggatgaggtg ggccagtccc cagcagcagt 1140
ggggctgggg gcaggggagc aggggggcac gtag 1174
<210> 241
<211> 3950
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3950)
<223> MCL1 mRNA
<400> 241
acttctcact tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca 60
ggcggcggcg gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc 120
tctactgtgg gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc 180
gacttttggc tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg 240
gcgcggtgat tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc 300
ggagggtcgc gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg 360
cgaggctgct tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc 420
cggccgctga cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc 480
tcgggaagcg gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca 540
ccagtacgga cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt 600
tgtaccggca gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca 660
aggacacaaa gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac 720
gacgggttgg ggatggcgtg cagcgcaacc acgagacggc cttccaaggc atgcttcgga 780
aactggacat caaaaacgaa gacgatgtga aatcgttgtc tcgagtgatg atccatgttt 840
tcagcgacgg cgtaacaaac tggggcagga ttgtgactct catttctttt ggtgcctttg 900
tggctaaaca cttgaagacc ataaaccaag aaagctgcat cgaaccatta gcagaaagta 960
tcacagacgt tctcgtaagg acaaaacggg actggctagt taaacaaaga ggctgggatg 1020
ggtttgtgga gttcttccat gtagaggacc tagaaggtgg catcaggaat gtgctgctgg 1080
cttttgcagg tgttgctgga gtaggagctg gtttggcata tctaataaga tagccttact 1140
gtaagtgcaa tagttgactt ttaaccaacc accaccacca ccaaaaccag tttatgcagt 1200
tggactccaa gctgtaactt cctagagttg caccctagca acctagccag aaaagcaagt 1260
ggcaagagga ttatggctaa caagaataaa tacatgggaa gagtgctccc cattgattga 1320
agagtcactg tctgaaagaa gcaaagttca gtttcagcaa caaacaaact ttgtttggga 1380
agctatggag gaggactttt agatttagtg aagatggtag ggtggaaaga cttaatttcc 1440
ttgttgagaa caggaaagtg gccagtagcc aggcaagtca tagaattgat tacccgccga 1500
attcattaat ttactgtagt gttaagagaa gcactaagaa tgccagtgac ctgtgtaaaa 1560
gttacaagta atagaactat gactgtaagc ctcagtactg tacaagggaa gcttttcctc 1620
tctctaatta gctttcccag tatacttctt agaaagtcca agtgttcagg acttttatac 1680
ctgttatact ttggcttggt ttccatgatt cttactttat tagcctagtt tatcaccaat 1740
aatacttgac ggaaggctca gtaattagtt atgaatatgg atatcctcaa ttcttaagac 1800
agcttgtaaa tgtatttgta aaaattgtat atatttttac agaaagtcta tttctttgaa 1860
acgaaggaag tatcgaattt acattagttt ttttcatacc cttttgaact ttgcaacttc 1920
cgtaattagg aacctgtttc ttacagcttt tctatgctaa actttgttct gttcagttct 1980
agagtgtata cagaacgaat tgatgtgtaa ctgtatgcag actggttgta gtggaacaaa 2040
tctgataact atgcaggttt aaattttctt atctgatttt ggtaagtatt ccttaggttt 2100
ttctttgaaa acctgggatt gagaggttga tgaatggaaa ttctttcact tcattatatg 2160
caagttttca ataattaggt ctaagtggag ttttaaggtt actgatgact tacaaataat 2220
gggctctgat tgggcaatac tcatttgagt tccttccatt tgacctaatt taactggtga 2280
aatttaaagt gaattcatgg gctcatcttt aaagctttta ctaaaagatt ttcagctgaa 2340
tggaactcat tagctgtgtg catataaaaa gatcacatca ggtggatgga gagacatttg 2400
atcccttgtt tgcttaataa attataaaat gatggcttgg aaaagcaggc tagtctaacc 2460
atggtgctat tattaggctt gcttgttaca cacacaggtc taagcctagt atgtcaataa 2520
agcaaatact tactgttttg tttctattaa tgattcccaa accttgttgc aagtttttgc 2580
attggcatct ttggatttca gtcttgatgt ttgttctatc agacttaacc ttttatttcc 2640
tgtccttcct tgaaattgct gattgttctg ctccctctac agatatttat atcaattcct 2700
acagctttcc cctgccatcc ctgaactctt tctagccctt ttagattttg gcactgtgaa 2760
acccctgctg gaaacctgag tgaccctccc tccccaccaa gagtccacag acctttcatc 2820
tttcacgaac ttgatcctgt tagcaggtgg taataccatg ggtgctgtga cactaacagt 2880
cattgagagg tgggaggaag tcccttttcc ttggactggt atcttttcaa ctattgtttt 2940
atcctgtctt tgggggcaat gtgtcaaaag tcccctcagg aattttcaga ggaaagaaca 3000
ttttatgagg ctttctctaa agtttccttt gtataggagt atgctcactt aaatttacag 3060
aaagaggtga gctgtgttaa acctcagagt ttaaaagcta ctgataaact gaagaaagtg 3120
tctatattgg aactagggtc atttgaaagc ttcagtctcg gaacatgacc tttagtctgt 3180
ggactccatt taaaaatagg tatgaataag atgactaaga atgtaatggg gaagaactgc 3240
cctgcctgcc catctcagag ccataaggtc atctttgcta gagctatttt tacctatgta 3300
tttatcgttc ttgatcataa gccgcttatt tatatcatgt atctctaagg acctaaaagc 3360
actttatgta gtttttaatt aatcttaaga tctggttacg gtaactaaaa aagcctgtct 3420
gccaaatcca gtggaaacaa gtgcatagat gtgaattggt ttttaggggc cccacttccc 3480
aattcattag gtatgactgt ggaaatacag acaaggatct tagttgatat tttgggcttg 3540
gggcagtgag ggcttaggac accccaagtg gtttgggaaa ggaggagggg agtggtgggt 3600
ttataggggg aggaggaggc aggtggtcta agtgctgact ggctacgtag ttcgggcaaa 3660
tcctccaaaa gggaaaggga ggatttgctt agaaggatgg cgctcccagt gactactttt 3720
tgacttctgt ttgtcttacg cttctctcag ggaaaaacat gcagtcctct agtgtttcat 3780
gtacattctg tggggggtga acaccttggt tctggttaaa cagctgtact tttgatagct 3840
gtgccaggaa gggttaggac caactacaaa ttaatgttgg ttgtcaaatg tagtgtgttt 3900
ccctaacttt ctgtttttcc tgagaaaaaa aaataaatct tttattcaaa 3950
<210> 242
<211> 561
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(561)
<223> MIF mRNA
<400> 242
accacagtgg tgtccgagaa gtcaggcacg tagctcagcg gcggccgcgg cgcgtgcgtc 60
tgtgcctctg cgcgggtctc ctggtccttc tgccatcatg ccgatgttca tcgtaaacac 120
caacgtgccc cgcgcctccg tgccggacgg gttcctctcc gagctcaccc agcagctggc 180
gcaggccacc ggcaagcccc cccagtacat cgcggtgcac gtggtcccgg accagctcat 240
ggccttcggc ggctccagcg agccgtgcgc gctctgcagc ctgcacagca tcggcaagat 300
cggcggcgcg cagaaccgct cctacagcaa gctgctgtgc ggcctgctgg ccgagcgcct 360
gcgcatcagc ccggacaggg tctacatcaa ctattacgac atgaacgcgg ccaatgtggg 420
ctggaacaac tccaccttcg cctaagagcc gcagggaccc acgctgtctg cgctggctcc 480
acccgggaac ccgccgcacg ctgtgttcta ggcccgccca ccccaacctt ctggtgggga 540
gaaataaacg gtttagagac t 561
<210> 243
<211> 1971
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1971)
<223> MMP1 mRNA
<400> 243
atattggagc agcaagaggc tgggaagcca tcacttacct tgcactgaga aagaagacaa 60
aggccagtat gcacagcttt cctccactgc tgctgctgct gttctggggt gtggtgtctc 120
acagcttccc agcgactcta gaaacacaag agcaagatgt ggacttagtc cagaaatacc 180
tggaaaaata ctacaacctg aagaatgatg ggaggcaagt tgaaaagcgg agaaatagtg 240
gcccagtggt tgaaaaattg aagcaaatgc aggaattctt tgggctgaaa gtgactggga 300
aaccagatgc tgaaaccctg aaggtgatga agcagcccag atgtggagtg cctgatgtgg 360
ctcagtttgt cctcactgag gggaaccctc gctgggagca aacacatctg acctacagga 420
ttgaaaatta cacgccagat ttgccaagag cagatgtgga ccatgccatt gagaaagcct 480
tccaactctg gagtaatgtc acacctctga cattcaccaa ggtctctgag ggtcaagcag 540
acatcatgat atcttttgtc aggggagatc atcgggacaa ctctcctttt gatggacctg 600
gaggaaatct tgctcatgct tttcaaccag gcccaggtat tggaggggat gctcattttg 660
atgaagatga aaggtggacc aacaatttca gagagtacaa cttacatcgt gttgcagctc 720
atgaactcgg ccattctctt ggactctccc attctactga tatcggggct ttgatgtacc 780
ctagctacac cttcagtggt gatgttcagc tagctcagga tgacattgat ggcatccaag 840
ccatatatgg acgttcccaa aatcctgtcc agcccatcgg cccacaaacc ccaaaagcgt 900
gtgacagtaa gctaaccttt gatgctataa ctacgattcg gggagaagtg atgttcttta 960
aagacagatt ctacatgcgc acaaatccct tctacccgga agttgagctc aatttcattt 1020
ctgttttctg gccacaactg ccaaatgggc ttgaagctgc ttacgaattt gccgacagag 1080
atgaagtccg gtttttcaaa gggaataagt actgggctgt tcagggacag aatgtgctac 1140
acggataccc caaggacatc tacagctcct ttggcttccc tagaactgtg aagcatatcg 1200
atgctgctct ttctgaggaa aacactggaa aaacctactt ctttgttgct aacaaatact 1260
ggaggtatga tgaatataaa cgatctatgg atccaggtta tcccaaaatg atagcacatg 1320
actttcctgg aattggccac aaagttgatg cagttttcat gaaagatgga tttttctatt 1380
tctttcatgg aacaagacaa tacaaatttg atcctaaaac gaagagaatt ttgactctcc 1440
agaaagctaa tagctggttc aactgcagga aaaattgaac attactaatt tgaatggaaa 1500
acacatggtg tgagtccaaa gaaggtgttt tcctgaagaa ctgtctattt tctcagtcat 1560
ttttaacctc tagagtcact gatacacaga atataatctt atttatacct cagtttgcat 1620
atttttttac tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg 1680
gtgggtacaa aaagtcaagt ttgtggctta tggattcata taggccagag ttgcaaagat 1740
cttttccaga gtatgcaact ctgacgttga tcccagagag cagcttcagt gacaaacata 1800
tcctttcaag acagaaagag acaggagaca tgagtctttg ccggaggaaa agcagctcaa 1860
gaacacatgt gcagtcactg gtgtcaccct ggataggcaa gggataactc ttctaacaca 1920
aaataagtgt tttatgtttg gaataaagtc aaccttgttt ctactgtttt a 1971
<210> 244
<211> 3514
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3514)
<223> MMP2 mRNA
<400> 244
gctgcatcca gacttcctca ggcggtggct ggaggctgcg catctggggc tttaaacata 60
caaagggatt gccaggacct gcggcggcgg cggcggcggc gggggctggg gcgcgggggc 120
cggaccatga gccgctgagc cgggcaaacc ccaggccacc gagccagcgg accctcggag 180
cgcagccctg cgccgcggag caggctccaa ccaggcggcg aggcggccac acgcaccgag 240
ccagcgaccc ccgggcgacg cgcggggcca gggagcgcta cgatggaggc gctaatggcc 300
cggggcgcgc tcacgggtcc cctgagggcg ctctgtctcc tgggctgcct gctgagccac 360
gccgccgccg cgccgtcgcc catcatcaag ttccccggcg atgtcgcccc caaaacggac 420
aaagagttgg cagtgcaata cctgaacacc ttctatggct gccccaagga gagctgcaac 480
ctgtttgtgc tgaaggacac actaaagaag atgcagaagt tctttggact gccccagaca 540
ggtgatcttg accagaatac catcgagacc atgcggaagc cacgctgcgg caacccagat 600
gtggccaact acaacttctt ccctcgcaag cccaagtggg acaagaacca gatcacatac 660
aggatcattg gctacacacc tgatctggac ccagagacag tggatgatgc ctttgctcgt 720
gccttccaag tctggagcga tgtgacccca ctgcggtttt ctcgaatcca tgatggagag 780
gcagacatca tgatcaactt tggccgctgg gagcatggcg atggataccc ctttgacggt 840
aaggacggac tcctggctca tgccttcgcc ccaggcactg gtgttggggg agactcccat 900
tttgatgacg atgagctatg gaccttggga gaaggccaag tggtccgtgt gaagtatggg 960
aacgccgatg gggagtactg caagttcccc ttcttgttca atggcaagga gtacaacagc 1020
tgcactgata ccggccgcag cgatggcttc ctctggtgct ccaccaccta caactttgag 1080
aaggatggca agtacggctt ctgtccccat gaagccctgt tcaccatggg cggcaacgct 1140
gaaggacagc cctgcaagtt tccattccgc ttccagggca catcctatga cagctgcacc 1200
actgagggcc gcacggatgg ctaccgctgg tgcggcacca ctgaggacta cgaccgcgac 1260
aagaagtatg gcttctgccc tgagaccgcc atgtccactg ttggtgggaa ctcagaaggt 1320
gccccctgtg tcttcccctt cactttcctg ggcaacaaat atgagagctg caccagcgcc 1380
ggccgcagtg acggaaagat gtggtgtgcg accacagcca actacgatga tgaccgcaag 1440
tggggcttct gccctgacca agggtacagc ctgttcctcg tggcagccca cgagtttggc 1500
cacgccatgg ggctggagca ctcccaagac cctggggccc tgatggcacc catttacacc 1560
tacaccaaga acttccgtct gtcccaggat gacatcaagg gcattcagga gctctatggg 1620
gcctctcctg acattgacct tggcaccggc cccaccccca cgctgggccc tgtcactcct 1680
gagatctgca aacaggacat tgtatttgat ggcatcgctc agatccgtgg tgagatcttc 1740
ttcttcaagg accggttcat ttggcggact gtgacgccac gtgacaagcc catggggccc 1800
ctgctggtgg ccacattctg gcctgagctc ccggaaaaga ttgatgcggt atacgaggcc 1860
ccacaggagg agaaggctgt gttctttgca gggaatgaat actggatcta ctcagccagc 1920
accctggagc gagggtaccc caagccactg accagcctgg gactgccccc tgatgtccag 1980
cgagtggatg ccgcctttaa ctggagcaaa aacaagaaga catacatctt tgctggagac 2040
aaattctgga gatacaatga ggtgaagaag aaaatggatc ctggcttccc caagctcatc 2100
gcagatgcct ggaatgccat ccccgataac ctggatgccg tcgtggacct gcagggcggc 2160
ggtcacagct acttcttcaa gggtgcctat tacctgaagc tggagaacca aagtctgaag 2220
agcgtgaagt ttggaagcat caaatccgac tggctaggct gctgagctgg ccctggctcc 2280
cacaggccct tcctctccac tgccttcgat acaccgggcc tggagaacta gagaaggacc 2340
cggaggggcc tggcagccgt gccttcagct ctacagctaa tcagcattct cactcctacc 2400
tggtaattta agattccaga gagtggctcc tcccggtgcc caagaataga tgctgactgt 2460
actcctccca ggcgcccctt ccccctccaa tcccaccaac cctcagagcc acccctaaag 2520
agatactttg atattttcaa cgcagccctg ctttgggctg ccctggtgct gccacacttc 2580
aggctcttct cctttcacaa ccttctgtgg ctcacagaac ccttggagcc aatggagact 2640
gtctcaagag ggcactggtg gcccgacagc ctggcacagg gcagtgggac agggcatggc 2700
caggtggcca ctccagaccc ctggcttttc actgctggct gccttagaac ctttcttaca 2760
ttagcagttt gctttgtatg cactttgttt ttttctttgg gtcttgtttt ttttttccac 2820
ttagaaattg catttcctga cagaaggact caggttgtct gaagtcactg cacagtgcat 2880
ctcagcccac atagtgatgg ttcccctgtt cactctactt agcatgtccc taccgagtct 2940
cttctccact ggatggagga aaaccaagcc gtggcttccc gctcagccct ccctgcccct 3000
cccttcaacc attccccatg ggaaatgtca acaagtatga ataaagacac ctactgagtg 3060
gccgtgtttg ccatctgttt tagcagagcc tagacaaggg ccacagaccc agccagaagc 3120
ggaaacttaa aaagtccgaa tctctgctcc ctgcagggca caggtgatgg tgtctgctgg 3180
aaaggtcaga gcttccaaag taaacagcaa gagaacctca gggagagtaa gctctagtcc 3240
ctctgtcctg tagaaagagc cctgaagaat cagcaatttt gttgctttat tgtggcatct 3300
gttcgaggtt tgcttcctct ttaagtctgt ttcttcatta gcaatcatat cagttttaat 3360
gctactacta acaatgaaca gtaacaataa tatccccctc aattaataga gtgctttcta 3420
tgtgcaaggc acttttcacg tgtcacctat tttaaccttt ccaaccacat aaataaaaaa 3480
ggccattatt agttgaatct tattgatgaa gaga 3514
<210> 245
<211> 1906
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1906)
<223> MMP3 mRNA
<400> 245
aaagcaagga tgagtcaagc tgcgggtgat ccaaacaaac actgtcactc tttaaaagct 60
gcgctcccga ggttggacct acaaggaggc aggcaagaca gcaaggcata gagacaacat 120
agagctaagt aaagccagtg gaaatgaaga gtcttccaat cctactgttg ctgtgcgtgg 180
cagtttgctc agcctatcca ttggatggag ctgcaagggg tgaggacacc agcatgaacc 240
ttgttcagaa atatctagaa aactactacg acctcaaaaa agatgtgaaa cagtttgtta 300
ggagaaagga cagtggtcct gttgttaaaa aaatccgaga aatgcagaag ttccttggat 360
tggaggtgac ggggaagctg gactccgaca ctctggaggt gatgcgcaag cccaggtgtg 420
gagttcctga tgttggtcac ttcagaacct ttcctggcat cccgaagtgg aggaaaaccc 480
accttacata caggattgtg aattatacac cagatttgcc aaaagatgct gttgattctg 540
ctgttgagaa agctctgaaa gtctgggaag aggtgactcc actcacattc tccaggctgt 600
atgaaggaga ggctgatata atgatctctt ttgcagttag agaacatgga gacttttacc 660
cttttgatgg acctggaaat gttttggccc atgcctatgc ccctgggcca gggattaatg 720
gagatgccca ctttgatgat gatgaacaat ggacaaagga tacaacaggg accaatttat 780
ttctcgttgc tgctcatgaa attggccact ccctgggtct ctttcactca gccaacactg 840
aagctttgat gtacccactc tatcactcac tcacagacct gactcggttc cgcctgtctc 900
aagatgatat aaatggcatt cagtccctct atggacctcc ccctgactcc cctgagaccc 960
ccctggtacc cacggaacct gtccctccag aacctgggac gccagccaac tgtgatcctg 1020
ctttgtcctt tgatgctgtc agcactctga ggggagaaat cctgatcttt aaagacaggc 1080
acttttggcg caaatccctc aggaagcttg aacctgaatt gcatttgatc tcttcatttt 1140
ggccatctct tccttcaggc gtggatgccg catatgaagt tactagcaag gacctcgttt 1200
tcatttttaa aggaaatcaa ttctgggcta tcagaggaaa tgaggtacga gctggatacc 1260
caagaggcat ccacacccta ggtttccctc caaccgtgag gaaaatcgat gcagccattt 1320
ctgataagga aaagaacaaa acatatttct ttgtagagga caaatactgg agatttgatg 1380
agaagagaaa ttccatggag ccaggctttc ccaagcaaat agctgaagac tttccaggga 1440
ttgactcaaa gattgatgct gtttttgaag aatttgggtt cttttatttc tttactggat 1500
cttcacagtt ggagtttgac ccaaatgcaa agaaagtgac acacactttg aagagtaaca 1560
gctggcttaa ttgttgaaag agatatgtag aaggcacaat atgggcactt taaatgaagc 1620
taataattct tcacctaagt ctctgtgaat tgaaatgttc gttttctcct gcctgtgctg 1680
tgactcgagt cacactcaag ggaacttgag cgtgaatctg tatcttgccg gtcattttta 1740
tgttattaca gggcattcaa atgggctgct gcttagcttg caccttgtca catagagtga 1800
tctttcccaa gagaagggga agcactcgtg tgcaacagac aagtgactgt atctgtgtag 1860
actatttgct tatttaataa agacgatttg tcagttattt tatctt 1906
<210> 246
<211> 4593
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4593)
<223> VISFATIN mRNA
<400> 246
gctgccgcgc cccgcccttt ctcggccccc ggagggtgac ggggtgaagg cgggggaacc 60
gaggtgggga gtccgccaga gctcccagac tgcgagcacg cgagccgccg cagccgtcac 120
ccgcgccgcg tcacggctcc cgggcccgcc ctcctctgac ccctcccctc tctccgtttc 180
cccctctccc cctcctccgc cgaccgagca gtgacttaag caacggagcg cggtgaagct 240
catttttctc cttcctcgca gccgcgccag ggagctcgcg gcgcgcggcc cctgtcctcc 300
ggcccgagat gaatcctgcg gcagaagccg agttcaacat cctcctggcc accgactcct 360
acaaggttac tcactataaa caatatccac ccaacacaag caaagtttat tcctactttg 420
aatgccgtga aaagaagaca gaaaactcca aattaaggaa ggtgaaatat gaggaaacag 480
tattttatgg gttgcagtac attcttaata agtacttaaa aggtaaagta gtaaccaaag 540
agaaaatcca ggaagccaaa gatgtctaca aagaacattt ccaagatgat gtctttaatg 600
aaaagggatg gaactacatt cttgagaagt atgatgggca tcttccaata gaaataaaag 660
ctgttcctga gggctttgtc attcccagag gaaatgttct cttcacggtg gaaaacacag 720
atccagagtg ttactggctt acaaattgga ttgagactat tcttgttcag tcctggtatc 780
caatcacagt ggccacaaat tctagagagc agaagaaaat attggccaaa tatttgttag 840
aaacttctgg taacttagat ggtctggaat acaagttaca tgattttggc tacagaggag 900
tctcttccca agagactgct ggcataggag catctgctca cttggttaac ttcaaaggaa 960
cagatacagt agcaggactt gctctaatta aaaaatatta tggaacgaaa gatcctgttc 1020
caggctattc tgttccagca gcagaacaca gtaccataac agcttggggg aaagaccatg 1080
aaaaagatgc ttttgaacat attgtaacac agttttcatc agtgcctgta tctgtggtca 1140
gcgatagcta tgacatttat aatgcgtgtg agaaaatatg gggtgaagat ctaagacatt 1200
taatagtatc aagaagtaca caggcaccac taataatcag acctgattct ggaaaccctc 1260
ttgacactgt gttaaaggtt ttggagattt taggtaagaa gtttcctgtt actgagaact 1320
caaagggtta caagttgctg ccaccttatc ttagagttat tcaaggggat ggagtagata 1380
ttaatacctt acaagagatt gtagaaggca tgaaacaaaa aatgtggagt attgaaaata 1440
ttgccttcgg ttctggtgga ggtttgctac agaagttgac aagagatctc ttgaattgtt 1500
ccttcaagtg tagctatgtt gtaactaatg gccttgggat taacgtcttc aaggacccag 1560
ttgctgatcc caacaaaagg tccaaaaagg gccgattatc tttacatagg acgccagcag 1620
ggaattttgt tacactggag gaaggaaaag gagaccttga ggaatatggt caggatcttc 1680
tccatactgt cttcaagaat ggcaaggtga caaaaagcta ttcatttgat gaaataagaa 1740
aaaatgcaca gctgaatatt gaactggaag cagcacatca ttaggcttta tgactgggtg 1800
tgtgttgtgt gtatgtaata cataatgttt attgtacaga tgtgtggggt ttgtgtttta 1860
tgatacatta cagccaaatt atttgttggt ttatggacat actgcccttt catttttttt 1920
cttttccagt gtttaggtga tctcaaatta ggaaatgcat ttaaccatgt aaaagatgag 1980
tgctaaagta agctttttag ggccctttgc caataggtag tcattcaatc tggtattgat 2040
cttttcacaa ataacagaac tgagaaactt ttatatataa ctgatgatca cataaaacag 2100
atttgcataa aattaccatg attgctttat gtttatattt aacttgtatt tttgtacaaa 2160
caagattgtg taagatatat ttgaagtttc agtgatttaa cagtctttcc aacttttcat 2220
gatttttatg agcacagact ttcaagaaaa tacttgaaaa taaattacat tgccttttgt 2280
ccattaatca gcaaataaaa catggcctta acaaagttgt ttgtgttatt gtacaatttg 2340
aaaattatgt cgggacatac cctatagaat tactaacctt actgcccctt gtagaatatg 2400
tattaatcat tctacattaa agaaaataat ggttcttact ggaatgtcta ggcactgtac 2460
agttattata tatcttggtt gttgtattgt accagtgaaa tgccaaattt gaaaggcctg 2520
tactgcaatt ttatatgtca gagattgcct gtggctctaa tatgcacctc aagattttaa 2580
ggagataatg tttttagaga gaatttctgc ttccactata gaatatatac ataaatgtaa 2640
aatacttaca aaagtggaag tagtgtattt taaagtaatt acacttctga atttattttt 2700
catattctat agttggtatg acttaaatga attactggag tgggtagtga gtgtacttaa 2760
atgtttcaat tctgttatat tttttattaa gtttttaaaa aattaaattg gatattaaat 2820
tgtatggaca tcatttatta attttaaact gaatgccctc aataagtaat actgaagcac 2880
attcttaaat gaagataaat tatctccaat gaaaagcatg acatgtgttt caatagaaga 2940
atcttaagtt ggctaaattc aaagtgcttg acatcaaaat gttctagagt gattagctac 3000
tagattctga atcatacatc acatctgact agagaccagt ttctttcgaa tgattctttt 3060
atgtatgtag atctgttctt ctgaggcagc ggttggccaa ctatagccca aaggccaaat 3120
ttggacttct ttttataaat gcagattgtc tatggctgct ttcccactac tccagcctaa 3180
ggtaaacagc tgcaatagaa gccaaatgag aatcgcaaag cccaaaatgt ttattaacct 3240
gccctttaca caaaattaca caaaaagttt cctgatctct gttctaagaa aaggagtgtg 3300
ccttgcattt aaaaggaaat gttggtttct agggaaggga ggaggctaaa taattgatac 3360
ggaattttcc tcttttgtct tcttttttct cacttaagaa tccgatactg gaagactgat 3420
ttagaaaagt ttttaacatg acattaaatg tgaaatttta aaaattgaaa agccataaat 3480
catctgtttt aaatagttac atgagaaaat gatcactaga ataacctaat tagaagtgtt 3540
atcttcatta aatgtttttt gtaagtggta ttagaaagaa tatgtttttc agatggttct 3600
ttaaacatgt agtgagaaca ataagcatta ttcactttta gtaagtcttc tgtaatccat 3660
gatataaaat aattttaaaa tgatttttta atgtatttga gtaaagatga gtagtattaa 3720
gaaaaacaca catttcttca caaaatgtgc taaggggcgt gtaaagaatc aaaagaaact 3780
attaccaata atagttttga taatcaccca taattttgtg tttaaacatt gaaattatag 3840
tacagacagt attctctgtg ttctgtgaat ttcagcagct tcagaataga gtttaattta 3900
gaaatttgca gtgaaaaaag ctatctcttt gttcacaacc ataaatcagg agatggagat 3960
taattctatt ggctcttagt cacttggaac tgattaattc tgactttctg tcactaagca 4020
cttggtattt ggccatctcc attctgagca ccaaacggtt aacacgaatg tccactagaa 4080
ctctgctgtg tgtcaccctt aaatcagtct aaatcttcca gacaaaagca aatggcattt 4140
atggatttaa gtcattagat tttcaactga cattaattaa tccctcttga ttgattatat 4200
catcaagtat ttatatctta aataggaggt aggatttctg tgttaagact cttatttgta 4260
ccctataatt aaagtaaaat gttttttatg agtatccctt gttttccctt cttaaattgt 4320
tatcaaacaa tttttataat gaaatctatc ttggaaaatt agaaagaaaa atggcaaggt 4380
atttattgtt ctgtttgcca taatttagaa ctcacactta agtattttgt agttttacat 4440
tcctttttaa cccattcagt ggagaatgtc agcttttctc ccaagttgta tgttaagtct 4500
attctaatat gtactcaaca tcaagttata aacatgtaat aaacatggaa ataaagttta 4560
gctctattag tgaagtgtta aaaaaaaaaa aaa 4593
<210> 247
<211> 4020
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4020)
<223> NPAS2 mRNA
<400> 247
gcgtgcggaa gagtttgccg cgcgagcagc cggcctctcg caggagccga gggacccgcg 60
cggctgcggc ccaggagcgg cggccgcgga gcccggagac ccgcagccgc ggcggcggcg 120
gcggcggcgg cagcagctag agcagcgcct cccgccgccg cccgggagga gctcgccgcg 180
cccgctcgcc gcctcgtctc ccagcggcgg cgggaggcgc gtctccccgg cccagtccgc 240
gcccggcccc gcggggccgc tccggcccgc tccgaggaaa aactgcatag aaaatctaat 300
ggatgaagat gagaaagaca gagccaagag agcttctcga aacaagtctg agaagaagcg 360
tcgggaccag ttcaatgttc tcatcaaaga gctcagttcc atgctccctg gcaacacgcg 420
gaaaatggac aaaaccaccg tgttggaaaa ggtcatcgga tttttgcaga aacacaatga 480
agtctcagcg caaacggaaa tctgtgacat tcagcaagac tggaagcctt cattcctcag 540
taatgaagaa ttcacccagc tgatgttgga ggcattagat ggcttcatta tcgcagtgac 600
aacagacggc agcatcatct atgtctctga cagtatcacg cctctccttg ggcatttacc 660
gtcggatgtc atggatcaga atttgttaaa tttcctccca gaacaagaac attcagaagt 720
ttataaaatc ctttcttccc atatgcttgt gacggattcc ccctccccag aatacttaaa 780
atctgacagc gatttagagt tttattgcca tcttctcaga ggcagcttga acccaaagga 840
atttccaact tatgaataca taaaatttgt aggaaatttt cgctcttaca acaatgtgcc 900
tagcccctcc tgtaatggtt ttgacaacac cctttcaaga ccttgccggg tgccactagg 960
aaaggaggtt tgcttcattg ccaccgttcg tctggcaaca ccacaattct taaaggaaat 1020
gtgcatagtt gacgaacctt tagaggaatt cacttcaagg catagcttgg aatggaaatt 1080
tttatttctg gatcacagag cacctccaat cataggatac ctgccttttg aagtgctggg 1140
aacctcaggc tatgactact accacattga tgacctggag ctcctggcca ggtgtcacca 1200
gcacctgatg cagtttggca aagggaagtc gtgttgctac cggtttctga ccaaaggtca 1260
gcagtggatc tggctgcaga ctcactacta catcacctac catcagtgga actccaagcc 1320
cgagttcatc gtgtgcacac actcggtggt cagttacgca gatgtccggg tggaaaggag 1380
gcaggagctg gctctggaag acccgccatc cgaggccctc cactcctcag cactaaagga 1440
caagggctca agcctggaac ctcggcagca ctttaacaca ctcgacgtgg gtgcctcggg 1500
ccttaatacc agtcattcgc catcggcgtc ctcaagaagt tcccacaaat cctcgcacac 1560
agccatgtca gaacccacct ccactcccac caagctgatg gcagaggcca gcaccccggc 1620
tttgccaaga tcagccaccc tgccccaaga gttacctgtc cccgggctca gccaggcagc 1680
caccatgccg gcccctctgc cttccccatc gtcctgcgac ctcacacagc agctcctgcc 1740
tcagaccgtt ctgcagagca cgcccgctcc catggcacag ttttcggcac agttcagcat 1800
gttccagacc atcaaagacc agctagagca gcggacgcgg atcctgcagg ccaatatccg 1860
gtggcaacag gaagagctcc acaagatcca ggagcagctc tgcctggtcc aggactccaa 1920
cgtccagatg ttcctgcagc agccagctgt atccctgagc ttcagcagca cccagcgacc 1980
tgaggctcag cagcagctac agcaaaggtc agctgcagtg actcagcccc agctcggggc 2040
gggcccccaa cttccagggc agatctcctc tgcccaggtc acaagccagc acctgctcag 2100
agaatcaagt gtgatatcaa cccagggtcc aaagccaatg agaagctcac agctaatgca 2160
gagcagcggc cgctctggaa gcagcctagt gtccccgttc agcagcgcca cagctgcgct 2220
cccgccaagt ctgaatctga ccacacctgc ttccacctcc caggatgcca gccagtgcca 2280
gcccagccca gacttcagcc atgatcggca gctcaggctg ttgctgagcc agcccatcca 2340
gcccatgatg cccgggtcct gtgacgcaag gcagccctcg gaagtcagca ggacgggacg 2400
gcaagtcaag tacgcccaga gccagaccgt gtttcaaaat ccagacgcac accccgccaa 2460
cagcagcagc gccccgatgc ccgtcctgct gatggggcag gcggtgctcc accccagctt 2520
ccctgcctcc caaccatcgc ccctgcagcc tgcacaggcc cggcagcagc caccgcagca 2580
ctacctgcag gtacaggcac caacctcttt gcacagtgag cagcaggact cgctacttct 2640
ctccacctac tcacaacagc cagggaccct gggctacccc caaccacccc cagcacagcc 2700
ccagccccta cgtcctcccc gaagggtcag cagtctgtct gagtcgtcag gcctccagca 2760
gccgccccga taatgccccg gcactgaagt cgggacacaa tcagctttaa ccaatggatg 2820
aggggggtgg ccacaggaga tggggagagg agtctgaact aaacccctgg cttttgtgca 2880
cactgcatac gtttcagaac tcctggatgg taaccatctc tggagtgcag cgcttgctgc 2940
agtggaaatg atcaggaata ctgaccgtgt ttctcttgcc tccgaggttc ttgggcacac 3000
tctatagcca tactggacag gaaccaggtg ccccgtgtag gcatcgtcgg tcggtttgcc 3060
gtcagagatg gcgcatctcg ctgcatcccc cgagagtaca ccggttgctc tagccacctg 3120
cggcccgccc atctgcgcta gctggccttc acgctcttga tcgtctttcc tttgtattgg 3180
agaaggactg ggtcagagat ctgttggaga gagagaataa agagattatt tttcattatt 3240
tttaaatggt tgtttttgtt ttaatttgca cagctacaca gaggaaataa cttaggcact 3300
ttctgttttt tttaaaaaaa taataaggtc tcatggcttc atttagagac cacagtaaca 3360
acagcagccc accaatcaga gaagctggtt gttattaacc aagctacaga ttcacacttt 3420
ctggcctaaa ccctaatggg atgaggcttt tcaccccagg ccatgctggt ggtgattttt 3480
tagcccctaa ataaaacact ggactatttc ctgtttactt cattgattgc aactacaaag 3540
gtggactcaa agcaaagcac aatcatgcca gccaacattc cagaattctg ctgagaactc 3600
caagtctgtg aggggagagg ttttacaagc cagacaggcc tgggggactg cagtccccaa 3660
ggagaccctg ccacatgctg gccctttgag tgagaatgct gcatctttct acatatcttc 3720
atgagaatac tgagaattgg attttccttt tcaaaatgca ctttgctttt tttgtatgtt 3780
ttgttatgtt gagatgtttc taaagaaaag attttatgta attataagat gaagcgtagt 3840
gaattgtaca gctgttgtaa taatgaccta tttctatata aaataaaatt gtatggctta 3900
tgtgtaaatt attttgtatc tgagatacca gttccttttc ccaaatataa aagtataaaa 3960
gttttcttgt gtttttctgt gagtgaaaat tttgtaataa attaacaaat ttgtacaatt 4020
4020
<210> 248
<211> 2809
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2809)
<223> PDGFA mRNA
<400> 248
acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc 60
ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg 120
cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc 180
cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg 240
cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg 300
ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg 360
gccgggccag gcgtccaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga 420
ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt 480
cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga 540
ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca 600
ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc 660
ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg 720
ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga 780
ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac 840
gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg 900
gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac 960
agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg 1020
gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc 1080
ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg 1140
acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc 1200
tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag 1260
tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg 1320
aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc 1380
gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cgggaaggcc tagggagtca 1440
ggtaaaaaac ggaaaagaaa aaggttaaaa cccacctaaa gcagccaacc agatgtgagg 1500
tgaggatgag ccgcagccct ttcctgggac atggatgtac atggcgtgtt acattcctga 1560
acctactatg tacggtgctt tattgccagt gtgcggtctt tgttctcctc cgtgaaaaac 1620
tgtgtccgag aacactcggg agaacaaaga gacagtgcac atttgtttaa tgtgacatca 1680
aagcaagtat tgtagcactc ggtgaagcag taagaagctt ccttgtcaaa aagagagaga 1740
gagaaagaga gagagaaaac aaaaccacaa atgacaaaaa caaaacggac tcacaaaaat 1800
atctaaactc gatgagatgg agggtcgccc cgtgggatgg aagtgcagag gtctcagcag 1860
actggatttc tgtccgggtg gtcacaggtg cttttttgcc gaggatgcag agcctgcttt 1920
gggaacgact ccagaggggt gctggtgggc tctgcagggg cccgcaggaa gcaggaatgt 1980
cttggaaacc gccacgcgaa ctttagaaac cacacctcct cgctgtagta tttaagccca 2040
tacagaaacc ttcctgagag ccttaagtgg tttttttttt tgtttttgtt ttgttttttt 2100
tttttttgtt tttttttttt tttttttaca ccataaagtg attattaagc tttccttttt 2160
actctttggc tagctttttt tttttttttt tttttttaat tatctcttgg atgacattta 2220
caccgataac acacaggctg ctgtaactgt caggacagtg cgacggtatt tttcctagca 2280
agatgcaaac taatgagatg tattaaaata aacatggtat acctacctat gcatcatttc 2340
ctaaatgttt ctggctttgt gtttctccct taccctgctt tatttgttaa tttaagccat 2400
tttgaaagaa ctatgcgtca accaatcgta cgccgtccct gcggcacctg ccccagagcc 2460
cgtttgtggc tgagtgacaa cttgttcccc gcagtgcaca cctagaatgc tgtgttccca 2520
cgcggcacgt gagatgcatt gccgcttctg tctgtgttgt tggtgtgccc tggtgccgtg 2580
gtggcggtca ctccctctgc tgccagtgtt tggacagaac ccaaattctt tatttttggt 2640
aagatattgt gctttacctg tattaacaga aatgtgtgtg tgtggtttgt ttttttgtaa 2700
aggtgaagtt tgtatgttta cctaatatta cctgttttgt atacctgaga gcctgctatg 2760
ttcttttttt gttgatccaa aattaaaaaa aaaaatacca ccaacaaaa 2809
<210> 249
<211> 3221
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3221)
<223> PLAT mRNA
<400> 249
gaacttcctc cccctgcttt ataaaaacag gcctgcctca gctccctcat ggccctgtcc 60
actgagcatc ctcccgccac acagaaaccc gcccagccgg ggccaccgac cccaccccct 120
gcctggaaac ttaaaggagg ccggagctgt ggggagctca gagctgagat cctacaggag 180
tccagggctg gagagaaaac ctctgcgagg aaagggaagg agcaagccgt gaatttaagg 240
gacgctgtga agcaatcatg gatgcaatga agagagggct ctgctgtgtg ctgctgctgt 300
gtggagcagt cttcgtttcg cccagccagg aaatccatgc ccgattcaga agaggagcca 360
gatcttacca agtgatctgc agagatgaaa aaacgcagat gatataccag caacatcagt 420
catggctgcg ccctgtgctc agaagcaacc gggtggaata ttgctggtgc aacagtggca 480
gggcacagtg ccactcagtg cctgtcaaaa gttgcagcga gccaaggtgt ttcaacgggg 540
gcacctgcca gcaggccctg tacttctcag atttcgtgtg ccagtgcccc gaaggatttg 600
ctgggaagtg ctgtgaaata gataccaggg ccacgtgcta cgaggaccag ggcatcagct 660
acaggggcac gtggagcaca gcggagagtg gcgccgagtg caccaactgg aacagcagcg 720
cgttggccca gaagccctac agcgggcgga ggccagacgc catcaggctg ggcctgggga 780
accacaacta ctgcagaaac ccagatcgag actcaaagcc ctggtgctac gtctttaagg 840
cggggaagta cagctcagag ttctgcagca cccctgcctg ctctgaggga aacagtgact 900
gctactttgg gaatgggtca gcctaccgtg gcacgcacag cctcaccgag tcgggtgcct 960
cctgcctccc gtggaattcc atgatcctga taggcaaggt ttacacagca cagaacccca 1020
gtgcccaggc actgggcctg ggcaaacata attactgccg gaatcctgat ggggatgcca 1080
agccctggtg ccacgtgctg aagaaccgca ggctgacgtg ggagtactgt gatgtgccct 1140
cctgctccac ctgcggcctg agacagtaca gccagcctca gtttcgcatc aaaggagggc 1200
tcttcgccga catcgcctcc cacccctggc aggctgccat ctttgccaag cacaggaggt 1260
cgcccggaga gcggttcctg tgcgggggca tactcatcag ctcctgctgg attctctctg 1320
ccgcccactg cttccaggag aggtttccgc cccaccacct gacggtgatc ttgggcagaa 1380
cataccgggt ggtccctggc gaggaggagc agaaatttga agtcgaaaaa tacattgtcc 1440
ataaggaatt cgatgatgac acttacgaca atgacattgc gctgctgcag ctgaaatcgg 1500
attcgtcccg ctgtgcccag gagagcagcg tggtccgcac tgtgtgcctt cccccggcgg 1560
acctgcagct gccggactgg acggagtgtg agctctccgg ctacggcaag catgaggcct 1620
tgtctccttt ctattcggag cggctgaagg aggctcatgt cagactgtac ccatccagcc 1680
gctgcacatc acaacattta cttaacagaa cagtcaccga caacatgctg tgtgctggag 1740
acactcggag cggcgggccc caggcaaact tgcacgacgc ctgccagggc gattcgggag 1800
gccccctggt gtgtctgaac gatggccgca tgactttggt gggcatcatc agctggggcc 1860
tgggctgtgg acagaaggat gtcccgggtg tgtacaccaa ggttaccaac tacctagact 1920
ggattcgtga caacatgcga ccgtgaccag gaacacccga ctcctcaaaa gcaaatgaga 1980
tcccgcctct tcttcttcag aagacactgc aaaggcgcag tgcttctcta cagacttctc 2040
cagacccacc acaccgcaga agcgggacga gaccctacag gagagggaag agtgcatttt 2100
cccagatact tcccattttg gaagttttca ggacttggtc tgatttcagg atactctgtc 2160
agatgggaag acatgaatgc acactagcct ctccaggaat gcctcctccc tgggcagaaa 2220
gtggccatgc caccctgttt tcagctaaag cccaacctcc tgacctgtca ccgtgagcag 2280
ctttggaaac aggaccacaa aaatgaaagc atgtctcaat agtaaaagat aacaagatct 2340
ttcaggaaag acggattgca ttagaaatag acagtatatt tatagtcaca agagcccagc 2400
agggcctcaa agttggggca ggctggctgg cccgtcatgt tcctcaaaag cacccttgac 2460
gtcaagtctc cttccccttt ccccactccc tggctctcag aaggtattcc ttttgtgtac 2520
agtgtgtaaa gtgtaaatcc tttttcttta taaactttag agtagcatga gagaattgta 2580
tcatttgaac aactaggctt cagcatattt atagcaatcc atgttagttt ttactttctg 2640
ttgccacaac cctgttttat actgtactta ataaattcag atatattttt cacagttttt 2700
ccaaaatcag agtggaatgg ttttgttata gatgctgtat cccactcttt attcatgttc 2760
acattttaaa atcatttgga attctgcttc actcgcttaa catatacaca acacctgtaa 2820
catacaaggc aatgggctag gtgctccaga ccgggaaaag gagggacagg aatgcttggt 2880
ctgatgggct aatatggcat ttagagaagt accaaggtac agtggagccg gtcacaaaag 2940
ggcagacttg tagtagaatt cagttgcaag agggattggg gaatcttaag gaaaaaatag 3000
aatcttaagg aaaaaataac tgggtgagac gtggactgtg gacaggtgtg gaaaaggcac 3060
tctccatgga ggtatgaata tgtagagggc caagagaggg gagtacaggg agaaatgagt 3120
tgagcttgtc tgaagtgaac ttcaggaaga ggaacatagg ctggaattta gattatgggg 3180
gctctgaaca ccaaactgag tttggactta attgacttct g 3221
<210> 250
<211> 2398
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2398)
<223> PLAU mRNA
<400> 250
ctgatataga gcaggcgccg cgggtcgcag cacagtgcgg agaccgcagc cccggagccc 60
gggccagggt ccacctgtcc ccgcagcgcc ggctcgcgcc ctcctgccgc agccaccgag 120
ccgccgtcta gcgccccgac ctcgccacca tgagagccct gctggcgcgc ctgcttctct 180
gcgtcctggt cgtgagcgac tccaaaggca gcaatgaact tcatcaagtt ccatcgaact 240
gtgactgtct aaatggagga acatgtgtgt ccaacaagta cttctccaac attcactggt 300
gcaactgccc aaagaaattc ggagggcagc actgtgaaat agataagtca aaaacctgct 360
atgaggggaa tggtcacttt taccgaggaa aggccagcac tgacaccatg ggccggccct 420
gcctgccctg gaactctgcc actgtccttc agcaaacgta ccatgcccac agatctgatg 480
ctcttcagct gggcctgggg aaacataatt actgcaggaa cccagacaac cggaggcgac 540
cctggtgcta tgtgcaggtg ggcctaaagc cgcttgtcca agagtgcatg gtgcatgact 600
gcgcagatgg aaaaaagccc tcctctcctc cagaagaatt aaaatttcag tgtggccaaa 660
agactctgag gccccgcttt aagattattg ggggagaatt caccaccatc gagaaccagc 720
cctggtttgc ggccatctac aggaggcacc gggggggctc tgtcacctac gtgtgtggag 780
gcagcctcat cagcccttgc tgggtgatca gcgccacaca ctgcttcatt gattacccaa 840
agaaggagga ctacatcgtc tacctgggtc gctcaaggct taactccaac acgcaagggg 900
agatgaagtt tgaggtggaa aacctcatcc tacacaagga ctacagcgct gacacgcttg 960
ctcaccacaa cgacattgcc ttgctgaaga tccgttccaa ggagggcagg tgtgcgcagc 1020
catcccggac tatacagacc atctgcctgc cctcgatgta taacgatccc cagtttggca 1080
caagctgtga gatcactggc tttggaaaag agaattctac cgactatctc tatccggagc 1140
agctgaaaat gactgttgtg aagctgattt cccaccggga gtgtcagcag ccccactact 1200
acggctctga agtcaccacc aaaatgctgt gtgctgctga cccacagtgg aaaacagatt 1260
cctgccaggg agactcaggg ggacccctcg tctgttccct ccaaggccgc atgactttga 1320
ctggaattgt gagctggggc cgtggatgtg ccctgaagga caagccaggc gtctacacga 1380
gagtctcaca cttcttaccc tggatccgca gtcacaccaa ggaagagaat ggcctggccc 1440
tctgagggtc cccagggagg aaacgggcac cacccgcttt cttgctggtt gtcatttttg 1500
cagtagagtc atctccatca gctgtaagaa gagactggga agataggctc tgcacagatg 1560
gatttgcctg tgccacccac cagggcgaac gacaatagct ttaccctcag gcataggcct 1620
gggtgctggc tgcccagacc cctctggcca ggatggaggg gtggtcctga ctcaacatgt 1680
tactgaccag caacttgtct ttttctggac tgaagcctgc aggagttaaa aagggcaggg 1740
catctcctgt gcatgggtga agggagagcc agctcccccg acggtgggca tttgtgaggc 1800
ccatggttga gaaatgaata atttcccaat taggaagtgt aacagctgag gtctcttgag 1860
ggagcttagc caatgtggga gcagcggttt ggggagcaga gacactaacg acttcagggc 1920
agggctctga tattccatga atgtatcagg aaatatatat gtgtgtgtat gtttgcacac 1980
ttgtgtgtgg gctgtgagtg taagtgtgag taagagctgg tgtctgattg ttaagtctaa 2040
atatttcctt aaactgtgtg gactgtgatg ccacacagag tggtctttct ggagaggtta 2100
taggtcactc ctggggcctc ttgggtcccc cacgtgacag tgcctgggaa tgtattattc 2160
tgcagcatga cctgtgacca gcactgtctc agtttcactt tcacatagat gtccctttct 2220
tggccagtta tcccttcctt ttagcctagt tcatccaatc ctcactgggt ggggtgagga 2280
ccactcctgt acactgaata tttatatttc actattttta tttatatttt tgtaatttta 2340
aataaaagtg atcaataaaa tgtgattttt ctgatgacaa aaaaaaaaaa aaaaaaaa 2398
<210> 251
<211> 1368
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1368)
<223> PLAUR mRNA
<400> 251
aggagagaag acgtgcaggg accccgcgca caggagctgc cctcgcgaca tgggtcaccc 60
gccgctgctg ccgctgctgc tgctgctcca cacctgcgtc ccagcctctt ggggcctgcg 120
gtgcatgcag tgtaagacca acggggattg ccgtgtggaa gagtgcgccc tgggacagga 180
cctctgcagg accacgatcg tgcgcttgtg ggaagaagga gaagagctgg agctggtgga 240
gaaaagctgt acccactcag agaagaccaa caggaccctg agctatcgga ctggcttgaa 300
gatcaccagc cttaccgagg ttgtgtgtgg gttagacttg tgcaaccagg gcaactctgg 360
ccgggctgtc acctattccc gaagccgtta cctcgaatgc atttcctgtg gctcatcaga 420
catgagctgt gagaggggcc ggcaccagag cctgcagtgc cgcagccctg aagaacagtg 480
cctggatgtg gtgacccact ggatccagga aggtgaagaa gggcgtccaa aggatgaccg 540
ccacctccgt ggctgtggct accttcccgg ctgcccgggc tccaatggtt tccacaacaa 600
cgacaccttc cacttcctga aatgctgcaa caccaccaaa tgcaacgagg gcccaatcct 660
ggagcttgaa aatctgccgc agaatggccg ccagtgttac agctgcaagg ggaacagcac 720
ccatggatgc tcctctgaag agactttcct cattgactgc cgaggcccca tgaatcaatg 780
tctggtagcc accggcactc acgaaccgaa aaaccaaagc tatatggtaa gaggctgtgc 840
aaccgcctca atgtgccaac atgcccacct gggtgacgcc ttcagcatga accacattga 900
tgtctcctgc tgtactaaaa gtggctgtaa ccacccagac ctggatgtcc agtaccgcag 960
tggggctgct cctcagcctg gccctgccca tctcagcctc accatcaccc tgctaatgac 1020
tgccagactg tggggaggca ctctcctctg gacctaaacc tgaaatcccc ctctctgccc 1080
tggctggatc cgggggaccc ctttgccctt ccctcggctc ccagccctac agacttgctg 1140
tgtgacctca ggccagtgtg ccgacctctc tgggcctcag ttttcccagc tatgaaaaca 1200
gctatctcac aaagttgtgt gaagcagaag agaaaagctg gaggaaggcc gtgggccaat 1260
gggagagctc ttgttattat taatattgtt gccgctgttg tgttgttgtt attaattaat 1320
attcatatta tttattttat acttacataa agattttgta ccagtgga 1368
<210> 252
<211> 3538
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3538)
<223> PLG mRNA
<400> 252
gaatcattaa cttaatttga ctatctggtt tgtggatgcg tttactctca tgtaagtcaa 60
caacatcctg ggattgggac ccactttctg ggcactgctg gccagtccca aaatggaaca 120
taaggaagtg gttcttctac ttcttttatt tctgaaatca ggtcaaggag agcctctgga 180
tgactatgtg aatacccagg gggcttcact gttcagtgtc actaagaagc agctgggagc 240
aggaagtata gaagaatgtg cagcaaaatg tgaggaggac gaagaattca cctgcagggc 300
attccaatat cacagtaaag agcaacaatg tgtgataatg gctgaaaaca ggaagtcctc 360
cataatcatt aggatgagag atgtagtttt atttgaaaag aaagtgtatc tctcagagtg 420
caagactggg aatggaaaga actacagagg gacgatgtcc aaaacaaaaa atggcatcac 480
ctgtcaaaaa tggagttcca cttctcccca cagacctaga ttctcacctg ctacacaccc 540
ctcagaggga ctggaggaga actactgcag gaatccagac aacgatccgc aggggccctg 600
gtgctatact actgatccag aaaagagata tgactactgc gacattcttg agtgtgaaga 660
ggaatgtatg cattgcagtg gagaaaacta tgacggcaaa atttccaaga ccatgtctgg 720
actggaatgc caggcctggg actctcagag cccacacgct catggataca ttccttccaa 780
atttccaaac aagaacctga agaagaatta ctgtcgtaac cccgataggg agctgcggcc 840
ttggtgtttc accaccgacc ccaacaagcg ctgggaactt tgtgacatcc cccgctgcac 900
aacacctcca ccatcttctg gtcccaccta ccagtgtctg aagggaacag gtgaaaacta 960
tcgcgggaat gtggctgtta ccgtgtccgg gcacacctgt cagcactgga gtgcacagac 1020
ccctcacaca cataacagga caccagaaaa cttcccctgc aaaaatttgg atgaaaacta 1080
ctgccgcaat cctgacggaa aaagggcccc atggtgccat acaaccaaca gccaagtgcg 1140
gtgggagtac tgtaagatac cgtcctgtga ctcctcccca gtatccacgg aacaattggc 1200
tcccacagca ccacctgagc taacccctgt ggtccaggac tgctaccatg gtgatggaca 1260
gagctaccga ggcacatcct ccaccaccac cacaggaaag aagtgtcagt cttggtcatc 1320
tatgacacca caccggcacc agaagacccc agaaaactac ccaaatgctg gcctgacaat 1380
gaactactgc aggaatccag atgccgataa aggcccctgg tgttttacca cagaccccag 1440
cgtcaggtgg gagtactgca acctgaaaaa atgctcagga acagaagcga gtgttgtagc 1500
acctccgcct gttgtcctgc ttccagatgt agagactcct tccgaagaag actgtatgtt 1560
tgggaatggg aaaggatacc gaggcaagag ggcgaccact gttactggga cgccatgcca 1620
ggactgggct gcccaggagc cccatagaca cagcattttc actccagaga caaatccacg 1680
ggcgggtctg gaaaaaaatt actgccgtaa ccctgatggt gatgtaggtg gtccctggtg 1740
ctacacgaca aatccaagaa aactttacga ctactgtgat gtccctcagt gtgcggcccc 1800
ttcatttgat tgtgggaagc ctcaagtgga gccgaagaaa tgtcctggaa gggttgtagg 1860
ggggtgtgtg gcccacccac attcctggcc ctggcaagtc agtcttagaa caaggtttgg 1920
aatgcacttc tgtggaggca ccttgatatc cccagagtgg gtgttgactg ctgcccactg 1980
cttggagaag tccccaaggc cttcatccta caaggtcatc ctgggtgcac accaagaagt 2040
gaatctcgaa ccgcatgttc aggaaataga agtgtctagg ctgttcttgg agcccacacg 2100
aaaagatatt gccttgctaa agctaagcag tcctgccgtc atcactgaca aagtaatccc 2160
agcttgtctg ccatccccaa attatgtggt cgctgaccgg accgaatgtt tcatcactgg 2220
ctggggagaa acccaaggta cttttggagc tggccttctc aaggaagccc agctccctgt 2280
gattgagaat aaagtgtgca atcgctatga gtttctgaat ggaagagtcc aatccaccga 2340
actctgtgct gggcatttgg ccggaggcac tgacagttgc cagggtgaca gtggaggtcc 2400
tctggtttgc ttcgagaagg acaaatacat tttacaagga gtcacttctt ggggtcttgg 2460
ctgtgcacgc cccaataagc ctggtgtcta tgttcgtgtt tcaaggtttg ttacttggat 2520
tgagggagtg atgagaaata attaattgga cgggagacag agtgacgcac tgactcacct 2580
agaggctgga acgtgggtag ggatttagca tgctggaaat aactggcagt aatcaaacga 2640
agacactgtc cccagctacc agctacgcca aacctcggca ttttttgtgt tattttctga 2700
ctgctggatt ctgtagtaag gtgacatagc tatgacattt gttaaaaata aactctgtac 2760
ttaactttga tttgagtaaa ttttggtttt ggtcttcaac attttcatgc tctttgttca 2820
ccccaccaat ttttaaatgg gcagatgggg ggatttagct gcttttgata aggaacagct 2880
gcacaaagga ctgagcaggc tgcaaggtca cagaggggag agccaagaag ttgtccacgc 2940
atttacctca tcagctaacg agggcttgac atgcattttt actgtcttta ttcctgacac 3000
tgagatgaat gttttcaaag ctgcaacatg tatggggagt catgcaaacc gattctgtta 3060
ttgggaatga aatctgtcac cgactgcttg acttgagccc aggggacacg gagcagagag 3120
ctgtatatga tggagtgaac cggtccatgg atgtgtaaca caagaccaac tgagagtctg 3180
aatgttattc tggggcacac gtgagtctag gattggtgcc aagagcatgt aaatgaacaa 3240
caagcaaata ttgaaggtgg accacttatt tcccattgct aattgcctgc ccggttttga 3300
aacagtctgc agtacacacg gtcacaggag aatgacctgt gggagagata catgtttaga 3360
aggaagagaa aggacaaagg cacacgtttt accatttaaa atattgttac caaacaaaaa 3420
tatccattca aaatacaatt taacaatgca acagtcatct tacagcagag aaatgcagag 3480
aaaagcaaaa ctgcaagtga ctgtgaataa agggtgaatg tagtctcaaa tcctcaaa 3538
<210> 253
<211> 8718
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(8718)
<223> PTEN mRNA
<400> 253
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60
ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 120
gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 180
gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 240
tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 300
gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 360
gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 420
cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 480
aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg 540
cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca 600
gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc 660
ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac 720
cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt 780
cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc 840
agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc 900
aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc 960
agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca 1020
ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc 1080
aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat 1140
ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt 1200
tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg 1260
acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac 1320
agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca 1380
atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg 1440
catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg 1500
aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt 1560
attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca 1620
agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg 1680
tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca 1740
agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt 1800
tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata 1860
cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg 1920
atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag 1980
tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact 2040
tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc 2100
cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt 2160
atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc 2220
atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa 2280
taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc 2340
agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat 2400
ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat 2460
ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt 2520
tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt 2580
ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt 2640
cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt 2700
tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc 2760
tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca 2820
cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt 2880
cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa 2940
aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca 3000
aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat 3060
ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat 3120
ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag 3180
tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta 3240
gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc 3300
tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag 3360
taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc 3420
acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa 3480
tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa 3540
aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa 3600
aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat 3660
tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat 3720
catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa 3780
aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta 3840
ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct 3900
tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata 3960
aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta 4020
gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg 4080
gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt 4140
tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt 4200
acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt 4260
ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc 4320
tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag 4380
ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg 4440
ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca 4500
ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt 4560
tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat 4620
ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca 4680
gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa 4740
ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct 4800
ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag 4860
ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc 4920
tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca 4980
tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa 5040
atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt 5100
tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa 5160
tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc 5220
tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt 5280
ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca 5340
gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg 5400
aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt 5460
ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa 5520
aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa 5580
ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag 5640
ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa 5700
aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact 5760
tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta 5820
gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt 5880
gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta 5940
ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc 6000
atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg 6060
ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt 6120
aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca 6180
gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa 6240
aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat 6300
cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga 6360
agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc 6420
tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag 6480
aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag 6540
acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc 6600
agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta 6660
gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa 6720
ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag 6780
atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa 6840
tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt 6900
ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac 6960
aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa 7020
tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc 7080
atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt 7140
aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa 7200
atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt 7260
tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca 7320
gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg 7380
tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata 7440
gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga 7500
attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc 7560
cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa 7620
ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa 7680
atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct 7740
gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata 7800
gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca 7860
atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac 7920
tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt 7980
ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt 8040
gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc 8100
tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg 8160
gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc 8220
ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta 8280
ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg 8340
tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt 8400
aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa 8460
tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt 8520
agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt 8580
tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa 8640
atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact 8700
aaaaaaaaaa aaaaaaaa 8718
<210> 254
<211> 4510
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4510)
<223> PTGS2 mRNA
<400> 254
aattgtcata cgacttgcag tgagcgtcag gagcacgtcc aggaactcct cagcagcgcc 60
tccttcagct ccacagccag acgccctcag acagcaaagc ctacccccgc gccgcgccct 120
gcccgccgct gcgatgctcg cccgcgccct gctgctgtgc gcggtcctgg cgctcagcca 180
tacagcaaat ccttgctgtt cccacccatg tcaaaaccga ggtgtatgta tgagtgtggg 240
atttgaccag tataagtgcg attgtacccg gacaggattc tatggagaaa actgctcaac 300
accggaattt ttgacaagaa taaaattatt tctgaaaccc actccaaaca cagtgcacta 360
catacttacc cacttcaagg gattttggaa cgttgtgaat aacattccct tccttcgaaa 420
tgcaattatg agttatgtgt tgacatccag atcacatttg attgacagtc caccaactta 480
caatgctgac tatggctaca aaagctggga agccttctct aacctctcct attatactag 540
agcccttcct cctgtgcctg atgattgccc gactcccttg ggtgtcaaag gtaaaaagca 600
gcttcctgat tcaaatgaga ttgtggaaaa attgcttcta agaagaaagt tcatccctga 660
tccccagggc tcaaacatga tgtttgcatt ctttgcccag cacttcacgc atcagttttt 720
caagacagat cataagcgag ggccagcttt caccaacggg ctgggccatg gggtggactt 780
aaatcatatt tacggtgaaa ctctggctag acagcgtaaa ctgcgccttt tcaaggatgg 840
aaaaatgaaa tatcagataa ttgatggaga gatgtatcct cccacagtca aagatactca 900
ggcagagatg atctaccctc ctcaagtccc tgagcatcta cggtttgctg tggggcagga 960
ggtctttggt ctggtgcctg gtctgatgat gtatgccaca atctggctgc gggaacacaa 1020
cagagtatgc gatgtgctta aacaggagca tcctgaatgg ggtgatgagc agttgttcca 1080
gacaagcagg ctaatactga taggagagac tattaagatt gtgattgaag attatgtgca 1140
acacttgagt ggctatcact tcaaactgaa atttgaccca gaactacttt tcaacaaaca 1200
attccagtac caaaatcgta ttgctgctga atttaacacc ctctatcact ggcatcccct 1260
tctgcctgac acctttcaaa ttcatgacca gaaatacaac tatcaacagt ttatctacaa 1320
caactctata ttgctggaac atggaattac ccagtttgtt gaatcattca ccaggcaaat 1380
tgctggcagg gttgctggtg gtaggaatgt tccacccgca gtacagaaag tatcacaggc 1440
ttccattgac cagagcaggc agatgaaata ccagtctttt aatgagtacc gcaaacgctt 1500
tatgctgaag ccctatgaat catttgaaga acttacagga gaaaaggaaa tgtctgcaga 1560
gttggaagca ctctatggtg acatcgatgc tgtggagctg tatcctgccc ttctggtaga 1620
aaagcctcgg ccagatgcca tctttggtga aaccatggta gaagttggag caccattctc 1680
cttgaaagga cttatgggta atgttatatg ttctcctgcc tactggaagc caagcacttt 1740
tggtggagaa gtgggttttc aaatcatcaa cactgcctca attcagtctc tcatctgcaa 1800
taacgtgaag ggctgtccct ttacttcatt cagtgttcca gatccagagc tcattaaaac 1860
agtcaccatc aatgcaagtt cttcccgctc cggactagat gatatcaatc ccacagtact 1920
actaaaagaa cgttcgactg aactgtagaa gtctaatgat catatttatt tatttatatg 1980
aaccatgtct attaatttaa ttatttaata atatttatat taaactcctt atgttactta 2040
acatcttctg taacagaagt cagtactcct gttgcggaga aaggagtcat acttgtgaag 2100
acttttatgt cactactcta aagattttgc tgttgctgtt aagtttggaa aacagttttt 2160
attctgtttt ataaaccaga gagaaatgag ttttgacgtc tttttacttg aatttcaact 2220
tatattataa gaacgaaagt aaagatgttt gaatacttaa acactgtcac aagatggcaa 2280
aatgctgaaa gtttttacac tgtcgatgtt tccaatgcat cttccatgat gcattagaag 2340
taactaatgt ttgaaatttt aaagtacttt tggttatttt tctgtcatca aacaaaaaca 2400
ggtatcagtg cattattaaa tgaatattta aattagacat taccagtaat ttcatgtcta 2460
ctttttaaaa tcagcaatga aacaataatt tgaaatttct aaattcatag ggtagaatca 2520
cctgtaaaag cttgtttgat ttcttaaagt tattaaactt gtacatatac caaaaagaag 2580
ctgtcttgga tttaaatctg taaaatcagt agaaatttta ctacaattgc ttgttaaaat 2640
attttataag tgatgttcct ttttcaccaa gagtataaac ctttttagtg tgactgttaa 2700
aacttccttt taaatcaaaa tgccaaattt attaaggtgg tggagccact gcagtgttat 2760
cttaaaataa gaatattttg ttgagatatt ccagaatttg tttatatggc tggtaacatg 2820
taaaatctat atcagcaaaa gggtctacct ttaaaataag caataacaaa gaagaaaacc 2880
aaattattgt tcaaatttag gtttaaactt ttgaagcaaa ctttttttta tccttgtgca 2940
ctgcaggcct ggtactcaga ttttgctatg aggttaatga agtaccaagc tgtgcttgaa 3000
taatgatatg ttttctcaga ttttctgttg tacagtttaa tttagcagtc catatcacat 3060
tgcaaaagta gcaatgacct cataaaatac ctcttcaaaa tgcttaaatt catttcacac 3120
attaatttta tctcagtctt gaagccaatt cagtaggtgc attggaatca agcctggcta 3180
cctgcatgct gttccttttc ttttcttctt ttagccattt tgctaagaga cacagtcttc 3240
tcatcacttc gtttctccta ttttgtttta ctagttttaa gatcagagtt cactttcttt 3300
ggactctgcc tatattttct tacctgaact tttgcaagtt ttcaggtaaa cctcagctca 3360
ggactgctat ttagctcctc ttaagaagat taaaagagaa aaaaaaaggc ccttttaaaa 3420
atagtataca cttattttaa gtgaaaagca gagaatttta tttatagcta attttagcta 3480
tctgtaacca agatggatgc aaagaggcta gtgcctcaga gagaactgta cggggtttgt 3540
gactggaaaa agttacgttc ccattctaat taatgccctt tcttatttaa aaacaaaacc 3600
aaatgatatc taagtagttc tcagcaataa taataatgac gataatactt cttttccaca 3660
tctcattgtc actgacattt aatggtactg tatattactt aatttattga agattattat 3720
ttatgtctta ttaggacact atggttataa actgtgttta agcctacaat cattgatttt 3780
tttttgttat gtcacaatca gtatattttc tttggggtta cctctctgaa tattatgtaa 3840
acaatccaaa gaaatgattg tattaagatt tgtgaataaa tttttagaaa tctgattggc 3900
atattgagat atttaaggtt gaatgtttgt ccttaggata ggcctatgtg ctagcccaca 3960
aagaatattg tctcattagc ctgaatgtgc cataagactg accttttaaa atgttttgag 4020
ggatctgtgg atgcttcgtt aatttgttca gccacaattt attgagaaaa tattctgtgt 4080
caagcactgt gggttttaat atttttaaat caaacgctga ttacagataa tagtatttat 4140
ataaataatt gaaaaaaatt ttcttttggg aagagggaga aaatgaaata aatatcatta 4200
aagataactc aggagaatct tctttacaat tttacgttta gaatgtttaa ggttaagaaa 4260
gaaatagtca atatgcttgt ataaaacact gttcactgtt ttttttaaaa aaaaaacttg 4320
atttgttatt aacattgatc tgctgacaaa acctgggaat ttgggttgtg tatgcgaatg 4380
tttcagtgcc tcagacaaat gtgtatttaa cttatgtaaa agataagtct ggaaataaat 4440
gtctgtttat ttttgtacta tttaaaaatt gacagatctt ttctgaagat aaactttgat 4500
tgtttctata 4510
<210> 255
<211> 1884
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1884)
<223> PTX3 mRNA
<400> 255
actctcactc tcctccgctc aaactcagct cacttgagag tctcctcccg ccagctgtgg 60
aaagaacttt gcgtctctcc agcaatgcat ctccttgcga ttctgttttg tgctctctgg 120
tctgcagtgt tggccgagaa ctcggatgat tatgatctca tgtatgtgaa tttggacaac 180
gaaatagaca atggactcca tcccactgag gaccccacgc cgtgcgcctg cggtcaggag 240
cactcggaat gggacaagct cttcatcatg ctggagaact cgcagatgag agagcgcatg 300
ctgctgcaag ccacggacga cgtcctgcgg ggcgagctgc agaggctgcg ggaggagctg 360
ggccggctcg cggaaagcct ggcgaggccg tgcgcgccgg gggctcccgc agaggccagg 420
ctgaccagtg ctctggacga gctgctgcag gcgacccgcg acgcgggccg caggctggcg 480
cgtatggagg gcgcggaggc gcagcgccca gaggaggcgg ggcgcgccct ggccgcggtg 540
ctagaggagc tgcggcagac gcgagccgac ctgcacgcgg tgcagggctg ggctgcccgg 600
agctggctgc cggcaggttg tgaaacagct attttattcc caatgcgttc caagaagatt 660
tttggaagcg tgcatccagt gagaccaatg aggcttgagt cttttagtgc ctgcatttgg 720
gtcaaagcca cagatgtatt aaacaaaacc atcctgtttt cctatggcac aaagaggaat 780
ccatatgaaa tccagctgta tctcagctac caatccatag tgtttgtggt gggtggagag 840
gagaacaaac tggttgctga agccatggtt tccctgggaa ggtggaccca cctgtgcggc 900
acctggaatt cagaggaagg gctcacatcc ttgtgggtaa atggtgaact ggcggctacc 960
actgttgaga tggccacagg tcacattgtt cctgagggag gaatcctgca gattggccaa 1020
gaaaagaatg gctgctgtgt gggtggtggc tttgatgaaa cattagcctt ctctgggaga 1080
ctcacaggct tcaatatctg ggatagtgtt cttagcaatg aagagataag agagaccgga 1140
ggagcagagt cttgtcacat ccgggggaat attgttgggt ggggagtcac agagatccag 1200
ccacatggag gagctcagta tgtttcataa atgttgtgaa actccacttg aagccaaaga 1260
aagaaactca cacttaaaac acatgccagt tgggaaggtc tgaaaactca gtgcataata 1320
ggaacacttg agactaatga aagagagagt tgagaccaat ctttatttgt actggccaaa 1380
tactgaataa acagttgaag gaaagacatt ggaaaaagct tttgaggata atgttactag 1440
actttatgcc atggtgcttt cagtttaatg ctgtgtctct gtcagataaa ctctcaaata 1500
attaaaaagg actgtattgt tgaacagagg gacaattgtt ttacttttct ttggttaatt 1560
ttgttttggc cagagatgaa ttttacattg gaagaataac aaaataagat ttgttgtcca 1620
ttgttcattg ttattggtat gtaccttatt acaaaaaaaa gatgaaaaca tatttatact 1680
acaaggtgac ttaacaacta taaatgtagt ttatgtgtta taatcgaatg tcacgttttt 1740
gagaagatag tcatataagt tatattgcaa aagggatttg tattaattta agactatttt 1800
tgtaaagctc tactgtaaat aaaatatttt ataaaactag ctcacgtcat ttaattataa 1860
atttaagaga tgttttggag caaa 1884
<210> 256
<211> 2398
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2398)
<223> RAC1 mRNA
<400> 256
gggaggccgg atgtgagtgg agcggccatt tcctgtttct ctgcagtttt cctcagcttt 60
gggtggtggc cgctgccggg catcggcttc cagtccgcgg agggcgaggc ggcgtggaca 120
gcggccccgg cacccagcgc cccgccgccc gcaagccgcg cgcccgtccg ccgcgccccg 180
agcccgccgc ttcctatctc agcgccctgc cgccgccgcc gcggcccagc gagcggccct 240
gatgcaggcc atcaagtgtg tggtggtggg agacggagct gtaggtaaaa cttgcctact 300
gatcagttac acaaccaatg catttcctgg agaatatatc cctactgtct ttgacaatta 360
ttctgccaat gttatggtag atggaaaacc ggtgaatctg ggcttatggg atacagctgg 420
acaagaagat tatgacagat tacgccccct atcctatccg caaacagttg gagaaacgta 480
cggtaaggat ataacctccc ggggcaaaga caagccgatt gccgatgtgt tcttaatttg 540
cttttccctt gtgagtcctg catcatttga aaatgtccgt gcaaagtggt atcctgaggt 600
gcggcaccac tgtcccaaca ctcccatcat cctagtggga actaaacttg atcttaggga 660
tgataaagac acgatcgaga aactgaagga gaagaagctg actcccatca cctatccgca 720
gggtctagcc atggctaagg agattggtgc tgtaaaatac ctggagtgct cggcgctcac 780
acagcgaggc ctcaagacag tgtttgacga agcgatccga gcagtcctct gcccgcctcc 840
cgtgaagaag aggaagagaa aatgcctgct gttgtaaatg tctcagcccc tcgttcttgg 900
tcctgtccct tggaaccttt gtacgctttg ctcaaaaaaa aacaaaaaaa aaaaacaaaa 960
aaaaaaaaca acggtggagc cttcgcactc aatgccaact ttttgttaca gattaatttt 1020
tccataaaac cattttttga accaatcagt aattttaagg ttttgtttgt tctaaatgta 1080
agagttcaga ctcacattct attaaaattt agccctaaaa tgacaagcct tcttaaagcc 1140
ttatttttca aaagcgcccc ccccattctt gttcagatta agagttgcca aaataccttc 1200
tgaactacac tgcattgttg tgccgagaac accgagcact gaactttgca aagaccttcg 1260
tctttgagaa gacggtagct tctgcagtta ggaggtgcag acacttgctc tcctatgtag 1320
ttctcagatg cgtaaagcag aacagcctcc cgaatgaagc gttgccattg aactcaccag 1380
tgagttagca gcacgtgttc ccgacataac attgtactgt aatggagtga gcgtagcagc 1440
tcagctcttt ggatcagtct ttgtgatttc atagcgagtt ttctgaccag cttttgcgga 1500
gattttgaac agaactgcta tttcctctaa tgaagaattc tgtttagctg tgggtgtgcc 1560
gggtggggtg tgtgtgatca aaggacaaag acagtatttt gacaaaatac gaagtggaga 1620
tttacactac attgtacaag gaatgaaagt gtcacgggta aaaactctaa aaggttaatt 1680
tctgtcaaat gcagtagatg atgaaagaaa ggttggtatt atcaggaaat gttttcttaa 1740
gcttttcctt tctcttacac ctgccatgcc tccccaaatt gggcatttaa ttcatcttta 1800
aactggttgt tctgttagtc gctaacttag taagtgcttt tcttatagaa ccccttctga 1860
ctgagcaata tgcctccttg tattataaaa tctttctgat aatgcattag aaggtttttt 1920
tgtcgattag taaaagtgct ttccatgtta ctttattcag agctaataag tgctttcctt 1980
agttttctag taactaggtg taaaaatcat gtgttgcagc tttatagttt ttaaaatatt 2040
ttagataatt cttaaactat gaaccttctt aacatcactg tcttgccaga ttaccgacac 2100
tgtcacttga ccaatactga ccctctttac ctcgcccacg cggacacacg cctcctgtag 2160
tcgctttgcc tattgatgtt cctttgggtc tgtgaggttc tgtaaactgt gctagtgctg 2220
acgatgttct gtacaactta actcactggc gagaatacag cgtgggaccc ttcagccact 2280
acaacagaat tttttaaatt gacagttgca gaattgtgga gtgtttttac attgatcttt 2340
tgctaatgca attagcatta tgttttgcat gtatgactta ataaatcctt gaatcata 2398
<210> 257
<211> 1943
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1943)
<223> RHOA mRNA
<400> 257
aatagtggat gagctgtgag tgcgcgcgcg tgcgcggggc cgcgacctgt gccggctcga 60
gcccgctggg cactcggagg cgcgcacgtc gttccccgcc ctcccgccgc cgcccgccct 120
cgctctctcg cgctaccctc ccgccgcccg cggtcctccg tcggttctct cgttagtcca 180
cggtctggtc ttcagctacc cgccttcgtc tccgagtttg cgactcgcgg accggcgtcc 240
ccggcgcgaa gaggctggac tcggattcgt tgcctgagca atggctgcca tccggaagaa 300
actggtgatt gttggtgatg gagcctgtgg aaagacatgc ttgctcatag tcttcagcaa 360
ggaccagttc ccagaggtgt atgtgcccac agtgtttgag aactatgtgg cagatatcga 420
ggtggatgga aagcaggtag agttggcttt gtgggacaca gctgggcagg aagattatga 480
tcgcctgagg cccctctcct acccagatac cgatgttata ctgatgtgtt tttccatcga 540
cagccctgat agtttagaaa acatcccaga aaagtggacc ccagaagtca agcatttctg 600
tcccaacgtg cccatcatcc tggttgggaa taagaaggat cttcggaatg atgagcacac 660
aaggcgggag ctagccaaga tgaagcagga gccggtgaaa cctgaagaag gcagagatat 720
ggcaaacagg attggcgctt ttgggtacat ggagtgttca gcaaagacca aagatggagt 780
gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa gctagacgtg ggaagaaaaa 840
atctgggtgc cttgtcttgt gaaaccttgc tgcaagcaca gcccttatgc ggttaatttt 900
gaagtgctgt ttattaatct tagtgtatga ttactggcct ttttcattta tctataattt 960
acctaagatt acaaatcaga agtcatcttg ctaccagtat ttagaagcca actatgatta 1020
ttaacgatgt ccaacccgtc tggcccacca gggtcctttt gacactgctc taacagccct 1080
cctctgcact cccacctgac acaccaggcg ctaattcaag gaatttctta acttcttgct 1140
tctttctaga aagagaaaca gttggtaact tttgtgaatt aggctgtaac tactttataa 1200
ctaacatgtc ctgcctatta tctgtcagct gcaaggtact ctggtgagtc accacttcag 1260
ggctttactc cgtaacagat tttgttggca tagctctggg gtgggcagtt ttttgaaaat 1320
gggctcaacc agaaaagccc aagttcatgc agctgtggca gagttacagt tctgtggttt 1380
catgttagtt accttatagt tactgtgtaa ttagtgccac ttaatgtatg ttaccaaaaa 1440
taaatatatc taccccagac tagatgtagt attttttgta taattggatt tcctaatact 1500
gtcatcctca aagaaagtgt attggttttt taaaaaagaa agtgtatttg gaaataaagt 1560
cagatggaaa attcattttt taaattcccg ttttgtcact ttttctgata aaagatggcc 1620
atattacccc ttttcggccc catgtatctc agtaccccat ggagctgggc taagtaaata 1680
ggaattggtt tcacgcctga ggcaattaga cactttggaa gatggcataa cctgtctcac 1740
ctggacttaa gcatctggct ctaattcaca gtgctctttt ctcctcactg tatccaggtt 1800
ccctcccaga ggagccacca gttctcatgg gtggcactca gtctctcttc tctccagctg 1860
actaaacttt ttttctgtac cagttaattt ttccaactac taatagaata aaggcagttt 1920
tctaaacttc ctgtaaaaaa aaa 1943
<210> 258
<211> 3207
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3207)
<223> SERPINB2 mRNA
<400> 258
ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc 60
cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac 120
gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac 180
ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc 240
atcctacgtg gcccacctgg cctcagactt cggggtgagg gtgtttcagc aggtggcgca 300
ggcctccaag gaccgcaacg tggttttctc accctatggg gtggcctcgg tgttggccat 360
gctccagctg acaacaggag gagaaaccca gcagcagatt caagcagcta tgggattcaa 420
gattgatgac aagggcatgg cccccgccct ccggcatctg tacaaggagc tcatggggcc 480
atggaacaag gatgagatca gcaccacaga cgcgatcttc gtccagcggg atctgaagct 540
ggtccagggc ttcatgcccc acttcttcag gctgttccgg agcacggtca agcaagtgga 600
cttttcagag gtggagagag ccagattcat catcaatgac tgggtgaaga cacacacaaa 660
aggtatgatc agcaacttgc ttgggaaagg agccgtggac cagctgacac ggctggtgct 720
ggtgaatgcc ctctacttca acggccagtg gaagactccc ttccccgact ccagcaccca 780
ccgccgcctc ttccacaaat cagacggcag cactgtctct gtgcccatga tggctcagac 840
caacaagttc aactatactg agttcaccac gcccgatggc cattactacg acatcctgga 900
actgccctac cacggggaca ccctcagcat gttcattgct gccccttatg aaaaagaggt 960
gcctctctct gccctcacca acattctgag tgcccagctc atcagccact ggaaaggcaa 1020
catgaccagg ctgccccgcc tcctggttct gcccaagttc tccctggaga ctgaagtcga 1080
cctcaggaag cccctagaga acctgggaat gaccgacatg ttcagacagt ttcaggctga 1140
cttcacgagt ctttcagacc aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa 1200
gatcgaggtg aacgagagtg gcacggtggc ctcctcatcc acagctgtca tagtctcagc 1260
ccgcatggcc cccgaggaga tcatcatgga cagacccttc ctctttgtgg tccggcacaa 1320
ccccacagga acagtccttt tcatgggcca agtgatggaa ccctgaccct ggggaaagac 1380
gccttcatct gggacaaaac tggagatgca tcgggaaaga agaaactccg aagaaaagaa 1440
ttttagtgtt aatgactctt tctgaaggaa gagaagacat ttgccttttg ttaaaagatg 1500
gtaaaccaga tctgtctcca agaccttggc ctctccttgg aggaccttta ggtcaaactc 1560
cctagtctcc acctgagacc ctgggagaga agtttgaagc acaactccct taaggtctcc 1620
aaaccagacg gtgacgcctg cgggaccatc tggggcacct gcttccaccc gtctctctgc 1680
ccactcgggt ctgcagacct ggttcccact gaggcccttt gcaggatgga actacggggc 1740
ttacaggagc ttttgtgtgc ctggtagaaa ctatttctgt tccagtcaca ttgccatcac 1800
tcttgtactg cctgccaccg cggaggaggc tggtgacagg ccaaaggcca gtggaagaaa 1860
caccctttca tctcagagtc cactgtggca ctggccaccc ctccccagta caggggtgct 1920
gcaggtggca gagtgaatgt cccccatcat gtggcccaac tctcctggcc tggccatctc 1980
cctccccaga aacagtgtgc atgggttatt ttggagtgta ggtgacttgt ttactcattg 2040
aagcagattt ctgcttcctt ttatttttat aggaatagag gaagaaatgt cagatgcgtg 2100
cccagctctt caccccccaa tctcttggtg gggaggggtg tacctaaata tttatcatat 2160
ccttgccctt gagtgcttgt tagagagaaa gagaactact aaggaaaata atattattta 2220
aactcgctcc tagtgtttct ttgtggtctg tgtcaccgta tctcaggaag tccagccact 2280
tgactggcac acacccctcc ggacatccag cgtgacggag cccacactgc caccttgtgg 2340
ccgcctgaga ccctcgcgcc ccccgcgccc ctctttttcc ccttgatgga aattgaccat 2400
acaatttcat cctccttcag gggatcaaaa ggacggagtg gggggacaga gactcagatg 2460
aggacagagt ggtttccaat gtgttcaata gatttaggag cagaaatgca aggggctgca 2520
tgacctacca ggacagaact ttccccaatt acagggtgac tcacagccgc attggtgact 2580
cacttcaatg tgtcatttcc ggctgctgtg tgtgagcagt ggacacgtga ggggggggtg 2640
ggtgagagag acaggcagct cggattcaac taccttagat aatatttctg aaaacctacc 2700
agccagaggg tagggcacaa agatggatgt aatgcacttt gggaggccaa ggcgggagga 2760
ttgcttgagc ccaggagttc aagaccagcc tgggcaacat accaagaccc ccgtctcttt 2820
aaaaatatat atattttaaa tatacttaaa tatatatttc taatatcttt aaatatatat 2880
atatatttta aagaccaatt tatgggagaa ttgcacacag atgtgaaatg aatgtaatct 2940
aatagaagcc taatcagccc accatgttct ccactgaaaa atcctctttc tttggggttt 3000
ttctttcttt cttttttgat tttgcactgg acggtgacgt cagccatgta caggatccac 3060
aggggtggtg tcaaatgcta ttgaaattgt gttgaattgt atgctttttc acttttgata 3120
aataaacatg taaaaatgtt tcaaaaaaat aataaaataa ataaatacga agaatatgtc 3180
aggacagtca aaaaaaaaaa aaaaaaa 3207
<210> 259
<211> 2180
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2180)
<223> SERPINE1 mRNA
<400> 259
gtaacaactc tcagaggagc attgcccgtc agacagcaac tcagagaata accagagaac 60
aaccagcatt tcttgcacta caacttgctt aagctcttac acttcatagt gaagctatgc 120
accaccgagt gaagcgatgt ggaacattgg aaagagtggg cttccttaga cagacctggg 180
cttgaatccc tgctccacta cctaccagct gtgtgacctt atacaagtta cttaatgttt 240
ctgagcatca ggatataatc tataaaatag ggagaatcac ctctacctca tacagattct 300
gcaaagatta aacgaggaga ggagattgaa acaatggagg atctttgtgt ggcaaacaca 360
ctctttgccc tcaatttatt caagcatctg gcaaaagcaa gccccaccca gaacctcttc 420
ctctccccat ggagcatctc gtccaccatg gccatggtct acatgggctc caggggcagc 480
accgaagacc agatggccaa ggtgcttcag tttaatgaag tgggagccaa tgcagttacc 540
cccatgactc cagagaactt taccagctgt gggttcatgc agcagatcca gaagggtagt 600
tatcctgatg cgattttgca ggcacaagct gcagataaaa tccattcatc cttccgctct 660
ctcagctctg caatcaatgc atccacaggg aattatttac tggaaagtgt caataagctg 720
tttggtgaga agtctgcgag cttccgggaa gaatatattc gactctgtca gaaatattac 780
tcctcagaac cccaggcagt agacttccta gaatgtgcag aagaagctag aaaaaagatt 840
aattcctggg tcaagactca aaccaaaggc aaaatcccaa acttgttacc tgaaggttct 900
gtagatgggg ataccaggat ggtcctggtg aatgctgtct acttcaaagg aaagtggaaa 960
actccatttg agaagaaact aaatgggctt tatcctttcc gtgtaaactc ggctcagcgc 1020
acacctgtac agatgatgta cttgcgtgaa aagctaaaca ttggatacat agaagaccta 1080
aaggctcaga ttctagaact cccatatgct ggagatgtta gcatgttctt gttgcttcca 1140
gatgaaattg ccgatgtgtc cactggcttg gagctgctgg aaagtgaaat aacctatgac 1200
aaactcaaca agtggaccag caaagacaaa atggctgaag atgaagttga ggtatacata 1260
ccccagttca aattagaaga gcattatgaa ctcagatcca ttctgagaag catgggcatg 1320
gaggacgcct tcaacaaggg acgggccaat ttctcaggga tgtcggagag gaatgacctg 1380
tttctttctg aagtgttcca ccaagccatg gtggatgtga atgaggaggg cactgaagca 1440
gccgctggca caggaggtgt tatgacaggg agaactggac atggaggccc acagtttgtg 1500
gcagatcatc cttttctttt tcttattatg cataagataa ccaactgcat tttatttttc 1560
ggcagatttt cctcacccta aaactaagcg tgctgcttct gcaaaagatt tttgtagatg 1620
agctgtgtgc ctcagaattg ctatttcaaa ttgccaaaaa tttagagatg ttttctacat 1680
atttctgctc ttctgaacaa cttctgctac ccactaaata aaaacacaga aataattaga 1740
caattgtcta ttataacatg acaaccctat taatcatttg gtcttctaaa atgggatcat 1800
gcccatttag attttcctta ctatcagttt atttttataa cattaacttt tactttgtta 1860
tttattattt tatataatgg tgagttttta aattattgct cactgcctat ttaatgtagc 1920
taataaagtt atagaagcag atgatctgtt aatttcctat ctaataaatg cctttaattg 1980
ttctcataat gaagaataag taggtatccc tccatgccct tctgtaataa atatctggaa 2040
aaaacattaa acaataggca aatatatgtt atgtgcattt ctagaaatac ataacacata 2100
tatatgtctg tatcttatat tcaattgcaa gtatataata aataaacctg cttccaaaca 2160
acaataaaaa aaaaaaaaaa 2180
<210> 260
<211> 2259
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2259)
<223> SERPINE2 mRNA
<400> 260
cgataaagcc cccgccgccg cggcagccag cttgcgctgt ggggctgccc gggctgcgcg 60
gcgtctgcag gcgccaccgc tgcctctttc cggctgtgac cctcctcgcc gccgccgctt 120
ggctgcgtcc tccgactccc cgcgccgccg agaccaggct cccgctccgg ttgcggccgc 180
accgccctcc gcggccgccc cctggggatc cagcgagcgc ggtcgtcctt ggtggaagga 240
accatgaact ggcatctccc cctcttcctc ttggcctctg tgacgctgcc ttccatctgc 300
tcccacttca atcctctgtc tctcgaggaa ctaggctcca acacggggat ccaggttttc 360
aatcagattg tgaagtcgag gcctcatgac aacatcgtga tctctcccca tgggattgcg 420
tcggtcctgg ggatgcttca gctgggggcg gacggcagga ccaagaagca gctcgccatg 480
gtgatgagat acggcgtaaa tggagttggt aaaatattaa agaagatcaa caaggccatc 540
gtctccaaga agaataaaga cattgtgaca gtggctaacg ccgtgtttgt taagaatgcc 600
tctgaaattg aagtgccttt tgttacaagg aacaaagatg tgttccagtg tgaggtccgg 660
aatgtgaact ttgaggatcc agcctctgcc tgtgattcca tcaatgcatg ggttaaaaat 720
gaaaccaggg atatgattga caatctgctg tccccagatc ttattgatgg tgtgctcacc 780
agactggtcc tcgtcaacgc agtgtatttc aagggtctgt ggaaatcacg gttccaaccc 840
gagaacacaa agaaacgcac tttcgtggca gccgacggga aatcctatca agtgccaatg 900
ctggcccagc tctccgtgtt ccggtgtggg tcgacaagtg cccccaatga tttatggtac 960
aacttcattg aactgcccta ccacggggaa agcatcagca tgctgattgc actgccgact 1020
gagagctcca ctccgctgtc tgccatcatc ccacacatca gcaccaagac catagacagc 1080
tggatgagca tcatggtgcc caagagggtg caggtgatcc tgcccaagtt cacagctgta 1140
gcacaaacag atttgaagga gccgctgaaa gttcttggca ttactgacat gtttgattca 1200
tcaaaggcaa attttgcaaa aataacaaca gggtcagaaa acctccatgt ttctcatatc 1260
ttgcaaaaag caaaaattga agtcagtgaa gatggaacca aagcttcagc agcaacaact 1320
gcaattctca ttgcaagatc atcgcctccc tggtttatag tagacagacc ttttctgttt 1380
ttcatccgac ataatcctac aggtgctgtg ttattcatgg ggcagataaa caaaccctga 1440
agagtataca aaagaaacca tgcaaagcaa cgactacttt gctacgaaga aagactcctt 1500
tcctgcatct ttcatagttc tgttaaatat ttttgtacat cgcttctttt tcaaaactag 1560
ttcttaggaa cagactcgat gcaagtgttt ctgttctggg aggtattgga gggaaaaaac 1620
aagcaggatg gctggaacac tgtactgagg aatgaataga aaggcttcca gatgtctaaa 1680
agattcttta aactactgaa ctgttaccta ggttaacaac cctgttgagt atttgctgtt 1740
tgtccagttc aggaattttt gttttgtttt gtctatatgt gcggcttttc agaagaaatt 1800
taatcagtgt gacagaaaaa aaaatgtttt atggtagctt ttacttttta tgaaaaaaaa 1860
attatttgcc ttttaaattc ttttccccca tccccctcca aagtcttgat agcaagcgtt 1920
attttggggg tagaaacggt gaaatctcta gcctctttgt gtttttgttg ttgttgttgt 1980
tgttgtttta tataatgcat gtattcacta aaataaaatt taaaaaactc ctgtcttgct 2040
agacaaggtt gctgttgtgc agtgtgcctg tcactactgg tctgtactcc ttggatttgc 2100
atttttgtat tttgtacaaa gtaaaaataa actgttatga gtagtaaaaa taaagctatt 2160
tctctgctat ttgaaaatac aatagaagaa actgagcctt ttagacattc gtcagcctct 2220
tctaataaac ctttgtacta tgtaaacatc aggaaattc 2259
<210> 261
<211> 3297
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3297)
<223> SLC20A1 mRNA
<400> 261
ggagtgatgg ctgccggcgc tctctgcgtg gttcttcttc tcggccgctg aaacccccgc 60
ggctgcttcc tgggaaggtc gtgagtcccg ctgagctgtc cccggtgccg ccgacccggg 120
ccgtgtgccc gtggctccag ccgctgtcgc ctcgatctcc tcgtctcccg ctccgccctc 180
ccttttccct ggatgaactt gcgtcctttc tcttctccgc catggaattc tgctccgtgc 240
ttttagccct cctgagccaa agaaacccca gacaacagat gcccatacgc agcgtatagc 300
agtaactccc cagctcggtt tctgtgccgt agtttacagt atttaatttt atataatata 360
tattatttat tatagcattt ttgatacctc atattctgtt tacacatctt gaaaggcgct 420
cagtagttct cttactaaac aaccactact ccagagaatg gcaacgctga ttaccagtac 480
tacagctgct accgccgctt ctggtccttt ggtggactac ctatggatgc tcatcctggg 540
cttcattatt gcatttgtct tggcattctc cgtgggagcc aatgatgtag caaattcttt 600
tggtacagct gtgggctcag gtgtagtgac cctgaagcaa gcctgcatcc tagctagcat 660
ctttgaaaca gtgggctctg tcttactggg ggccaaagtg agcgaaacca tccggaaggg 720
cttgattgac gtggagatgt acaactcgac tcaagggctg ctgatggccg gctcagtcag 780
tgctatgttt ggttctgctg tgtggcaact cgtggcttcg tttttgaagc tccctatttc 840
tggaacccat tgtattgttg gtgcaactat tggtttctcc ctcgtggcaa aggggcagga 900
gggtgtcaag tggtctgaac tgataaaaat tgtgatgtct tggttcgtgt ccccactgct 960
ttctggaatt atgtctggaa ttttattctt cctggttcgt gcattcatcc tccataaggc 1020
agatccagtt cctaatggtt tgcgagcttt gccagttttc tatgcctgca cagttggaat 1080
aaacctcttt tccatcatgt atactggagc accgttgctg ggctttgaca aacttcctct 1140
gtggggtacc atcctcatct cggtgggatg tgcagttttc tgtgccctta tcgtctggtt 1200
ctttgtatgt cccaggatga agagaaaaat tgaacgagaa ataaagtgta gtccttctga 1260
aagcccctta atggaaaaaa agaatagctt gaaagaagac catgaagaaa caaagttgtc 1320
tgttggtgat attgaaaaca agcatcctgt ttctgaggta gggcctgcca ctgtgcccct 1380
ccaggctgtg gtggaggaga gaacagtctc attcaaactt ggagatttgg aggaagctcc 1440
agagagagag aggcttccca gcgtggactt gaaagaggaa accagcatag atagcaccgt 1500
gaatggtgca gtgcagttgc ctaatgggaa ccttgtccag ttcagtcaag ccgtcagcaa 1560
ccaaataaac tccagtggcc actaccagta tcacaccgtg cataaggatt ccggcctgta 1620
caaagagcta ctccataaat tacatcttgc caaggtggga gattgcatgg gagactccgg 1680
tgacaaaccc ttaaggcgca ataatagcta tacttcctat accatggcaa tatgtggcat 1740
gcctctggat tcattccgtg ccaaagaagg tgaacagaag ggcgaagaaa tggagaagct 1800
gacatggcct aatgcagact ccaagaagcg aattcgaatg gacagttaca ccagttactg 1860
caatgctgtg tctgaccttc actcagcatc tgagatagac atgagtgtca aggcagagat 1920
gggtctaggt gacagaaaag gaagtaatgg ctctctagaa gaatggtatg accaggataa 1980
gcctgaagtc tctctcctct tccagttcct gcagatcctt acagcctgct ttgggtcatt 2040
cgcccatggt ggcaatgacg taagcaatgc cattgggcct ctggttgctt tatatttggt 2100
ttatgacaca ggagatgttt cttcaaaagt ggcaacacca atatggcttc tactctatgg 2160
tggtgttggt atctgtgttg gtctgtgggt ttggggaaga agagttatcc agaccatggg 2220
gaaggatctg acaccgatca caccctctag tggcttcagt attgaactgg catctgccct 2280
cactgtggtg attgcatcaa atattggcct tcccatcagt acaacacatt gtaaagtggg 2340
ctctgttgtg tctgttggct ggctccggtc caagaaggct gttgactggc gtctctttcg 2400
taacattttt atggcctggt ttgtcacagt ccccatttct ggagttatca gtgctgccat 2460
catggcaatc ttcagatatg tcatcctcag aatgtgaagc tgtttgagat taaaatttgt 2520
gtcaatgttt gggaccatct taggtattcc tgctcccctg aagaatgatt acagtgttaa 2580
cagaagactg acaagagtct ttttatttgg gagccagagg agggaagtgt tacttgtgct 2640
ataactgctt ttgtgctaaa tatgaattgt ctcaaaatta gctgtgtaaa atagcccggg 2700
ttccactggc tcctgctgag gtcccctttc cttctgggct gtgaattcct gtacatattt 2760
ctctactttt tgtatcaggc ttcaattcca ttatgtttta atgttgtctc tgaagatgac 2820
ttgtgatttt tttttctttt ttttaaacca tgaagagccg tttgacagag catgctctgc 2880
gttgttggtt tcaccagctt ctgccctcac atgcacaggg atttaacaac aaaaatataa 2940
ctacaacttc ccttgtagtc tcttatataa gtagagtcct tggtactctg ccctcctgtc 3000
agtagtggca ggatctattg gcatattcgg gagcttctta gagggatgag gttctttgaa 3060
cacagtgaaa atttaaatta gtaacttttt tgcaagcagt ttattgactg ttattgctaa 3120
gaagaagtaa gaaagaaaaa gcctgttggc aatcttggtt atttctttaa gatttctggc 3180
agtgtgggat ggatgaatga agtggaatgt gaactttggg caagttaagt gggacagcct 3240
tccatgttca tttgtctacc tcttaactga ataaaaaagc ctacagtttt tagaaaa 3297
<210> 262
<211> 8057
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(8057)
<223> SLIT2 mRNA
<400> 262
acttggtgtt atttatttgg gaagcgcccg gacggcggag cttggcggcg gcggtggtgg 60
tggctgccgc agactgtggt taaaaaaaag aaggcggcgg cggcggcggc ggcggaggcg 120
gaggcagctg cgaggcatgg gagcgccgaa gcgcccaggc gcaggccgaa gctgccgcgc 180
tttctgggca cggcgggagt gctgagcaga aaggggagcg ccgggggccc gcagccggct 240
ccggaggcgc gggccgggtt tttgtttggc tacgctgagc gccagtcagc cccagcgaac 300
aactccagtt acgacaacaa cccaccttcc ttccagacaa gcgagacttg ggctgctgcg 360
tccgtcctat tgtttagaca cttgccaggg gctccggagt cggcagagcc accgagtccc 420
cgctctgagt cgtcgccctc cctctccccg acctcgctcc ctggagcggg aggccaggaa 480
agcagcggga gaggggaagg ggctagaagg agaaggacta cccgggactg cggccgccgc 540
gtcaggtgca gcgccaggag ccgggcggcg tcgccacgcc ggcaggggta ccgccactgt 600
ggccttgggg gacggaattc aaagcctggg aaaagttgct gcactttgag aaggacgaac 660
cactagtggg agaccgccgg gggccggccg tggctctgcg ccctccggaa cccggctctt 720
gtttcttcta cctttgccat caggtgtctg ccgcggagct gcggcttatc tgggagacga 780
gcggggttga cacgcgcgca cacactactg ccattcagct gccgcctggc tctgcctgga 840
gtagtggatc ccacccgccc acctgccacc gagccattct ccagtacgcc ccagcaggac 900
gctgacacct ccaaccttgg cctttgcctt tccactcctt ccggtctgcc tggtttttaa 960
gtccgccccc agtcagtccc cactcagtct tcgcagcagc tctcatcctc cacttggcct 1020
cttggagttc ctcgccggag tgctgactag tggatatttc tgcccggctg cggcggcccg 1080
actgcccttt tgtcttttct gcgtgacctc ggggcaggtc ctggtgcaga gcgtcgccaa 1140
ggacgccgag cgggaggcgg gattgcccag acatccttca gcgaagtgca tgtgtgtttg 1200
taaaccatcg ttggctgtcg ggagaccgcg aggaccggtc caggctgcgg cggagtcgag 1260
ggcgagggag aggccgcgtg agtgagcaga gtccagagcc gtgcgccccc agaactgcgc 1320
gtccgccccg tgcacccccg cgcgccatgc ccagttgccc cgcgcgctct gctacgggcc 1380
cgctgggctt ccgcgccttc tagcttccgg agcccacttt gatcggggcc ataataccta 1440
ttgagatccc ctcttctgtc ttgtaccttc gccactggca tcggatttgc agaagcgtgc 1500
gtgggatcag aggaccgccc tccccacaac aaccggcccc tgcatcttag cagccgttgg 1560
aagccccagc tcttttaccg ccaagttcat ccttgggaga cagaagacgc gtgatctcct 1620
ctccgctgct cttggggtct ccttgcagcc ctggccaggc ggattcatcc tcaggaccta 1680
aagttgccca aggagctcct gctctgccag aggagggtgg agagggcggt gggaggcgtg 1740
tgcctgagtg ggctctactg ccttgttcca tattatttgg tgcacatttt ccctggcact 1800
ctgggttgct agccccgccg ggcactgggc ctcagacact gcgcggttcc ctcggagcag 1860
caagctaaag aaagccccca gtgccggcga ggaaggaggc ggcggggaaa gatgcgcggc 1920
gttggctggc agatgctgtc cctgtcgctg gggttagtgc tggcgatcct gaacaaggtg 1980
gcaccgcagg cgtgcccggc gcagtgctct tgctcgggca gcacagtgga ctgtcacggg 2040
ctggcgctgc gcagcgtgcc caggaatatc ccccgcaaca ccgagagact ggatttaaat 2100
ggaaataaca tcacaagaat tacgaagaca gattttgctg gtcttagaca tctaagagtt 2160
cttcagctta tggagaataa gattagcacc attgaaagag gagcattcca ggatcttaaa 2220
gaactagaga gactgcgttt aaacagaaat caccttcagc tgtttcctga gttgctgttt 2280
cttgggactg cgaagctata caggcttgat ctcagtgaaa accaaattca ggcaatccca 2340
aggaaagctt tccgtggggc agttgacata aaaaatttgc aactggatta caaccagatc 2400
agctgtattg aagatggggc attcagggct ctccgggacc tggaagtgct cactctcaac 2460
aataacaaca ttactagact ttctgtggca agtttcaacc atatgcctaa acttaggact 2520
tttcgactgc attcaaacaa cctgtattgt gactgccacc tggcctggct ctccgactgg 2580
cttcgccaaa ggcctcgggt tggtctgtac actcagtgta tgggcccctc ccacctgaga 2640
ggccataatg tagccgaggt tcaaaaacga gaatttgtct gcagtggtca ccagtcattt 2700
atggctcctt cttgtagtgt tttgcactgc cctgccgcct gtacctgtag caacaatatc 2760
gtagactgtc gtgggaaagg tctcactgag atccccacaa atcttccaga gaccatcaca 2820
gaaatacgtt tggaacagaa cacaatcaaa gtcatccctc ctggagcttt ctcaccatat 2880
aaaaagctta gacgaattga cctgagcaat aatcagatct ctgaacttgc accagatgct 2940
ttccaaggac tacgctctct gaattcactt gtcctctatg gaaataaaat cacagaactc 3000
cccaaaagtt tatttgaagg actgttttcc ttacagctcc tattattgaa tgccaacaag 3060
ataaactgcc ttcgggtaga tgcttttcag gatctccaca acttgaacct tctctcccta 3120
tatgacaaca agcttcagac catcgccaag gggacctttt cacctcttcg ggccattcaa 3180
actatgcatt tggcccagaa cccctttatt tgtgactgcc atctcaagtg gctagcggat 3240
tatctccata ccaacccgat tgagaccagt ggtgcccgtt gcaccagccc ccgccgcctg 3300
gcaaacaaaa gaattggaca gatcaaaagc aagaaattcc gttgttcagc taaagaacag 3360
tatttcattc caggtacaga agattatcga tcaaaattaa gtggagactg ctttgcggat 3420
ctggcttgcc ctgaaaagtg tcgctgtgaa ggaaccacag tagattgctc taatcaaaag 3480
ctcaacaaaa tcccggagca cattccccag tacactgcag agttgcgtct caataataat 3540
gaatttaccg tgttggaagc cacaggaatc tttaagaaac ttcctcaatt acgtaaaata 3600
aactttagca acaataagat cacagatatt gaggagggag catttgaagg agcatctggt 3660
gtaaatgaaa tacttcttac gagtaatcgt ttggaaaatg tgcagcataa gatgttcaag 3720
ggattggaaa gcctcaaaac tttgatgttg agaagcaatc gaataacctg tgtggggaat 3780
gacagtttca taggactcag ttctgtgcgt ttgctttctt tgtatgataa tcaaattact 3840
acagttgcac caggggcatt tgatactctc cattctttat ctactctaaa cctcttggcc 3900
aatcctttta actgtaactg ctacctggct tggttgggag agtggctgag aaagaagaga 3960
attgtcacgg gaaatcctag atgtcaaaaa ccatacttcc tgaaagaaat acccatccag 4020
gatgtggcca ttcaggactt cacttgtgat gacggaaatg atgacaatag ttgctcccca 4080
ctttctcgct gtcctactga atgtacttgc ttggatacag tcgtccgatg tagcaacaag 4140
ggtttgaagg tcttgccgaa aggtattcca agagatgtca cagagttgta tctggatgga 4200
aaccaattta cactggttcc caaggaactc tccaactaca aacatttaac acttatagac 4260
ttaagtaaca acagaataag cacgctttct aatcagagct tcagcaacat gacccagctc 4320
ctcaccttaa ttcttagtta caaccgtctg agatgtattc ctcctcgcac ctttgatgga 4380
ttaaagtctc ttcgattact ttctctacat ggaaatgaca tttctgttgt gcctgaaggt 4440
gctttcaatg atctttctgc attatcacat ctagcaattg gagccaaccc tctttactgt 4500
gattgtaaca tgcagtggtt atccgactgg gtgaagtcgg aatataagga gcctggaatt 4560
gctcgttgtg ctggtcctgg agaaatggca gataaacttt tactcacaac tccctccaaa 4620
aaatttacct gtcaaggtcc tgtggatgtc aatattctag ctaagtgtaa cccctgccta 4680
tcaaatccgt gtaaaaatga tggcacatgt aatagtgatc cagttgactt ttaccgatgc 4740
acctgtccat atggtttcaa ggggcaggac tgtgatgtcc caattcatgc ctgcatcagt 4800
aacccatgta aacatggagg aacttgccac ttaaaggaag gagaagaaga tggattctgg 4860
tgtatttgtg ctgatggatt tgaaggagaa aattgtgaag tcaacgttga tgattgtgaa 4920
gataatgact gtgaaaataa ttctacatgt gtcgatggca ttaataacta cacatgcctt 4980
tgcccacctg agtatacagg tgagttgtgt gaggagaagc tggacttctg tgcccaggac 5040
ctgaacccct gccagcacga ttcaaagtgc atcctaactc caaagggatt caaatgtgac 5100
tgcacaccag ggtacgtagg tgaacactgc gacatcgatt ttgacgactg ccaagacaac 5160
aagtgtaaaa acggagccca ctgcacagat gcagtgaacg gctatacgtg catatgcccc 5220
gaaggttaca gtggcttgtt ctgtgagttt tctccaccca tggtcctccc tcgtaccagc 5280
ccctgtgata attttgattg tcagaatgga gctcagtgta tcgtcagaat aaatgagcca 5340
atatgtcagt gtttgcctgg ctatcaggga gaaaagtgtg aaaaattggt tagtgtgaat 5400
tttataaaca aagagtctta tcttcagatt ccttcagcca aggttcggcc tcagacgaac 5460
ataacacttc agattgccac agatgaagac agcggaatcc tcctgtataa gggtgacaaa 5520
gaccatatcg cggtagaact ctatcggggg cgtgttcgtg ccagctatga caccggctct 5580
catccagctt ctgccattta cagtgtggag acaatcaatg atggaaactt ccacattgtg 5640
gaactacttg ccttggatca gagtctctct ttgtccgtgg atggtgggaa ccccaaaatc 5700
atcactaact tgtcaaagca gtccactctg aattttgact ctccactcta tgtaggaggc 5760
atgccaggga agagtaacgt ggcatctctg cgccaggccc ctgggcagaa cggaaccagc 5820
ttccacggct gcatccggaa cctttacatc aacagtgagc tgcaggactt ccagaaggtg 5880
ccgatgcaaa caggcatttt gcctggctgt gagccatgcc acaagaaggt gtgtgcccat 5940
ggcacatgcc agcccagcag ccaggcaggc ttcacctgcg agtgccagga aggatggatg 6000
gggcccctct gtgaccaacg gaccaatgac ccttgccttg gaaataaatg cgtacatggc 6060
acctgcttgc ccatcaatgc gttctcctac agctgtaagt gcttggaggg ccatggaggt 6120
gtcctctgtg atgaagagga ggatctgttt aacccatgcc aggcgatcaa gtgcaagcat 6180
gggaagtgca ggctttcagg tctggggcag ccctactgtg aatgcagcag tggatacacg 6240
ggggacagct gtgatcgaga aatctcttgt cgaggggaaa ggataagaga ttattaccaa 6300
aagcagcagg gctatgctgc ttgccaaaca accaagaagg tgtcccgatt agagtgcaga 6360
ggtgggtgtg caggagggca gtgctgtgga ccgctgagga gcaagcggcg gaaatactct 6420
ttcgaatgca ctgacggctc ctcctttgtg gacgaggttg agaaagtggt gaagtgcggc 6480
tgtacgaggt gtgtgtccta aacacactcc cggcagctct gtctttggaa aaggttgtat 6540
acttcttgac cgtgtgggac taatgaatgc ttcatagtgg aaatatttga aatatattgt 6600
aaaatacaga acagacttat ttttattatg agaataaaga ctttttttct gcatttggaa 6660
aaaaaaaaaa agaaatgctt gaactaaagc ttcccctatg ctggagaagt atgaagaaag 6720
atatacctgg agacattaga acagcgatgg gaaccattgc aactcgggtc catctttgta 6780
acatgctgaa gacaagcaga agcacatgca cgagggacag aggagctact gtgcactgct 6840
gtgaaattgc ccagagcata aaacctgtgt accctccttc acatcaacca agttcactag 6900
gacataccaa gcacatgcgt gtgaatgagg atgcaaggca agagaatgga actccagaat 6960
tcacagatag aacaaatgga tgagaaatat ttcatgcaaa atataaagtg tcctgaggat 7020
ctgggttcca tttacgagag gaaatgaaag tgctaaaata aattttatct tccttttaaa 7080
tgtcagcatg tcagcagaag cagcacacaa aagtctttac cattttccag tattaatttt 7140
tttgtaatat aaatgataaa ggagatgata aagaaccaat agattattga taaataaatt 7200
agtaataata tgattttttg tttctatgag ttctaaacag ccctatacag tattcagttt 7260
ccatgagaaa tatttattgt atcaaagtac attgtactta acattttagg ccatcctttt 7320
actgttcctt gatgctttaa tatatattaa tttataatta tcctgatatt tttgtacatt 7380
tttcaaactt aaaaatcagg attttttttt tttttttttt ggcaatagta ctaacatagg 7440
gttttatctt gggatacata tgtattggtc tgtttgttga ccttgacatc tgatcactga 7500
tgtcaatgac ctactggcct cattcaggac acctgcagag agtatgcaaa gtccgagaga 7560
ggaaaacaga aatctgtatg tgagatggtc attgtacaga aagaagtggc ccctctgcaa 7620
catgtcctca cagaaacgaa atggtgtgta gcaatcaaca ctagaaagta gaccttttgc 7680
aaattaatat gtccttgacc ttttttgccc ttttgtgggg gtgaggtggg gataaaaaga 7740
ctgtcatatc aagaactgtg acttttcttt ccctcaaaca ataaaactcc tttattatct 7800
taatgctccc atgttaacat gtttgctgct aaattacaat gtagaattga taatggttta 7860
tagtgaactg tgctcttccc tcattaaaat cccagggtgc cctgtaaaga tgcagatgtt 7920
tcttcctgaa aacttctttt tttacaaaga aaattagatg tacatgtata attcagtgtg 7980
ctttgtcttt ctccagatta atatcggtta cactgctgat gtttgtaaat taaacagata 8040
tttacttcat taaaaaa 8057
<210> 263
<211> 6240
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6240)
<223> SMURF2 mRNA
<400> 263
agacaagagg gcgggtggag gaggaagcgg ccgagcccag agttctgctc cggcgccccc 60
gagcaccgcc cgcttcagcc gaccagcccc gtcggctact gggcctcgcc gagacgagag 120
gagggaaagg cctcggcggc cgcgaggagg cggcgggggc gcgggcggag gcggcgcggg 180
cggccgcggc tgccgctttg ttgtgcggcc cgggccgagg aaggagaagt gggaggaggg 240
gggagctcgg cgtcccgctc cctccgcggc tcatggcgac gactctcggc acatccggga 300
ccctccggcc gtggcggccg aggcgccggc tgctcgggcc ccagccccgg ccgctgtggt 360
gactccgccg cgcctcgccg tcgcccccgt gccgcccgcc gcccccgccg cccccgccgc 420
cggggacatg tctaaccccg gaggccggag gaacgggccc gtcaagctgc gcctgacagt 480
actctgtgca aaaaacctgg tgaaaaagga ttttttccga cttcctgatc catttgctaa 540
ggtggtggtt gatggatctg ggcaatgcca ttctacagat actgtgaaga atacgcttga 600
tccaaagtgg aatcagcatt atgacctgta tattggaaag tctgattcag ttacgatcag 660
tgtatggaat cacaagaaga tccataagaa acaaggtgct ggatttctcg gttgtgttcg 720
tcttctttcc aatgccatca accgcctcaa agacactggt tatcagaggt tggatttatg 780
caaactcggg ccaaatgaca atgatacagt tagaggacag atagtagtaa gtcttcagtc 840
cagagaccga ataggcacag gaggacaagt tgtggactgc agtcgtttat ttgataacga 900
tttaccagac ggctgggaag aaaggagaac cgcctctgga agaatccagt atctaaacca 960
tataacaaga actacgcaat gggagcgccc aacacgaccg gcatccgaat attctagccc 1020
tggcagacct cttagctgct ttgttgatga gaacactcca attagtggaa caaatggtgc 1080
aacatgtgga cagtcttcag atcccaggct ggcagagagg agagtcaggt cacaacgaca 1140
tagaaattac atgagcagaa cacatttaca tactcctcca gacctaccag aaggctatga 1200
acagaggaca acgcaacaag gccaggtgta tttcttacat acacagactg gtgtgagcac 1260
atggcatgat ccaagagtgc ccagggatct tagcaacatc aattgtgaag agcttggtcc 1320
attgcctcct ggatgggaga tccgtaatac ggcaacaggc agagtttatt tcgttgacca 1380
taacaacaga acaacacaat ttacagatcc tcggctgtct gctaacttgc atttagtttt 1440
aaatcggcag aaccaattga aagaccaaca gcaacagcaa gtggtatcgt tatgtcctga 1500
tgacacagaa tgcctgacag tcccaaggta caagcgagac ctggttcaga aactaaaaat 1560
tttgcggcaa gaactttccc aacaacagcc tcaggcaggt cattgccgca ttgaggtttc 1620
cagggaagag atttttgagg aatcatatcg acaggtcatg aaaatgagac caaaagatct 1680
ctggaagcga ttaatgataa aatttcgtgg agaagaaggc cttgactatg gaggcgttgc 1740
cagggaatgg ttgtatctct tgtcacatga aatgttgaat ccatactatg gcctcttcca 1800
gtattcaaga gatgatattt atacattgca gatcaatcct gattctgcag ttaatccgga 1860
acatttatcc tatttccact ttgttggacg aataatggga atggctgtgt ttcatggaca 1920
ttatattgat ggtggtttca cattgccttt ttataagcaa ttgcttggga agtcaattac 1980
cttggatgac atggagttag tagatccgga tcttcacaac agtttagtgt ggatacttga 2040
gaatgatatt acaggtgttt tggaccatac cttctgtgtt gaacataatg catatggtga 2100
aattattcag catgaactta aaccaaatgg caaaagtatc cctgttaatg aagaaaataa 2160
aaaagaatat gtcaggctct atgtgaactg gagattttta cgaggcattg aggctcaatt 2220
cttggctctg cagaaaggat ttaatgaagt aattccacaa catctgctga agacatttga 2280
tgagaaggag ttagagctca ttatttgtgg acttggaaag atagatgtta atgactggaa 2340
ggtaaacacc cggttaaaac actgtacacc agacagcaac attgtcaaat ggttctggaa 2400
agctgtggag ttttttgatg aagagcgacg agcaagattg cttcagtttg tgacaggatc 2460
ctctcgagtg cctctgcagg gcttcaaagc attgcaaggt gctgcaggcc cgagactctt 2520
taccatacac cagattgatg cctgcactaa caacctgccg aaagcccaca cttgcttcaa 2580
tcgaatagac attccaccct atgaaagcta tgaaaagcta tatgaaaagc tgctaacagc 2640
cattgaagaa acatgtggat ttgctgtgga atgacaagct tcaaggattt acccaggact 2700
ctatttatac aaccctgact gacagcctcc tttcagcaga gtttcaaaga atatgctgaa 2760
atacaggaaa acactccccc cccccccctt tttttttttt tttttacatt ttaggacact 2820
gtgaggggaa aggacaattt tgaaattcct tttcaaggaa aaaaaaggtc tttatgcttt 2880
gccatgaggc cacattcagc tgctatttaa acttaatatc ttgaacctaa agaatgctga 2940
cttttcctac atttccagag ttaggcagta ttctacactt aaagactact actattttta 3000
taaaaggtaa tctattcaaa tttcttcaca gatttcaagt ctctcaaaca tcaagacaac 3060
ttcagcagtc ggtacaagtc acatttcatt ttgattgaat acatgatctt gaacagctcc 3120
tgtacttgct ctttgtaaaa aaaaataaaa ttattttgaa ttattctacc tttgtaaaca 3180
attggctaaa agaatcatct ttaagaaatt aagccattta catgtttgtg tttttctata 3240
gcagagcatt atattttgca ttatatgttt caacctagtc taagtgggtc ttttttacat 3300
ttttcaagaa cggatttcct ggaatacagc gatataattt tggttgtcaa attcctaatg 3360
caaccattta gtctaaactt agtcatttat ttgtgacaat aagatgtgtt caggggctcc 3420
ctgtttttaa gagactcttt taaaaaaaaa aaaacctaat gtttttatct tgagtcaata 3480
tgattaggta ttttggattt acttttaatc ttaaaatact gcatttttat agcttctcag 3540
agcatgtgga tgggatggga ttttcgttat tttgctgggt cagcttatct ttaatatatg 3600
gactattcct ataaaccaaa gtctctgaca agtgcaccta atttatattg tattttaact 3660
acagtgtaag tttccattaa caaaaccatc ctaaagcgtt aactgctcat aattttaatc 3720
agctacagtt atgaaaaagg aagaattttg ctctaaagat tattaataag cttagaaaat 3780
cctgctttta cctaacagaa tgaagtgggg ttgaggggcg gtagtatgaa cagtgattct 3840
aactctatgg cgtaaattac tttgaagagt tcattttgga agtaagggaa tcccgcttcc 3900
cttggtgttg aagatctgca tctgattttg aaacgtccag atttagcttt caaggtgcgt 3960
gcatgttgaa tgatccagaa gcaacgaaaa ctctggggtg agggattgaa aaaatctgaa 4020
atcacagttg gatttttaaa ttcaaccatc aaaaatatgt actatcagtt tttttttaca 4080
ttgatgtgaa ataagcaaat tttcatgata attaagctgc aaaatttaaa gttatcaagt 4140
aaataggtcc tctgtgttct gtttcatgtg atggagtggg tttcagtctg tgttcttgga 4200
gccaaagggt tcctcagggg tgcctcagga gtaatggttt aagagaagag gggcaatgag 4260
agggagcgag ggggaaggcc tagttggtat ttgagcaggg gccttaggct ccatatcccc 4320
acccccttta cccagaacag cccatttttc ttatgtatat tggaatttca agtaagcttt 4380
catggggtgc agtggggcgg ggaggaatgg atgggataaa aaaagtggag attttgctgc 4440
tttaaaaaag ttgagaacta cttgtgtagt ttttaagtat tttaatgtat ttcatttggc 4500
caaattcaac tgccacaagc aagctagtca tagttgtaac tgtgcagtgg taatatgctt 4560
atgcctacct ttttcctctc aaacaatttg ttttttttac attgcattct gagtactgaa 4620
gagcatcttg aaatgtatgg aagtggtttc tatgctattt gataatcagt aatgttcagc 4680
tgtcatgata gtactttact ggttgcagac ccatctctct tttatattaa agcactagtg 4740
cagtttataa ttgtgcctac ttttaaaatc tttcagtaaa aaagtacata atgaatacag 4800
aaatcataac tgacagggat acagtaataa tgaaatgcta ctatcactta ttttaatata 4860
caatataaag caggcaaata ccattgcttt ttgagtgcct ttttaacttt atactaatga 4920
cttaatagag ctttaaaaga aagaaattgg ctgggcatgg tggctcacac ctgtaatccc 4980
agcactttgg gaggccgagg tgggcggatc acctgaggtc aggagttcga gaccagcctg 5040
gccaacgtgg tgaaaccctg tctctactaa aaatacaaaa tttagccggg catggtggcg 5100
cactcctgta atccaactac ttgggaggct gaggcaggag aattgcttga atctgggagg 5160
cagagattgc agtgagccga gatcgcacca ctgcactcca gcctgggcga caagagtgag 5220
actccgtccc cgcccaaaaa aaaaaaaaaa agaaattact ctccataaca gtctatgtta 5280
tcaccaacat atataaaaac atgatttaga tttccatttc aaagttacat tacccgatta 5340
cttccaaata ggtgctaagc aaaaaccccc aatgtattat tgaaccatgg acttgcacct 5400
catgtttaat gtgaatattt atttccatgt ccctcttaac tggttttttc ttgtcttccc 5460
tctagctgta ttgttatttc agatatgtga tatctgtttt catactcttg cctttccatc 5520
atgaatgctt agttatgaac agagattcct ttgtagagct cataggcagt acagagaggt 5580
aagtcttgcc tcagagggcc ttgtatcttg gtgtagtttt taaatagtgc atagtgtata 5640
gtgtatagtg tacattttgt tttgcacata gtttgttgcc ccgaatgggt tttttaccaa 5700
gccttttttt ctttcatgta tttacagtcc ggagcacaag attctcttct ttcaaataca 5760
atgtaattcg ctttacttta caacactaaa tctgggcttt gaatttccag tgcattggac 5820
tgattggatt gttgggagtt agaggctgtt ccaaccatcc ttagtttggg agagtggctc 5880
cttctgcttg ttttctaagc gtacagtcaa cgggtgccat ttgtggtatt taacatgtta 5940
ggatgattgt tccaaatgct gagttgtttt atttctagat gtaattagtt cactttatgt 6000
aatattcttc tctcagactg actttaaaaa caaagtttta tcattttcat tgtatttgta 6060
tttattacag agtgttttag ctttgatatt ctttgtattt tcattcattt gttacatgag 6120
ctttatcagt aacatctgta taaatggttt ttaaaaatta actatgtatg tgcccatgcc 6180
gaagtcgagc aataaaatca atgctgtttg cactgtcaca gcatcaacgt ttttaaagaa 6240
6240
<210> 264
<211> 4978
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4978)
<223> STAT3 mRNA
<400> 264
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60
ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120
ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180
cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg 240
atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag 300
ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt 360
caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc 420
ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag 480
cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag 540
attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc 600
actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag 660
cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag 720
aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag 780
agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg 840
cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag 900
ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg 960
gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta 1020
gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa 1080
attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag 1140
caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc 1200
tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag 1260
accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat 1320
cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga 1380
tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac 1440
aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat 1500
gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc 1560
tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca 1620
gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac 1680
aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc 1740
tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg 1800
agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca 1860
gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc 1920
ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg 1980
aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact 2040
aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact 2100
ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac 2160
acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg 2220
gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag 2280
gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt 2340
agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat 2400
accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat 2460
ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag 2520
ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag 2580
atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat 2640
ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg 2700
agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc 2760
taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg 2820
ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc 2880
agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc 2940
ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt 3000
gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc 3060
tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt 3120
tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact 3180
ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg 3240
aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag 3300
tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc 3360
agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc 3420
tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa 3480
gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa 3540
cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga 3600
gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg 3660
gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg 3720
gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga 3780
tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg 3840
ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct 3900
ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac 3960
tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct 4020
tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct 4080
tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct 4140
ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc 4200
ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc 4260
tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc 4320
ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga 4380
attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg 4440
agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat 4500
aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta 4560
aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca 4620
tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag 4680
ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc 4740
actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta 4800
taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat 4860
agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg 4920
tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa 4978
<210> 265
<211> 3868
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3868)
<223> STC1 mRNA
<400> 265
agtttgcaaa agccagaggt gcaagaagca gcgactgcag cagcagcagc agcagcggcg 60
gtggcagcag cagcagcagc ggcggcagca gcagcagcag cggaggcacc ggtggcagca 120
gcagcatcac cagcaacaac aacaaaaaaa aatcctcatc aaatcctcac ctaagctttc 180
agtgtatcca gatccacatc ttcactcaag ccaggagagg gaaagaggaa aggggggcag 240
gaaaaaaaaa aaacccaaca acttagcgga aacttctcag agaatgctcc aaaactcagc 300
agtgcttctg gtgctggtga tcagtgcttc tgcaacccat gaggcggagc agaatgactc 360
tgtgagcccc aggaaatccc gagtggcggc tcaaaactca gctgaagtgg ttcgttgcct 420
caacagtgct ctacaggtcg gctgcggggc ttttgcatgc ctggaaaact ccacctgtga 480
cacagatggg atgtatgaca tctgtaaatc cttcttgtac agcgctgcta aatttgacac 540
tcagggaaaa gcattcgtca aagagagctt aaaatgcatc gccaacgggg tcacctccaa 600
ggtcttcctc gccattcgga ggtgctccac tttccaaagg atgattgctg aggtgcagga 660
agagtgctac agcaagctga atgtgtgcag catcgccaag cggaaccctg aagccatcac 720
tgaggtcgtc cagctgccca atcacttctc caacagatac tataacagac ttgtccgaag 780
cctgctggaa tgtgatgaag acacagtcag cacaatcaga gacagcctga tggagaaaat 840
tgggcctaac atggccagcc tcttccacat cctgcagaca gaccactgtg cccaaacaca 900
cccacgagct gacttcaaca ggagacgcac caatgagccg cagaagctga aagtcctcct 960
caggaacctc cgaggtgagg aggactctcc ctcccacatc aaacgcacat cccatgagag 1020
tgcataacca gggagaggtt attcacaacc tcaccaaact agtatcattt taggggtgtt 1080
gacacaccag ttttgagtgt actgtgcctg gtttgatttt tttaaagtag ttcctatttt 1140
ctatccccct taaagaaaat tgcatgaaac taggcttctg taatcaatat cccaacattc 1200
tgcaatggca gcattcccac caacaaaatc catgtgacca ttctgcctct cctcaggaga 1260
aagtaccctc ttttaccaac ttcctctgcc atgtttttcc cctgctcccc tgagaccacc 1320
cccaaacaca aaacattcat gtaactctcc agccattgta atttgaagat gtggatccct 1380
ttagaacggt tgccccagta gagttagctg ataaggaaac tttatttaaa tgcatgtctt 1440
aaatgctcat aaagatgtta aatggaattc gtgttatgaa tctgtgctgg ccatggacga 1500
atatgaatgt cacatttgaa ttcttgatct ctaatgagct agtgtcttat ggtcttgatc 1560
ctccaatgtc taattttctt tccgacacat ttaccaaatt gcttgagcct ggctgtccaa 1620
ccagactttg agcctgcatc ttcttgcatc taatgaaaaa caaaaagcta acatctttac 1680
gtactgtaac tgctcagagc tttaaaagta tctttaacaa ttgtcttaaa accagagaat 1740
cttaaggtct aactgtggaa tataaatagc tgaaaactaa tgtactgtac ataaattcca 1800
gaggactctg cttaaacaaa gcagtatata ataactttat tgcatataga tttagttttg 1860
taacttagct ttatttttct tttcctggga atggaataac tatctcactt ccagatatcc 1920
acataaatgc tccttgtggc cttttttata actaaggggg tagaagtagt tttaattcaa 1980
catcaaaact taagatgggc ctgtatgaga caggaaaaac caacaggttt atctgaagga 2040
ccccaggtaa gatgttaatc tcccagccca cctcaaccca gaggctactc ttgacttaga 2100
cctatactga aagatctctg tcacatccaa ctggaaattc caggaaccaa aaagagcatc 2160
cctatgggct tggaccactt acagtgtgat aaggcctact atacattagg aagtggcagt 2220
tctttactcg tcccctttca tcggtgcctg gtactctggc aaatgatgat ggggtgggag 2280
actttccatt aaatcaatca ggaatgagtc aatcagcctt taggtcttta gtccggggga 2340
cttggggctg agagagtata aataaccctg ggctgtccag ccttaataga cttctcttac 2400
attttcgtcc tgtagcacgc tgcctgccaa agtagtcctg gcagctggac catctctgta 2460
ggatcgtaaa aaaatagaaa aaaagaaaaa aaaaagaaag aaagagggaa aaagagctgg 2520
tggtttgatc atttctgcca tgatgtttac aagatggcga ccaccaaagt caaacgacta 2580
acctatctat gaacaacagt agtttctcag ggtcactgtc cttgaaccca acagtccctt 2640
atgagcgtca ctgcccacca aaggtcaatg tcaagagagg aagagaggga ggaggggtag 2700
gactgcaggg gccactccaa actcgcttag gtagaaacta ttggtgcttg actctcacta 2760
ggctaaactc aagatttgac caaatcgagt gatagggatc ctggtgggag gagagagggc 2820
acatctccag aaaaatgaaa agcaatacaa ctttaccata aagcctttaa aaccagtaac 2880
gtgctgctca aggaccaaga gcaattgcag cagacccagc agcagcagca gcagcacaaa 2940
cattgctgcc tttgtcccca cacagcctct aagcgtgctg acatcagatt gttaagggca 3000
tttttatact cagaactgtc ccatccccag gtccccaaac ttatggacac tgccttagcc 3060
tcttggaaat caggtagacc atattctaag ttagactctt cccctccctc ccacacttcc 3120
cacccccagg caaggctgac ttctctgaat cagaaaagct attaaagttt gtgtgttgtg 3180
tccattttgc aaacccaact aagccaggac cccaatgcga caagtagttc atgagtattc 3240
ctagcaaatt tctctctttc ttcagttcag tagatttcct tttttctttt cttttttttt 3300
tttttttttt ttggctgtga cctcttcaaa ccgtggtacc cccccttttc tccccacgat 3360
gatatctata tatgtatcta caatacatat atctacacat acagaaagaa gcagttctca 3420
caatgttgct agttttttgc ttctctttcc cccaccctac tccctccaat tcccccttaa 3480
acttccaaag cttcgtcttg tgtttgctgc agagtgattc gggggctgac ctagaccagt 3540
ttgcatgatt cttctcttgt gatttggttg cactttagac atttttgtgc cattatattt 3600
gcattatgta tttataattt aaatgatatt taggtttttg gctgagtact ggaataaaca 3660
gtgagcatat ctggtatatg tcattattta ttgttaaatt acatttttaa gctccatgtg 3720
catataaagg ttatgaaaca tatcatggta atgacagatg caagttattt tatttgctta 3780
tttttataat taaagatgcc atagcataat atgaagcctt tggtgaattc cttctaagat 3840
aaaaataata ataaagtgtt acgtttta 3868
<210> 266
<211> 2613
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2613)
<223> SDC4 mRNA
<400> 266
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt 60
cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat 120
cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga 180
tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga 240
tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa 300
ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga 360
ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa 420
caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct 480
ggcagctctg attgtgggtg gcatcgtggg catcctcttt gccgtcttcc tgatcctact 540
gctcatgtac cgtatgaaga agaaggatga aggcagctat gacctgggca agaaacccat 600
ctacaagaaa gcccccacca atgagttcta cgcgtgaagc ttgcttgtgg gcactggctt 660
ggactttagc ggggagggaa gccaggggat tttgaagggt ggacattagg gtagggtgag 720
gtcaacctaa tactgacttg tcagtatctc cagctctgat tacctttgaa gtgttcagaa 780
gagacattgt cttctactgt tctgccaggt tcttcttgag ctttgggcct cagttgccct 840
ggcagaaaaa tggattcaac ttggcctttc tgaaggcaag actgggattg gatcacttct 900
taaacttcca gttaagaatc taggtccgcc ctcaagccca tactgaccat gcctcatcca 960
gagctcctct gaagccaggg ggctaacgga tgttgtgtgg agtcctggct ggaggtcctc 1020
ccccagtggc cttcctccct tcctttcaca gccggtctct ctgccaggaa atgggggaag 1080
gaactagaac cacctgcacc ttgagatgtt tctgtaaatg ggtacttgtg atcacactac 1140
gggaatctct gtggtatata cctggggcca ttctaggctc tttcaagtga cttttggaaa 1200
tcaacctttt ttatttgggg gggaggatgg ggaaaagagc tgagagttta tgctgaaatg 1260
gatttataga atatttgtaa atctattttt agtgtttgtt cgttttttta actgttcatt 1320
cctttgtgca gagtgtatat ctctgcctgg gcaagagtgt ggaggtgccg aggtgtcttc 1380
attctctcgc acatttccac agcacctgct aagtttgtat ttaatggttt ttgtttttgt 1440
ttttgtttgt ttcttgaaaa tgagagaaga gccggagaga tgatttttat taattttttt 1500
tttttttttt tttttttact atttatagct ttagataggg cctcccttcc cctcttcttt 1560
ctttgttctc tttcattaaa ccccttcccc agtttttttt ttatacttta aaccccgctc 1620
ctcatggcct tggccctttc tgaagctgct tcctcttata aaatagcttt tgccgaaaca 1680
tagttttttt ttagcagatc ccaaaatata atgaagggga tggtgggata tttgtgtctg 1740
tgttcttata atatattatt attcttcctt ggttctagaa aaatagataa atatattttt 1800
ttcaggaaat agtgtggtgt ttccagtttg atgttgctgg gtggttgagt gagtgaattt 1860
tcatgtggct gggtgggttt ttgccttttt ctcttgccct gttcctggtg ccttctgatg 1920
gggctggaat agttgaggtg gatggttcta ccctttctgc cttctgtttg ggacccagct 1980
ggtgttcttt ggtttgcttt cttcaggctc tagggctgtg ctatccaata cagtaaccac 2040
atgcggctgt ttaaagttaa gccaattaaa atcacataag attaaaaatt ccttcctcag 2100
ttgcactaac cacgtttcta gaggcgtcac tgtatgtagt tcatggctac tgtactgaca 2160
gcgagagcat gtccatctgt tggacagcac tattctagag aactaaactg gcttaacgag 2220
tcacagcctc agctgtgctg ggacgaccct tgtctccctg ggtagggggg ggggaatggg 2280
ggagggctga tgaggcccca gctggggcct gttgtctggg accctccctc tcctgagagg 2340
ggaggcctgg tggcttagcc tgggcaggtc gtgtctcctc ctgaccccag tggctgcggt 2400
gaggggaacc accctccctt gctgcaccag tggccattag ctcccgtcac cactgcaacc 2460
cagggtccca gctggctggg tcctcttctg cccccagtgc ccttcccctt gggctgtgtt 2520
ggagtgagca cctcctctgt aggcacctct cacactgttg tctgttactg attttttttg 2580
ataaaaagat aataaaacct ggtactttct aaa 2613
<210> 267
<211> 4260
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(4260)
<223> TAGLN mRNA
<400> 267
cgaggagcga gccagtgggg gaggctgaca tcaccacggc ggcagccctt taaacccctc 60
acccagccag cgccccatcc tgtctgtccg aacccagaca caagtcttca ctccttcctg 120
cgagccctga ggaagccttg tgagtgcatt ggctggggct tggagggaag ttgggctgga 180
gctggacagg agcagtgggt gcatttcagg caggctctcc tgaggtccca ggcgccagct 240
ccagctccct ggctagggaa acccaccctc tcagtcagca tgggggccca agctccaggc 300
agggtgggct ggatcactag cgtcctggat ctctctcaga ctgggcagcc ccgggctcat 360
tgaaatgccc cggatgactt ggctagtgca gaggaattga tggaaaccac cggggtgaga 420
gggaggctcc ccatctcagc cagccacatc cacaaggtgt gtgtaagggt gcaggcgccg 480
gccggttagg ccaaggctct actgtctgtt gcccctccag gagaacttcc aaggagcttt 540
ccccagacat ggccaacaag ggtccttcct atggcatgag ccgcgaagtg cagtccaaaa 600
tcgagaagaa gtatgacgag gagctggagg agcggctggt ggagtggatc atagtgcagt 660
gtggccctga tgtgggccgc ccagaccgtg ggcgcttggg cttccaggtc tggctgaaga 720
atggcgtgat tctgagcaag ctggtgaaca gcctgtaccc tgatggctcc aagccggtga 780
aggtgcccga gaacccaccc tccatggtct tcaagcagat ggagcaggtg gctcagttcc 840
tgaaggcggc tgaggactat ggggtcatca agactgacat gttccagact gttgacctct 900
ttgaaggcaa agacatggca gcagtgcaga ggaccctgat ggctttgggc agcttggcag 960
tgaccaagaa tgatgggcac taccgtggag atcccaactg gtttatgaag aaagcgcagg 1020
agcataagag ggaattcaca gagagccagc tgcaggaggg aaagcatgtc attggccttc 1080
agatgggcag caacagaggg gcctcccagg ccggcatgac aggctacgga cgacctcggc 1140
agatcatcag ttagagcgga gagggctagc cctgagcccg gccctccccc agctccttgg 1200
ctgcagccat cccgcttagc ctgcctcacc cacacccgtg tggtaccttc agccctggcc 1260
aagctttgag gctctgtcac tgagcaatgg taactgcacc tgggcagctc ctccctgtgc 1320
ccccagcctc agcccaactt cttacccgaa agcatcactg ccttggcccc tccctcccgg 1380
ctgcccccat cacctctact gtctcctccc tgggctaagc aggggagaag cgggctgggg 1440
gtagcctgga tgtgggccaa gtccactgtc ctccttggcg gcaaaagccc attgaagaag 1500
aaccagccca gcctgccccc tatcttgtcc tggaatattt ttggggttgg aactcaaaaa 1560
aaaaaaaaaa aaatcaatct tttctcaggc ctggctggca gagtttgatt tgccctggtc 1620
acttttgtta tggtttcaga tctgcgcagg ggacaggcag gcatctcggg cttgtatgtg 1680
ttcctggctg ccgtcctctg aaggaccctt catgtgccaa gattccagga cagtcagatt 1740
ctttcagagg aaacaggcca tagaacagga gagtgaatct tggggaccga agggaaaaag 1800
gagccactca gcagcatgca gtggctttgg ggagacagag gaaaggagag attgcgagtg 1860
gcagaattgt ttggaaggtt tttattttgg aaaagctgtg cagaaaaaaa ttcaagaaaa 1920
tgttgctgtg aaaagagaaa aacaaatctt aagcattaaa aaaaattcaa ccaactagct 1980
cagaagaggg gagaaggcca aggttgagag aagagtcaca gcctgtcagg cagatagctg 2040
gcctccggcg ggaaggccat ttccctgagc acttgcagag gaagacaggg tggtggcagg 2100
actggagtgg cagtggctcc caaggctctc tcctccaaca tgtgcatctg ccatctgctc 2160
tgcagtcctg ccgcaggatt ccctagtgaa gcagctcagg cctgggggag ccgtgtgtat 2220
cccagctgtg ccggcagcat cataccaatc gtgggggtgg tgaaggagcc aggggttcat 2280
tcatggttgg tttctgatca ggcatcttgg gaatggataa tggaggcagc cgctttcagg 2340
acaggcatgt ccaggggctc ctcccagcct ctaccccgaa gtcctcttcc caagtgaccc 2400
cagtgatgtt tccattgaga tgcgctcctg gctatggcag gcaccttctc aacttatatg 2460
tgggaagggg tcccccatgc ttgggggacc taggcagctg gcttggccca agagagatga 2520
ggatggaggc caaaccaaag gggggcgcca atcccctgtc caacaccttc tcaccaaaag 2580
ctcccgtttg gctggaggca gaccctgtgg ctctgaccag acttctctgg cagcaatcct 2640
ccaccatttg tatcttaaga aggccctcac cctctttgag tggagtcaga ggatgcctca 2700
gattccagat gtaagcatca gaactgcttt ctgtcaagag ctccctaatt ttgggaaaga 2760
agagcctgtc ccacactgtc aggccctgag gtcagcagat ctgctcctcc ttcccgtgcg 2820
gtacgtctag gtgctgatga gggcagtcca gggcgctctt gttctgggac aggctccagt 2880
ccccttgctc cagcaggtct ggggcaagga ggtcagaggt ggtgggaggg cccctgctct 2940
ctgtttccac ttcgtctgga tccttgctgc tgcaaagtgg cactgattct agctctgtcc 3000
cttcctcctt ggctttccgg ctccgatggg gccagtggca gggtccactc ctacaaactt 3060
gattggaagc cacattcctc tggctcaaat atacttccag catgtagtaa acagtccaga 3120
agacggtgaa acagcctacc agcaccaggg tctggggccg aggcaagcac ctacgtgagg 3180
cactgtttcc cgaagcctac agcctttctc agcccaggac aatgagctca gaaagtcttt 3240
ttccttctag ggactgcctt tttcacccaa actgttccct ctgccccctc ccccgacaag 3300
gcctgtcctg taagagttag gctagcaggg taggagcaat gctatgaaac cactgctggg 3360
acccaggtct tcccagtcct tcaccccgca ggtcaccctg agaaacacac taagaactcc 3420
atcccccaga caggacagtc ccatctaccc gcagcttgag tcttggccct agtaccttga 3480
gggtgttggg ggtgatggtg taaccatctt cctcaggaat tttcagcccc ggtgggcagg 3540
gcagggcgaa gtcatcgtgc aggtattttc cactcatggc actctctaac agcctgtgga 3600
gaagaaaaga ggtgaggatg ccccactgac tatggttcct ataccatctg ccctcaccca 3660
ttttcctgcc ttacaggtga agacagggaa gccccacagc aaaaaggaga ggcccagact 3720
gtgagttccc agcccggggc tccatctacc ggcttgacgc tggaactggg aagcacagct 3780
ggggttcaga gggcgatggg ctccctaggc ggcccttccc ctgtgactgg ccttccctct 3840
gacacatgcg gctttaccca cctttgtctg tccctgatgt ctactgcact ccacacagag 3900
ccatataggg tcagctgcca ttgccggagg atgccgacct ggaatgactc atcccctagg 3960
gcagcaaggg gcagctcgtg agccacgccc ctctgtcagc catgccagac agcagaggcc 4020
ctgcccgccc tgccacccaa aggggctcag gccacatggt ctgctccagg agctgcctca 4080
ctgtgtccca ctgaccccag gttctgcaga agggcctcac tgggtgccct tagggatgga 4140
aagggttgaa aggctgtact ccaaagcaga gtcttgcttt tctctcccgt attttggggg 4200
ttcagctggg attagaaaaa aatgtctttc caccaaatta aagaaagctt tgaaaaccac 4260
4260
<210> 268
<211> 2444
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2444)
<223> TFPI2 mRNA
<400> 268
attactgaca caaacgctcc ctcagggcgt ccccgtctgg actacaggag aaagtttggg 60
aggcaggttc aacttttcaa cttggcgggg aattcctctc cctcttacac agtttgcagc 120
gcgggggcgg cggggtgaca gtccccgtgc atgaatcagc cacccctcag gctccgcccc 180
ggcgggggtc ggccggacgc tcgccccgca taaagcgggc acccgggccg cctggagcag 240
aaagccgcgc acctcctccc gccaggcgct ttctcggacg ccttgcccag cgggccgccc 300
gaccccctgc accatggacc ccgctcgccc cctggggctg tcgattctgc tgcttttcct 360
gacggaggct gcactgggcg atgctgctca ggagccaaca ggaaataacg cggagatctg 420
tctcctgccc ctagactacg gaccctgccg ggccctactt ctccgttact actacgacag 480
gtacacgcag agctgccgcc agttcctgta cgggggctgc gagggcaacg ccaacaattt 540
ctacacctgg gaggcttgcg acgatgcttg ctggaggata gaaaaagttc ccaaagtttg 600
ccggctgcaa gtgagtgtgg acgaccagtg tgaggggtcc acagaaaagt atttctttaa 660
tctaagttcc atgacatgtg aaaaattctt ttccggtggg tgtcaccgga accggattga 720
gaacaggttt ccagatgaag ctacttgtat gggcttctgc gcaccaaaga aaattccatc 780
attttgctac agtccaaaag atgagggact gtgctctgcc aatgtgactc gctattattt 840
taatccaaga tacagaacct gtgatgcttt cacctatact ggctgtggag ggaatgacaa 900
taactttgtt agcagggagg attgcaaacg tgcatgtgca aaagctttga aaaagaaaaa 960
gaagatgcca aagcttcgct ttgccagtag aatccggaaa attcggaaga agcaatttta 1020
aacattctta atatgtcatc ttgtttgtct ttatggctta tttgccttta tggttgtatc 1080
tgaagaataa tatgacagca tgaggaaaca aatcattggt gatttattca ccagttttta 1140
ttaatacaag tcacttttta aaaaatttgg atttttttat atataactag ctgctattca 1200
aatgtgagtc taccattttt aatttatggt tcaactgttt gtgagactga attcttgcaa 1260
tgcataagat ataaaagcaa atatgactca ctcatttctt ggggtcgtat tcctgatttc 1320
agaagaggat cataactgaa acaacataag acaatataat catgtgcttt taacatattt 1380
gagaataaaa aggactagca aataaaactc attttgcatt taaaagttgg attatatttt 1440
agtcccaaga agacaaagtc gcagattaac aacactttaa aaatattact cccattttat 1500
tgtgttagat tgcagtacaa tgaatgaata aggggattta tttaaaagat cttaactttc 1560
ttgactgatt taaaaagcta atcaatttat taaagccaga aatgttctcc tctgggaaag 1620
caatttctat ctatttatct accaatcccc actcacatgt atatgtttgt gtttacatag 1680
agatagatgg ttttaagggt tttcctattg ttaaattatt tcctaagaca ttgtgggttg 1740
gagaccacta aacttataaa aaaccaagga aagtaaagtt tttcaaatgt ttatactgtt 1800
taaggtgttt atttatataa accatgcatg agaaaccatg cataaattta ataatttaaa 1860
tttcaccagt aaattatcat tgattaaata tggtcatacc aatgaaatag gttttttctt 1920
tctctgtaat aaaacaattt ttctaaattc ttatgttttc atagcaagat taacatattt 1980
aattacaaat taaatatgca aaatgacaaa tgcgtttacc ttttgcttga acaatctttc 2040
atttaaaaat ttatcccagt tattttgaca aataggtata tgcctgagaa ctttgaatga 2100
tgctgaaagc tagaagcaaa ccaggtactc ttcagtcagg gactggttga agattttatg 2160
gatgaggagt tagcaaaata tctatatatg catatcttct gactcccagg atacataaga 2220
aacacagggc ctagaacagt atgaataaac acacatatac acaaacatca cagaagatac 2280
taaagatatt aaaaatgttt acctatagag gtttggagag aacagagggg tggacagttg 2340
tggagataat atttgtgtaa atataactgt gatatagttt ttatcttgga ccatgtaaat 2400
atttgacata attaataatc aaaattaaat aaaaaagaaa aagc 2444
<210> 269
<211> 2741
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(2741)
<223> TGFB1 mRNA
<400> 269
acctccctcc gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc 60
cgtccggggc acccccccgg ctctgagccg cccgcggggc cggcctcggc ccggagcgga 120
ggaaggagtc gccgaggagc agcctgaggc cccagagtct gagacgagcc gccgccgccc 180
ccgccactgc ggggaggagg gggaggagga gcgggaggag ggacgagctg gtcgggagaa 240
gaggaaaaaa acttttgaga cttttccgtt gccgctggga gccggaggcg cggggacctc 300
ttggcgcgac gctgccccgc gaggaggcag gacttgggga ccccagaccg cctccctttg 360
ccgccgggga cgcttgctcc ctccctgccc cctacacggc gtccctcagg cgcccccatt 420
ccggaccagc cctcgggagt cgccgacccg gcctcccgca aagacttttc cccagacctc 480
gggcgcaccc cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc ccgcgcatcc 540
tagacccttt ctcctccagg agacggatct ctctccgacc tgccacagat cccctattca 600
agaccaccca ccttctggta ccagatcgcg cccatctagg ttatttccgt gggatactga 660
gacacccccg gtccaagcct cccctccacc actgcgccct tctccctgag gacctcagct 720
ttccctcgag gccctcctac cttttgccgg gagaccccca gcccctgcag gggcggggcc 780
tccccaccac accagccctg ttcgcgctct cggcagtgcc ggggggcgcc gcctccccca 840
tgccgccctc cgggctgcgg ctgctgccgc tgctgctacc gctgctgtgg ctactggtgc 900
tgacgcctgg ccggccggcc gcgggactat ccacctgcaa gactatcgac atggagctgg 960
tgaagcggaa gcgcatcgag gccatccgcg gccagatcct gtccaagctg cggctcgcca 1020
gccccccgag ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg ctcgccctgt 1080
acaacagcac ccgcgaccgg gtggccgggg agagtgcaga accggagccc gagcctgagg 1140
ccgactacta cgccaaggag gtcacccgcg tgctaatggt ggaaacccac aacgaaatct 1200
atgacaagtt caagcagagt acacacagca tatatatgtt cttcaacaca tcagagctcc 1260
gagaagcggt acctgaaccc gtgttgctct cccgggcaga gctgcgtctg ctgaggctca 1320
agttaaaagt ggagcagcac gtggagctgt accagaaata cagcaacaat tcctggcgat 1380
acctcagcaa ccggctgctg gcacccagcg actcgccaga gtggttatct tttgatgtca 1440
ccggagttgt gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt cgccttagcg 1500
cccactgctc ctgtgacagc agggataaca cactgcaagt ggacatcaac gggttcacta 1560
ccggccgccg aggtgacctg gccaccattc atggcatgaa ccggcctttc ctgcttctca 1620
tggccacccc gctggagagg gcccagcatc tgcaaagctc ccggcaccgc cgagccctgg 1680
acaccaacta ttgcttcagc tccacggaga agaactgctg cgtgcggcag ctgtacattg 1740
acttccgcaa ggacctcggc tggaagtgga tccacgagcc caagggctac catgccaact 1800
tctgcctcgg gccctgcccc tacatttgga gcctggacac gcagtacagc aaggtcctgg 1860
ccctgtacaa ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg ccgcaggcgc 1920
tggagccgct gcccatcgtg tactacgtgg gccgcaagcc caaggtggag cagctgtcca 1980
acatgatcgt gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc cccgccccgg 2040
caggcccggc cccaccccgc cccgcccccg ctgccttgcc catgggggct gtatttaagg 2100
acacccgtgc cccaagccca cctggggccc cattaaagat ggagagagga ctgcggatct 2160
ctgtgtcatt gggcgcctgc ctggggtctc catccctgac gttcccccac tcccactccc 2220
tctctctccc tctctgcctc ctcctgcctg tctgcactat tcctttgccc ggcatcaagg 2280
cacaggggac cagtggggaa cactactgta gttagatcta tttattgagc accttgggca 2340
ctgttgaagt gccttacatt aatgaactca ttcagtcacc atagcaacac tctgagatgc 2400
agggactctg ataacaccca ttttaaaggt gaggaaacaa gcccagagag gttaagggag 2460
gagttcctgc ccaccaggaa cctgctttag tgggggatag tgaagaagac aataaaagat 2520
agtagttcag gccaggcggg gtggctcacg cctgtaatcc tagcactttt gggaggcaga 2580
gatgggagga ttacttgaat ccaggcattt gagaccagcc tgggtaacat agtgagaccc 2640
tatctctaca aaacactttt aaaaaatgta cacctgtggt cccagctact ctggaggcta 2700
aggtgggagg atcacttgat cctgggaggt caaggctgca g 2741
<210> 270
<211> 6339
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6339)
<223> TGFBR3 mRNA
<400> 270
aatcgagggt ttcggggacg ccgagcggca ctttcctctt cccagcgagt gaaggagggc 60
agtcggcggc tctcgcgccc cggccacttt ccctgcgcga ttcccggagc tccctgcagg 120
aggtgagagt ccccagcggg tccggatggc gtagttttgc cgcggcgcag cagctgccgg 180
agctcgccgc cgccgagcgc tgggcgggga aacttgccgc cgctttcctc caacttgctg 240
cgggtggatc tccgctggac acaccgcctc cgaggcagtt tgaaaattgc aaggagggac 300
tttaagacta cttctgattt gcaaagattg tctgtgctct gagcaggctg aagtgactgg 360
acgagacgca ctgttggaga aataaaaatg acttcccatt atgtgattgc catctttgcc 420
ctgatgagct cctgtttagc cactgcaggt ccagagcctg gtgcactgtg tgaactgtca 480
cctgtcagtg cctcccatcc tgtccaggcc ttgatggaga gcttcactgt tttgtcaggc 540
tgtgccagca gaggcacaac tgggctgcca caggaggtgc atgtcctgaa tctccgcact 600
gcaggccagg ggcctggcca gctacagaga gaggtcacac ttcacctgaa tcccatctcc 660
tcagtccaca tccaccacaa gtctgttgtg ttcctgctca actccccaca ccccctggtg 720
tggcatctga agacagagag acttgccact ggggtctcca gactgttttt ggtgtctgag 780
ggttctgtgg tccagttttc atcagcaaac ttctccttga cagcagaaac agaagaaagg 840
aacttccccc atggaaatga acatctgtta aattgggccc gaaaagagta tggagcagtt 900
acttcattca ccgaactcaa gatagcaaga aacatttata ttaaagtggg ggaagatcaa 960
gtgttccctc caaagtgcaa catagggaag aattttctct cactcaatta ccttgctgag 1020
taccttcaac ccaaagcagc agaagggtgt gtgatgtcca gccagcccca gaatgaggaa 1080
gtacacatca tcgagctaat cacccccaac tctaacccct acagtgcttt ccaggtggat 1140
ataacaattg atataagacc ttctcaagag gatcttgaag tggtcaaaaa tctcatcctg 1200
atcttgaagt gcaaaaagtc tgtcaactgg gtgatcaaat cttttgatgt taagggaagc 1260
ctgaaaatta ttgctcctaa cagtattggc tttggaaaag agagtgaaag atctatgaca 1320
atgaccaaat caataagaga tgacattcct tcaacccaag ggaatctggt gaagtgggct 1380
ttggacaatg gctatagtcc aataacttca tacacaatgg ctcctgtggc taatagattt 1440
catcttcggc ttgaaaataa tgcagaggag atgggagatg aggaagtcca cactattcct 1500
cctgagctac ggatcctgct ggaccctggt gccctgcctg ccctgcagaa cccgcccatc 1560
cggggagggg aaggccaaaa tggaggcctt ccgtttcctt tcccagatat ttccaggaga 1620
gtctggaatg aagagggaga agatgggctc cctcggccaa aggaccctgt cattcccagc 1680
atacaactgt ttcctggtct cagagagcca gaagaggtgc aagggagcgt ggatattgcc 1740
ctgtctgtca aatgtgacaa tgagaagatg atcgtggctg tagaaaaaga ttcttttcag 1800
gccagtggct actcggggat ggacgtcacc ctgttggatc ctacctgcaa ggccaagatg 1860
aatggcacac actttgtttt ggagtctcct ctgaatggct gcggtactcg gccccggtgg 1920
tcagcccttg atggtgtggt ctactataac tccattgtga tacaggttcc agcccttggg 1980
gacagtagtg gttggccaga tggttatgaa gatctggagt caggtgataa tggatttccg 2040
ggagatatgg atgaaggaga tgcttccctg ttcacccgac ctgaaatcgt ggtgtttaat 2100
tgcagccttc agcaggtgag gaaccccagc agcttccagg aacagcccca cggaaacatc 2160
accttcaaca tggagctata caacactgac ctctttttgg tgccctccca gggcgtcttc 2220
tctgtgccag agaatggaca cgtttatgtt gaggtatctg ttactaaggc tgaacaagaa 2280
ctgggatttg ccatccaaac gtgctttatc tctccatatt cgaaccctga taggatgtct 2340
cattacacca ttattgagaa tatttgtcct aaagatgaat ctgtgaaatt ctacagtccc 2400
aagagagtgc actttcctat cccgcaagct gacatggata agaagcgatt cagctttgtc 2460
ttcaagcctg tcttcaacac ctcactgctc tttctacagt gtgagctgac gctgtgtacg 2520
aagatggaga agcaccccca gaagttgcct aagtgtgtgc ctcctgacga agcctgcacc 2580
tcgctggacg cctcgataat ctgggccatg atgcagaata agaagacgtt cactaagccc 2640
cttgctgtga tccaccatga agcagaatct aaagaaaaag gtccaagcat gaaggaacca 2700
aatccaattt ctccaccaat tttccatggt ctggacaccc taaccgtgat gggcattgcg 2760
tttgcagcct ttgtgatcgg agcactcctg acgggggcct tgtggtacat ctattctcac 2820
acaggggaga cagcaggaag gcagcaagtc cccacctccc cgccagcctc ggaaaacagc 2880
agtgctgccc acagcatcgg cagcacgcag agcacgcctt gctccagcag cagcacggcc 2940
tagcccaacc cagcccaacc cggcccaacc cagcccagcc cagctcagct cagctactgc 3000
caagggcagg accaatggct gagcctcgtg tccagactca gagggctgga ttttggttcc 3060
cttgtaaaga cagagtgaat ttcagtataa agatcacccg ttgtattcac cccacaccca 3120
gggctagtat aaacatgacc ctgggcttct gtaccacact agaattcatg tgagaaagct 3180
aaaatggtgg tcttctccac cagcccctca caggcttggg ggttttcaat gtgaaacaca 3240
tgccagtttt taaaatgctg ctttgtccag gtgagaacat ccataatttg gggccctgag 3300
ttttacccag actcaaggag ttggtaaagg gttaatagcc agatagtaga accagtgagg 3360
agatgcggcc aaagattctt tatatctgaa ccaagatgta aaacaagaaa tgctttgagg 3420
ctttctaagc gatcctcctg tctaatttgc acctttgtct ggatgcacac ttctgacctt 3480
gctgccacaa cctgtggggt ctgatgtgtc ccttgatggg tgctgccctc agggactgca 3540
ccctgacaag tgttaaggca acattccttt cttgtgccct gggccaaaac caatgctgat 3600
gaccttatca gcttcctgtt tcttcccata cttgcataca ccactgcaaa atgtcttaat 3660
gcaaattttg tatttcttac aggcctacag aaattgaaaa tgaccaaaat caggaaccac 3720
agatttgtgc ccattcctaa tattttgttc tgcaaattaa tgtataattt gaggtgaaat 3780
tcagttataa agtcaaggac gaatttgcac agtgatatat ttctatgtgt atgcaagtac 3840
aagtatataa tatgtcacct ggcacattca ttttctcagt tgaagaagag aaaatttgaa 3900
aatgtcctta tgcttttaga gttgcaactt aagtatattt ggtagggtga gtgtttccac 3960
tcaaaatatg tcaacttaaa aaaaaatagg ccctttcata aaaaccaaac tgtagcaaga 4020
tgcaaatgca tggcaaatcc tgtcggtctc cagttggtta tctgaatagt gtcaccaatt 4080
ccaccaagac agtgctgaga ttggaaaagg gcactcattt ggattgcctt acttctcttg 4140
ccttaaatat atcccatata tttaatatgt caaaaagggc ttgaggtgaa tttcattaaa 4200
tggaataata tgatgccact ttgcagctaa aataagctca gtgatacctc cttgttaaaa 4260
aaaaaaaaaa aaaaaaagaa tgccaggggg gaattatcat gctaaattat tttactgctg 4320
aagatagctt cattgcaaat tattcttttt ccagaatttc ccccaaacaa cttagaattc 4380
cataagtaga acaagataga ttctaccccc aaaatattca taagcaaatc ccactgccct 4440
taaaataagg aagttatgcc tggttgtctg tgaatggaac ctcagtaggt aatcctgatg 4500
aagcttaaaa ccttagggca gtgtctacat gggaaacaag tatgtggaaa ttgacaatca 4560
tttttaccaa atcgttgagt aataatatga cttacctgat agatatacac attcaataag 4620
gaacattttt ttttttcaat aaggaacatt ttaactaaaa cattacttta gggctgagat 4680
ttccaggcta tctacattga tctactgaaa aatttctaga tttccatata caaacgaaga 4740
agacatgagt ttagagaatt tttttccttt aatttttttt taacagaagg gtatcagagt 4800
ggaggaccta gattacgcta cctgtgtttg aaaatattgc gctttgccta accttcggtg 4860
gaatgtattg tttcagcata ttctatgtat aaaaaagttt aaagatgtct tcaaagaaga 4920
ctagagtctt taagtcactt atagctatat tttactacaa aatttgtgta taaagatata 4980
tttaagtgtt ttagataaat ttaagttact ccatatgaaa tgtttaattt cagctactgt 5040
gaattctttc gatcagtcct ttgctttttt aaaaaatctt ttccatcgtg ttaaaaagaa 5100
aattagctat taggagatat taaaagattg atgtcttaga aggacagggt taaaaccttc 5160
tgtaatatat ttaaatatat atttttaaga gagatgctac attgccaatg attttataaa 5220
taatttaaaa ttaatttaca aatttataga tgcaaaccaa aagatctttt taaaagagag 5280
agagaggaaa aaaatcacct tttatttgtt tgggtctcat tgtcagaatt attattcaga 5340
tcaagaaatc tgtgtcgata aaacctaatc tcatattgga gagtgaatgt cgttaagtat 5400
ttctgaaatg tttctaaaaa atgaacatga aaaaaataag gtattttctc cctagcttct 5460
cattacagta tttctaattg cttcacactt tacagtttta atacaaagta caagctctac 5520
ttttataacg tgtactacaa gtttctttaa aagtattgtt gtatttcagc tgaactcttg 5580
tatctgcagt cttttgttat ttctgcaggc tacaccctta atttgcagag gccattttgt 5640
tgtttgtttg atgctgaagc tgttgttaaa atgccccaaa ctccaaggca gattgtctgt 5700
ataatacgct atagcttttc accatgtggt gtttaccagc tgttactctg tattttaaaa 5760
agccagagat ttcttctgtc taaactgttt ctatagcatt ttctaaacaa aaaaaatggt 5820
ttttttcttt gccttgtaat aagattgtaa atccatttcc tgcttgtgtt cttagtgggc 5880
atgattgtga gtgtgtgtgg ggtgctcaca cgcgtgccag tctttttgta ctgtaactac 5940
ctcatggttt gaatgatgat tgtactgctg gttgtgttaa cagagcacat tttgttgggt 6000
gagtcctatg tgattttttt catgtttgtt ttatctgggg gttgttcatg aaactgacag 6060
atgtttttct aaaaaggact attatcagtt tccaaataca atacttctct cttctggttt 6120
ttcctgaatg agcctgattt tgttgctggt tttcatcatc tatgagggta aaacgagtac 6180
ccttaaaatc cctgtggcca gtttgaacac ccctgttgta ttcttttctc tgttcagtgt 6240
gtcagctatt ttgtgaagat gcttagatgt atagttttga taaccacagt tttaaatctt 6300
ttatctgtgc ataataaaaa gatatatatc agttattaa 6339
<210> 271
<211> 769
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(769)
<223> TIMP1 mRNA
<400> 271
gccatcgccg cagatccagc gcccagagag acaccagaga acccaccatg gccccctttg 60
agcccctggc ttctggcatc ctgttgttgc tgtggctgat agcccccagc agggcctgca 120
cctgtgtccc accccaccca cagacggcct tctgcaattc cgacctcgtc atcagggcca 180
agttcgtggg gacaccagaa gtcaaccaga ccaccttata ccagcgttat gagatcaaga 240
tgaccaagat gtataaaggg ttccaagcct taggggatgc cgctgacatc cggttcgtct 300
acacccccgc catggagagt gtctgcggat acttccacag gtcccacaac cgcagcgagg 360
agtttctcat tgctggaaaa ctgcaggatg gactcttgca catcactacc tgcagttttg 420
tggctccctg gaacagcctg agcttagctc agcgccgggg cttcaccaag acctacactg 480
ttggctgtga ggaatgcaca gtgtttccct gtttatccat cccctgcaaa ctgcagagtg 540
gcactcattg cttgtggacg gaccagctcc tccaaggctc tgaaaagggc ttccagtccc 600
gtcaccttgc ctgcctgcct cgggagccag ggctgtgcac ctggcagtcc ctgcggtccc 660
agatagcctg aatcctgccc ggagtggaag ctgaagcctg cacagtgtcc accctgttcc 720
cactcccatc tttcttccgg acaatgaaat aaagagttac cacccagca 769
<210> 272
<211> 1876
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1876)
<223> TMEM158 mRNA
<400> 272
ggggaatcct gctctgggat agcacccggc cccgcagagc agcgcggcag cccaagggcc 60
ccggcgccgg gggcggcggg gaaccccaaa cgcaaccggg tctggaggga tccccgcgcc 120
gagccagccg ccgtcaccgc ctccgcgccg cccctgcggg cttggcaggc gcccggcgcg 180
cccgcactgc gcccggccgc cggctcccgc ggtcccaccg tgagctcgcc ggcccgtcgc 240
ccgctcgcca tgcaaccgcc gccggcctcg cgcgcgtagg cgcccgccgc aggccatgct 300
gcccctgctc gccgcgctcc tggccgccgc ctgcccgctg ccgcccgtcc gcggcggggc 360
cgcggacgcg cccggcctcc tcggggtgcc ctccaatgct tcagtcaacg cgtcctccgc 420
ggacgagccc atcgccccgc ggctgctggc ctcggcggcc cccgggcccc ccgagcgccc 480
gggcccggag gaggcggcgg cggcggcggc gccgtgcaac atcagcgtgc agcggcagat 540
gctgagctcg ctgctcgtgc gctggggccg cccgcggggc ttccagtgcg acctactgct 600
cttctccacc aacgcgcacg gccgcgcttt cttcgccgcc gccttccacc gcgtcgggcc 660
gccgctgctc atcgagcacc tggggctggc ggcgggcggc gcgcagcagg acctgcgcct 720
ctgcgtgggc tgcggctggg tgcgcggtcg ccgcaccggc cgcctccggc ccgccgccgc 780
ccccagcgcc gccgccgcca ccgccggggc gcccaccgcg ctgccagcct accccgcggc 840
cgagccgccc gggccgctgt ggctgcaggg cgagccgctg catttctgct gcctagactt 900
cagcctggag gagctgcagg gcgagccggg ctggcggctg aaccgtaagc ccattgagtc 960
cacgctggtg gcctgcttca tgaccctggt catcgtggtg tggagcgtgg ccgccctcat 1020
ctggccggtg cccatcatcg ccggcttcct gcccaacggc atggaacagc gccggaccac 1080
cgccagcacc accgcagcca cccccgccgc agtgcccgca gggaccaccg cagccgccgc 1140
cgccgccgcc gctgccgccg ccgccgcggc cgtcacttcg ggggtggcga ccaagtgacc 1200
cgctccgctc ctccctgtgt ccgtcctgtg tccgcgcgcg cgggtgcctt tcccgccgga 1260
gactcggccg gtgtgcttcg tgctgtagtt atcgttagtt cctcttcccg agatggggcc 1320
gccgagagac cccagcgcct ttgaaaagca aggtttgtgc tgcgcttcca gttccgaaaa 1380
gcagatgttt aagcccttgg actgagggtg ggatcgcagc tccgaagacg gagaggaggg 1440
aaatggggcc ctttcccctc tattgcatcc ccctgcccga ctccttcccc gcacccacgt 1500
gccctagatt catggcagaa aatgaccaaa tcctgtgtat ttgttttata tatttaataa 1560
ctgttttaaa tgaaagtttt agtaaaaaaa atacaaaaca aaaagattaa attgctattg 1620
ctgtagtaag agaagctctt tgtatctgaa catagttgta tttgaaattt gtggtttttt 1680
aatttattta aaattggggg gagggcatgg gaaggattta acaccgatat attgttaccg 1740
ctgaaaatga actttatgaa ccttttccaa gttgatctat ccagtgacgt ggcctggtgg 1800
gcgtttcttc ttgtacttat gtggtttttt ggcttttaat acagacattt tcctccagaa 1860
aaaaaaaaaa aaaaaa 1876
<210> 273
<211> 1422
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1422)
<223> TNFAIP6 mRNA
<400> 273
agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc 60
actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact 120
caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc 180
ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag 240
gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga 300
aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc 360
attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc 420
cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt 480
ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac 540
gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg 600
agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata 660
tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca 720
gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg 780
acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa 840
ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc 900
cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt 960
ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa 1020
agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa 1080
cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt 1140
cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa 1200
ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata 1260
aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata 1320
ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg 1380
tcattttcat aaatattgtt gcaataaata tccttgaaca ca 1422
<210> 274
<211> 3677
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(3677)
<223> VEGFA mRNA
<400> 274
tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag 60
cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg 120
ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa 180
catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca 240
cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt 300
ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga 360
gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg 420
agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc 480
cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac 540
cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg 600
gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt 660
ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc 720
gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag 780
ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg 840
aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc 900
gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc 960
gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc 1020
ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg 1080
ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg 1140
cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca 1200
atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag 1260
ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt 1320
gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc 1380
cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa 1440
gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag 1500
cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg 1560
ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg 1620
tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag 1680
gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc 1740
gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac 1800
tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag 1860
aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt 1920
gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc 1980
tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat 2040
tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat 2100
atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata 2160
tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac 2220
tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag 2280
gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct 2340
cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa 2400
caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga 2460
cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg 2520
acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc 2580
actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt 2640
gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc 2700
agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg 2760
gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc 2820
aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct 2880
tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga 2940
aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa 3000
acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt 3060
caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg 3120
tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc 3180
ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc 3240
cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg 3300
gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat 3360
aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa 3420
ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg 3480
gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc 3540
tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa 3600
tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca 3660
aaaaaaaaaa aaaaaaa 3677
<210> 275
<211> 6194
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(6194)
<223> WNT5A mRNA
<400> 275
actaactcgc ggctgcagga tcagcgtctg gaagcagacg tttcggctac agacccagag 60
aggaggagct ggagatcagg aggcgtgagc cgccaagagt ttgcagaatc tgtggtgtga 120
atgaactggg ggcacctggg cgcacagatc gccccccttc ccccgccccg ggccacagtt 180
gagtagtggt acattttttt caccctcttg tgaagaattt ctttttatta ttatttgtcg 240
taaggtcttt tgcacaatca cgcccacatt tggggttgga aagccctaat taccgccgtc 300
gctgatggac gttggaaacg gagcgcctct ccgtggaaca gttgcctgcg cgccctcgcc 360
ggaccggcgg ctccctagtt gcgccccgac caggccctgc ccttgctgcc ggctcgcgcg 420
cgtccgcgcc ccctccattc ctgggcgcat cccagctctg ccccaactcg ggagtccagg 480
cccgggcgcc agtgcccgct tcagctccgg ttcactgcgc ccgccggacg cgcgccggag 540
gactccgcag ccctgctcct gaccgtcccc ccaggcttaa cccggtcgct ccgctcggat 600
tcctcggctg cgctcgctcg ggtggcgact tcctccccgc gccccctccc cctcgccatg 660
aagaagtcca ttggaatatt aagcccagga gttgctttgg ggatggctgg aagtgcaatg 720
tcttccaagt tcttcctagt ggctttggcc atatttttct ccttcgccca ggttgtaatt 780
gaagccaatt cttggtggtc gctaggtatg aataaccctg ttcagatgtc agaagtatat 840
attataggag cacagcctct ctgcagccaa ctggcaggac tttctcaagg acagaagaaa 900
ctgtgccact tgtatcagga ccacatgcag tacatcggag aaggcgcgaa gacaggcatc 960
aaagaatgcc agtatcaatt ccgacatcga aggtggaact gcagcactgt ggataacacc 1020
tctgtttttg gcagggtgat gcagataggc agccgcgaga cggccttcac atacgcggtg 1080
agcgcagcag gggtggtgaa cgccatgagc cgggcgtgcc gcgagggcga gctgtccacc 1140
tgcggctgca gccgcgccgc gcgccccaag gacctgccgc gggactggct ctggggcggc 1200
tgcggcgaca acatcgacta tggctaccgc tttgccaagg agttcgtgga cgcccgcgag 1260
cgggagcgca tccacgccaa gggctcctac gagagtgctc gcatcctcat gaacctgcac 1320
aacaacgagg ccggccgcag gacggtgtac aacctggctg atgtggcctg caagtgccat 1380
ggggtgtccg gctcatgtag cctgaagaca tgctggctgc agctggcaga cttccgcaag 1440
gtgggtgatg ccctgaagga gaagtacgac agcgcggcgg ccatgcggct caacagccgg 1500
ggcaagttgg tacaggtcaa cagccgcttc aactcgccca ccacacaaga cctggtctac 1560
atcgacccca gccctgacta ctgcgtgcgc aatgagagca ccggctcgct gggcacgcag 1620
ggccgcctgt gcaacaagac gtcggagggc atggatggct gcgagctcat gtgctgcggc 1680
cgtggctacg accagttcaa gaccgtgcag acggagcgct gccactgcaa gttccactgg 1740
tgctgctacg tcaagtgcaa gaagtgcacg gagatcgtgg accagtttgt gtgcaagtag 1800
tgggtgccac ccagcactca gccccgctcc caggacccgc ttatttatag aaagtacagt 1860
gattctggtt tttggttttt agaaatattt tttatttttc cccaagaatt gcaaccggaa 1920
ccattttttt tcctgttacc atctaagaac tctgtggttt attattaata ttataattat 1980
tatttggcaa taatgggggt gggaaccaag aaaaatattt attttgtgga tctttgaaaa 2040
ggtaatacaa gacttctttt gatagtatag aatgaagggg aaataacaca taccctaact 2100
tagctgtgtg gacatggtac acatccagaa ggtaaagaaa tacattttct ttttctcaaa 2160
tatgccatca tatgggatgg gtaggttcca gttgaaagag ggtggtagaa atctattcac 2220
aattcagctt ctatgaccaa aatgagttgt aaattctctg gtgcaagata aaaggtcttg 2280
ggaaaacaaa acaaaacaaa acaaacctcc cttccccagc agggctgcta gcttgctttc 2340
tgcattttca aaatgataat ttacaatgga aggacaagaa tgtcatattc tcaaggaaaa 2400
aaggtatatc acatgtctca ttctcctcaa atattccatt tgcagacaga ccgtcatatt 2460
ctaatagctc atgaaatttg ggcagcaggg aggaaagtcc ccagaaatta aaaaatttaa 2520
aactcttatg tcaagatgtt gatttgaagc tgttataaga attaggattc cagattgtaa 2580
aaagatcccc aaatgattct ggacactaga tttttttgtt tggggaggtt ggcttgaaca 2640
taaatgaaaa tatcctgtta ttttcttagg gatacttggt tagtaaatta taatagtaaa 2700
aataatacat gaatcccatt cacaggttct cagcccaagc aacaaggtaa ttgcgtgcca 2760
ttcagcactg caccagagca gacaacctat ttgaggaaaa acagtgaaat ccaccttcct 2820
cttcacactg agccctctct gattcctccg tgttgtgatg tgatgctggc cacgtttcca 2880
aacggcagct ccactgggtc ccctttggtt gtaggacagg aaatgaaaca ttaggagctc 2940
tgcttggaaa acagttcact acttagggat ttttgtttcc taaaactttt attttgagga 3000
gcagtagttt tctatgtttt aatgacagaa cttggctaat ggaattcaca gaggtgttgc 3060
agcgtatcac tgttatgatc ctgtgtttag attatccact catgcttctc ctattgtact 3120
gcaggtgtac cttaaaactg ttcccagtgt acttgaacag ttgcatttat aaggggggaa 3180
atgtggttta atggtgcctg atatctcaaa gtcttttgta cataacatat atatatatat 3240
acatatatat aaatataaat ataaatatat ctcattgcag ccagtgattt agatttacag 3300
tttactctgg ggttatttct ctgtctagag cattgttgtc cttcactgca gtccagttgg 3360
gattattcca aaagtttttt gagtcttgag cttgggctgt ggccctgctg tgatcatacc 3420
ttgagcacga cgaagcaacc ttgtttctga ggaagcttga gttctgactc actgaaatgc 3480
gtgttgggtt gaagatatct tttttctttt ctgcctcacc cctttgtctc caacctccat 3540
ttctgttcac tttgtggaga gggcattact tgttcgttat agacatggac gttaagagat 3600
attcaaaact cagaagcatc agcaatgttt ctcttttctt agttcattct gcagaatgga 3660
aacccatgcc tattagaaat gacagtactt attaattgag tccctaagga atattcagcc 3720
cactacatag atagcttttt tttttttttt tttaataagg acacctcttt ccaaacagtg 3780
ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat 3840
ctttcatacc ccccttaggc aggttggctt tcatatcacc tcagccaact gtggctctta 3900
atttattgca taatgatatt cacatcccct cagttgcagt gaattgtgag caaaagatct 3960
tgaaagcaaa aagcactaat tagtttaaaa tgtcactttt ttggttttta ttatacaaaa 4020
accatgaagt acttttttta tttgctaaat cagattgttc ctttttagtg actcatgttt 4080
atgaagagag ttgagtttaa caatcctagc ttttaaaaga aactatttaa tgtaaaatat 4140
tctacatgtc attcagatat tatgtatatc ttctagcctt tattctgtac ttttaatgta 4200
catatttctg tcttgcgtga tttgtatatt tcactggttt aaaaaacaaa catcgaaagg 4260
cttatgccaa atggaagata gaatataaaa taaaacgtta cttgtatatt ggtaagtggt 4320
ttcaattgtc cttcagataa ttcatgtgga gatttttgga gaaaccatga cggatagttt 4380
aggatgacta catgtcaaag taataaaaga gtggtgaatt ttaccaaaac caagctattt 4440
ggaagcttca aaaggtttct atatgtaatg gaacaaaagg ggaattctct tttcctatat 4500
atgttcctta caaaaaaaaa aaaaaaagaa atcaagcaga tggcttaaag ctggttatag 4560
gattgctcac attcttttag cattatgcat gtaacttaat tgttttagag cgtgttgctg 4620
ttgtaacatc ccagagaaga atgaaaaggc acatgctttt atccgtgacc agatttttag 4680
tccaaaaaaa tgtatttttt tgtgtgttta ccactgcaac tattgcacct ctctatttga 4740
atttactgtg gaccatgtgt ggtgtctcta tgccctttga aagcagtttt tataaaaaga 4800
aagcccgggt ctgcagagaa tgaaaactgg ttggaaacta aaggttcatt gtgttaagtg 4860
caattaatac aagttattgt gcttttcaaa aatgtacacg gaaatctgga cagtgctcca 4920
cagattgata cattagcctt tgctttttct ctttccggat aaccttgtaa catattgaaa 4980
ccttttaagg atgccaagaa tgcattattc cacaaaaaaa cagcagacca acatatagag 5040
tgtttaaaat agcatttctg ggcaaattca aactcttgtg gttctaggac tcacatctgt 5100
ttcagttttt cctcagttgt atattgacca gtgttcttta ttgcaaaaac atatacccga 5160
tttagcagtg tcagcgtatt ttttcttctc atcctggagc gtattcaaga tcttcccaat 5220
acaagaaaat taataaaaaa tttatatata ggcagcagca aaagagccat gttcaaaata 5280
gtcattatgg gctcaaatag aaagaagact tttaagtttt aatccagttt atctgttgag 5340
ttctgtgagc tactgacctc ctgagactgg cactgtgtaa gttttagttg cctaccctag 5400
ctcttttctc gtacaatttt gccaatacca agtttcaatt tgtttttaca aaacattatt 5460
caagccacta gaattatcaa atatgacgct atagcagagt aaatactctg aataagagac 5520
cggtactagc taactccaag agatcgttag cagcatcagt ccacaaacac ttagtggccc 5580
acaatatata gagagataga aaaggtagtt ataacttgaa gcatgtattt aatgcaaata 5640
ggcacgaagg cacaggtcta aaatactaca ttgtcactgt aagctatact tttaaaatat 5700
ttattttttt taaagtattt tctagtcttt tctctctctg tggaatggtg aaagagagat 5760
gccgtgtttt gaaagtaaga tgatgaaatg aatttttaat tcaagaaaca ttcagaaaca 5820
taggaattaa aacttagaga aatgatctaa tttccctgtt cacacaaact ttacacttta 5880
atctgatgat tggatatttt attttagtga aacatcatct tgttagctaa ctttaaaaaa 5940
tggatgtaga atgattaaag gttggtatga ttttttttta atgtatcagt ttgaacctag 6000
aatattgaat taaaatgctg tctcagtatt ttaaaagcaa aaaaggaatg gaggaaaatt 6060
gcatcttaga ccatttttat atgcagtgta caatttgctg ggctagaaat gagataaaga 6120
ttatttattt ttgttcatat cttgtacttt tctattaaaa tcattttatg aaatccaaaa 6180
aaaaaaaaaa aaaa 6194
<210> 276
<211> 1309
<212> RNA
<213> Homo sapiens
<220>
<221> mRNA
<222> (1)..(1309)
<223> GAPDH mRNA
<400> 276
gctctctgct cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc cagccgagcc 60
acatcgctca gacaccatgg ggaaggtgaa ggtcggagtc aacggatttg gtcgtattgg 120
gcgcctggtc accagggctg cttttaactc tggtaaagtg gatattgttg ccatcaatga 180
ccccttcatt gacctcaact acatggttta catgttccaa tatgattcca cccatggcaa 240
attccatggc accgtcaagg ctgagaacgg gaagcttgtc atcaatggaa atcccatcac 300
catcttccag gagcgagatc cctccaaaat caagtggggc gatgctggcg ctgagtacgt 360
cgtggagtcc actggcgtct tcaccaccat ggagaaggct ggggctcatt tgcagggggg 420
agccaaaagg gtcatcatct ctgccccctc tgctgatgcc cccatgttcg tcatgggtgt 480
gaaccatgag aagtatgaca acagcctcaa gatcatcagc aatgcctcct gcaccaccaa 540
ctgcttagca cccctggcca aggtcatcca tgacaacttt ggtatcgtgg aaggactcat 600
gaccacagtc catgccatca ctgccaccca gaagactgtg gatggcccct ccgggaaact 660
gtggcgtgat ggccgcgggg ctctccagaa catcatccct gcctctactg gcgctgccaa 720
ggctgtgggc aaggtcatcc ctgagctgaa cgggaagctc actggcatgg ccttccgtgt 780
ccccactgcc aacgtgtcag tggtggacct gacctgccgt ctagaaaaac ctgccaaata 840
tgatgacatc aagaaggtgg tgaagcaggc gtcggagggc cccctcaagg gcatcctggg 900
ctacactgag caccaggtgg tctcctctga cttcaacagc gacacccact cctccacctt 960
tgacgctggg gctggcattg ccctcaacga ccactttgtc aagctcattt cctggtatga 1020
caacgaattt ggctacagca acagggtggt ggacctcatg gcccacatgg cctccaagga 1080
gtaagacccc tggaccacca gccccagcaa gagcacaaga ggaagagaga gaccctcact 1140
gctggggagt ccctgccaca ctcagtcccc caccacactg aatctcccct cctcacagtt 1200
gccatgtaga ccccttgaag aggggagggg cctagggagc cgcaccttgt catgtaccat 1260
caataaagta ccctgtgctc aaccagttaa aaaaaaaaaa aaaaaaaaa 1309
Claims (11)
- VISFATIN 유전자에 상보적인 프라이머(primer) 세트 또는 프로브를 포함하는, 급성창상 치료제 스크리닝용 조성물.
- 제1항에 있어서,
상기 프로브는 형광 표지 물질을 갖는 표지 프로브인 것을 특징으로 하는, 급성창상 치료제 스크리닝용 조성물.
- VISFATIN 유전자로부터 코딩되는 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 급성창상 치료제 스크리닝용 조성물.
- 제1항 또는 제3항의 조성물을 포함하는 급성창상 치료제 스크리닝용 키트.
- (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;
(b) 상기 섬유아세포에서 VISFATIN의 유전자 발현량을 측정하는 단계; 및
(c) 상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 급성창상 치료제로 선별하는 단계;
를 포함하는, 급성창상 치료제를 스크리닝하는 방법.
- VISFATIN 유전자로부터 코딩되는 단백질을 유효성분으로 포함하는, 급성창상 치료용 약학적 조성물.
- 제6항에 있어서,
상기 조성물은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1, FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3, IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH의 유전자로부터 코딩되는 단백질로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 더 포함하는 것을 특징으로 하는, 급성창상 치료용 약학적 조성물.
- 제6항에 있어서,
상기 급성창상 치료용 약학적 조성물은,
ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시키는 것을 특징으로 하는, 급성창상 치료용 약학적 조성물.
- 제1항에 있어서,
상기 조성물은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1, FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3, IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머 세트 또는 프로브 세트를 더 포함하는 것을 특징으로 하는, 급성창상 치료제 스크리닝용 조성물.
- 제3항에 있어서,
상기 조성물은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1, FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3, IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH의 유전자로부터 코딩되는 단백질로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 더 포함하는 것을 특징으로 하는, 급성창상 치료제 스크리닝용 조성물.
- 제5항에 있어서,
상기 (b)단계는 섬유아세포에서 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1, FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3, IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 더 측정하는 것을 특징으로 하는, 급성창상 치료제를 스크리닝하는 방법.
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