KR20100037637A - Ｅｇｆｒ 억제제 치료에 대한 예측 마커 - Google Patents

Ｅｇｆｒ 억제제 치료에 대한 예측 마커 Download PDF

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KR20100037637A
KR20100037637A KR1020107003315A KR20107003315A KR20100037637A KR 20100037637 A KR20100037637 A KR 20100037637A KR 1020107003315 A KR1020107003315 A KR 1020107003315A KR 20107003315 A KR20107003315 A KR 20107003315A KR 20100037637 A KR20100037637 A KR 20100037637A
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뽈 델마
바르바라 클루그함머
베레나 루츠
파트리샤 맥러플린
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에프. 호프만-라 로슈 아게
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Abstract

본 발명은 암 환자에서 EGFR 억제제 치료의 임상적 이득을 예측하는 바이오마커를 제공한다.

Description

ＥＧＦＲ 억제제 치료에 대한 예측 마커 {PREDICTIVE MARKERS FOR EGFR INHIBITOR TREATMENT}
본 발명은 암 환자에서의 EGFR 억제제 치료의 임상적 이득을 예측하는 바이오마커를 제공한다.
다수의 인간 악성종양은 상피 성장 인자 수용체 (EGFR)의 일탈 또는 과발현과 연관되어 있다. EGF, 형질전환 성장 인자 α (TGF-α) 및 다수의 기타 리간드는 EGFR에 결합하여, 수용체의 세포내 타이로신 키나아제 도메인의 자가인산화를 자극한다. 여러 가지 세포내 경로들이 후속하여 활성화되며, 이들 하류방향 사건들은 시험관내 종양 세포 증식을 초래한다. EGFR을 통한 종양 세포의 자극이 생체내 종양 성장 및 종양 생존의 두 가지 모두에 중요하다는 것은 기정사실이다.
EGFR 타이로신 키나아제의 억제제인 TarcevaTM (에를로티니브)를 이용한 초기의 임상 데이터는, 그 화합물이 안전하며, 표적으로 하는 유효 농도를 제공하는 투여량 (전임상 데이터로 결정됨)에서 일반적으로 널리 용인된다는 것을 나타낸다. 진행된 질환이 있던 환자에서의 임상 I상 및 II상 시험은, TarcevaTM가 일정 범위의 상피 종양에서 유망한 임상 활성을 갖는다는 것을 증명했다. 실제로, TarcevaTM가 두경부암이 있는 환자 및 NSCLC (비-소세포 폐암)이 있는 환자에서 기존 확립된 2차 항암치료의 화학요법과 비슷한 정도로 오래가는 부분적인 차도를 유도할 수 있고, 화학요법보다 더 나은 안전성 프로파일 및 개선된 편의성 (정맥내 [i.v.] 투여 대신 정제)의 이득을 추가하는 것으로 나타났다. 최근 완결된, 무작위적인 이중맹검 위약 통제 시험 (BR.21)은, 진행된 질환에 대한 표준 요법이 실패한 NSCLC 환자의 생존을 단일 약제 TarcevaTM가 현저하게 연장시키고 개선시킨다는 것을 나타내었다.
TarcevaTM (에를로티니브)는 소형 화학 분자이다; 이는 경구 활성인, EGFR 타이로신 키나아제 (EGFR-TKI)의 강력하고 선택적인 억제제이다.
폐암은 북미 및 유럽에서 암 관련한 사망의 주된 요인이다. 미국에서, 폐암에 부차적인 사망자 숫자는 암 관련 사망 원인을 주도하여, 두 번째 (대장암), 세 번째 (유방암) 및 네 번째 (전립선암)를 총합한 사망자 수를 능가한다. 전체 폐암의 약 75% 내지 80%가 NSCLC이며, 약 40%의 환자들은 국소적으로 진행되고/되거나 수술로 치유불가능한 질환을 나타내고 있다. 이러한 군에는 일반적으로 악성 흉수를 제외한, 종양의 부피가 큰 병기 (stage)인 IIIA기 및 IIIB기 질환을 갖는 이들이 포함된다.
유럽 연합에서, 매년 폐암의 대략적인 발생률은 100,000명당 52.5명이며, 사망률은 48.7명이다. 남성들 중에서는 상기 비율이 79.3 및 78.3이며, 여성들 중에서는 상기 비율이 각각 21.6 및 20.5이다. NSCLC는 폐암 전체의 80%를 차지한다. 남성 폐암 사망의 약 90% 및 여성 폐암 사망의 80%는 흡연이 원인이다.
US에서, 미국 암 학회에 따르면, 2004년 동안, 약 173,800건의 신규한 폐암 발병 (남성 93,100건 및 여성 80,700건)이 있었으며, 이는 모든 신규한 암 발병의 약 13%를 차지했다. 대부분의 환자들은 진단 후 2년 내에 그 질환의 결과로 사망한다. 다수의 NSCLC 환자에 있어서, 성공적인 치료는 찾기 힘든 것으로 남아있다. 한참 진행된 종양은 종종 수술로도 치료불가능하며, 용인가능한 투여량의 방사선요법 및 화학요법에도 내성이 생길 수 있다. 무작위적인 시험에서, 현재 가장 활발한 병용 화학요법은 약 30% 내지 40%의 종양 반응률을 달성하며, 1년간 생존율은 35% 내지 40%이다. 이는 단독적인 보존적 치료가 보여주는 10%의 1년 생존율을 훨씬 앞선다 (Shepherd 1999).
최근까지, 재발한 환자에 대한 치료 선택폭은 최선의 보존적 치료 또는 일시적 완화로 제한되어 있었다. 도세탁셀 (Taxotere
Figure pct00001
)과 최상의 보존적 치료를 비교한 최근의 시험은, NSCLC가 있는 환자가, 시스플라틴 기반의 1차 항암치료의 식이요법이 실패한 후, 2차 항암치료의 화학요법으로 이득을 볼 수 있다는 것을 보여주었다. 모든 연령대의, ECOG 성능 상태 (performance status)가 0, 1 또는 2인 환자에서, 먼저 했던 백금-기반의 치료로는 치료가 어려웠던 이들에서처럼, 도세탁셀의 이용으로 생존이 개선되었음이 증명되었다. 요법으로 이득을 못 본 환자들에는, 10%의 체중 손실이 있거나, 락테이트 디하이드로게나아제 수준이 높거나, 여러 장기에 연루되어 있거나 또는 간에 연루되어 있는 이들이 포함된다. 추가적으로, 도세탁셀 단독요법의 이득은 2차 항암치료 설정을 넘어서진 못했다. 3차 이상의 항암치료로서 도세탁셀을 받은 환자들은 생존의 연장을 보여주지 않았다. 단일 약제 도세탁셀은 NSCLC에 대한 표준 2차 항암치료 요법이 되었다. 최근, NSCLC의 2차 항암치료 요법에서 또 다른 무작위적인 III상 시험에서는 페메트렉세드 (Alimta
Figure pct00002
)와 도세탁셀을 비교하였다. 페메트렉세드를 이용한 치료는 임상적으로 동등한 효능을 도출했으나, 도세탁셀보다 훨씬 더 적은 부작용이 있었다.
맞춤화된 암 치료 방법 개발에 대한 필요가 있음은 오래 전부터 인정되어 왔다. 표적으로 삼은 암 치료법을 개발하면서, 종양 표적의 분자적 프로파일을 제공할 수 있는 방법론 (즉, 임상적인 이득에 대해 예측되는 것)이 특별한 관심대상이 되었다. 암에서의 유전자 발현 프로파일에 대한 법칙의 증거는, 현재의 형태학적 및 면역세포화학적 시험을 근거로 하기에는 명확하지 않은 종양 유형의 분자적 분류를 이용하여 이미 확립되어 있다. 두 개별적 질환 주체는, 유전자 발현 프로파일링을 사용하여 미만성 대세포 B-세포 림프종의 단일한 현 분류로부터 상이한 예측으로 분화되었다.
그러므로, 암 환자에서 EGFR 억제제 치료의 임상적 이득을 예측하는 발현 바이오마커를 제공하는 것이 본 발명의 목표이다.
본 발명의 첫 번째 목적에서는, EGFR 억제제를 사용한 치료에 대해 반응하는 환자의 임상적 이득을 예측하는 시험관내 방법이 제공된다. 상기 방법은 하기 단계를 포함한다: 환자의 종양 샘플에서의 표 3으로부터 선택된 하나 이상의 유전자의 발현 수준을 측정하고, 하나 이상의 유전자의 발현 수준을, 치료로부터 임상적 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값에 대해 비교하는 단계 (여기서 환자의 종양 샘플에서의 하나 이상의 유전자의 차등 발현 수준은 치료로부터 임상적 이득을 얻을 환자에 대한 표식임).
용어 "치료로부터 임상적 이득을 얻지 못하는 환자 집단의 종양에서의 하나 이상의 마커 유전자의 발현 수준의 대표값"은 치료로부터 임상적 이득을 얻지 못하는 환자 집단의 종양에서의 마커 유전자의 평균 발현 수준에 대한 계산치를 나타낸다. 임상적 이득은 12주 이상 동안 목적된 반응 또는 질환 안정화를 갖는 것으로서 정의된다.
추가적인 바람직한 구현예에서, 둘 이상의 유전자의 발현 수준이 측정된다.
또 다른 바람직한 구현예에서, 셋 이상의 유전자의 발현 수준이 측정된다.
추가적인 바람직한 구현예에서, 유전자는 ATP6V0E1, MAPRE1, PSMA5, ACSL3, RAP1A, SLC2A3, CHMP2B, RFK, CTGF, HSPA8, AKAP12, LOX, SLMO2, NOMO3, APOO로 이루어지는 군에서 선택되며, 상기 유전자는 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 낮은 발현 수준을 나타낸다.
추가적인 바람직한 구현예에서, 유전자는 SDC1, CEBPA, ST6GALNAC2, PLA2G6, PMS2L11, C19orf7, DDX17, SFPQ, PMS2L3, SLC35E2, PMSL2, URG4, PPP1R13B, NRCAM, FLJ10916, FLJ13197, GPR172B, ZNF506, ARHGAP8, CELSR1, LYK5로 이루어지는 군에서 선택되며, 상기 유전자는 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 높은 발현 수준을 나타낸다.
바람직한 구현예에서, 하나 이상의 유전자의 발현 수준은 마이크로어레이 (microarray) 기술로 측정된다. 유전자칩의 구축 및 사용은 당업계에 널리 공지되어 있다. U.S. 특허 제 5,202,231 호; 제 5,445,934 호; 제 5,525,464 호; 제 5,695,940 호; 제 5,744,305 호; 제 5,795,716 호 및 제 5,800,992 호를 참조한다. 또한, Johnston, M. Curr. Biol. 8:R171-174 (1998); Iyer VR 등, Science 283:83-87 (1999)을 참조한다. 물론, 유전자 발현 수준은 당업자에게 공지된 기타 방법, 예를 들어 노던 블롯, RT-PCR, 실시간 정량 PCR, 프라이머 신장, RNase 보호, RNA 발현 프로파일링으로 측정될 수 있다.
본 발명의 유전자는 바이오마커 집합으로 조합될 수 있다. 바이오마커 집합은, 암 환자에서의 EGFR 억제제 치료의 효과에 대한 예측을 위해 표 3에 열거된 바이오마커의 임의 조합으로부터 성립될 수 있다. 본원에서 기재된 다양한 바이오마커 및 바이오마커 집합이, 예를 들어, EGFR 억제제를 사용한 치료적 개입에 대해 암 환자가 어떻게 반응할 것인지를 예측하는데 사용될 수 있다.
본원에서 사용되는 바와 같은 "유전자"라는 용어는 유전자의 변이체를 포함한다. "변이체"라는 용어는 GenBank 접근 번호로 주어진 핵산 서열과 실질적으로 유사한 핵산 서열에 관한 것이다. "실질적으로 유사한"이라는 용어는 당업자에게는 잘 이해된다. 특히, 유전자 변이체는 인간 집단 내에서 가장 우세한 대립형질의 핵산 서열과 비교하여 뉴클레오티드 교환을 보이는 대립형질일 수 있다. 바람직하게는, 이러한 실질적으로 유사한 핵산 서열은 80% 이상, 바람직하게는 85% 이상, 보다 바람직하게는 90% 이상, 가장 바람직하게는 95% 이상의 가장 우세한 대립형질과의 서열 유사성을 갖는다. "변이체"라는 용어는 또한 스플라이스 (splice) 변이체에 관한 것을 의미한다.
EGFR 억제제는 게피티니브, 에를로티니브, PKI-166, EKB-569, GW2016, CI-1033 및 항-erbB 항체, 예컨대 트라스투주마브 및 세툭시마브로 이루어진 군으로부터 선택될 수 있다.
또 다른 구현예에서, EGFR 억제제는 에를로티니브이다.
또 다른 구현예에서, 암은 NSCLC이다.
본 발명에 의해 기재되는 유전자의 유전자 발현의 검출 기술에는 노던 블롯, RT-PCR, 실시간 정량 PCR, 프라이머 확장, RNase 보호, RNA 발현 프로파일링 및 관련 기술이 포함되나 이에 제한되는 것은 아니다. 이러한 기술은 당업자에게 잘 알려져 있으며, 예를 들어 [Sambrook J 등, Molecular Cloning: A Laboratory Manual, Third Edition (Cold Spring Harbor Press, Cold Spring Harbor, 2000)]를 참조한다.
본 발명에 의해 기재되는 각 유전자의 단백질 발현 검출 기술에는 면역조직화학 (IHC; Immunohistochemistry)이 포함되나 이에 제한되는 것은 아니다.
본 발명에 따르면, 종양 또는 암 생검과 같은 환자 조직 샘플로부터의 세포를 검정하여, 하나 이상의 바이오마커의 발현 패턴을 측정할 수 있다. 암 치료의 성공 또는 실패는, 종양 또는 암 생검과 같은 시험 조직으로부터의 세포 (시험 세포)의 바이오마커 발현 패턴이, 하나 이상의 바이오마커의 대조군 집합의 발현 패턴과 비교적 유사 또는 상이한가에 근거해 결정될 수 있다. 본 발명의 문맥에서, EGFR 억제제 치료로부터 임상적 이득을 얻지 못한 환자의 종양과 비교하여 EGFR 억제제 치료로부터 임상적 이득을 얻은 환자의 종양에서, 표 3에 열거한 유전자가 차등적으로 발현된다는, 즉 보다 높은 또는 낮은 발현 수준을 보인다는 것을 발견하였다. 따라서, 시험 세포가 암 치료에 반응하였던 환자의 바이오마커 발현 프로파일에 상응하는 바이오마커 발현 프로파일을 보이는 경우, 개체의 암 또는 종양이 EGFR 억제제를 사용한 치료에 바람직하게 반응할 것 같거나 그러할 것으로 예상된다. 반대로, 시험 세포가 암 치료에 반응하지 않았던 환자의 바이오마커 발현 패턴에 상응하는 바이오마커 발현 패턴을 보이는 경우, 개체의 암 또는 종양이 EGFR 억제제를 사용한 치료에 바람직하게 반응하지 않을 것 같거나 그러할 것으로 예상된다.
본 발명의 바이오마커, 즉 표 3에 열거된 유전자는 암 환자, 특히 불응성 NSCLC 환자에 대한 맞춤 요법 (individualized therapy)을 향한 첫 번째 단계이다. 상기 맞춤 요법은 진료 의사가 암 치료요법, 특히 NSCLC에 대한 기존의 약물들 중 가장 적절한 제제를 선별할 수 있게 할 것이다. 각각의 미래의 환자에 대한 맞춤 요법의 이득은 하기와 같다: 반응률 / 이득을 얻는 환자의 수가 증가하고 비효과적인 치료로 인한 유해한 부작용의 위험성이 감소할 것이다.
본 발명의 추가 목적에서는 본 발명의 시험관내 방법에 의해 확인된 암 환자를 치료하는 치료 방법을 제공한다. 상기 치료 방법은 표 3에 열거된 유전자 중 하나 이상의 예측 발현 패턴에 근거해 치료하기로 선택된 환자에게 EGFR 억제제를 투여하는 것을 포함한다. 바람직한 EGFR 억제제는 에를로티니브이고, 치료하고자 하는 바람직한 암은 NSCLC이다.
도 1은 연구 설계를 보여준다;
도 2는 샘플 처리에 대한 도식을 보여준다;
실험적 부분
연구에 대한 근거 및 연구 설계
최근 NSCLC 환자의 하위집합의 종양 조직 내의 EGFR 유전자에서의 돌연변이 및, 에를로티니브 및 게피티니브에 대한 감수성을 가진 이러한 돌연변이의 연관성이 기재되어 있다 (Pao W, 등. 2004; Lynch 등. 2004; Paez 등. 2004). 2가지 연구를 조합한 경우 환자에서, 돌연변이된 EGFR은 게피티니브에 반응을 보였던 환자 14명 중 13명에서 관찰되었고, 반응을 보이지 않았던 11명의 게피티니브-처리된 환자에서는 관찰되지 않았다. 이들 돌연변이의 보고된 유병률은 미선별된 NSCLC 환자 중 8% (25명 중 2명)에 달했다. 이들 돌연변이는 선암 (21%), 여성으로부터의 종양 (20%), 및 일본인 환자로부터의 종양 (26%)에서 보다 자주 발견되었다. 이들 돌연변이는 EGFR의 시험관내 활성 증가 및 게피티니브에 대한 감수성 증가를 야기하였다. 돌연변이와 장기적으로 안정된 질환 또는 생존 기간과의 관계는 유망하게 평가되지는 않았다.
BR.21 연구로부터의 예비 분석에 근거하여, 심지어 목적하는 반응을 보이는 환자를 분석에서 제외시킨 경우에도 유의한 생존 이득이 유지되기 때문에 (자료에 근거함), 관찰되는 생존 이득은 EGFR 돌연변이로 인한 것만은 아닌 것으로 보인다. 기타 분자 메커니즘도 또한 효과에 기여하는 것이 분명하다.
TarcevaTM 치료에 대한 반응/이득을 예측하는 유전자 발현 수준의 변화가 있다는 가정에 근거하여, 마이크로어레이 분석을 사용하여 이들 변화를 측정하였다.
이를 위해서는 1차 요법의 실패 후 TarcevaTM 단일요법으로 치료된 명확하게 정의된 연구 집단이 필요하였다. BR.21 연구로부터의 경험에 근거하여, 이득을 얻은 집단을 목적하는 반응, 또는 12주 동안의 질환 안정화를 가진 것으로서 정의하였다. 임상 및 마이크로어레이 데이터 집합을 사전 정의된 통계 계획에 따라 분석하였다.
이 기술을 적용하기 위해서는 신선한 동결 조직 (FFT; fresh frozen tissue)이 필요하다. 그러므로, 처리 시작 전에 의무적인 생검을 수행해야만 한다. 수집된 물질을 액체 질소 (N2)에서 동결시켰다.
동시에 두 번째 종양 샘플을 수집하고, 파라핀에 저장하였다 (포르말린 고정 파라핀 포매: FFPE; formalin fixed paraffin embedded). 상기 샘플을 EGFR 신호 경로에서의 변경에 대해 분석하였다.
기관지경술을 통한 종양 생검을 실시하는 역량이 본 연구를 위한 전제 조건이었다. 기관지경술은 폐암 진단을 확인하기 위한 표준 절차이다. 일반적으로 안전하지만, 출혈과 같은 합병증의 위험이 남아있다.
본 연구는 난치성 NSCLC를 갖는 환자들에 대한 맞춤 요법을 향한 첫 단계였다. 상기 맞춤 요법은 진료 의사가 상기 징후에 대해 기존의 약물들 중 가장 적절한 제제를 선별할 수 있게 할 것이다.
일단 맞춤 요법이 가능해지면, 미래의 각 환자에 대한 이득은 현재의 연구에서 환자들이 감수해야 하는 위험을 능가할 것이다:
반응률 / 이득을 얻는 환자의 수가 증가할 것이고,
비효과적인 치료로 인한 유해한 부작용의 위험성이 감소할 것이다.
투여량 선택에 대한 근거
TarcevaTM를 질환 진행, 용인불가한 독성 또는 사망시까지 150 mg의 투여량으로 1일 1회 경구 투여하였다. 상기 투여량에 대한 선택은 약동학적 변수 뿐 아니라 사전-치료를 과도히 받은 진행된 암 환자들에서 제 I, II 및 III상 시험에서 관찰된 상기 투여량의 안전성 및 내약성 프로파일을 근거로 하였다. 150　mg/일 투여량을 받은 암 환자들의 혈장에서 나타난 약물 수준은 임상적 효능을 목적으로 하는 500　ng/ml의 평균 혈장 농도보다 높은 수준으로 일정했다. BR.21은, 상기 투여량으로 생존 이득을 보여주었다.
상기 연구의 목적
이의 일차적 목적은 TarcevaTM 치료의 임상적 이득 (CR, PR 또는 SD ≥ 12주)을 예측하는 차등 발현 유전자들을 확인하는 것이었다. TarcevaTM 치료에 대한 "반응" (CR, PR)을 예측하는 차등 발현 유전자들의 확인은 중요한 추가적인 목적이었다.
부차적인 목적은, 치료를 통한 이득에 관해서, EGFR 신호전달 경로에서의 변경을 평가하는 것이었다.
연구 설계
연구 설계 및 투여 방법에 대한 개관
이는 공개 (open-label) 예측 마커 확인 제 II상 연구였다. 본 연구는 약 12개국의 대략 26개 지역에서 수행되었다. 1가지 이상의 사전 화학요법이 실패한 진행성 NSCLC를 가진 264명의 환자가 12개월의 기간에 걸쳐 등록하였다. 지속적으로 경구 TarcevaTM가 150　mg/일의 투여량으로 투여되었다. 약물 요법에 대한 내약성에 근거하여 투여량 감소가 허용되었다. 질환 조절 및 독성을 평가하기 위해 임상 및 실험 매개변수들을 검토 평가하였다. 치료는 질환 진행, 허용불가능한 독성 또는 사망시까지 계속되었다. 당해 연구 설계를 도 1에 나타내었다.
분자적 분석을 위해 종양 조직 및 혈액 샘플을 수득하여, TarcevaTM의 효과를 평가하고 치료를 통해 이득을 얻는 환자들의 하위군을 확인하였다.
예측 마커 평가
종양 생검은 치료 시작 전 2주 내에 취하였다. 하기 2가지의 상이한 샘플을 채취하였다:
첫 번째 샘플은 항상 액체 N2 중에 즉시 동결시켰다.
두 번째 샘플은 포르말린 중에 고정시킨 후 파라핀 중에 포매시켰다.
즉시 동결 조직은 본 연구에서 가장 높은 우선순위를 가졌다.
도 2는 샘플 처리에 대한 도식을 나타낸다.
마이크로어레이 분석
종양 RNA 및 종양 주변 조직으로부터의 RNA를 추출하기 위한 종양 세포의 레이저 포획 미세절제 (laser capture microdissection; LCM)에 상기 즉시 동결 샘플을 사용하였다. 상기 RNA를 Affymetrix 마이크로어레이 칩 (HG-U133A) 상에서 분석하여 상기 환자들의 종양 유전자 발현 프로파일을 확립하였다. Affymetrix 칩에 대한 품질 관리를 사용하여 통계학적 비교를 위한 적절한 품질의 샘플을 선택하였다.
포르말린 고정된 파라핀 포매 조직에 대한 단일 바이오마커 분석
상기 두 번째 종양 생검인 FFPE 샘플을 사용하여, DNA 돌연변이, IHC 및 ISH 분석을 하기 기재한 바와 같이 수행하였다. 초기 진단시 수집된 조직에 대해서도 유사한 분석을 수행하였다.
EGFR 및 EGFR 신호전달 경로에 관여하는 기타 분자를 인코딩하는 유전자의 DNA 돌연변이 상태를 DNA 서열분석으로써 분석하였다. EGFR 및 관련 유전자들의 유전자 증폭은 FISH로 연구되었다.
단백질 발현 분석에는 EGFR 및 EGFR 신호전달 경로 내에서의 기타 단백질의 면역조직화학 [IHC] 분석이 포함되었다.
반응 평가
RECIST (Uni-dimensional Tumour Measurement) 기준을 사용하여 반응을 평가하였다. 상기 기준은 하기 링크에서 찾아볼 수 있다: http://www.eortc.be/recist/
다음을 주의해야 한다: CR 또는 PR의 상태로 규정하기 위해서는, 상기 치료 기간 중의 임의의 시점과는 적어도 4주 떨어진 시점에서의 반복 평가에 의해 종양 측정치의 변화가 확인되어야 한다.
SD의 경우, 후속적인 측정치가 연구 시작 후 최소 6주의 간격으로 적어도 1회 SD 기준을 충족해야 한다.
SD 유지의 경우, 후속적인 측정치가 연구 시작 후 12주 이상의 지속 시간에 걸쳐 적어도 1회 SD 기준을 충족해야 한다.
생존 평가
환자가 진료소로 방문하거나 또는 전화에 의해 3개월마다 정기적인 상태 체크를 수행하였다. 모든 사망을 기록하였다. 연구의 말미에는 각 환자에 대해 최종적 생존 확인이 필요하였다.
방법
RNA 샘플 제조 및 RNA 샘플에 대한 품질 관리
모든 생검 샘플 처리는 병리학 표준 실험실에서 다루어졌고; 새로 동결된 조직 샘플은 조사기관 지역에서 Roche Basel의 임상 샘플 작업 (Clinical Sample Operations) 시설로 수송되었고, 추가적인 처리를 위해 거기에서 병리학 실험실로 수송되었다. 레이저 포획 미세절제를 사용하여 주변 조직으로부터 종양 세포를 선별하였다.
LCM 후, 상기 종양 풍부 물질로부터 RNA를 정제하였다. 상기 병리학 실험실은 그 후 상기 RNA의 농도 및 품질에 대한 추정을 위한 일련의 단계를 실행하였다.
RNase는 RNA 분해 효소이며 도처에서 발견되고, 따라서 RNA가 사용될 모든 절차는 RNA 분해를 최소화하도록 엄격히 조절되어야만 한다. 대부분의 mRNA 종은 자체적으로 다소 짧은 반감기를 가지며, 따라서 상당히 불안정한 것으로 간주된다. 그러므로, 임의 검정 전에 RNA 보전성 체크 및 정량화를 수행하는 것이 중요하다.
RNA 농도 및 품질 프로파일은 2100 Bioanalyzer
Figure pct00003
로 불리는 Agilent 기기 (Agilent Technologies, Inc., Palo Alto, CA)를 사용하여 평가될 수 있다. 기기 소프트웨어는 RNA 보전성 번호 (RIN), 정량화 추정 (Schroeder, A., 등, The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol, 2006. 7: p.3)을 생성하고, 총 RNA 샘플의 리보솜 비율을 계산한다. RIN은 RNA 샘플의 전체 전기영동적 추적으로부터 측정되며, 이에는 분해 생성물의 존재 또는 부재가 포함된다.
RNA 품질을 2100 Bioanalyzer
Figure pct00004
로 분석하였다. Affymetrix 플랫폼 상에서의 추가적 분석을 위해, 충분한 RNA 및 첨가된 폴리-I 노이즈 초과의 하나 이상의 rRNA 피크를 갖는 샘플만을 선택하였다. 마이크로어레이에 의한 분석을 위해, 정제된 RNA를 로셰 의학 게놈학 센터 {Roche Centre for Medical Genomics (RCMG; Basel, Switzerland)}로 보냈다. 추가적인 처리를 위해 병리학 실험실로부터 122개 RNA 샘플을 받았다.
조직 RNA 샘플의 표적 표지
제조사의 지시사항에 따른 것으로서, Affymetrix로부터의 2-사이클 표적 표지 증폭 프로토콜 (Affymetrix, Santa Clara, California)에 따라 표적 표지를 실행하였다.
상기 방법은 표준 에버와인 선형 증폭 방법을 기준으로 하지만, 마이크로어레이에 대한 하이브리드화를 위해 충분히 표지된 cRNA가 생성되도록 상기 방법의 두 사이클을 사용한다.
표지 반응에서 사용된 총 RNA 투입량은, 10 ng 초과의 RNA가 활용가능한 경우 이들 샘플에 대해 10 ng 이었고; 상기 양 미만이 활용가능하거나 또는 활용가능한 양 데이터가 없는 경우 (매우 낮은 RNA 농도로 인해), 총 샘플의 절반을 반응에 사용하였다. 표지 반응으로부터의 수율은 20 ~ 180 μg cRNA이었다. 15 μg cRNA가 모든 샘플에 대해 사용된 하이브리드화의 수준에서 표준화 단계를 도입하였다.
인간 참조 RNA (Stratagene, Carlsbad, CA, USA)를, 샘플 각각의 뱃치 (batch)로의 작업량 내에서 대조군 샘플로서 사용하였다. 10 ng의 상기 RNA를 시험 샘플과 함께 투입으로서 사용하여, 표지 및 하이브리드화 시약이 예측한 바와 같이 작용하는지 확인하였다.
마이크로어레이 하이브리드화
Affymetrix HG-U133A 마이크로어레이는 약 14,500개의 잘 분석된 유전자를 나타내는 약 18,400개의 전사체 및 변이체를 표적하는 22,000개 초과의 프로브 집합을 포함한다.
Affymetrix 지시사항 (Affymetrix Inc., Expression Analysis Technical Manual, 2004)에 따라 모든 샘플에 대한 하이브리드화를 실행하였다. 간략하게는, 각각의 샘플에 대해, 15 μg의 바이오틴-표지된 cRNA를 2가 양이온의 존재 하 및 가열 하에 절편화하고, Affymetrix HG-U133A 전체 게놈 올리고뉴클레오티드 어레이에서 하룻밤 동안 하이브리드화하였다. 다음날 어레이를 제조사의 지시사항에 따라 스트렙타비딘-피코에리트린 (Molecular Probes; Eugene, OR)으로 염색하였다. 이후 GeneChip Scanner 3000 (Affymetrix)을 사용하여 어레이를 스캐닝하고, GeneChip Operating Software (GCOS) 버전 1.4 (Affymetrix)로 신호 세기를 자동으로 계산하였다.
통계적 분석
AffymetrixTM 데이터의 분석은 5개 주요 단계로 구성되었다.
단계 1은 품질 관리였다. 목표는 하위-표준 품질 프로파일을 갖는 어레이 데이터를 확인하고 분석에서 제외시키는 것이었다.
단계 2는 예비-처리 및 표준화였다. 목표는 칩 간 비교되어야 할 표준화 및 스케일화된 "분석 데이터 집합"을 생성하는 것이었다. 이는 배경 노이즈 추정 및 감산, 프로브 요약 및 스케일링을 포함하였다.
단계 3은 탐색 및 설명이었다. 목표는 가변성의 공급원 및 잠재적 경향을 확인하는 것이었다. 이는 다변 및 단변 설명적 분석 기술을 적용하여 유력한 공변 (covariate)을 확인하는 것으로 이루어졌다.
단계 4는 모델링 및 시험이었다. 목표는 "임상적 이득" 및 "임상적 무이득" 환자 사이의 평균 발현 수준에서의 차이의 통계적 평가를 기준으로 후보 마커의 목록을 확인하는 것이었다. 이는 각각의 프로브-집합에 대해 적당한 통계적 모델을 맞추고 통계적 유의성의 측정을 추론하는 것으로 이루어졌다.
단계 5는 견고성 (robustness) 분석이었다. 목표는 예비-처리 방법 및 통계적 가정에 많이 의존하지 않는 후보 마커의 적격 목록을 생성하는 것이었다. 이는 상이한 방법론적 접근으로 분석을 반복하고, 후보 목록을 교차시키는 것으로 이루어졌다. R 소프트웨어 패키지를 사용하여 모든 분석을 수행하였다.
단계 1: 품질 관리
데이터 품질의 평가는 여러 매개변수의 체크를 기준으로 하였다. 이들에는 표준 Affymetrix GeneChipTM 품질 매개변수, 특히 스케일링 인자, 현존 호출 % (Percentage of Present Call) 및 평균 배경이 포함된다. 이러한 단계에는 또한 국지적 하이브리드화 문제점을 검출하기 위한 가상 칩 영상의 시각적 검사, 중간 거동으로부터의 임의 비정상적 이탈을 검출하기 위한, 가상 중간 칩에 대한 각각의 칩의 비교가 포함된다. 칩 간 상관관계 분석을 또한 수행하여 특이점 (outlier) 샘플을 검출하였다. 또한, Agilent BioanalyzerTM 2100으로 RNA 샘플을 분석하여 수득한 RNA 품질의 부수적 측정을 고려하였다.
이들 매개변수를 기준으로, 20개 어레이로부터의 데이터를 분석에서 제외시켰다. 따라서 102명 환자를 나타내는 총 102개 어레이로부터의 데이터를 분석에 포함시켰다. 이들 102개 샘플 집합의 임상적 설명을 하기 표 1에 나타내었다.
분석에 포함된 환자의 임상적 특징 설명
변수 값 n = 102
n (%)
최상의 반응 N/A 16 (15.7%)
PD 49 (48.0%)
SD 31 (30.4%)
PR 6 (5.9%)
임상적 이득 없음 81 (79.4%)
있음 21 (20.6%)
성별 여성 25 (24.5%)
남성 77 (74.5%)
인종 백인 65 (63.7%)
동양인 37 (36.3%)
조직학 선암 35 (34.3%)
편평 53 (52.0%)
기타 14 (13.7%)
흡연 경험 없음 20 (19.6%)
있음 82 (80.4%)
단계 2: 데이터 예비-처리 및 표준화
rma 알고리즘 (Irizarry, R.A., 등, Summaries of Affymetrix GeneChip probe level data. Nucl. Acids Res., 2003. 31(4): p. e15)을 예비-처리 및 표준화에 사용하였다. mas5 알고리즘 (AFFYMETRIX, GeneChip
Figure pct00005
Expression: Data Analysis Fundamentals. 2004, AFFYMETRIX)을, 개별적 프로브-집합에 대한 검출 호출을 만드는데 사용하였다. 모든 샘플에서의 "부재" 또는 "최저한 (marginal)"이라 칭하는 프로브-집합을 추가적 분석에서 제거하고; 5930개 프로브-집합을 상기 기준을 근거로 분석에서 제거하였다. 그러므로 분석 데이터 집합은 102명 환자에서 측정된 16353개 (22283개 중) 프로브-집합을 갖는 매트릭스로 이루어졌다.
단계 3: 데이터 설명 및 탐색
설명적 탐색 분석 (Descriptive exploratory analysis)을 수행하여 가변성의 주요 공급원 및 잠재적 경향을 확인하였다. 유전자 발현 프로파일에 대해 잠재적 영향을 갖는 공변 집합을 스크리닝하였다. 이는 기술적 및 임상적 변수를 모두 포함하였다. 기술적 공변에는 하기가 포함된다: RNA 처리 일자 (이후 뱃치로서 지칭됨), RIN (Schroeder, A., 등, The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol, 2006. 7: p. 3) (RNA 품질/보전성의 측정으로서), 조작자 및 샘플 채취 센터. 임상적 공변에는 하기가 포함된다: 조직학 유형, 흡연 상태, 종양 등급, 성능 점수 (Oken, M.M., 등, Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol, 1982. 5(6): p. 649-55), 인구 통계학적 데이터, 반응자 상태 및 임상적 이득 상태.
분석 도구에는 단변 ANOVA 및 주요 성분 분석이 포함된다. 각각의 공변에 대해, 단변 ANOVA를 각각의 프로브-집합에 대해 독립적으로 적용하였다.
뱃치 변수의 유의한 효과가 확인되었다. 실제로, 뱃치 변수는 샘플 처리 일자와 Affymetrix 칩 롯트 (lot)의 일자 사이의 차이를 포착하였다. 뱃치 변수가 관심 변수와 거의 독립적인 것을 체크한 후, [Johnson, W.E., C. Li, 및 A. Rabinovic, Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostat, 2007. 8(1): p. 118-127]에 기재된 방법을 사용하여 뱃치 영향을 정정하였다.
뱃치 영향 정정 후 표준화된 데이터 집합은 후속 분석에서 분석 데이터 집합으로서 역할하였다.
조직학 및 RIN은 설명적 분석에 의해 강조된 두 추가적인 중요한 변수였다.
단계 4: 데이터 모델링 및 시험
선형 모델을 각각의 프로브-집합에 대해 독립적으로 맞추었다. 모델에 포함되는 변수를 표 2에 나타내었다. 최우 추정법 기술 (maximum likelihood technique)로 모델 매개변수를 추정하였다. "임상적 이득" 변수 (X1)에 상응하는 매개변수를 사용하여 임상적 이득을 갖는 환자군과 임상적 이득이 없는 환자군 사이의 발현 수준 차이를 평가하였다.
선형 모델에 포함된 변수의 설명
변수 유형 값
유전자 발현 의존적 (Yip) 환자 p에서의 프로브-집합 i의 log2 세기
절편 전체 평균 (μ)
임상적 이득 관심 예측자 (X1) 있음/없음
조직학 조정 공변 (X2) 선암/편평/기타
인종 조정 공변 (X3) 동양인/백인
성별 조정 공변 (X4) 여성/남성
RIN 조정 공변 (X5) [2,...,7.9]
흡연자 조정 공변 (X6) 현재/과거/무경험
병기 조정 공변 (X7) 비절제.III/IV
각각의 프로브-집합 i에 대해, 통계적 시험의 목표는, 표 2에 열거한 기타 조정 공변을 고려하여, 임상적 이득을 갖는 환자 및 임상적 이득을 갖지 못한 환자에서의 평균 발현 수준이 동등하다는 가설을 거부하는 것이었다. 공식적으로, 동등성의 무효적 가설을 두 측면의 대안에 대해 시험하였다. 상응하는 p-값을 표 3에 나타내었다.
두 가지 이유에 의해 선형 모델의 선택이 유발되었다. 첫째로, 선형 모델은 다목적적이며, 잘 분석되고 견고성 접근적이어서, 관심 변수의 영향을 추정하는 경우 혼동 변수가 조정되도록 한다. 둘째로, 샘플 크기 102가 주어지고, 데이터 집합의 표준화 및 스케일링, 정상 분포 가정이 합리적이고 정당하였다.
각각의 프로브-집합에 대해, 잔류 모델을 기준으로 플리그너-킬린 (Fligner-Killeen) 시험을 사용하여 변동의 동질성 가정을 추정하였다. 분석은 하기 3개 단계로 이루어졌다:
1. 잔류 변수의 동질성에 대해 각각의 분류별 변수를 시험하는 단계,
2. 최소 p-값을 갖는 변수 V에 주의하는 단계, 및
3. 최소 p-값이 0.001 미만인 경우, 상이한 수준의 변수 V가 상이한 변동을 갖도록 모델을 다시 맞추는 단계.
단계 5: 견고성
견고성 분석의 목표는 예비-처리 단계 또는 통계적 분석의 기초가 되는 가정의 결과로서 분석 결과가 인위적일 수 있는 위험성을 감소시키는 것이었다. 하기의 세 가지 측면이 고려되었다: a) 품질 관리 단계에서의 몇몇 여분의 칩의 포함 또는 제외; b) 예비-처리 및 표준화 알고리즘; c) 통계적 가정 및 시험 접근.
상이한 분석 설정을 갖는 유의함으로서 일관적으로 표명된 유전자의 하위집합으로서 후보 마커의 목록을 정의하였다. 상이한, 적용된 분석 옵션은 하기와 같다:
a) 보다 엄격한 품질 관리 기준을 근거로 8개 칩의 추가적인 하위집합을 확인하였다. 이들 8개 칩을 제외시킴으로써 "감소된 데이터 집합"을 정의하였다.
b) 예비-처리 및 표준화용 rma에 대한 대안물로서 MAS5를 확인하였다. MAS5는 배경 추정, 프로브 요약 및 표준화에 대해 상이한 방법을 사용한다.
c) 하기 2가지의 추가적인 통계학적 시험을 사용하였다. 이들 두 추가적인 시험은 기초가 되는 통계적 가정의 상이한 집합에 의지한다.
a. 임상적 이득ㆍ임상적 무이득 사이의 차이에 대한 윌콕슨 (wilcoxon) 시험 및
b. 응답 변수로서 임상적 이득을 취하고 공변으로서 유전자 발현을 취하는 로지스틱 회귀 (logistic regression) 모델을 시험하는 우도비 시험 (LRT; likelihood ratio test). 각각의 프로브-집합에 있어서, LRT는 1 자유도의 카이-제곱을 따랐다.
요약하면, 2가지 집합의 샘플 ("풀 (full)" 데이터-집합 및 "감소된 (reduced)" 데이터-집합), 및 2가지의 예비-처리된 알고리즘 (mas5 및 rma)이 고려되었다; 이는 4가지의 상이한 분석 데이터 집합을 산출하였다. 상기 4가지의 데이터 집합 각각에, 3가지의 상이한 통계학적 시험을 적용하였다. 그러므로, 각 프로브-집합에 대해, 3가지 p-값을 계산하였다. 각각의 분석 데이터 집합에서, 복합 기준을 적용하여, 차등적으로 조절되는 유전자 목록을 확인하였다. 상기 기준을 다음과 같이 정의하였다: 최대 p-값은 0.05 미만이고, p-값의 기하 평균은 0.01 미만이다.
마커 유전자를 확인하기 위해 기준 2를 사용하는 견고성 분석으로 36개 상이한 유전자에 상응하는 36개 프로브-집합의 목록이 야기되었다. 이들 마커를 표 3에 열거하였다.
표 3: 복합 기준 적용 후 견고성 분석에 근거한 임상적 이득에 대한 유전자 마커.
제 1열은 프로브-집합의 Affymetrix 확인자이다. 제 2열은 상응하는 유전자 서열의 GenBank 접근 번호이다. 제 3열은 상응하는 공식적인 유전자 명칭이다. 제 4열은 선형 모델로 추정된 바와 같은 임상적 이득ㆍ임상적 무이득 환자 사이의 발현 수준에 있어서의 상응하는 조정 평균 배수 변화이다. 제 5열은 선형 모델로부터 유도된 바와 같은 임상적 이득ㆍ임상적 무이득 환자 사이의 발현 수준에 있어서의 차이 시험에 대한 p-값이다.
Figure pct00006
Figure pct00007
토의
조직 샘플을 고밀도 올리고뉴클레오티드 마이크로어레이 기술을 사용하여 분석하고, 그 데이터에 통계학적 모델링을 적용함으로써, 본 발명자들은 발현 수준을 통해, 에를로티니브를 사용한 치료로부터 임상적 이득을 얻는 환자를 예측할 수 있는 유전자를 확인할 수 있었다.
복합 기준 (상기 정의한)을 적용하였고, 35개의 공지된 유전자를 나타내는 36개 프로브 집합의 목록 (표 3 참조)이 야기되었다. 이들 유전자의 기능은 복합적이며 항상 잘 분석되거나 완전히 이해되지는 않는다.
Ingenuity 소프트웨어 (Ingenuity
Figure pct00008
Systems, www.ingenuity.com)를 사용하여 표 3에서의 유전자의 기능적 주석을 분석하였다. 상기 소프트웨어는 과학 문헌을 근거로 동의되고 규칙적으로 업데이트된 유전자 주석의 독점적 지식 기초에 대한 인터페이스를 제공한다.
상기 포괄적인 (global) 분석은, 표 3이 상이한 종양 카테고리, 특히 EGFR 억제제 에를로티니브에 대한 반응에 관해, 이를 구별하는데 유용한 유전자를 포함한다는 것을 보여준다.
표 4: 본 발명의 마커 유전자 목록
제 1열은 인간 유전자 서열의 GenBank 접근 번호이고; 제 2열은 상응하는 공식적인 유전자 명칭이며 제 3열은 본 출원에서 사용된 바와 같은 인간 뉴클레오티드 서열의 서열 확인 번호 (Sequence Identification number)이다. 유전자의 여러 변이체가 GenBank에 등록되어 있기 때문에, 특정 유전자에 대해서 표 4에는 하나 이상의 서열 확인 번호가 포함된다.
Figure pct00009
Figure pct00010
Figure pct00011
<110> F. Hoffmann-La Roche AG <120> Predictive markers for EGFR inhibitor treatment <130> 24404WO <150> EP07114292.1 <151> 2007-08-14 <160> 54 <170> PatentIn version 3.4 <210> 1 <211> 894 <212> DNA <213> Homo sapiens <400> 1 aggcggggct tgcacacgct ggtcacgcgg tcagctattg acacttcctg gtgggatccg 60 agtgaggcga cggggtaggg gttggcgctc aggcggcgac catggcgtat cacggcctca 120 ctgtgcctct cattgtgatg agcgtgttct ggggcttcgt cggcttcttg gtgccttggt 180 tcatccctaa gggtcctaac cggggagtta tcattaccat gttggtgacc tgttcagttt 240 gctgctatct cttttggctg attgcaattc tggcccaact caaccctctc tttggaccgc 300 aattgaaaaa tgaaaccatc tggtatctga agtatcattg gccttgagga agaagacatg 360 ctctacagtg ctcagtcttt gaggtcacga gaagagaatg ccttctagat gcaaaatcac 420 ctccaaacca gaccactttt cttgacttgc ctgttttggc cattagctgc cttaaacgtt 480 aacagcacat ttgaatgcct tattctacaa tgcagcgtgt tttcctttgc cttttttgca 540 ctttggtgaa ttacgtgcct ccataacctg aactgtgccg actccacaaa acgattatgt 600 actcttctga gatagaagat gctgttcttc tgagagatac gttactctct ccttggaatc 660 tgtggatttg aagatggctc ctgccttctc acgtgggaat cagtgaagtg tttagaaact 720 gctgcaagac aaacaagact ccagtggggt ggtcagtagg agagcacgtt cagagggaag 780 agccatctca acagaatcgc accaaactat actttcagga tgaatttctt ctttctgcca 840 tcttttggaa taaatatttt cctcctttct atggaaatct ggaaaaaaaa aaaa 894 <210> 2 <211> 2540 <212> DNA <213> Homo sapiens <400> 2 acgagacgaa gacggaaccg gagccggttg cgggcagtgg acgcggttct gccgagagcc 60 gaagatggca gtgaacgtat actcaacgtc agtgaccagt gataacctaa gtcgacatga 120 catgctggcc tggatcaatg agtctctgca gttgaatctg acaaagatcg aacagttgtg 180 ctcaggggct gcgtattgtc agtttatgga catgctgttc cctggctcca ttgccttgaa 240 gaaagtgaaa ttccaagcta agctagaaca cgagtacatc cagaacttca aaatactaca 300 agcaggtttt aagagaatgg gtgttgacaa aataattcct gtggacaaat tagtaaaagg 360 aaagtttcag gacaattttg aattcgttca gtggttcaag aagtttttcg atgcaaacta 420 tgatggaaaa gactatgacc ctgtggctgc cagacaaggt caagaaactg cagtggctcc 480 ttcccttgtt gctccagctc tgaataaacc gaagaaacct ctcacttcta gcagtgcagc 540 tccccagagg cccatctcaa cacagagaac cgctgcggct cctaaggctg gccctggtgt 600 ggtgcgaaag aaccctggtg tgggcaacgg agacgacgag gcagctgagt tgatgcagca 660 ggtcaacgta ttgaaactta ctgttgaaga cttggagaaa gagagggatt tctacttcgg 720 aaagctacgg aacattgaat tgatttgcca ggagaacgag ggggaaaacg accctgtatt 780 gcagaggatt gtagacattc tgtatgccac agatgaaggc tttgtgatac ctgatgaagg 840 gggcccacag gaggagcaag aagagtatta acagcctgga ccagcagagc aacatcggaa 900 ttcttcactc caaatcatgt gcttaactgt aaaatactcc cttttgttat ccttagagga 960 ctcactggtt tcttttcata agcaaaaagt acctcttctt aaagtgcact ttgcagacgt 1020 ttcactcctt ttccaataag tttgagttag gagcttttac cttgtagcag agcagtatta 1080 acatctagtt ggttcacctg gaaaacagag aggctgaccg tggggctcac catgcggatg 1140 cgggtcacac tgaatgctgg agagatgtat gtaatatgct gaggtggcga cctcagtgga 1200 gaaatgtaaa gactgaattg aattttaagc taatgtgaaa tcagagaatg ttgtaataag 1260 taaatgcctt aagagtattt aaaatatgct tccacatttc aaaatataaa atgtaacatg 1320 acaagagatt ttgcgtttga cattgtgtct gggaaggaag ggccagacct tggaaccttt 1380 ggaacctgct gtcaacaggt cttacagggc tgcttgaacc ctcataggcc taggctttgg 1440 tctaaaagga acatttaaaa agttgccctg taaagttatt tggtgtcatt gaccaattgc 1500 atcccagcta aaaagcaaga ggcatcgttg cctggataat agaggatgtg tttcagccct 1560 gagatgttac agttgaagag cttggtttca ttgagcattt ctctattttt ccagttatcc 1620 cgaaatttct atgtattatt ttttggggaa gtgaggtgtg cccagttttt taatctaaca 1680 actacttttg gggacttgcc cacatctctg ggatttgaat ggggattgta tcccatttta 1740 ctgtctttta ggtttacatt taccacgttt ctcttctctg ctccccttgc ccactgggac 1800 tcctctttgg ctccttgaag tttgctgctt agagttggaa gtgcagcagg caggtgatca 1860 tgctgcaagt tctttctgga cctctggcaa agggagtggt cagtgaaggc catcgttacc 1920 ttgggatctg ccaggctggg gtgttttcgg tatctgctgt tcacagctct ccactgtaat 1980 ccgaatactt tgccagtgca ctaatctctt tggagataaa attcattagt gtgttactaa 2040 atgttaattt tcttttgcgg aaaatacagt accgtgtctg aattaattat taatatttaa 2100 aatacttcat tccttaactc tccctcattt gctttgccca cagcctattc agttcctttg 2160 tttggcagga ttctgcaaaa tgtgtctcac ccactactga gattgttcag cccctgatgt 2220 atttgtattg atttgtttct ggtggtagct tgtcctgaaa tgtgtgtaga aagcaagtat 2280 tttatgataa aaatgttgtg tagtgcatgc tctgtgtgga attcagagga aaacccagat 2340 tcagtgatta acaatgccaa aaaatgcaag taactagcca ttgttcaaat gacagtggtg 2400 ctatttctct tttgtggcct tttagacttt tgttgcccta aaattccatt ttattgggaa 2460 cccattttcc acctggtctt tcttgacagg gtttttttct actttaaaca gtttctaaat 2520 aaaattctgt atttcaaaaa 2540 <210> 3 <211> 1023 <212> DNA <213> Homo sapiens <400> 3 gttggctgcc ggtgagttgg gtgccggtgg agtcgtgttg gtcctcagaa tccccgcgta 60 gccgctgcct cctcctaccc tcgccatgtt tcttacccgg tctgagtacg acaggggcgt 120 gaatactttt tctcccgaag gaagattatt tcaagtggaa tatgccattg aggctatcaa 180 gcttggttct acagccattg ggatccagac atcagagggt gtgtgcctag ctgtggagaa 240 gagaattact tccccactga tggagcccag cagcattgag aaaattgtag agattgatgc 300 tcacataggt tgtgccatga gtgggctaat tgctgatgct aagactttaa ttgataaagc 360 cagagtggag acacagaacc actggttcac ctacaatgag acaatgacag tggagagtgt 420 gacccaagct gtgtccaatc tggctttgca gtttggagaa gaagatgcag atccaggtgc 480 catgtctcgt ccctttggag tagcattatt atttggagga gttgatgaga aaggacccca 540 gctgtttcat atggacccat ctgggacctt tgtacagtgt gatgctcgag caattggctc 600 tgcttcagag ggtgcccaga gctccttgca agaagtttac cacaagtcta tgactttgaa 660 agaagccatc aagtcttcac tcatcatcct caaacaagta atggaggaga agctgaatgc 720 aacaaacatt gagctagcca cagtgcagcc tggccagaat ttccacatgt tcacaaagga 780 agaacttgaa gaggttatca aggacattta aggaatcctg atcctcagaa cttctctggg 840 acaatttcag ttctaataat gtccttaaat tttatttcca gctcctgttc cttggaaaat 900 ctccattgta tgtgcatttt ttaaatgatg tctgtacata aaggcagttc tgaaataaag 960 aaaattttaa aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1020 aaa 1023 <210> 4 <211> 3309 <212> DNA <213> Homo sapiens <400> 4 ttcagcccct ctcccgggct gcgcctccgc actccgggcc cgggcagaag ggggtgcgcc 60 tcggccccac cacccaggga gcagccgagc tgaaaggccg ggaaccgcgg cttgcgggga 120 ccacagctcc cgaaagcgac gttcggccac cggaggagcg ggagccaagc aggcggagct 180 cggcgggaga ggtgcgggcc gaatccgagc cgagcggaga ggaatccggc agtagagagc 240 ggactccagc cggcggaccc tgcagccctc gcctgggaca gcggcgcgct gggcaggcgc 300 ccaagagagc atcgagcagc ggaacccgcg aagccggccc gcagccgcga cccgcgcagc 360 ctgccgctct cccgccgccg gtccgggcag catgaggcgc gcggcgctct ggctctggct 420 gtgcgcgctg gcgctgagcc tgcagccggc cctgccgcaa attgtggcta ctaatttgcc 480 ccctgaagat caagatggct ctggggatga ctctgacaac ttctccggct caggtgcagg 540 tgctttgcaa gatatcacct tgtcacagca gaccccctcc acttggaagg acacgcagct 600 cctgacggct attcccacgt ctccagaacc caccggcctg gaggctacag ctgcctccac 660 ctccaccctg ccggctggag aggggcccaa ggagggagag gctgtagtcc tgccagaagt 720 ggagcctggc ctcaccgccc gggagcagga ggccaccccc cgacccaggg agaccacaca 780 gctcccgacc actcatcagg cctcaacgac cacagccacc acggcccagg agcccgccac 840 ctcccacccc cacagggaca tgcagcctgg ccaccatgag acctcaaccc ctgcaggacc 900 cagccaagct gaccttcaca ctccccacac agaggatgga ggtccttctg ccaccgagag 960 ggctgctgag gatggagcct ccagtcagct cccagcagca gagggctctg gggagcagga 1020 cttcaccttt gaaacctcgg gggagaatac ggctgtagtg gccgtggagc ctgaccgccg 1080 gaaccagtcc ccagtggatc agggggccac gggggcctca cagggcctcc tggacaggaa 1140 agaggtgctg ggaggggtca ttgccggagg cctcgtgggg ctcatctttg ctgtgtgcct 1200 ggtgggtttc atgctgtacc gcatgaagaa gaaggacgaa ggcagctact ccttggagga 1260 gccgaaacaa gccaacggcg gggcctacca gaagcccacc aaacaggagg aattctatgc 1320 ctgacgcggg agccatgcgc cccctccgcc ctgccactca ctaggccccc acttgcctct 1380 tccttgaaga actgcaggcc ctggcctccc ctgccaccag gccacctccc cagcattcca 1440 gcccctctgg tcgctcctgc ccacggagtc gtggggtgtg ctgggagctc cactctgctt 1500 ctctgacttc tgcctggaga cttagggcac caggggtttc tcgcatagga cctttccacc 1560 acagccagca cctggcatcg caccattctg actcggtttc tccaaactga agcagcctct 1620 ccccaggtcc agctctggag gggaggggga tccgactgct ttggacctaa atggcctcat 1680 gtggctggaa gatcctgcgg gtggggcttg gggctcacac acctgtagca cttactggta 1740 ggaccaagca tcttgggggg gtggccgctg agtggcaggg gacaggagtc cactttgttt 1800 cgtggggagg tctaatctag atatcgactt gtttttgcac atgtttcctc tagttctttg 1860 ttcatagccc agtagacctt gttacttctg aggtaagtta agtaagttga ttcggtatcc 1920 ccccatcttg cttccctaat ctatggtcgg gagacagcat cagggttaag aagacttttt 1980 tttttttttt ttaaactagg agaaccaaat ctggaagcca aaatgtaggc ttagtttgtg 2040 tgttgtctct tgagtttgtc gctcatgtgt gcaacagggt atggactatc tgtctggtgg 2100 ccccgtttct ggtggtctgt tggcaggctg gccagtccag gctgccgtgg ggccgccgcc 2160 tctttcaagc agtcgtgcct gtgtccatgc gctcagggcc atgctgaggc ctgggccgct 2220 gccacgttgg agaagcccgt gtgagaagtg aatgctggga ctcagccttc agacagagag 2280 gactgtaggg agggcggcag gggcctggag atcctcctgc agaccacgcc cgtcctgcct 2340 gtggcgccgt ctccaggggc tgcttcctcc tggaaattga cgaggggtgt cttgggcaga 2400 gctggctctg agcgcctcca tccaaggcca ggttctccgt tagctcctgt ggccccaccc 2460 tgggccctgg gctggaatca ggaatatttt ccaaagagtg atagtctttt gcttttggca 2520 aaactctact taatccaatg ggtttttccc tgtacagtag attttccaaa tgtaataaac 2580 tttaatataa agtagtcctg tgaatgccac tgccttcgct tcttgcctct gtgctgtgtg 2640 tgacgtgacc ggacttttct gcaaacacca acatgttggg aaacttggct cgaatctctg 2700 tgccttcgtc tttcccatgg ggagggattc tggttccagg gtccctctgt gtatttgctt 2760 ttttgttttg gctgaaattc tcctggaggt cggtaggttc agccaaggtt ttataaggct 2820 gatgtcaatt tctgtgttgc caagctccaa gccccatctt ctaaatggca aaggaaggtg 2880 gatggcccca gcacagcttg acctgaggct gtggtcacag cggaggtgtg gagccgaggc 2940 ctaccccgca gacaccttgg acatcctcct cccacccggc tgcagaggcc agaggccccc 3000 agcccagggc tcctgcactt acttgcttat ttgacaacgt ttcagcgact ccgttggcca 3060 ctccgagagg tgggccagtc tgtggatcag agatgcacca ccaagccaag ggaacctgtg 3120 tccggtattc gatactgcga ctttctgcct ggagtgtatg actgcacatg actcgggggt 3180 ggggaaaggg gtcggctgac catgctcatc tgctggtccg tgggacggtg cccaagccag 3240 aggctgggtt catttgtgta acgacaataa acggtacttg tcatttcggg caaaaaaaaa 3300 aaaaaaaaa 3309 <210> 5 <211> 3217 <212> DNA <213> Homo sapiens <400> 5 ggccgggaga cctggcggag ctgggggtgg ggggccagtt tttgcaacgg ctaaggaagg 60 gcctgtgggt ttattataag gcggagctcg gcgggagagg tgcgggccga atccgagccg 120 agcggagagg aatccggcag tagagagcgg actccagccg gcggaccctg cagccctcgc 180 ctgggacagc ggcgcgctgg gcaggcgccc aagagagcat cgagcagcgg aacccgcgaa 240 gccggcccgc agccgcgacc cgcgcagcct gccgctctcc cgccgccggt ccgggcagca 300 tgaggcgcgc ggcgctctgg ctctggctgt gcgcgctggc gctgagcctg cagccggccc 360 tgccgcaaat tgtggctact aatttgcccc ctgaagatca agatggctct ggggatgact 420 ctgacaactt ctccggctca ggtgcaggtg ctttgcaaga tatcaccttg tcacagcaga 480 ccccctccac ttggaaggac acgcagctcc tgacggctat tcccacgtct ccagaaccca 540 ccggcctgga ggctacagct gcctccacct ccaccctgcc ggctggagag gggcccaagg 600 agggagaggc tgtagtcctg ccagaagtgg agcctggcct caccgcccgg gagcaggagg 660 ccaccccccg acccagggag accacacagc tcccgaccac tcatcaggcc tcaacgacca 720 cagccaccac ggcccaggag cccgccacct cccaccccca cagggacatg cagcctggcc 780 accatgagac ctcaacccct gcaggaccca gccaagctga ccttcacact ccccacacag 840 aggatggagg tccttctgcc accgagaggg ctgctgagga tggagcctcc agtcagctcc 900 cagcagcaga gggctctggg gagcaggact tcacctttga aacctcgggg gagaatacgg 960 ctgtagtggc cgtggagcct gaccgccgga accagtcccc agtggatcag ggggccacgg 1020 gggcctcaca gggcctcctg gacaggaaag aggtgctggg aggggtcatt gccggaggcc 1080 tcgtggggct catctttgct gtgtgcctgg tgggtttcat gctgtaccgc atgaagaaga 1140 aggacgaagg cagctactcc ttggaggagc cgaaacaagc caacggcggg gcctaccaga 1200 agcccaccaa acaggaggaa ttctatgcct gacgcgggag ccatgcgccc cctccgccct 1260 gccactcact aggcccccac ttgcctcttc cttgaagaac tgcaggccct ggcctcccct 1320 gccaccaggc cacctcccca gcattccagc ccctctggtc gctcctgccc acggagtcgt 1380 ggggtgtgct gggagctcca ctctgcttct ctgacttctg cctggagact tagggcacca 1440 ggggtttctc gcataggacc tttccaccac agccagcacc tggcatcgca ccattctgac 1500 tcggtttctc caaactgaag cagcctctcc ccaggtccag ctctggaggg gagggggatc 1560 cgactgcttt ggacctaaat ggcctcatgt ggctggaaga tcctgcgggt ggggcttggg 1620 gctcacacac ctgtagcact tactggtagg accaagcatc ttgggggggt ggccgctgag 1680 tggcagggga caggagtcca ctttgtttcg tggggaggtc taatctagat atcgacttgt 1740 ttttgcacat gtttcctcta gttctttgtt catagcccag tagaccttgt tacttctgag 1800 gtaagttaag taagttgatt cggtatcccc ccatcttgct tccctaatct atggtcggga 1860 gacagcatca gggttaagaa gacttttttt tttttttttt aaactaggag aaccaaatct 1920 ggaagccaaa atgtaggctt agtttgtgtg ttgtctcttg agtttgtcgc tcatgtgtgc 1980 aacagggtat ggactatctg tctggtggcc ccgtttctgg tggtctgttg gcaggctggc 2040 cagtccaggc tgccgtgggg ccgccgcctc tttcaagcag tcgtgcctgt gtccatgcgc 2100 tcagggccat gctgaggcct gggccgctgc cacgttggag aagcccgtgt gagaagtgaa 2160 tgctgggact cagccttcag acagagagga ctgtagggag ggcggcaggg gcctggagat 2220 cctcctgcag accacgcccg tcctgcctgt ggcgccgtct ccaggggctg cttcctcctg 2280 gaaattgacg aggggtgtct tgggcagagc tggctctgag cgcctccatc caaggccagg 2340 ttctccgtta gctcctgtgg ccccaccctg ggccctgggc tggaatcagg aatattttcc 2400 aaagagtgat agtcttttgc ttttggcaaa actctactta atccaatggg tttttccctg 2460 tacagtagat tttccaaatg taataaactt taatataaag tagtcctgtg aatgccactg 2520 ccttcgcttc ttgcctctgt gctgtgtgtg acgtgaccgg acttttctgc aaacaccaac 2580 atgttgggaa acttggctcg aatctctgtg ccttcgtctt tcccatgggg agggattctg 2640 gttccagggt ccctctgtgt atttgctttt ttgttttggc tgaaattctc ctggaggtcg 2700 gtaggttcag ccaaggtttt ataaggctga tgtcaatttc tgtgttgcca agctccaagc 2760 cccatcttct aaatggcaaa ggaaggtgga tggccccagc acagcttgac ctgaggctgt 2820 ggtcacagcg gaggtgtgga gccgaggcct accccgcaga caccttggac atcctcctcc 2880 cacccggctg cagaggccag aggcccccag cccagggctc ctgcacttac ttgcttattt 2940 gacaacgttt cagcgactcc gttggccact ccgagaggtg ggccagtctg tggatcagag 3000 atgcaccacc aagccaaggg aacctgtgtc cggtattcga tactgcgact ttctgcctgg 3060 agtgtatgac tgcacatgac tcgggggtgg ggaaaggggt cggctgacca tgctcatctg 3120 ctggtccgtg ggacggtgcc caagccagag gctgggttca tttgtgtaac gacaataaac 3180 ggtacttgtc atttcgggca aaaaaaaaaa aaaaaaa 3217 <210> 6 <211> 4369 <212> DNA <213> Homo sapiens <400> 6 gtcccaggcg gttccgctca acagacgctg ctgtggctgc gccgggctgc gacactgcag 60 ttgtctacgc ggccggggcc gggacgagga ggcgttggac ggggtcgcat acgttcgtcc 120 cctcgcattg cggccccgac agctgcgcca ggatccccgg gcggcggcgc ggggcgtgaa 180 cgctctgggg ctcagccagg cctgcgcggg cccgaggccg gaggaacccg gactccggcg 240 tagcggtttt gacacaaggg cgcatatctt caaagcacct agtacctcct accattgtca 300 actgatacag aattcgttgt tgggaaggac tggggaaaca gctgtaacat ttgccaccct 360 cagaagctgc tggtcctgtg tcacaccacc ttagcctctt gatcgaggaa gattctcgct 420 gaagtctgtt aattctactt tttgagtact tatgaataac cacgtgtctt caaaaccatc 480 taccatgaag ctaaaacata ccatcaaccc tattctttta tattttatac attttctaat 540 atcactttat actattttaa catacattcc gttttatttt ttctccgagt caagacaaga 600 aaaatcaaac cgaattaaag caaagcctgt aaattcaaaa cctgattctg catacagatc 660 tgttaatagt ttggatggtt tggcttcagt attataccct ggatgtgata ctttagataa 720 agtttttaca tatgcaaaaa acaaatttaa gaacaaaaga ctcttgggaa cacgtgaagt 780 tttaaatgag gaagatgaag tacaaccaaa tggaaaaatt tttaaaaagg ttattcttgg 840 acagtataat tggctttcct atgaagatgt ctttgttcga gcctttaatt ttggaaatgg 900 attacagatg ttgggtcaga aaccaaagac caacatcgcc atcttctgtg agaccagggc 960 cgagtggatg atagctgcac aggcgtgttt tatgtataat tttcagcttg ttacattata 1020 tgccactcta ggaggtccag ccattgttca tgcattaaat gaaacagagg tgaccaacat 1080 cattactagt aaagaactct tacaaacaaa gttgaaggat atagtttctt tggtcccacg 1140 cctgcggcac atcatcactg ttgatggaaa gccaccgacc tggtccgagt tccccaaggg 1200 catcattgtg cataccatgg ctgcagtgga ggccctggga gccaaggcca gcatggaaaa 1260 ccaacctcat agcaaaccat tgccctcaga tattgcagta atcatgtaca caagtggatc 1320 cacaggactt ccaaagggag tcatgatctc acatagtaac attattgctg gtataactgg 1380 gatggcagaa aggattccag aactaggaga ggaagatgtc tacattggat atttgcctct 1440 ggcccatgtt ctagaattaa gtgctgagct tgtctgtctt tctcacggat gccgcattgg 1500 ttactcttca ccacagactt tagcagatca gtcttcaaaa attaaaaaag gaagcaaagg 1560 ggatacatcc atgttgaaac caacactgat ggcagcagtt ccggaaatca tggatcggat 1620 ctacaaaaat gtcatgaata aagtcagtga aatgagtagt tttcaacgta atctgtttat 1680 tctggcctat aattacaaaa tggaacagat ttcaaaagga cgtaatactc cactgtgcga 1740 cagctttgtt ttccggaaag ttcgaagctt gctaggggga aatattcgtc tcctgttgtg 1800 tggtggcgct ccactttctg caaccacgca gcgattcatg aacatctgtt tctgctgtcc 1860 tgttggtcag ggatacgggc tcactgaatc tgctggggct ggaacaattt ccgaagtgtg 1920 ggactacaat actggcagag tgggagcacc attagtttgc tgtgaaatca aattaaaaaa 1980 ctgggaggaa ggtggatact ttaatactga taagccacac cccaggggtg aaattcttat 2040 tgggggccaa agtgtgacaa tggggtacta caaaaatgaa gcaaaaacaa aagctgattt 2100 ctttgaagat gaaaatggac aaaggtggct ctgtactggg gatattggag agtttgaacc 2160 cgatggatgc ttaaagatta ttgatcgtaa aaaggacctt gtaaaactac aggcagggga 2220 atatgtttct cttgggaaag tagaggcagc tttgaagaat cttccactag tagataacat 2280 ttgtgcatat gcaaacagtt atcattctta tgtcattgga tttgttgtgc caaatcaaaa 2340 ggaactaact gaactagctc gaaagaaagg acttaaaggg acttgggagg agctgtgtaa 2400 cagttgtgaa atggaaaatg aggtacttaa agtgctttcc gaagctgcta tttcagcaag 2460 tctggaaaag tttgaaattc cagtaaaaat tcgtttgagt cctgaaccgt ggacccctga 2520 aactggtctg gtgacagatg ccttcaagct gaaacgcaaa gagcttaaaa cacattacca 2580 ggcggacatt gagcgaatgt atggaagaaa ataattattc tcttctggca tcagtttgct 2640 acagtgagct cagatcaaat aggaaaatac ttgaaatgca tgtctcaagc tgcaaggcaa 2700 actccattcc tcatattaaa ctattacttc tcatgacgtc accattttta actgacagga 2760 ttagtaaaac attaagacag caaacttgtg tctgtctctt ctttcatttt ccccgccacc 2820 aacttacttt accacctatg actgtacttg tcagtatgag aatttttctg aatcatattg 2880 gggaagcagt gattttaaaa cctcaagttt ttaaacatga tttatatgtt ctgtataatg 2940 ttcagtttgt aactttttaa aagtttggat gtatagaggg ataaatagga aatataagaa 3000 ttggttattt gggggctttt ttacttactg tatttaaaaa tacaagggta ttgatatgaa 3060 attatgtaaa tttcaaatgc ttatgaatca aatcattgtt gaacaaaaga tttgttgctg 3120 tgtaattatt gtcttgtatg catttgagag aaataaatat acccatactt atgttttaag 3180 aagttgagat cttgtgaata tatgcctgtc agtgtcttct ttatatattt attttttatt 3240 agaaaaaatg aagtttggtt ggtgatgcat gaaacaaaat agcaagagag ggttatagtt 3300 taatagtaag ggagataaca cagcatgtgt agcaccagtt gataattggt ctctagtagc 3360 ttactgtcaa aatgttcaat gaagtcttct gttcatctgt tgaaactagg aaaataccca 3420 aacttaaatg gaagaattct gaaagagagg atagaattta aagaacaaga gtatataaag 3480 ttattctttg aatatttcgt tgactatatg tacattgagt tatctatatt tgtaaacaaa 3540 ttagtcatgg aaaattattc tatctcaaag tctcctttta gtctagataa tcattatttc 3600 attttaaaat tagtgttttt cctagtttgc actgatgcgt gtatggatgt gtgtgagtca 3660 gtggtagctt atttaaaaag caccttatcc tttctcccat aacctttgta cactaaaaaa 3720 tgaaagaatt tagaatgtat ttgatgatag cattctcact aagacacatg agaatttaac 3780 tttataaccg cgtgagttaa gatttaattc ataggttttg atgtcattgt tgaagttatt 3840 tgtaattcag aaaccttgct tgtgtgatac atagtctctt catttattac tgcttgtctg 3900 ttgttatatc tggattatca aaagcaatag tgcaccaatt aagatgtgct caaatcagga 3960 cttaaatcat aggcaccaca tttttcatgt cagactagtt actttgttga ttctcagtta 4020 ctgtaggcat caaaaggcaa aaatcaaaaa aaaaaaaaac aaaaacaaaa aaaaagatga 4080 acctaggtct gtgtaaagta aggggagtgt taggagcagc caggactgtg tagtgtgtgt 4140 ttggttgcat cacaaacatc gtatgtggag acattgcaat acagtgtttt ttgttttcaa 4200 cttttcttgt attgtatatt tgtattatgt tttgaatgct tttctctttt cataattaaa 4260 tattaatgtt tgggataact gccaagaaga agtaaaaata ttgaatggaa cttctatatg 4320 aggatgctgt gatctaaaaa ttaaatctca gtgggcggag aaaaaaaaa 4369 <210> 7 <211> 4262 <212> DNA <213> Homo sapiens <400> 7 gtcccaggcg gttccgctca acagacgctg ctgtggctgc gccgggctgc gacactgcag 60 ttgtctacgc ggccggggcc gggacgagga ggcgttggac ggggtcgcat acgttcgtcc 120 cctcgcattg cggccccgac agctgcgcca ggatccccgg gcggcggcgc ggggcgtgaa 180 cgctctgggg ctcagccagg cctgcgcggg cccgaggccg gaggaacccg gactccggcg 240 tagcggtttt gacacaaggg cgcatatctt caaagcacct agtacctcct accattgtca 300 actgattctc gctgaagtct gttaattcta ctttttgagt acttatgaat aaccacgtgt 360 cttcaaaacc atctaccatg aagctaaaac ataccatcaa ccctattctt ttatatttta 420 tacattttct aatatcactt tatactattt taacatacat tccgttttat tttttctccg 480 agtcaagaca agaaaaatca aaccgaatta aagcaaagcc tgtaaattca aaacctgatt 540 ctgcatacag atctgttaat agtttggatg gtttggcttc agtattatac cctggatgtg 600 atactttaga taaagttttt acatatgcaa aaaacaaatt taagaacaaa agactcttgg 660 gaacacgtga agttttaaat gaggaagatg aagtacaacc aaatggaaaa atttttaaaa 720 aggttattct tggacagtat aattggcttt cctatgaaga tgtctttgtt cgagccttta 780 attttggaaa tggattacag atgttgggtc agaaaccaaa gaccaacatc gccatcttct 840 gtgagaccag ggccgagtgg atgatagctg cacaggcgtg ttttatgtat aattttcagc 900 ttgttacatt atatgccact ctaggaggtc cagccattgt tcatgcatta aatgaaacag 960 aggtgaccaa catcattact agtaaagaac tcttacaaac aaagttgaag gatatagttt 1020 ctttggtccc acgcctgcgg cacatcatca ctgttgatgg aaagccaccg acctggtccg 1080 agttccccaa gggcatcatt gtgcatacca tggctgcagt ggaggccctg ggagccaagg 1140 ccagcatgga aaaccaacct catagcaaac cattgccctc agatattgca gtaatcatgt 1200 acacaagtgg atccacagga cttccaaagg gagtcatgat ctcacatagt aacattattg 1260 ctggtataac tgggatggca gaaaggattc cagaactagg agaggaagat gtctacattg 1320 gatatttgcc tctggcccat gttctagaat taagtgctga gcttgtctgt ctttctcacg 1380 gatgccgcat tggttactct tcaccacaga ctttagcaga tcagtcttca aaaattaaaa 1440 aaggaagcaa aggggataca tccatgttga aaccaacact gatggcagca gttccggaaa 1500 tcatggatcg gatctacaaa aatgtcatga ataaagtcag tgaaatgagt agttttcaac 1560 gtaatctgtt tattctggcc tataattaca aaatggaaca gatttcaaaa ggacgtaata 1620 ctccactgtg cgacagcttt gttttccgga aagttcgaag cttgctaggg ggaaatattc 1680 gtctcctgtt gtgtggtggc gctccacttt ctgcaaccac gcagcgattc atgaacatct 1740 gtttctgctg tcctgttggt cagggatacg ggctcactga atctgctggg gctggaacaa 1800 tttccgaagt gtgggactac aatactggca gagtgggagc accattagtt tgctgtgaaa 1860 tcaaattaaa aaactgggag gaaggtggat actttaatac tgataagcca caccccaggg 1920 gtgaaattct tattgggggc caaagtgtga caatggggta ctacaaaaat gaagcaaaaa 1980 caaaagctga tttctttgaa gatgaaaatg gacaaaggtg gctctgtact ggggatattg 2040 gagagtttga acccgatgga tgcttaaaga ttattgatcg taaaaaggac cttgtaaaac 2100 tacaggcagg ggaatatgtt tctcttggga aagtagaggc agctttgaag aatcttccac 2160 tagtagataa catttgtgca tatgcaaaca gttatcattc ttatgtcatt ggatttgttg 2220 tgccaaatca aaaggaacta actgaactag ctcgaaagaa aggacttaaa gggacttggg 2280 aggagctgtg taacagttgt gaaatggaaa atgaggtact taaagtgctt tccgaagctg 2340 ctatttcagc aagtctggaa aagtttgaaa ttccagtaaa aattcgtttg agtcctgaac 2400 cgtggacccc tgaaactggt ctggtgacag atgccttcaa gctgaaacgc aaagagctta 2460 aaacacatta ccaggcggac attgagcgaa tgtatggaag aaaataatta ttctcttctg 2520 gcatcagttt gctacagtga gctcagatca aataggaaaa tacttgaaat gcatgtctca 2580 agctgcaagg caaactccat tcctcatatt aaactattac ttctcatgac gtcaccattt 2640 ttaactgaca ggattagtaa aacattaaga cagcaaactt gtgtctgtct cttctttcat 2700 tttccccgcc accaacttac tttaccacct atgactgtac ttgtcagtat gagaattttt 2760 ctgaatcata ttggggaagc agtgatttta aaacctcaag tttttaaaca tgatttatat 2820 gttctgtata atgttcagtt tgtaactttt taaaagtttg gatgtataga gggataaata 2880 ggaaatataa gaattggtta tttgggggct tttttactta ctgtatttaa aaatacaagg 2940 gtattgatat gaaattatgt aaatttcaaa tgcttatgaa tcaaatcatt gttgaacaaa 3000 agatttgttg ctgtgtaatt attgtcttgt atgcatttga gagaaataaa tatacccata 3060 cttatgtttt aagaagttga gatcttgtga atatatgcct gtcagtgtct tctttatata 3120 tttatttttt attagaaaaa atgaagtttg gttggtgatg catgaaacaa aatagcaaga 3180 gagggttata gtttaatagt aagggagata acacagcatg tgtagcacca gttgataatt 3240 ggtctctagt agcttactgt caaaatgttc aatgaagtct tctgttcatc tgttgaaact 3300 aggaaaatac ccaaacttaa atggaagaat tctgaaagag aggatagaat ttaaagaaca 3360 agagtatata aagttattct ttgaatattt cgttgactat atgtacattg agttatctat 3420 atttgtaaac aaattagtca tggaaaatta ttctatctca aagtctcctt ttagtctaga 3480 taatcattat ttcattttaa aattagtgtt tttcctagtt tgcactgatg cgtgtatgga 3540 tgtgtgtgag tcagtggtag cttatttaaa aagcacctta tcctttctcc cataaccttt 3600 gtacactaaa aaatgaaaga atttagaatg tatttgatga tagcattctc actaagacac 3660 atgagaattt aactttataa ccgcgtgagt taagatttaa ttcataggtt ttgatgtcat 3720 tgttgaagtt atttgtaatt cagaaacctt gcttgtgtga tacatagtct cttcatttat 3780 tactgcttgt ctgttgttat atctggatta tcaaaagcaa tagtgcacca attaagatgt 3840 gctcaaatca ggacttaaat cataggcacc acatttttca tgtcagacta gttactttgt 3900 tgattctcag ttactgtagg catcaaaagg caaaaatcaa aaaaaaaaaa aacaaaaaca 3960 aaaaaaaaga tgaacctagg tctgtgtaaa gtaaggggag tgttaggagc agccaggact 4020 gtgtagtgtg tgtttggttg catcacaaac atcgtatgtg gagacattgc aatacagtgt 4080 tttttgtttt caacttttct tgtattgtat atttgtatta tgttttgaat gcttttctct 4140 tttcataatt aaatattaat gtttgggata actgccaaga agaagtaaaa atattgaatg 4200 gaacttctat atgaggatgc tgtgatctaa aaattaaatc tcagtgggcg gagaaaaaaa 4260 aa 4262 <210> 8 <211> 1906 <212> DNA <213> Homo sapiens <400> 8 ggcgccgccg ccgctcccga ggcccctgcc gccgccgctc ccgctgctgt cgccgcgcag 60 agccggagca ggagccacgg ccgagaggag ggaggaggag gaggaggagg tggaggaggt 120 ggaggaggtg gaggaggcgc cggaccgggg gggatagatt cccagaagtg ggataactgg 180 atcagagggt gattaccctg tgtataagag tatgtgtctc actgcacctt caatggcatt 240 gagtagatcg tcagtattta aacagatcac atcatgcgtg agtacaagct agtggtcctt 300 ggttcaggag gcgttgggaa gtctgctctg acagttcagt ttgttcaggg aatttttgtt 360 gaaaaatatg acccaacgat agaagattcc tacagaaagc aagttgaagt cgattgccaa 420 cagtgtatgc tcgaaatcct ggatactgca gggacagagc aatttacagc aatgagggat 480 ttgtatatga agaacggcca aggttttgca ctagtatatt ctattacagc tcagtccacg 540 tttaacgact tacaggacct gagggaacag attttacggg ttaaggacac ggaagatgtt 600 ccaatgattt tggttggcaa taaatgtgac ctggaagatg agcgagtagt tggcaaagag 660 cagggccaga atttagcaag acagtggtgt aactgtgcct ttttagaatc ttctgcaaag 720 tcaaagatca atgttaatga gatattttat gacctggtca gacagataaa taggaaaaca 780 ccagtggaaa agaagaagcc taaaaagaaa tcatgtctgc tgctctaggc ccatagtcag 840 cagcagctct gagccagatt acaggaatga agaactgttg cctaattgga aagtgccagc 900 attccagact tcaaaaataa aaaatctgaa gaggcttctc ctgttttata tattatgtga 960 agaatttaga tcttatattg gtttgcacaa gttccctgga gaaaaaaatt gctctgtgta 1020 tatctcttgg aaaataagac aatagtattt ctcctttgca atagcagtta taacagatgt 1080 gaaaatatac ttgactctaa tatgattata caaaagagca tggatgcatt tcaaatgtta 1140 gatattgcta ctataatcaa atgatttcat attgatcttt ttatcatgat cctccctatc 1200 aagcactaaa aagttgaacc attatacttt atatctgtaa tgatactgat tatgaaatgt 1260 cccctcaaac tcattgcagc agataacttt tttgagtcat tgacttcatt ttatatttaa 1320 aaaattatgg aatatcatct gtcattatat tctaattaaa attgtgcata atgctttgga 1380 aaaatgggtc ttttatagga aaaaaactgg gataactgat ttctatggct ttcaaagcta 1440 aaatatataa tatactaaac caactctaat attgcttctt gtgttttact gtcagattaa 1500 attacagctt ttatggatga ttaaatttta gtacattttc atttggtttg tgtgtttttg 1560 ttattgttta tagattaaag cgtttatttt ataatgacca cattgtttta aatgcgacag 1620 tagctccttt ctgcctagta tctgcagaac actggcttta aactatacta agtaactggt 1680 gatttctcta ggaacagacc tcgcactttc tgttctaaat atatttattc ctactataca 1740 gtaaaataca tcagacaaca tagaatagtt ttgtatattc tctcttgatc ttaaagattg 1800 tatcttattg aatatcccac tgtatattat ttttatatgt aaaaagataa gtttaatact 1860 gtatcagggt ttaactttta ctatttcaga tcttccacag cttgta 1906 <210> 9 <211> 1812 <212> DNA <213> Homo sapiens <400> 9 ggcgccgccg ccgctcccga ggcccctgcc gccgccgctc ccgctgctgt cgccgcgcag 60 agccggagca ggagccacgg ccgagaggag ggaggaggag gaggaggagg tggaggaggt 120 ggaggaggtg gaggaggcgc cggaccgggg ggatcgtcag tatttaaaca gatcacatca 180 tgcgtgagta caagctagtg gtccttggtt caggaggcgt tgggaagtct gctctgacag 240 ttcagtttgt tcagggaatt tttgttgaaa aatatgaccc aacgatagaa gattcctaca 300 gaaagcaagt tgaagtcgat tgccaacagt gtatgctcga aatcctggat actgcaggga 360 cagagcaatt tacagcaatg agggatttgt atatgaagaa cggccaaggt tttgcactag 420 tatattctat tacagctcag tccacgttta acgacttaca ggacctgagg gaacagattt 480 tacgggttaa ggacacggaa gatgttccaa tgattttggt tggcaataaa tgtgacctgg 540 aagatgagcg agtagttggc aaagagcagg gccagaattt agcaagacag tggtgtaact 600 gtgccttttt agaatcttct gcaaagtcaa agatcaatgt taatgagata ttttatgacc 660 tggtcagaca gataaatagg aaaacaccag tggaaaagaa gaagcctaaa aagaaatcat 720 gtctgctgct ctaggcccat agtcagcagc agctctgagc cagattacag gaatgaagaa 780 ctgttgccta attggaaagt gccagcattc cagacttcaa aaataaaaaa tctgaagagg 840 cttctcctgt tttatatatt atgtgaagaa tttagatctt atattggttt gcacaagttc 900 cctggagaaa aaaattgctc tgtgtatatc tcttggaaaa taagacaata gtatttctcc 960 tttgcaatag cagttataac agatgtgaaa atatacttga ctctaatatg attatacaaa 1020 agagcatgga tgcatttcaa atgttagata ttgctactat aatcaaatga tttcatattg 1080 atctttttat catgatcctc cctatcaagc actaaaaagt tgaaccatta tactttatat 1140 ctgtaatgat actgattatg aaatgtcccc tcaaactcat tgcagcagat aacttttttg 1200 agtcattgac ttcattttat atttaaaaaa ttatggaata tcatctgtca ttatattcta 1260 attaaaattg tgcataatgc tttggaaaaa tgggtctttt ataggaaaaa aactgggata 1320 actgatttct atggctttca aagctaaaat atataatata ctaaaccaac tctaatattg 1380 cttcttgtgt tttactgtca gattaaatta cagcttttat ggatgattaa attttagtac 1440 attttcattt ggtttgtgtg tttttgttat tgtttataga ttaaagcgtt tattttataa 1500 tgaccacatt gttttaaatg cgacagtagc tcctttctgc ctagtatctg cagaacactg 1560 gctttaaact atactaagta actggtgatt tctctaggaa cagacctcgc actttctgtt 1620 ctaaatatat ttattcctac tatacagtaa aatacatcag acaacataga atagttttgt 1680 atattctctc ttgatcttaa agattgtatc ttattgaata tcccactgta tattattttt 1740 atatgtaaaa agataagttt aatactgtat cagggtttaa cttttactat ttcagatctt 1800 ccacagcttg ta 1812 <210> 10 <211> 3915 <212> DNA <213> Homo sapiens <400> 10 gtggggtggg gtggggctgg gggcttgtcg ccctttcagg ctccaccctt tgcggagatt 60 ataaatagtc atgatcccag cgagacccag agatgcctgt aatggtgaga ctttggatcc 120 ttcctgagga cgtggagaaa actttctgct gagaaggaca ttttgaaggt tttgttggct 180 gaaaaagctg tttctggaat cacccctaga tctttcttga agacttgaat tagattacag 240 cgatggggac acagaaggtc accccagctc tgatatttgc catcacagtt gctacaatcg 300 gctctttcca atttggctac aacactgggg tcatcaatgc tcctgagaag atcataaagg 360 aatttatcaa taaaactttg acggacaagg gaaatgcccc accctctgag gtgctgctca 420 cgtctctctg gtccttgtct gtggccatat tttccgtcgg gggtatgatc ggctcctttt 480 ccgtcggact cttcgtcaac cgctttggca ggcgcaattc aatgctgatt gtcaacctgt 540 tggctgtcac tggtggctgc tttatgggac tgtgtaaagt agctaagtcg gttgaaatgc 600 tgatcctggg tcgcttggtt attggcctct tctgcggact ctgcacaggt tttgtgccca 660 tgtacattgg agagatctcg cctactgccc tgcggggtgc ctttggcact ctcaaccagc 720 tgggcatcgt tgttggaatt ctggtggccc agatctttgg tctggaattc atccttgggt 780 ctgaagagct atggccgctg ctactgggtt ttaccatcct tcctgctatc ctacaaagtg 840 cagcccttcc attttgccct gaaagtccca gatttttgct cattaacaga aaagaagagg 900 agaatgctaa gcagatcctc cagcggttgt ggggcaccca ggatgtatcc caagacatcc 960 aggagatgaa agatgagagt gcaaggatgt cacaagaaaa gcaagtcacc gtgctagagc 1020 tctttagagt gtccagctac cgacagccca tcatcatttc cattgtgctc cagctctctc 1080 agcagctctc tgggatcaat gctgtgttct attactcaac aggaatcttc aaggatgcag 1140 gtgttcaaga gcccatctat gccaccatcg gcgcgggtgt ggttaatact atcttcactg 1200 tagtttctct atttctggtg gaaagggcag gaagaaggac tctgcatatg ataggccttg 1260 gagggatggc tttttgttcc acgctcatga ctgtttcttt gttattaaag gataactata 1320 atgggatgag ctttgtctgt attggggcta tcttggtctt tgtagccttc tttgaaattg 1380 gaccaggccc cattccctgg tttattgtgg ccgaactctt cagccagggc ccccgcccag 1440 ctgcgatggc agtggccggc tgctccaact ggacctccaa cttcctagtc ggattgctct 1500 tcccctccgc tgctcactat ttaggagcct acgtttttat tatcttcacc ggcttcctca 1560 ttaccttctt ggcttttacc ttcttcaaag tccctgagac ccgtggcagg acttttgagg 1620 atatcacacg ggcctttgaa gggcaggcac acggtgcaga tagatctgga aaggacggcg 1680 tcatggagat gaacagcatc gagcctgcta aggagaccac caccaatgtc taagtcgtgc 1740 ctccttccac ctccctcccg gcatgggaaa gccacctctc cctcaacaag ggagagacct 1800 catcaggatg aacccaggac gcttctgaat gctgctactt aattcctttc tcatcccacg 1860 cactccatga gcaccccaag gctgcggttt gttggatctt caatggcttt ttaaatttta 1920 tttcctggac atcctcttct gcttaggaga gaccgagtga acctaccttc atttcaggag 1980 ggattggccg cttggcacat gacaactttg ccagcttttc ctcccttggg ttctgatatt 2040 gccgcactag gggatatagg agaggaaaag taaggtgcag ttcccccaac ctcagactta 2100 ccaggaagca gatacatatg agtgtggaag ccggagggtg tttatgtaag agcaccttcc 2160 tcacttccat acagctctac gtggcaaatt aacttgagtt ttatttattt tatcctctgg 2220 tttaattaca taattttttt ttttttactt taagtttcag gatacatgtg ccgaatgtgc 2280 aggtttgtta cataggtata tatatgccat gatggaaata tttatttttt taagcgtaat 2340 tttgccaaat aataaaaaca gaaggaaatt gagattagag ggaggtgttt aaagagaggt 2400 tatagagtag aagatttgat gctggagagg ttaaggtgca ataagaattt agggagaaat 2460 gttgttcatt attggagggt aaatgatgtg gtgcctgagg tctgtacgtt acctcttaac 2520 aatttctgtc cttcagatgg aaactcttta acttctcgta aaagtcatat acctatataa 2580 taaagctact gatttccttg gagctttttt ctttaagata atagtttaca tgtagtagta 2640 cttgaaatct aggattatta actaatatgg gcattgtagt taatgatggt tgatgggttc 2700 taattttgga tggagtccag ggaagagaaa gtgatttcta gaaagcctgt tcccctcact 2760 ggatgaaata actccttctt gtagtagtct cattactttt gaagtaatcc cgccacctat 2820 ctcgtgggag agccatccaa ataagaaacc taaaataatt ggttcttggt agagattcat 2880 tatttttcca ctttgttctt taggagattt taggtgttga ttttctgttg tattttaact 2940 cataccttta aaggaattcc ccaaagaatg tttatagcaa acttggaatt tgtaacctca 3000 gctctgggag aggatttttt tctgagcgat tattatctaa agtgtgttgt tgctttaggc 3060 tcacggcacg cttgcgtatg tctgttacca tgtcactgtg gtcctatgcc gaatgccctc 3120 aggggacttg aatctttcca ataaaccagg tttagacagt atgagtcaat gtgcagtgta 3180 gcccacactt gagaggatga atgtatgtgc actgtcactt tgctctgggt ggaagtacgt 3240 tattgttgac ttattttctc tgtgtttgtt cctacagccc ctttttcata tgttgctcag 3300 tctccctttc ccttcttggt gcttacacat ctcagaccct ttagccaaac ccttgtcagt 3360 gacagtattt tggttcttag ttctcactgt tccctctgct cctggagcct ttgaataaaa 3420 atgcacgtag ctgaggccgg atgcggtggc tcacgcctgt aatcccagca ctttgggagg 3480 cctaggcggg cggtcagggg ttcgagacca gtctggccaa catcgtgaaa ccctgtctct 3540 actaaaaatg caaaaattag ccgggcgtgg tggcgggcgc ctgtaatccc agctacttgg 3600 gaagctgagg cgggagaatc atgtgaaccc gggacgcagg ggttgcagtg agcggagatc 3660 gcatcattgc actctagcct gggccacagg gcgagactcc gtctcaaaaa aaaaaaaatg 3720 cacatagcta tcgagtgtgc tttagcttga aaaggtgacc ttgcaacttc atgtcaactt 3780 tctggctcct caaacagtag gttggcagta aggcagggtc ccatttctca ctgagaagat 3840 tgtgaatatt tccatatgga ttttctattg ttactctggt tctttgtttt aaaataaaaa 3900 ttctgaatgt acacg 3915 <210> 11 <211> 2410 <212> DNA <213> Homo sapiens <400> 11 gtccttttcc tcctgtcctt tgccagcgtt gggccggacc gggccgagcc gggccgcccg 60 ggcgcagtct ttaaccatgg cgtccctctt caagaagaaa accgtggatg atgtaataaa 120 ggaacagaat cgagagttac gaggtacaca gagggctata atcagagatc gagcagcttt 180 agagaaacaa gaaaaacagc tggaattaga aattaagaaa atggccaaga ttggtaataa 240 ggaagcttgc aaagttttag ccaaacaact tgtgcatcta cggaaacaga agacgagaac 300 ttttgctgta agttcaaaag ttacttctat gtctacacaa acaaaagtga tgaattccca 360 aatgaagatg gctggagcaa tgtctaccac agcaaaaaca atgcaggcag ttaacaagaa 420 gatggatcca caaaagacat tacaaacaat gcagaatttc cagaaggaaa acatgaaaat 480 ggaaatgact gaagaaatga tcaatgatac acttgatgac atctttgacg gttctgatga 540 cgaagaagaa agccaggata ttgtgaatca agttcttgat gaaattggaa ttgaaatttc 600 tggaaagatg gccaaagctc catcagctgc tcgaagctta ccatctgcct ctacttcaaa 660 ggctacaatc tcagatgaag agattgaacg gcaactcaag gctttaggag tagattagtc 720 aaaagaagtc atactatttt gcttacttat aattatgtag tataaaccaa gcacagtgca 780 gatttctttt acaaaacaca tgtattttgc aaaaaaaaaa aaaatgaaga ccatgagtga 840 acagttgttt cctaacccat ggctatttag aatcttttgc caaagaatga caatgatgca 900 aaaatgggaa cagtttggat tttaattaga actgtttagg agtgatgatg tgtaaaaagt 960 tgacttctct tttgcatggc acagagaaat tatattcctt acttcatgtc agtttatgtt 1020 ctaaatcttt ttcactgaat ataaaaatct tgttaaatgc cattaggcac caacttaaag 1080 agggttgtaa aaatattaaa agtatatcgt taattctgta tctgttgctt gtcttttgta 1140 agtgattatg tgttatgacc ataggtggtt acagctgcca aattattttt aaatggtcaa 1200 aaagaagagt gctatttaaa catctgtctt aaacaaaaac tgtcataact tttctttttt 1260 ctttttccat taggagaaca ttctagttgg taaatttcaa aatgtgcttg acacctgcct 1320 taaatagcac agacctattg tgcacatctt taaattattt cagctggcag aaaagaatta 1380 catttaaaac tgaaatcaag gcctcaatac aaagattatc ctggctcttt tctatctctg 1440 tgggcctaat tgaaatatgt actcttattt tagacacgcc tctgttaaaa cagaccaggt 1500 tttcctggtc tcagacctat gatgacttgt ccctttgatg tcactactgt gaattgaata 1560 taattagtaa aaatagacga tgaataaata acactttata gtaagaaaac aatatatttt 1620 ggccatctaa aaatgagaat tataattata tgaattataa tttaaactgt ttaattttgt 1680 ttaatgtgta tattgaatct tccaaattga agccattatt ctcaattaag tactacaact 1740 atgacaatgc ttgacctaca tttctaaaat aaaaattcac attttttgat aaataaacta 1800 cagttttacc agaaattact atctaaatgt gtattagcag tattttttaa ggtgaaattg 1860 ccttggtatc taatgaatgt gtagacaggg agataaaatg aaggattgcc agactagtta 1920 gaatagaatt taggattagg ttagttttga aaaatgatgt tgtaatatat gggttctaac 1980 acatcctacc ataaaaactg gaggagatat gtgtaacctg gttaatttgg gatggtggac 2040 attttgggct aatactgaca aaatacatct taggactagt atacatgtga cacggattgc 2100 taggaggaat gaaaaactaa actgtatagt ttatattccg taaaccattt tataatgttc 2160 aaagattagg ttttgttatt gatagtatta aatacacagt ttctcttaac agtgatgggt 2220 gaaaacattt taccggatta tggaatgttt accagaacat gttttgattc ttgaatgtac 2280 ataataatgc catctaactt atttacattc ttgtttacat gtgggagctt ttgttttcaa 2340 aaattatttt gttaaaaaat ctcaataaag atttattatt gttgttcttt tcttaaaaaa 2400 aaaaaaaaaa 2410 <210> 12 <211> 2718 <212> DNA <213> Homo sapiens <400> 12 gggctcgagg cgttcggctg aggaagggag cgcacgccgg cggcgcggag gccggctctg 60 cgcttcgggc cgccccctcc ccccaccccg ctcacacccg gcacttactt cggctgtctc 120 cgctgccctc cagcggagac gcagctcctc aggcgcccgg cggtatttgt tgggtcggcg 180 gcgtcaggga ttcgcagtgg cctgtggtcg gcgtcgtccg gccactggtg cgcccccgcg 240 gcaggcagag ctcacgctcc tgtcccccgg ctggtccggg gtctgggcgc cgcgtcgacg 300 gcggctccgc aggacgcgca gaccgggccg cagcccatgc cccgagcgga ctgcattatg 360 aggcacctgc cttacttctg ccggggtcaa gtggtgcggg gcttcggccg cggctccaag 420 cagctgggca tccccacagc taattttcct gagcaagtgg tagataatct tccagctgat 480 atatccactg gtatttacta tggttgggcc agtgttggaa gtggagatgt ccataagatg 540 gtggtgagca taggatggaa cccatattac aagaatacga agaagtctat ggaaacacat 600 atcatgcata ccttcaaaga ggacttctat ggggaaatcc tcaatgtggc cattgttggc 660 tacctgagac cagaaaagaa ctttgattct ttagagtcac ttatttcagc aattcaaggt 720 gatattgaag aagctaagaa acgactagag ttaccagaac atttgaaaat caaagaagac 780 aatttcttcc aggtttctaa aagcaaaata atgaatggcc actgatgaaa aattgtatta 840 tttattcatt cactgttttc tagtgtttct gtgtttatta ctgttcagca tcatcttggt 900 tatatactga aaatcaaaca ctttactaca gttgtgaatt agtttaaacc gtacaatgtt 960 gttatcatat catgcttcaa ctattaaatt aagcccatca tatcatagca ctaaaaagat 1020 tgagttaaaa ataagattta aaaaatatat attgattaaa atgtaccact agaaaggtat 1080 tacatgtgta taagtatggg taaaaaggca agtcactagt ttgagatgaa aactaaaatt 1140 ttcatggtaa aatgccagca tgtatgtact tgtgtagtgt gtacttctaa acagagaagg 1200 cttataaaag taaatgcatt aaggccaagt gcagtggctc acaccggtaa tcccagcact 1260 ttgggaggcc gaggtgggag gattgcttga gctcatgagt tcaagaccag cctgggcaac 1320 atagcgagac tccatctcta taaataaaaa aaaaggaaat gcattaaata gaaggttgat 1380 agtttatcat aaacctgcgg ggaagaaact cagactttct atttttgata ttttgtgcat 1440 taatacatta caaacatgaa gatgtttgta aagttttgtt ttagtcattt tctttgcagt 1500 cacatcattg taccaccttc attattgtat agagctgctt caattctgag tcctctggac 1560 ttcccctgcc tatctgtttg ttgttgttgt tgaagacagt aaaataagtg ttttcaaatc 1620 tatatgtctc ctttttgttg gataatgttt cttcttttta atggtaaata ttcttgttct 1680 tcaacatttt tctttggttc ttttttcctt ttttaggaaa aacaaaacaa cagacttcat 1740 ccttaggttt tctcaagatt taagtgaaca catttacaca tatcaatttc ttaaagaaca 1800 caaaatgttt cctccctagc aaaactattt aagagccaat taaactatga aatagttata 1860 aaattatttt taatatttaa ggccttgaaa ttatattcca aggcaaatct aaatgggtgt 1920 agttgtatat gcacgatgta atttaatgct aaagagtact tacagcttga gggaaaagca 1980 taaagtttta gttaaatagc cttcatactg tggatttttc ctcctactaa ctaatatgtg 2040 ggaaattaag attacagatg ctttgggccc cctcaaacag tacattgcta cagttcactg 2100 tagcaacaga tttggtggtg atggggggat agaggtagaa gcagatagaa ggtaatttta 2160 aagttaattt attatgaatc attttcccct aatctgcata aatgaattag aactgatttt 2220 aataaaaata ttctgtgtaa aaagtactca gaaaaacatc taaagctgtt ggagaagagg 2280 gactcatata aatagttgga ttgcgttttg ctttttattt ctttataaaa atatgtcaaa 2340 aacagttttt aattttagaa atcttatact tgaaagaaac ctcaattatc agtggcttta 2400 tgaagtaaag ttaaaaacaa acataggaaa tgtgaaaata tttgtgtttg ttttgtctga 2460 ctaacttgct gctaaatgct atctttaggt gtgtgaaagt tctttgatat gttattgtcc 2520 ttttacatct tgttaaatag ccattgcttt tgagaatcag atagtgtgtt gtttaggggt 2580 taattgtgtc tatatctttc aaaaactttt atattatgta ttataagaag ttacagtagt 2640 accattttga ttagtctgaa tgttttcagg ccttgaaata aattttgact aagtgatatt 2700 ttttcttaaa aaaaaaaa 2718 <210> 13 <211> 2385 <212> DNA <213> Homo sapiens <400> 13 atggagtcgg ccgacttcta cgaggcggag ccgcggcccc cgatgagcag ccacctgcag 60 agccccccgc acgcgcccag cagcgccgcc ttcggctttc cccggggcgc gggccccgcg 120 cagcctcccg ccccacctgc cgccccggag ccgctgggcg gcatctgcga gcacgagacg 180 tccatcgaca tcagcgccta catcgacccg gccgccttca acgacgagtt cctggccgac 240 ctgttccagc acagccggca gcaggagaag gccaaggcgg ccgtgggccc cacgggcggc 300 ggcggcggcg gcgactttga ctacccgggc gcgcccgcgg gccccggcgg cgccgtcatg 360 cccgggggag cgcacgggcc cccgcccggc tacggctgcg cggccgccgg ctacctggac 420 ggcaggctgg agcccctgta cgagcgcgtc ggggcgccgg cgctgcggcc gctggtgatc 480 aagcaggagc cccgcgagga ggatgaagcc aagcagctgg cgctggccgg cctcttccct 540 taccagccgc cgccgccgcc gccgccctcg cacccgcacc cgcacccgcc gcccgcgcac 600 ctggccgccc cgcacctgca gttccagatc gcgcactgcg gccagaccac catgcacctg 660 cagcccggtc accccacgcc gccgcccacg cccgtgccca gcccgcaccc cgcgcccgcg 720 ctcggtgccg ccggcctgcc gggccctggc agcgcgctca aggggctggg cgccgcgcac 780 cccgacctcc gcgcgagtgg cggcagcggc gcgggcaagg ccaagaagtc ggtggacaag 840 aacagcaacg agtaccgggt gcggcgcgag cgcaacaaca tcgcggtgcg caagagccgc 900 gacaaggcca agcagcgcaa cgtggagacg cagcagaagg tgctggagct gaccagtgac 960 aatgaccgcc tgcgcaagcg ggtggaacag ctgagccgcg aactggacac gctgcggggc 1020 atcttccgcc agctgccaga gagctccttg gtcaaggcca tgggcaactg cgcgtgaggc 1080 gcgcggctgt gggaccgccc tgggccagcc tccggcgggg acccagggag tggtttgggg 1140 tcgccggatc tcgaggcttg cccgagccgt gcgagccagg actaggagat tccggtgcct 1200 cctgaaagcc tggcctgctc cgcgtgtccc ctcccttcct ctgcgccgga cttggtgcgt 1260 ctaagatgag ggggccaggc ggtggcttct ccctgcgagg aggggagaat tcttggggct 1320 gagctgggag cccggcaact ctagtattta ggataacctt gtgccttgga aatgcaaact 1380 caccgctcca atgcctactg agtaggggga gcaaatcgtg ccttgtcatt ttatttggag 1440 gtttcctgcc tccttcccga ggctacagca gacccccatg agagaaggag gggagcaggc 1500 ccgtggcagg aggagggctc agggagctga gatcccgaca agcccgccag ccccagccgc 1560 tcctccacgc ctgtccttag aaaggggtgg aaacataggg acttggggct tggaacctaa 1620 ggttgttccc ctagttctac atgaaggtgg agggtctcta gttccacgcc tctcccacct 1680 ccctccgcac acaccccacc ccagcctgct ataggctggg cttccccttg gggcggaact 1740 cactgcgatg ggggtcacca ggtgaccagt gggagccccc accccgagtc acaccagaaa 1800 gctaggtcgt gggtcagctc tgaggatgta tacccctggt gggagaggga gacctagaga 1860 tctggctgtg gggcgggcat ggggggtgaa gggccactgg gaccctcagc cttgtttgta 1920 ctgtatgcct tcagcattgc ctaggaacac gaagcacgat cagtccatcc cagagggacc 1980 ggagttatga caagctttcc aaatattttg ctttatcagc cgatatcaac acttgtatct 2040 ggcctctgtg ccccagcagt gccttgtgca atgtgaatgt gcgcgtctct gctaaaccac 2100 cattttattt ggtttttgtt ttgttttggt tttgctcgga tacttgccaa aatgagactc 2160 tccgtcggca gctgggggaa gggtctgaga ctccctttcc ttttggtttt gggattactt 2220 ttgatcctgg gggaccaatg aggtgagggg ggttctcctt tgccctcagc tttccccagc 2280 ccctccggcc tgggctgccc acaaggcttg tcccccagag gccctggctc ctggtcggga 2340 agggaggtgg cctcccgcca acgcatcact ggggctggga gcagg 2385 <210> 14 <211> 1908 <212> DNA <213> Homo sapiens <400> 14 gggacgtcag cggacggggc gctcgcgggc cggggctgta tggggctccc gcgcgggtcg 60 ttcttctggg tgctgctcct gctcacggct gcctgctcgg ggctcctctt tgccctgtac 120 ttctcggcgg tgcagcggta cccggggcca gcggccggag ccagggacac cacatcattt 180 gaagcattct ttcaatccaa ggcatcgaat tcttggacag gaaagggcca ggcctgccga 240 cacctgcttc acctggccat tcagcggcac ccccacttcc gtggcctgtt caatctctcc 300 attccagtgc tgctgtgggg ggacctcttc accccagcgc tctgggaccg cctgagccaa 360 cacaaagccc cgtatggctg gcgggggctc tctcaccaag tcatcgcctc caccctgagc 420 cttctgaacg gctcagagag tgccaagctg tttgccccgc ccagggacac ccctccaaag 480 tgtatccggt gtgccgtggt gggcaacgga ggcattctga atgggtcccg ccagggtccc 540 aacatcgatg cccatgacta tgtattcaga ctcaatggag ctgtgatcaa aggcttcgag 600 cgcgatgtgg gcaccaagac ttccttctat ggtttcactg tgaacacgat gaagaactcc 660 ctcgtctcct actggaatct gggcttcacc tccgtgccac aaggacagga cctgcagtat 720 atcttcatcc cctcagacat ccgcgactat gtgatgctga gatcggccat tctgggcgtg 780 cctgtccctg agggcctaga taaaggggac aggccgcacg cctattttgg accagaagcc 840 tctgccagta aattcaagct gctacatccg gacttcatca gctacctgac agaaaggttc 900 ttgaaatcaa agttgattaa cacacatttt ggagacctat atatgcctag taccggggct 960 ctcatgctgc tgacagcttt gcatacctgt gaccaggtca gtgcctatgg attcatcaca 1020 agcaactact ggaaattttc cgaccactat ttcgaacgaa aaatgaagcc attgatattt 1080 tatgcaaacc acgatctgtc cctggaagct gccctgtgga gggacctgca caaggccggc 1140 atccttcagc tgtaccagcg ctgaccccaa tgcactgagc gctttgcttc ttcaagagtt 1200 gcggccctga tcctctcaag tggccaaaag cttttttaac ttttcaatct tcaccttccc 1260 ttgccaacag agggcactgg ggtgaattca agattttcat cgaggtctgt tcaatatagg 1320 acaccccagc ttgtccttgg ctcatccaag aactcttctg tatctaaaac aatacatctc 1380 aatcttggcc aagggaaaat ggactgcttt gctggattgg cactgagcaa ctttaggaaa 1440 tgtcggtgga gtgttcagca agatcagaca gcagtccagg tcaaaggcaa acacacacgc 1500 tccagcccaa atcctcctgg tggcacatcc taccccagat gctaaagtga ttcaaggact 1560 ccaggacacc tcttaagagc ctttctaaga acatgatagg cttacttctg ctccataata 1620 aagtgggaga aaaaagccag aatataactt aagactagat aactgcgtac atgatggacc 1680 attttttttt tttttggctg ggtagagaaa tcatataaaa cgcaggctgt ttagcatgga 1740 gatgactctc agaacactgg gagggtctgg cacttgatgg gggttagttg cttggcagcc 1800 tgcctgccac tgagggaagt cccattagag atgtatcacc accttgtcac caacaggatg 1860 atgtcaccaa caggatgatg tcaccaggta ataaaccttc atcctcac 1908 <210> 15 <211> 2358 <212> DNA <213> Homo sapiens <400> 15 aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca 60 gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc 120 ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc 180 cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg 240 ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc 300 cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg 360 acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg 420 acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga 480 tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca 540 gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg 600 gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga 660 ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc 720 aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc 780 caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga 840 cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga 900 agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga 960 agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg 1020 gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat 1080 gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg 1140 tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag 1200 acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc 1260 agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt 1320 ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa 1380 gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac 1440 actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat 1500 gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat 1560 cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat 1620 tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag 1680 ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat 1740 tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt 1800 ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg 1860 tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg 1920 tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct 1980 gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta 2040 tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga 2100 ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa 2160 tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc 2220 tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt 2280 gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta 2340 taaaaaaaaa aaaaaaaa 2358 <210> 16 <211> 2276 <212> DNA <213> Homo sapiens <400> 16 ctcattgaac tcgcctgcag ctcttgggtt ttttgtggct tccttcgtta ttggagccag 60 gcctacaccc cagcaaccat gtccaaggga cctgcagttg gtattgatct tggcaccacc 120 tactcttgtg tgggtgtttt ccagcacgga aaagtcgaga taattgccaa tgatcaggga 180 aaccgaacca ctccaagcta tgtcgccttt acggacactg aacggttgat cggtgatgcc 240 gcaaagaatc aagttgcaat gaaccccacc aacacagttt ttgatgccaa acgtctgatt 300 ggacgcagat ttgatgatgc tgttgtccag tctgatatga aacattggcc ctttatggtg 360 gtgaatgatg ctggcaggcc caaggtccaa gtagaataca agggagagac caaaagcttc 420 tatccagagg aggtgtcttc tatggttctg acaaagatga aggaaattgc agaagcctac 480 cttgggaaga ctgttaccaa tgctgtggtc acagtgccag cttactttaa tgactctcag 540 cgtcaggcta ccaaagatgc tggaactatt gctggtctca atgtacttag aattattaat 600 gagccaactg ctgctgctat tgcttacggc ttagacaaaa aggttggagc agaaagaaac 660 gtgctcatct ttgacctggg aggtggcact tttgatgtgt caatcctcac tattgaggat 720 ggaatctttg aggtcaagtc tacagctgga gacacccact tgggtggaga agattttgac 780 aaccgaatgg tcaaccattt tattgctgag tttaagcgca agcataagaa ggacatcagt 840 gagaacaaga gagctgtaag acgcctccgt actgcttgtg aacgtgctaa gcgtaccctc 900 tcttccagca cccaggccag tattgagatc gattctctct atgaaggaat cgacttctat 960 acctccatta cccgtgcccg atttgaagaa ctgaatgctg acctgttccg tggcaccctg 1020 gacccagtag agaaagccct tcgagatgcc aaactagaca agtcacagat tcatgatatt 1080 gtcctggttg gtggttctac tcgtatcccc aagattcaga agcttctcca agacttcttc 1140 aatggaaaag aactgaataa gagcatcaac cctgatgaag ctgttgctta tggtgcagct 1200 gtccaggcag ccatcttgtc tggagacaag tctgagaatg ttcaagattt gctgctcttg 1260 gatgtcactc ctctttccct tggtattgaa actgctggtg gagtcatgac tgtcctcatc 1320 aagcgtaata ccaccattcc taccaagcag acacagacct tcactaccta ttctgacaac 1380 cagcctggtg tgcttattca ggtttatgaa ggcgagcgtg ccatgacaaa ggataacaac 1440 ctgcttggca agtttgaact cacaggcata cctcctgcac cccgaggtgt tcctcagatt 1500 gaagtcactt ttgacattga tgccaatggt atactcaatg tctctgctgt ggacaagagt 1560 acgggaaaag agaacaagat tactatcact aatgacaagg gccgtttgag caaggaagac 1620 attgaacgta tggtccagga agctgagaag tacaaagctg aagatgagaa gcagagggac 1680 aaggtgtcat ccaagaattc acttgagtcc tatgccttca acatgaaagc aactgttgaa 1740 gatgagaaac ttcaaggcaa gattaacgat gaggacaaac agaagattct ggacaagtgt 1800 aatgaaatta tcaactggct tgataagaat cagactgctg agaaggaaga atttgaacat 1860 caacagaaag agctggagaa agtttgcaac cccatcatca ccaagctgta ccagagtgca 1920 ggaggcatgc caggaggaat gcctggggga tttcctggtg gtggagctcc tccctctggt 1980 ggtgcttcct cagggcccac cattgaagag gttgattaag ccaaccaagt gtagatgtag 2040 cattgttcca cacatttaaa acatttgaag gacctaaatt cgtagcaaat tctgtggcag 2100 ttttaaaaag ttaagctgct atagtaagtt actgggcatt ctcaatactt gaatatggaa 2160 catatgcaca ggggaaggaa ataacattgc actttataaa cactgtattg taagtggaaa 2220 atgcaatgtc ttaaataaaa ctatttaaaa ttggcaccat aaaaaaaaaa aaaaaa 2276 <210> 17 <211> 1817 <212> DNA <213> Homo sapiens <400> 17 ctcattgaac tcgcctgcag ctcttgggtt ttttgtggct tccttcgtta ttggagccag 60 gcctacaccc cagcaaccat gtccaaggga cctgcagttg gtattgatct tggcaccacc 120 tactcttgtg tgggtgtttt ccagcacgga aaagtcgaga taattgccaa tgatcaggga 180 aaccgaacca ctccaagcta tgtcgccttt acggacactg aacggttgat cggtgatgcc 240 gcaaagaatc aagttgcaat gaaccccacc aacacagttt ttgatgccaa acgtctgatt 300 ggacgcagat ttgatgatgc tgttgtccag tctgatatga aacattggcc ctttatggtg 360 gtgaatgatg ctggcaggcc caaggtccaa gtagaataca agggagagac caaaagcttc 420 tatccagagg aggtgtcttc tatggttctg acaaagatga aggaaattgc agaagcctac 480 cttgggaaga ctgttaccaa tgctgtggtc acagtgccag cttactttaa tgactctcag 540 cgtcaggcta ccaaagatgc tggaactatt gctggtctca atgtacttag aattattaat 600 gagccaactg ctgctgctat tgcttacggc ttagacaaaa aggttggagc agaaagaaac 660 gtgctcatct ttgacctggg aggtggcact tttgatgtgt caatcctcac tattgaggat 720 ggaatctttg aggtcaagtc tacagctgga gacacccact tgggtggaga agattttgac 780 aaccgaatgg tcaaccattt tattgctgag tttaagcgca agcataagaa ggacatcagt 840 gagaacaaga gagctgtaag acgcctccgt actgcttgtg aacgtgctaa gcgtaccctc 900 tcttccagca cccaggccag tattgagatc gattctctct atgaaggaat cgacttctat 960 acctccatta cccgtgcccg atttgaagaa ctgaatgctg acctgttccg tggcaccctg 1020 gacccagtag agaaagccct tcgagatgcc aaactagaca agtcacagat tcatgatatt 1080 gtcctggttg gtggttctac tcgtatcccc aagattcaga agcttctcca agacttcttc 1140 aatggaaaag aactgaataa gagcatcaac cctgatgaag ctgttgctta tggtgcagct 1200 gtccaggcag ccatcttgtc tggagacaag tctgagaatg ttcaagattt gctgctcttg 1260 gatgtcactc ctctttccct tggtattgaa actgctggtg gagtcatgac tgtcctcatc 1320 aagcgtaata ccaccattcc taccaagcag acacagacct tcactaccta ttctgacaac 1380 cagcctggtg tgcttattca ggtttatgaa ggcgagcgtg ccatgacaaa ggataacaac 1440 ctgcttggca agtttgaact cacaggcatg ccaggaggaa tgcctggggg atttcctggt 1500 ggtggagctc ctccctctgg tggtgcttcc tcagggccca ccattgaaga ggttgattaa 1560 gccaaccaag tgtagatgta gcattgttcc acacatttaa aacatttgaa ggacctaaat 1620 tcgtagcaaa ttctgtggca gttttaaaaa gttaagctgc tatagtaagt tactgggcat 1680 tctcaatact tgaatatgga acatatgcac aggggaagga aataacattg cactttataa 1740 acactgtatt gtaagtggaa aatgcaatgt cttaaataaa actatttaaa attggcacca 1800 taaaaaaaaa aaaaaaa 1817 <210> 18 <211> 6609 <212> DNA <213> Homo sapiens <400> 18 ttcttttaag gagtttgccg cgagcgcgtc tccttcattc gcaggctggg cgcgttcgca 60 gtcggctggc ggcgaaggaa ggcgctctcg ggacctcgcg ggcgcgcgtc ttttggctct 120 tgcccctgtc cctgcggctt ggggaaggcg taacccggcg gctaggcgcg ggagaagtgc 180 ggaggagcca tgggcgccgg gagctccacc gagcagcgca gcccggagca gccgcccgag 240 gggagctcca cgccggctga gcccgagccc agcggcggcg gcccctcggc cgaggcggcg 300 ccagacacca ccgcggaccc cgccatcgct gcctcggacc ccgccaccaa gctcctacag 360 aagaatggtc agctgtccac catcaatggc gtagctgagc aagatgagct cagcctccag 420 gagggtgacc taaatggcca gaaaggagcc ctgaacggtc aaggagccct aaacagccag 480 gaggaagaag aagtcattgt cacagaggtt ggacagagag actctgaaga tgtgagcaaa 540 agagactccg ataaagagat ggctactaag tcagcggttg ttcacgacat cacagatgat 600 gggcaggagg agacacccga aataatcgaa cagattcctt cttcagaaag caatttagaa 660 gagctaacac aacccactga gtcccaggct aatgatattg gatttaagaa ggtgtttaag 720 tttgttggct ttaaattcac tgtgaaaaag gataagacag agaagcctga cactgtccag 780 ctactcactg tgaagaaaga tgaaggggag ggagcagcag gggctggcga ccacaaggac 840 cccagccttg gggctggaga agcagcatcc aaagaaagcg aacccaaaca atctacagag 900 aaacccgaag agaccctgaa gcgtgagcaa agccacgcag aaatttctcc cccagccgaa 960 tctggccaag cagtggagga atgcaaagag gaaggagaag agaaacaaga aaaagaacct 1020 agcaagtctg cagaatctcc gactagtccc gtgaccagtg aaacaggatc aaccttcaaa 1080 aaattcttca ctcaaggttg ggccggctgg cgcaaaaaga ccagtttcag gaagccgaag 1140 gaggatgaag tggaagcttc agagaagaaa aaggaacaag agccagaaaa agtagacaca 1200 gaagaagacg gaaaggcaga ggttgcctcc gagaaactga ccgcctccga gcaagcccac 1260 ccacaggagc cggcagaaag tgcccacgag ccccggttat cagctgaata tgagaaagtt 1320 gagctgccct cagaggagca agtcagtggc tcgcagggac cttctgaaga gaaacctgct 1380 ccgttggcga cagaagtgtt tgatgagaaa atagaagtcc accaagaaga ggttgtggcc 1440 gaagtccacg tcagcaccgt ggaggagaga accgaagagc agaaaacgga ggtggaagaa 1500 acagcagggt ctgtgccagc tgaagaattg gttgaaatgg atgcagaacc tcaggaagct 1560 gaacctgcca aggagctggt gaagctcaaa gaaacgtgtg tttccggaga ggaccctaca 1620 cagggagctg acctcagtcc tgatgagaag gtgctgtcca aaccccccga aggcgttgtg 1680 agtgaggtgg aaatgctgtc atcacaggag agaatgaagg tgcagggaag tccactaaag 1740 aagcttttta ccagcactgg cttaaaaaag ctttctggaa agaaacagaa agggaaaaga 1800 ggaggaggag acgaggaatc aggggagcac actcaggttc cagccgattc tccggacagc 1860 caggaggagc aaaagggcga gagctctgcc tcatcccctg aggagcccga ggagatcacg 1920 tgtctggaaa agggcttagc cgaggtgcag caggatgggg aagctgaaga aggagctact 1980 tccgatggag agaaaaaaag agaaggtgtc actccctggg catcattcaa aaagatggtg 2040 acgcccaaga agcgtgttag acggccttcg gaaagtgata aagaagatga gctggacaag 2100 gtcaagagcg ctaccttgtc ttccaccgag agcacagcct ctgaaatgca agaagaaatg 2160 aaagggagcg tggaagagcc aaagccggaa gaaccaaagc gcaaggtgga tacctcagta 2220 tcttgggaag ctttaatttg tgtgggatca tccaagaaaa gagcaaggag agggtcctct 2280 tctgatgagg aagggggacc aaaagcaatg ggaggagacc accagaaagc tgatgaggcc 2340 ggaaaagaca aagagacggg gacagacggg atccttgctg gttcccaaga acatgatcca 2400 gggcagggaa gttcctcccc ggagcaagct ggaagcccta ccgaagggga gggcgtttcc 2460 acctgggagt catttaaaag gttagtcacg ccaagaaaaa aatcaaagtc caagctggaa 2520 gagaaaagcg aagactccat agctgggtct ggtgtagaac attccactcc agacactgaa 2580 cccggtaaag aagaatcctg ggtctcaatc aagaagttta ttcctggacg aaggaagaaa 2640 aggccagatg ggaaacaaga acaagcccct gttgaagacg cagggccaac aggggccaac 2700 gaagatgact ctgatgtccc ggccgtggtc cctctgtctg agtatgatgc tgtagaaagg 2760 gagaaaatgg aggcacagca agcccaaaaa agcgcagagc agcccgagca gaaggcagcc 2820 actgaggtgt ccaaggagct cagcgagagt caggttcata tgatggcagc agctgtcgct 2880 gacgggacga gggcagctac cattattgaa gaaaggtctc cttcttggat atctgcttca 2940 gtgacagaac ctcttgaaca agtagaagct gaagccgcac tgttaactga ggaggtattg 3000 gaaagagaag taattgcaga agaagaaccc cccacggtta ctgaacctct gccagagaac 3060 agagaggccc ggggcgacac ggtcgttagt gaggcggaat tgacccccga agctgtgaca 3120 gctgcagaaa ctgcagggcc attgggtgcc gaagaaggaa ccgaagcatc tgctgctgaa 3180 gagaccacag aaatggtgtc agcagtctcc cagttaaccg actccccaga caccacagag 3240 gaggccactc cggtgcagga ggtggaaggt ggcgtacctg acatagaaga gcaagagagg 3300 cggactcaag aggtcctcca ggcagtggca gaaaaagtga aagaggaatc ccagctgcct 3360 ggcaccggtg ggccagaaga tgtgcttcag cctgtgcaga gagcagaggc agaaagacca 3420 gaagagcagg ctgaagcgtc gggtctgaag aaagagacgg atgtagtgtt gaaagtagat 3480 gctcaggagg caaaaactga gccttttaca caagggaagg tggtggggca gaccacccca 3540 gaaagctttg aaaaagctcc tcaagtcaca gagagcatag agtccagtga gcttgtaacc 3600 acttgtcaag ccgaaacctt agctggggta aaatcacagg agatggtgat ggaacaggct 3660 atcccccctg actcggtgga aacccctaca gacagtgaga ctgatggaag cacccccgta 3720 gccgactttg acgcaccagg cacaacccag aaagacgaga ttgtggaaat ccatgaggag 3780 aatgaggtcg catctggtac ccagtcaggg ggcacagaag cagaggcagt tcctgcacag 3840 aaagagaggc ctccagcacc ttccagtttt gtgttccagg aagaaactaa agaacaatca 3900 aagatggaag acactctaga gcatacagat aaagaggtgt cagtggaaac tgtatccatt 3960 ctgtcaaaga ctgaggggac tcaagaggct gaccagtatg ctgatgagaa aaccaaagac 4020 gtaccatttt tcgaaggact tgaggggtct atagacacag gcataacagt cagtcgggaa 4080 aaggtcactg aagttgccct taaaggtgaa gggacagaag aagctgaatg taaaaaggat 4140 gatgctcttg aactgcagag tcacgctaag tctcctccat cccccgtgga gagagagatg 4200 gtagttcaag tcgaaaggga gaaaacagaa gcagagccaa cccatgtgaa tgaagagaag 4260 cttgagcacg aaacagctgt taccgtatct gaagaggtca gtaagcagct cctccagaca 4320 gtgaatgtgc ccatcataga tggggcaaag gaagtcagca gtttggaagg aagccctcct 4380 ccctgcctag gtcaagagga ggcagtatgc accaaaattc aagttcagag ctctgaggca 4440 tcattcactc taacagcggc tgcagaggag gaaaaggtct taggagaaac tgccaacatt 4500 ttagaaacag gtgaaacgtt ggagcctgca ggtgcacatt tagttctgga agagaaatcc 4560 tctgaaaaaa atgaagactt tgccgctcat ccaggggaag atgctgtgcc cacagggccc 4620 gactgtcagg caaaatcgac accagtgata gtatctgcta ctaccaagaa aggcttaagt 4680 tccgacctgg aaggagagaa aaccacatca ctgaagtgga agtcagatga agtcgatgag 4740 caggttgctt gccaggaggt caaagtgagt gtagcaattg aggatttaga gcctgaaaat 4800 gggattttgg aacttgagac caaaagcagt aaacttgtcc aaaacatcat ccagacagcc 4860 gttgaccagt ttgtacgtac agaagaaaca gccaccgaaa tgttgacgtc tgagttacag 4920 acacaagctc acgtgataaa agctgacagc caggacgctg gacaggaaac ggagaaagaa 4980 ggagaggaac ctcaggcctc tgcacaggat gaaacaccaa ttacttcagc caaagaggag 5040 tcagagtcaa ccgcagtggg acaagcacat tctgatattt ccaaagacat gagtgaagcc 5100 tcagaaaaga ccatgactgt tgaggtagaa ggttccactg taaatgatca gcagctggaa 5160 gaggtcgtcc tcccatctga ggaagaggga ggtggagctg gaacaaagtc tgtgccagaa 5220 gatgatggtc atgccttgtt agcagaaaga atagagaagt cactagttga accgaaagaa 5280 gatgaaaaag gtgatgatgt tgatgaccct gaaaaccaga actcagccct ggctgatact 5340 gatgcctcag gaggcttaac caaagagtcc ccagatacaa atggaccaaa acaaaaagag 5400 aaggaggatg cccaggaagt agaattgcag gaaggaaaag tgcacagtga atcagataaa 5460 gcgatcacac cccaagcaca ggaggagtta cagaaacaag agagagaatc tgcaaagtca 5520 gaacttacag aatcttaaaa catcatgcag ttaaactcat tgtctgtttg gaagaccaga 5580 atgtgaagac aagtagtaga agaaaatgaa tgctgctgct gagactgaag accagtattt 5640 cagaactttg agaattggag agcaggcaca tcaactgatc tcatttctag agagcccctg 5700 acaatcctga ggcttcatca ggagctagag ccatttaaca tttcctcttt ccaagaccaa 5760 cctacaattt tcccttgata accatataaa ttctgattta aggtcctaaa ttcttaacct 5820 ggaactggag ttggcaatac ctagttctgc ttctgaaact ggagtatcat tctttacata 5880 tttatatgta tgttttaagt agtcctcctg tatctattgt atattttttt cttaatgttt 5940 aaggaaatgt gcaggatact acatgctttt tgtatcacac agtatatgat ggggcatgtg 6000 ccatagtgca ggcttgggga gctttaagcc tcagttatat aacccacgaa aaacagagcc 6060 tcctagatgt aacattcctg atcaaggtac aattctttaa aattcactaa tgattgaggt 6120 ccatatttag tggtactctg aaattggtca ctttcctatt acacggagtg tgctaaaact 6180 aaaaagcatt ttgaaacata cagaatgttc tattgtcatt gggaaatttt tctttctaac 6240 ccagtggagg ttagaaagaa gttatattct ggtagcaaat taactttaca tcctttttcc 6300 tacttgttat ggttgtttgg accgataagt gtgcttaatc ctgaggcaaa gtagtgaata 6360 tgttttatat gttatgaaga aaagaattgt tgtaagtttt tgattctact cttatatgct 6420 ggactgcatt cacacatggc atgaaataag tcaggttctt tacaaatggt attttgatag 6480 atactggatt gtgtttgtgc catatttgtg ccattctttt aagaacaatg ttgcaacaca 6540 ttcatttgga taagttgtga tttgacgact gatttaaata aaatatttgc ttcacttaaa 6600 aaaaaaaaa 6609 <210> 19 <211> 6287 <212> DNA <213> Homo sapiens <400> 19 ggcagctccg agggcacctc cggttctccc ccatcctccg ggagtgtctg ggcgctcagt 60 ccgctctgat cccgccgaaa ccacctgcgg ttggcaggca ggagactagg cgtctgccgg 120 ggagggcagg gacccgctaa gctgatctcc tgtacagtag tgctacttaa aatatgctgg 180 ggaccatcac catcacagtt ggacagagag actctgaaga tgtgagcaaa agagactccg 240 ataaagagat ggctactaag tcagcggttg ttcacgacat cacagatgat gggcaggagg 300 agacacccga aataatcgaa cagattcctt cttcagaaag caatttagaa gagctaacac 360 aacccactga gtcccaggct aatgatattg gatttaagaa ggtgtttaag tttgttggct 420 ttaaattcac tgtgaaaaag gataagacag agaagcctga cactgtccag ctactcactg 480 tgaagaaaga tgaaggggag ggagcagcag gggctggcga ccacaaggac cccagccttg 540 gggctggaga agcagcatcc aaagaaagcg aacccaaaca atctacagag aaacccgaag 600 agaccctgaa gcgtgagcaa agccacgcag aaatttctcc cccagccgaa tctggccaag 660 cagtggagga atgcaaagag gaaggagaag agaaacaaga aaaagaacct agcaagtctg 720 cagaatctcc gactagtccc gtgaccagtg aaacaggatc aaccttcaaa aaattcttca 780 ctcaaggttg ggccggctgg cgcaaaaaga ccagtttcag gaagccgaag gaggatgaag 840 tggaagcttc agagaagaaa aaggaacaag agccagaaaa agtagacaca gaagaagacg 900 gaaaggcaga ggttgcctcc gagaaactga ccgcctccga gcaagcccac ccacaggagc 960 cggcagaaag tgcccacgag ccccggttat cagctgaata tgagaaagtt gagctgccct 1020 cagaggagca agtcagtggc tcgcagggac cttctgaaga gaaacctgct ccgttggcga 1080 cagaagtgtt tgatgagaaa atagaagtcc accaagaaga ggttgtggcc gaagtccacg 1140 tcagcaccgt ggaggagaga accgaagagc agaaaacgga ggtggaagaa acagcagggt 1200 ctgtgccagc tgaagaattg gttgaaatgg atgcagaacc tcaggaagct gaacctgcca 1260 aggagctggt gaagctcaaa gaaacgtgtg tttccggaga ggaccctaca cagggagctg 1320 acctcagtcc tgatgagaag gtgctgtcca aaccccccga aggcgttgtg agtgaggtgg 1380 aaatgctgtc atcacaggag agaatgaagg tgcagggaag tccactaaag aagcttttta 1440 ccagcactgg cttaaaaaag ctttctggaa agaaacagaa agggaaaaga ggaggaggag 1500 acgaggaatc aggggagcac actcaggttc cagccgattc tccggacagc caggaggagc 1560 aaaagggcga gagctctgcc tcatcccctg aggagcccga ggagatcacg tgtctggaaa 1620 agggcttagc cgaggtgcag caggatgggg aagctgaaga aggagctact tccgatggag 1680 agaaaaaaag agaaggtgtc actccctggg catcattcaa aaagatggtg acgcccaaga 1740 agcgtgttag acggccttcg gaaagtgata aagaagatga gctggacaag gtcaagagcg 1800 ctaccttgtc ttccaccgag agcacagcct ctgaaatgca agaagaaatg aaagggagcg 1860 tggaagagcc aaagccggaa gaaccaaagc gcaaggtgga tacctcagta tcttgggaag 1920 ctttaatttg tgtgggatca tccaagaaaa gagcaaggag agggtcctct tctgatgagg 1980 aagggggacc aaaagcaatg ggaggagacc accagaaagc tgatgaggcc ggaaaagaca 2040 aagagacggg gacagacggg atccttgctg gttcccaaga acatgatcca gggcagggaa 2100 gttcctcccc ggagcaagct ggaagcccta ccgaagggga gggcgtttcc acctgggagt 2160 catttaaaag gttagtcacg ccaagaaaaa aatcaaagtc caagctggaa gagaaaagcg 2220 aagactccat agctgggtct ggtgtagaac attccactcc agacactgaa cccggtaaag 2280 aagaatcctg ggtctcaatc aagaagttta ttcctggacg aaggaagaaa aggccagatg 2340 ggaaacaaga acaagcccct gttgaagacg cagggccaac aggggccaac gaagatgact 2400 ctgatgtccc ggccgtggtc cctctgtctg agtatgatgc tgtagaaagg gagaaaatgg 2460 aggcacagca agcccaaaaa agcgcagagc agcccgagca gaaggcagcc actgaggtgt 2520 ccaaggagct cagcgagagt caggttcata tgatggcagc agctgtcgct gacgggacga 2580 gggcagctac cattattgaa gaaaggtctc cttcttggat atctgcttca gtgacagaac 2640 ctcttgaaca agtagaagct gaagccgcac tgttaactga ggaggtattg gaaagagaag 2700 taattgcaga agaagaaccc cccacggtta ctgaacctct gccagagaac agagaggccc 2760 ggggcgacac ggtcgttagt gaggcggaat tgacccccga agctgtgaca gctgcagaaa 2820 ctgcagggcc attgggtgcc gaagaaggaa ccgaagcatc tgctgctgaa gagaccacag 2880 aaatggtgtc agcagtctcc cagttaaccg actccccaga caccacagag gaggccactc 2940 cggtgcagga ggtggaaggt ggcgtacctg acatagaaga gcaagagagg cggactcaag 3000 aggtcctcca ggcagtggca gaaaaagtga aagaggaatc ccagctgcct ggcaccggtg 3060 ggccagaaga tgtgcttcag cctgtgcaga gagcagaggc agaaagacca gaagagcagg 3120 ctgaagcgtc gggtctgaag aaagagacgg atgtagtgtt gaaagtagat gctcaggagg 3180 caaaaactga gccttttaca caagggaagg tggtggggca gaccacccca gaaagctttg 3240 aaaaagctcc tcaagtcaca gagagcatag agtccagtga gcttgtaacc acttgtcaag 3300 ccgaaacctt agctggggta aaatcacagg agatggtgat ggaacaggct atcccccctg 3360 actcggtgga aacccctaca gacagtgaga ctgatggaag cacccccgta gccgactttg 3420 acgcaccagg cacaacccag aaagacgaga ttgtggaaat ccatgaggag aatgaggtcg 3480 catctggtac ccagtcaggg ggcacagaag cagaggcagt tcctgcacag aaagagaggc 3540 ctccagcacc ttccagtttt gtgttccagg aagaaactaa agaacaatca aagatggaag 3600 acactctaga gcatacagat aaagaggtgt cagtggaaac tgtatccatt ctgtcaaaga 3660 ctgaggggac tcaagaggct gaccagtatg ctgatgagaa aaccaaagac gtaccatttt 3720 tcgaaggact tgaggggtct atagacacag gcataacagt cagtcgggaa aaggtcactg 3780 aagttgccct taaaggtgaa gggacagaag aagctgaatg taaaaaggat gatgctcttg 3840 aactgcagag tcacgctaag tctcctccat cccccgtgga gagagagatg gtagttcaag 3900 tcgaaaggga gaaaacagaa gcagagccaa cccatgtgaa tgaagagaag cttgagcacg 3960 aaacagctgt taccgtatct gaagaggtca gtaagcagct cctccagaca gtgaatgtgc 4020 ccatcataga tggggcaaag gaagtcagca gtttggaagg aagccctcct ccctgcctag 4080 gtcaagagga ggcagtatgc accaaaattc aagttcagag ctctgaggca tcattcactc 4140 taacagcggc tgcagaggag gaaaaggtct taggagaaac tgccaacatt ttagaaacag 4200 gtgaaacgtt ggagcctgca ggtgcacatt tagttctgga agagaaatcc tctgaaaaaa 4260 atgaagactt tgccgctcat ccaggggaag atgctgtgcc cacagggccc gactgtcagg 4320 caaaatcgac accagtgata gtatctgcta ctaccaagaa aggcttaagt tccgacctgg 4380 aaggagagaa aaccacatca ctgaagtgga agtcagatga agtcgatgag caggttgctt 4440 gccaggaggt caaagtgagt gtagcaattg aggatttaga gcctgaaaat gggattttgg 4500 aacttgagac caaaagcagt aaacttgtcc aaaacatcat ccagacagcc gttgaccagt 4560 ttgtacgtac agaagaaaca gccaccgaaa tgttgacgtc tgagttacag acacaagctc 4620 acgtgataaa agctgacagc caggacgctg gacaggaaac ggagaaagaa ggagaggaac 4680 ctcaggcctc tgcacaggat gaaacaccaa ttacttcagc caaagaggag tcagagtcaa 4740 ccgcagtggg acaagcacat tctgatattt ccaaagacat gagtgaagcc tcagaaaaga 4800 ccatgactgt tgaggtagaa ggttccactg taaatgatca gcagctggaa gaggtcgtcc 4860 tcccatctga ggaagaggga ggtggagctg gaacaaagtc tgtgccagaa gatgatggtc 4920 atgccttgtt agcagaaaga atagagaagt cactagttga accgaaagaa gatgaaaaag 4980 gtgatgatgt tgatgaccct gaaaaccaga actcagccct ggctgatact gatgcctcag 5040 gaggcttaac caaagagtcc ccagatacaa atggaccaaa acaaaaagag aaggaggatg 5100 cccaggaagt agaattgcag gaaggaaaag tgcacagtga atcagataaa gcgatcacac 5160 cccaagcaca ggaggagtta cagaaacaag agagagaatc tgcaaagtca gaacttacag 5220 aatcttaaaa catcatgcag ttaaactcat tgtctgtttg gaagaccaga atgtgaagac 5280 aagtagtaga agaaaatgaa tgctgctgct gagactgaag accagtattt cagaactttg 5340 agaattggag agcaggcaca tcaactgatc tcatttctag agagcccctg acaatcctga 5400 ggcttcatca ggagctagag ccatttaaca tttcctcttt ccaagaccaa cctacaattt 5460 tcccttgata accatataaa ttctgattta aggtcctaaa ttcttaacct ggaactggag 5520 ttggcaatac ctagttctgc ttctgaaact ggagtatcat tctttacata tttatatgta 5580 tgttttaagt agtcctcctg tatctattgt atattttttt cttaatgttt aaggaaatgt 5640 gcaggatact acatgctttt tgtatcacac agtatatgat ggggcatgtg ccatagtgca 5700 ggcttgggga gctttaagcc tcagttatat aacccacgaa aaacagagcc tcctagatgt 5760 aacattcctg atcaaggtac aattctttaa aattcactaa tgattgaggt ccatatttag 5820 tggtactctg aaattggtca ctttcctatt acacggagtg tgctaaaact aaaaagcatt 5880 ttgaaacata cagaatgttc tattgtcatt gggaaatttt tctttctaac ccagtggagg 5940 ttagaaagaa gttatattct ggtagcaaat taactttaca tcctttttcc tacttgttat 6000 ggttgtttgg accgataagt gtgcttaatc ctgaggcaaa gtagtgaata tgttttatat 6060 gttatgaaga aaagaattgt tgtaagtttt tgattctact cttatatgct ggactgcatt 6120 cacacatggc atgaaataag tcaggttctt tacaaatggt attttgatag atactggatt 6180 gtgtttgtgc catatttgtg ccattctttt aagaacaatg ttgcaacaca ttcatttgga 6240 taagttgtga tttgacgact gatttaaata aaatatttgc ttcactt 6287 <210> 20 <211> 3239 <212> DNA <213> Homo sapiens <400> 20 gggggtccgt tccccaactt cctcggcgct ccggactccc aagtctccgc cggaccctcc 60 tttggatatt cctcgtgtct ccgattctga gacagagggg gaagacggtg gggcctcccc 120 acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac 180 caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag 240 tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg 300 ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga 360 gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta 420 tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg 480 taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt 540 ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc 600 cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg 660 ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca 720 gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca 780 ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat 840 ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc 900 catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga 960 cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa 1020 gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc 1080 cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt 1140 gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca 1200 cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga 1260 agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag 1320 acttgtcacc aggaaggcga tcttgactct gctgagaacc gtgggggccg aatactgctt 1380 cccacccatc cacggggtcc ccgcggagca gggctctgca gcgccacatc atcccttctc 1440 cctggaaaga gctcagcccc caccgatcag cctaaacaac ctagaactac aggatctcat 1500 gcacatctca cgggcccgga agccagcgtt catcctgggc tccatgaggg acgagaagcg 1560 gacccacgac cacctgctgt gcctggatgg aggaggagtg aaaggcctca tcatcatcca 1620 gctcctcatc gccatcgaga aggcctcggg tgtggccacc aaggacctgt ttgactgggt 1680 ggcgggcacc agcactggag gcatcctggc cctggccatt ctgcacagta agtccatggc 1740 ctacatgcgc ggcatgtact ttcgcatgaa ggatgaggtg ttccggggct ccaggcccta 1800 cgagtcgggg cccctggagg agttcctgaa gcgggagttt ggggagcaca ccaagatgac 1860 ggacgtcagg aaacccaagg tgatgctgac agggacactg tctgaccggc agccggctga 1920 actccacctc ttccggaact acgatgctcc agaaactgtc cgggagcctc gtttcaacca 1980 gaacgttaac ctcaggcctc cagctcagcc ctcagaccag ctggtgtggc gggcggcccg 2040 aagcagcggg gcagctccta cttacttccg acccaatggg cgcttcctgg acggtgggct 2100 gctggccaac aaccccacgc tggatgccat gaccgagatc catgagtaca atcaggacct 2160 gatccgcaag ggtcaggcca acaaggtgaa gaaactctcc atcgttgtct ccctggggac 2220 agggaggtcc ccacaagtgc ctgtgacctg tgtggatgtc ttccgtccca gcaacccctg 2280 ggagctggcc aagactgttt ttggggccaa ggaactgggc aagatggtgg tggactgttg 2340 cacggatcca gacgggcggg ctgtggaccg ggcacgggcc tggtgcgaga tggtcggcat 2400 ccagtacttc agattgaacc cccagctggg gacggacatc atgctggatg aggtcagtga 2460 cacagtgctg gtcaacgccc tctgggagac cgaggtctac atctatgagc accgcgagga 2520 gttccagaag ctcatccagc tgctgctctc accctgaggg tccccagcct ctcaccggcc 2580 ccagctgacc tcgtccattc agcccctgcc aggccaagcc cagccactgc cctcccgggc 2640 agatctgggc ccaggcacct ctgagtccat agaccaggcc tgggagaatg ccaagctgcc 2700 tgcccgaggc tggtcctgaa ggcctgtctc ccactaaccc cgccttccag cactttctgt 2760 cattccaggc tgggaaagtc tagagccccc tttggcccct ttccctgact gtcaaggaca 2820 actgactccc ccatcagctc aaacattaag ggtacccggg cacaaccgta cccctgcccc 2880 cagccccagc ctccctgagg gcctgccggg ctgcctctgc cccagccccc agcaagggca 2940 ctcccaggct tcctggtggg tgcagcccac tccctctgcc ctctgctccg ttccctgggg 3000 gctgggacta aagaaatggg tgtcccccac cccatcagct gggaaagccc aggccgcagg 3060 agtgggatgc ccgttggact ttgcccctca cactggccca gcccctcaca ctgccccacc 3120 ccgagaaccc tcagctctca aaggtcactc ctgggagttt cttcttccca atggaagtgg 3180 cttaagagcc aaaactgaaa taaatcattt ggattcaagt tcaaaaaaaa aaaaaaaaa 3239 <210> 21 <211> 3074 <212> DNA <213> Homo sapiens <400> 21 gggggtccgt tccccaactt cctcggcgct ccggactccc aagtctccgc cggaccctcc 60 tttggatatt cctcgtgtct ccgattctga gacagagggg gaagacggtg gggcctcccc 120 acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac 180 caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag 240 tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg 300 ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga 360 gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta 420 tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg 480 taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt 540 ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc 600 cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg 660 ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca 720 gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca 780 ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat 840 ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc 900 catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga 960 cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa 1020 gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc 1080 cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt 1140 gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca 1200 cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga 1260 agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag 1320 acaactacag gatctcatgc acatctcacg ggcccggaag ccagcgttca tcctgggctc 1380 catgagggac gagaagcgga cccacgacca cctgctgtgc ctggatggag gaggagtgaa 1440 aggcctcatc atcatccagc tcctcatcgc catcgagaag gcctcgggtg tggccaccaa 1500 ggacctgttt gactgggtgg cgggcaccag cactggaggc atcctggccc tggccattct 1560 gcacagtaag tccatggcct acatgcgcgg catgtacttt cgcatgaagg atgaggtgtt 1620 ccggggctcc aggccctacg agtcggggcc cctggaggag ttcctgaagc gggagtttgg 1680 ggagcacacc aagatgacgg acgtcaggaa acccaaggtg atgctgacag ggacactgtc 1740 tgaccggcag ccggctgaac tccacctctt ccggaactac gatgctccag aaactgtccg 1800 ggagcctcgt ttcaaccaga acgttaacct caggcctcca gctcagccct cagaccagct 1860 ggtgtggcgg gcggcccgaa gcagcggggc agctcctact tacttccgac ccaatgggcg 1920 cttcctggac ggtgggctgc tggccaacaa ccccacgctg gatgccatga ccgagatcca 1980 tgagtacaat caggacctga tccgcaaggg tcaggccaac aaggtgaaga aactctccat 2040 cgttgtctcc ctggggacag ggaggtcccc acaagtgcct gtgacctgtg tggatgtctt 2100 ccgtcccagc aacccctggg agctggccaa gactgttttt ggggccaagg aactgggcaa 2160 gatggtggtg gactgttgca cggatccaga cgggcgggct gtggaccggg cacgggcctg 2220 gtgcgagatg gtcggcatcc agtacttcag attgaacccc cagctgggga cggacatcat 2280 gctggatgag gtcagtgaca cagtgctggt caacgccctc tgggagaccg aggtctacat 2340 ctatgagcac cgcgaggagt tccagaagct catccagctg ctgctctcac cctgagggtc 2400 cccagcctct caccggcccc agctgacctc gtccattcag cccctgccag gccaagccca 2460 gccactgccc tcccgggcag atctgggccc aggcacctct gagtccatag accaggcctg 2520 ggagaatgcc aagctgcctg cccgaggctg gtcctgaagg cctgtctccc actaaccccg 2580 ccttccagca ctttctgtca ttccaggctg ggaaagtcta gagccccctt tggccccttt 2640 ccctgactgt caaggacaac tgactccccc atcagctcaa acattaaggg tacccgggca 2700 caaccgtacc cctgccccca gccccagcct ccctgagggc ctgccgggct gcctctgccc 2760 cagcccccag caagggcact cccaggcttc ctggtgggtg cagcccactc cctctgccct 2820 ctgctccgtt ccctgggggc tgggactaaa gaaatgggtg tcccccaccc catcagctgg 2880 gaaagcccag gccgcaggag tgggatgccc gttggacttt gcccctcaca ctggcccagc 2940 ccctcacact gccccacccc gagaaccctc agctctcaaa ggtcactcct gggagtttct 3000 tcttcccaat ggaagtggct taagagccaa aactgaaata aatcatttgg attcaagttc 3060 aaaaaaaaaa aaaa 3074 <210> 22 <211> 1466 <212> DNA <213> Homo sapiens <400> 22 acaccacgaa cgcctgggac gcagctcctc cttccctggg gagccagccc ctctaccgct 60 ccagcctctc ccacctggga ccgcagcacc tgcccccagg atcctccacc tccggtgcag 120 tcagtgcctc cctccccagc ggtccctcaa gcagcccagg gagcgtccct gccactgtgc 180 ccatgcagat gccaaagccc agcagagtcc agcaggcgct cgcaggagcg accccgaagc 240 cagagccaga gccagagcag gtcataaaaa actacacgga agagctgaaa gtgcccccag 300 atgaggactg catcatctgc atggagaagc tgtccgcagc gtctggatac agcgatgtga 360 ctgacagcaa ggcaatcggg cccctggctg tgggctgcct caccaagtgc agccacgcct 420 tccacctgct gtgcctcctg gccatgtact gcaacggcaa taagggccct gagcacccca 480 atcccggaaa gccgttcact gccagagggt ttccccgcca gtgctacctt ccagacaacg 540 cccagggccg caagcctcca ggggcttcca gaacccggag acactggctg acattccggc 600 ctccccacag ctgctgaccg atggccacta catgacgctg cccgtgtctc cggaccagct 660 gccctgtgac gaccccatgg cgggcagcgg tggtgccccc gtgctgcggg tgggccatga 720 ccacggctgc caccagcagc ccttctgcaa cgcgcccctc cctggccctg gaccctatcg 780 tacagaacct gctaaggcca tcaaacctat tgatcggaag tcagtccatc agatttgctc 840 tgggccggtg gtactgagtc taagcactgg atgaagaaga tagtagaaaa cagtctggat 900 gctggtgcca ctaatgttga tctaaagctt aaggactatg gaatggatct cattgaagtt 960 tcaggcaatg gatgtggggt agaagaagaa aacttcgaag gcttaatgat gtcaccattt 1020 ctacctgcca cgtatcggcg aaggttggga ctcgactggt gtttgatcac gatgggaaaa 1080 tcatccagaa aaccccctac ccccacccca gagggaccac agtcagcgtg aagcagttat 1140 tttctacgct acctgtgcgc cataaggaat ttcaaaggaa tattaagaag aaacgtgcct 1200 gcttcccctt cgccttctgc cgtgattgtc agcttcttga gggctcccca gccatgcttc 1260 ctgtacagcc tgcaaaactg actcctagaa gtaccccacc ccacccctgc tccttggagg 1320 acaacgtgat cactgtattc agctccatca agaatggtcc aggttcttct agatgatctg 1380 cacaaatggt tcctctcctc cttcctgatg tctgccatta gcattggaat aaagttcctg 1440 ctgaaaaaaa aaaaaaaaaa aaaaaa 1466 <210> 23 <211> 6116 <212> DNA <213> Homo sapiens <400> 23 ctccgactct cggcacctgg cctccagctt tcggaactat ggaggccgcg cccgggaccc 60 ccccgccgcc gccatcagag tcgccgccgc cgccatcgcc gccgccgcca tcaacgcctt 120 cgcctcctcc gtgttccccc gacgcccgcc cggccacccc gcacctcctc caccaccgcc 180 tcccgctccc tgacgacagg gaagatggag agttggaaga aggtgaattg gaagatgatg 240 gggcagagga gacccaggat acctccggag ggcctgagag aagccggaaa gaaaaggggg 300 agaagcatca cagtgattcg gatgaggaga agtcccacag gagactgaag cggaaacgga 360 agaaagagcg ggagaaagag aaaaggaggt cgaagaagag gaggaaatcc aagcacaaac 420 gccatgcttc ttctagcgat gacttctctg acttctcaga tgactcggat ttcagcccca 480 gtgagaaagg tcaccgcaag tacagagagt acagcccccc atatgcgccg tcccaccagc 540 agtacccccc atcgcatgcc acgcccctgc ccaagaaggc atactccaag atggacagca 600 agagttatgg catgtacgag gactacgaga atgagcagta tggggaatat gagggcgacg 660 aggaggagga catgggcaag gaggactatg acgacttcac caaagagctg aaccagtacc 720 ggcgtgccaa ggagggcagc agccgcggcc gaggcagccg aggccggggc cggggctaca 780 ggggccgagg aagccgtgga ggatcgcgag gccgcggcat gggcaggggc agccgaggca 840 ggggcagagg ctctatggga ggagaccacc cggaggatga agaggatttc tacgaggaag 900 agatggacta tggagagagt gaggagccaa tgggagacga cgactatgac gagtactcca 960 aggagctgaa ccagtaccgc cgctccaagg acagccgagg ccgagggcta agtcgaggcc 1020 gtggcagggg ctcccgaggt cgagggaaag gaatgggtcg gggccgaggc cgaggtggca 1080 gccgaggagg gatgaacaag ggcggaatga acgatgacga agacttctat gacgaggaca 1140 tgggcgacgg tggtggtgga agctaccgga gtcgtgacca tgacaagccc caccagcagt 1200 cggacaagaa aggcaaagtc atttgcaagt acttcgtgga agggcgctgc acctggggag 1260 accactgtaa ttttagccat gacatcgaac tcccaaagaa gcgagaactg tgcaagtttt 1320 acatcactgg attttgcgcc agagctgaga actgccctta tatgcacggt gatttcccgt 1380 gtaagctgta ccacaccact gggaactgca tcaatggtga cgactgcatg ttttcccacg 1440 accctctgac cgaagagacg agggagctct tggataagat gttggccgat gatgcagaag 1500 caggtgccga ggatgagaag gaggtggagg aactgaagaa gcagggcatc aaccccctgc 1560 ccaaaccgcc ccctggtgtg ggcctcctgc ccacccctcc tcggccccct ggcccgcagg 1620 ctccaacctc tcccaacggc aggcccatgc agggtggccc cccgcccccg ccccctcccc 1680 ctcccccacc gcccgggccc cctcagatgc ccatgccggt gcatgagcca ctgtccccgc 1740 agcagctgca gcagcaggac atgtacaaca agaagatccc ctccttgttt gagatcgtgg 1800 tgcggcccac gggacagctg gctgagaagc tgggtgtgag gttccctgga cccggtggac 1860 ccccagggcc aatgggccct gggcccaaca tgggaccccc agggccaatg ggcggtccaa 1920 tgcatcctga catgcacccc gacatgcacc cggacatgca ccctgacatg cacgcagaca 1980 tgcacgcaga catgccgatg ggccctggca tgaatcctgg cccacccatg ggccctggcg 2040 gccctccaat gatgccctac ggccctggag actccccaca ttctggaatg atgcccccta 2100 tcccgccagc ccagaacttc tatgaaaact tctaccagca gcaggagggc atggagatgg 2160 agcccggact cctgggggat gcagaggact acgggcacta cgaagagctg ccaggggagc 2220 ctggggagca cctcttccct gagcaccctc tggagcccga cagcttctct gagggagggc 2280 ccccaggccg gccgaagcca ggcgccggtg tccctgactt cctgccctca gcccagaggg 2340 ccctgtacct gaggatccag cagaagcagc aggaggagga ggagagagcg aggaggctgg 2400 ctgagagcag caagcaggac cgggagaatg aggaaggtga caccggaaac tggtactcaa 2460 gtgatgagga tgagggtgga agcagtgtca cctccatcct gaagaccttg aggcagcaga 2520 cgtccagccg acccccggct tcagttgggg agctgagcag cagtgggctg ggggaccccc 2580 gcctccagaa gggacacccc acaggaagcc ggctggctga ccctcgcctc agccgggacc 2640 ccagactcac ccgccatgtg gaggcttctg gcgggtctgg cccaggtgat tcgggaccct 2700 ccgatcctcg gctggctcgc gccctgccca cctccaagcc cgaaggcagc cttcattcca 2760 gccctgtggg ccccagcagt tccaaggggt ctgggccgcc cccaacggag gaggaggaag 2820 gggagcgggc cctgcgggag aaggccgtga acattcccct ggacccactc cccgggcacc 2880 ctctgcggga cccacggtca cagctgcagc agttcagcca catcaagaag gacgtgaccc 2940 tgagcaagcc cagcttcgcc cgcaccgtgc tctggaatcc cgaggacctg atccccctac 3000 ccatccccaa gcaggacgca gtgccccccg tgcccgcggc cctgcaatcc atgcccaccc 3060 tggacccccg gctgcaccgc gctgccacgg cagggccccc caacgcccgg cagcgcccgg 3120 gcgcctccac ggattccagc acacagggcg ccaacctccc cgactttgaa cttctgtctc 3180 gcatcctcaa gacagtcaat gccaccggct cctcggccgc ccccggttcc agcgacaaac 3240 ccagtgaccc ccgggtgcgg aaggccccca ccgaccctcg gctgcagaaa cccacagact 3300 ctacggcctc ctcccgggct gccaagcccg gccctgctga ggcgccctct cccaccgcca 3360 gcccgagtgg ggatgcctcc ccaccagcca ccgctcccta cgacccccgc gtgctggcgg 3420 ccggtggact gggccagggc ggagggggcg ggcagagcag tgtgctgagc ggtatcagcc 3480 tctacgaccc gaggactccc aacgcggggg gcaaagccac agagccggct gctgacacgg 3540 gtgcccagcc caagggtgct gagggcaatg gcaagagctc ggcctccaag gctaaggagc 3600 ccccgttcgt ccgcaagtct gccctggaac agccagagac agggaaggcc ggtgctgatg 3660 ggggcacccc cacggacaga tacaacagct acaaccggcc ccggcccaag gctgctgcag 3720 cccccgctgc caccaccgcc accccacccc ccgagggtgc cccaccccag cccggggtgc 3780 acaacctgcc cgtgcccacc ctcttcggga cggtgaagca gacacccaag acgggctcag 3840 gaagcccatt tgctgggaac agtccggccc gcgagggtga gcaggatgcg gcatccctga 3900 aggatgtttt taaaggcttc gaccccacgg cctccccctt ttgccagtag tgtccagcca 3960 gagctgcggc tccagccacc cttcctaggg tggcattcag ggcagcaccc agggtaggga 4020 acttgggggc aaggggaggc aggctgggtg ttcctttttt cttttctttt tcttttgctt 4080 tccgtctctt ttattttttt ttaaagtagt actttctttg agatttgtaa attgtatata 4140 accatcttaa gttctggtca gtgtggcggg ctcaggggct cctgctgagc aaaccgactc 4200 atgcccgcaa acctgtgaac tttcgccagt gcctggcctc agactctgtg ggctctgcgt 4260 ggccgggcct tgctggaggc ccagtgggtt ttctgggcaa agcatggccc cttttcccca 4320 ggacaaaggg aacagttggt gtctgggaag gtattgaacg ctcctcaccc tgtgcccgaa 4380 gagacccgga accaagacca tggcagggcc tgcgtggaag caggtccagg cgtttctaga 4440 accctagggt gcaccatcac tgtcttttca gtgcaggctg taacaaccca ctcaggagac 4500 agtgagagtg aaaaggtatt aaggaaaaag cccccagcgg cactatgggg gctccctggc 4560 gcatgcctgc tcctgtccct ggattaccac acgtgccctc cctgccaccc tccgtctaga 4620 gcaagcggat gccccccagc ctgcagcaga agcctccaca gtgagaactg gacccaaagg 4680 tagtgggggc cggtgtgggg cagagtcctg aagagccacc tctaggaggc agcccctagg 4740 agcacgcacg ttctgtcagt attaccccac ctgtcctatc aggtgggcca caccctgctt 4800 gcccacacca gggtctgtcc tggtcctcaa gccacgcacc cgctatgcct gcactgcagc 4860 ccagccccgg acagctccag gatccgtgca gtggctgcgc cgccaggccc caacaatggg 4920 gaccctgggg tggctcctgg ccaagtgttc tctgttttcc tcgcacctcc ttacactgtg 4980 tgacctgcag ggcatgaggt attgatgtgt tcgggtttcc tttcccaagc cagcagatgc 5040 aggtgttcca aggtgtgttg ctctgtggga tttgtggaca cttaagaaac ggactgagtg 5100 ggaaccctgc agccagggga tggggagcct ctgctccccc catgctccca ccctggctga 5160 gggccagcct catctgcaga gccctggagg aggcccacct atggacacag cccgagagat 5220 gggcgcaagg ggtgctgggg gaggcctgct atcctgcctc tgggccactt gaggggcctc 5280 aggaagtgtg tgcttgtggc tgcatctgcc cgtctccctg gcccaccatg tggctgcagg 5340 ccaagctctt cattgctgac catgaagaga cctagttacc tgccaaggga ttccccttcc 5400 ctcctcctca gggtggggtg aacaaggctc ctatcccacc ccaccccaaa aagagaaaaa 5460 tgaaaaactc atagtttgga gccaggaggc agggtgtcct acagggctgc acagccctga 5520 ggggtcagtg ctgggatctg gttggttggt ttgtcttttt gtcttttttt tttttttttt 5580 ttttacacaa tcattaatga gatttgtctt cagccaccag tgttggcctt gaagcagagg 5640 gcacagccct tggtgtttgt aaaataagta tgaatacaca gtgtggcagt gttgtggttt 5700 ttgttgttgt ttttcctctc cttttgagaa ttttcttttg taaaagaaaa atatttttta 5760 aaccgaaatc tgtggatgaa atagaagctg gagccctcct cttggaatat tcagcctaag 5820 aacctcatag gactatgaat tcacccgaaa ttctcatttg ccatcaggcc gagcttttaa 5880 agaaaaattg ttctctaacc aggattgtaa caaaagtgta aatactgttt cagagttgag 5940 agttggtggt gcaaatatgt atataatgaa ctgtattttt acaatgatcg ccgcatgact 6000 atttcacacc ctttttatac tccatatctg tcttccagaa acgtcacctg cctttctcct 6060 gtggtctctt aatccagtaa ttgtattact gccattaaag gatgcagtta ttttaa 6116 <210> 24 <211> 6116 <212> DNA <213> Homo sapiens <400> 24 ctccgactct cggcacctgg cctccagctt tcggaactat ggaggccgcg cccgggaccc 60 ccccgccgcc gccatcagag tcgccgccgc cgccatcgcc gccgccgcca tcaacgcctt 120 cgcctcctcc gtgttccccc gacgcccgcc cggccacccc gcacctcctc caccaccgcc 180 tcccgctccc tgacgacagg gaagatggag agttggaaga aggtgaattg gaagatgatg 240 gggcagagga gacccaggat acctccggag ggcctgagag aagccggaaa gaaaaggggg 300 agaagcatca cagtgattcg gatgaggaga agtcccacag gagactgaag cggaaacgga 360 agaaagagcg ggagaaagag aaaaggaggt cgaagaagag gaggaaatcc aagcacaaac 420 gccatgcttc ttctagcgat gacttctctg acttctcaga tgactcggat ttcagcccca 480 gtgagaaagg tcaccgcaag tacagagagt acagcccccc atatgcgccg tcccaccagc 540 agtacccccc atcgcatgcc acgcccctgc ccaagaaggc atactccaag atggacagca 600 agagttatgg catgtacgag gactacgaga atgagcagta tggggaatat gagggcgacg 660 aggaggagga catgggcaag gaggactatg acgacttcac caaagagctg aaccagtacc 720 ggcgtgccaa ggagggcagc agccgcggcc gaggcagccg aggccggggc cggggctaca 780 ggggccgagg aagccgtgga ggatcgcgag gccgcggcat gggcaggggc agccgaggca 840 ggggcagagg ctctatggga ggagaccacc cggaggatga agaggatttc tacgaggaag 900 agatggacta tggagagagt gaggagccaa tgggagacga cgactatgac gagtactcca 960 aggagctgaa ccagtaccgc cgctccaagg acagccgagg ccgagggcta agtcgaggcc 1020 gtggcagggg ctcccgaggt cgagggaaag gaatgggtcg gggccgaggc cgaggtggca 1080 gccgaggagg gatgaacaag ggcggaatga acgatgacga agacttctat gacgaggaca 1140 tgggcgacgg tggtggtgga agctaccgga gtcgtgacca tgacaagccc caccagcagt 1200 cggacaagaa aggcaaagtc atttgcaagt acttcgtgga agggcgctgc acctggggag 1260 accactgtaa ttttagccat gacatcgaac tcccaaagaa gcgagaactg tgcaagtttt 1320 acatcactgg attttgcgcc agagctgaga actgccctta tatgcacggt gatttcccgt 1380 gtaagctgta ccacaccact gggaactgca tcaatggtga cgactgcatg ttttcccacg 1440 accctctgac cgaagagacg agggagctct tggataagat gttggccgat gatgcagaag 1500 caggtgccga ggatgagaag gaggtggagg aactgaagaa gcagggcatc aaccccctgc 1560 ccaaaccgcc ccctggtgtg ggcctcctgc ccacccctcc tcggccccct ggcccgcagg 1620 ctccaacctc tcccaacggc aggcccatgc agggtggccc cccgcccccg ccccctcccc 1680 ctcccccacc gcccgggccc cctcagatgc ccatgccggt gcatgagcca ctgtccccgc 1740 agcagctgca gcagcaggac atgtacaaca agaagatccc ctccttgttt gagatcgtgg 1800 tgcggcccac gggacagctg gctgagaagc tgggtgtgag gttccctgga cccggtggac 1860 ccccagggcc aatgggccct gggcccaaca tgggaccccc agggccaatg ggcggtccaa 1920 tgcatcctga catgcacccc gacatgcacc cggacatgca ccctgacatg cacgcagaca 1980 tgcacgcaga catgccgatg ggccctggca tgaatcctgg cccacccatg ggccctggcg 2040 gccctccaat gatgccctac ggccctggag actccccaca ttctggaatg atgcccccta 2100 tcccgccagc ccagaacttc tatgaaaact tctaccagca gcaggagggc atggagatgg 2160 agcccggact cctgggggat gcagaggact acgggcacta cgaagagctg ccaggggagc 2220 ctggggagca cctcttccct gagcaccctc tggagcccga cagcttctct gagggagggc 2280 ccccaggccg gccgaagcca ggcgccggtg tccctgactt cctgccctca gcccagaggg 2340 ccctgtacct gaggatccag cagaagcagc aggaggagga ggagagagcg aggaggctgg 2400 ctgagagcag caagcaggac cgggagaatg aggaaggtga caccggaaac tggtactcaa 2460 gtgatgagga tgagggtgga agcagtgtca cctccatcct gaagaccttg aggcagcaga 2520 cgtccagccg acccccggct tcagttgggg agctgagcag cagtgggctg ggggaccccc 2580 gcctccagaa gggacacccc acaggaagcc ggctggctga ccctcgcctc agccgggacc 2640 ccagactcac ccgccatgtg gaggcttctg gcgggtctgg cccaggtgat tcgggaccct 2700 ccgatcctcg gctggctcgc gccctgccca cctccaagcc cgaaggcagc cttcattcca 2760 gccctgtggg ccccagcagt tccaaggggt ctgggccgcc cccaacggag gaggaggaag 2820 gggagcgggc cctgcgggag aaggccgtga acattcccct ggacccactc cccgggcacc 2880 ctctgcggga cccacggtca cagctgcagc agttcagcca catcaagaag gacgtgaccc 2940 tgagcaagcc cagcttcgcc cgcaccgtgc tctggaatcc cgaggacctg atccccctac 3000 ccatccccaa gcaggacgca gtgccccccg tgcccgcggc cctgcaatcc atgcccaccc 3060 tggacccccg gctgcaccgc gctgccacgg cagggccccc caacgcccgg cagcgcccgg 3120 gcgcctccac ggattccagc acacagggcg ccaacctccc cgactttgaa cttctgtctc 3180 gcatcctcaa gacagtcaat gccaccggct cctcggccgc ccccggttcc agcgacaaac 3240 ccagtgaccc ccgggtgcgg aaggccccca ccgaccctcg gctgcagaaa cccacagact 3300 ctacggcctc ctcccgggct gccaagcccg gccctgctga ggcgccctct cccaccgcca 3360 gcccgagtgg ggatgcctcc ccaccagcca ccgctcccta cgacccccgc gtgctggcgg 3420 ccggtggact gggccagggc ggagggggcg ggcagagcag tgtgctgagc ggtatcagcc 3480 tctacgaccc gaggactccc aacgcggggg gcaaagccac agagccggct gctgacacgg 3540 gtgcccagcc caagggtgct gagggcaatg gcaagagctc ggcctccaag gctaaggagc 3600 ccccgttcgt ccgcaagtct gccctggaac agccagagac agggaaggcc ggtgctgatg 3660 ggggcacccc cacggacaga tacaacagct acaaccggcc ccggcccaag gctgctgcag 3720 cccccgctgc caccaccgcc accccacccc ccgagggtgc cccaccccag cccggggtgc 3780 acaacctgcc cgtgcccacc ctcttcggga cggtgaagca gacacccaag acgggctcag 3840 gaagcccatt tgctgggaac agtccggccc gcgagggtga gcaggatgcg gcatccctga 3900 aggatgtttt taaaggcttc gaccccacgg cctccccctt ttgccagtag tgtccagcca 3960 gagctgcggc tccagccacc cttcctaggg tggcattcag ggcagcaccc agggtaggga 4020 acttgggggc aaggggaggc aggctgggtg ttcctttttt cttttctttt tcttttgctt 4080 tccgtctctt ttattttttt ttaaagtagt actttctttg agatttgtaa attgtatata 4140 accatcttaa gttctggtca gtgtggcggg ctcaggggct cctgctgagc aaaccgactc 4200 atgcccgcaa acctgtgaac tttcgccagt gcctggcctc agactctgtg ggctctgcgt 4260 ggccgggcct tgctggaggc ccagtgggtt ttctgggcaa agcatggccc cttttcccca 4320 ggacaaaggg aacagttggt gtctgggaag gtattgaacg ctcctcaccc tgtgcccgaa 4380 gagacccgga accaagacca tggcagggcc tgcgtggaag caggtccagg cgtttctaga 4440 accctagggt gcaccatcac tgtcttttca gtgcaggctg taacaaccca ctcaggagac 4500 agtgagagtg aaaaggtatt aaggaaaaag cccccagcgg cactatgggg gctccctggc 4560 gcatgcctgc tcctgtccct ggattaccac acgtgccctc cctgccaccc tccgtctaga 4620 gcaagcggat gccccccagc ctgcagcaga agcctccaca gtgagaactg gacccaaagg 4680 tagtgggggc cggtgtgggg cagagtcctg aagagccacc tctaggaggc agcccctagg 4740 agcacgcacg ttctgtcagt attaccccac ctgtcctatc aggtgggcca caccctgctt 4800 gcccacacca gggtctgtcc tggtcctcaa gccacgcacc cgctatgcct gcactgcagc 4860 ccagccccgg acagctccag gatccgtgca gtggctgcgc cgccaggccc caacaatggg 4920 gaccctgggg tggctcctgg ccaagtgttc tctgttttcc tcgcacctcc ttacactgtg 4980 tgacctgcag ggcatgaggt attgatgtgt tcgggtttcc tttcccaagc cagcagatgc 5040 aggtgttcca aggtgtgttg ctctgtggga tttgtggaca cttaagaaac ggactgagtg 5100 ggaaccctgc agccagggga tggggagcct ctgctccccc catgctccca ccctggctga 5160 gggccagcct catctgcaga gccctggagg aggcccacct atggacacag cccgagagat 5220 gggcgcaagg ggtgctgggg gaggcctgct atcctgcctc tgggccactt gaggggcctc 5280 aggaagtgtg tgcttgtggc tgcatctgcc cgtctccctg gcccaccatg tggctgcagg 5340 ccaagctctt cattgctgac catgaagaga cctagttacc tgccaaggga ttccccttcc 5400 ctcctcctca gggtggggtg aacaaggctc ctatcccacc ccaccccaaa aagagaaaaa 5460 tgaaaaactc atagtttgga gccaggaggc agggtgtcct acagggctgc acagccctga 5520 ggggtcagtg ctgggatctg gttggttggt ttgtcttttt gtcttttttt tttttttttt 5580 ttttacacaa tcattaatga gatttgtctt cagccaccag tgttggcctt gaagcagagg 5640 gcacagccct tggtgtttgt aaaataagta tgaatacaca gtgtggcagt gttgtggttt 5700 ttgttgttgt ttttcctctc cttttgagaa ttttcttttg taaaagaaaa atatttttta 5760 aaccgaaatc tgtggatgaa atagaagctg gagccctcct cttggaatat tcagcctaag 5820 aacctcatag gactatgaat tcacccgaaa ttctcatttg ccatcaggcc gagcttttaa 5880 agaaaaattg ttctctaacc aggattgtaa caaaagtgta aatactgttt cagagttgag 5940 agttggtggt gcaaatatgt atataatgaa ctgtattttt acaatgatcg ccgcatgact 6000 atttcacacc ctttttatac tccatatctg tcttccagaa acgtcacctg cctttctcct 6060 gtggtctctt aatccagtaa ttgtattact gccattaaag gatgcagtta ttttaa 6116 <210> 25 <211> 4805 <212> DNA <213> Homo sapiens <400> 25 gttaagttgg agccgactca gcggcggccg ccattttgtg cagtcgctgg gaaggaagga 60 gacgcctaaa ccgcggcact gcccggtttg agcgtagcca aacctgccca ccggctttgt 120 agccccgatt ctctgtgttt tgctcccgtc tccgacgaga gaggcggcga cggtggcgtc 180 tgcgacggga gacagcgcgt cggagcgaga gagcgctgcg cctgccgccg ccccaacagc 240 ggaggcgccg ccgccatcgg tcgtcaccag accggagccg caggccctcc cgagcccggc 300 catccgtgcc ccgctcccag atctctatcc ttttgggacc atgcgcggag gaggctttgg 360 ggaccgggac cgggatcgtg accgtggagg atttggagca agaggtggtg gtggccttcc 420 cccgaagaaa tttggtaatc ctggggagcg tttgcgtaaa aaaaagtggg atttgagtga 480 gctccccaag tttgagaaaa atttttatgt ggaacatccg gaagtagcaa ggctgacacc 540 atatgaggtt gatgagctac gccgaaagaa ggagattaca gtgagggggg gagatgtttg 600 tcctaaaccc gtgtttgcct tccatcatgc taacttccca caatatgtaa tggatgtgtt 660 gatggatcag cactttacag aaccaactcc aattcagtgc cagggatttc cgttggctct 720 tagtggccgg gatatggtgg gcattgctca gactggctct gggaagacgt tggcgtatct 780 cctgcctgca attgttcata ttaaccacca gccatacttg gaaaggggag atggcccaat 840 ctgtctagtt ctggctccta ccagagagct tgcccagcaa gtacagcagg tggccgatga 900 ctatggcaaa tgttctagat tgaagagtac ttgtatttat ggaggtgctc ctaaaggtcc 960 ccagattcga gacttggaaa gaggtgttga gatctgcata gccactcctg gacgtctgat 1020 agatttcctg gagtcaggaa agacaaatct tcgccgatgt acttaccttg tattggacga 1080 agctgacaga atgcttgata tggggtttga accccagatc cgtaaaattg ttgaccaaat 1140 caggcctgat aggcagacac tgatgtggag tgcaacctgg ccaaaagaag taagacagct 1200 tgcagaggat ttccttcgtg attacaccca gatcaacgta ggcaatctgg agttgagtgc 1260 caaccacaac atcctccaga tagtggatgt ctgcatggaa agtgaaaaag accacaagtt 1320 gatccaacta atggaagaaa taatggctga aaaggaaaac aaaacaataa tatttgtgga 1380 gacaaagaga cgctgtgatg atctgactcg aaggatgcgc agagatggtt ggccagctat 1440 gtgtatccat ggagacaaga gtcaaccaga aagagattgg gtacttaatg agttccgttc 1500 tggaaaggca cccatcctta ttgctacaga tgtagcctcc cgtgggctag atgtggaaga 1560 tgtcaagttt gtgatcaact atgactatcc aaacagctca gaggattatg tgcaccgtat 1620 tggccgaaca gcccgtagca ccaacaaggg taccgcctat accttcttca ccccagggaa 1680 cctaaaacag gccagagagc ttatcaaagt gctggaagag gccaatcagg ctatcaatcc 1740 aaaactgatg cagcttgtgg accacagagg aggcggcgga ggcgggggtg gtcgttctcg 1800 ttaccggacc acttcttcag ccaacaatcc caatctgatg tatcaggatg agtgtgaccg 1860 aaggcttcga ggagtcaagg atggtggccg gagagactct gcaagctatc gggatcgtag 1920 tgaaaccgat agagctggtt atgctaatgg cagtggctat ggaagtccaa attctgcctt 1980 tggagcacaa gcaggccaat acacctatgg tcaaggcacc tatggggcag ctgcttatgg 2040 caccagtagc tatacagctc aagaatatgg tgctggcact tatggagcta gtagcaccac 2100 ctcaactggg agaagttcac agagctctag ccagcagttt agtgggatag gccggtctgg 2160 gcagcagcca cagccactga tgtcacaaca gtttgcacag cctccgggag ctaccaatat 2220 gataggttac atggggcaga ctgcctacca ataccctcct cctcctcccc ctcctcctcc 2280 ttcacgtaaa tgaaaccact caagtggtag tgactccagc agacttaatt acattttaag 2340 gaacactgtc tttccttttt ttttcctctt cgccttttct ttttttttcc ttttttcttt 2400 tttttttttt aatttttccc cccaaccatc gtgatttgtc ttttcatgca gattagttag 2460 aattcactgc caggtttctt ctgcccacca aaatgatcca gtctggaata acattttgta 2520 aaaaaaaaaa aaatatatat atatatatat agctgactgg aagagattaa tttcttcccc 2580 caacttcttg catgttgaag atatttgagc tatttttcat ctaaaagagt aaggtattag 2640 gcccttttgt gggagcccca tgttttgttt ttctgagttg gtggggaggg agggaggggg 2700 agggctgaat tgttttgcag aggaagatgg catctgtgct ttaaatttct cattactggg 2760 ttagaaaaca aagagggatt gccctgcaca ttttcttttg tgcttttaaa tgtttcttaa 2820 gttggaacag gtttcctcgg gcctgttttg actgattgct ggagtgcatt tgatagttaa 2880 aaattactaa ttggttttat ttcccttcac actctgcctc cccacttctc cccccgttac 2940 tgaaaaataa ccattttagt gtcaggctag aaattgaatt gctgagtttt gtgtatcctt 3000 taaattaaaa accacaagtg tttattgtag tggttaaact gtagcatctc agcatctggg 3060 tggaagctgc ctatatttct tcccagttta actggggacc atctgtgaaa ttaattttcc 3120 atccagacag ctgctgtgag caaatgaaca taaatgctcg ctggaaattt actaaccagt 3180 ttttatattg acctgcagtg taaaaagcac atttaattat aaacaatata ttcaaaatgg 3240 gcaaatttta ttttcaaatg cagtgtagag ctagattaaa agcaactctt tgccacctac 3300 tctgcccttt tggcaaagtt accttgaaca aagaatctta agggtttatt aagaactctt 3360 tattttcttc ataccctgtt ctctgcagtg ctttctaaca gcttctgggt gcagattttc 3420 ttcggcatcc ttttgcactc agcttattac aggtaggtag tgcttaagaa aagtcatgga 3480 ggactaaagc ctaagtcctt ttcacttttc ctccatctga aggtaggtga gttcatcctc 3540 ttcatggtaa tgctgtttta ccaagacttt atagcagatg gacccagaaa gaattttctg 3600 ctattgtgtt cactacaaca ggatagggac atcagacagc cccagaaacc ccttccagat 3660 ctgatatggg actattaatt tttatgctgt taattggtat tcattcacaa tgcagttgaa 3720 gggggaaggc tccactgcat tctttggcta aggcctgaat gcttgctcat ctgtaagatc 3780 tatactcgag gttttgtttt ccttttaaaa ttctttaggg agagagggat ggtttctgag 3840 gggttctgaa agtatgattc aatgtgcaac atacaggtag gtcttcagca taagctgaaa 3900 tatatgcatg taaaaacttt gacatctttt tttttaattt tccactttct tcttaacttt 3960 acttctcttt ttgtcccccc cccatcttac agaagttgag gccaagggag aatggtaggc 4020 acagaagaaa catggcaaac tgctctgtgc tttcaaacca aagtgttccc cccaacccca 4080 aatttgtcta agcactggcc agtctgttgt gggcattgtt ttctacaacc aaattctggg 4140 tttttttctt ctttctttaa acatagaggt accaccacaa gggatgccct actctctcgc 4200 agctcttgaa agcatctgtt tgagggaaag gtctctgggc aagcaagtgg ttatttggat 4260 tgcttgcttc cctttttcca cctgggacat tgtaatcata aaataacagt aaattccaaa 4320 cctcaaaaac tattatggcc tgagcacagc tgaaatctag cagagtttaa ctcttctgcc 4380 tccatgtctg tcacttataa ttcaggttct gctgttggct tcagaacatg agcagaagaa 4440 tcgttttatg ctagttattg cattcatggt tgaaactcaa cttagggaaa gggttccaat 4500 gtattaagca atgggctgct tctccccaat cctccctaac aattcgttgt gtggacttct 4560 catctaaaag gttagtggct tttgcttggg atcagtgctc tctattgatg ttcttgctgg 4620 tctccagaca cattcctgtt gcattaagac ttgaaagact tgtagatgtg tgatgttcag 4680 gcacaggatg ctgaaagcta tgttactatt cttagtttgt aaattgtcct tttgatacca 4740 tcatcttgtt ttctttttgt aggtataaat aaaaacactg ttgacaataa aaaaaaaaaa 4800 aaaaa 4805 <210> 26 <211> 3676 <212> DNA <213> Homo sapiens <400> 26 gagtagaagt gatttggcct cataacttca cagtggttta ccactttgtt ctatgttctg 60 gttttgtaaa ggatagtact ggaatttgcg tctgaagacc aatattggtg taactcctgt 120 cagtatattg gtaaaatgta gcagaggcag gagtttggat gtttggatgg gattccctta 180 ggattctaca gccaataaag atcctatttc ctatgcatgt cccaggaatc agtaatcctc 240 ttttactctg ttgggatgag tctttttttg tttctgttca gagtggttac taacttcacc 300 ttctttcctc ttgctgtcat ctgcattcgt gcttcccacc tgttgttggc atgtccttta 360 ccttctcttt ccctgccaca tcaacctaca cactgactca tcattgacgt ggaagatgtg 420 gaagatgtca agtttgtgat caactatgac tatccaaaca gctcagagga ttatgtgcac 480 cgtattggcc gaacagcccg tagcaccaac aagggtaccg cctatacctt cttcacccca 540 gggaacctaa aacaggccag agagcttatc aaagtgctgg aagaggccaa tcaggctatc 600 aatccaaaac tgatgcagct tgtggaccac agaggaggcg gcggaggcgg gggtaagggt 660 ggtcgttctc gttaccggac cacttcttca gccaacaatc ccaatctgat gtatcaggat 720 gagtgtgacc gaaggcttcg aggagtcaag gatggtggcc ggagagactc tgcaagctat 780 cgggatcgta gtgaaaccga tagagctggt tatgctaatg gcagtggcta tggaagtcca 840 aattctgcct ttggagcaca agcaggccaa tacacctatg gtcaaggcac ctatggggca 900 gctgcttatg gcaccagtag ctatacagct caagaatatg gtgctggcac ttatggagct 960 agtagcacca cctcaactgg gagaagttca cagagctcta gccagcagtt tagtgggata 1020 ggccggtctg ggcagcagcc acagccactg atgtcacaac agtttgcaca gcctccggga 1080 gctaccaata tgataggtta catggggcag actgcctacc aataccctcc tcctcctccc 1140 cctcctcctc cttcacgtaa atgaaaccac tcaagtggta gtgactccag cagacttaat 1200 tacattttaa ggaacactgt ctttcctttt tttttcctct tcgccttttc tttttttttc 1260 cttttttctt tttttttttt taatttttcc ccccaaccat cgtgatttgt cttttcatgc 1320 agattagtta gaattcactg ccaggtttct tctgcccacc aaaatgatcc agtctggaat 1380 aacattttgt aaaaaaaaaa aaaatatata tatatatata tagctgactg gaagagatta 1440 atttcttccc ccaacttctt gcatgttgaa gatatttgag ctatttttca tctaaaagag 1500 taaggtatta ggcccttttg tgggagcccc atgttttgtt tttctgagtt ggtggggagg 1560 gagggagggg gagggctgaa ttgttttgca gaggaagatg gcatctgtgc tttaaatttc 1620 tcattactgg gttagaaaac aaagagggat tgccctgcac attttctttt gtgcttttaa 1680 atgtttctta agttggaaca ggtttcctcg ggcctgtttt gactgattgc tggagtgcat 1740 ttgatagtta aaaattacta attggtttta tttcccttca cactctgcct ccccacttct 1800 ccccccgtta ctgaaaaata accattttag tgtcaggcta gaaattgaat tgctgagttt 1860 tgtgtatcct ttaaattaaa aaccacaagt gtttattgta gtggttaaac tgtagcatct 1920 cagcatctgg gtggaagctg cctatatttc ttcccagttt aactggggac catctgtgaa 1980 attaattttc catccagaca gctgctgtga gcaaatgaac ataaatgctc gctggaaatt 2040 tactaaccag tttttatatt gacctgcagt gtaaaaagca catttaatta taaacaatat 2100 attcaaaatg ggcaaatttt attttcaaat gcagtgtaga gctagattaa aagcaactct 2160 ttgccaccta ctctgccctt ttggcaaagt taccttgaac aaagaatctt aagggtttat 2220 taagaactct ttattttctt cataccctgt tctctgcagt gctttctaac agcttctggg 2280 tgcagatttt cttcggcatc cttttgcact cagcttatta caggtaggta gtgcttaaga 2340 aaagtcatgg aggactaaag cctaagtcct tttcactttt cctccatctg aaggtaggtg 2400 agttcatcct cttcatggta atgctgtttt accaagactt tatagcagat ggacccagaa 2460 agaattttct gctattgtgt tcactacaac aggataggga catcagacag ccccagaaac 2520 cccttccaga tctgatatgg gactattaat ttttatgctg ttaattggta ttcattcaca 2580 atgcagttga agggggaagg ctccactgca ttctttggct aaggcctgaa tgcttgctca 2640 tctgtaagat ctatactcga ggttttgttt tccttttaaa attctttagg gagagaggga 2700 tggtttctga ggggttctga aagtatgatt caatgtgcaa catacaggta ggtcttcagc 2760 ataagctgaa atatatgcat gtaaaaactt tgacatcttt ttttttaatt ttccactttc 2820 ttcttaactt tacttctctt tttgtccccc ccccatctta cagaagttga ggccaaggga 2880 gaatggtagg cacagaagaa acatggcaaa ctgctctgtg ctttcaaacc aaagtgttcc 2940 ccccaacccc aaatttgtct aagcactggc cagtctgttg tgggcattgt tttctacaac 3000 caaattctgg gtttttttct tctttcttta aacatagagg taccaccaca agggatgccc 3060 tactctctcg cagctcttga aagcatctgt ttgagggaaa ggtctctggg caagcaagtg 3120 gttatttgga ttgcttgctt ccctttttcc acctgggaca ttgtaatcat aaaataacag 3180 taaattccaa acctcaaaaa ctattatggc ctgagcacag ctgaaatcta gcagagttta 3240 actcttctgc ctccatgtct gtcacttata attcaggttc tgctgttggc ttcagaacat 3300 gagcagaaga atcgttttat gctagttatt gcattcatgg ttgaaactca acttagggaa 3360 agggttccaa tgtattaagc aatgggctgc ttctccccaa tcctccctaa caattcgttg 3420 tgtggacttc tcatctaaaa ggttagtggc ttttgcttgg gatcagtgct ctctattgat 3480 gttcttgctg gtctccagac acattcctgt tgcattaaga cttgaaagac ttgtagatgt 3540 gtgatgttca ggcacaggat gctgaaagct atgttactat tcttagtttg taaattgtcc 3600 ttttgatacc atcatcttgt tttctttttg taggtataaa taaaaacact gttgacaata 3660 aaaaaaaaaa aaaaaa 3676 <210> 27 <211> 3071 <212> DNA <213> Homo sapiens <400> 27 ccgccatttt gtgagaagca aggtggcctc cacgtttcct gagcgtcttc ttcgcttttg 60 cctcgaccgc cccttgacca cagacatgtc tcgggatcgg ttccggagtc gtggcggtgg 120 cggtggtggc ttccacaggc gtggaggagg cggcggccgc ggcggcctcc acgacttccg 180 ttctccgccg cccggcatgg gcctcaatca gaatcgcggc cccatgggtc ctggcccggg 240 ccagagcggc cctaagcctc cgatcccgcc accgcctcca caccaacagc agcaacagcc 300 accaccgcag cagccaccgc cgcagcagcc gccaccgcat cagccgccgc cgcatccaca 360 gccgcatcag cagcagcagc cgccgccacc gccgcaggac tcttccaagc ccgtcgttgc 420 tcagggaccc ggccccgctc ccggagtagg cagcgcacca ccagcctcca gctcggcccc 480 gcccgccact ccaccaacct cgggggcccc gccagggtcc gggccaggcc cgactccgac 540 cccgccgcct gcagtcacct cggcccctcc cggggcgccg ccacccaccc cgccaagcag 600 cggggtccct accacacctc ctcaggccgg aggcccgccg cctccgcccg cggcagtccc 660 gggcccgggt ccagggccta agcagggccc aggtccgggt ggtcccaaag gcggcaaaat 720 gcctggcggg ccgaagccag gtggcggccc gggcctaagt acgcctggcg gccaccccaa 780 gccgccgcat cgaggcggcg gggagccccg cgggggccgc cagcaccacc cgccctacca 840 ccagcagcat caccaggggc ccccgcccgg cgggcccggc ggccgcagcg aggagaagat 900 ctcggactcg gaggggttta aagccaattt gtctctcttg aggaggcctg gagagaaaac 960 ttacacacag cgatgtcggt tgtttgttgg gaatctacct gctgatatca cggaggatga 1020 attcaaaaga ctatttgcta aatatggaga accaggagaa gtttttatca acaaaggcaa 1080 aggattcgga tttattaagc ttgaatctag agctttggct gaaattgcca aagccgaact 1140 ggatgataca cccatgagag gtagacagct tcgagttcgc tttgccacac atgctgctgc 1200 cctttctgtt cgtaatcttt caccttatgt ttccaatgaa ctgttggaag aagcctttag 1260 ccaatttggt cctattgaaa gggctgttgt aatagtggat gatcgtggaa gatctacagg 1320 gaaaggcatt gttgaatttg cttctaagcc agcagcaaga aaggcatttg aacgatgcag 1380 tgaaggtgtt ttcttactga cgacaactcc tcgtccagtc attgtggaac cacttgaaca 1440 actagatgat gaagatggtc ttcctgaaaa acttgcccag aagaatccaa tgtatcaaaa 1500 ggagagagaa acccctcctc gttttgccca gcatggcacg tttgagtacg aatattctca 1560 gcgatggaag tctttggatg aaatggaaaa acagcaaagg gaacaagttg aaaaaaacat 1620 gaaagatgca aaagacaaat tggaaagtga aatggaagat gcctatcatg aacatcaggc 1680 aaatcttttg cgccaagatc tgatgagacg acaggaagaa ttaagacgca tggaagaact 1740 tcacaatcaa gaaatgcaga aacgtaaaga aatgcaattg aggcaagagg aggaacgacg 1800 tagaagagag gaagagatga tgattcgtca acgtgagatg gaagaacaaa tgaggcgcca 1860 aagagaggaa agttacagcc gaatgggcta catggatcca cgggaaagag acatgcgaat 1920 gggtggcgga ggagcaatga acatgggaga tccctatggt tcaggaggcc agaaatttcc 1980 acctctagga ggtggtggtg gcataggtta tgaagctaat cctggcgttc caccagcaac 2040 catgagtggt tccatgatgg gaagtgacat gcgtactgag cgctttgggc agggaggtgc 2100 ggggcctgtg ggtggacagg gtcctagagg aatggggcct ggaactccag caggatatgg 2160 tagagggaga gaagagtacg aaggcccaaa caaaaaaccc cgattttaga tgtgatattt 2220 aggctttcat tccagtttgt tttgtttttt tgtttagata ccaatctttt aaattcttgc 2280 attttagtaa gaaagctatc tttttatgga tgttagcagt ttattgacct aatatttgta 2340 aatggtctgt ttgggcaggt aaaattatgt aatgcagtgt ttggaacagg agaatttttt 2400 tttccttttt atttctttat tttttctttt ttactgtata atgtccctca agtttatggc 2460 agtgtacctt gtgccactga atttccaaag tgtaccaatt tttttttttt tactgtgctt 2520 caaataaata gaaaaatagt tataatattg gatcttcaac tttgccattc atgcttctat 2580 gcatattagg ctacgtattc cacattgaaa gcatgagagt gtctaggcct ttgaatggca 2640 tatgccattt ctgggaaatg catctggagg ctaagtattg ctttctacaa ataattgccc 2700 cctttgtttt aaaaagaaga aatgcatatt gaagtagttt gatgatttgt ttggcatata 2760 ggaagcacgc tggtgctaag tattttttaa atggttatgt aagcaaagct gaactgtaaa 2820 tcttcaggaa tatgtattaa gattgtggaa tgggtgtaag acaattggta gggggtgaaa 2880 gtgggtttga ttaaatggat cttttatggc cctatgatct atcctttact tgaaagcttt 2940 tgaaaagtgg aaaggtcatt ttgttgcatt tccccatttc ttgtttttaa aagaccaaca 3000 aatctcaagc cctataaatg gcttgtattg aacttttaca tttgaattaa agatgttaaa 3060 catgaaaaaa a 3071 <210> 28 <211> 1329 <212> DNA <213> Homo sapiens <400> 28 ggcctgcagt ggacgagcat cgcatagcct gcggggctgg atgctgaccg cccgggccag 60 cacctaggcg gacgcggagc tgtgcagacc agggttcgcg cgggccgggt ggaggctcaa 120 gcggggaccc cggagcgtga gccccggagt cggcggcgct ggggccagag gggccgggag 180 ggagtcggct gaggtggcgg cggaggcgaa gtggcggcgg aggcgaaggg gcggcgggac 240 ccgggcctgg cccgtatgtg tccttggcgg cctagactag gccgtcgctg tatggtgagc 300 cccagggagg cggatctggg cccccagaag gacacccgcc tggatttgcc ccgtaggccc 360 ggcccgggcc cctcgggagc agaacagcct tggtgaggtg gacaggaggg gacctcgcga 420 gcagacgcgc gcgccagcga cagcagcccc gccccggcct ctcgggagcc ggggggcaga 480 ggctgcggag ccccaggagg gtctatcagc cacagtctct gcatgtttcc aagagcaaca 540 ggaaatgaac acattgcagg ggccagtgtc attcaaagat gtggctgtgg atttcaccca 600 ggaggagtgg cggcaactgg accctgatga gaagatagca tacggggatg tgatgttgga 660 gaactacagc catctagttt ctgtggggta tgattatcac caagccaaac atcatcatgg 720 agtggaggtg aaggaagtgg agcagggaga ggagccgtgg ataatggaag gtgaatttcc 780 atgtcaacat agtccagaac ctgctaaggc catcaaacct attgatcgga agtcagtcca 840 tcagatttgc tctgggccag tggtactgag tctaagcact gcagtgaagg agttagtaga 900 aaacagtctg gatgctggtg ccactaatat tgatctaaag cttaaggact atggagtgga 960 tctcattgaa gtttcagaca atggatgtgg ggtagaagaa gaaaactttg aaggcttaac 1020 gatgtcacca tttctacctg ccacgcgtcg gtgaaggttg ggactcgact ggtgtttgat 1080 cacgatggga aaatcatcca ggaaaccccc tacccccacc ccagagggac cacagtcagc 1140 gtgaagcagt tattttctac gctacctgtg cgccataagg aatttcaaag gaatattaag 1200 aagacgtgcc tgcttcccct tcgccttctg ccgtgattgt cagtttcctg aggcctcccc 1260 agccatgctt cctgtacagc ctgcagaact gtgagtcaat taaacctctt ttcttcataa 1320 attaaaaaa 1329 <210> 29 <211> 1334 <212> DNA <213> Homo sapiens <400> 29 ggcctgcagt ggacgagcat cgcatagcct gcggggctgg atgctgaccg cccgggccag 60 cacctaggcg gacgcggagc tgtgcagacc agggttcgcg cgggccgggt ggaggctcaa 120 gcggggaccc cggagcgtga gccccggagt cggcggcgct ggggccagag gggccgggag 180 ggagtcggct gaggtggcgg cggaggcgaa gtggcggcgg aggcgaaggg gcggcgggac 240 ccgggcctgg cccgtatgtg tccttggcgg cctagactag gccgtcgctg tatggtgagc 300 cccagggagg cggatctggg cccccagaag gacacccgcc tggatttgcc ccgtaggccc 360 ggcccgggcc cctcgggagc agaacagcct tggtgaggtg gacaggaggg gacctcgcga 420 gcagacgcgc gcgccagcga cagcagcccc gccccggcct ctcgggagcc ggggggcaga 480 ggctgcggag ccccaggagg gtctatcagc cacagtctct gcatgtttcc aagagcaaca 540 ggaaatgaac acattgcagg ggccagtgtc attcaaagat gtggctgtgg atttcaccca 600 ggaggagtgg cggcaactgg accctgatga gaagatagca tacggggatg tgatgttgga 660 gaactacagc catctagttt ctgtggggta tgattatcac caagccaaac atcatcatgg 720 agtggaggtg aaggaagtgg agcagggaga ggagccgtgg ataatggaag gtgaatttcc 780 atgtcaacat agtccagtac agaacctgct aaggccatca aacctattga tcggaagtca 840 gtccatcaga tttgctctgg gccagtggta ctgagtctaa gcactgcagt gaaggagtta 900 gtagaaaaca gtctggatgc tggtgccact aatattgatc taaagcttaa ggactatgga 960 gtggatctca ttgaagtttc agacaatgga tgtggggtag aagaagaaaa ctttgaaggc 1020 ttaacgatgt caccatttct acctgccacg cgtcggtgaa ggttgggact cgactggtgt 1080 ttgatcacga tgggaaaatc atccaggaaa ccccctaccc ccaccccaga gggaccacag 1140 tcagcgtgaa gcagttattt tctacgctac ctgtgcgcca taaggaattt caaaggaata 1200 ttaagaagac gtgcctgctt ccccttcgcc ttctgccgtg attgtcagtt tcctgaggcc 1260 tccccagcca tgcttcctgt acagcctgca gaactgtgag tcaattaaac ctcttttctt 1320 cataaattaa aaaa 1334 <210> 30 <211> 1430 <212> DNA <213> Homo sapiens <400> 30 ggggcactga ggagcggcgc ccgcggggca gcgaggagcc cgatgcaggg ttctgcgcgt 60 catttccggt cccgcgggcg ccccgtgaag cccacctgga tccgccagcg ctgtgccact 120 ccccagtgcc gagctccgag ctgtctccgc ggcctcgcgc ccggcccctc caccgcgcac 180 ctcttaggcc ccgcccgcca gcgtcccttt gttgtgaagg cgccggggcc tagcgctatg 240 cctgcggcgg agactgcatc aggctctcgc gtctgcttct acgctttgcc tgggagaggc 300 cctggtggcc tcgttcctgg cgcccggagt ccctgctgcg gccccacccc cgggcggtca 360 cggtgaccca tgctgcccag cctggaggta aaatcgttcg tggctgtggc ttcagcatgt 420 cgtcctcggt gaaaacccca gcactggaag agctggttcc tggctccgaa gagaagccga 480 aaggcaggtc gcctctcagc tggggctctc tgtttggtca ccgaagtgag aagattgttt 540 ttgccaagag cgacggcggc acagatgaga acgtactgac cgtcaccatc acggagacca 600 cggtcatcga gtcagacttg ggtgtgtgga gctcgcgggc gctgctctac ctcacgctgt 660 ggttcttctt cagcttctgc acgctcttcc tcaacaagta catcctgtcc ctgctgggag 720 gcgagcccag catgctaggt gcggtgcaga tgctgtccac cacggttatc gggtgtgtga 780 aaaccctcgt tccttgctgt ttatatcagc acaaggcccg gctttcctac ccacccaact 840 tccttatgac gatgctgttt gtgggtctga tgaggtttgc aactgtggtt ttgggtttgg 900 tcagcctgaa aaatgtggcg gtttcgtttg ctgagacggt gaagagctcc gcccccatct 960 tcacggtgat catgtctcgg atgattctgg gggagtacac aggacgtccc agtgatcggg 1020 aggagcggga agagcttcag ctacaaccag gacgtggtgc tgctgcttct gacagacgga 1080 gtcctgttcc accttcagag cgtcacggcg tacgccctca tggggaaaat ctccccggtg 1140 actttcaggt cccgcaggcc ctgcaccgag tcgccttgtc catggcgctg ccctgcccca 1200 tgcttcctgc gtcctgagta ggaggtatct ccgagacagg aaaagtggcc gctctctctc 1260 actttttctg gaactcatgg tggtctcctg ggcttggtca ctgtctctca ccagcatgtt 1320 tctttgtgcg gtcaggaatt atttccaaat gctcctgaag cctagtgttt tagtgaacat 1380 tagtgattgt tagcagtggt tcaaaaaaaa aaaacttttt tttttttttt 1430 <210> 31 <211> 1082 <212> DNA <213> Homo sapiens <400> 31 gactcgactg gtgtttgatc acgatgggaa aatcatccag aaaaccccct acccccaccc 60 cagagggacc acagtcagcg tgaagcagtt attttctaca ctacctgtgc gccataagga 120 atttcaaagg aatgttaaga agacgtgcct gcttcccctt cgccttctgc cgtgattgtc 180 agtttcctga ggcctcccca gccatgcttc ctgtacagcc tgcagaactt acagaacctg 240 ctaaggccat caaacctatt gatcggaagt cagtccatca gatttgctct gggccagtgg 300 tactgagtct aagcactgca gtgaaggagt tagtagaaaa cagtctggat gctggtgcca 360 ctaatattga tctaaagctt aaggactatg gaatggatct cattgaagtt tcaggcaatg 420 gatgtggggt agaagaagaa aacttcgaag gcttaatctc tttcagctct gaaacatcac 480 acatctaaga ttcaagagtt tgccgaccta actcgggttg aaacttttgg ctttcggggg 540 aaagctctga gctcactttg tgcactgagt gatgtcacca tttctacctg ccacgtatcg 600 gcgaaggttg ggactcgact ggtgtttgat cacgatggga aaatcatcca gaaaaccccc 660 tacccccacc ccagagggac cacagtcagc gtgaagcagt tattttctac gctacctgtg 720 cgccataagg aatttcaaag gaatattaag aagaaacgtg cctgcttccc cttcgccttc 780 tgccgtgatt gtcagcttct tgagggctcc ccagccatgc ttcctgtaca gcctgcaaaa 840 ctgatgtaac tggagagcta cgggcatgca gaagttggaa gacgagggaa ggcatcacag 900 aggctgtgag gtgaaccgac ttcaaggaat gggtccttcc cttcagagcc acatgtgtgc 960 gggacaccca gacagaaaac acaaatgcaa agtcaagtgg agggcatttg gaaggagcag 1020 tgaagccaag ccaggaaaca ccaagatggc gagccagtgt ggttgtagag attgtagaga 1080 gg 1082 <210> 32 <211> 1946 <212> DNA <213> Homo sapiens <400> 32 agacactgcc cgctctccgg gactccgcgc cgctccccgt tgccttccag gactgagaaa 60 ggggaaaggg aagggtgcca cgtccgagca gccgccttga ctggggaagg gtctgaatcc 120 cacccttggc attgcttggt ggagactgag atacccgtgc tccgctcgcc tccttggttg 180 aagatttctc cttccctcac gtgatttgag ccccgttttt attttctgtg agccacgtcc 240 tcctcgagcg gggtcaatct ggcaaaagga gtgatgcgct tcgcctggac cgtgctcctg 300 ctcgggcctt tgcagctctg cgcgctagtg cactgcgccc ctcccgccgc cggccaacag 360 cagcccccgc gcgagccgcc ggcggctccg ggcgcctggc gccagcagat ccaatgggag 420 aacaacgggc aggtgttcag cttgctgagc ctgggctcac agtaccagcc tcagcgccgc 480 cgggacccgg gcgccgccgt ccctggtgca gccaacgcct ccgcccagca gccccgcact 540 ccgatcctgc tgatccgcga caaccgcacc gccgcggcgc gaacgcggac ggccggctca 600 tctggagtca ccgctggccg ccccaggccc accgcccgtc actggttcca agctggctac 660 tcgacatcta gagcccgcga agctggcgcc tcgcgcgcgg agaaccagac agcgccggga 720 gaagttcctg cgctcagtaa cctgcggccg cccagccgcg tggacggcat ggtgggcgac 780 gacccttaca acccctacaa gtactctgac gacaaccctt attacaacta ctacgatact 840 tatgaaaggc ccagacctgg gggcaggtac cggcccggat acggcactgg ctacttccag 900 tacggtctcc cagacctggt ggccgacccc tactacatcc aggcgtccac gtacgtgcag 960 aagatgtcca tgtacaacct gagatgcgcg gcggaggaaa actgtctggc cagtacagca 1020 tacagggcag atgtcagaga ttatgatcac agggtgctgc tcagatttcc ccaaagagtg 1080 aaaaaccaag ggacatcaga tttcttaccc agccgaccaa gatattcctg ggaatggcac 1140 agttgtcatc aacattacca cagtatggat gagtttagcc actatgacct gcttgatgcc 1200 aacacccaga ggagagtggc tgaaggccac aaagcaagtt tctgtcttga agacacatcc 1260 tgtgactatg gctaccacag gcgatttgca tgtactgcac acacacaggg attgagtcct 1320 ggctgttatg atacctatgg tgcagacata gactgccagt ggattgatat tacagatgta 1380 aaacctggaa actatatcct aaaggtcagt gtaaacccca gctacctggt tcctgaatct 1440 gactatacca acaatgttgt gcgctgtgac attcgctaca caggacatca tgcgtatgcc 1500 tcaggctgca caatttcacc gtattagaag gcaaagcaaa actcccaatg gataaatcag 1560 tgcctggtgt tctgaagtgg gaaaaaatag actaacttca gtaggattta tgtattttga 1620 aaaagagaac agaaaacaac aaaagaattt ttgtttggac tgttttcaat aacaaagcac 1680 ataactggat tttgaacgct taagtcatca ttacttggga aatttttaat gtttattatt 1740 tacatcactt tgtgaattaa cacagtgttt caattctgta attacatatt tgactctttc 1800 aaagaaatcc aaatttctca tgttcctttt gaaattgtag tgcaaaatgg tcagtattat 1860 ctaaatgaat gagccaaaat gactttgaac tgaaactttt ctaaagtgct ggaactttag 1920 tgaaacataa taataatggg tttata 1946 <210> 33 <211> 1819 <212> DNA <213> Homo sapiens <400> 33 tattcaataa ggactgttat ttctagtata gagaggaggg ctcctaggcc tggctaagca 60 gtttaagata aaatgcaaaa tgacccaatt caggatgatt atagttggtt taaatttggt 120 tgctgaggca caaacaaaag tgttggattc tgtagttttt gttgtgatta cagaacacat 180 gcagtatctt ccagaaccct ttgataaagc tgaagtaagg atgggctcac atggcccatg 240 tgagtaagaa gctgtgttga cagagtggac gataccttca attatggctt aacaaaaaat 300 gcctgaaaat ggaataactt agaaggaact cttcctttaa aggatttaat ggcaggtgca 360 gtggcttacg cctgtaatcc cagcactttg ggagcctgag gcagaagatg gcttgagccc 420 aggagtttga ggcagcggtg agccataatc ataccactgc acttaagcct gggcaacaca 480 atgagaccct gtctcctgtc tttaaaaaaa agagacagag acctacctgt atgctaggag 540 catccttctc actgtaggtc ggatgtggtg gttctgtttt aaatttgctg aattgtgact 600 ttttttcttt ttcttttttt tttttttttt tttgtttttt tttgaggcag ggtctcactc 660 tgtcgcccag gctggagtgc agtggtgtga tctcggctca cttcaacctc cacctcctgg 720 gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc gtgcaccacc 780 atgcctggct aatttttgta tttttagtag agatggggtt tcacaatgtt gcccaggttg 840 gtctcgaacc gctgacctta agcgatccgc ctgccttggc ctccccaagg tgctggaatt 900 acaggcatga gccaccgcgc ccggctgact tttttttttt ctttctttct ttttgagaca 960 gagttttgct cagtctccca ggctggagtg caatggcaac aacatggctc gctgcagcct 1020 caatctgctg tgctcaggta ttcctcctgc ctcagcctcc tgagtagctg ggactacagg 1080 cgcatgccac cacacctggc tattgtggat tttaagaaat tttttttgta gagacagggt 1140 cttactatgt tgcccaggtt gttcttgaac tcttgggctc cagagagcct cccatctcag 1200 cctcccaaag tgctgagatt ataggcgtga gccaccacac ttagcctatt gtgacttttt 1260 agagtctcta atactttctt ttagggcact aaaaacttaa tcttagatcc agttggtatt 1320 catttgggtg aatgaagtgg tagggaccta ccttaatttt ttttccaggt ttttgtgatt 1380 gaataagttc cagatactca aagcgaccta gatcagtgat gaaatttttg actgcatttg 1440 gacctatttc tgggatctcc ttttactgat ttctctgtat attcatgagc aaccttaaat 1500 tattttagac tatttaatta ttatgttcta ttttctggaa agttttgtcc ttcactcttc 1560 tttttcaaaa ttttcctgat tgttatttca taaatatttt ttcacagaat caactggttt 1620 tgaacctcaa tttacttata ggttaattta gagagaattg acttttaaaa ttatattaaa 1680 ggccaggcat ggtagctcat gcttataatc ctggcatttt ggggggctga ggcagatgga 1740 tcacatgatc ccaggatttg agactggcct gggcaacata gtgagatctc atctcttaaa 1800 aaaaaaaaaa aaaaaaaaa 1819 <210> 34 <211> 3609 <212> DNA <213> Homo sapiens <400> 34 gagccgcggc cgcgcggagg aagcgaagga ggcgggagcg gagacctcgc tgcgctcatg 60 gcgtcgcccg ggcattcaga tttgggagaa gtagccccag aaataaaagc atcagagaga 120 cgaacagctg tggccattgc agatttggaa tggagagaaa tggaaggaga tgattgcgag 180 ttccgttatg gagatggtac aaatgaggct caggacaatg attttccaac agtggagaga 240 agcaggcttc aagaaatgct gtcacttttg ggcctagaga cgtaccaggt ccagaaactc 300 agcctccagg actctctgca gatcagtttt gacagtatga agaactgggc ccctcaggtt 360 cccaaagact tgccctggaa tttcctcagg aagttgcagg ccctcaatgc tgatgccagg 420 aataccacta tggtgctgga cgtgctccca gacgccaggc ctgtggagaa ggagagccag 480 atggaagagg agatcatcta ctgggaccca gctgatgacc ttgctgccga catttattcc 540 ttttctgagc tgcccacccc tgatacgcca gtgaacccct tagaccttct ctgtgccctg 600 ctgctctcct cagacagttt cctgcaacaa gaaatagcgt tgaaaatggc cctctgccag 660 tttgcactcc cactcgtgtt gcctgactcg gagaaccact accatacatt tctgctgtgg 720 gccatgcggg gcattgtgag gacatggtgg tcccagcccc caaggggcat ggggagcttc 780 cgggaagaca gcgtggtctt gtccagggcg cccgccttcg ccttcgtgcg catggacgtc 840 agtagcaact ccaagtccca gcttctcaac gccgtcctca gcccgggcca caggcagtgg 900 gactgcttct ggcatcggga cctcaacttg ggcaccaatg cccgggagat ttcggatggg 960 ttggtagaaa tttcctggtt ttttcccagc ggaagggagg acttggacat tttcccagaa 1020 cctgtggcct ttctgaacct gagaggtgac atcgggtctc actggctgca gtttaagctc 1080 ttgacagaaa tctcctccgc tgtgtttata ttgactgaca atatcagtaa gaaggaatac 1140 aaattgctgt actccatgaa ggagtcaacc acaaaatact acttcatcct gagtccctac 1200 cgtgggaagc gcaacacaaa cctgagattt ctgaataagt taattcctgt gctgaaaata 1260 gaccactcac atgtcctggt aaaggtcagc agcactgaca gcgacagctt cgtgaagagg 1320 atccgggcca tcgttgggaa tgtgctgcgg gcaccctgca ggcgggtatc tgtggaggac 1380 atggcgcacg cagcccgcaa actgggccta aaggtcgacg aggactgtga ggagtgtcag 1440 aaagcgaaag accggatgga gaggattacc aggaaaatca aagactcgga tgcctacaga 1500 agggacgagc tgaggctgca gggggacccc tggagaaagg cagcccaagt ggagaaggag 1560 ttctgccagc tccagtgggc cgtggacccc cctgagaagc acagggctga gctgaggcgg 1620 cggctgctag aacttcgaat gcagcagaac ggccatgatc cctcctcggg ggtgcaggag 1680 ttcatctcgg ggatcagcag cccctccttg agtgagaagc agtacttcct gaggtggatg 1740 gagtggggcc tggcacgggt ggcccagccg cgactgagac agcctccgga gacgcttctc 1800 accctgagac caaagcatgg gggcaccaca gacgtggggg agccgctctg gcctgagccc 1860 ctaggggtgg aacacttctt gcgggagatg ggacagtttt atgaggctga gagctgtctt 1920 gtggaggcag ggaggctgcc ggcaggccag aggcgttttg cccacttccc aggcttggcc 1980 tcggagctgc tgctgacagg gctgcctctg gagctaatcg atgggagcac gctgagcatg 2040 cccgtccgct gggtcacagg gctcctgaag gagctgcacg tccgactgga gagacggtca 2100 aggctggtgg ttctgtcaac cgtcggggtg ccaggcacgg gcaagtccac actcctcaac 2160 accatgtttg ggctgcggtt tgccacaggg aagagctgcg gtcctcgagg ggccttcatg 2220 cagctcatca cagtggctga gggcttcagc caggacctgg gctgtgacca catcctggtg 2280 atagactccg ggggcttgat aggtggggcc ttgacgtcag ctggggacag atttgagctg 2340 gaggcttcct tggccactct gctcatggga ctgagcaatg tcaccgtgat cagtctagct 2400 gaaaccaagg acattccagc agctattctg catgcatttc tgaggttaga aaaaacgggg 2460 cacatgccca actaccagtt tgtataccag aaccttcatg atgtatctgt tcccggccct 2520 aggcccagag acaagagaca gctcctggat ccacctggtg acctgagcag ggctgcagcc 2580 cagatggaga aacagggcga cggcttccgg gcactggcag gcctggcctt ctgcgaccct 2640 gagaagcagc acatctggca catcccaggc ctgtggcacg gagcacctcc catggccgca 2700 gtgagcttgg cctacagtga agccatattt gaattgaaga gatgcctact cgaaaacatc 2760 aggaacggct tgtcgaacca aaacaaaaac atccagcagc tcattgagct ggtgagacgg 2820 ctgtgagtgt gcagagaaac ccagttcagg tgtaggaggc tgctgtgggc agccctgtct 2880 gatggggcac ccgtgtgggg ctgtgctctg gtgcctgaga atggctggtg cccaatcgac 2940 atgagaagac gaggaaaaga cagggtttgg agtctcctca acagtgttaa aagaggaagt 3000 gacctcacag accagctcag agatgttacc aagaatatca cagcccccag ggtagggaga 3060 caagcagcag tttgttctgt ctcagctcct gtcaaggatc ctgcggggtg ggccctctgt 3120 atagctgctc tctgtcactg gcccctggag tgggagcagc gtccttagtc actgcaggcc 3180 caggcgggca ggtggtccca ggacagaggt ggggaagttg tcctgaggaa gcagaagtag 3240 gccttgctcc cgcccaaccc aagggcctcc agtggaccag cattcaagat gtgagtgccc 3300 gtggtgtgca aggcactccc atggcaccgt atttattgac tgatctgtga aggcttccct 3360 gacccctgcc caggaagagt tcactggtcg ctctgttgtg ccccacagca ctttgttata 3420 cctctgccac acacttcacg cagcgcgttg taactcatgt gtttacatgt ctgtcccccc 3480 agactgtgag ctccttgagg gcagggactg tacattctcc agctctgtgt ccccagggcc 3540 tggcacattg tagacgctta ataaatgtct gttaaatgaa tgagtgcaca aaaaaaaaaa 3600 aaaaaaaaa 3609 <210> 35 <211> 4976 <212> DNA <213> Homo sapiens <400> 35 gggcgggcgg gccgcaggct gtcgggctgg ggctgaggct gaggctgagg ttgaggcggc 60 ggcggcggcg gccgggtgcc cgggacagcg acgcagcgcg ccggcggccg cgacagggcc 120 agcgagagcc ccgcagcccg ccgcagctgc cgcctcgccg cggccgggcc ggagagcacg 180 gcggcgggag cgcggcctta ggaggcggcc ggagcggtgg gcacagctcg gcgcggagcg 240 tcctgtcagg cggcggccga gggcgtcgcg gactctcccc gcgatgatgc cgatgatatt 300 aactgttttc ttgagcaaca atgaacagat tttaacagaa gttcctataa caccggaaac 360 aacctgtcga gatgttgtag aattttgcaa ggaacctgga gaaggcagct gccatttagc 420 tgaagtgtgg aggggaaatg aacgtcccat accctttgat catatgatgt acgaacatct 480 tcagaaatgg ggtccacgga gggaagaagt gaaatttttc cttcgacacg aggactcccc 540 aactgagaac agtgaacaag gtggccgtca gacccaagag caacgaactc agagaaatgt 600 aataaatgta cctggagaaa aacgtactga aaatggggtt gggaatccac gtgttgaact 660 taccctctca gagctccaag atatggcagc taggcaacag cagcagattg aaaatcagca 720 gcagatgttg gttgccaagg aacagcgttt acattttcta aagcaacagg agcgccgtca 780 gcagcagtct atttctgaaa atgaaaagct tcagaaattg aaagaacgag ttgaagccca 840 ggagaacaag ctgaagaaaa ttcgtgcaat gagaggacaa gtcgactaca gcaaaatcat 900 gaacggcaat ctgtctgctg aaatagaaag gttcagtgcc atgttccagg aaaagaagca 960 ggaagtacag actgcaattt taagggttga tcagcttagt cagcaattgg aagatttaaa 1020 gaaaggaaaa ctgaatgggt tccagtctta caatggcaaa ttgacgggac cagcggcggt 1080 ggagttaaaa agactgtacc aagaactaca gattcgtaac caacttaacc aggaacaaaa 1140 ttcaaaactt cagcagcaga aggaactctt aaataagcgc aacatggagg tggccatgat 1200 ggacaagcga atcagtgaac tgcgtgaacg tctctatggg aaaaaaattc agctgaaccg 1260 tgtgaatggc acgtcatcac cacagtcccc tctgagcaca tcgggcaggg tcgctgctgt 1320 ggggccttat atccaggttc ccagtgccgg aagctttcct gtgctggggg accctataaa 1380 gccccagtct ctcagtattg cctcaaatgc tgctcatgga agatccaaat ccgctaatga 1440 tggaaactgg ccaacattaa aacagaattc tagctcttcc gtgaaaccag tgcaggtggc 1500 cggtgcagac tggaaggatc cgagcgtgga ggggtctgtc aagcagggca ctgtctccag 1560 ccagcctgtg cccttctcag cactgggacc cacggagaag ccgggcatcg agattggtaa 1620 agtgccacct cccatcccgg gtgtaggcaa gcagctgcct ccaagctatg ggacataccc 1680 aagtcctaca cctctgggtc ctgggtcgac aagctccctg gaaaggagga aggaaggcag 1740 cttgcccagg cccagtgcag gcctgccaag tcgacagagg cccaccctgc tgcccgccac 1800 aggcagcacc ccccagccag gctcctcaca acagattcag cagaggattt ccgtaccgcc 1860 aagtcccacg tacccgccag cgggaccacc tgcatttcca gctggggaca gcaagcctga 1920 actcccactg acagtggcca ttaggccttt cctggctgat aaagggtcaa ggccacagtc 1980 tcccaggaaa ggaccccaga cagtgaattc aagttccata tactccatgt acctccagca 2040 agccacacca cctaagaatt accagccggc agcacacagc gccttaaata agtcagttaa 2100 agcagtgtat ggtaagcccg ttttaccttc gggttcaacc tctccatcgc cgctgccgtt 2160 tcttcacggg tcactgtcca cgggcacacc acagcctcag ccaccttcag aaagtactga 2220 gaaagagcct gagcaggatg gccccgccgc ccccgcagat ggcagcaccg tggagagcct 2280 gccacggcca ctcagcccca ccaagctcac gcccatcgtg cattcgccac tgcgctacca 2340 gagtgatgca gacctggagg ccctccgcag gaagctggcc aacgcgcccc ggcccctgaa 2400 aaagcgcagc tccatcacag agcccgaggg ccccggcggg cccaacatcc agaagctgct 2460 gtaccagcgc ttcaacaccc tggccggtgg catggagggc acccctttct accagcccag 2520 cccctcccag gacttcatgg gcaccttggc cgatgtggac aatggaaaca ccaatgccaa 2580 tggaaacctg gaagagctcc cccctgccca gcccacagcc ccactccccg ctgagcctgc 2640 cccgtcatca gatgccaatg ataatgagtt accttccccc gaaccagagg agctcatctg 2700 tccccaaacc acccaccaaa ctgccgagcc ggcagaggac aataacaaca acgtggccac 2760 ggtccccacc acggagcaga tcccgagtcc tgtggctgag gccccatctc caggggaaga 2820 gcaggtccct ccagcacctc ttccccctgc cagccaccct cctgccacct ccacgaacaa 2880 gcggaccaac ttgaagaagc ccaactcgga gcggacgggg cacgggctga gagtccggtt 2940 taaccccctg gcactgctcc tagacgcgtc tctggaagga gagttcgatc tggtgcagag 3000 gatcatctat gaggtggaag atcccagcaa gcccaacgac gaagggatca ccccactgca 3060 caacgccgtc tgcgccggcc accatcacat cgtgaagttc ctgctggatt ttggtgtcaa 3120 cgtgaatgct gctgatagtg atggatggac gccgctgcac tgcgctgcct cttgtaacag 3180 cgttcacctc tgcaaacagc tggtggagag tggtgccgcc atttttgcct caaccataag 3240 cgacattgaa actgctgcag acaagtgtga ggagatggag gaaggctaca tccagtgctc 3300 ccagtttcta tatggggtgc aggaaaagct gggtgtgatg aacaaaggtg tggcgtatgc 3360 tctgtgggac tacgaggccc agaacagtga cgagctgtcc ttccacgaag gggacgccct 3420 caccatcctg aggcgcaagg acgaaagcga gactgagtgg tggtgggctc gccttggaga 3480 ccgggagggc tatgtgccca aaaacctgct ggggctgtat ccacggatca aaccccgaca 3540 gcgaacactc gcctgaactt ccttttggag caccgcatgg tcttgccagc taccaggagc 3600 cacttaagag attattgtgc tgttttccag gaaagctgca gctagaaaat ggtcttaatg 3660 gtgctcactt tagcagacag cgtccacaat gtgaatccta cagtttccag gtgaggccct 3720 ttctccagtt tgcccattaa ctgggagagg tactttcgcc tccaaggact gaattttgcc 3780 aattactata aatccaaata aatacccact ttcaaaacac ccacccctct tgccattaag 3840 aagtcccata acccccggtt ggttgccagt gaagacagaa gctcttactg acttggcccc 3900 gaggccatca ccccctccag cagtgaacac tgtccgccgc tgtgaggcct gctcccctgc 3960 gaccgccctg ccccccgtca ccgaatcgga cactcatcct ttctcacact tcccacacat 4020 gatccttctt cccttcatca ccaaaggagc ctctgtatgg aaacatgtcc agtgttgctg 4080 cccagtgtgt atgcctccca gtacccactc tgctcggccg ccttgggggt tccgcttcct 4140 gttccagttc acctaaaggc tgattgtgca ggcccagcac tgtggctgga ctgccgcgcc 4200 acgggcacca ggacccctaa gaccaagtga caactgggag agcctcagca tatactcttc 4260 tcctccgatc tcacagcctg tcatgctgct cagtgtggtt ctcacccctg caagctcaaa 4320 ttcagttccc tgaatggagt caggtgctgg aggccgtggc agcggagggt ggttggggtt 4380 ggggctgggg gtggactggt gtgagggcag accagggcca ggtagacggg gctgtttggt 4440 gcctgaagga tggcagacgc ctggtgtcag gaggggccgc caccaaggag cagcagctgg 4500 ggcagaggag ctggggtcag gggccacccc tctctgccga tctccctgcc tgggctggct 4560 gtgaggccac ctttgtccca ggcccagcct caaggcaagg agggcgcttc actgaggtgt 4620 gaattgtacg tacaggcttt ttatatacca aaagtatttt ttgactagac cattcaaagc 4680 tacccgaact atgttggaaa tttttttttt ctcattaaaa tacaggccct taggctctat 4740 ttttcatgta tgagtcgtgt gtaatttatg taaaaatgtg tgtacagact cactgatgca 4800 gcactgtagc ccatcacctt ggagcactga ctgtacatag tgtggtgaag aaaagtgaac 4860 gcccttgtag agcagcccga ccacaggagc atggccgctg ccagcccaga cgctgctgac 4920 gctgtgtaaa tgtgcacaat aaacccgtct caccccggca aaaaaaaaaa aaaaaa 4976 <210> 36 <211> 6659 <212> DNA <213> Homo sapiens <400> 36 cgcgcgggcg cgggggacgg cgcaggggcc gcctggctgg agcagccaga ggggatagct 60 tcgtcgagaa cggaggacac cggcggtcca gggtcctggg cagtcgcgcc agagctgagc 120 ggagggcgcg gcgcgagaac gaatctttgt gacattctct ctcagcattc tttatcccct 180 gtttgctgaa gacttcgaca aaagctggtc ttagctgttg gcattctcct gagaaaagga 240 tagcttcaga aatcagaaaa acatttggga ggtgtctagc ccagtggacc ttctgaagag 300 caatgctaag aagacgtttg gtttaaagaa ttaaaaggaa gaacaactta agagcttctt 360 caaagtttcc cgcatgaaaa ttacttaaac gttgcacaca acgtttcaca aaatcttttg 420 tgaaagaaga aaaggaaatt cagtgtgtga gtctcagcag gagttaagct aatgcagctt 480 aaaataatgc cgaaaaagaa gcgcttatct gcgggcagag tgcccctgat tctcttcctg 540 tgccagatga ttagtgcact ggaagtacct cttgatccaa aacttcttga agacttggta 600 cagcctccaa ccatcaccca acagtctcca aaagattaca ttattgaccc tcgggagaat 660 attgtaatcc agtgtgaagc caaagggaaa ccgcccccaa gcttttcctg gacccgtaat 720 gggactcatt ttgacatcga taaagaccct ctggtcacca tgaagcctgg cacaggaacg 780 ctcataatta acatcatgag cgaagggaaa gctgagacct atgaaggagt ctatcagtgt 840 acagcaagga acgaacgcgg agctgcagtt tctaataaca ttgttgtccg cccatccaga 900 tcaccattgt ggaccaaaga aaaacttgaa ccaatcacac ttcaaagtgg tcagtcttta 960 gtacttccct gcagaccccc aattggatta ccaccaccta taatattttg gatggataat 1020 tcctttcaaa gacttccaca aagtgagaga gtttctcaag gtttgaatgg ggacctttat 1080 ttttccaatg tcctcccaga ggacacccgc gaagactata tctgttatgc tagatttaat 1140 catactcaaa ccatacagca gaagcaacct atttctgtga aggtgatttc agtggatgaa 1200 ttgaatgaca ctatagctgc taatttgagt gacactgagt tttatggtgc taaatcaagt 1260 agagagaggc caccaacatt tttaactcca gaaggcaatg caagtaacaa agaggaatta 1320 agaggaaatg tgctttcact ggagtgcatt gcagaaggac tgcctacccc aattatttac 1380 tgggcaaagg aagatggaat gctacccaaa aacaggacag tttataagaa ctttgagaaa 1440 accttgcaga tcattcatgt ttcagaagca gactctggaa attaccaatg tatagcaaaa 1500 aacgcattag gagccatcca ccataccatt tctgttagag ttaaagcggc tccatactgg 1560 atcacagccc ctcaaaatct tgtgctgtcc ccaggagagg atgggacctt gatctgcaga 1620 gctaatggca accccaaacc cagaattagc tggttaacaa atggagtccc aatagaaatt 1680 gcccctgatg accccagcag aaaaatagat ggcgatacca ttattttttc aaatgttcaa 1740 gaaagatcaa gtgcagtcta tcagtgcaat gcctctaatg aatatggata tttactggca 1800 aacgcatttg taaatgtgct ggctgagcca ccacgaatcc tcacacctgc aaacacactc 1860 taccaggtca ttgcaaacag gcctgcttta ctagactgtg ccttctttgg gtctcctctc 1920 ccaaccatcg agtggtttaa aggagctaaa ggaagtgctc ttcatgaaga tatttatgtt 1980 ttacatgaaa atggaacttt ggaaattcct gtggcccaaa aggacagtac aggaacttat 2040 acgtgtgttg caaggaataa attagggatg gcgaagaatg aagttcactt agaaatcaaa 2100 gatcctacat ggatcgttaa acagcccgaa tatgcagttg tgcaaagagg gagcatggtg 2160 tcctttgaat gcaaagtgaa acatgatcac accttatccc tcactgtcct gtggctgaag 2220 gacaacaggg aactgcccag tgatgaaagg ttcactgttg acaaggatca tctagtggta 2280 gctgatgtca gtgacgatga cagcgggacc tacacgtgtg tggccaacac cactctggac 2340 agcgtctccg ccagcgctgt gcttagcgtt gttgctccta ctccaactcc agctcccgtt 2400 tacgatgtcc caaatcctcc ctttgactta gaactgacag atcaacttga caaaagtgtt 2460 cagctgtcat ggaccccagg cgatgacaac aatagcccca ttacaaaatt catcatcgaa 2520 tatgaagatg caatgcacaa gccagggctg tggcaccacc aaactgaagt ttctggaaca 2580 cagaccacag cccagctgaa gctgtctcct tacgtgaact actccttccg cgtgatggca 2640 gtgaacagca ttgggaagag cttgcccagc gaggcgtctg agcagtattt gacgaaagcc 2700 tcagaaccag ataaaaaccc cacagctgtg gaaggactgg gatcagagcc tgataatttg 2760 gtgattacgt ggaagccctt gaatggtttc gaatctaatg ggccaggcct tcagtacaaa 2820 gttagctggc gccagaaaga tggtgatgat gaatggacat ctgtggttgt ggcaaatgta 2880 tccaaatata ttgtctcagg cacgccaacc tttgttccat acctgatcaa agttcaggcc 2940 ctgaatgaca tggggtttgc ccccgagcca gctgtagtca tgggacattc tggagaagac 3000 ctcccaatgg tggctcctgg gaacgtgcgt gtgaatgtgg tgaacagtac cttagccgag 3060 gtgcactggg acccagtacc tctgaaaagc atccgaggac acctacaagg ctatcggatt 3120 tactattgga agacccagag ttcatctaaa agaaacagac gtcacattga gaaaaagatc 3180 ctcaccttcc aaggcagcaa gactcatggc atgttgccgg ggctagagcc ctttagccac 3240 tacacactga atgtccgagt ggtcaatggg aaaggggagg gcccagccag ccctgacaga 3300 gtctttaata ctccagaagg agtccccagt gctccctcgt ctttgaagat tgtgaatcca 3360 acactggact ctctcacttt ggaatgggat ccaccgagcc acccgaatgg cattttgaca 3420 gagtacacct taaagtatca gccaattaac agcacacatg aattaggccc tctggtagat 3480 ttgaaaattc ctgccaacaa gacacggtgg actttaaaaa atttaaattt cagcactcga 3540 tataagtttt atttctatgc acaaacatca gcaggatcag gaagtcaaat tacagaggaa 3600 gcagtaacaa ctgtggatga agctggtatt cttccacctg atgtaggtgc aggcaaagtt 3660 caagcagtaa atcccaggat cagcaatctt actgctgcag ctgctgagac ctatgccaat 3720 atcagttggg aatatgaggg accagagcat gtgaactttt atgttgaata tggtgtagca 3780 ggcagcaaag aagaatggag aaaagaaatt gtaaatggtt ctcggagctt ctttgggtta 3840 aagggtctaa tgccaggaac agcatacaaa gttcgagttg gtgctgtggg ggactctggt 3900 tttgtgagtt cagaggatgt gtttgagaca ggcccagcga tggcaagccg gcaggtggat 3960 attgcaactc agggctggtt cattggtctg atgtgtgctg ttgctctcct tatcttaatt 4020 ttgctgattg tttgcttcat cagaagaaac aagggtggta aatatccagt taaagaaaag 4080 gaagatgccc atgctgaccc tgaaatccag cctatgaagg aagatgatgg gacatttgga 4140 gaatacagtg atgcagaaga ccacaagcct ttgaaaaaag gaagtcgaac tccttcagac 4200 aggactgtga aaaaagaaga tagtgacgac agcctagttg actatggaga aggggttaat 4260 ggccagttca atgaggatgg ctcctttatt ggacaataca gtggtaagaa agagaaagag 4320 ccggctgaag gaaacgaaag ctcagaggca ccttctcctg tcaacgccat gaattccttt 4380 gtttaatttt taagctcttt gccaatattc catttctcta gaatgtttat cctaagcact 4440 tgtttgtcag ccctctcata ctatgaacat atgggtagag agtatatttt ctgctgtatg 4500 ttagtattat gagaatagtt acagcaaaaa cataactcag tcaaatgata tgttaatatg 4560 aactggaatg caaagtgcat actttttcat tcaaaatggg tattcttgat ttcctcagaa 4620 ctgataaaaa ataatgcaac atcaccaaca gatcctgtta tttcctctgc aggatacagt 4680 tcaatatgat gcatgaaaaa tgctccacat ttaaaggaca tacccgtgta tgttatgaaa 4740 acatggtttg atactttgtt tatactaccc tcagctgaac ccctatatat gaattccgtt 4800 ttcattgtca agaatgttac tgtagtattc tctagaactt caatgtcttt gtggacattg 4860 ttgtgaaatt ggtgactatg tatagctgtc gttagtcttt ttgggagact gttaggaaca 4920 gtttgtacag tatatacttg ctaaatgagt tcattatgac agtcacattg ctgatgctta 4980 ctgagaacta ttacctactc ttggctcctg ttactccgta ggcttcttaa tcttccaggc 5040 attacagcag cacagtgttc tactttttac atcatttcta tgttcggttg tttttaggca 5100 taaacaatgt gtattgcagt gcatttcggc atttgtgcca tactgaaaga atcaaaaaca 5160 aatcatccaa attaaatttc aaacattatt tcagagaaca cagggcaaga cacatacagt 5220 gccttcagat attaagcatt ccacaacatc gtgcattctg tatcagctgg tccagtccat 5280 tctgggtcct agattactgt cattgtctaa aagtaacttt taaaaagcag agttcatgaa 5340 aactgcaatg ctgggaaaag aaggaaacat gaaaataaaa ataagacagt ttattagaaa 5400 tagcatttcc tcataagcat aaaaagaaaa tctttgttgc caactgaagc acatgatgat 5460 tttgtggtcc tttatggttt ctattacatt cagtaagaaa gatgtcaaca tgctagaaaa 5520 ttaattttaa aactaagtta ttccaacact aaaagcatac aacagcatgc caacagtaat 5580 atattattct ccaagacttt acctatgtaa gtgttcaaaa ctctgcagca ttaaacaacg 5640 tgtatgcaaa ttgttatgga tacatttcag aatctaagaa atcaggcaag tgcttaaaag 5700 gccaacggtc caagggatta catctgcagt ttaaaaagta aatatatatt ctatcgtatt 5760 cataaacaat atctatcaaa tgggttacct ccaaatatga aaatctataa caacctatgg 5820 ttgaaggaat gctcagtttc atttgccaat aaattggttt ctcataactt gcatcaagtt 5880 taattttaag taaagctttt tatatgtaga tattttgttg aatttgtaaa tacacttaaa 5940 atgtagatgc tatatgctta taggtgttac atacaaataa acatgcaatg tttatgttgt 6000 actgtataag aggtaagcta attaatgcag tgaatgggat tggaaagcat ctacttaaat 6060 atctattggg ttcccccctc cccccacctt ttttgctgtg aaactgaaat agtgaacttt 6120 tctacgtatt gacagcagat ttttcgatga aatcttcaga gctttgccta tggggcacag 6180 taggcctagt aacctggcat gtttgatata tgtaggtaaa gcataattta aagtaatccc 6240 aggtaaagat ggccctaaat actttcatgt ctctatattc atttttcaca gatccacctg 6300 tctcttgaaa atataaaaag acaaaacagg tttgccttgg catcagagag cacaaagatt 6360 aaaagttact ttaaatttgc caatattttg ggagaacaat aaaactacat tttttcctct 6420 tccatactgg tagatgcgaa atttatctgt gcatgaaagg gtcacttctg taatagtgca 6480 acagatttgg tattaaaaat taaatgtggt tttaaaagtt cctctctctt ttgtaattta 6540 tgttcccaat tgagtgtgaa tgtccaagta atggtgtatg taatggtaca ggcaaatgtg 6600 actggatttc cctcaaaaaa gtaactatta aacagtcttg atctctttgt gacttttaa 6659 <210> 37 <211> 2821 <212> DNA <213> Homo sapiens <400> 37 gaaaccgttt ctacatggct ggctctaagc cagatgatat ttcatagtgc aaagagggat 60 agaacctcac tggtggccaa atgtgattat atgctataac cctgtgcccc tactctgaca 120 cccaccccca agcagttacc ctctgttgga agcctgcagc tttctttgtt tgtttcttta 180 attatacaga cagtaggatc tgcatcctta ctagcatata gaaaaatcag agaaacaatg 240 caaccaagag tgctgttttc atttgtttct tctgcatcct tttaatggaa ttttgtaggt 300 ctcttgaaag tgatgcagaa gaccacaagc ctttgaaaaa aggaagtcga actccttcag 360 acaggactgt gaaaaaagaa gatagtgacg acagcctagt tgactatgga gaaggggtta 420 atggccagtt caatgaggat ggctccttta ttggacaata cagtggtaag aaagagaaag 480 agccggctga aggaaacgaa agctcagagg caccttctcc tgtcaacgcc atgaattcct 540 ttgtttaatt tttaagctct ttgccaatat tccatttctc tagaatgttt atcctaagca 600 cttgtttgtc agccctctca tactatgaac atatgggtag agagtatatt ttctgctgta 660 tgttagtatt atgagaatag ttacagcaaa aacataactc agtcaaatga tatgttaata 720 tgaactggaa tgcaaagtgc atactttttc attcaaaatg ggtattcttg atttcctcag 780 aactgataaa aaataatgca acatcaccaa cagatcctgt tatttcctct gcaggataca 840 gttcaatatg atgcatgaaa aatgctccac atttaaagga catacccgtg tatgttatga 900 aaacatggtt tgatactttg tttatactac cctcagctga acccctatat atgaattccg 960 ttttcattgt caagaatgtt actgtagtat tctctagaac ttcaatgtct ttgtggacat 1020 tgttgtgaaa ttggtgacta tgtatagctg tcgttagtct ttttgggaga ctgttaggaa 1080 cagtttgtac agtatatact tgctaaatga gttcattatg acagtcacat tgctgatgct 1140 tactgagaac tattacctac tcttggctcc tgttactccg taggcttctt aatcttccag 1200 gcattacagc agcacagtgt tctacttttt acatcatttc tatgttcggt tgtttttagg 1260 cataaacaat gtgtattgca gtgcatttcg gcatttgtgc catactgaaa gaatcaaaaa 1320 caaatcatcc aaattaaatt tcaaacatta tttcagagaa cacagggcaa gacacataca 1380 gtgccttcag atattaagca ttccacaaca tcgtgcattc tgtatcagct ggtccagtcc 1440 attctgggtc ctagattact gtcattgtct aaaagtaact tttaaaaagc agagttcatg 1500 aaaactgcaa tgctgggaaa agaaggaaac atgaaaataa aaataagaca gtttattaga 1560 aatagcattt cctcataagc ataaaaagaa aatctttgtt gccaactgaa gcacatgatg 1620 attttgtggt cctttatggt ttctattaca ttcagtaaga aagatgtcaa catgctagaa 1680 aattaatttt aaaactaagt tattccaaca ctaaaagcat acaacagcat gccaacagta 1740 atatattatt ctccaagact ttacctatgt aagtgttcaa aactctgcag cattaaacaa 1800 cgtgtatgca aattgttatg gatacatttc agaatctaag aaatcaggca agtgcttaaa 1860 aggccaacgg tccaagggat tacatctgca gtttaaaaag taaatatata ttctatcgta 1920 ttcataaaca atatctatca aatgggttac ctccaaatat gaaaatctat aacaacctat 1980 ggttgaagga atgctcagtt tcatttgcca ataaattggt ttctcataac ttgcatcaag 2040 tttaatttta agtaaagctt tttatatgta gatattttgt tgaatttgta aatacactta 2100 aaatgtagat gctatatgct tataggtgtt acatacaaat aaacatgcaa tgtttatgtt 2160 gtactgtata agaggtaagc taattaatgc agtgaatggg attggaaagc atctacttaa 2220 atatctattg ggttcccccc tccccccacc ttttttgctg tgaaactgaa atagtgaact 2280 tttctacgta ttgacagcag atttttcgat gaaatcttca gagctttgcc tatggggcac 2340 agtaggccta gtaacctggc atgtttgata tatgtaggta aagcataatt taaagtaatc 2400 ccaggtaaag atggccctaa atactttcat gtctctatat tcatttttca cagatccacc 2460 tgtctcttga aaatataaaa agacaaaaca ggtttgcctt ggcatcagag agcacaaaga 2520 ttaaaagtta ctttaaattt gccaatattt tgggagaaca ataaaactac attttttcct 2580 cttccatact ggtagatgcg aaatttatct gtgcatgaaa gggtcacttc tgtaatagtg 2640 caacagattt ggtattaaaa attaaatgtg gttttaaaag ttcctctctc ttttgtaatt 2700 tatgttccca attgagtgtg aatgtccaag taatggtgta tgtaatggta caggcaaatg 2760 tgactggatt tccctcaaaa aagtaactat taaacagtct tgatctcttt gtgactttta 2820 a 2821 <210> 38 <211> 6296 <212> DNA <213> Homo sapiens <400> 38 cgcgcgggcg cgggggacgg cgcaggggcc gcctggctgg agcagccaga ggggatagct 60 tcgtcgagaa cggaggacac cggcggtcca gggtcctggg cagtcgcgcc agagctgagc 120 ggagggcgcg gcgcgagaac gaatctttgt gacattctct ctcagcattc tttatcccct 180 gtttgctgaa gacttcgaca aaagctggtc ttagctgttg gcattctcct gagaaaagga 240 tagcttcaga aatcagaaaa acatttggga ggtgtctagc ccagtggacc ttctgaagag 300 caatgctaag aagacgtttg gtttaaagaa ttaaaaggaa gaacaactta agagcttctt 360 caaagtttcc cgcatgaaaa ttacttaaac gttgcacaca acgtttcaca aaatcttttg 420 tgaaagaaga aaaggaaatt cagtgtgtga gtctcagcag gagttaagct aatgcagctt 480 aaaataatgc cgaaaaagaa gcgcttatct gcgggcagag tgcccctgat tctcttcctg 540 tgccagatga ttagtgcact ggaagtacct cttgatctgg tacagcctcc aaccatcacc 600 caacagtctc caaaagatta cattattgac cctcgggaga atattgtaat ccagtgtgaa 660 gccaaaggga aaccgccccc aagcttttcc tggacccgta atgggactca ttttgacatc 720 gataaagacc ctctggtcac catgaagcct ggcacaggaa cgctcataat taacatcatg 780 agcgaaggga aagctgagac ctatgaagga gtctatcagt gtacagcaag gaacgaacgc 840 ggagctgcag tttctaataa cattgttgtc cgcccatcca gatcaccatt gtggaccaaa 900 gaaaaacttg aaccaatcac acttcaaagt ggtcagtctt tagtacttcc ctgcagaccc 960 ccaattggat taccaccacc tataatattt tggatggata attcctttca aagacttcca 1020 caaagtgaga gagtttctca aggtttgaat ggggaccttt atttttccaa tgtcctccca 1080 gaggacaccc gcgaagacta tatctgttat gctagattta atcatactca aaccatacag 1140 cagaagcaac ctatttctgt gaaggtgatt tcagtggatg aattgaatga cactatagct 1200 gctaatttga gtgacactga gttttatggt gctaaatcaa gtagagagag gccaccaaca 1260 tttttaactc cagaaggcaa tgcaagtaac aaagaggaat taagaggaaa tgtgctttca 1320 ctggagtgca ttgcagaagg actgcctacc ccaattattt actgggcaaa ggaagatgga 1380 atgctaccca aaaacaggac agtttataag aactttgaga aaaccttgca gatcattcat 1440 gtttcagaag cagactctgg aaattaccaa tgtatagcaa aaaacgcatt aggagccatc 1500 caccatacca tttctgttag agttaaagcg gctccatact ggatcacagc ccctcaaaat 1560 cttgtgctgt ccccaggaga ggatgggacc ttgatctgca gagctaatgg caaccccaaa 1620 cccagaatta gctggttaac aaatggagtc ccaatagaaa ttgcccctga tgaccccagc 1680 agaaaaatag atggcgatac cattattttt tcaaatgttc aagaaagatc aagtgcagtc 1740 tatcagtgca atgcctctaa tgaatatgga tatttactgg caaacgcatt tgtaaatgtg 1800 ctggctgagc caccacgaat cctcacacct gcaaacacac tctaccaggt cattgcaaac 1860 aggcctgctt tactagactg tgccttcttt gggtctcctc tcccaaccat cgagtggttt 1920 aaaggagcta aaggaagtgc tcttcatgaa gatatttatg ttttacatga aaatggaact 1980 ttggaaattc ctgtggccca aaaggacagt acaggaactt atacgtgtgt tgcaaggaat 2040 aaattaggga tggcgaagaa tgaagttcac ttagaaatca aagatcctac atggatcgtt 2100 aaacagcccg aatatgcagt tgtgcaaaga gggagcatgg tgtcctttga atgcaaagtg 2160 aaacatgatc acaccttatc cctcactgtc ctgtggctga aggacaacag ggaactgccc 2220 agtgatgaaa ggttcactgt tgacaaggat catctagtgg tagctgatgt cagtgacgat 2280 gacagcggga cctacacgtg tgtggccaac accactctgg acagcgtctc cgccagcgct 2340 gtgcttagcg ttgttgatgt cccaaatcct ccctttgact tagaactgac agatcaactt 2400 gacaaaagtg ttcagctgtc atggacccca ggcgatgaca acaatagccc cattacaaaa 2460 ttcatcatcg aatatgaaga tgcaatgcac aagccagggc tgtggcacca ccaaactgaa 2520 gtttctggaa cacagaccac agcccagctg aagctgtctc cttacgtgaa ctactccttc 2580 cgcgtgatgg cagtgaacag cattgggaag agcttgccca gcgaggcgtc tgagcagtat 2640 ttgacgaaag cctcagaacc agataaaaac cccacagctg tggaaggact gggatcagag 2700 cctgataatt tggtgattac gtggaagccc ttgaatggtt tcgaatctaa tgggccaggc 2760 cttcagtaca aagttagctg gcgccagaaa gatggtgatg atgaatggac atctgtggtt 2820 gtggcaaatg tatccaaata tattgtctca ggcacgccaa cctttgttcc atacctgatc 2880 aaagttcagg ccctgaatga catggggttt gcccccgagc cagctgtagt catgggacat 2940 tctggagaag acctcccaat ggtggctcct gggaacgtgc gtgtgaatgt ggtgaacagt 3000 accttagccg aggtgcactg ggacccagta cctctgaaaa gcatccgagg acacctacaa 3060 ggctatcgga tttactattg gaagacccag agttcatcta aaagaaacag acgtcacatt 3120 gagaaaaaga tcctcacctt ccaaggcagc aagactcatg gcatgttgcc ggggctagag 3180 ccctttagcc actacacact gaatgtccga gtggtcaatg ggaaagggga gggcccagcc 3240 agccctgaca gagtctttaa tactccagaa ggagtcccca gtgctccctc gtctttgaag 3300 attgtgaatc caacactgga ctctctcact ttggaatggg atccaccgag ccacccgaat 3360 ggcattttga cagagtacac cttaaagtat cagccaatta acagcacaca tgaattaggc 3420 cctctggtag atttgaaaat tcctgccaac aagacacggt ggactttaaa aaatttaaat 3480 ttcagcactc gatataagtt ttatttctat gcacaaacat cagcaggatc aggaagtcaa 3540 attacagagg aagcagtaac aactgtggat gaagcgatgg caagccggca ggtggatatt 3600 gcaactcagg gctggttcat tggtctgatg tgtgctgttg ctctccttat cttaattttg 3660 ctgattgttt gcttcatcag aagaaacaag ggtggtaaat atccagttaa agaaaaggaa 3720 gatgcccatg ctgaccctga aatccagcct atgaaggaag atgatgggac atttggagaa 3780 tacagtgatg cagaagacca caagcctttg aaaaaaggaa gtcgaactcc ttcagacagg 3840 actgtgaaaa aagaagatag tgacgacagc ctagttgact atggagaagg ggttaatggc 3900 cagttcaatg aggatggctc ctttattgga caatacagtg gtaagaaaga gaaagagccg 3960 gctgaaggaa acgaaagctc agaggcacct tctcctgtca acgccatgaa ttcctttgtt 4020 taatttttaa gctctttgcc aatattccat ttctctagaa tgtttatcct aagcacttgt 4080 ttgtcagccc tctcatacta tgaacatatg ggtagagagt atattttctg ctgtatgtta 4140 gtattatgag aatagttaca gcaaaaacat aactcagtca aatgatatgt taatatgaac 4200 tggaatgcaa agtgcatact ttttcattca aaatgggtat tcttgatttc ctcagaactg 4260 ataaaaaata atgcaacatc accaacagat cctgttattt cctctgcagg atacagttca 4320 atatgatgca tgaaaaatgc tccacattta aaggacatac ccgtgtatgt tatgaaaaca 4380 tggtttgata ctttgtttat actaccctca gctgaacccc tatatatgaa ttccgttttc 4440 attgtcaaga atgttactgt agtattctct agaacttcaa tgtctttgtg gacattgttg 4500 tgaaattggt gactatgtat agctgtcgtt agtctttttg ggagactgtt aggaacagtt 4560 tgtacagtat atacttgcta aatgagttca ttatgacagt cacattgctg atgcttactg 4620 agaactatta cctactcttg gctcctgtta ctccgtaggc ttcttaatct tccaggcatt 4680 acagcagcac agtgttctac tttttacatc atttctatgt tcggttgttt ttaggcataa 4740 acaatgtgta ttgcagtgca tttcggcatt tgtgccatac tgaaagaatc aaaaacaaat 4800 catccaaatt aaatttcaaa cattatttca gagaacacag ggcaagacac atacagtgcc 4860 ttcagatatt aagcattcca caacatcgtg cattctgtat cagctggtcc agtccattct 4920 gggtcctaga ttactgtcat tgtctaaaag taacttttaa aaagcagagt tcatgaaaac 4980 tgcaatgctg ggaaaagaag gaaacatgaa aataaaaata agacagttta ttagaaatag 5040 catttcctca taagcataaa aagaaaatct ttgttgccaa ctgaagcaca tgatgatttt 5100 gtggtccttt atggtttcta ttacattcag taagaaagat gtcaacatgc tagaaaatta 5160 attttaaaac taagttattc caacactaaa agcatacaac agcatgccaa cagtaatata 5220 ttattctcca agactttacc tatgtaagtg ttcaaaactc tgcagcatta aacaacgtgt 5280 atgcaaattg ttatggatac atttcagaat ctaagaaatc aggcaagtgc ttaaaaggcc 5340 aacggtccaa gggattacat ctgcagttta aaaagtaaat atatattcta tcgtattcat 5400 aaacaatatc tatcaaatgg gttacctcca aatatgaaaa tctataacaa cctatggttg 5460 aaggaatgct cagtttcatt tgccaataaa ttggtttctc ataacttgca tcaagtttaa 5520 ttttaagtaa agctttttat atgtagatat tttgttgaat ttgtaaatac acttaaaatg 5580 tagatgctat atgcttatag gtgttacata caaataaaca tgcaatgttt atgttgtact 5640 gtataagagg taagctaatt aatgcagtga atgggattgg aaagcatcta cttaaatatc 5700 tattgggttc ccccctcccc ccaccttttt tgctgtgaaa ctgaaatagt gaacttttct 5760 acgtattgac agcagatttt tcgatgaaat cttcagagct ttgcctatgg ggcacagtag 5820 gcctagtaac ctggcatgtt tgatatatgt aggtaaagca taatttaaag taatcccagg 5880 taaagatggc cctaaatact ttcatgtctc tatattcatt tttcacagat ccacctgtct 5940 cttgaaaata taaaaagaca aaacaggttt gccttggcat cagagagcac aaagattaaa 6000 agttacttta aatttgccaa tattttggga gaacaataaa actacatttt ttcctcttcc 6060 atactggtag atgcgaaatt tatctgtgca tgaaagggtc acttctgtaa tagtgcaaca 6120 gatttggtat taaaaattaa atgtggtttt aaaagttcct ctctcttttg taatttatgt 6180 tcccaattga gtgtgaatgt ccaagtaatg gtgtatgtaa tggtacaggc aaatgtgact 6240 ggatttccct caaaaaagta actattaaac agtcttgatc tctttgtgac ttttaa 6296 <210> 39 <211> 2581 <212> DNA <213> Homo sapiens <400> 39 agcgcctgcg cactgcgccg ccggctgggg tgctgggggc ggggcagggg caggtgtagc 60 ctctgtgcct cgttgtcccc tggcgctacc cggacatctc tcagggtgcc ggcaccatga 120 agatctggac ttcggagcac gtctttgacc acccgtggga aactgttaca acagctgcaa 180 tgcagaaata cccaaaccct atgaacccaa gtgtggttgg agttgatgtg ttggacagac 240 atatagatcc ctctggaaag ttgcacagcc acagacttct cagcacagag tggggactgc 300 cttccattgt gaagtctctt attggtgcag caagaacgaa aacatatgtg caagaacatt 360 ctgtagttga tcctgtagag aaaacaatgg aacttaaatc tactaatatt tcatttacaa 420 acatggtttc agtagatgag agacttatat acaaaccaca tcctcaggat ccagaaaaaa 480 ctgttttgac acaagaagcc ataattaccg tgaaaggagt tagcctcagc agttaccttg 540 aaggactgat ggcaagtacg atatcctcaa atgctagtaa aggccgagaa gcaatggaat 600 gggtaataca taaattaaat gctgagattg aagaactgac agcctcagca agaggaacca 660 taaggactcc aatggcagca gcagcgtttg cagagaagtg atcgtgacag ttggtagaca 720 acatcgggta ctccaggtct ctccaaactg actatatatt tatttgttat tttaaaaata 780 caactatatt ttgggtagtt tttttttttt tttttttgat aagttggtgt aaggctatgt 840 gacttgatca aaacagatgc agggcctcta aataaaaggg atcatctgaa attaatgttg 900 tttgaaatta ctatctgatt ttgagggttc cagtatttct gtgaaaattc aacaagaact 960 ccttggaaac tggtattgat attcagtctc cttaaggtag atttttcaag cttttcatac 1020 attggaactc cacctgactt tggaccaacc ccagaacaga gcagagccac ctcctataga 1080 cgcccattgc cctgctgctg tacacttcag cagcttgcac aagggagctc acttaaaagg 1140 agaaattgtg tagttttaaa atatattttg tgtaaaatac cttactatgc tataaaccac 1200 cattaaaaac cagtgttttg atttggtact taaatatttt tggagtgaaa attatcacta 1260 aagtaacatg actccaacaa aagtatggtt tcattataaa agagtactgt attgatttgc 1320 ccaagttttg taacttagta aaggtattaa cttccttgga tttgtacttt gtgatttagt 1380 atgctgtatc gtgggctggt tatgttaact gaaaaaaata aagtcattac ctgagttttg 1440 cagtgctcta acttaaacag aagaacagct gttcacatct tttagcattt tacatttgcc 1500 taacttaaaa attgccatgt gtcaaaatca tggttttgta attgctaagg catgatatgt 1560 caggttattt gaatataatt actttttgaa gtaattgtga ccacaaaaca tcttttttac 1620 atgaaggagc tgtgtatcat ttgaaattac tcaaatgatg tcttgctctg aggcataaat 1680 cccaggtact tagtgttttt aataatatgg tgccactgca ggatttgggg gcggtgggga 1740 agaacaagca taatggtagg gggaggcttg gcctgaaact aaccactgag tgaattgcac 1800 tgcaggtttt acttaacggg aattccttat ttgggatgtc aagagggcag ctgcaaactg 1860 aaaaacaatc cagtaaatgt actttgtttt atgtattgta gcaggcaatt aactactaaa 1920 taatagcttt gacatttgca attgttgcat agagactatt tttgctagaa gatgattagc 1980 tcttgccttt attttacagt gcttagtgtg ataaacttct agtcatgttt cctatccaag 2040 agaccagtta atatatgtac ataaaccaca gaaatagtat aacacactat ttttaaatta 2100 tcgttttcct acttaaattt tgtttagctt aagacttctt aggacatttg taaaagcagg 2160 ttaaatttaa taaggtttct gatttttttt tgtaaccgga gatagttttt acaagtgaaa 2220 taacatttca gctaaataaa acatcgctaa ataattgata tttgatgaaa atctgctttg 2280 tataatttct gtaaattatc cttgttctga aaaaggtgta atgccctaat atttttaaat 2340 ccttatcctt tgatttttta aaaactgacc tattgataaa actataaatt ttcattttcc 2400 agtgcagtta gttacctttt taaacataaa tgcacaacaa gcaaatgaat ttaagagaac 2460 taaactggaa taagtgttca taaatgaaac ccttggacta tttaataaag ttgaaatgtg 2520 aattaaggaa aacttttgtt aataaaaact ttcttttaag tgaaaaaaaa aaaaaaaaaa 2580 a 2581 <210> 40 <211> 2150 <212> DNA <213> Homo sapiens <400> 40 agctccggcc ccgaccggaa gccccaccgc accgtcaggg acgcggactc gggagtgcgc 60 acattcgcag cccgggcagc cctgctgcgc accgggcctc gcgccccgcg ccccgcgccc 120 cgcgccccgc gccccgcacc ggcctccagg atcatgtggt atgtcagcac caggggcgta 180 gccccacggg tcaactttga gggggccctc ttctctggct atgcacctga cgggggcctc 240 tttatgcctg aagagctccc acagttggac agagggaccc tgtgccagtg gagcacactc 300 tcctatcctg gcctggtgaa ggagctgtgt gccctcttca ttggctctga gctccttcca 360 aaagatgaat taaatgatct gatcgaccga gccttcagca gattccgtca cagagaagtg 420 gtccatctgt ccaggttgag gaatgggctg aacgtgttgg agctgtggca tggcgtcaca 480 tatgcattta aggacctgtc cctgtcctgc acaacacagt tcctgcagta cttcctggag 540 aagagggaga agcacgtcac tgtggttgta ggaacatctg gggacacagg aagtgctgcc 600 attgagagtg ttcaaggggc aaagaacatg gacattatcg ttctgctgcc caaaggtcac 660 tgcacaaaga ttcaggagct ccagatgaca acggtgctga agcagaacgt acatgtgttt 720 ggagtggagg gaaacagcga tgagctcgat gagccgatca agactgtgtt tgccgatgtg 780 gcttttgtca agaagcacaa tctgatgagc ctgaattcga tcaactggtc ccgggtcctg 840 gtgcagatgg cccatcactt ctttgcttac ttccagtgta cgccatcctt ggacacacat 900 cccctacccc tggtggaggt ggttgtgcca acaggggctg ccggtaacct tgcagctggg 960 tacattgctc aaaagatagg cctgcccatc cgtctggtcg tggcagtgaa ccgcaatgac 1020 atcatccaca ggactgtcca gcagggagac ttctctctct ctgaggctgt taaatcaacc 1080 ttggcatcag ctatggacat tcaggtgccc tacaacatgg agagggtgtt ctggctgctc 1140 tctggctctg acagccaggt gacaagagcc ctcatggagc agtttgaaag gacccaaagt 1200 gtgaatctgc ccaaggaact gcacagcaag ctttcagagg cagtgacatc cgtgtcagtg 1260 tcggatgaag ccatcaccca gaccatgggc cgctgctggg atgagaacca gtacttgctg 1320 tgcccccact cagcggtggc cgtgaactac cattaccagc agatagacag gcagcagccc 1380 agcactcccc ggtgctgcct cgcccctgcc tctgcagcca agttcccgga agctgtcctg 1440 gctgctggcc tgacccctga gactcccgcg gagatcgtag ccctggagca caaggagaca 1500 cgctgcaccc tgatgcggag aggtgacaac tggatgctga tgcttcggga caccattgag 1560 gaccttagcc gacagtggag gagtcatgcc ctcaacacct cccagtagcc tggctggagg 1620 tggctttctt taggcttcag atcccaggaa gatgcacctt ctgagctgcc ttgtgcaccc 1680 tccccattaa gcgtaggtta ggaggtttcc gggaggctgc tcagctggat ctggagccag 1740 ctggctttgc tccgttccct ggctagtctg tgcctggtca ccagggaggc tgagtgaggg 1800 gctgtgaaca gttgccggaa gcaccccctc cctccccggc ccgtgcagca gtgtctgagc 1860 tgtagtgaaa gtttcagggc ctgcaaaaga agaggcttgg gcacaggact gaccatggct 1920 ccaggggttt aggaccccag acctgtgaag gtgggagcag ctcaccacct tcacgcaggc 1980 tttgtatgtt ctctgagcct tagttgattt tggcccccaa accaaatcca aaggttctgg 2040 cccaccttgt cagaggcttc caccctgctc acatgttggg aatccctgga ataaaatgct 2100 tgttcagtgt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150 <210> 41 <211> 2368 <212> DNA <213> Homo sapiens <400> 41 agccgccaca ctttcccaag cccgcaggcg ccccccccaa caccagcgct gcacccccga 60 cccattcccc gcggccccct ccaggagaaa aaatgaaacc agactggccg aggagggggg 120 cggcagggac cagggtgcgg agcagaggtg agggagacgg gacttacttt gcgaggcgcg 180 gtgcagggcg ccgccgacga gaaataaagg ccccgatacg ggctgcctgg agccccccga 240 gcgcagcaat gtcagggctc cagtccgggc ggcgttggcg gccgcagggg acggggacgg 300 gcgcgcgtgc ggcgggcgct ctcgctgcgc tccggctcgg gccccggctc cgcgcggctc 360 cgctcctggc tcccctctgg ctcctggcac caactccgga cagtcacatg acgccggcgc 420 cgctcgctct gcgagcctcc cggggctggc gggagaataa cttgtctgac taccagtatt 480 cttggatgca gaagtgctga agatgagcac acacacgtac ggagaatttc tggagaattc 540 agctgctcag aacaagaact gagatccaga gagatgatga ctttgcccat agaccaaaca 600 aagaaataca tgtttcagtc ctgtgtcctc ctgctatgtg tgtccggaat tggtgggttc 660 ttggtctcac tgactccaag aatgaagctg cggaccctcg cggaccgtgt gtgaatgcct 720 gctctgtgag ccctcagaat ctactggctg aatgagtgcg tggaggaaat gtgctcagag 780 ctgctgtgtg tcatcctgtg tttgaagtgc tcctgcagct atcattcatc cagttaagaa 840 tttgaagaag tgtgtgcaca aagacggagt ctcactctgt tgcccaggct ggagtgcagt 900 ggcacaatct cggctcactg caacctctac ctcctggatt caagcggttt tcctgcctca 960 gcctccagag taacagggat tacaggcata ctccaccttg ccctgctgat tttgtatttt 1020 tagtagagac aagagtttca ccatgttggc caggctggtc ttgaactcct gacctcaagt 1080 gatccactgc ctcagcctcc caaagtgctg ggattatagg cgtgagccac tgcgcctggc 1140 caaatgctct actttttaat caatgttttc caaaataggg atttttgcta tgtgctttag 1200 aaattagaga acaaacggtg ataatatatg ctaaacttaa aattagtatg cctcctttta 1260 tagacaacaa gaactttgtc acttcccagt ttgtcttgtc attcaggagg ctcagagcta 1320 cgatctgtgc ccactcgtgc tgcctcttct taactttgat ttcctgaagc agcgatttca 1380 tctccgtttc ccctcatcac ctgttctttt aactgtttaa aaacagcatt acatgttgtt 1440 gcaagtggcc tcaaattctt tttggtagaa gggaaattgt aatccatgag aagaaaaaaa 1500 ttttcctaac tattctcagg tgtgtttaag ggctgcattc catgatgcta tcagtgcctt 1560 ctttcagctc acaggatatc ggccatgtta atgagtctga tgttgctagt atcacaggca 1620 ccggaaaata tgcacattat gctggagcat tagaatgcaa cagaaagagc cctgggcttg 1680 gagtatgcag aactggttct tgttacaact cctcttacta gtgggctctg gaagaaaaca 1740 cattgaattc atgatcatgg ttaacctttg gagagagaga ggagaccagg atgaaggagc 1800 cagtcgaaga tcctgttcaa gtgtacactg agccagcagg ttcaccagaa agctattgag 1860 cgtttgctgg aacacattat gcagggtgaa tttcttctgg aatgttgcca aggatttttt 1920 atgcttctgt ggcaggcatt tcttgaacat tgtcatttag ccaagcaaag aagattttct 1980 taaaggatag aaagtgttta aaaatttttg tttgtttgaa gataggttaa atggctatat 2040 gatctcagga taagacagag aaaatcactt atttctctaa gtgatctgat taggttagtg 2100 atgttttgcc tttaaacaga ttcatcatta ttcctaaagt attgctgtat taatactgtc 2160 ttctagaaag tatccaccag tgcctacttt tcttcgatat cattagctgt ttttcgaaac 2220 tgaatttgct cttcagagat ttctcatatg tttgcgtata aggaactact ggtaatagcc 2280 aagaaaattt ggaggtgcag agaacatgct gaaacagaat ttttcacttt caattctaga 2340 actatgccat aaaaaaaaag gaaaatgt 2368 <210> 42 <211> 1928 <212> DNA <213> Homo sapiens <400> 42 cctgcctcag cctccagagt aacagggatt acaggcatac tccaccttgc cctgctgatt 60 ttgtattttt agtagagaca agagtttcac catgttggcc aggctggtct tgaactcctg 120 acctcaagtg atccactgcc tcagcctccc aaagtgctgg gattataggc gtgagccact 180 gcgcctggcc aaatgctcta ctttttaatc aatgttttcc aaaataggga tttttgctat 240 gtgctttaga aattagagaa caaacggtga taatatatgc taaacttaaa attagtatgc 300 ctccttttat agacaacaag aactttgtca cttcccagtt tgtcttgtca ttcaggaggc 360 tcagagctac gatctgtgcc cactcgtgct gcctcttctt aactttgatt tcctgaagca 420 gcgatttcat ctccgtttcc cctcatcacc tgttctttta actgtttaaa aacagcatta 480 catgttgttg caagtggcct caaattcttt ttggtagaag ggaaattgta atccatgaga 540 agaaaaaaat tttcctaact attctcaggt gtgtttaagg gctgcattcc atgatgctat 600 cagtgccttc tttcagctca caggatatcg gccatgttaa tgagtctgat gttgctagta 660 tcacaggcac cggaaaatat gcacattatg ctggagcatt agaatgcaac agaaagagcc 720 ctgggcttgg agtatgcaga actggttctt gttacaactc ctcttactag tgggctctgg 780 aagaaaacac attgaattca tgatcatggt taacctttgg agagagagag gagaccagga 840 tgaaggagcc agtcgaagat cctgttcaag tgtacactga gccagcaggt tcaccagaaa 900 gctattgagc gtttgctgga acacattatg cagggtgaat ttcttctgga atgttgccaa 960 ggatttttta tgcttctgtg gcaggcattt cttgaacatt gtcatttagc caagcaaaga 1020 agattttctt aaaggataga aaatgtttaa aaatttttgt ttgtttgaag ataggttaaa 1080 tggctatatg atctcaggat aagacagaga aaatcactta tttctctaag tgatctgatt 1140 aggttagtga tgttttgcct ttaaacagat tcatcattat tcctaaagta ttgctgtatt 1200 aatactgtct tctagaaagt atccaccagt gcctactttt cttcgatatc attagctgtt 1260 tttcgaaact gaatttgctc ttcagagatt tctcatatgt ttgcgtataa ggaactactg 1320 gtaatagcca agaaaatttg gaggtgcaga gaacatgctg aaacagaatt tttcactttc 1380 aattctagaa ctatgccata aaaaaaaagg aaaatgtaaa aatgtcttta tattagagca 1440 gatattttaa aagtattgca aattcaatga taaattctaa ggttaaaatt ggacacataa 1500 aaaatacaat atataaatat ctccccagaa attattatct aatgaatagt aaaagctgac 1560 tacaaaccat gtcattttaa caagggttta aatagtacca agattctcat catatgctct 1620 gggataccca gtgatgtaca agggttctct ctaaacatgg ggaggaaaaa tttcaaatat 1680 aaagatttga atcttgtctt tgccattcac tagctgtgtg atcttgggta agttacctgg 1740 tttctctgag cttcagtgtc atctgtaaaa caggaataat aatacctagc tcagaggcgg 1800 gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcacta 1860 ggtcaggagt ttgagaccag cctggccaag atggtgaaat cctgtctcta cttaaaaaaa 1920 aaaaaaaa 1928 <210> 43 <211> 1928 <212> DNA <213> Homo sapiens <400> 43 cctgcctcag cctccagagt aacagggatt acaggcatac tccaccttgc cctgctgatt 60 ttgtattttt agtagagaca agagtttcac catgttggcc aggctggtct tgaactcctg 120 acctcaagtg atccactgcc tcagcctccc aaagtgctgg gattataggc gtgagccact 180 gcgcctggcc aaatgctcta ctttttaatc aatgttttcc aaaataggga tttttgctat 240 gtgctttaga aattagagaa caaacggtga taatatatgc taaacttaaa attagtatgc 300 ctccttttat agacaacaag aactttgtca cttcccagtt tgtcttgtca ttcaggaggc 360 tcagagctac gatctgtgcc cactcgtgct gcctcttctt aactttgatt tcctgaagca 420 gcgatttcat ctccgtttcc cctcatcacc tgttctttta actgtttaaa aacagcatta 480 catgttgttg caagtggcct caaattcttt ttggtagaag ggaaattgta atccgtgaga 540 agaaaaaaat tttcctaact attctcaggt gtgtttaagg gctgcattcc atgatgctat 600 cagtgccttc tttcagctca caggatatcg gccatgttaa tgagtctgat gttgctagta 660 tcacaggcac cggaaaatat gcacattatg ctggagcatt agaatgcaac agaaagagcc 720 ctgggcttgg agtatgcaga actggttctt gttacaactc ctcttactag tgggctctgg 780 aagaaaacac attgaattca tgatcatggt taacctttgg agagagagag gagaccagga 840 tgaaggagcc agtcgaagat cctgttcaag tgtacactga gccagcaggt tcaccagaaa 900 gctattgagc gtttgctgga acacattatg cagggtgaat ttcttctgga atgttgccaa 960 ggatttttta tgcttctgtg gcaggcattt cttgaacatt gtcatttagc caagcaaaga 1020 agattttctt aaaggataga aaatgtttaa aaatttttgt ttgtttgaag ataggttaaa 1080 tggctatatg atctcaggat aagacagaga aaatcactta tttctctaag tgatctgatt 1140 aggttagtga tgttttgcct ttaaacagat tcatcattat tcctaaagta ttgctgtatt 1200 aatactgtct tctagaaagt atccaccagt gcctactttt cttcgatatc attagctgtt 1260 tttcgaaact gaatttgctc ttcagagatt tctcatatgt ttgcgtataa ggaactactg 1320 gtaatagcca agaaaatttg gaggtgcaga gaacatgctg aaacagaatt tttcactttc 1380 aattctagaa ctatgccata aaaaaaaagg aaaatgtaaa aatgtcttta tattagagca 1440 gatattttaa aagtattgca aattcaatga taaattctaa ggttaaaatt ggacacataa 1500 aaaatacaat atataaatat ctccccagaa attattatct aatgaatagt aaaagctgac 1560 tacaaaccat gtcattttaa caagggttta aatagtacca agattctcat catatgctct 1620 gggataccca gtgatgtaca agggttctct ctaaacatgg ggaggaaaaa tttcaaatat 1680 aaagatttga atcttgtctt tgccattcac tagctgtgtg atcttgggta agttacctgg 1740 tttctctgag cttcagtgtc atctgtaaaa caggaataat aatacctagc tcagaggcgg 1800 gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcacta 1860 ggtcaggagt ttgagaccag cctggccaag atggtgaaat cctgtctcta cttaaaaaaa 1920 aaaaaaaa 1928 <210> 44 <211> 2305 <212> DNA <213> Homo sapiens <400> 44 gcaaaagcgc tagggttgca agtggcacca gagacgtgcc cttgtcccgg ggtccatttg 60 agggtgagcg tgttggtgcc gagctgtttt tttgttttgt tttgttttgt tttgtttttg 120 agaccgaatc tcgttctgtc gcccaggctg gaatgcagtg gtgtgatctt ggctcactgc 180 aacctccacc ttccgggttc aagtgaatct cctgcctcag cctcctgagt agctgggatt 240 actggcaccc accaccacga ccagctaatt tttgtatttt tagtagagac gggttttcac 300 catgttggcc aggatggtct caatctcctg acctcaggcg atctgccttc ctcagcttcc 360 caaagtgctg ggattacagg tgtgagccac cgcacccggc cagtgctgag ctgttttgac 420 aacttggacc ccgggtcctc tgtgggtagg aaaatcagct ccctctttgc tcctctgggg 480 cagctgcacc tcgggccagc tttctgcctg tctgcctgcc ggcactgctg ggtcgctgta 540 cccaaacgca cagccggtgc cccgtgctag aaggtcttca gtttccagaa gagccaaagc 600 atctttggac ctacctaggg aaggacctgc ctgtgacctt tgccctgtcc tggagggtcc 660 agctttgggc tgaatggcag cacccacgct gggccgtctg gtgctgaccc acctgctggt 720 ggcccttttt ggcatgggct cctgggctgc tgtgaacggg atctgggtgg agctgcctgt 780 ggtggtaaaa gaccttccag agggttggag cctcccctca tacctctctg tggttgtggc 840 gctgggaaac ctgggtctgc tggtggtgac cctgtggagg cggctggccc cgggcaaggg 900 cgagcaggtc cccatccagg tggtacaggt gctgagtgta gtgggcacag ccctgctggc 960 ccctctgtgg caccacgtgg ccccagtggc agggcagctc cactctgtgg ccttcctaac 1020 tctggccttg gtgttggcaa tggcctgttg tacctctaat gtcactttcc tgcccttcct 1080 gagccacctg ccacctcctt tcttacggtc tttcttcctg ggtcagggtc tcagtgccct 1140 actcccctgt gtgctggccc tagtgcaagg tgtgggccgc ctcgagtgcc caccagcgcc 1200 caccaatggc acctctgggc ctcccctcga cttccctgag cgttttcctg ccagcacctt 1260 cttctgggca ctgactgccc ttctggtcac ttcagctgcc gccttccggg gtctcctgtt 1320 gctgttgcca tcactaccct ctgtaaccac agggggctca gggcctgaac ttcaactggg 1380 atccccagga gcagaggagg aagagaagga ggaagaagag gctttgccat tgcaggagcc 1440 accgagccag gcagcaggca ccatccctgg cccagaccct gaggtccatc agctgttctc 1500 agcccatggt gccttcctgc tgggcctgat ggccttcacc agtgccgtga ccaatggcgt 1560 gctgccttct gtgcagagct tttcctgttt gccctatggg cgcctggcct accacctggc 1620 tgtggtgctg ggcagtgccg ccaaccccct tgcctgcttc ctggccatgg gcgtgctgtg 1680 caggtccctg gcagggctgg ttggtctttc tctgctgggc atgctctttg gggcctacct 1740 gatggcactg gcaatcctga gcccctgccc acccctggtg ggcaccactg caggggtggt 1800 ccttgtggtg ctgtcgtggg tgctgtgtct gtgtgtgttc tcatatgtga aggtggctgc 1860 aagctccctg ctgcatggtg ggggtcggcc ggcattgctg gcagctggtg tggccatcca 1920 agtgggctcc ctgcttggtg ccggtgccat gttccctccc accagcatct accacgtgtt 1980 tcaaagcaga aaggactgtg tagacccctg tggcccctga gcctgggcag gtggggaccc 2040 aactccaccc cacctgtctt catcgtgagg ctgccacagt gcctgactac ttgtggccca 2100 ggcaggcttc ccccaacaca ggaacgctca tggacacctg cacactccac agaagacgtt 2160 ggcatgtgag gccagggtgg gcaccaaaga ccaggcccag agccagggga caggttgggg 2220 ctgtgggctt ggacccaggg cctgagacct ttgtgggatt tgtgcaataa agtgttttta 2280 tttaaaacca aaaaaaaaaa aaaaa 2305 <210> 45 <211> 4315 <212> DNA <213> Homo sapiens <400> 45 ggcggcggct ggcggcggcg gtggggcggg gcctgggctg tcagccggcc taggaggagg 60 aaggagcctg cggcgtgcag tgtgaggggc gggacccggc tgccggcggt gggtctagct 120 gggggaggtc gggccatgct ggtgggccag ggcgcggggc cgctggggcc cgcggtggtc 180 accgccgcgg tggtgctgct gctgagcggc gtggggccgg cgcacggctc ggaggacatc 240 gtggtgggct gcggtggctt cgtcaagtcg gacgtggaga tcaactactc tctcatcgag 300 ataaagctgt acaccaagca tgggactttg aaataccaga cagactgtgc ccctaataat 360 ggttacttta tgatcccttt gtatgataag ggggatttca ttctgaagat tgagcctccc 420 ctagggtgga gttttgagcc gacgaccgtg gagctccatg tggatggagt cagtgacatc 480 tgcacaaagg gtggggacat caactttgtc ttcactgggt tctctgtgaa tggcaaggtc 540 ctcagcaaag ggcagcccct gggtcctgcg ggagttcagg tgtctctgag aaacactggg 600 accgaagcaa agatccagtc cacagttaca cagcctggcg gaaagtttgc attttttaaa 660 gttctgcctg gagattatga aatcctcgca actcatccaa cctgggcgtt gaaagaggca 720 agcaccacag tgcgtgtaac caactccaat gccaatgcgg ccagtcccct catagttgct 780 ggctacaatg tgtctggctc tgtccgaagt gatggggagc ccatgaaagg cgtgaagttt 840 cttctctttt cttctttagt aactaaagag gatgtcctgg gctgcaatgt ctcaccagtg 900 cctgggttcc agccccaaga cgagagtctg gtgtatttgt gctacacggt ctccagagaa 960 gatggctcgt tctctttcta ttccttgcca agtgggggct acactgtgat tccgttctat 1020 cgaggggaga ggattacctt tgatgtggcg ccttccagac ttgacttcac agtggagcat 1080 gacagcttga aaatcgagcc cgtgttccac gtcatgggat tctccgtcac cgggagggtc 1140 ttgaacggac ccgaaggaga tggtgttcca gaagcagtag tcaccctgaa taaccaaatc 1200 aaagttaaaa caaaagctga tggctcattc cgccttgaga acataaccac agggacatac 1260 accatccatg ctcagaaaga gcacctctac tttgaaacgg tcaccatcaa aattgcacca 1320 aacacacctc agctggctga cattgttgca acagggttca gtgtctgtgg tcagatatca 1380 atcattcgct tccccgacac cgtcaagcag atgaataaat acaaagttgt cctgtcatct 1440 caagacaagg acaagtcttt ggtcaccgtg gagacagatg ctcatggatc attttgtttt 1500 aaagcaaacc cagggactta caaagtgcag gtgatggttc ctgaggcaga aaccagagca 1560 gggctgacgt tgaaacccca gacatttcct cttactgtga ccgacaggcc tgtgatggat 1620 gtggcctttg tacagttctt ggcatcagtt tctgggaaag tctcttgttt ggacacctgt 1680 ggtgacttgc tggtgactct acagtccctg agccgccagg gtgagaagcg gagcctccag 1740 ctctccggca aggtcaacgc catgactttc acctttgaca acgtgctccc tggaaaatac 1800 aaaataagca tcatgcatga ggattggtgc tggaagaaca agagcctgga ggtggaagtg 1860 ctggaggatg acgtgtctgc agttgagttc aggcagacgg gctacatgct gagatgttcc 1920 ctgtctcacg ccatcactct ggaattttat caggatggaa atgggcgtga gaatgtgggg 1980 atttataacc tctccaaagg agtcaaccga ttctgcctgt ccaagcctgg tgtgtacaaa 2040 gtgacccctc gctcctgcca ccggtttgag caagcgttct acacctatga cacgtcttca 2100 cctagtatct tgacattgac agccattcgc caccatgtcc ttggaactat caccaccgac 2160 aaaatgatgg atgtcactgt gactatcaag tcttccatcg acagtgaacc cgccttggtc 2220 ttaggccctc tgaagtctgt gcaggagctg cggagggagc agcagctggc tgagatcgag 2280 gcccgcaggc aggagaggga gaaaaacggc aatgaggaag gtgaagaaag aatgaccaag 2340 cctcctgtgc aggagatggt agatgagtta caaggcccct tctcgtatga tttctcttac 2400 tgggcgcggt ctggagagaa aatcactgtt acaccgtcat ctaaagagct gctcttttat 2460 cccccttcaa tggaagccgt tgtcagtgga gaaagctgcc cagggaagct gatcgagatc 2520 cacgggaagg caggcctgtt tttagaaggc cagatccacc ccgagttgga aggagtcgag 2580 attgtcatca gtgaaaaggg ggcaagttca ccgctgatca cagtctttac tgatgacaaa 2640 ggtgcctaca gtgttggccc cctgcacagt gacctggagt acacggtgac ctcacagaag 2700 gagggctatg ttctgactgc agtggaagga accatcggag acttcaaggc ctatgccctg 2760 gcaggcgtaa gctttgagat aaaagctgag gatgaccagc ccctcccggg agtcctctta 2820 tccctgagtg gtggcctgtt tcgttccaac ctcttgaccc aggacaacgg cattctgaca 2880 ttctcaaacc tgagccctgg ccagtattac ttcaaaccca tgatgaagga gttccggttt 2940 gagccatcct cacagatgat cgaggtgcag gaaggccaga acctgaagat caccatcacg 3000 gggtaccgaa ccgcttacag ttgctatggc acagtgtctt ccttaaacgg agagcccgaa 3060 caaggggttg ccatggaagc ggtgggccag aacgactgca gcatttacgg agaagacacc 3120 gtgacagacg aagagggcaa gttcagatta cgtggattgc tgccgggatg tgtgtaccac 3180 gttcagctca aggcagaagg caacgaccac attgagcggg cgctccccca ccatagggtg 3240 attgaggttg ggaataatga catcgatgat gtaaacatca tagttttccg gcagattaat 3300 caatttgatt taagtggaaa tgtgatcact tcctctgaat accttcctac gttatgggtc 3360 aagctttaca aaagcgaaaa cctcgacaat ccaatccaga cagtttccct tggccagtcc 3420 ctgttcttcc atttcccccc actgctcaga gatggcgaga actatgttgt gcttctggac 3480 tccacactcc ccagatccca gtatgactac atcttgcctc aagtttcttt caccgcagtg 3540 ggctaccata aacacatcac cttgattttt aatcccacga ggaagctgcc tgaacaggac 3600 atcgcacaag gatcctacat tgccctgcca ttgacgctgc tggttctgct ggccggttac 3660 aaccatgaca agctcattcc tttgctgctg cagttgacaa gccggctaca gggagtcggc 3720 gcgctcggcc aggcagcctc tgacaatagc ggcccagaag atgcaaagag acaagccaag 3780 aaacagaaga caaggcggac gtgaggagga aggggacagt tgcagtctca cttgggacag 3840 gccacagcca ggggtccggc cactacccgc ccgtgggata aaagccaaaa gcatgcgtca 3900 gctaacttca gcctgtgctg ctgggcccgc accccatgtc ccttgtcact gtggcatcct 3960 gcacccatcc tcacccctcc gtagagcccc tcgtgcaatg caatgaatgg accctcctgt 4020 cactctgctg aacagaattt attttctgag tcaaatataa tttattatta tttttgtcaa 4080 agaagtattt aagctgtgct gtggtgtgag aatgtcattc ttgatcttca gccttcgttt 4140 gcaagaagag ttccagttga tgtggtgttt ggttccatgg cggggtaccc tagggattca 4200 tctgttttct tcacttccct ttgcatctga gatcctgctg gaaaccacgg caacctgtat 4260 ccactattag gaggtaaaaa tcaataaaat ggcccattca tttgtgttgt agctc 4315 <210> 46 <211> 1124 <212> DNA <213> Homo sapiens <400> 46 ccagggcgcg acgcgctgcg gctcagcgac gcggcttcta gaaccgggtg attgaactaa 60 accttcgccg caccgagttt gcagtacggc cgtcacccgc accgctgcct gcttgcggtt 120 ggagaaatca aggccctacc gggcctccgt agtcacctct ctatagtggg cgtggccgag 180 gccggggtga ccctgccgga gcctccgctg ccagcgacat gttcaaggta attcagaggt 240 ccgtggggcc agccagcctg agcttgctca ccttcaaagt ctatgcagca ccaaaaaagg 300 actcacctcc caaaaattcc gtgaaggttg atgagctttc actctactca gttcctgagg 360 gtcaatcgaa gtatgtggag gaggcaagga gccagcttga agaaagcatc tcacagctcc 420 gacactattg cgagccatac acaacctggt gtcaggaaac gtactcccaa actaagccca 480 agatgcaaag tttggttcaa tgggggttag acagctatga ctatctccaa aatgcacctc 540 ctggattttt tccgagactt ggtgttattg gttttgctgg ccttattgga ctccttttgg 600 ctagaggttc aaaaataaag aagctagtgt atccgcctgg tttcatggga ttagctgcct 660 ccctctatta tccacaacaa gccatcgtgt ttgcccaggt cagtggggag agattatatg 720 actggggttt acgaggatat atagtcatag aagatttgtg gaaggagaac tttcaaaagc 780 caggaaatgt gaagaattca cctggaacta agtagaaaac tccatgctct gccatcttaa 840 tcagttatag gtaaacattg gaaactccat agaataaatc agtatttcta cagaaaaatg 900 gcatagaagt cagtattgaa tgtattaaat tggctttctt cttcaggaaa aactagacca 960 gacctctgtt atcttctgtg aaatcatcct acaagcaaac taacctggaa tcccttcacc 1020 tagagataat gtacaagcct tagaactcct cattctcatg ttgctattta tgtacctaat 1080 taaaacccaa gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1124 <210> 47 <211> 2967 <212> DNA <213> Homo sapiens <400> 47 agtgcggacg tcgccattcc tggcccatgg gaagattgcg tttcacctgc tcctgaaggc 60 cgaaggtggc tctagcgcat cctttgtcgc gccgtgacct gcaggtactg acagatccgt 120 agggaggaca ccgtgacttc ccggacgctg ggaaatggac tcagtctcct ttgaggatgt 180 ggccgtgaac ttcaccctgg aggagtgggc tttgctggat tcttcacaga aaaagctcta 240 tgaagatgtg atgcaggaga ccttcaaaaa cctggtttgt ctaggaaaaa agtgggaaga 300 ccaggacatt gaagatgacc acagaaacca ggggaaaaat cgaagatgtc atatggttga 360 gagactctgt gaaagtagaa gaggtagcaa atgtggagaa accactagcc agatgccaaa 420 tgttaatatc aacaaggaaa cttttactgg agcaaaacca catgaatgca gcttttgtgg 480 aagagacttc attcatcatt cgtcccttaa taggcacatg agatctcaca ctggacagaa 540 accaaatgag tatcaggaat atgaaaagca accatgtaaa tgtaaagcag ttgggaaaac 600 cttcagttat caccactgct ttcgcaaaca tgaaagaact cacactggag tgaagcccta 660 tgaatgtaaa cagtgtggga aagcctttat atattaccag ccatttcaaa gacatgaaag 720 gactcatgct ggacagaaac cctatgaatg taagcaatgt ggaaaaacct ttatatatta 780 ccagtctttt caaaaacatg ctcatactgg aaagaaaccc tatgaatgta aacagtgtgg 840 gaaagccttt atatgttacc aatcttttca aagacacaaa aggactcaca ctggagagaa 900 accctatgaa tgtaagcaat gtggtaaggc tttcagttgt cccacatact ttcgaactca 960 tgaaagaact cacactggag aaaaacccta caaatgtaaa gaatgtggta aagccttcag 1020 ttttctcagt tcttttcgaa ggcataaaag gactcatagt ggagagaaac cctatgaatg 1080 taaagaatgt ggaaaagcct tcttttattc tgcaagcttt cgagcacatg taataataca 1140 cactggggct cgaccttata aatgtaaaga atgtgggaaa gccttcaact cttctaattc 1200 ctgtcgagtg catgaaagaa ctcatattgg agaaaaacca tatgaatgta aacgatgtgg 1260 caaatcattc agttggtcca tttctcttcg attgcatgaa agaactcata ctggagagaa 1320 accttatgag tgtaaacagt gtcataaaac cttcagtttt tcaagttccc ttcgagaaca 1380 cgaaacaact cacactggag agaaacccta tgaatgtaaa caatgtggta aaaccttcag 1440 tttttcaagt tcccttcaaa gacatgaaag gactcacaat gcagagaaac cctatgaatg 1500 taaacagtgt gggaaagcct tcaggtgttc aagttatttt cgaattcatg aaaggtcaca 1560 cactggagag aaaccctatg aatgtaaaca gtgtggaaaa gttttcattc gttccagttc 1620 ctttcgactg catgaaagaa cacacactgg agagaaaccc tatgaatgta aactatgcgg 1680 taaaaccttc agtttttcaa gttcccttcg agaacatgaa aaaattcaca ctggaaataa 1740 gccttttgag tgtaagcaat gtggtaaggc cttccttcgt tccagtcaaa ttcgattgca 1800 tgaaaggact cacactggag agaaaccgta tcaatgtaaa caatgtggaa aagccttcat 1860 ttcttccagt aaatttcgaa tgcatgagag aactcacacg ggagagaaac cctatcgatg 1920 taaacaatgt gggaaagcct tcagattttc aagttctgtt cgaattcatg aaaggtctca 1980 cactggagag aaaccttatg aatgcaaaca atgtggaaaa gccttcattt cttccagtca 2040 ctttcgactg catgaaagga ctcatatggg agagaaagtc taagaatata agcaacattc 2100 tgaagccttc ggttgttcca gctccttctg aatacacaaa agagttcata ctggacagaa 2160 gctgtgtgaa tacaaacatt gttctaaagc ccttaattgt tccagtttct tttgagcacg 2220 aaagaattcc cactggtgag aaacagtatg aatgtaaaca ttgtgattaa gccttcagtt 2280 gacctaattc atttcaaaga caggactcgt gctgcagtga aatctgtttt gttttttgtt 2340 ttttgttttt ttaaaaaagg ccaagcttgt tggctcatgc ctatagtccc agcactttgg 2400 gaggccaagg tgcaaggcag gcagatcatt tgaggtcaga aattcgagac cagcgtggtc 2460 aacatggtgt aaccccatct ctactaaaaa ttaccaaaaa atgaaccagg catggtagtg 2520 catgcctcta atcccagcta ctcaggaggc taaggcagga gaatcacttg aacctggaga 2580 cagaggttgc agtgagctga gatcacgcca ctgcattcca gcctgtgcga cagaatgaga 2640 cactgtctca agaaaaaata aaagtgggaa aatcttccaa ctgtcctcta gagtgtgaat 2700 atatgaaagg agtcagagtg gggtgaaagt ctataaatgt aagacatttg ggaaagcctt 2760 cacacagcct tttgagcaca catgagaatg tatactggag agaaacccta taaatattaa 2820 gaatgtggga aattcttcat cctagttctt ttgttgttgt tgatgataca aaaatatttt 2880 catttaataa agattgtcag gttatattta ataagaaaga aagtatcatg taaacagccc 2940 agtaataaaa ttttacaatc ttaaaaa 2967 <210> 48 <211> 1725 <212> DNA <213> Homo sapiens <400> 48 acgtccgggg aggggccagg tgagcggcag acccggcacg caggtggggg ccggcggggt 60 ccgtggccag agctgcagag agacaaggcg gcggcggctg ctgtgctggg tgcagtgagg 120 aagaggccct cggtggtgcc catggctggc caggatcctg cgctgagcac gagtcacccg 180 ttctacgacg tggccagaca tggcattctg caggtggcag gggatgaccg ctttggaaga 240 cgtgttgtca cgttcagctg ctgccggatg ccaccctccc acgagctgga ccaccagcgg 300 ctgctggagt atttgaagta cacactggac caatacgttg agaacgatta taccatcgtc 360 tatttccact acgggctgaa cagccggaac aagccttccc tgggctggct ccagagcgca 420 tacaaggagt tcgataggaa agacggggat ctcactatgt ggcccaggct ggtctcgaac 480 tccaagctca agcgatcctc ccacctcagc ctcccaaagt actgggatta caggtacaag 540 aagaacttga aggccctcta cgtggtgcac cccaccagct tcatcaaggt cctgtggaac 600 atcttgaagc ccctcatcag tcacaagttt gggaagaaag tcatctattt caactacctg 660 agtgagctcc acgaacacct taaatacgac cagctggtca tccctcccga agttttgcgg 720 tacgatgaga agctccagag cctgcacgag ggccggacgc cgcctcccac caagacacca 780 ccgccgcggc ccccgctgcc cacacagcag tttggcgtca gtctgcaata cctcaaagac 840 aaaaatcaag gcgaactcat cccccctgtg ctgaggttca cagtgacgta cctgagagag 900 aaaggcctgc gcaccgaggg cctgttccgg agatccgcca gcgtgcagac cgtccgcgag 960 atccagaggc tctacaacca agggaagccc gtgaactttg acgactacgg ggacattcac 1020 atccctgccg tgatcctgaa gaccttcctg cgagagctgc cccagccgct tctgaccttc 1080 caggcctacg agcagattct cgggatcacc tgtgtggaga gcagcctgcg tgtcactggc 1140 tgccgccaga tcttacggag cctcccagag cacaactacg tcgtcctccg ctacctcatg 1200 ggcttcctgc atgcggtgtc ccgggagagc atcttcaaca aaatgaacag ctctaacctg 1260 gcctgtgtct tcgggctgaa tttgatctgg ccatcccagg gggtctcctc cctgagtgcc 1320 cttgtgcccc tgaacatgtt cactgaactg ctgatcgagt actatgaaaa gatcttcagc 1380 accccggagg cacctgggga gcacggcctg gcaccatggg aacaggggag cagggcagcc 1440 cctttgcagg aggctgtgcc acggacacaa gccacgggcc tcaccaagcc taccctacct 1500 ccgagtcccc tgatggcagc cagaagacgt ctctagtgtt gcgaacactc tgtatatttc 1560 gagctacctc ccacacctgt ctgtgcactt gtatgttttg taaacttggc atctgtaaaa 1620 ataaccagcc attagatgaa ttcagaacct tctaatgaaa actccatgcc tctggtcctt 1680 ggactcttgt ccatggttcc tgagctgtgg accgggatag aataa 1725 <210> 49 <211> 1632 <212> DNA <213> Homo sapiens <400> 49 acgtccgggg aggggccagg tgagcggcag acccggcacg caggtggggg ccggcggggt 60 ccgtggccag agctgcagag agacaaggcg gcggcggctg ctgtgctggg tgcagtgagg 120 aagaggccct cggtggtgcc catggctggc caggatcctg cgctgagcac gagtcacccg 180 ttctacgacg tggccagaca tggcattctg caggtggcag gggatgaccg ctttggaaga 240 cgtgttgtca cgttcagctg ctgccggatg ccaccctccc acgagctgga ccaccagcgg 300 ctgctggagt atttgaagta cacactggac caatacgttg agaacgatta taccatcgtc 360 tatttccact acgggctgaa cagccggaac aagccttccc tgggctggct ccagagcgca 420 tacaaggagt tcgataggaa gtacaagaag aacttgaagg ccctctacgt ggtgcacccc 480 accagcttca tcaaggtcct gtggaacatc ttgaagcccc tcatcagtca caagtttggg 540 aagaaagtca tctatttcaa ctacctgagt gagctccacg aacaccttaa atacgaccag 600 ctggtcatcc ctcccgaagt tttgcggtac gatgagaagc tccagagcct gcacgagggc 660 cggacgccgc ctcccaccaa gacaccaccg ccgcggcccc cgctgcccac acagcagttt 720 ggcgtcagtc tgcaatacct caaagacaaa aatcaaggcg aactcatccc ccctgtgctg 780 aggttcacag tgacgtacct gagagagaaa ggcctgcgca ccgagggcct gttccggaga 840 tccgccagcg tgcagaccgt ccgcgagatc cagaggctct acaaccaagg gaagcccgtg 900 aactttgacg actacgggga cattcacatc cctgccgtga tcctgaagac cttcctgcga 960 gagctgcccc agccgcttct gaccttccag gcctacgagc agattctcgg gatcacctgt 1020 gtggagagca gcctgcgtgt cactggctgc cgccagatct tacggagcct cccagagcac 1080 aactacgtcg tcctccgcta cctcatgggc ttcctgcatg cggtgtcccg ggagagcatc 1140 ttcaacaaaa tgaacagctc taacctggcc tgtgtcttcg ggctgaattt gatctggcca 1200 tcccaggggg tctcctccct gagtgccctt gtgcccctga acatgttcac tgaactgctg 1260 atcgagtact atgaaaagat cttcagcacc ccggaggcac ctggggagca cggcctggca 1320 ccatgggaac aggggagcag ggcagcccct ttgcaggagg ctgtgccacg gacacaagcc 1380 acgggcctca ccaagcctac cctacctccg agtcccctga tggcagccag aagacgtctc 1440 tagtgttgcg aacactctgt atatttcgag ctacctccca cacctgtctg tgcacttgta 1500 tgttttgtaa acttggcatc tgtaaaaata accagccatt agatgaattc agaaccttct 1560 aatgaaaact ccatgcctct ggtccttgga ctcttgtcca tggttcctga gctgtggacc 1620 gggatagaat aa 1632 <210> 50 <211> 11389 <212> DNA <213> Homo sapiens <400> 50 atggcgccgc cgccgccgcc cgtgctgccc gtgctgctgc tcctggccgc cgccgccgcc 60 ctgccggcga tggggctgcg agcggccgcc tgggagccgc gcgtacccgg cgggacccgc 120 gccttcgccc tccggcccgg ctgtacctac gcggtgggcg ccgcttgcac gccccgggcg 180 ccgcgggagc tgctggacgt gggccgcgat gggcggctgg caggacgtcg gcgcgtctcg 240 ggcgcggggc gcccgctgcc gctgcaagtc cgcttggtgg cccgcagtgc cccgacggcg 300 ctgagccgcc gcctgcgggc gcgcacgcac cttcccggct gcggagcccg tgcccggctc 360 tgcggaaccg gtgcccggct ctgcggggcg ctctgcttcc ccgtccccgg cggctgcgcg 420 gccgcgcagc attcggcgct cgcagctccg accaccttac ccgcctgccg ctgcccgccg 480 cgccccaggc cccgctgtcc cggccgtccc atctgcctgc cgccgggcgg ctcggtccgc 540 ctgcgtctgc tgtgcgccct gcggcgcgcg gctggcgccg tccgggtggg actggcgctg 600 gaggccgcca ccgcggggac gccctccgcg tcgccatccc catcgccgcc cctgccgccg 660 aacttgcccg aagcccgggc ggggccggcg cgacgggccc ggcggggcac gagcggcaga 720 gggagcctga agtttccgat gcccaactac caggtggcgt tgtttgagaa cgaaccggcg 780 ggcaccctca tcctccagct gcacgcgcac tacaccatcg agggcgagga ggagcgcgtg 840 agctattaca tggaggggct gttcgacgag cgctcccggg gctacttccg aatcgactct 900 gccacgggcg ccgtgagcac ggacagcgta ctggaccgcg agaccaagga gacgcacgtc 960 ctcagggtga aagccgtgga ctacagtacg ccgccgcgct cggccaccac ctacatcact 1020 gtcttggtca aagacaccaa cgaccacagc ccggtcttcg agcagtcgga gtaccgcgag 1080 cgcgtgcggg agaacctgga ggtgggctac gaggtgctga ccatccgcgc cagcgaccgc 1140 gactcgccca tcaacgccaa cttgcgttac cgcgtgttgg ggggcgcgtg ggacgtcttc 1200 cagctcaacg agagctctgg cgtggtgagc acacgggcgg tgctggaccg ggaggaggcg 1260 gccgagtacc agctcctggt ggaggccaac gaccaggggc gcaatccggg cccgctcagt 1320 gccacggcca ccgtgtacat cgaggtggag gacgagaacg acaactaccc ccagttcagc 1380 gagcagaact acgtggtcca ggtgcccgag gacgtggggc tcaacacggc tgtgctgcga 1440 gtgcaggcca cggaccggga ccagggccag aacgcggcca ttcactacag catcctcagc 1500 gggaacgtgg ccggccagtt ctacctgcac tcgctgagcg ggatcctgga tgtgatcaac 1560 cccttggatt tcgaggatgt ccagaaatac tcgctgagca ttaaggccca ggatgggggc 1620 cggcccccgc tcatcaattc ttcaggggtg gtgtctgtgc aggtgctgga tgtcaacgac 1680 aacgagccta tctttgtgag cagccccttc caggccacgg tgctggagaa tgtgcccctg 1740 ggctaccccg tggtgcacat tcaggcggtg gacgcggact ctggagagaa cgcccggctg 1800 cactatcgcc tggtggacac ggcctccacc tttctggggg gcggcagcgc tgggcctaag 1860 aatcctgccc ccacccctga cttccccttc cagatccaca acagctccgg ttggatcaca 1920 gtgtgtgccg agctggaccg cgaggaggtg gagcactaca gcttcggggt ggaggcggtg 1980 gaccacggct cgccccccat gagctcctcc accagcgtgt ccatcacggt gctggacgtg 2040 aatgacaacg acccggtgtt cacgcagccc acctacgagc ttcgtctgaa tgaggatgcg 2100 gccgtgggga gcagcgtgct gaccctgcag gcccgcgacc gtgacgccaa cagtgtgatt 2160 acctaccagc tcacaggcgg caacacccgg aaccgctttg cactcagcag ccagagaggg 2220 ggcggcctca tcaccctggc gctacctctg gactacaagc aggagcagca gtacgtgctg 2280 gcggtgacag catccgacgg cacacggtcg cacactgcgc atgtcctaat caacgtcact 2340 gatgccaaca cccacaggcc tgtctttcag agctcccatt acacagtgag tgtcagtgag 2400 gacaggcctg tgggcacctc cattgctacc ctcagtgcca acgatgagga cacaggagag 2460 aatgcccgca tcacctacgt gattcaggac cccgtgccgc agttccgcat tgaccccgac 2520 agtggcacca tgtacaccat gatggagctg gactatgaga accaggtcgc ctacacgctg 2580 accatcatgg cccaggacaa cggcatcccg cagaaatcag acaccaccac cctagagatc 2640 ctcatcctcg atgccaatga caatgcaccc cagttcctgt gggatttcta ccagggttcc 2700 atctttgagg atgctccacc ctcgaccagc atcctccagg tctctgccac ggaccgggac 2760 tcaggtccca atgggcgtct gctgtacacc ttccagggtg gggacgacgg cgatggggac 2820 ttctacatcg agcccacgtc cggtgtgatt cgcacccagc gccggctgga ccgggagaat 2880 gtggccgtgt acaacctttg ggctctggct gtggatcggg gcagtcccac tccccttagc 2940 gcctcggtag aaatccaggt gaccatcttg gacattaatg acaatgcccc catgtttgag 3000 aaggacgaac tggagctgtt tgttgaggag aacaacccag tggggtcggt ggtggcaaag 3060 attcgtgcta acgaccctga tgaaggccct aatgcccaga tcatgtatca gattgtggaa 3120 ggggacatgc ggcatttctt ccagctggac ctgctcaacg gggacctgcg tgccatggtg 3180 gagctggact ttgaggtccg gcgggagtat gtgctggtgg tgcaggccac gtcggctccg 3240 ctggtgagcc gagccacggt gcacatcctt ctcgtggacc agaatgacaa cccgcctgtg 3300 ctgcccgact tccagatcct cttcaacaac tatgtcacca acaagtccaa cagtttcccc 3360 accggcgtga tcggctgcat cccggcccat gaccccgacg tgtcagacag cctcaactac 3420 accttcgtgc agggcaacga gctgcgcctg ttgctgctgg accccgccac gggcgaactg 3480 cagctcagcc gcgacctgga caacaaccgg ccgctggagg cgctcatgga ggtgtctgtg 3540 tctgatggca tccacagcgt cacggccttc tgcaccctgc gtgtcaccat catcacggac 3600 gacatgctga ccaacagcat cactgtccgc ctggagaaca tgtcccagga gaagttcctg 3660 tccccgctgc tggccctctt cgtggagggg gtggccgccg tgctgtccac caccaaggac 3720 gacgtcttcg tcttcaacgt ccagaacgac accgacgtca gctccaacat cctgaacgtg 3780 accttctcgg cgctgctgcc tggcggcgtc cgcggccagt tcttcccgtc ggaggacctg 3840 caggagcaga tctacctgaa tcggacgctg ctgaccacca tctccacgca gcgcgtgctg 3900 cccttcgacg acaacatctg cctgcgcgag ccctgcgaga actacatgaa gtgcgtgtcc 3960 gttctgcgat tcgacagctc cgcgcccttc ctcagctcca ccaccgtgct cttccggccc 4020 atccacccca tcaacggcct gcgctgccgc tgcccgcccg gcttcaccgg cgactactgc 4080 gagacggaga tcgacctctg ctactccgac ccgtgcggcg ccaacggccg ctgccgcagc 4140 cgcgagggcg gctacacctg cgagtgcttc gaggacttca ctggagagca ctgtgaggtg 4200 gatgcccgct caggccgctg tgccaacggg gtgtgcaaga acgggggcac ctgcgtgaac 4260 ctgctcatcg gcggcttcca ctgcgtgtgt cctcctggcg agtatgagag gccctactgt 4320 gaggtgacca ccaggagctt cccgccccag tccttcgtca ccttccgggg cctgagacag 4380 cgcttccact tcaccatctc cctcacgttt gccactcagg aaaggaacgg cttgcttctc 4440 tacaacggcc gcttcaatga gaagcacgac ttcatcgccc tggagatcgt ggacgagcag 4500 gtgcagctca ccttctctgc aggcgagaca acaacgaccg tggcaccgaa ggttcccagt 4560 ggtgtgagtg acgggcggtg gcactctgtg caggtgcagt actacaacaa gcccaatatt 4620 ggccacctgg gcctgcccca tgggccgtcc ggggaaaaga tggccgtggt gacagtggat 4680 gattgtgaca caaccatggc tgtgcgcttt ggaaaggaca tcgggaacta cagctgcgct 4740 gcccagggca ctcagaccgg ctccaagaag tccctggatc tgaccggccc tctactcctg 4800 gggggtgtcc ccaacctgcc agaagacttc ccagtgcaca accggcagtt cgtgggctgc 4860 atgcggaacc tgtcagtcga cggcaaaaat gtggacatgg ccggattcat cgccaacaat 4920 ggcacccggg aaggctgcgc tgctcggagg aacttctgcg atgggaggcg gtgtcagaat 4980 ggaggcacct gtgtcaacag gtggaatatg tatctgtgtg agtgtccact ccgattcggc 5040 gggaagaact gtgagcaagc catgcctcac ccccagctct tcagcggtga gagcgtcgtg 5100 tcctggagtg acctgaacat catcatctct gtgccctggt acctggggct catgttccgg 5160 acccggaagg aggacagcgt tctgatggag gccaccagtg gtgggcccac cagctttcgc 5220 ctccagatcc tgaacaacta cctccagttt gaggtgtccc acggcccctc cgatgtggag 5280 tccgtgatgc tgtccgggtt gcgggtgacc gacggggagt ggcaccacct gctgatcgag 5340 ctgaagaatg ttaaggagga cagtgagatg aagcacctgg tcaccatgac cttggactat 5400 gggatggacc agaacaaggc agatatcggg ggcatgcttc ccgggctgac ggtaaggagc 5460 gtggtggtcg gaggcgcctc tgaagacaag gtctccgtgc gccgtggatt ccgaggctgc 5520 atgcagggag tgaggatggg ggggacgccc accaacgtcg ccaccctgaa catgaacaac 5580 gcactcaagg tcagggtgaa ggacggctgt gatgtggacg acccctgtac ctcgagcccc 5640 tgtcccccca atagccgctg ccacgacgcc tgggaggact acagctgcgt ctgtgacaaa 5700 gggtaccttg gaataaactg tgtggatgcc tgtcacctga acccctgcga gaacatgggg 5760 gcctgcgtgc gctcccccgg ctccccgcag ggctacgtgt gcgagtgtgg gcccagtcac 5820 tacgggccgt actgtgagaa caaactcgac cttccgtgcc ccagaggctg gtgggggaac 5880 cccgtctgtg gaccctgcca ctgtgccgtc agcaaaggct ttgatcccga ctgtaataag 5940 accaacggcc agtgccaatg caaggagaat tactacaagc tcctagccca ggacacctgt 6000 ctgccctgcg actgcttccc ccatggctcc cacagccgca cttgcgacat ggccaccggg 6060 cagtgtgcct gcaagcccgg cgtcatcggc cgccagtgca accgctgcga caacccgttt 6120 gccgaggtca ccacgctcgg ctgtgaagtg atctacaatg gctgtcccaa agcatttgag 6180 gccggcatct ggtggccaca gaccaagttc gggcagccgg ctgcggtgcc atgccctaag 6240 ggatccgttg gaaatgcggt ccgacactgc agcggggaga agggctggct gcccccagag 6300 ctctttaact gtaccaccat ctccttcgtg gacctcaggg ccatgaatga gaagctgagc 6360 cgcaatgaga cgcaggtgga cggcgccagg gccctgcagc tggtgagggc gctgcgcagt 6420 gctacacagc acacgggcac gctctttggc aatgacgtgc gcacggccta ccagctgctg 6480 ggccacgtcc ttcagcacga gagctggcag cagggcttcg acctggcagc cacgcaggac 6540 gccgactttc acgaggacgt catccactcg ggcagcgccc tcctggcccc agccaccagg 6600 gcggcgtggg agcagatcca gcggagcgag ggcggcacgg cacagctgct ccggcgcctc 6660 gagggctact tcagcaacgt ggcacgcaac gtgcggcgga cgtacctgcg gcccttcgtc 6720 atcgtcaccg ccaacatgat tcttgctgtc gacatctttg acaagttcaa ctttacggga 6780 gccagggtcc cgcgattcga caccatccat gaagagttcc ccagggagct ggagtcctcc 6840 gtctccttcc cagccgactt cttcagacca cctgaagaaa aagaaggccc cctgctgagg 6900 ccggctggcc ggaggaccac cccgcagacc acgcgcccgg ggcctggcac cgagagggag 6960 gccccgatca gcaggcggag gcgacaccct gatgacgctg gccagttcgc cgtcgctctg 7020 gtcatcattt accgcaccct ggggcagctc ctgcccgagc gctacgaccc cgaccgtcgc 7080 agcctccggt tgcctcaccg gcccatcatt aataccccga tggtgagcac gctggtgtac 7140 agcgaggggg ctccgctccc gagacccctg gagaggcccg tcctggtgga gttcgccctg 7200 ctggaggtgg aggagcgaac caagcctgtc tgcgtgttct ggaaccactc cctggccgtt 7260 ggtgggacgg gagggtggtc tgcccggggc tgcgagctcc tgtccaggaa ccggacacat 7320 gtcgcctgcc agtgcagcca cacagccagc tttgcggtgc tcatggatat ctccaggcgt 7380 gagaacgggg aggtcctgcc tctgaagatt gtcacctatg ccgctgtgtc cttgtcactg 7440 gcagccctgc tggtggcctt cgtcctcctg agcctggtcc gcatgctgcg ctccaacctg 7500 cacagcattc acaagcacct cgccgtggcg ctcttcctct ctcagctggt gttcgtgatt 7560 gggatcaacc agacggaaaa cccgtttctg tgcacagtgg ttgccatcct cctccactac 7620 atctacatga gcacctttgc ctggaccctc gtggagagcc tgcatgtcta ccgcatgctg 7680 accgaggtgc gcaacatcga cacggggccc atgcggttct actacgtcgt gggctggggc 7740 atcccggcca ttgtcacagg actggcggtc ggcctggacc cccagggcta cgggaacccc 7800 gacttctgct ggctgtcgct tcaagacacc ctgatttgga gctttgcggg gcccatcgga 7860 gctgttataa tcatcaacac agtcacttct gtcctatctg caaaggtttc ctgccaaaga 7920 aagcaccatt attatgggaa aaaagggatc gtctccctgc tgaggaccgc attcctcctg 7980 ctgctgctca tcagcgccac ctggctgctg gggctgctgg ctgtgaaccg cgatgcactg 8040 agctttcact acctcttcgc catcttcagc ggcttacagg gccccttcgt cctccttttc 8100 cactgcgtgc tcaaccagga ggtccggaag cacctgaagg gcgtgctcgg cgggaggaag 8160 ctgcacctgg aggactccgc caccaccagg gccaccctgc tgacgcgctc cctcaactgc 8220 aacaccacct tcggtgacgg gcctgacatg ctgcgcacag acttgggcga gtccaccgcc 8280 tcgctggaca gcatcgtcag ggatgaaggg atccagaagc tcggcgtgtc ctctgggctg 8340 gtgaggggca gccacggaga gccagacgcg tccctcatgc ccaggagctg caaggatccc 8400 cctggccacg attccgactc agatagcgag ctgtccctgg atgagcagag cagctcttac 8460 gcctcctcac actcgtcaga cagcgaggac gatggggtgg gagctgagga aaaatgggac 8520 ccggccaggg gcgccgtcca cagcaccccc aaaggggacg ctgtggccaa ccacgttccg 8580 gccggctggc ccgaccagag cctggctgag agtgacagtg aggaccccag cggcaagccc 8640 cgcctgaagg tggagaccaa ggtcagcgtg gagctgcacc gcgaggagca gggcagtcac 8700 cgtggagagt accccccgga ccaggagagc gggggcgcag ccaggcttgc tagcagccag 8760 cccccagagc agaggaaagg catcttgaaa aataaagtca cctacccgcc gccgctgacg 8820 ctgacggagc agacgctgaa gggccggctc cgggagaagc tggccgactg tgagcagagc 8880 cccacatcct cgcgcacgtc ttccctgggc tctggcggcc ccgactgcgc catcacagtc 8940 aagagccctg ggagggagcc ggggcgtgac cacctcaacg gggtggccat gaatgtgcgc 9000 actgggagcg cccaggccga tggctccgac tctgagaaac cgtgaggcaa gcccgtcacc 9060 ccacacaggc tgcggcatca ccctcagacc ttggagccca aggggccact gcccttgaag 9120 tggagtgggc ccagagtgtg gcggtcccca tggtggcagc cccccgactg atcatccaga 9180 cacaaaggtc ttggttctcc caggagctca gggcctgtca gacctggtga caagtgccaa 9240 aggccacagg catgagggag gcgtggacca ctgggccagc accgctgagt cctaagactg 9300 cagtcaaagc cagaactgag aggggacccc agactgggcc cagaggctgg ccagagttca 9360 ggaacgccgg gcacagacca aagaccgcgg tccagccccg cccaggcggg catctcatgg 9420 cagtgcggac ccgtggctgg cagcccgggc agtcctttgc aaaggcaccc cttgtcttaa 9480 aatcacttcg ctatgtggga aaggtggaga tacttttata tatttgtatg ggactctgag 9540 gaggtgcaac ctgtatatat attgcattcg tgctgacttt gttatcccga gagatccatg 9600 caatgatctc ttgctgtctt ctctgtcaag attgcacagt tgtacttgaa tctggcatgt 9660 gttgacgaaa ctggtgcccc agcagatcaa aggtgggaaa tacgtcagca gtggggctaa 9720 aaccaagcgg ctagaagccc tacagctgcc ttcggccagg aagtgaggat ggtgtgggcc 9780 ctccccgccg gccccctggg tccccagtgt tcgctgtgtg tgcgtttgtc ctctgctgcc 9840 atctgccccg gctgtgtgaa ttcaagacag ggcagtgcag cactaggcag gtgtgaggag 9900 ccctgctgag gtcactgtgg ggcacggttg ccacacggct gtcatttttc acctggtcat 9960 tctgtgacca ccaccccctc ccctcaccgc ctcccaggtg gcccgggagc tgcaggtggg 10020 gatggctttg tcctttgctc ctgctccccg tgggacctgg gaccttaaag cgttgcaggt 10080 tcctgatttg gacagaggtg tggggccttc caggccgtta catacctcct gccaattctc 10140 taactctctg agactgcgag gatctccagg cagggttctc ccctctggag tctgaccaat 10200 tacttcattt tgcttcaaat ggccaattgt gcagagggac aaagccacag ccacactctt 10260 caacggttac caaactgttt ttggaaattc acaccaaggt cgggcccact gcaggcagct 10320 ggcacagcgt ggcccgaggg gctgtggaac gggtcccgga actgtcagac atgtttgatt 10380 ttagcgtttc ctttgttctt caaatcaggt gcccaaataa gtgatcagca cagctgcttc 10440 caaataggag aaaccataaa ataggatgaa aatcaagtaa aatgcaaaga tgtccacact 10500 gttttaaact tgaccctgat gaaaatgtga gcactgttag cagatgccta tgggagagga 10560 aaagcgtatc tgaaaatggt ccaggacagg aggatgaaat gagatcccag agtcctcaca 10620 cctgaatgaa ttatacatgt gccttaccag gtgagtggtc tttcgaagat aaaaaactct 10680 agtcccttta aacgtttgcc cctggcgttt cctaagtacg aaaaggtttt taagtcttcg 10740 aacagtctcc tttcatgact ttaacaggat tctgccccct gaggtgtaat ttttttgttc 10800 tatttttttc cacgtactcc acagccaaca tcacgaggtg taatttttaa tttgatcaga 10860 actgttacca aaaaacaact gtcagtttta ttgagatggg aaaaatgtaa acctattttt 10920 attacttaag actttatggg agagattaga cactggaggt ttttaacaga acgtgtattt 10980 attaatgttc aaaacactgg aattacaaat gagaagagtc tacaataaat taagattttt 11040 gaatttgtac ttctgcggtg ctggtttttc tccacaaaca cccccgcccc tccccatgcc 11100 cagggtggcc gtggaaggga cggtttacgg acgtgcagct gagctgtccg tgtcccatgc 11160 tccctcagcc agtggaacgt gccggaactt tttgtccatt ccctagtagg cctgccacag 11220 cctagatggg cagtttttgt ctttcaccaa atttgaggac tttttttttt tgccattatt 11280 tcttcagttt tcttttcttg cactgatctt tctcctctcc ttctgtgact ccagtgactc 11340 agacgttaga cctcttgatg ttttcccact ggtccctgag gctctgttc 11389 <210> 51 <211> 2112 <212> DNA <213> Homo sapiens <400> 51 tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60 aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120 agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct taccaatgat 180 gcgagctcag agtcaatagc atccttctct aaacaggagg tcatgagtag ctttctgcca 240 gagggagggt gttacgagct gctcactgtg ataggcaaag gatttgagga cctgatgact 300 gtgaatctag caaggtacaa accaacagga gagtacgtga ctgtacggag gattaaccta 360 gaagcttgtt ccaatgagat ggtaacattc ttgcagggcg agctgcatgt ctccaaactc 420 ttcaaccatc ccaatatcgt gccatatcga gccactttta ttgcagacaa tgagctgtgg 480 gttgtcacat cattcatggc atacggttct gcaaaagatc tcatctgtac acacttcatg 540 gatggcatga atgagctggc gattgcttac atcctgcagg gggtgctgaa ggccctcgac 600 tacatccacc acatgggata tgtacacagg agtgtcaaag ccagccacat cctgatctct 660 gtggatggga aggtctacct gtctggtttg cgcagcaacc tcagcatgat aagccatggg 720 cagcggcagc gagtggtcca cgattttccc aagtacagtg tcaaggttct gccgtggctc 780 agccccgagg tcctccagca gaatctccag ggttatgatg ccaagtctga catctacagt 840 gtgggaatca cagcctgtga actggccaac ggccatgtcc cctttaagga tatgcctgcc 900 acccagatgc tgctagagaa actgaacggc acagtgccct gcctgttgga taccagcacc 960 atccccgctg aggagctgac catgagccct tcgcgctcag tggccaactc tggcctgagt 1020 gacagcctga ccaccagcac cccccggccc tccaacggtg actcgccctc ccacccctac 1080 caccgaacct tctcccccca cttccaccac tttgtggagc agtgccttca gcgcaacccg 1140 gatgccaggc ccagtgccag caccctcctg aaccactctt tcttcaagca gatcaagcga 1200 cgtgcctcag aggctttgcc cgaattgctt cgtcctgtca cccccatcac caattttgag 1260 ggcagccagt ctcaggacca cagtggaatc tttggcctgg taacaaacct ggaagagctg 1320 gaggtggacg attgggagtt ctgagcctct gcaaactgtg cgcattctcc agccagggat 1380 gcagaggcca cccagaggcc cttcctgagg gccggccaca ttcccgccct cctgggcaga 1440 ttgggtagaa aggacattct tccaggaaag ttgactgctg actgattggg aaagaaaatc 1500 ctggagagac acttcactgc tccaaggctt ttgagacaca agggaatctc aacaaccagg 1560 gatcaggagg gtccaaagcc gacattccca gtcctgtgag ctcaggtgac ctcctccgca 1620 gaagagagat gctgctctgg ccctgggagc tgaattccaa gcccagggtt tggctcctta 1680 aacccgagga ccgccacctc ttcccagtgc ttgcgaccag cctcattcta tttaactttg 1740 ctctcagatg cctcagatgc tataggtcag tgaaagggca agtagtaagc tgcctgcctc 1800 ccttccctca gacctctccc tcataattcc agagaagggc atttctgtct ttttaagcac 1860 agactaaggc tggaacagtc catccttatc cctcttctgg cttgggccct gacacctaag 1920 tctttcccac ggtttatgtg tgtgcctcat tcctttccca ccaagaatcc atcttagcgc 1980 ctcctgccag ctgccctggt gctttctcca agggccatca gtgtcttgcc tagcttgagg 2040 gcttaagtcc ttatgctgtg ttagtttcgt tgtcagaaca aattaaaatt ttcagagacg 2100 ctgctggaaa aa 2112 <210> 52 <211> 2223 <212> DNA <213> Homo sapiens <400> 52 tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60 aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120 agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct tgtaagtaaa 180 ccagagcgaa tcaggcggtg ggtctcggaa aagttcattg ttgagggctt aagagatttg 240 gaactatttg gagagcagcc tccgggtgac actcggagaa aaaccaatga tgcgagctca 300 gagtcaatag catccttctc taaacaggag gtcatgagta gctttctgcc agagggaggg 360 tgttacgagc tgctcactgt gataggcaaa ggatttgagg acctgatgac tgtgaatcta 420 gcaaggtaca aaccaacagg agagtacgtg actgtacgga ggattaacct agaagcttgt 480 tccaatgaga tggtaacatt cttgcagggc gagctgcatg tctccaaact cttcaaccat 540 cccaatatcg tgccatatcg agccactttt attgcagaca atgagctgtg ggttgtcaca 600 tcattcatgg catacggttc tgcaaaagat ctcatctgta cacacttcat ggatggcatg 660 aatgagctgg cgattgctta catcctgcag ggggtgctga aggccctcga ctacatccac 720 cacatgggat atgtacacag gagtgtcaaa gccagccaca tcctgatctc tgtggatggg 780 aaggtctacc tgtctggttt gcgcagcaac ctcagcatga taagccatgg gcagcggcag 840 cgagtggtcc acgattttcc caagtacagt gtcaaggttc tgccgtggct cagccccgag 900 gtcctccagc agaatctcca gggttatgat gccaagtctg acatctacag tgtgggaatc 960 acagcctgtg aactggccaa cggccatgtc ccctttaagg atatgcctgc cacccagatg 1020 ctgctagaga aactgaacgg cacagtgccc tgcctgttgg ataccagcac catccccgct 1080 gaggagctga ccatgagccc ttcgcgctca gtggccaact ctggcctgag tgacagcctg 1140 accaccagca ccccccggcc ctccaacggt gactcgccct cccaccccta ccaccgaacc 1200 ttctcccccc acttccacca ctttgtggag cagtgccttc agcgcaaccc ggatgccagg 1260 cccagtgcca gcaccctcct gaaccactct ttcttcaagc agatcaagcg acgtgcctca 1320 gaggctttgc ccgaattgct tcgtcctgtc acccccatca ccaattttga gggcagccag 1380 tctcaggacc acagtggaat ctttggcctg gtaacaaacc tggaagagct ggaggtggac 1440 gattgggagt tctgagcctc tgcaaactgt gcgcattctc cagccaggga tgcagaggcc 1500 acccagaggc ccttcctgag ggccggccac attcccgccc tcctgggcag attgggtaga 1560 aaggacattc ttccaggaaa gttgactgct gactgattgg gaaagaaaat cctggagaga 1620 cacttcactg ctccaaggct tttgagacac aagggaatct caacaaccag ggatcaggag 1680 ggtccaaagc cgacattccc agtcctgtga gctcaggtga cctcctccgc agaagagaga 1740 tgctgctctg gccctgggag ctgaattcca agcccagggt ttggctcctt aaacccgagg 1800 accgccacct cttcccagtg cttgcgacca gcctcattct atttaacttt gctctcagat 1860 gcctcagatg ctataggtca gtgaaagggc aagtagtaag ctgcctgcct cccttccctc 1920 agacctctcc ctcataattc cagagaaggg catttctgtc tttttaagca cagactaagg 1980 ctggaacagt ccatccttat ccctcttctg gcttgggccc tgacacctaa gtctttccca 2040 cggtttatgt gtgtgcctca ttcctttccc accaagaatc catcttagcg cctcctgcca 2100 gctgccctgg tgctttctcc aagggccatc agtgtcttgc ctagcttgag ggcttaagtc 2160 cttatgctgt gttagtttcg ttgtcagaac aaattaaaat tttcagagac gctgctggaa 2220 aaa 2223 <210> 53 <211> 2658 <212> DNA <213> Homo sapiens <400> 53 tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60 aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120 agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct taccaatgat 180 gcgagctcag agtcaatagc atccttctct aaacaggagg tcatgagtag ctttctgcca 240 gagggagggt gttacgagct gctcactgtg ataggcaaag gatttgagga cctgatgact 300 gtgaatctag caaggtacaa accaacagga gagtacgtga ctgtacggag gattaaccta 360 gaagcttgtt ccaatgagat ggtaacattc ttgcagggcg agctgcatgt ctccaaactc 420 ttcaaccatc ccaatatcgt gccatatcga gccactttta ttgcagacaa tgagctgtgg 480 gttgtcacat cattcatggc atacggttct gcaaaagatc tcatctgtac acacttcatg 540 gatggcatga atgagctggc gattgcttac atcctgcagg gggtgctgaa ggccctcgac 600 tacatccacc acatgggata tgtacacagg agtgtcaaag ccagccacat cctgatctct 660 gtggatggga aggtctacct gtctggtttg cgcagcaacc tcagcatgat aagccatggg 720 cagcggcagc gagtggtcca cgattttccc aagtacagtg tcaaggttct gccgtggctc 780 agccccgagg tcctccagca gaatctccag ggttatgatg ccaagtctga catctacagt 840 gtgggaatca cagcctgtga actggccaac ggccatgtcc cctttaagga tatgcctgcc 900 acccagatgc tgctagagaa actgaacggc acagtgccct gcctgttgga taccagcacc 960 atccccgctg aggagctgac catgagccct tcgcgctcag tggccaactc tggcctgagt 1020 gacagcctga ccaccagcac cccccggccc tccaacggtg actcgccctc ccacccctac 1080 caccgaacct tctcccccca cttccaccac tttgtggagc agtgccttca gcgcaacccg 1140 gatgccaggt atccctgctg gcctgggcct gggcttcggg agagcagagg gtgctcagga 1200 gggtaaggcc agggtgtgaa gggacttacc tcccaaaggt tctgcagggg aatctggagc 1260 tacacacagg agggatcagc tcctgggtgt gtcagaggcc agcctgggga gctctggcca 1320 ctgcttccca tgagctgagg gagagggaga ggggacccga ggctgaggca taagtggcag 1380 gatttcggga agctggggac acggcagtga tgctgcggtc tctcctcccc tttccctcca 1440 ggcccagtgc cagcaccctc ctgaaccact ctttcttcaa gcaggtatcg tagccccttc 1500 gttctggttc tggttctagt tctggttcta acaactcaca atccctttag ctttctctcc 1560 cctccctttg aatgagagaa actaccccgc ttccgaagcc cctgaaagac actgctcctt 1620 cctctcatgg agttggctcc gacagcccgt ctgccaccag gccatggttc cttgccccat 1680 ggtgtcctgg gacccagagc aacaggatct gtcacccacc tctctcttct cccccagatc 1740 aagcgacgtg cctcagaggc tttgcccgaa ttgcttcgtc ctgtcacccc catcaccaat 1800 tttgagggca gccagtctca ggaccacagt ggaatctttg gcctggtaac aaacctggaa 1860 gagctggagg tggacgattg ggagttctga gcctctgcaa actgtgcgca ttctccagcc 1920 agggatgcag aggccaccca gaggcccttc ctgagggccg gccacattcc cgccctcctg 1980 ggcagattgg gtagaaagga cattcttcca ggaaagttga ctgctgactg attgggaaag 2040 aaaatcctgg agagacactt cactgctcca aggcttttga gacacaaggg aatctcaaca 2100 accagggatc aggagggtcc aaagccgaca ttcccagtcc tgtgagctca ggtgacctcc 2160 tccgcagaag agagatgctg ctctggccct gggagctgaa ttccaagccc agggtttggc 2220 tccttaaacc cgaggaccgc cacctcttcc cagtgcttgc gaccagcctc attctattta 2280 actttgctct cagatgcctc agatgctata ggtcagtgaa agggcaagta gtaagctgcc 2340 tgcctccctt ccctcagacc tctccctcat aattccagag aagggcattt ctgtcttttt 2400 aagcacagac taaggctgga acagtccatc cttatccctc ttctggcttg ggccctgaca 2460 cctaagtctt tcccacggtt tatgtgtgtg cctcattcct ttcccaccaa gaatccatct 2520 tagcgcctcc tgccagctgc cctggtgctt tctccaaggg ccatcagtgt cttgcctagc 2580 ttgagggctt aagtccttat gctgtgttag tttcgttgtc agaacaaatt aaaattttca 2640 gagacgctgc tggaaaaa 2658 <210> 54 <211> 2194 <212> DNA <213> Homo sapiens <400> 54 tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60 aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120 agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct tgtaagtaaa 180 ccagagcgaa tcaggcggtg ggtctcggaa aagttcattg ttgagggctt aagagatttg 240 gaactatttg gagaccaatg atgcgagctc agagtcaata gcatccttct ctaaacagga 300 ggtcatgagt agctttctgc cagagggagg gtgttacgag ctgctcactg tgataggcaa 360 aggatttgag gacctgatga ctgtgaatct agcaaggtac aaaccaacag gagagtacgt 420 gactgtacgg aggattaacc tagaagcttg ttccaatgag atggtaacat tcttgcaggg 480 cgagctgcat gtctccaaac tcttcaacca tcccaatatc gtgccatatc gagccacttt 540 tattgcagac aatgagctgt gggttgtcac atcattcatg gcatacggtt ctgcaaaaga 600 tctcatctgt acacacttca tggatggcat gaatgagctg gcgattgctt acatcctgca 660 gggggtgctg aaggccctcg actacatcca ccacatggga tatgtacaca ggagtgtcaa 720 agccagccac atcctgatct ctgtggatgg gaaggtctac ctgtctggtt tgcgcagcaa 780 cctcagcatg ataagccatg ggcagcggca gcgagtggtc cacgattttc ccaagtacag 840 tgtcaaggtt ctgccgtggc tcagccccga ggtcctccag cagaatctcc agggttatga 900 tgccaagtct gacatctaca gtgtgggaat cacagcctgt gaactggcca acggccatgt 960 cccctttaag gatatgcctg ccacccagat gctgctagag aaactgaacg gcacagtgcc 1020 ctgcctgttg gataccagca ccatccccgc tgaggagctg accatgagcc cttcgcgctc 1080 agtggccaac tctggcctga gtgacagcct gaccaccagc accccccggc cctccaacgg 1140 tgactcgccc tcccacccct accaccgaac cttctccccc cacttccacc actttgtgga 1200 gcagtgcctt cagcgcaacc cggatgccag gcccagtgcc agcaccctcc tgaaccactc 1260 tttcttcaag cagatcaagc gacgtgcctc agaggctttg cccgaattgc ttcgtcctgt 1320 cacccccatc accaattttg agggcagcca gtctcaggac cacagtggaa tctttggcct 1380 ggtaacaaac ctggaagagc tggaggtgga cgattgggag ttctgagcct ctgcaaactg 1440 tgcgcattct ccagccaggg atgcagaggc cacccagagg cccttcctga gggccggcca 1500 cattcccgcc ctcctgggca gattgggtag aaaggacatt cttccaggaa agttgactgc 1560 tgactgattg ggaaagaaaa tcctggagag acacttcact gctccaaggc ttttgagaca 1620 caagggaatc tcaacaacca gggatcagga gggtccaaag ccgacattcc cagtcctgtg 1680 agctcaggtg acctcctccg cagaagagag atgctgctct ggccctggga gctgaattcc 1740 aagcccaggg tttggctcct taaacccgag gaccgccacc tcttcccagt gcttgcgacc 1800 agcctcattc tatttaactt tgctctcaga tgcctcagat gctataggtc agtgaaaggg 1860 caagtagtaa gctgcctgcc tcccttccct cagacctctc cctcataatt ccagagaagg 1920 gcatttctgt ctttttaagc acagactaag gctggaacag tccatcctta tccctcttct 1980 ggcttgggcc ctgacaccta agtctttccc acggtttatg tgtgtgcctc attcctttcc 2040 caccaagaat ccatcttagc gcctcctgcc agctgccctg gtgctttctc caagggccat 2100 cagtgtcttg cctagcttga gggcttaagt ccttatgctg tgttagtttc gttgtcagaa 2160 caaattaaaa ttttcagaga cgctgctgga aaaa 2194

Claims (14)

  1. 하기 단계를 포함하는, EGFR 억제제를 사용한 치료에 대한 암 환자의 반응을 예측하는 시험관내 방법:
    환자의 종양 샘플에서의 표 3에서 선택된 하나 이상의 유전자의 발현 수준을 측정하고, 하나 이상의 유전자의 발현 수준을, EGFR 억제제 치료로부터 임상적 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값에 대해 비교하는 단계 (여기서 환자의 종양 샘플에서의 하나 이상의 유전자의 차등 발현 수준은 치료로부터 임상적 이득을 얻을 환자에 대한 표식임).
  2. 제 1 항에 있어서, 발현 수준을 마이크로어레이 (microarray) 기술로 측정하는 방법.
  3. 제 1 항 또는 제 2 항에 있어서, 두 유전자의 발현 수준을 측정하는 방법.
  4. 제 1 항 내지 제 3 항 중 어느 한 항에 있어서, 세 유전자의 발현 수준을 측정하는 방법.
  5. 제 1 항 내지 제 4 항 중 어느 한 항에 있어서, 유전자가 ATP6V0E1, MAPRE1, PSMA5, ACSL3, RAP1A, SLC2A3, CHMP2B, RFK, CTGF, HSPA8, AKAP12, LOX, SLMO2, NOMO3, APOO로 이루어지는 군에서 선택되며, 상기 유전자가 EGFR 억제제 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 낮은 발현 수준을 나타내는 방법.
  6. 제 1 항 내지 제 4 항 중 어느 한 항에 있어서, 유전자가 SDC1, CEBPA, ST6GALNAC2, PLA2G6, PMS2L11, C19orf7, DDX17, SFPQ, PMS2L3, SLC35E2, PMSL2, URG4, PPP1R13B, NRCAM, FLJ10916, FLJ13197, GPR172B, ZNF506, ARHGAP8, CELSR1, LYK5로 이루어지는 군에서 선택되며, 상기 유전자가 EGFR 억제제 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 높은 발현 수준을 나타내는 방법.
  7. 제 1 항 내지 제 6 항 중 어느 한 항에 있어서, EGFR 억제제가 에를로티니브인 방법.
  8. 제 1 항 내지 제 7 항 중 어느 한 항에 있어서, 암이 NSCLC인 방법.
  9. EGFR 억제제 치료에 대한 암 환자의 반응을 예측하기 위한 표 3에 열거된 유전자의 용도.
  10. 제 9 항에 있어서, 암이 NSCLC인 용도.
  11. 제 9 항 또는 제 10 항에 있어서, EGFR 억제제가 에를로티니브인 용도.
  12. EGFR 억제제를 환자에게 투여하는 것을 포함하는, 제 1 항 내지 제 8 항 중 어느 한 항에 따른 방법에 의해 확인되는 암 환자 치료 방법.
  13. 제 12 항에 있어서, EGFR 억제제가 에를로티니브인 방법.
  14. 제 12 항 또는 제 13 항에 있어서, 암이 NSCLC인 방법.
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