KR20050092658A

KR20050092658A - Genes with activity forming hair follicle

Info

Publication number: KR20050092658A
Application number: KR1020040017777A
Authority: KR
Inventors: 김정철; 김문규; 민복기
Original assignee: 경북대학교 산학협력단
Priority date: 2004-03-16
Filing date: 2004-03-16
Publication date: 2005-09-22
Also published as: KR100560734B1

Abstract

본 발명은 계대배양을 한번도 하지 않은 상태의 모유두(dermal papilla) 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 모낭형성능력을 가진 유전자에 대한 발명이다. The present invention is directed to a gene having a hair follicle forming ability specifically expressed in dermal papilla cells (passage 0 (DP0 state) that has never been passaged.

Description

모낭형성능력을 가지는 유전자{Genes with activity forming hair follicle} Genes with hair follicle forming ability {Genes with activity forming hair follicle}

본 발명은 모낭형성능력을 가지는 유전자에 관한 발명으로 더욱 상세하게는 계대를 한번도 하지 않은 상태의 모유두 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 유전자에 관한 발명이다.The present invention relates to a gene having a hair follicle forming ability. More particularly, the present invention relates to a gene specifically expressed in papillary cells (passage 0; DP0 state) that has never been passaged.

일반적으로 모낭의 발생 및 주기적 재생은 상피 및 간엽 세포군 간의 상호작용에 의하여 조절된다(Hardy, M.H. Trends Genet. 8: 55-61. (1992); Stenn, K.S., 등 Physiol Rev. 81(1):449-494 (2001)). 모낭에서 상피 및 간엽 세포들 간에는 서로 많은 근거리 신호들에 의해 상호작용하고, 몇 층으로 분화하여 모축(hair shaft), 근초(root sheaths) 및 모유두(dermal papilla)를 형성한다(Hardy, M.H. Trends Genet. 8: 55-61. (1992);Millar SE. J Invest Dermatol 2002 Feb;118(2):216-25 (2002)).In general, hair follicle development and periodic regeneration are regulated by interactions between epithelial and mesenchymal cell populations (Hardy, MH Trends Genet. 8: 55-61. (1992); Stenn, KS, et al. Physiol Rev. 81 (1): 449-494 (2001)). In the hair follicles, epithelial and mesenchymal cells interact with each other by many short-range signals and differentiate into several layers to form hair shafts, root sheaths and dermal papillas (Hardy, MH Trends Genet). .. 8: 55-61 (1992) ; Millar SE J Invest Dermatol 2002 Feb; 118 (2):. 216-25 (2002)).

모낭에 있는 많은 세포군 중에서, 상피 모 초기세포(placode) 아래에 있는 응집된(condensed) 간엽세포에서 기원하고 모낭의 베이스에 위치한 모유두(dermal papilla;DP)는 모발(hair)의 발생, 성장 및 주기의 유지에 중요한 역할을 한다(Oliver RF, 등 Clin Dermatol. 6(4):74-82 (1988); Jahoda, CAB, 등 Nature, 311, 560-562 (1984)). 모발 주기에 대한 최근의 가설은 모낭의 다른 콤포넌트에 영향을 주는 조절인자의 생성을 변화시키는 모유두 세포에 작용하는 여러 조절인자가 관여한다는 것이다(Randall VA, 등 Ann. NY Acad. Sci., 642:355-375 (1991); Randall VA Clin. Endocrinol., 40:439-457 (1994)). 최근 연구는 모낭 발생의 초기 단계에서 fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), sonic hedgehog (Shh), 및 Wnt 계열 단백질(Millar SE. 등 J Invest Dermatol 2002 Feb;118(2):216-25 (2002) ;Jiro Kishimoto, 등 Gene & Development 14:1181-1185 (2000))과 같은 모 발생에 중요한 몇 신호물질을 밝혀냈다(Oro AE, 등 Cell. 1998 Nov 25;95(5):575-8). 그러나 피부 응집(condensation) 과정 또는 새로운 성장기(anagne) 모발 생성에 대한 시작 인자에서 직접적인 작용을 갖는 간엽에서 표적 유전자들에 대해서는 거의 알려져 있지 않다.Among many cell populations in hair follicles, dermal papilla (DP) originating from condensed mesenchymal cells under the epidermal placode and located at the base of hair follicles is known as hair development, growth and cycle. Play an important role in the maintenance of (Oliver RF, et al. Clin Dermatol. 6 (4): 74-82 (1988); Jahoda, CAB, et al. Nature, 311, 560-562 (1984)). A recent hypothesis about the hair cycle is that several regulators act on the dermal papilla cells that alter the production of regulators that affect other components of the hair follicle (Randall VA, et al. Ann. NY Acad. Sci., 642: 355-375 (1991); Randall VA Clin.Endocrinol., 40: 439-457 (1994)). Recent studies have shown that fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), sonic hedgehog (Shh), and Wnt family proteins (Millar SE. Et al. J Invest Dermatol 2002 Feb; 118 (2): 216 -25 (2002); Jiro Kishimoto, et al. Gene & Development 14: 1181-1185 (2000)). Several signal substances important for parental development have been identified (Oro AE, et al. Cell. 1998 Nov 25; 95 (5): 575. -8). However, little is known about the target genes in the mesenchyme, which has a direct effect on the skin condensation process or on the starting factor for new hair growth.

이식실험을 통하여 신선하게 잘라낸 모유두 세포는 피부아래에 이식되었을 때 모발 성장을 유도할 수 있다는 것을 보여 주었고(Oliver RF. 등 Embryol Exp Morphol Aug;18(1):43-51 (1967); Ibrahaim, 등 Nature, Lond. 265, 733-734. (1977)), 귀 또는 음낭 주머니 표피와 상호작용을 시키면 새로운 모낭의 발생을 유도한다는 것을 알 수 있었다(Oliver, R. F. J. Embryol. exp. Morph. 23, 219-236 (1970)). 모유두세포의 배양은 모낭의 형성을 이끄는 상피-간엽 상호작용의 메카니즘을 찾는 연구자들에게는 유용한 방법이다. 그러한 첫 번째 시도는 유두부에 대한 단일 형태학적 특성을 기술한 래트 수염 모유두(vibrissal papillae)에 대한 Jahoda 및 Oliver(Br J Dermatol 105:623-627 (1981))와 인간 모유두에 대한 Messenger(Br J Dermatol, 110, 685-689. (1984))에 의한 보고에서였다. 래트(Jahoda, 등 Nature, 311, 560-562 (1984)) 및 인간(Katsuoka, 등 In Vitro. Arch Dermatol Res, 279, 20-25, (1986); Messenger, 등 Br J Dermatol, 114, 425-430, (1986); Warren, 등 J Invest Dermatol, 98, 693-699, (1992); Warren, 등 Arch Dermatol Res, 286, 1-5 (1994))의 배양된 모유두세포의 성장능력에 대한 규명을 위한 몇 번의 시도가 있었다. Jahoda 등은 배양된 쥐수염 모유두세포에서 그들의 모발 유도 활성을 가지는 것을 처음으로 밝혔으나 배양에서 모유두세포는 계대 수가 증가하면 그들의 활성을 잃는다는 것이 알려졌다(Horne, KA, 등 J Embryol Exp Morph, 97, 111-124 (1986); Lichti, 등 J Invest Dermatol, 101, 124S-129S (1993); Weinberg, 등 J Invest Dermatol, 100, 229-236 (1993)). 단지 하나의 in vivo DP-특이적인 마커가 보고 되었다. Kishimoto 등은 버시칸(versican)은 in vivo DP 마커이고 버시칸을 발현하는 모유두세포는 모발 유도능을 갖는다고 보고하였다(Jiro Kishimoto, 등 PNAS Vol.96, pp. 7336-7341, June (1999)).Transplantation experiments have shown that freshly cut dermal papilla cells can induce hair growth when implanted under the skin (Oliver RF. Et al Embryol Exp Morphol Aug; 18 (1): 43-51 (1967); Ibrahaim, Nature, Lond. 265, 733-734. (1977)), and interactions with the ear or scrotum pocket epidermis have been shown to induce the development of new hair follicles (Oliver, RFJ Embryol. Exp. Morph. 23, 219). -236 (1970)). Culture of dermal papilla cells is a useful method for researchers looking for a mechanism of epithelial-mesenchymal interaction that leads to hair follicle formation. Such a first attempt was made by Jahoda and Oliver (Br J Dermatol 105: 623-627 (1981)) for rat bearded papillae describing the morphological properties of the papilla and Messenger (Br J) for human dermal papilla. Dermatol, 110, 685-689. (1984)). Rats (Jahoda, et al. Nature, 311, 560-562 (1984)) and humans (Katsuoka, et al. In Vitro. Arch Dermatol Res, 279, 20-25, (1986); Messenger, et al Br J Dermatol, 114, 425- 430, (1986); Warren, et al. J Invest Dermatol, 98, 693-699, (1992); Warren, et al. Arch Dermatol Res, 286, 1-5 (1994)) There have been several attempts for. Jahoda et al. Have shown for the first time that they have their hair-inducing activity in cultured bearded dermal papilla cells, but it has been found that in cultured dermal papilla cells lose their activity as the number of passages increases (Horne, KA, et al. J Embryol Exp Morph, 97, 111-124 (1986); Lichti, et al. J Invest Dermatol, 101, 124S-129S (1993); Weinberg, et al. J Invest Dermatol, 100, 229-236 (1993)). Only one in vivo DP-specific marker was reported. Kishimoto et al. Reported that vertican is an in vivo DP marker and hair papilla cells expressing versican have hair inducing ability (Jiro Kishimoto, et al. PNAS Vol. 96, pp. 7336-7341, June (1999). ).

DNA 마이크로어레이는 한번의 실험으로 수천 개의 유전자들의 발현을 동시에 측정할 수 있는 포맷을 제공한다(Shalon D, 등 Genome Res., 6:639-645 (1996); Schena M, 등 Proc. Natl. Acad. Sci. USA, 93:10614-10619 (1996); Khan J, 등 Proc. Natl. Acad. Sci. USA, 96:13264-13269 (1999); Duggan DJ, 등 Nat. Genet., 21:10-14 (1999); Brown PO, 등 Nat. Genet., 21:33-37 (1999)). 그리고 그것은 이미 가슴 조직(Perou CM, 등 Proc. Natl. Acad. Sci., 96:9212-9217 (1999)), 멜라닌세포(Loftus SK, 등 Proc. Natl. Acad. Sci., 96:9277-9280 (1999)) 및 림프구(Alizadeh AA, 등 Nature, 403:503-511 (2000))와 같은 특정 연구분야에서 조직특이적인 DNA 마이크로어레이를 갖는다는 것은 매우 효율적이고 적당한 것이 될 것이다. DNA microarrays provide a format for simultaneously measuring the expression of thousands of genes in a single experiment (Shalon D, et al. Genome Res., 6: 639-645 (1996); Schena M, et al. Proc. Natl. Acad. Sci. USA, 93: 10614-10619 (1996); Khan J, et al. Proc. Natl. Acad. Sci. USA, 96: 13264-13269 (1999); Duggan DJ, et al. Nat. Genet., 21: 10-. 14 (1999); Brown PO, et al. Nat. Genet., 21: 33-37 (1999). And it has already been described in chest tissues (Perou CM, et al. Proc. Natl. Acad. Sci., 96: 9212-9217 (1999)), melanocytes (Loftus SK, et al. Proc. Natl. Acad. Sci., 96: 9277-9280 (1999) and lymphocytes (Alizadeh AA, et al. Nature, 403: 503-511 (2000)) having tissue specific DNA microarrays would be very efficient and appropriate.

본 발명은 상기의 필요성에 의해 안출된 것으로 본 발명의 목적은 모낭 형성 능력을 갖는 유전자를 제공하는 것이다. The present invention has been made by the above necessity, and an object of the present invention is to provide a gene having hair follicle forming ability.

상기의 목적을 달성하기 위해 본 발명은 콜라겐형 VII(서열번호26), DNA 바인딩 3 저해제(서열번호27), 종양 엔도쎄리얼 마커 6(서열번호28), 사이토키네시스1의 단백질 조절자(서열번호 29), 염색체1q(ch 1q)의 올(ALL)1-융합된 유전자를 코딩하는 단백질(서열번호 30), 포크헤드 박스 M1(서열번호31), 가상(hypothetical) 단백질 FLJ10540(서열번호32), 감마-굴루타밀 하이드로레이즈(서열번호33), 가상 단백질 MGC5576(서열번호34), 프로테오리피드 단백질 2(서열번호35), 가상 단백질 DKFZp434B044(서열번호36), S-아데노실메티오닌 디카르복실레이즈 1(서열번호37), 프레이오트로핀(서열번호38), 알도-케토·리덕테이즈 B1(서열번호39), 신데칸 3(서열번호40), 메탈로프로테이즈 3 조직 인히비터(TIMP-3)(서열번호41), 스프로티 호모로지 4(서열번호42), 트랜스케토레이즈(서열번호43), FXYD 도메인 5(서열번호44), CD9 항원(p24)(서열번호45) 및 프로테오좀 액티베이터 단위체2(서열번호46), 가상 단백질 FLJ22009(서열번호47), SH3-도메인(서열번호48) 및 DKFZp434J214(서열번호49) 단백질로 구성된 군으로부터 선택된 하나의 모낭형성능력을 갖는 단백질을 제공한다.In order to achieve the above object, the present invention provides a collagen type VII (SEQ ID NO: 26), a DNA binding 3 inhibitor (SEQ ID NO: 27), tumor endothelial marker 6 (SEQ ID NO: 28), and a protein regulator of cytokinesis 1 ( SEQ ID NO: 29), Protein encoding an ALL-fused gene of chromosome 1q (ch 1q) (SEQ ID NO: 30), Forkhead box M1 (SEQ ID NO: 31), hypothetical protein FLJ10540 (SEQ ID NO: 32), gamma-gullutamil hydrolase (SEQ ID NO: 33), hypothetical protein MGC5576 (SEQ ID NO: 34), proteolipid protein 2 (SEQ ID NO: 35), hypothetical protein DKFZp434B044 (SEQ ID NO: 36), S-adenosylmethionine Decarboxylase 1 (SEQ ID NO: 37), Freiotropin (SEQ ID NO: 38), Aldo-keto-reductase B1 (SEQ ID NO: 39), Syndecane 3 (SEQ ID NO: 40), metalloprotease 3 tissue Inhibitor (TIMP-3) (SEQ ID NO: 41), Sprotty Homology 4 (SEQ ID NO: 42), Transketases (SEQ ID NO: 43), FXYD domain 5 (SEQ ID NO: 44), CD9 antigen (p24) (SEQ ID NO: 45) and proteosome activator monomer 2 (SEQ ID NO: 46), hypothetical protein FLJ22009 (SEQ ID NO: 47), SH3-domain (SEQ ID NO: 48), and DKFZp434J214 ( SEQ ID NO: 49) provides a protein having one hair follicle forming ability selected from the group consisting of proteins.

또한 본 발명은 상기 단백질을 각각 코딩하는 서열번호1내지 서열번호25 중의 하나의 모낭형성능력을 갖는 단백질을 코딩하는 유전자를 제공한다.The present invention also provides a gene encoding a protein having a hair follicle forming ability of each of SEQ ID NO: 1 to SEQ ID NO: 25 encoding the protein.

이하, 본 발명을 상세하게 설명한다.EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

모유두(dermal papilla)는 모낭의 가장 아래쪽에 존재하는 세포로서 모발의 형성과 모발주기의 조절에 가장 중요한 역할을 하는 세포이다.The dermal papilla is a cell at the bottom of the hair follicle, which is the most important cell for hair formation and regulation of the hair cycle.

모유두세포(dermal papilla cell)는 중배엽에서 유래하였고 현재까지는 섬유아세포(dermal fibroblast)와 가장 유사한 세포로 알려지고 있다.The dermal papilla cells are derived from mesoderm and are known to be the most similar to dermal fibroblasts.

배양된 모유두 세포는 특이하게도 계대배양(passage)을 하지 않은 세포들은 모낭형성 능력이 있는 반면에 배양을 오래 할 수록 (passage 3 -4 이후) 모낭을 형성할 수 있는 능력이 점차 떨어지는 특징이 있다. 즉 실험실에서 세포를 배양할 수록 세포가 원래 가지고 있던 능력을 잃어버린다고 할 수 있다.Cultured dermal papilla cells are characterized by the fact that cells that are not passaged have the ability to form hair follicles, while the ability to form hair follicles gradually decreases as the culture lasts (after passage 3-4). In other words, the more cells are cultured in a laboratory, the more they lose their original capacity.

따라서 배양 초기의 모낭형성 능력을 지니고 있을 때 특이적으로 발현되는 유전자를 알게되면 이를 이용하여 오래 배양된 세포에 어떤 조건을 첨가하였을 때 다시 모낭형성 능력을 가지는 세포가 될 수 있을지 어떨지를 알아낼 수 있는 좋은 marker가 될 수 있다.Therefore, by knowing genes that are specifically expressed when they have hair follicle forming ability at the beginning of culture, it can be used to find out whether they can become a cell having hair follicle forming ability again when certain conditions are added to long cultured cells. It can be a good marker.

따라서 본 발명은 계대배양을 한번도 하지 않은 상태의 dermal papilla 세포 (passage 0; DP0 상태)에서 특이적으로 발현되는 유전자를 제공한다.Accordingly, the present invention provides a gene that is specifically expressed in dermal papilla cells (passage 0 (DP0 state), which has never been passaged.

즉, 본 발명에서는 모 발생 및 주기를 조절하는 모유두세포를 더 잘 이해하기 위해 유전자 수준에서의 유전자 발현 프로화일을 모유두 및 밀접하게 연관된 섬유아세포(dermal fibroblasts)간에 사이에 cDNA 마이크로어레이 기술로 스크리닝하였다. 게다가 장기간 배양에 따른 모유두세포의 변화를 밝히기 위해 유전자 발현 프로화일을 모유두세포의 각 계대에서 비교하였다.That is, in the present invention, gene expression profiles at the gene level were screened by cDNA microarray technology between the dermal papilla and closely related dermal fibroblasts to better understand the dermal papilla cells that regulate hair development and cycle. In addition, gene expression profiles were compared at each passage of the dermal papilla cells to identify changes in the dermal papilla cells with prolonged culture.

이하, 비한정적인 실시예를 통하여 본 발명을 더욱 상세하게 설명한다.Hereinafter, the present invention will be described in more detail with reference to non-limiting examples.

실시예 1: 모유두의 분리Example 1 Isolation of Breast Milk

DP 세포의 분리 및 배양은 기존의 방법(Horne, 등 J Embryol Exp Morph, 97, 111-124 (1986))에 따라 진행하였다. 남성형탈모를 갖는 5 환자에서 모발이식 수술시 공여부로 얻는 후두부 모발 조직에서 시료를 얻었다. 상기 시료를 즉시 Dulbecco's modified Eagle's medium (DMEM; Gibco BRL, Gaithersburg, MD, USA)에 넣었다. 각 성장기(anagen) 모발을 해부현미경(steromicroscope) 하에서 모유두를 분리하였다.Isolation and cultivation of DP cells was performed according to conventional methods (Horne, et al. J Embryol Exp Morph, 97, 111-124 (1986)). Samples were obtained from the posterior head hair tissue obtained as a donor during hair transplantation in 5 patients with androgenetic alopecia. The samples were immediately placed in Dulbecco's modified Eagle's medium (DMEM; Gibco BRL, Gaithersburg, MD, USA). Each anagen hair was separated from the dermal papilla under a microscopy.

실시예 2: 모유두, 표피초(dermal sheath (DS) 및 섬유아세포 배양Example 2: Breast tea, dermal sheath (DS) and fibroblast culture

동일조직샘플로부터 분리된 모유두의 외식편(explant)으로부터 DP 세포를 성장시켰다. 배양을 위한 조직을 penicillin (100 U/ml), streptomycin (100 ㎍/ml), L-glutamine (0.584 mg/ml), 및 20% 불활성화된 fetal calf serum (Gibco BRL)이 포함된 2ml의 DMEM을 갖는 다섯 35 mm 디시(7-10 DP explants/dish)에 넣고 5% CO_2, 37℃에서 배양하였다. 외식편들은 처음 5일간 관찰하지 않은 채로 두고, 이후부터는 3일마다 배지를 갈아주었다. 약 4주 후에 일차 배양에서 약 70% 충만(confluent) 될 때, DP 세포들을 0.25% 트립신 및 0.02% EDTA 용액으로 채취하고 단일-세포 현탁액으로 계대시켰다. 차후의 계대배양에는 1:4로 나누었다. 계대배양 후에는 세포를 10% 불활성화된 fetal calf serum를 갖는 DMEM으로 바꾸어 유지하였다. 각 계대에 대해 1/4의 DP 세포를 채취하고 cDNA 마이크로어레이를 위해 보관하였다. 모낭주위 결합초(dermal sheath; DS) 세포 및 모낭사이(interfollicular) 표피 섬유아세포들을 DP 세포와 유사하게 배양하였다.DP cells were grown from explants of dermal papilla isolated from homologous tissue samples. Tissue for culture was 2 ml of DMEM containing penicillin (100 U / ml), streptomycin (100 μg / ml), L-glutamine (0.584 mg / ml), and 20% inactivated fetal calf serum (Gibco BRL). Five 35 mm dishes (7-10 DP explants / dish) were prepared and incubated at 5% CO _2, 37 ° C. Explants were left unobserved for the first five days, after which the medium was changed every three days. When about 70% confluent in the primary culture after about 4 weeks, DP cells were harvested with 0.25% trypsin and 0.02% EDTA solution and passaged into single-cell suspension. Subsequent passages were divided by 1: 4. After subculture, cells were maintained in DMEM with 10% inactivated fetal calf serum. 1/4 DP cells were harvested for each passage and stored for cDNA microarrays. Peripheral follicular sheath (DS) cells and interfollicular epidermal fibroblasts were cultured similarly to DP cells.

실시예 3: 전체 RNA 추출Example 3: Total RNA Extraction

전체 RNA는 변형된 acid phenol 방법을 사용하여 모유두 및 섬유아세포로부터 추출하였다. 간단하게 설명하면, 성장배지를 제거하고 세포를 Trizol (Life Technologies)로 용해시켰다. 용해액을 1/10 볼륨의 1-bromo-3-cholopropane을 첨가하여 추출하였다. 수용층을 새 튜브에 모아서 isopropanol로 침전시켰다. 75% ethanol 세척 후, 펠렛을 공기-건조시키고, DEPC-처리된 물로 재부유 시키고, UV spectrometer (DU530, Beckman, USA)를 사용한 A260/A280 측정에 의해 정량하였다. 양을 측정하기 위해, 1 μg 의 전체 변성 1.0 % 포름알데히드 아가로스 젤 상에 로딩하고 전기영동 하였다.Total RNA was extracted from dermal papilla and fibroblasts using modified acid phenol method. Briefly, growth medium was removed and cells were lysed with Trizol (Life Technologies). The lysate was extracted by adding 1/10 volume of 1-bromo-3-cholopropane. The aqueous layer was collected in a new tube and precipitated with isopropanol. After 75% ethanol washing, the pellets were air-dried, resuspended with DEPC-treated water and quantified by A260 / A280 measurements using a UV spectrometer (DU530, Beckman, USA). To determine the amount, 1 μg of total denatured 1.0% formaldehyde agarose gel was loaded and electrophoresed.

실시예 4: mRNA 분리Example 4 mRNA Separation

mRNA는 Dynabead mRNA 정제 키트(Dynal)를 사용하여 전체 RNA로부터 분리하였다. DP 세포로부터 얻은 전체 RNA를 65에 2 분간 가열하고, Dynabeads Oligo (dT)를 새 튜브속으로 분산시키고 상층액을 30초간 자석 내에 튜브를 위치시킨 후 제거하였다. Dynabeads 펠렛을 동량의 전체 RNA로 바인딩 버퍼 속에서 재부유한 후 상온에서 3분간 튜브를 회전하여 가열한 전체 RNA와 잘 혼합하였다. 튜브를 30초간 자석위에 위치시키고 상층액을 제거하였다. 그 펠렛을 버퍼로 2회 세척하고 용리(elution) 버퍼로 재부유한 후 65 ℃에서 2 분간 가열하였다. 그 펠렛을 자석위에 위치한 후 상등액을 새 PCR 튜브로 회수하였다.mRNA was isolated from total RNA using the Dynabead mRNA Purification Kit (Dynal). Total RNA from DP cells was heated to 65 for 2 minutes, Dynabeads Oligo (dT) was dispersed into a new tube and the supernatant was removed after placing the tube in a magnet for 30 seconds. The Dynabeads pellet was resuspended in the binding buffer with the same amount of total RNA, and then mixed well with the heated total RNA by rotating the tube for 3 minutes at room temperature. The tube was placed on the magnet for 30 seconds and the supernatant was removed. The pellet was washed twice with buffer, resuspended in elution buffer and heated at 65 ° C. for 2 minutes. The pellet was placed on a magnet and the supernatant was recovered into a new PCR tube.

실시예 5: in vitro 전사방법을 사용한 RNA 증폭Example 5: RNA amplification using in vitro transcription

세포의 조기 계대 특히 일차 외식(explanted)된 디쉬에서 충분한 RNA를 얻는 것은 어렵기 때문에 모든 mRNA 샘플들은 T7 RNA polymerase를 이용하는 RNA 증폭법으로 일회 증폭 후 사용하였다. RNA 증폭은, mRNA를 T7-Oligo (dT) 프라이머로 혼합하고 70 ℃에서 10분간 가열하였다. 첫 가닥 cDNA를 제조하기 위해, 혼합물을 빠르게 얼음에서 냉각하고, First strand buffer, DTT 및 dNTP를 첨가하였다. 그 혼합물을 42℃에서 2분간 예열하고, Superscript II reverse transcriptase를 첨가하고 42 ℃에서 50 분간 정치하였다. 그 첫 가닥 cDNA에 second strand buffer, dNTP, E. coli DNA ligase, E. coli DNA polymerase, E. coli RNase H를 첨가하였다. 그 혼합물을 16 ℃에서 2 시간 정치한 후, T4 DNA polymerase를 첨가하고 16 ℃에서 5 분간 정치하였다. Second stranded cDNA를 페놀:크로로포름으로 추출하고 ammonium acetate 및 100 % ethanol로 -20 ℃에서 침전시켰다. 그 RNA를 4 ℃, 13,000 rpm에서 30 분간 원심분리하여 회수하였고, 그 RNA 펠렛을 75 % ethanol로 세척 후 공기중에서 건조한 펠렛을 DEPC-처리한 물로 녹였다. 이들 이중 가닥 cDNAs를 Ampliscribe T7 Transcription Kit를 사용한 in vitro 전사에 의해 증폭하였다. T7 특이적 프로모터로 주형 DNA를 리니어한 이중 가닥 cDNA를 T7 반응버퍼, ATP, CTP, GTP, UTP, 및 DTT와 혼합하였다. 그 혼합물을 37 ℃에서 5 분간 예열 후 Ampliscribe T7 RNA polymerase를 첨가하고 37 ℃에서 2.5시간 정치하였다. 그 후 RNA 산물을 TRI reagent solution (Gibco-BRL Grand Island, NY, USA) 및 1-Bromo-3-chloropropane과 혼합하고, 4 ℃에서 30분간 원심분리하였다. 그 상등액을 새 튜브로 옮기고 동량의 isopropanol을 첨가하였다. RNA를 침전시키기 위해, 그 혼합물을 -20 ℃에서 적어도 3시간 보존하고 4 ℃에서 30분간 원심분리하였다 그 펠렛을 75 % ethanol로 세척하고 DEPC-처리 물에 녹였다. 증폭된 RNA를 정제하기 위해 그 RNA를 Microcon-30로 여과하였다. 그 샘플을 컬럼에 로딩하고 13,000 rpm에서 7분간 회전하였다. 이 단계를 3회 반복 후 약 20 ㎕ 의 샘플을 회수하였다. 그 증폭된 RNA (aRNA)를 새 튜브로 회수하고 질과 양을 UV 분광기로 체크하였다.All mRNA samples were used after amplification by RNA amplification using T7 RNA polymerase, because it is difficult to obtain sufficient RNA from early passage of cells, especially in primary explanted dishes. RNA amplification was performed by mixing mRNA with T7-Oligo (dT) primer and heating at 70 ° C. for 10 minutes. To prepare the first strand cDNA, the mixture was cooled rapidly on ice and First strand buffer, DTT and dNTP were added. The mixture was preheated at 42 ° C. for 2 minutes, Superscript II reverse transcriptase was added and left at 42 ° C. for 50 minutes. To the first strand cDNA was added a second strand buffer, dNTP, E. coli DNA ligase, E. coli DNA polymerase, and E. coli RNase H. The mixture was allowed to stand at 16 ° C. for 2 hours, and then T4 DNA polymerase was added and left at 16 ° C. for 5 minutes. Second stranded cDNA was extracted with phenol: chloroform and precipitated at −20 ° C. with ammonium acetate and 100% ethanol. The RNA was recovered by centrifugation at 13,000 rpm for 30 minutes at 4 ° C. The RNA pellet was washed with 75% ethanol, and the dried pellets in air were dissolved in DEPC-treated water. These double stranded cDNAs were amplified by in vitro transcription using Ampliscribe T7 Transcription Kit. Double stranded cDNAs linear with template DNA with a T7 specific promoter were mixed with T7 reaction buffer, ATP, CTP, GTP, UTP, and DTT. The mixture was preheated at 37 ° C. for 5 minutes, and then Ampliscribe T7 RNA polymerase was added and left at 37 ° C. for 2.5 hours. The RNA product was then mixed with TRI reagent solution (Gibco-BRL Grand Island, NY, USA) and 1-Bromo-3-chloropropane and centrifuged at 4 ° C. for 30 minutes. The supernatant was transferred to a new tube and the same amount of isopropanol was added. To precipitate RNA, the mixture was stored for at least 3 hours at −20 ° C. and centrifuged at 4 ° C. for 30 minutes. The pellet was washed with 75% ethanol and dissolved in DEPC-treated water. The RNA was filtered through Microcon-30 to purify the amplified RNA. The sample was loaded into the column and spun for 7 minutes at 13,000 rpm. After repeating this step three times, about 20 μl of the sample was recovered. The amplified RNA (aRNA) was recovered in a new tube and quality and quantity checked by UV spectroscopy.

실시예 6: aRNA으로부터 형광 DNA 프로브의 제조Example 6: Preparation of Fluorescent DNA Probe from aRNA

형광표지된 프로브를 Khan J 등(Proc. Natl. Acad. Sci. USA, 96:13264-13269 (1999))의 방법에 따라 제조하였다. 섬유아세포를 녹색형광을 내는 Cy-3 dCTP로 표지하고 모유두의 각 계대를 적색형광인 Cy-5 dCTP(Amersham)로 표지하였다. 각 역전사반응에는 4 ㎍ aRNA 및 1 ㎍ random hexamer를 포함하였다. 역전사 후에 샘플을 각 1.0 ㎕ 의 1.5 M 수산화나트륨 및 30 mM EDTA로 65℃에서 10분간 처리한 후, 468 ㎕ 의 TE buffer (pH 7.4)를 사용하여 중화하였다. Microcon 30 (Millipore, USA)를 사용하여, 프로브를 정제하고 농축하였다. Cy-3 및 Cy-5 형광 표지된 프로브를 mg/ml poly A blocker (Amersham) 및 0.5 mg/ml yeast tRNA (Life Technologies)와 3 X SSC, 0.1 % SDS에서 최종 부피 25 ㎕로 혼합하였다.Fluorescently labeled probes were prepared according to the method of Khan J et al. (Proc. Natl. Acad. Sci. USA, 96: 13264-13269 (1999)). Fibroblasts were labeled with green fluorescent Cy-3 dCTP and each passage of the dermal papilla was labeled with red fluorescent Cy-5 dCTP (Amersham). Each reverse transcription included 4 μg aRNA and 1 μg random hexamer. After reverse transcription, samples were treated with 1.0 μl of 1.5 M sodium hydroxide and 30 mM EDTA for 10 minutes at 65 ° C., and then neutralized with 468 μl of TE buffer (pH 7.4). Using Microcon 30 (Millipore, USA), the probe was purified and concentrated. Cy-3 and Cy-5 fluorescent labeled probes were mixed with mg / ml poly A blocker (Amersham) and 0.5 mg / ml yeast tRNA (Life Technologies) at a final volume of 25 μl in 3 × SSC, 0.1% SDS.

실시예 7: 마이크로어레이 교잡화Example 7: Microarray Hybridization

실험실에서 직접 제작한 인간 4.7K cDNA 칩을 사용하였다. 그것은 모발(hair)-특이적 cDNA 마이크로어레이이고, 모유두 cDNA 라이브러리로부터 분리된 4,700 cDNA 클론을 가지고 있다. 본 발명에서는 실험의 각 세트 당 다섯 슬라이드 및 총 25 슬라이드가 사용되었다. Amino-silane 코팅된 슬라이드(CMT-GAPS^TM, Corning)를 코플린 자(coplin jar) 3.5 ＞ SSC, 0.1% SDS, 10 mg/ml BSA에서 50℃에서 20분간 프리-하이브리다이즈하고 물과 이소프로판올에 담구어 세척하고 원심분리를 사용하여 건조하였다. 그 제조된 프로브를 95-100℃에서 2분간 가열하여 변성하고 커버 슬라이드를 갖는 어레이 위에 놓았다. 교잡화는 50℃ 수조 내의 CMT-Hybridization 챔버(Corning)에서 20 시간동안 행하였다. 어레이를 일차세척 버퍼(0.1 ＞ SSC/0.1 % SSC)로 상온에서 5분간 세척하고, 다시 이차세척 버퍼(0.1 ＞ SSC)로 5분간 2회 세척한 후 원심분리를 사용하여 건조하였다.A human 4.7K cDNA chip manufactured in the laboratory was used. It is a hair-specific cDNA microarray and has 4,700 cDNA clones isolated from the dermal papilla cDNA library. Five slides and a total of 25 slides were used for each set of experiments in the present invention. Amino-silane-coated slides (CMT-GAPS ^™ , Corning) were pre-hybridized at 50 ° C. for 20 minutes in a Coplin jar 3.5> SSC, 0.1% SDS, 10 mg / ml BSA and water and isopropanol Dipped in, washed and dried using centrifugation. The prepared probe was denatured by heating at 95-100 ° C. for 2 minutes and placed on an array with a cover slide. Hybridization was carried out for 20 hours in a CMT-Hybridization chamber (Corning) in a 50 ℃ water bath. The array was washed for 5 minutes at room temperature with primary wash buffer (0.1> SSC / 0.1% SSC), again washed twice with secondary wash buffer (0.1> SSC) for 5 minutes and dried using centrifugation.

실시예 8: 스캐닝 및 이미지 분석Example 8: Scanning and Image Analysis

고정화된 타겟에서 발생하는 형광 강도를 공초점 레이저 스캐너인 Scanarray 4000(GSI Lumonics, USA)를 사용하여 측정하였다. 두 형광 이미지들(Cy-3 및 Cy-5)을 각각 스캐닝하고 겹쳐진 색 이미지들을 섬유아세포 형광강도를 그린 채널로 모유두세포의 형광강도를 레드 채널로 산술적으로 할당하여 형성하였고, 데이터를 GenePix 소프트웨어(version 3.0, Axon Instruments, Inc)을 사용하여 분석하였다. 각 어레이 결과를 두가지 다른 형광색소를 가지고 표지와 검출에서 다른 효율을 위해 조정하기 위해 LOWESS 알고리즘에 의한 within-print-tip 군(Yang, Y. H., 등 Nucleic Acids Res. 30, e15. (2002))에 따라 표준화하였다. 노이즈 시그널을 제거하기 위해, 시그널 형광강도와 배경의 형광강도의 비가 1.4이하를 보이는 스팟들을 표준화과정에서 제거하였다.Fluorescence intensity occurring at the immobilized target was measured using a confocal laser scanner Scanarray 4000 (GSI Lumonics, USA). Scanning two fluorescent images (Cy-3 and Cy-5), respectively, and overlapping color images were formed by arithmetically assigning the fluorescence intensity of the dermal papilla cells to the red channel with the fibroblast fluorescence intensity green channel, and the data were generated using GenePix software ( version 3.0, Axon Instruments, Inc). Each array results with two different fluorophores in the within-print-tip group (Yang, YH, et al. Nucleic Acids Res. 30, e15. (2002)) by the LOWESS algorithm to adjust for different efficiencies in labeling and detection. Standardized accordingly. In order to remove the noise signal, spots showing a ratio of signal fluorescence intensity and background fluorescence intensity of 1.4 or less were removed in the standardization process.

실시예 9: 크러스터링 및 트리 뷰(tree view)를 위한 데이터 분석Example 9: Data Analysis for Clustering and Tree View

모든 25 교잡화 반응에서에서 얻은 로그 비(log ratio)값들을 표 파일(tabular file)로 변화(merge)하였다. 관리되지 않은(unsupervised) 클러스터링 분석을 위해, 샘플의 70% 이상 존재하고 샘플에서 표준편차가 0.8이하인 어레이 성분만을 선택하였다. 계통 크러스터링(Hierachical clustering)을 유전자들 및 샘플 모두에 적용하였다. 분석은 M. Eisen에 의해 기재된 웹상 소프트웨어 Cluster 및 TreeView(Eisen MB, 등 Proc. Natl. Acad. Sci. USA, 95:14863-8 (1998))를 사용하여 수행하였다.The log ratio values obtained in all 25 hybridization reactions were merged into tabular files. For unsupervised clustering analysis, only array components were selected that were present in at least 70% of the sample and had a standard deviation of 0.8 or less in the sample. Hierarchical clustering was applied to both genes and samples. Analyzes were performed using the Web-based software Cluster and TreeView (Eisen MB, et al. Proc. Natl. Acad. Sci. USA, 95: 14863-8 (1998)) described by M. Eisen.

이상 실시예의 결과를 간단히 설명하면 다음과 같다.The result of the above embodiment is briefly described as follows.

DP특정 유전자를 스크리닝하기 위해, 본 발명자들은 DP cDNA 라이브러리로부터 4,700의 cDNA 클론을 포함한 실험실에서 제작한 cDNA microarray로 테스트했다.To screen for DP specific genes, we tested with a laboratory-made cDNA microarray containing 4,700 cDNA clones from the DP cDNA library.

내부 대조군으로 하우스키핑 유전자, 베타-actin, 및 글리셀알데히드 3－인산 탈수소산소(GAPDH)를 같은 어레이 상에 포함하였다.Housekeeping genes, beta-actin, and glycelaldehyde 3-phosphate dehydrogenated oxygen (GAPDH) were included on the same array as internal controls.

microarray는 형광 색소로 표지된 cDNA 프로브에 의해 교잡했다.The microarrays were hybridized by fluorescent dye labeled cDNA probes.

프로브는 배양된 DP세포 제4의 계대까지 및 섬유아세포로부터 온 aRNA로 제조되었다.Probes were prepared with aRNA from cultured DP cells up to the fourth passage and from fibroblasts.

형광 타겟을 엄격한 조건하에서 microarray상의 클론에 교잡하게 했다.Fluorescent targets were hybridized to clones on the microarray under stringent conditions.

통합된 타겟의 레이저 익사이테이션은 특정의 스펙트럼을 가지는 발광을 내고, 그것을 공초점 레이저 스캐너를 사용해 측정된다. GenePix 소프트웨어를 이용하여 스캐너(Scanarray 4000)로부터 얻은 모노크롬 이미지를 임포트하고 슈도(pseudo)-색을 입혔다.The laser excitation of the integrated target emits light with a specific spectrum, which is measured using a confocal laser scanner. GenePix software was used to import monochrome images obtained from the scanner (Scanarray 4000) and pseudo-colored.

하이브리다이제이션 결과의 칼라 이미지는 Cy-3 형광성의 이미지를 그린 및 Cy-5 형광성 이미지를 레드로 표시하고, 두 개의 칼라 이미지를 합병하여 제조하였다.Color images of the hybridization results were prepared by displaying Cy-3 fluorescent images green and Cy-5 fluorescent images red, and merging the two color images.

그러한 하이브리다이제이션의 예는 도 1에 나타났다. 도 1은 DP에서 유래한 cDNA 프로브는 Cy-5 dUTP(적색), 섬유아세포로부터 온 cDNA 프로브는 Cy-3 dUTP(녹색)으로 표지시켰다.An example of such hybridization is shown in FIG. 1. 1 is labeled with cDNA probe derived from DP Cy-5 dUTP (red), cDNA probe from fibroblasts is Cy-3 dUTP (green).

그림에서 적색 및 녹색 형광 스팟은 DP 및 섬유아세포에서 각각 상대적으로 높은 발현을 나타내는 유전자를 의미하고 노란색 스팟은 두 종류의 세포에서 발현에 차이가 없는 유전자를 의미한다.In the figure, red and green fluorescence spots represent genes with relatively high expression in DP and fibroblasts, respectively, and yellow spots mean genes with no difference in expression in both cell types.

각 어레이 결과는 LOWESS 알고리즘에 의해 within-print-tip 그룹에 따라 표준화(normalization)하였고, 그 스팟 시그널 대 백그라운드 강도 비가 1.4 이하인 것을 노이즈 시그널로 간주하여 그것들을 여과했다.Each array result was normalized according to the within-print-tip group by the LOWESS algorithm, and they were filtered by considering that the spot signal to background intensity ratio was 1.4 or less.

표준화 및 여과 과정 후에 각 데이터세트는 플롯 그래프를 만들어 표준화단계를 체크하였다. 그리고 데이터는 Cluster 프로그램에 가져온 비율만을 갖는다.After normalization and filtration, each dataset was plotted to check the standardization step. And the data has only the ratio imported to the cluster program.

25 쌍의 DP 및 섬유아세포 샘플 중에서 적어도 2쌍이 두 배 이상의 차이를 보이는 유전자들을 더 크러스터링 분석을 위해서 선택하였다.Among the 25 pairs of DP and fibroblast samples, at least two pairs of genes with more than twofold differences were selected for further clustering analysis.

이렇게 선택된 클론은 883 유전자들이고 크러스터링 결과 플롯은 도 2에 나타났다.The clones thus selected were 883 genes and the clustering results plot is shown in FIG. 2.

관리되지 않는 크러스터링 결과는 DP 및 섬유아세포의 유전자 형질 발현 차이를 차별화하기 용이하게 만들었다.Unmanaged clustering results made it easier to differentiate gene expression differences in DP and fibroblasts.

또한 그것은 계대 전(DP0)의 일차 외식체 DP세포의 유전자 형질 발현 프로화일이 계대 후의 것과 매우 차이가 있고, 계대 1(DP1)의 유전자 발현 프로화일은 계대 4(DP4)와 큰 차이가 없다는 것을 또한 보여준다.It also shows that the gene expression profile of primary explant DP cells before passage (DP0) is very different from that after passage, and that the gene expression profile of passage 1 (DP1) is not significantly different from passage 4 (DP4). .

크러스터링 분석에 의해, 차별적으로 발현된 유전자를 DP 세포 내에서 일반적으로 과잉 발현된 유전자들(도 3 및 표 1), DP0에서는 아니고, DP1에서 DP4에서만 업-레굴레이트된 유전자들 (도 4), DP0에서만 과잉 발현된 유전자들(표 2)로 나누었다.By clustering analysis, differentially expressed genes are generally overexpressed in DP cells (FIG. 3 and Table 1), genes up-regulated only in DP1 but not in DP0 (FIG. 4). , Genes overexpressed only in DP0 (Table 2).

섬유아세포와 비교하여 일반적으로 DP에서 과잉 발현된 유전자들(33 유전자)은 레티노익산 수용체, dickkopf 3, 이미디어트 얼리 리스폰스 3, 프로테오글리칸 1, 트랜스포밍 성장 인자 2(TGF-2), 인타루킨 11의 수용체, 시스테인 리치 단백질 2, 카드헤린(cadherin) 2, 메탈로프로테이즈 19, 트로포마이오신, transgelin 2, 라이실 옥시데이즈-like 2, 카트리지 링킹 단백질 1, 인히빈 베타 A 및 옥시토신 수용체를 포함한다.Compared to fibroblasts, genes generally overexpressed in DP (33 genes) are retinoic acid receptor, dickkopf 3, early early response 3, proteoglycan 1, transforming growth factor 2 (TGF-2), intaleukin. 11 receptors, cysteine rich protein 2, cadherin 2, metalloprotease 19, tropomyosin, transgelin 2, lysyl oxidase-like 2, cartridge linking protein 1, inhibin beta A and oxytocin receptors Include.

DP0 및 섬유아세포와 비교하여 DP1에서 DP4에 이르는 계대된 DP세포에서 업-레귤레이트된 유전자들(47 유전자들)에는 콜라겐 IV형, netrin 4, 미오신경쇄 키나제,α평활근 엑틴, 칼포닌 1, 액티닌(actinin)α1, 골아세포 특정인자 2(OSF2), 감수 분열 체크포인트 조절 인자, 결합 조직 성장 인자(CTGF), 앤지오텐진 수용체 1 및 asporin을 포함한다.Up-regulated genes (47 genes) in passaged DP cells ranging from DP1 to DP4 compared to DP0 and fibroblasts include collagen type IV, netrin 4, myosin light chain kinase, α smooth muscle actin, calponin 1, fluid Actininα1, osteoblast specific factor 2 (OSF2), meiosis checkpoint regulator, connective tissue growth factor (CTGF), angiotensin receptor 1 and asporin.

다른 세포와 비교해 DP0에서 과잉발현된 27개의 유전자들은 콜라겐형 VII, DNA 바인딩 3 저해제, 종양 엔도쎄이얼 마커 6, 포크헤드 박스 M1, 프로테오리피드 단백질 2, pleiotrophin, 알도-케토·리덕테이즈 B1, syndecan 3, 메탈로프로테이즈 3 조직 인히비터(TIMP-3), sprouty 호모로지 4, 트란스케토레이즈, FXYD 도메인 5, CD9 및 SH3-도메인을 포함한다.27 genes overexpressed in DP0 compared to other cells were collagen type VII, DNA binding 3 inhibitor, tumor endothelial marker 6, forkhead box M1, proteolipid protein 2, pleiotrophin, aldo-keto-reductase B1 , syndecan 3, metalloprotease 3 tissue inhibitors (TIMP-3), sprouty homology 4, transketases, FXYD domain 5, CD9 and SH3-domains.

실시예 10: 노던 블럿Example 10: Northern Blot

마이크로어레이 결과를 노던 교잡화로 확인하였다. RNA를 DP, DS, 및 섬유아세포로부터 얻어 각 10 ㎍의 전체 RNA를 1.0% 아가로스/포름알데히드 젤상에서 분리하고 나이론 막(Hybond N+; Amersham Biosciences, Burminghamshire, UK)으로 트랜스퍼하였다. 막들을 랜덩 프라임된 [³²P]dCTP-표지된 cDNA 프로브로 ExpressHyb 교잡화 용액(Clontech, Palo Alto, CA)내에서 65℃에서 1시간 교잡하였다. 세척 후 막들을 하이 스트린전시에서 세척하고 X-레이 필름에 노출하였다.Microarray results were confirmed by Northern hybridization. RNA was obtained from DP, DS, and fibroblasts and each 10 μg of total RNA was isolated on 1.0% agarose / formaldehyde gel and transferred to a nylon membrane (Hybond N +; Amersham Biosciences, Burminghamshire, UK). Membranes were hybridized for 1 hour at 65 ° C. in ExpressHyb hybridization solution (Clontech, Palo Alto, Calif.) With a ranuncin primed [ ³² P] dCTP-labeled cDNA probe. After washing the membranes were washed in high stringency and exposed to X-ray film.

microarray 결과를 확인하기 위해서, 노던 하이브리다이제이션을 수행하였다(도 6 및 7). 20개의 차별적으로 발현되는 유전자들을 DP, DS 및 섬유아세포에서 비교하였다. 노던 블럿 결과들은 microarray 데이터와 우수한 상관관계가 있었다. 두 다른 세포인 DP 및 섬유아세포 사이 안에서 DS세포의 유전자 형질 발현 프로화일을 보인다는 것은 흥미롭다.In order to confirm the microarray results, northern hybridization was performed (FIGS. 6 and 7). Twenty differentially expressed genes were compared in DP, DS and fibroblasts. Northern blot results correlated well with microarray data. It is interesting to show the gene expression profile of DS cells between two different cells, DP and fibroblasts.

섬유아세포에 비해 모유두세포에서 업-레귤레이트되는 유전자Gene up-regulated in dermal papilla cells compared to fibroblasts 진뱅크Gin bank IDID 유전자 명Gene name DP0DP0 DP 1~4 AverageDP 1 ~ 4 Average DP1DP1 DP2DP2 DP3DP3 DP4DP4 NM_016152.2NM_016152.2 retinoic acid receptor, betaretinoic acid receptor, beta 4.244.24 2.82.8 3.23.2 3.73.7 4.14.1 33 NM_013253.1NM_013253.1 dickkopf homolog 3dickkopf homolog 3 3.683.68 3.283.28 3.53.5 4.24.2 4.54.5 4.24.2 NM_000903.1NM_000903.1 NAD(P)H dehydrogenase,quinone 1NAD (P) H dehydrogenase, quinone 1 3.473.47 1.821.82 2.22.2 2.12.1 2.42.4 2.42.4 NM_052815.1NM_052815.1 immediate early response 3immediate early response 3 3.23.2 2.772.77 3.13.1 3.63.6 3.63.6 3.63.6 NM_002727.1NM_002727.1 proteoglycan 1proteoglycan 1 2.852.85 2.212.21 2.52.5 2.22.2 3.53.5 2.82.8 NM_003238.1NM_003238.1 TGFB2TGFB2 2.812.81 3.663.66 4.44.4 4.64.6 5.15.1 4.24.2 NM_006622.1NM_006622.1 serum-inducible kinaseserum-inducible kinase 2.782.78 2.642.64 3.33.3 2.72.7 3.83.8 3.43.4 NM_004512.2NM_004512.2 interleukin 11 receptor, alphainterleukin 11 receptor, alpha 2.692.69 5.035.03 5.25.2 8.18.1 5.85.8 6.26.2 NM_001312.1NM_001312.1 cysteine-rich protein 2cysteine-rich protein 2 2.562.56 1.91.9 2.22.2 2.12.1 33 2.22.2 NM_007173.2NM_007173.2 protease, serine, 23protease, serine, 23 2.552.55 2.912.91 3.13.1 44 3.33.3 4.24.2 NM_000995.2NM_000995.2 ribosomal protein L34ribosomal protein L34 2.332.33 2.622.62 3.23.2 3.43.4 44 2.42.4 NM_001792.2NM_001792.2 cadherin 2, type 1cadherin 2, type 1 2.332.33 3.743.74 6.46.4 4.94.9 3.83.8 3.63.6 NM_033274.1NM_033274.1 disintegrin and metalloproteinase,19disintegrin and metalloproteinases, 19 2.32.3 2.772.77 3.53.5 3.93.9 3.63.6 2.82.8 NM_006516.1NM_006516.1 solute carrier family 2, member 1solute carrier family 2, member 1 2.32.3 2.342.34 2.52.5 3.53.5 2.52.5 3.23.2 NM_024427.1NM_024427.1 Mus musculus tropomyosin 1αMus musculus tropomyosin 1α 2.32.3 2.982.98 3.23.2 3.93.9 3.33.3 4.44.4 NM_004137.1NM_004137.1 calcium-activated channelcalcium-activated channel 2.282.28 4.764.76 4.64.6 7.17.1 6.56.5 5.65.6 NM_080630.1NM_080630.1 collagen, type XI, alpha 1collagen, type XI, alpha 1 2.152.15 6.176.17 6.26.2 8.68.6 88 8.28.2 NM_000366.2NM_000366.2 tropomyosin 1 - alphatropomyosin 1-alpha 2.052.05 2.942.94 2.72.7 3.93.9 3.83.8 4.34.3 NM_020992.2NM_020992.2 PDZ and LIM domain 1 (elfin)PDZ and LIM domain 1 (elfin) 2.012.01 2.612.61 2.92.9 3.23.2 3.63.6 3.33.3 NM_134034.1NM_134034.1 Mus musculus AW011752Mus musculus AW011752 1.961.96 2.072.07 2.82.8 2.72.7 2.32.3 2.52.5 NM_005245.1NM_005245.1 FAT tumor suppressor homolog 1FAT tumor suppressor homolog 1 1.911.91 1.861.86 2.32.3 2.52.5 2.52.5 22 NM_003564.1NM_003564.1 transgelin 2transgelin 2 1.891.89 1.431.43 1.41.4 1.61.6 2.32.3 1.81.8 NM_002318.1NM_002318.1 lysyl oxidase-like 2lysyl oxidase-like 2 1.851.85 3.533.53 3.53.5 5.15.1 4.34.3 4.94.9 NM_001884.1NM_001884.1 cartilage linking protein 1cartilage linking protein 1 1.831.83 3.183.18 4.54.5 3.73.7 44 3.73.7 NM_002192.1NM_002192.1 inhibin, beta Ainhibin, beta A 1.741.74 2.022.02 2.32.3 2.62.6 2.72.7 2.52.5 NM_000916.2NM_000916.2 oxytocin receptoroxytocin receptor 1.71.7 2.092.09 2.42.4 2.92.9 2.82.8 2.42.4 NM_022542.1NM_022542.1 Rattus norvegicus rhoB geneRattus norvegicus rhoB gene 1.71.7 2.332.33 2.52.5 2.82.8 3.43.4 2.92.9 AK021874AK021874 cDNA FLJ11812 fiscDNA FLJ11812 fis 3.133.13 3.673.67 5.15.1 4.14.1 5.85.8 3.33.3 AY027862AY027862 mammalian ependymin-RP1mammalian ependymin-RP1 2.432.43 3.223.22 3.63.6 4.44.4 3.93.9 4.24.2 AA806104AA806104 oc25c05.s1 cDNA, 3' endoc25c05.s1 cDNA, 3 'end 2.432.43 2.262.26 2.42.4 2.62.6 3.33.3 3.13.1 AK056751AK056751 cDNA FLJ32189 fiscDNA FLJ32189 fis 2.062.06 2.192.19 2.52.5 2.52.5 3.33.3 2.62.6 AV652424AV652424 AV652424 cDNA, 3' endAV652424 cDNA, 3 'end 1.991.99 2.092.09 2.42.4 2.62.6 2.82.8 2.82.8 AK026116AK026116 cDNA: FLJ22463 fiscDNA: FLJ22463 fis 1.831.83 1.721.72 22 1.91.9 2.52.5 2.22.2 A1231A1231 2.962.96 3.23.2 3.83.8 4.24.2 44 44

DP0 세포에서 특이적인 유전자Specific genes in DP0 cells 진뱅크Gin bank IDID 유전자 명Gene name DP0DP0 DP1~4 AverageDP1 ~ 4 Average DP1DP1 DP2DP2 DP3DP3 DP4DP4 NM_000094.2NM_000094.2 collagen, type VII, alpha 1(서열목록1)collagen, type VII, alpha 1 (SEQ ID NO: 1) 2.662.66 1.41.4 1.91.9 2.12.1 1.491.49 1.551.55 NM_002167.1NM_002167.1 inhibitor of DNA binding 3(서열목록2)inhibitor of DNA binding 3 (SEQ ID NO: 2) 2.632.63 1.541.54 1.31.3 2.22.2 2.332.33 1.891.89 NM_022748.6NM_022748.6 tumor endothelial marker 6 (서열목록3)tumor endothelial marker 6 (SEQ ID NO: 3) 2.542.54 1.451.45 1.91.9 1.81.8 1.711.71 1.821.82 NM_003981.1NM_003981.1 protein regulator of cytokinesis 1(서열목록4)protein regulator of cytokinesis 1 (SEQ ID NO: 4) 2.482.48 0.90.9 0.80.8 0.80.8 1.411.41 1.471.47 NM_006818.2NM_006818.2 ALL1-fused gene from ch 1q (서열목록5)ALL1-fused gene from ch 1q (SEQ ID NO: 5) 2.452.45 1.741.74 2.12.1 2.22.2 2.42.4 1.971.97 NM_021953.1NM_021953.1 forkhead box M1 (서열목록6)forkhead box M1 (SEQ ID NO: 6) 2.342.34 0.790.79 1One 0.70.7 1.161.16 1One NM_018131.2NM_018131.2 hypothetical protein FLJ10540 (서열목록7)hypothetical protein FLJ10540 (SEQ ID NO: 7) 2.272.27 0.870.87 1One 0.70.7 1.391.39 1.21.2 NM_003878.1NM_003878.1 gamma-glutamyl hydrolase(서열목록8)gamma-glutamyl hydrolase (SEQ ID NO: 8) 2.252.25 1.111.11 1.41.4 1.21.2 1.441.44 1.571.57 NM_024056.1NM_024056.1 hypothetical protein MGC5576 (서열목록9)hypothetical protein MGC5576 (SEQ ID NO: 9) 2.142.14 1.631.63 1.81.8 2.12.1 2.042.04 2.162.16 NM_002668.1NM_002668.1 proteolipid protein 2 (서열목록10)proteolipid protein 2 (SEQ ID NO: 10) 2.132.13 1.371.37 1.51.5 1.51.5 2.032.03 1.791.79 NM_031476.1NM_031476.1 hypothetical protein DKFZp434B044(서열목록11)hypothetical protein DKFZp434B044 (SEQ ID NO: 11) 2.122.12 1.381.38 2.12.1 2.32.3 1.411.41 1.071.07 NM_001634.3NM_001634.3 S-adenosylmethionine decarboxylase 1 (서열목록12)S-adenosylmethionine decarboxylase 1 (SEQ ID NO: 12) 2.12.1 0.80.8 1One 0.90.9 1.11.1 0.960.96 NM_002825.2NM_002825.2 pleiotrophin (서열목록13)pleiotrophin (SEQ ID NO: 13) 2.12.1 1.021.02 1.41.4 1.21.2 1.481.48 1.051.05 NM_001628.1NM_001628.1 aldo-keto reductase 1, B1(서열목록14)aldo-keto reductase 1, B1 (SEQ ID NO: 14) 2.072.07 0.690.69 1One 0.90.9 0.810.81 0.810.81 NM_014654.1NM_014654.1 syndecan 3 (서열목록15)syndecan 3 (SEQ ID NO: 15) 2.012.01 1.131.13 1.41.4 1.71.7 1.21.2 1.381.38 NM_000362.3NM_000362.3 tissue inhibitor of metalloproteinase 3(서열목록16)tissue inhibitor of metalloproteinase 3 (SEQ ID NO: 16) 2.012.01 0.990.99 1.31.3 1.21.2 1.251.25 1.231.23 NM_030964.1NM_030964.1 sprouty homolog 4 (서열목록17)sprouty homolog 4 (SEQ ID NO: 17) 1.991.99 0.430.43 0.50.5 0.60.6 0.440.44 0.590.59 NM_001064.1NM_001064.1 transketolase(서열목록18)transketolase (SEQ ID NO: 18) 1.991.99 0.990.99 1.31.3 1.21.2 1.031.03 1.381.38 NM_014164.3NM_014164.3 FXYD domain, 5 (서열목록19)FXYD domain, 5 (SEQ ID NO: 19) 1.981.98 1.271.27 1.51.5 1.61.6 1.641.64 1.611.61 NM_001769.2NM_001769.2 CD9 antigen (p24)(서열목록20)CD9 antigen (p24) (SEQ ID NO: 20) 1.861.86 1.11.1 1.61.6 1.41.4 1.241.24 1.31.3 NM_002818.1NM_002818.1 proteasome ,activator subunit 2(서열목록21)proteasome, activator subunit 2 (SEQ ID NO: 21) 1.841.84 1.221.22 1.51.5 1.51.5 1.431.43 1.631.63 NM_024745.1NM_024745.1 hypothetical protein FLJ22009(서열목록22)hypothetical protein FLJ22009 (SEQ ID NO: 22) 1.811.81 0.90.9 1.21.2 0.90.9 1.351.35 0.970.97 NM_014521.1NM_014521.1 SH3-domain binding protein 4 (서열목록23)SH3-domain binding protein 4 (SEQ ID NO: 23) 1.811.81 1.321.32 1.61.6 1.51.5 1.931.93 1.511.51 AL080156AL080156 cDNA DKFZp434J214 (서열목록24)cDNA DKFZp434J214 (SEQ ID NO: 24) 2.412.41 1.031.03 1.21.2 1.11.1 1.41.4 1.531.53 AK026116AK026116 cDNA: FLJ22463 fis(서열목록25)cDNA: FLJ22463 fis (SEQ ID NO: 25) 1.831.83 1.721.72 22 1.91.9 2.542.54 2.162.16 HC2613HC2613 1.881.88 0.680.68 0.90.9 0.80.8 0.910.91 0.790.79 K982-5K982-5 1.861.86 1.331.33 1.71.7 1.91.9 1.41.4 1.651.65

상기 표2에서 알 수 있는 DP0에서 특이적으로 발현되는 유전자들은 모낭형성능력을 가지므로, 배양 초기의 모낭형성 능력을 지니고 있을 때 특이적으로 발현되는 유전자를 알게되면 이를 이용하여 오래 배양된 세포에 어떤 조건을 첨가하였을 때 다시 모낭형성 능력을 가지는 세포 여부를 알아낼 수 있는 좋은 표식이 될 수 있다.Since genes specifically expressed in DP0 as shown in Table 2 have hair follicle forming ability, when the gene is specifically expressed when it has hair follicle forming ability in the early stage of culture, it is used for long-cultured cells. When certain conditions are added, it can be a good marker to find out whether the cells have hair follicle forming ability again.

도 1은 마이크로어레이 검출의 결과를 보여주는 사진. 전체 마이크로어레이는 인간의 DP세포 cDNA 라이브러리에 유래한 4,700 유전자를 포함하고, 섬유아세포로부터의 RNA 샘플은 Cy3-dUTP(녹색 형광)으로 표지하였고, DP는 Cy5-dUTP(붉은 형광)으로 표지하였다.1 is a photograph showing the results of microarray detection. The whole microarray contained 4,700 genes derived from human DP cell cDNA libraries, RNA samples from fibroblasts were labeled with Cy3-dUTP (green fluorescence) and DP was labeled with Cy5-dUTP (red fluorescence).

도 2는 25쌍의 모유두 및 섬유아세포의 마이크로어레이 결과의 선택된 886 유전자의 크러스터된 데이터 세트의 트리 뷰 이미지를 보여주는 사진이다. 최초 4자리 숫자는 샘플 식별 번호이다. DP0는 계대 전에 일차 배양된 DP세포를 의미하고, DP1에서 DP4는 각 계대배양으로부터 얻은 DP세포를 의미한다. 수직축은 세포주에 횡축은 유전자에 해당된다.FIG. 2 is a photograph showing a tree view image of a clustered data set of selected 886 genes from microarray results of 25 pairs of papillary and fibroblasts. The first four digits are the sample identification number. DP0 refers to DP cells cultured before passage, and DP1 to DP4 refer to DP cells obtained from each passage. The vertical axis corresponds to the cell line and the horizontal axis corresponds to the gene.

도 3은 인간 모유두 세포에서 일반적으로 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.3 is a photograph showing a tree view image of clusters of genes generally up-regulated in human dermal papilla cells.

도 4는 계대 후 인간 모유두 세포에서 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.4 is a photograph showing a tree view image of clusters of up-regulated genes in human dermal papilla cells after passage.

도 5는 섬유아세포에서 업-레귤레이트된 유전자들의 크러스터의 트리 뷰 이미지를 보여주는 사진이다.Figure 5 is a photograph showing a tree view image of the cluster of up-regulated genes in fibroblasts.

도 6은 모유두 특이적 유전자들의 노던 하이브리다이제이션을 보여주는 사진이다.Figure 6 is a photograph showing the northern hybridization of dermal papilla specific genes.

도 7은 섬유아세포 특이적 유전자들의 노던 하이브리다이제이션을 보여주는 사진이다.7 is a photograph showing northern hybridization of fibroblast specific genes.

<110> Kyungpook National University Industrial Collaboration Foundation <120> Genes with activity forming hair follicle <160> 49 <170> KopatentIn 1.71 <210> 1 <211> 9272 <212> DNA <213> Homo sapiens <400> 1 gggctggagg ggcgctgggc tcggacctgc caaggccacc gcagggggga gcaagggaca 60 gaggcggggg tcctagctga cggcttttac tgcctaggat gacgctgcgg cttctggtgg 120 ccgcgctctg cgccgggatc ctggcagagg cgccccgagt gcgagcccag cacagggaga 180 gagtgacctg cacgcgcctt tacgccgctg acattgtgtt cttactggat ggctcctcat 240 ccattggccg cagcaatttc cgcgaggtcc gcagctttct cgaagggctg gtgctgcctt 300 tctctggagc agccagtgca cagggtgtgc gctttgccac agtgcagtac agcgatgacc 360 cacggacaga gttcggcctg gatgcacttg gctctggggg tgatgtgatc cgcgccatcc 420 gtgagcttag ctacaagggg ggcaacactc gcacaggggc tgcaattctc catgtggctg 480 accatgtctt cctgccccag ctggcccgac ctggtgtccc caaggtctgc atcctgatca 540 cagacgggaa gtcccaggac ctggtggaca cagctgccca aaggctgaag gggcaggggg 600 tcaagctatt tgctgtgggg atcaagaatg ctgaccctga ggagctgaag cgagttgcct 660 cacagccaac ctccgacttc ttcttcttcg tcaatgactt cagcatcttg aggacactac 720 tgcccctcgt ttcccggaga gtgtgcacga ctgctggtgg cgtgcctgtg acccgacctc 780 cggatgactc gacctctgct ccacgagacc tggtgctgtc tgagccaagc agccaatcct 840 tgagagtaca gtggacagcg gccagtggcc ctgtgactgg ctacaaggtc cagtacactc 900 ctctgacggg gctgggacag ccactgccga gtgagcggca ggaggtgaac gtcccagctg 960 gtgagaccag tgtgcggctg cggggtctcc ggccactgac cgagtaccaa gtgactgtga 1020 ttgccctcta cgccaacagc atcggggagg ctgtgagcgg gacagctcgg accactgccc 1080 tagaagggcc ggaactgacc atccagaata ccacagccca cagcctcctg gtggcctggc 1140 ggagtgtgcc aggtgccact ggctaccgtg tgacatggcg ggtcctcagt ggtgggccca 1200 cacagcagca ggagctgggc cctgggcagg gttcagtgtt gctgcgtgac ttggagcctg 1260 gcacggacta tgaggtgacc gtgagcaccc tatttggccg cagtgtgggg cccgccactt 1320 ccctgatggc tcgcactgac gcttctgttg agcagaccct gcgcccggtc atcctgggcc 1380 ccacatccat cctcctttcc tggaacttgg tgcctgaggc ccgtggctac cggttggaat 1440 ggcggcgtga gactggcttg gagccaccgc agaaggtggt actgccctct gatgtgaccc 1500 gctaccagtt ggatgggctg cagccgggca ctgagtaccg cctcacactc tacactctgc 1560 tggagggcca cgaggtggcc acccctgcaa ccgtggttcc cactggacca gagctgcctg 1620 tgagccctgt aacagacctg caagccaccg agctgcccgg gcagcgggtg cgagtgtcct 1680 ggagcccagt ccctggtgcc acccagtacc gcatcattgt gcgcagcacc cagggggttg 1740 agcggaccct ggtgcttcct gggagtcaga cagcattcga cttggatgac gttcaggctg 1800 ggcttagcta cactgtgcgg gtgtctgctc gagtgggtcc ccgtgagggc agtgccagtg 1860 tcctcactgt ccgccgggag ccggaaactc cacttgctgt tccagggctg cgggttgtgg 1920 tgtcagatgc aacgcgagtg agggtggcct ggggacccgt ccctggagcc agtggatttc 1980 ggattagctg gagcacaggc agtggtccgg agtccagcca gacactgccc ccagactcta 2040 ctgccacaga catcacaggg ctgcagcctg gaaccaccta ccaggtggct gtgtcggtac 2100 tgcgaggcag agaggagggc cctgctgcag tcatcgtggc tcgaacggac ccactgggcc 2160 cagtgaggac ggtccatgtg actcaggcca gcagctcatc tgtcaccatt acctggacca 2220 gggttcctgg cgccacagga tacagggttt cctggcactc agcccacggc ccagagaaat 2280 cccagttggt ttctggggag gccacggtgg ctgagctgga tggactggag ccagatactg 2340 agtatacggt gcatgtgagg gcccatgtgg ctggcgtgga tgggccccct gcctctgtgg 2400 ttgtgaggac tgcccctgag cctgtgggtc gtgtgtcgag gctgcagatc ctcaatgctt 2460 ccagcgacgt tctacggatc acctgggtag gggtcactgg agccacagct tacagactgg 2520 cctggggccg gagtgaaggc ggccccatga ggcaccagat actcccagga aacacagact 2580 ctgcagagat ccggggtctc gaaggtggag tcagctactc agtgcgagtg actgcacttg 2640 tcggggaccg cgagggcaca cctgtctcca ttgttgtcac tacgccgcct gaggctccgc 2700 cagccctggg gacgcttcac gtggtgcagc gcggggagca ctcgctgagg ctgcgctggg 2760 agccggtgcc cagagcgcag ggcttccttc tgcactggca acctgagggt ggccaggaac 2820 agtcccgggt cctggggccc gagctcagca gctatcacct ggacgggctg gagccagcga 2880 cacagtaccg cgtgaggctg agtgtcctag ggccggctgg agaagggccc tctgcagagg 2940 tgactgcgcg cactgagtca cctcgtgttc caagcattga actacgtgtg gtggacacct 3000 cgatcgactc ggtgactttg gcctggactc cagtgtccag ggcatccagc tacatcctat 3060 cctggcggcc actcagaggc cctggccagg aagtgcctgg gtccccgcag acacttccag 3120 ggatctcaag ctcccagcgg gtgacagggc tagagcctgg cgtctcttac atcttctccc 3180 tgacgcctgt cctggatggt gtgcggggtc ctgaggcatc tgtcacacag acgccagtgt 3240 gcccccgtgg cctggcggat gtggtgttcc taccacatgc cactcaagac aatgctcacc 3300 gtgcggaggc tacgaggagg gtcctggagc gtctggtgtt ggcacttggg cctcttgggc 3360 cacaggcagt tcaggttggc ctgctgtctt acagtcatcg gccctcccca ctgttcccac 3420 tgaatggctc ccatgacctt ggcattatct tgcaaaggat ccgtgacatg ccctacatgg 3480 acccaagtgg gaacaacctg ggcacagccg tggtcacagc tcacagatac atgttggcac 3540 cagatgctcc tgggcgccgc cagcacgtac caggggtgat ggttctgcta gtggatgaac 3600 ccttgagagg tgacatattc agccccatcc gtgaggccca ggcttctggg cttaatgtgg 3660 tgatgttggg aatggctgga gcggacccag agcagctgcg tcgcttggcg ccgggtatgg 3720 actctgtcca gaccttcttc gccgtggatg atgggccaag cctggaccag gcagtcagtg 3780 gtctggccac agccctgtgt caggcatcct tcactactca gccccggcca gagccctgcc 3840 cagtgtattg tccaaagggc cagaaggggg aacctggaga gatgggcctg agaggacaag 3900 ttgggcctcc tggcgaccct ggcctcccgg gcaggaccgg tgctcccggc ccccaggggc 3960 cccctggaag tgccactgcc aagggcgaga ggggcttccc tggagcagat gggcgtccag 4020 gcagccctgg ccgcgccggg aatcctggga cccctggagc ccctggccta aagggctctc 4080 cagggttgcc tggccctcgt ggggacccgg gagagcgagg acctcgaggc ccaaaggggg 4140 agccgggggc tcccggacaa gtcatcggag gtgaaggacc tgggcttcct gggcggaaag 4200 gggaccctgg accatcgggc ccccctggac ctcgtggacc actgggggac ccaggacccc 4260 gtggcccccc agggcttcct ggaacagcca tgaagggtga caaaggcgat cgtggggagc 4320 ggggtccccc tggaccaggt gaaggtggca ttgctcctgg ggagcctggg ctgccgggtc 4380 ttcccggaag ccctggaccc caaggccccg ttggcccccc tggaaagaaa ggagaaaaag 4440 gtgactctga ggatggagct ccaggcctcc caggacaacc tgggtctccg ggtgagcagg 4500 gcccacgggg acctcctgga gctattggcc ccaaaggtga ccggggcttt ccagggcccc 4560 tgggtgaggc tggagagaag ggcgaacgtg gacccccagg cccagcggga tcccgggggc 4620 tgccaggggt tgctggacgt cctggagcca agggtcctga agggccacca ggacccactg 4680 gccgccaagg agagaagggg gagcctggtc gccctgggga ccctgcagtg gtgggacctg 4740 ctgttgctgg acccaaagga gaaaagggag atgtggggcc cgctgggccc agaggagcta 4800 ccggagtcca aggggaacgg ggcccacccg gcttggttct tcctggagac cctggcccca 4860 agggagaccc tggagaccgg ggtcccattg gccttactgg cagagcagga cccccaggtg 4920 actcagggcc tcctggagag aagggagacc ctgggcggcc tggcccccca ggacctgttg 4980 gcccccgagg acgagatggt gaagttggag agaaaggtga cgagggtcct ccgggtgacc 5040 cgggtttgcc tggaaaagca ggcgagcgtg gccttcgggg ggcacctgga gttcgggggc 5100 ctgtgggtga aaagggagac cagggagatc ctggagagga tggacgaaat ggcagccctg 5160 gatcatctgg acccaagggt gaccgtgggg agccgggtcc cccaggaccc ccgggacggc 5220 tggtagacac aggacctgga gccagagaga agggagagcc tggggaccgc ggacaagagg 5280 gtcctcgagg gcccaagggt gatcctggcc tccctggagc ccctggggaa aggggcattg 5340 aagggtttcg gggaccccca ggcccacagg gggacccagg tgtccgaggc ccagcaggag 5400 aaaagggtga ccggggtccc cctgggctgg atggccggag cggactggat gggaaaccag 5460 gagccgctgg gccctctggg ccgaatggtg ctgcaggcaa agctggggac ccagggagag 5520 acgggcttcc aggcctccgt ggagaacaag gcctccctgg cccctctggt ccccctggat 5580 taccgggaaa gccaggcgag gatgggaaac ctggcctgaa tggaaaaaac ggagaacctg 5640 gggaccctgg agaagacggg aggaagggag agaaaggaga ttcaggcgcc tctgggagag 5700 aaggtcgtga tggccccaag ggtgagcgtg gagctcctgg tatccttgga ccccaggggc 5760 ctccaggcct cccagggcca gtgggccctc ctggccaggg ttttcctggt gtcccaggag 5820 gcacgggccc caagggtgac cgtggggaga ctggatccaa aggggagcag ggcctccctg 5880 gagagcgtgg cctgcgagga gagcctggaa gtgtgccgaa tgtggatcgg ttgctggaaa 5940 ctgctggcat caaggcatct gccctgcggg agatcgtgga gacctgggat gagagctctg 6000 gtagcttcct gcctgtgccc gaacggcgtc gaggccccaa gggggactca ggcgaacagg 6060 gccccccagg caaggagggc cccatcggct ttcctggaga acgcgggctg aagggcgacc 6120 gtggagaccc tggccctcag gggccacctg gtctggccct tggggagagg ggcccccccg 6180 ggccttccgg ccttgccggg gagcctggaa agcctggtat tcccgggctc ccaggcaggg 6240 ctgggggtgt gggagaggca ggaaggccag gagagagggg agaacgggga gagaaaggag 6300 aacgtggaga acagggcaga gatggccctc ctggactccc tggaacccct gggccccccg 6360 gaccccctgg ccccaaggtg tctgtggatg agccaggtcc tggactctct ggagaacagg 6420 gaccccctgg actcaagggt gctaaggggg agccgggcag caatggtgac caaggtccca 6480 aaggagacag gggtgtgcca ggcatcaaag gagaccgggg agagcctgga ccgaggggtc 6540 aggacggcaa cccgggtcta ccaggagagc gtggtatggc tgggcctgaa gggaagccgg 6600 gtctgcaggg tccaagaggc ccccctggcc cagtgggtgg tcatggagac cctggaccac 6660 ctggtgcccc gggtcttgct ggccctgcag gaccccaagg accttctggc ctgaaggggg 6720 agcctggaga gacaggacct ccaggacggg gcctgactgg acctactgga gctgtgggac 6780 ttcctggacc ccccggccct tcaggccttg tgggtccaca ggggtctcca ggtttgcctg 6840 gacaagtggg ggagacaggg aagccgggag ccccaggtcg agatggtgcc agtggaaaag 6900 atggagacag agggagccct ggtgtgccag ggtcaccagg tctgcctggc cctgtcggac 6960 ctaaaggaga acctggcccc acgggggccc ctggacaggc tgtggtcggg ctccctggag 7020 caaagggaga gaagggagcc cctggaggcc ttgctggaga cctggtgggt gagccgggag 7080 ccaaaggtga ccgaggactg ccagggccgc gaggcgagaa gggtgaagct ggccgtgcag 7140 gggagcccgg agaccctggg gaagatggtc agaaaggggc tccaggaccc aaaggtttca 7200 agggtgaccc aggagtcggg gtcccgggct cccctgggcc tcctggccct ccaggtgtga 7260 agggagatct gggcctccct ggcctgcccg gtgctcctgg tgttgttggg ttcccgggtc 7320 agacaggccc tcgaggagag atgggtcagc caggccctag tggagagcgg ggtctggcag 7380 gccccccagg gagagaagga atcccaggac ccctggggcc acctggacca ccggggtcag 7440 tgggaccacc tggggcctct ggactcaaag gagacaaggg agaccctgga gtagggctgc 7500 ctgggccccg aggcgagcgt ggggagccag gcatccgggg tgaagatggc cgccccggcc 7560 aggagggacc ccgaggactc acggggcccc ctggcagcag gggagagcgt ggggagaagg 7620 gtgatgttgg gagtgcagga ctaaagggtg acaagggaga ctcagctgtg atcctggggc 7680 ctccaggccc acggggtgcc aagggggaca tgggtgaacg agggcctcgg ggcttggatg 7740 gtgacaaagg acctcgggga gacaatgggg accctggtga caagggcagc aagggagagc 7800 ctggtgacaa gggctcagcc gggttgccag gactgcgtgg actcctggga ccccagggtc 7860 aacctggtgc agcagggatc cctggtgacc cgggatcccc aggaaaggat ggagtgcctg 7920 gtatccgagg agaaaaagga gatgttggct tcatgggtcc ccggggcctc aagggtgaac 7980 ggggagtgaa gggagcctgt ggccttgatg gagagaaggg agacaaggga gaagctggtc 8040 ccccaggccg ccccgggctg gcaggacaca aaggagagat gggggagcct ggtgtgccgg 8100 gccagtcggg ggcccctggc aaggagggcc tgatcggtcc caagggtgac cgaggctttg 8160 acgggcagcc aggccccaag ggtgaccagg gcgagaaagg ggagcgggga accccaggaa 8220 ttgggggctt cccaggcccc agtggaaatg atggctctgc tggtccccca gggccacctg 8280 gcagtgttgg tcccagaggc cccgaaggac ttcagggcca gaagggtgag cgaggtcccc 8340 ccggagagag agtggtgggg gctcctgggg tccctggagc tcctggcgag agaggggagc 8400 aggggcggcc agggcctgcc ggtcctcgag gcgagaaggg agaagctgca ctgacggagg 8460 atgacatccg gggctttgtg cgccaagaga tgagtcagca ctgtgcctgc cagggccagt 8520 tcatcgcatc tggatcacga cccctcccta gttatgctgc agacactgcc ggctcccagc 8580 tccatgctgt gcctgtgctc cgcgtctctc atgcagagga ggaagagcgg gtaccccctg 8640 aggatgatga gtactctgaa tactccgagt attctgtgga ggagtaccag gaccctgaag 8700 ctccttggga tagtgatgac ccctgttccc tgccactgga tgagggctcc tgcactgcct 8760 acaccctgcg ctggtaccat cgggctgtga caggcagcac agaggcctgt cacccttttg 8820 tctatggtgg ctgtggaggg aatgccaacc gttttgggac ccgtgaggcc tgcgagcgcc 8880 gctgcccacc ccgggtggtc cagagccagg ggacaggtac tgcccaggac tgaggcccag 8940 ataatgagct gagattcagc atcccctgga ggagtcgggg tctcagcaga accccactgt 9000 ccctcccctt ggtgctagag gcttgtgtgc acgtgagcgt gcgagtgcac gtccgttatt 9060 tcagtgactt ggtcccgtgg gtctagcctt cccccctgtg gacaaacccc cattgtggct 9120 cctgccaccc tggcagatga ctcactgtgg gggggtggct gtgggcagtg agcggatgtg 9180 actggcgtct gacccgcccc ttgacccaag cctgtgatga catggtgctg attctggggg 9240 gcattaaagc tgctgtttta aaaggcaaaa aa 9272 <210> 2 <211> 1203 <212> DNA <213> Homo sapiens <400> 2 gatctggggt gctgccagga aaaagcaaat tctggaagtt aatggttttg agtgattttt 60 aaatccttgc tggcggagag gcccgcctct ccccggtatc agcgcttcct cattctttga 120 atccgcggct ccgcggtctt cggcgtcaga ccagccggag gaagcctgtt tgcaatttaa 180 gcgggctgtg aacgcccagg gccggcgggg gcggggccga ggcgggccat tttgaataaa 240 gaggcgtgcc ttccaggcag gctctataag tgaccgccgc ggcgagcgtg cgcgcgttgc 300 aggtcactgt agcggacttc ttttggtttt ctttctcttt ggggcacctc tggactcact 360 ccccagcatg aaggcgctga gcccggtgcg cggctgctac gaggcggtgt gctgcctgtc 420 ggaacgcagt ctggccatcg cccggggccg agggaagggc ccggcagctg aggagccgct 480 gagcttgctg gacgacatga accactgcta ctcccgcctg cgggaactgg tacccggagt 540 cccgagaggc actcagctta gccaggtgga aatcctacag cgcgtcatcg actacattct 600 cgacctgcag gtagtcctgg ccgagccagc ccctggaccc cctgatggcc cccaccttcc 660 catccagaca gccgagctcg ctccggaact tgtcatctcc aacgacaaaa ggagcttttg 720 ccactgactc ggccgtgtcc tgacacctcc agaacgcagg tgctggcgcc cgttctgcct 780 gggaccccgg gaacctctcc tgccggaagc cggacggcag ggatgggccc caacttcgcc 840 ctgcccactt gacttcacca aatcccttcc tggagactaa acctggtgct caggagcgaa 900 ggactgtgaa cttgtagcct gaagagccag agctagctct ggccaccagc tgggcgacgt 960 caccctgctc ccaccccacc cccaagttct aaggtctttt cagagcgtgg aggtgtggaa 1020 ggagtggctg ctctccaaac tatgccaagg cggcggcaga gctggtcttc tggtctcctt 1080 ggagaaaggt tctgttgccc tgatttatga actctataat agagtatata ggttttgtac 1140 cttttttaca ggaaggtgac tttctgtaac aatgcgatgt atattaaact ttttataaaa 1200 gtt 1203 <210> 3 <211> 6702 <212> DNA <213> Homo sapiens <400> 3 ccccgactag cccgacagtc cccgactagc ccgacagccc cagcaggatc tgcatcgtca 60 tcgagccggc ccagcttctg aagggagatg tcatggtgaa atgctaccac aagaaatacc 120 gctcggccac ccgtgacgtc attttccgcc tgcagtttca cactggggct gtgcagggct 180 acgggctggt gtttgggaag gaggatctgg acaatgccag caaagatgac cgttttcctg 240 actatgggaa ggttgaatta gtcttctctg ccacgcctga gaagattcaa gggtccgaac 300 acttgtacaa cgaccacggt gtgattgtgg actacaacac aacagaccca ctgatacgct 360 gggactcgta cgagaacctc agtgcagatg gagaagtgct acacacgcag ggccctgtcg 420 atggcagcct ttacgcgaag gtgaggaaga aaagctcctc ggatcctggc atcccaggtg 480 gcccccaggc aatcccggcc accaacagcc cagaccacag tgaccacacc ttgtctgtca 540 gcagtgactc cggccactct acagcctctg ccaggacgga taagacggaa gagcgcctgg 600 ccccaggaac caggaggggc ctgagtgccc aggagaaggc agagttggac cagctgctca 660 gtggctttgg cctggaagat cctggaagct ccctcaagga aatgactgat gctcgaagca 720 agtacagtgg gacccgccac gtggtgccag cccaggttca cgtgaatgga gacgctgctc 780 tgaaggatcg ggagacagac attctggatg acgagatgcc ccaccacgac ctgcacagtg 840 tggacagcct tgggaccctg tcctcctcgg aagggcctca gtcggcccac ctgggtccct 900 tcacctgcca caagagcagc cagaactcac tcctatctga cggttttggc agcaacgttg 960 gtgaagatcc gcagggcacc ctcgttccgg acctgggcct tggcatggac ggcccctatg 1020 agcgggagcg gacttttggg agtcgagagc ccaagcagcc ccagcccctg ctgagaaagc 1080 cctcagtgtc cgcccagatg caggcctatg ggcagagcag ctactccaca cagacctggg 1140 tgcgccagca gcagatggtt gtagctcacc agtatagctt cgccccagat ggggaggccc 1200 ggctggtgag ccgctgccct gcagacaatc ctggcctcgt ccaggcccag cccagagtgc 1260 cactcacccc cacccgaggg accagcagta gggtggctgt ccagaggggt gtaggcagtg 1320 ggccacatcc ccctgacaca cagcagccct ctcccagcaa agcgttcaaa cccaggtttc 1380 caggagacca ggttgtgaat ggagccggcc cagagctgag cacaggcccc tccccaggct 1440 cgcccaccct ggacatcgac cagtccatcg agcagctcaa caggctgatc ctggagctgg 1500 atcccacctt cgagcccatc cctacccaca tgaacgccct cggtagccag gccaatggct 1560 ctgtgtctcc agacagcgtg ggaggtgggc tccgggcaag cagcaggctg cctgacacag 1620 gagagggccc cagcagggcc accgggcggc aaggctcctc tgctgaacag cccctgggcg 1680 ggagactcag gaagctgagc ctggggcagt acgacaacga tgctgggggg cagctgccct 1740 tctccaaatg tgcatgggga aaggctggtg tggactatgc cccaaacctg ccgccattcc 1800 cctcaccagc ggacgtcaaa gagacgatga cccctggcta tccccaggac ctcgatatta 1860 tcgatggcag aattttaagt agcaaggagt ccatgtgttc aactccagca tttcctgtgt 1920 ctccagagac accgtatgtg aaaacagcgc tgcgccatcc tccgttcagc ccacctgagc 1980 ccccgctgag cagcccagcc agtcagcaca aaggaggacg tgaaccacga agctgccctg 2040 agacgctcac tcacgctgtg gggatgtcag agagccccat cggacccaaa tccacgatgc 2100 tccgggctga tgcgtcctcg acgccctcct ttcagcaggc ttttgcttct tcctgcacca 2160 tttccagcaa cggccctggg cagaggagag agagctcctc ttctgcagaa cgccagtggg 2220 tggagagcag ccccaagccc atggtttccc tgctggggag cggccggccc accggaagtc 2280 ccctcagcgc tgagttctcc ggtaccagga aggactcccc agtgctgtcc tgcttcccgc 2340 cgtcagagct ccaggctcct ttccacagcc atgagctgtc cctagcagag ccaccggact 2400 ccctggcgcc tcccagcagc caggccttcc tgggcttcgg caccgcccca gtgggaagtg 2460 gccttccgcc cgaggaggac ctgggggcct tgctggccaa ttctcatgga gcgtcaccga 2520 cccccagcat cccgctgaca gcgacagggg ctgccgacaa tggcttcctg tcccacaact 2580 ttctcacggt ggcgcctgga cacagcagcc accacagtcc aggcctgcag ggccagggtg 2640 tgaccctgcc cgggcagcca cccctccctg agaagaagcg ggcctcggag ggggatcgtt 2700 ctttgggctc agtctctccc tcctccagtg gcttctccag cccgcacagc gggagcacca 2760 tcagtatccc cttcccaaat gtccttcccg acttttccaa ggcttcagaa gcggcctcac 2820 ctctgccaga tagtccaggt gataaacttg tgatcgtgaa atttgttcaa gacacttcca 2880 agttctggta caaggcggat atttcaagag aacaagccat cgccatgttg aaggacaagg 2940 agccgggctc attcattgtt cgagacagcc attccttccg aggggcctat ggcctggcca 3000 tgaaggtggc cacgccccca ccttcagtcc tgcagctgaa caagaaagct ggagatttgg 3060 ccaatgaact cgtccggcac tttttgatcg agtgtacccc gaagggagtg cggttgaaag 3120 ggtgctcgaa tgaaccatat ttcgggagcc tgacggcctt ggtgtgccag cattccatca 3180 cgcccttggc cttgccgtgc aagctgctta tcccagagag agatccattg gaggaaatag 3240 cagaaagttc tccccagacg gcagccaatt cagcagctga gctgttgaag cagggggcag 3300 cctgcaacgt gtggtacttg aactctgtgg agatggagtc cctcaccggc caccaggcga 3360 tccagaaggc cctgagcatc accctggtcc aggagcctcc acctgtgtcc acagttgtgc 3420 acttcaaggt gtcagcccag ggcatcaccc tgacagacaa tcagaggaag ctcttcttcc 3480 ggaggcatta ccccgtgaac agtgtgattt tctgtgcctt ggacccacaa gacaggaagt 3540 ggatcaaaga tggcccttcc tcaaaagtct ttggatttgt ggcccggaag cagggcagtg 3600 ccacggataa tgtgtgccac ctgtttgcag agcatgaccc tgagcagcct gccagtgcca 3660 ttgtcaactt cgtatcaaag gtcatgattg gttccccaaa gaaggtctga gaactcccct 3720 ccctccctgg acccaccgat gcctctcgaa gccctggaga cagccgttgg gtgagggtgg 3780 ggcccccact ttttaccaaa ctagtaaacc tgacattcca ggcccatgag gggaaagagg 3840 atcttccagc tctgcaaaaa caagaacaaa caacatcacc gtgaattggc ctttcctgaa 3900 agtgacttat ctgacacatc tctgtagcca catgcttttt gggtagaaga agctgggcat 3960 gggtgcaccc caccccctag ggtccccatg ggaaagggac atgcaaggaa acagcacaga 4020 acacgaggtg gtccccatgt ccctggcaca ctagcattcc gggggatgag gaatccccag 4080 cccttgaggc agaggtgccg agtgactgcc atgcttcgcc cgtccgcatg ggcgcttctg 4140 tccagctgca cccgaggccg ggggtttccc tcacctcggt cttcccaaga tggagatgct 4200 aacgaaactg agaagggggc gtatgtttga cgaaggtttg tgcaagtcag gcccttctgg 4260 aacacagcag ggcctacaac gaggggcctt tgcgatgggc tgtgaggatg ggggtggtgg 4320 gaagaattgg ccacgttaga gaccccatgc caccccacca tggtgagtgc tctgtgcctc 4380 ctgctcacct gtggtgagct gggcgagctg ggcgagctgg gcgagctggg ctggggagag 4440 cctgtgagga ccgagaggag aaatgagaag aaggaacaaa aatattattt ctatgtaatt 4500 tatattttac ttatgccaaa ttatttatga taatttgcca ttgctatact gtaccagtgt 4560 caaatgctgc agcctgccaa gctgtgattt tgtgaggctt gtccctatgt aggatgcacc 4620 gcaggcccct ggccactgaa agagtgtgca gtggactgtg ggtctcccat atgcggtgcc 4680 gcccaaaggt ggctttgcct caagcaacct accctgatgt tttactcatt ggaatgtttt 4740 tccccgattg tggatgactt cttttctgat ggagagagtc caggagggat ggaaaactcc 4800 tggatttaag ctcagcatcc cccacatggg cttttcgatc atcttcaggc ctgaagctgc 4860 acgacctgaa gttcgcctgc atttatcagc cctctttgtg ctgctccttg ccaccttggg 4920 gttcctgctg gggaccatgt gtggttgtgg catgtgtgag cagaagggag gatgaggaaa 4980 aagagaagaa accccggtac tgacaagctg tttttgagtg ccactgtttg ccatcatcta 5040 agccactgaa tcaagtgtat ttcaggctta tttcaacatt ccaatgccct ggttttcctg 5100 cttgaatctg ttcgtggtca aaggtttggg ggaatttgtg accctggaac atccccagag 5160 tgaaagatgg agctgggcca catcagaata aggccttggc cccatcctct cacagcctag 5220 gtgctctgca ggcatgctga ctgtcctgat tgcgatccag cccgaaattc cctcctctgc 5280 tttcaaaagt caaatccccc attcttaggc cacactggtg tcacaagctc ctgtcaggga 5340 gctggggttt gggaatgtgc tttgtgaact ctgctttaaa gtgaggggcc gaggaaaact 5400 tagaaacagg cagagttgga agcagccaaa tcacagtggg tgttgtgtgt gtgtgcgtgt 5460 gtgcatgcgt gcgtgtatgc gtgtgtgaaa gcaggtggac cattccactt tttagctcct 5520 attgatgcac caaaccaagt gcctcatttc tgtgccaaat gtttgccttg gtcgttgtgg 5580 acctccttct ctaacttgcg gtggcatgac tgtcaggagg tgctggcatt ttcagcagat 5640 cctcatgtgt tgaccctgat gtctttagca gaggcctcta gcatctcggt ttttcatcca 5700 ctgcaggaat gtggccacag ggagcagagg tttgtacttt ccccaagagg tcctcatcct 5760 gagacggtct ctacccatgt ttaacccaaa gagtgcaggc caggttcctt atccttctga 5820 tgaaggatga gagagctcat ttagaagtca gagcaaacta gggtctcagt attgagaaac 5880 gcagcctgcc agggaatcac agagacatcg gggtgcccgc gatggccctc atgaagccat 5940 gcctcgacgg cattcaggaa gccctgcaaa cgtgcttttt gaactcattg gccaggtgtg 6000 atttttacac aaggtaaacg tggtcaaggg catcggggaa tttgctccaa gcagatagct 6060 ccctctgagg aaccaaagga agcaagtttc cacgatttct gaagagctgg tataggaagt 6120 ttctttcttc cttttgtgtt acatgtgcat taaacagaac aagctgtgtg tcatcacaga 6180 ttgtactgtg ggctcagaaa ccgtgagaga gcccccaccg tggacaccgg ctctagggcc 6240 acaggaaaag gaacgtttcc aggcattttg tctccagggc tcccgctgga caggcacgta 6300 ctgccctggg gagtaaatgc ggagagttca cgaactgtgc ccaacgcatg ttatagccag 6360 ggtcctacta actactcagt aaaagaacgt attgttgtat tcctccagtg ttaagctata 6420 gccatgttaa aagtcactgt gcatttattc tcagcatcaa ataccttgta acgtcttctc 6480 tgccttgtta gtgcatattt ttacttttct gatactgtaa agaatatatc cagtatgtaa 6540 atgaatgttc tataaatctt ttgtatagtc attttctctg ctccttaaat atcatctcta 6600 ttcagagtat aataaaatta tgaacttggt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 6660 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 6702 <210> 4 <211> 3128 <212> DNA <213> Homo sapiens <400> 4 gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac 60 gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg 120 tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc 180 ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct 240 aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa 300 ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag 360 catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt 420 tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga 480 attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga 540 tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc 600 cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc 660 ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt 720 agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt 780 ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca 840 gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga 900 caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa 960 ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca 1020 aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg 1080 cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga 1140 aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca 1200 caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt 1260 tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga 1320 agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc 1380 acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt 1440 catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca 1500 ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc 1560 tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct 1620 gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg 1680 gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc 1740 ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa 1800 cctggagctc aacggcagca tcctgagtgg tgggtaccct ggctcggccc ccctccagcg 1860 caacttcagc attaattctg ttgccagcac ctattctgag tttgcgaagg atccgtccct 1920 ctctgacagt tccactgttg ggcttcagcg agaactttca aaggcttcca aatctgatgc 1980 tacttctgga atcctcaatt caaccaacat ccagtcctga gaagccctga tcagtcaacc 2040 agctgtggct tcctgtgcct agactggacc taattatatg ggggtgactt tagtttttct 2100 tcagcttagg cgtgcttgaa accttggcca ggttccatga ccatgggcct aacttaaaga 2160 tgtgaatgag tgttacagtt gaaagcccat cataggttta gtggtcctag gagacttggt 2220 tttgacttat atacatgaaa agtttatggc aagaagtgca aattttagca tatggggcct 2280 gacttctcta ccacataatt ctacttgctg aagcatgatc aaagcttgtt ttatttcacc 2340 actgtaggaa aatgattgac tatgcccatc cctgggggta attttggcat gtatacctgt 2400 aactagtaat taacatcttt tttgtttagg catgttcaat taatgctgta gctatcatag 2460 ctttgctctt acctgaagcc ttgtccccac cacacaggac agccttcctc ctgaagagaa 2520 tgtctttgtg tgtccgaagt tgagatggcc tgccctactg ccaaagaggt gacaggaagg 2580 ctgggagcag ctttgttaaa ttgtgttcag ttctgttaca cagtgcattg ccctttgttg 2640 ggggtatgca tgtatgaaca cacatgcttg tcggaacgct ttctcggcgt ttgtcccttg 2700 gctctcatct cccccattcc tgtgcctact ttgcctgagt tcttctaccc ccgcagttgc 2760 cagccacatt gggagtctgt ttgttccaat gggttgagct gtctttgtcg tggagatctg 2820 gaactttgca catgtcacta ctggggaggt gttcctgctc tagcttccac gatgaggcgc 2880 cctctttacc tatcctctca atcactactc ttcttgaagc actattattt attcttccgc 2940 tgtctgcctg cagcagtact actgtcaaca tagtgtaaat ggttctcaaa agcttaccag 3000 tgtggacttg gtgttagcca cgctgtttac tcatacagta cgtgtcctgt ttttaaaata 3060 tacaattatt cttaaaaata aattaaaatc tgtatactta catttcaaaa agaaaaaaaa 3120 aaaaaaaa 3128 <210> 5 <211> 1653 <212> DNA <213> Homo sapiens <400> 5 agtcagcacg ggggtgctgg aagagatcgg gaataatagc gcagaccaat gagcctaggg 60 agatgctttc atcgtctctc cttccctcaa gtgttctgga acctatcatt tgaattagcc 120 gagtcaggca ggagggggcg gggaatcctt ccgcccttct taggaggggc tgcattgcag 180 ggggagagtg aactgacaga ctcagtcact gaagagggaa aaggagtgag aagacaaagc 240 cgtcaaagcc ccaacagctt tgtatttctc cagcccggcg cagaccccgg agctcccgag 300 gcactccctc catctttgga acacgccagt aattgattga taacaggaag ctatgaggga 360 ccctgtgagt agccagtaca gttcctttct tttctggagg atgcccatcc cagaactgga 420 tctgtcggag ctggaaggcc tgggtctgtc agatacagcc acctacaagg tcaaagacag 480 cagcgttggc aaaatgatcg ggcaagcaac tgcagcagac caggagaaaa accctgaagg 540 tgatggcctc cttgagtaca gcaccttcaa cttctggaga gctcccattg ccagcatcca 600 ctccttcgaa ctggacttgc tctaaggcca agacttctct ctcccatcac cttgccctca 660 ttgtcttccc tctcaagccc cttcctttcc actcctttcc cattttaatc ttgttctctc 720 cctactgtgt tggtggtgct gatgaatctg ccagagttga gttctatgta tttatttatc 780 tatctgtcta ctccatttct ctcaaaagcc ctcaagtcac aaagtaaatg gttcaagcaa 840 tggagtactg ggtcacaggg attcctcctt tcccccccaa atattaactc cagaaactag 900 gcctgactgg ggacacctga gagtagtata gtagtgcaaa atggaagact gatttttgac 960 tctattataa tcagcttcag agattcctta aaccttccta atttcctgct ccagggcagt 1020 aaacacaaat atttcttcaa ggggtgatga aaacctcgga agttttaatt tgaggttatc 1080 tgctacgaaa cagtatttct aaaaggctaa agtgataagt ctcttgcttt tttttgatcc 1140 tgctcttata ttcttttttt tcctcagaga aatcaggagg gtagttagag gtataaaaca 1200 ggaggaaata ttatggaaaa tgaaaatagg gaaaataatt gaatcatttt agaagtagct 1260 aatttctttt ctcaaaagag tgtcccttct tcacacctac tcactttaca actttgctcc 1320 taactgtggg ttgaaaactc tagctaaaga aagttatcaa atcttaacat gcattcctac 1380 tattatgata gtttttaagg tttcaattca atcttctgaa cggcataagt cctattttag 1440 ccttacctcc tgcatttgca atacgtaata ctgatcagtg ggcacagttc ttcagctaca 1500 ttgagaccct gaaatgaaca attatattct gactcgacat cttgtcccca atccttccaa 1560 aaatattgat ggtgatttgt gctaccattt actcgtttat ttaataaaga cattcaatcc 1620 cagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1653 <210> 6 <211> 3527 <212> DNA <213> Homo sapiens <400> 6 actgaaagct ccggtgccag accccacccc cggccccggc ccgggacccc ctcccctccc 60 gggatccccc ggggttccca ccccgcccgc accgccgggg acccggccgg tccggcgcga 120 gcccccgtcc ggggccctgg ctcggccccc aggttggagg agcccggagc ccgccttcgg 180 agctacggcc taacggcggc ggcgactgca gtctggaggg tccacacttg tgattctcaa 240 tggagagtga aaacgcagat tcataatgaa aactagcccc cgtcggccac tgattctcaa 300 aagacggagg ctgccccttc ctgttcaaaa tgccccaagt gaaacatcag aggaggaacc 360 taagagatcc cctgcccaac aggagtctaa tcaagcagag gcctccaagg aagtggcaga 420 gtccaactct tgcaagtttc cagctgggat caagattatt aaccacccca ccatgcccaa 480 cacgcaagta gtggccatcc ccaacaatgc taatattcac agcatcatca cagcactgac 540 tgccaaggga aaagagagtg gcagtagtgg gcccaacaaa ttcatcctca tcagctgtgg 600 gggagcccca actcagcctc caggactccg gcctcaaacc caaaccagct atgatgccaa 660 aaggacagaa gtgaccctgg agaccttggg accaaaacct gcagctaggg atgtgaatct 720 tcctagacca cctggagccc tttgcgagca gaaacgggag acctgtgcag atggtgaggc 780 agcaggctgc actatcaaca atagcctatc caacatccag tggcttcgaa agatgagttc 840 tgatggactg ggctcccgca gcatcaagca agagatggag gaaaaggaga attgtcacct 900 ggagcagcga caggttaagg ttgaggagcc ttcgagacca tcagcgtcct ggcagaactc 960 tgtgtctgag cggccaccct actcttacat ggccatgata caattcgcca tcaacagcac 1020 tgagaggaag cgcatgactt tgaaagacat ctatacgtgg attgaggacc actttcccta 1080 ctttaagcac attgccaagc caggctggaa gaactccatc cgccacaacc tttccctgca 1140 cgacatgttt gtccgggaga cgtctgccaa tggcaaggtc tccttctgga ccattcaccc 1200 cagtgccaac cgctacttga cattggacca ggtgtttaag ccactggacc cagggtctcc 1260 acaattgccc gagcacttgg aatcacagca gaaacgaccg aatccagagc tccgccggaa 1320 catgaccatc aaaaccgaac tccccctggg cgcacggcgg aagatgaagc cactgctacc 1380 acgggtcagc tcatacctgg tacctatcca gttcccggtg aaccagtcac tggtgttgca 1440 gccctcggtg aaggtgccat tgcccctggc ggcttccctc atgagctcag agcttgcccg 1500 ccatagcaag cgagtccgca ttgcccccaa ggtgctgcta gctgaggagg ggatagctcc 1560 tctttcttct gcaggaccag ggaaagagga gaaactcctg tttggagaag ggttttctcc 1620 tttgcttcca gttcagacta tcaaggagga agaaatccag cctggggagg aaatgccaca 1680 cttagcgaga cccatcaaag tggagagccc tcccttggaa gagtggccct ccccggcccc 1740 atctttcaaa gaggaatcat ctcactcctg ggaggattcg tcccaatctc ccaccccaag 1800 acccaagaag tcctacagtg ggcttaggtc cccaacccgg tgtgtctcgg aaatgcttgt 1860 gattcaacac agggagagga gggagaggag ccggtctcgg aggaaacagc atctactgcc 1920 tccctgtgtg gatgagccgg agctgctctt ctcagagggg cccagtactt cccgctgggc 1980 cgcagagctc ccgttcccag cagactcctc tgaccctgcc tcccagctca gctactccca 2040 ggaagtggga ggacctttta agacacccat taaggaaacg ctgcccatct cctccacccc 2100 gagcaaatct gtcctcccca gaacccctga atcctggagg ctcacgcccc cagccaaagt 2160 agggggactg gatttcagcc cagtacaaac ctcccagggt gcctctgacc ccttgcctga 2220 ccccctgggg ctgatggatc tcagcaccac tcccttgcaa agtgctcccc cccttgaatc 2280 accgcaaagg ctcctcagtt cagaaccctt agacctcatc tccgtcccct ttggcaactc 2340 ttctccctca gatatagacg tccccaagcc aggctccccg gagccacagg tttctggcct 2400 tgcagccaat cgttctctga cagaaggcct ggtcctggac acaatgaatg acagcctcag 2460 caagatcctg ctggacatca gctttcctgg cctggacgag gacccactgg gccctgacaa 2520 catcaactgg tcccagttta ttcctgagct acagtagagc cctgcccttg cccctgtgct 2580 caagctgtcc accatcccgg gcactccaag gctcagtgca ccccaagcct ctgagtgagg 2640 acagcaggca gggactgttc tgctcctcat agctccctgc tgcctgatta tgcaaaagta 2700 gcagtcacac cctagccact gctgggacct tgtgttcccc aagagtatct gattcctctg 2760 ctgtccctgc caggagctga agggtgggaa caacaaaggc aatggtgaaa agagattagg 2820 aaccccccag cctgtttcca ttctctgccc agcagtctct taccttccct gatctttgca 2880 gggtggtccg tgtaaatagt ataaattctc caaattatcc tctaattata aatgtaagct 2940 tatttcctta gatcattatc cagagactgc cagaaggtgg gtaggatgac ctggggtttc 3000 aattgacttc tgttccttgc ttttagtttt gatagaaggg aagacctgca gtgcacggtt 3060 tcttccaggc tgaggtacct ggatcttggg ttcttcactg cagggaccca gacaagtgga 3120 tctgcttgcc agagtccttt ttgcccctcc ctgccacctc cccgtgtttc caagtcagct 3180 ttcctgcaag aagaaatcct ggttaaaaaa gtcttttgta ttgggtcagg agttgaattt 3240 ggggtgggag gatggatgca actgaagcag agtgtgggtg cccagatgtg cgctattaga 3300 tgtttctctg ataatgtccc caatcatacc agggagactg gcattgacga gaactcaggt 3360 ggaggcttga gaaggccgaa agggcccctg acctgcctgg cttccttagc ttgcccctca 3420 gctttgcaaa gagccaccct aggccccagc tgaccgcatg ggtgtgagcc agcttgagaa 3480 cactaactac tcaataaaag cgaaggtgga caaaaaaaaa aaaaaaa 3527 <210> 7 <211> 2635 <212> DNA <213> Homo sapiens <400> 7 ggccgacgcg agcgccgcgc ttcgcttcag ctgctagctg gcccaaggga ggcgaccgcg 60 gagggtggcg aggggcggcc aggacccgca gccccggggc cgggccggtc cggaccgcca 120 gggagggcag gtcagtgggc agatcgcgtc cgcgggattc aatctctgcc cgctctgata 180 acagtccttt tccctggcgc tcacttcgtg cctggcaccc ggctgggcgc ctcaagaccg 240 ttgtctcttc gatcgcttct ttggacttgg cgaccatttc agagatgtct tccagaagta 300 ccaaagattt aattaaaagt aagtggggat cgaagcctag taactccaaa tccgaaacta 360 cattagaaaa attaaaggga gaaattgcac acttaaagac atcagtggat gaaatcacaa 420 gtgggaaagg aaagctgact gataaagaga gacacagact tttggagaaa attcgagtcc 480 ttgaggctga gaaggagaag aatgcttatc aactcacaga gaaggacaaa gaaatacagc 540 gactgagaga ccaactgaag gccagatata gtactaccgc attgcttgaa cagctggaag 600 agacaacgag agaaggagaa aggagggagc aggtgttgaa agccttatct gaagagaaag 660 acgtattgaa acaacagttg tctgctgcaa cctcacgaat tgctgaactt gaaagcaaaa 720 ccaatacact ccgtttatca cagactgtgg ctccaaactg cttcaactca tcaataaata 780 atattcatga aatggaaata cagctgaaag atgctctgga gaaaaatcag cagtggctcg 840 tgtatgatca gcagcgggaa gtctatgtaa aaggactttt agcaaagatc tttgagttgg 900 aaaagaaaac ggaaacagct gctcattcac tcccacagca gacaaaaaag cctgaatcag 960 aaggttatct tcaagaagag aagcagaaat gttacaacga tctcttggca agtgcaaaaa 1020 aagatcttga ggttgaacga caaaccataa ctcagctgag ttttgaactg agtgaatttc 1080 gaagaaaata tgaagaaacc caaaaagaag ttcacaattt aaatcagctg ttgtattcac 1140 aaagaagggc agatgtgcaa catctggaag atgataggca taaaacagag aagatacaaa 1200 aactcaggga agagaatgat attgctaggg gaaaacttga agaagagaag aagagatccg 1260 aagagctctt atctcaggtc cagtttcttt acacatctct gctaaagcag caagaagaac 1320 aaacaagggt agctctgttg gaacaacaga tgcaggcatg tactttagac tttgaaaatg 1380 aaaaactcga ccgtcaacat gtgcagcatc aattgcttgt aattcttaag gagctccgaa 1440 aagcaagaaa tcaaataaca cagttggaat ccttgaaaca gcttcatgag tttgccatca 1500 cagagccatt agtcactttc caaggagaga ctgaaaacag agaaaaagtt gccgcctcac 1560 caaaaagtcc cactgctgca ctcaatgaaa gcctggtgga atgtcccaag tgcaatatac 1620 agtatccagc cactgagcat cgcgatctgc ttgtccatgt ggaatactgt tcaaagtagc 1680 aaaataagta tttgttttga tattaaaaga ttcaatactg tattttctgt tagcttgtgg 1740 gcattttgaa ttatatattt cacattttgc ataaaactgc ctatctacct ttgacactcc 1800 agcatgctag tgaatcatgt atcttttagg ctgctgtgca tttctcttgg cagtgatacc 1860 tccctgacat ggttcatcat caggctgcaa tgacagaatg tggtgagcag cgtctactga 1920 gactactaac attttgcact gtcaaaatac ttggtgagga aaagatagct caggttattg 1980 ctaatgggtt aatgcaccag caagcaaaat attttatgtt ttgggggttt gaaaaatcaa 2040 agataattaa ccaaggatct taactgtgtt cgcatttttt atccaagcac ttagaaaacc 2100 tacaatccta attttgatgt ccattgttaa gaggtggtga tagatactat tttttttttc 2160 atattgtata gcggttatta gaaaagttgg ggattttctt gatctttatt gctgcttacc 2220 attgaaactt aacccagctg tgttccccaa ctctgttctg cgcacgaaac agtatctgtt 2280 tgaggcataa tcttaagtgg ccacacacaa tgttttctct tatgttatct ggcagtaact 2340 gtaacttgaa ttacattagc acattctgct tagctaaaat tgttaaaata aactttaata 2400 aacccatgta gccctctcat ttgattgaca gtattttagt tatttttggc attcttaaag 2460 ctgggcaatg taatgatcag atctttgttt gtctgaacag gtatttttat acatgctttt 2520 tgtaaaccaa aaacttttaa atttcttcag gttttctaac atgcttacca ctgggctact 2580 gtaaatgaga aaagaataaa attatttaat gttttaaaaa aaaaaaaaaa aaaaa 2635 <210> 8 <211> 1280 <212> DNA <213> Homo sapiens <400> 8 tgccgcagcc cccgcccgcc cgcagagctt ttgaaaggcg gcgggaggcg gcgagcgcca 60 tggccagtcc gggctgcctg ctgtgcgtgc tgggcctgct actctgcggg gcggcgagcc 120 tcgagctgtc tagaccccac ggcgacaccg ccaagaagcc catcatcgga atattaatgc 180 aaaaatgccg taataaagtc atgaaaaact atggaagata ctatattgct gcgtcctatg 240 taaagtactt ggagtctgca ggtgcgagag ttgtaccagt aaggctggat cttacagaga 300 aagactatga aatacttttc aaatctatta atggaatcct tttccctgga ggaagtgttg 360 acctcagacg ctcagattat gctaaagtgg ccaaaatatt ttataacttg tccatacaga 420 gttttgatga tggagactat tttcctgtgt ggggcacatg ccttggattt gaagagcttt 480 cactgctgat tagtggagag tgcttattaa ctgccacaga tactgttgac gtggcaatgc 540 cgctgaactt cactggaggt caattgcaca gcagaatgtt ccagaatttt cctactgagt 600 tgttgctgtc attagcagta gaacctctga ctgccaattt ccataagtgg agcctctccg 660 tgaagaattt tacaatgaat gaaaagttaa agaagttttt caatgtctta actacaaata 720 cagatggcaa gattgagttt atttcaacaa tggaaggata taagtatcca gtatatggtg 780 tccagtggca tccagagaaa gcaccttatg agtggaagaa tttggatggc atttcccatg 840 cacctaatgc tgtgaaaacc gcattttatt tagcagagtt ttttgttaat gaagctcgga 900 aaaacaacca tcattttaaa tctgaatctg aagaggagaa agcattgatt tatcagttca 960 gtccaattta tactggaaat atttcttcat ttcagcaatg ttacatattt gattgaaagt 1020 cttcaatttg ttaacagagc aaatttgaat aattccatga ttaaactgtt agaataactt 1080 gctactcatg gcaagattag gaagtcacag attcttttct ataatgtgcc tggctctgat 1140 tcttcattat gtatgtgact atttatataa cattagataa ttaaatagtg agacataaat 1200 agagtgcttt ttcatggaaa agccttctta tatctgaaga ttgaaaaata aatttactga 1260 aatacaaaaa aaaaaaaaaa 1280 <210> 9 <211> 1449 <212> DNA <213> Homo sapiens <400> 9 gacatgacac cagtggcata tcacggccat ggggtctcag cattccgctg ctgctcgccc 60 ctcctcctgc aggcgaaagc aagaagatga cagggacggt ttgctggctg aacgagagca 120 ggaagaagcc attgctcagt tcccatatgt ggaattcacc gggagagata gcatcacctg 180 tctcacgtgc caggggacag gctacattcc aacagagcaa gtaaatgagt tggtggcttt 240 gatcccacac agtgatcaga gattgcgccc tcagcgaact aagcaatatg tcctcctgtc 300 catcctgctt tgtctcctgg catctggttt ggtggttttc ttcctgtttc cgcattcagt 360 ccttgtggat gatgacggca tcaaagtggt gaaagtcaca tttaataagc aagactccct 420 tgtaattctc accatcatgg ccaccctgaa aatcaggaac tccaacttct acacggtggc 480 agtgaccagc ctgtccagcc agattcagta catgaacaca gtggtcagta catatgtgac 540 tactaacgtc tcccttattc cacctcggag tgagcaactg gtgaatttta ccgggaaggc 600 cgagatggga ggaccgtttt cctatgtgta cttcttctgc acggtacctg agatcctggt 660 gcacaacata gtgatcttca tgcgaacttc agtgaagatt tcatacattg gcctcatgac 720 ccagagctcc ttggagacac atcactatgt ggattgtgga ggaaattcca cagctattta 780 acaactgcta ttggttcttc cacacagcgc ctgtagaaga gagcacagca tatgttccca 840 aggcctgagt tctggaccta cccccacgtg gtgtaagcag aggaggaatt ggttcactta 900 actcccagca aacatcctcc tgccacttag gaggaaacac ctccctatgg taccatttat 960 gtttctcaga accagcagaa tcagtgccta gcctgtgccc agcaaatagt tggcactcaa 1020 taaagatttg cagaatttaa tacagatctt ttcagctgtt cttagggcat tataaatgga 1080 aatcataacg tggttctagg ttatcaaacc atggagtgat gtggagctag gattgtgagt 1140 gacctgcagg ccattatcag tgcctcatct gtgcagaagt ggcagcagag agggaccatc 1200 caaataccta agagaaaaca gacctagtca ggatatgaat ttgtttcagc tgttcccaaa 1260 ggcctgggag ctttttgaaa agaaagaaaa aagtgtgttg gctttttttt ttttttagaa 1320 agttagaatt gtttttacca agagtctatg tggggcttga ttcacccttc atccattggc 1380 tggaacatgg attggggatt tgatagaaaa ataaaccctg cttttgattc aaaaaaaaaa 1440 aaaaaaaaa 1449 <210> 10 <211> 945 <212> DNA <213> Homo sapiens <400> 10 ctgggtgtac agcgtcctcg aaaccacgag caagtgagca gatcctccga ggcaccaggg 60 actccagccc atgccatggc ggattctgag cgcctctcgg ctcctggctg ctgggccgcc 120 tgcaccaact tctcgcgcac tcgaaaggga atcctcctgt ttgctgagat tatattatgc 180 ctggtgatcc tgatctgctt cagtgcctcc acaccaggct actcctccct gtcggtgatt 240 gagatgatcc ttgctgctat tttctttgtt gtctacatgt gtgacctgca caccaagata 300 ccattcatca actggccctg gagtgatttc ttccgaaccc tcatagcggc aatcctctac 360 ctgatcacct ccattgttgt ccttgttgag agaggaaacc actccaaaat cgtcgcaggg 420 gtactgggcc taatcgctac gtgcctcttt ggctatgacg cctatgtcac cttccccgtt 480 cggcagccaa gacatacagc agcccccact gaccccgcag atggcccggt gtaggcgaac 540 ttccctcatt tctctctgca atctgcaaat aactcctcca ttgaaataac tcctccccac 600 cccaacaaca acattcccag cagaccaact cccaccccct ctttgaggta aaagtgcctt 660 tattgggaga cttttgtctt ccagcctgcc aatcaaccct cctgggtgtg gccaccatat 720 gtgtgtgcct aggtcctcct tctgcacgat ccaataggag acaccagttc tgactgaacc 780 atgcccccac ctaagtcaca aaatgaggga agtggggagt tagatttcag agtccaggcc 840 ctaggttggg acccactcca aataatctcc tcggtgtggg tggtggttct atagagggat 900 aaatgaataa taaacattgt taaaatataa aaaaaaaaaa aaaaa 945 <210> 11 <211> 4574 <212> DNA <213> Homo sapiens <400> 11 ggcggctgct cccattgagc tgtctgctcg ctgtgcccgc tgtgcctgct gtgcccgcgc 60 tgtcgccgct gctaccgcgt ctgctggacg cgggagacgc cagcgagctg gtgattggag 120 ccctgcggag agctcaagcg cccagctctg cccgaggagc ccaggctgcc ccgtgagtcc 180 catagttgct gcaggagtgg agccatgagc tgcgtcctgg gtggtgtcat ccccttgggg 240 ctgctgttcc tggtctgcgg atcccaaggc tacctcctgc ccaacgtcac tctcttagag 300 gagctgctca gcaaatacca gcacaacgag tctcactccc gggtccgcag agccatcccc 360 agggaggaca aggaggagat cctcatgctg cacaacaagc ttcggggcca ggtgcagcct 420 caggcctcca acatggagta catgacctgg gatgacgaac tggagaagtc tgctgcagcg 480 tgggccagtc agtgcatctg ggagcacggg cccaccagtc tgctggtgtc catcgggcag 540 aacctgggcg ctcactgggg caggtatcgc tctccggggt tccatgtgca gtcctggtat 600 gacgaggtga aggactacac ctacccctac ccgagcgagt gcaacccctg gtgtccagag 660 aggtgctcgg ggcctatgtg cacgcactac acacagatag tttgggccac caccaacaag 720 atcggttgtg ctgtgaacac ctgccggaag atgactgtct ggggagaagt ttgggagaac 780 gcggtctact ttgtctgcaa ttattctcca aaggggaact ggattggaga agccccctac 840 aagaatggcc ggccctgctc tgagtgccca cccagctatg gaggcagctg caggaacaac 900 ttgtgttacc gagaagaaac ctacactcca aaacctgaaa cggacgagat gaatgaggtg 960 gaaacggctc ccattcctga agaaaaccat gtttggctcc aaccgagggt gatgagaccc 1020 accaagccca agaaaacctc tgcggtcaac tacatgaccc aagtcgtcag atgtgacacc 1080 aagatgaagg acaggtgcaa agggtccacg tgtaacaggt accagtgccc agcaggctgc 1140 ctgaaccaca aggcgaagat ctttggaact ctgttctatg aaagctcgtc tagcatatgc 1200 cgcgccgcca tccactacgg gatcctggat gacaagggag gcctggtgga tatcaccagg 1260 aacgggaagg tccccttctt cgtgaagtct gagagacacg gcgtgcagtc cctcagcaaa 1320 tacaaacctt ccagctcatt catggtgtca aaagtgaaag tgcaggattt ggactgctac 1380 acgaccgttg ctcagctgtg cccgtttgaa aagccagcaa ctcactgccc aagaatccat 1440 tgtccggcac actgcaaaga cgaaccttcc tactgggctc cggtgtttgg aaccaacatc 1500 tatgcagata cctcaagcat ctgcaagaca gccgtgcacg cgggagtcat cagcaacgag 1560 agtgggggtg acgtggacgt gatgcccgtg gataaaaaga agacctacgt gggctcgctc 1620 aggaatggag ttcagtctga aagcctgggg actcctcggg atggaaaggc cttccggatc 1680 tttgctgtca ggcagtgaat ttccagcacc aggggagaag gggcgtcttc aggagggctt 1740 cggggttttg cttttatttt tattttgtca ttgcggggta tatggagagt caggaaactt 1800 cctttgactg atgttcagtg tccatcactt tgtggcctgt gggtgaggtg acatctcatc 1860 ccctcactga agcaacagca tcccaaggtg ctcagccgga ctccctggtg cctgatcctg 1920 ctggggcccg ggggtctcca tctggacgtc ctctctcctt tagagatctg agctgtctct 1980 taaaggggac agttgcccaa aatgttcctt gctatgtgtt cttctgttgg tggaggaagt 2040 tgatttcaac ctccctgcca aaagaacaaa ccatttgaag ctcacaattg tgaagcattc 2100 acggcgtcgg aagaggcctt ttgagcaagc gccaatgagt ttcaggaatg aagtagaagg 2160 tagttattta aaaataaaaa acacagtccg tccctaccaa tagaggaaaa tggttttaat 2220 gtttgctggt cagacagaca aatgggctag agtaagaggg ctgcgggtat gagagacccc 2280 ggctccgccc tggcacgtgt ccttgctggc ggcccgccac aggccccctt caatggccgc 2340 attcaggatg gctctataca cagcagtgct ggtttatgta gagttcagca gtcacttcag 2400 agatgtatct tgtctttgtc aggcccttca tcttcatggc ccacctgttt tctgccgtga 2460 cctttggtcc cattgaggac taaggatcgg gaccctttct ttacccccta cccattgtgg 2520 ctcccaccct gcctcggact ggtttacgtg tcctggttca cacccaggac ttttctttgc 2580 aagcgaacct gtttgaagcc caagtcttaa ctcctggtct cgtaaggttc cactgagacg 2640 agatgtctga gaacaaccaa agaaggcctg ctctttgctg cttttaaaaa atgacaatta 2700 aatgtgcaga ttccccacgc acccgatgac ctattttttc agccgtggga ggaatggagt 2760 ctttggtaca ttcctcaccg aggttagcag ctcagtttgt ggttatgaaa ccgtctgtgg 2820 cctcatgaca gcgagagatg ggaatacact agaaggatct cttttcctgt tttcgtgaaa 2880 cgactcttgc caaacgttcc cgaggcgcca aggagtgtag tacaccctgg ctgccatcac 2940 tctataaaag tgcttcatga gcccagacca aaagcccaca gtgaaatgaa gtaccctttt 3000 gtaaatagca tttttttgca gaaggtgaaa attccactct ctaccaccgg gccagccaat 3060 agatcacttt ggtgaatgct agtttcaaat ttgattcaaa atatttctta ggtgaaagaa 3120 ctagcagaaa gtcaaaaact aagatactgt agactggaca agaaattcta cctgggcacc 3180 taggtgatgc cttctttctt tgattgcctt tctaataaat gcagaatctg aaggtaaata 3240 ggtttaaaac aaaacaaaaa cccacccctt taaggagttg gtaaaaagca gttcaactct 3300 tagcttgact gagctaaaat tcacaggact acgtgctttg tgcattgtag tctagtcgta 3360 attcataggt actgactcct cagccccaaa tgtcggagag gaagaattcg gtcagcctgt 3420 caggtcgtga gtccagttac caccaaacat ctgggaaact tctgggtgct gggtgctctg 3480 ctgctggact tttgtggctg tgtctgtgtc tgcaagataa attagatcgc cctgtggggt 3540 ttgcagaatt agtgaagggt ccaggacgat cccagtgggc tcgcttccaa agcatcccac 3600 tcaagggaga cttgaaactt ccagtgtgag ttgaccccat catttaaaaa taaagtcccc 3660 gggttcctta atgcctcctt cactgggcct tcctagcagg atagaaagtc cttgcccaga 3720 gcaggacctg gctgtctttt tttttttttt tttcccgaga ccaagtttca ctctgttgcc 3780 caaggtagag tgcagtggcg tgatctctgc tcattgcaac tgccgcctcc cgggttcaag 3840 caattctcat gcatcagcct cccaagtacc tgggactaca ggcgtgagct accatgcccg 3900 gctaattttt gtatttttag tagagatggg gtttcattat gttggccagg ctggtctcga 3960 actccttacc tcaggtgatc cacccacctt ggcctcccga agtgctggga ttacaggcat 4020 gagccactgc gcccggccat ggacctggct gtctttatca tccccacaaa cattttgaaa 4080 ctggaatatt tgtcttcaga aaatggaaac aagactataa atgataagcc ctgtccctag 4140 caccacctct cctgtgtgtg gaatagaggc ccctcgtgct accaacactt accctgtgtt 4200 taaaaagatc ttgtaccaag ccaacggcgt tcctggctct cctgcccaca ggatgaacat 4260 tttcggcttc cttaggagtt ttgccctacc gtattccaaa gcgtgtgctg gtttctcata 4320 ttgtctgtag gctcactcag cccgcagttt atgtgtgtgc ttttttctat gaaaaatgat 4380 gtattttgct acttcctgtg tacaaagttt tattgtaaat gttttttgtg ctttgcatga 4440 acaggggcca cgttgttgca attgtttcag tagaactggt ttgatttcta aaatgttcct 4500 gtaacatatc ttttatgaac aaatctgaac aatttgtgaa ataaaacatt gaaaaccaaa 4560 aaaaaaaaaa aaaa 4574 <210> 12 <211> 3414 <212> DNA <213> Homo sapiens <400> 12 gcttacacag tatggccggc gacattagct agcgctcgct ctactctctc taacgggaaa 60 gcagcggaat acaagagact gaactgtatc tgcctctatt tccaaaagac tcacgttcaa 120 ctttcgctca cacaaagccg ggaaaatttt attagtcctt tttttaaaaa aagttaatat 180 aaaattatag caaaaaaaaa aaggaacctg aactttagta acacagctgg aacaatcgca 240 gcggcggcgg cagcggcggg agaagaggtt taatttagtt gattttctgt ggttgttggt 300 tgttcgctag tctcacggtg atggaagctg cacatttttt cgaagggacc gagaagctgc 360 tggaggtttg gttctcccgg cagcagcccg acgcaaacca aggatctggg gatcttcgca 420 ctatcccaag atctgagtgg gacatacttt tgaaggatgt gcaatgttca atcataagtg 480 tgacaaaaac tgacaagcag gaagcttatg tactcagtga gagtagcatg tttgtctcca 540 agagacgttt cattttgaag acatgtggta ccaccctctt gctgaaagca ctggttcccc 600 tgttgaagct tgctagggat tacagtgggt ttgactcaat tcaaagcttc ttttattctc 660 gtaagaattt catgaagcct tctcaccaag ggtacccaca ccggaatttc caggaagaaa 720 tagagtttct taatgcaatt ttcccaaatg gagcaggata ttgtatggga cgtatgaatt 780 ctgactgttg gtacttatat actctggatt tcccagagag tcgggtaatc agtcagccag 840 atcaaacctt ggaaattctg atgagtgagc ttgacccagc agttatggac cagttctaca 900 tgaaagatgg tgttactgca aaggatgtca ctcgtgagag tggaattcgt gacctgatac 960 caggttctgt cattgatgcc acaatgttca atccttgtgg gtattcgatg aatggaatga 1020 aatcggatgg aacttattgg actattcaca tcactccaga accagaattt tcttatgtta 1080 gctttgaaac aaacttaagt cagacctcct atgatgacct gatcaggaaa gttgtagaag 1140 tcttcaagcc aggaaaattt gtgaccacct tgtttgttaa tcagagttct aaatgtcgca 1200 cagtgcttgc ttcgccccag aagattgaag gttttaagcg tcttgattgc cagagtgcta 1260 tgttcaatga ttacaatttt gtttttacca gttttgctaa gaagcagcaa caacagcaga 1320 gttgattaag aaaaatgaag aaaaaacgca aaaagagaac acatgtagaa ggtggtggat 1380 gctttctaga tgtcgatgct gggggcagtg ctttccataa ccaccactgt gtagttgcag 1440 aaagccctag atgtaatgat agtgtaatca ttttgaattg tatgcattat tatatcaagg 1500 agttagatat cttgcatgaa tgctctcttc tgtgtttagg tattctctgc cactcttgct 1560 gtgaaattga agtggatgta gaaaaaacct tttactatat gaaactttac aacacttgtg 1620 aaagcaactc aatttggttt atgcacagtg taatatttct ccaagtatca tccaaaattc 1680 cccacagaca aggctttcgt cctcattagg tgttggcctc agcctaaccc tctaggactg 1740 ttctattaaa ttgctgccag aattttacat ccagttacct ccactttcta gaacatattc 1800 tttactaatg ttattgaaac caatttctac ttcatactga tgtttttgga aacagcaatt 1860 aaagtttttc ttccatagtt gagtccttag aaaatgattc cagttactca ttttgcatat 1920 tgctatttaa cattattgga ccctgcattt atagtccttt gatttcttcc ctctccctgg 1980 tgtctccccc aagaccccaa ataaagcaat accctgttaa cactgtgggt ttatatacta 2040 attctatacc ccagatgggg aattaggggg gagatggtcc ctgggcttaa tattctttaa 2100 agggcatggg aatttagcct ctcttttatt gtaatgtgct cttttggaaa atagttggtt 2160 agcagggaga ccagagttgt agattgagat tgggtgtact ggctgttctg tggaaaacat 2220 acattctgtg ttcctcgaat aagtgaaatt gagcttctaa tgagatgcac ccctttacta 2280 acttgatgat gatataaaat tcatttttat ttagttaatt accagagaga tttagcataa 2340 ttttgcttct ggattcagta aatcaagtca gcttggatca ttcaccttaa cttttccttt 2400 agcagccctt tccactagtt tcccattaag tagtgttcta taaactttga tccaaagcag 2460 aatcaatgtc ttttccatct cgtgacttaa agttctgtga ctgtgatgca tgtgagtgtt 2520 ccgacttcat ctgttcctct taactacggt gtttccctta ccgatcggca ttcataggat 2580 gaaatgaatg actgtcccag aatgagaatt tgtccagatt attcagataa acatcataaa 2640 gagaataaca ttataaataa gtagaatatg aataaataga ataataaaat tccaaaatac 2700 tcaatgggaa atgactagta atataggctt tcaagagttg gtacctttac gtatatttgc 2760 agattctctg ggattttaag gaactgagaa aacagaaaag ttgactaaat tttatatttc 2820 ttgtcctcta aatattttga taatttctgg attgatgcag tgatgttttt cgttccttgt 2880 atttataaat gaaaaccttt ttttggtgtt tctaaaccta aaatctactt ggtttgaaat 2940 caagtggttg gaacactgtt tgacttttat ttgaagcatg ttgttgattg aaaatttcat 3000 tgaggaagtt ttcaatcagt gtgatcagtt tgattctgta atgagcacag cacctaatat 3060 tttgaggagc tctgttttga ggaccaatgc ttaaggtgga ccttgttgct aaacaatatc 3120 ccaatagatt tgttgacttg aggtctggtt tggttttgtt tttgttttgt tttggttttg 3180 ttttgtttcc caatagaatt aagaattcta atgttgaaaa actgtataaa tttttatggg 3240 acaaagccta gaaaagagaa atgtagtttg aatcataatc taaatcatcg tatgatagga 3300 aggaaaagtt ttggtgccat aatttctcct ttcactggtg ttggacttaa atcagttgaa 3360 atgtatttct gtaccacaat ttacgcttca ataaaagttt aattgtctag tgag 3414 <210> 13 <211> 1558 <212> DNA <213> Homo sapiens <400> 13 gagtgcaaag cgctctccct ccctcgccca gccttcgtcc tcctggcccg ctcctctcat 60 ccctcccatt ctccatttcc cttccgttcc ctccctgtca gggcgtaatt gagtcaaagg 120 caggatcagg ttccccgcct tccagtccaa aaatcccgcc aagagagccc cagagcagag 180 gaaaatccaa agtggagaga ggggaagaaa gagaccagtg agtcatccgt ccagaaggcg 240 gggagagcag cagcggccca agcaggagct gcagcgagcc gggtacctgg actcagcggt 300 agcaacctcg ccccttgcaa caaaggcaga ctgagcgcca gagaggacgt ttccaactca 360 aaaatgcagg ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca 420 ttcattttca tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa 480 aaaaaagtga agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt 540 ggagactgtg ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc 600 atgaagaccc agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc 660 aaataccagt tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact 720 ggaagtctga agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag 780 ccctgtggca aactgaccaa gcccaaacct caagcagaat ctaagaagaa gaaaaaggaa 840 ggcaagaaac aggagaagat gctggattaa aagatgtcac ctgtggaaca taaaaaggac 900 atcagcaaac aggatcagtt aactattgca tttatatgta ccgtaggctt tgtattcaaa 960 aattatctat agctaagtac acaataagca aaaacaaaaa gaaaagaaaa tttttgtagt 1020 agcgtttttt aaatgtatac tatagtacca gtaggggctt ataataaagg actgtaatct 1080 tatttaggaa gttgacttat agtacatgat aaatgataga caattgaggt aagttttttg 1140 aaattatgtg acattttaca ttaaattttt tttacatttt ttgggcagca atttaaatgt 1200 tatgactatg taaactactt ctcttgttag gtaatttttt tcacctagat ttttttccca 1260 attgagaaaa atatatacta aacaaaatag caataaaaca taatcactct atttgaagaa 1320 aatatcttgt tttctgccaa tagatttttt aaaatgtagt cagcaaaatg ggggtgggga 1380 agcagagcat gtcctagttc aatgttgact tttttttttt ttaaagaaaa gcattaagac 1440 ataaaattct ttcactttgg cagaagcatt tgttttcttg atgaaattat ttttccatct 1500 gaggaaaaaa atactaggaa aataaatcaa ggtgatgctg aaaaaaaaaa aaaaaaaa 1558 <210> 14 <211> 1416 <212> DNA <213> Homo sapiens <400> 14 acgggctatt taaaggtacg cgccgcggcc aaggccgcac cgtactgggc gggggtctgg 60 ggagcgcagc agccatggca agccgtctcc tgctcaacaa cggcgccaag atgcccatcc 120 tggggttggg tacctggaag tcccctccag ggcaggtgac tgaggccgtg aaggtggcca 180 ttgacgtcgg gtaccgccac atcgactgtg cccatgtgta ccagaatgag aatgaggtgg 240 gggtggccat tcaggagaag ctcagggagc aggtggtgaa gcgtgaggag ctcttcatcg 300 tcagcaagct gtggtgcacg taccatgaga agggcctggt gaaaggagcc tgccagaaga 360 cactcagcga cctgaagctg gactacctgg acctctacct tattcactgg ccgactggct 420 ttaagcctgg gaaggaattt ttcccattgg atgagtcggg caatgtggtt cccagtgaca 480 ccaacattct ggacacgtgg gcggccatgg aagagctggt ggatgaaggg ctggtgaaag 540 ctattggcat ctccaacttc aaccatctcc aggtggagat gatcttaaac aaacctggct 600 tgaagtataa gcctgcagtt aaccagattg agtgccaccc atatctcact caggagaagt 660 taatccagta ctgccagtcc aaaggcatcg tggtgaccgc ctacagcccc ctcggctctc 720 ctgacaggcc ctgggccaag cccgaggacc cttctctcct ggaggatccc aggatcaagg 780 cgatcgcagc caagcacaat aaaactacag cccaggtcct gatccggttc cccatgcaga 840 ggaacttggt ggtgatcccc aagtctgtga caccagaacg cattgctgag aactttaagg 900 tctttgactt tgaactgagc agccaggata tgaccacctt actcagctac aacaggaact 960 ggagggtctg tgccttgttg agctgtacct cccacaagga ttaccccttc catgaagagt 1020 tttgaagctg tggttgcctg ctcgtcccca agtgacctat acctgtgttt cttgcctcat 1080 ttttttcctt gcaaatgtag tatggcctgt gtcactcagc agtgggacag caacctgtag 1140 agtggccagc gagggcgtgt ctagcttgat gttggatctc aagagccctg tcagtagagt 1200 agaagtctct tccagtttgc tttgcccttc tttctaccct gctggggaaa gtacaacctg 1260 aatacccttt tctgaccaaa gagaagcaaa atctaccagg tcaaaatagt gccactaacg 1320 gttgagtttt gactgcttgg aactggaatc ctttcagcaa gacttctctt tgcctcaaat 1380 aaaaagtgct tttgtgagaa aaaaaaaaaa aaaaaa 1416 <210> 15 <211> 6400 <212> DNA <213> Homo sapiens <400> 15 ctgagatgca ggcccagcgc tggcgcagtg agaacttcga gagacccgtg gacctggagg 60 gctctgggga tgatgactcc tttcccgatg atgaactgga tgacctctac tcggggtcgg 120 gctcgggctg taagtacccc cctccctacc tctgcctggg ggcagtgacc agtctgtatc 180 cagcctcaac tctgagaagc ccacgggggg cttgcttcag tgaggcaggg ggcattcact 240 gcctgggtca ggcaagttct tcttgctctg gatccccaga acaagaaggg cagaacatcc 300 ttctggggat agaacaagac ctgggaggac ctcagggccc agaatgtcca ggtctccagg 360 gtcccacgtc tgcatctttg tgtgtgctat gtggctttct ctgcagacct tgcttggttc 420 cggtggtccc gtcaggtgca ataagctgtg gccaatggtg gggttagggc agtgatgaca 480 cagggcaggt gcttcaagtg gtgcctggga tggccccgcc ctggggaagg ggagccaggt 540 cagctgggtc tagcagaatc tcgggagaga agggcaccgc gaaccccact ctgccatgta 600 gcaactgtgt gcccctcggt gctccccctc cctgaatccc tgtattttca cctgtggatg 660 gtgagaaata cgacttcttc tcagtgcctc taggagggtt tgggatagga agctggggtc 720 tggcacagag gaggagctct caaaatggta gcaaaaagaa ggcagctgag actgggccca 780 gtgagggcac gggctggcat ctgaggagat ggtacggggt ctgcacgcca cagagctggc 840 tccccacagc cctcgcctct ggtctcccct ccttagccaa gtcctttgag cctctttcaa 900 attaatcttt gtaaaacccg tttatattgg gtcacatctc tattcgcaaa gttccctggc 960 tcccctccct cctgcctggt tccgagccca ggagctggct gtggcttctc cctcccccat 1020 cccctactcc ccgtctcatt tcctcccaag ttccttcact gtcccggctt tgcgtcagcc 1080 agattgctca agcagttccc ctgcctcaag ggcttctttt cccttttacc ctccgcctct 1140 gcctctgggg gaagccctta gtgtaccacc cctgccttga gcttgtggta ggggtgcctt 1200 tggggtctga ctcttcccag aatgccactc ctgtgttccc ctgcaagccc cagcaagttt 1260 tgcagccagt agcgcctcag ttgctgctgc ctggattcaa cctcatagaa actgtaggct 1320 gggtgggcag gaatagtcaa ggaaggcttc ccgggagagg cggcccccag aatttttgac 1380 ttggcagaga gaagttgggg aacatcagca actgaccacc tttagctggc tgtgccttcc 1440 tcctttctct catcttttct gggaaaattg ggtaaagaga gggggttggg agacctaatc 1500 ttgatggcca ttgcttacct gggatcctca tgcccctcac aaccacccag ctccctagct 1560 ctctccctct cccccacccc ctcagacttc gagcaggagt cgggcattga gacagccatg 1620 cgcttcagcc cagatgtagc cctggcggtg tccaccacac ctgcggtgct gcccaccacg 1680 aacatccagc ctgtgggcac accatttgaa gagctcccct ctgagcgccc caccctggag 1740 ccagccacca gccccctggt ggtgacagaa gtcccggaag agcccagcca gagagccacc 1800 accgtctcca ctaccatggc taccactgct gccacaagca caggggaccc gactgtggcc 1860 acagtgcctg ccacagtggc caccgccacc cccagcaccc ctgcagcacc cccttttacg 1920 gccaccactg ctgttataag gaccactggc gtacggaggc ttctgcctct cccactgacc 1980 acagtggcta cggcacgggc cactaccccc gaggcgccct ccccgcccac cacggcggct 2040 gtcttggaca ccgaggcccc aacacccagg ctggtcagca cagctacctc ccggccaaga 2100 gcccttccca ggccggccac cacccaggag cctgacatcc ctgagaggag caccctgccc 2160 ctggggacca ctgcccctgg acccacagag gtggctcaga ccccaactcc agagaccttc 2220 ctgaccacaa tccgggatga gccagaggtt ccggtgagtg gggggcccag tggagacttc 2280 gagctgccag aagaagagac cacacaacca gacacagcca atgaggtggt agctgtggga 2340 ggggctgcgg ccaaggcatc atctccacct gggacactgc ccaagggtgc ccgcccgggc 2400 cctggcctcc tggacaatgc catcgactcg ggcagctcag ctgctcagct gcctcagaag 2460 agtatcctgg agcggaagga ggtgctcgta gctgtgattg tgggcggggt ggtgggcgcc 2520 ctctttgctg ccttcttggt cacactgctc atctatcgta tgaagaaaaa ggatgagggc 2580 agctacacgc tggaggaacc caagcaggcg agcgtcacat accagaagcc tgacaagcag 2640 gaggagttct atgcctagtg gagccacagt gcctccctgc agcctcaaca ccaccctgct 2700 gtccagtccc cagcctggcc ccaccagccc aagcctggga ctgggcctgg aacctggccc 2760 cagttcttct ctgccctctc tcccaaggtc tgcccaggct gccagcctca cacagatctt 2820 ccccgaggaa gaggggctgc tgccatctgc cccagactgt gcccttacga gctcatctct 2880 tgttcccctc atccctgcca ccagtctggg gcttcaggac ctcatgtcag atggatggga 2940 ggaagaaagc tcctgattgg ctggtggtgg aagaaagggt ggggcttgag atgagcctga 3000 gccctgactt ggcacccaca gtgctcactg agatctcctt tttggggcag agaggcactc 3060 aggctggttt ccaggacaaa catttggtaa acacagccct tgaaatcatc tagacactgc 3120 aacctcttgc tcgtatccca gggcctctct ctagctgggt gagagggtgt cccttgtcac 3180 cagcctgttt tgtcctggtc tctctggggt tgttgaatct ctcctcttgc ctgccaagta 3240 cacatgtacc cagacttcat ttctttctgc atcttccccc aagaaacagc ttcctgaggg 3300 tgctggggca gccactggtg aggaggggct gctctgatgt ccctcctatg aggggactct 3360 gcacagacac cattgcccac actatcacca tattttcact cagtcacaca caagacaaaa 3420 gcatgcaatg acaaaaccat acgcaatcct gaccgcccag ccaatcaaga catatcacag 3480 aacacacgcg tccttccaag aatgtttatc ctcatgcatc acttacacac ccccagacac 3540 gtactgcaat gcaagtcact agtcatggtc acatgacagt gacagtgtgg cctcctccta 3600 ccccaaatac acccacactc tggcaccaca cacattgtct ccagctttca ggcttactgg 3660 ggagggtgga atcgagccag aacaatcagc ccatattggg tccccctaag ttgccccgtc 3720 atactcagtc ccatgccatg gtgcccacac caaccatgca gccaccaacc ccagccagtg 3780 tcagacacaa tcccatgtgg atgcacagtc tcactccaca tgacctgctc tcaatgctgg 3840 agggaaacag gcaggccctt gcctttctcg gaaaaagtgt ggggccacag cccttttagg 3900 gcattgcatg caggtgggcc tggcttcacc cctacctgct tcctccccac cgcagctggc 3960 agagggggag gtttggggcc agacccccac tagctgggag cctgggggct cctctaaggc 4020 tgaggaagga aatttggccc caggttgttg gggggtcttg ggtctcccag gacggaaggc 4080 ccagggcagg gagggggcat gtggttgggc tcctttatct ccctgtgtcc ccttcctgct 4140 ttgagctagg gggctgactc tgcctcccag gacacaagtc tccaaagtgc ctgtgagggc 4200 gggccctccg caccctctgc cctctgcctg gcaggccaac ctcagcccac ctgcccagag 4260 gccctccctg tggacacccc ctcacctatt tggccaaaca attctggctg cagcttcagg 4320 ggccatggct ggaagcagcc cctgcagatc cctcaggccc cgaggtcagg gtttgaggga 4380 tgagaccagg tgatagtggg ggaggggtta cttcctttgt tacctagcaa gtagggctat 4440 ttccatcggt attttaaatg tggggtcaca gatcttttgg ggagggtgtg cttggcaggg 4500 ggcctcttgg agccaaaggg atgtggtgtg agttgcgatt ggctggcact cacaccccca 4560 cccctcaccc acatcccaga ttcaagtcag gaaggcaggt tttatttcag ggcccttttc 4620 aagatgccct ggcagcagat ttctgcagga tgaggggtag cggtgtgtag gcagtgaggg 4680 ggaggttcca ggggctgtcc cacagcctgt cttttccagg ctgggctcca tcttccagtc 4740 ccaaaaccct ccttcacagg gcccagaggc ttgtgaggaa gccaggtgga cccagccttg 4800 gaagagtggg catggggggc ccctgatatc tggagggggc gggttggcct cagtcatctt 4860 tggagcagaa gggctgggtc ctggggccac agaccacaag gctcagcctc cctaccctgc 4920 tccctggggt gctgctgtct tggagagcac agctctggtg agacggcctg ggcaggccga 4980 ggctgagaaa ccagggagga tagaggagaa aagggcttgg gcccccagcc ccagaagatg 5040 ctgggcccca ggtgggagac ccaacagtgg gtgcagtttc tcagtggggc tggagccaat 5100 ggtgggggtg gccccggcag gcctggctcc tcacatccca ggggttggct tctgatttgg 5160 ggcttgggct ccaggcactg gcttctcttc tctgtgtcct tagcatttga gagaagaggc 5220 caggggcctt gttcatggat ccctggaccc aaggcagatg tccaggcttt atcctcctga 5280 ggatgaggag tctgaccagc ccaaatctgc cctggccggc ctgaccgggg caaggcagtc 5340 caagagagtt cagtgaggac cagctaggct ctcccaggtg caatgtgggt gcagggccct 5400 catgtccccc tacccctgcc tgtgatggag tgttctgagg ggctttggca tttgctggaa 5460 gcacagggag ttccaaatga gagggagctt ctgtggcttg agagcctctg gggccttggc 5520 tgccagagca cgaggcaggc caggacctgg agagcccaga ccctgtctcc aggaggccag 5580 gaggccagat gggggccttg cctgaaagac tggtcccctt gatcgctgga ggcatgtggg 5640 tggcaaccag ggctgggcag ggcttagggt gtgtgggcca aacccccctg gggttggcaa 5700 agccgcctgt caggcctcct ggtgggggcc cctggacaca gggagcagac cctctgcctc 5760 atggggtagg agtggctgcc tcctgtgttc tctggatttc ttctcccaac aactacaacc 5820 ctggacttgc ctccccaggc ctcttgcctg taaatagaag cccgcaaact gtacagattt 5880 acagaggcat cgagactggg ccctgggagt tgccatctga gagccgatgg ccccagcatc 5940 ccccaggtgc ctgcctggca ccacagtgac cctggcctca gcgtggcaaa tgcatgtaaa 6000 tatttttcgt aggcagcgtg gctccagaga gccccctgaa gacagtgtcc ctccctcctg 6060 tgagtccttt ctcctgtaca gaacctgcct ggggtgggtg ggggtctgcc attccctccc 6120 ccaggccttc cctgcccctt ctctcccctg taacctgttt attaaccata cctgtcctga 6180 gttcatggcc aaaaccttaa ataagaaaaa caaaagaaaa agacagtgga aaaaagagac 6240 caaggcgcct gccccactgc gggtactctc ctgttccagc cttgtgaagg aactggtttt 6300 gtttttgttt ttgttttttt tttttttgtt tgtttgtttg ttttttaaca cttcctgtgc 6360 tgtgcccatt tataagagga aataaaatta agctgaaatg 6400 <210> 16 <211> 5487 <212> DNA <213> Homo sapiens <400> 16 tctgtcgact tgccccagag ctgatccttg tctttgtcca cttctcagcg aggatggcac 60 ttcagggagc ccttccctta ctatcgcaga gagagcaggc cctccccagt catgtccaac 120 ccagaactct gttttgtttt cttcatagcc ctagcatcac agaaaatcac cctgtgcatt 180 catggatgtc cacgggggca agggctttgt gttgcttaac ccagcatcct gaaccgtgtt 240 tgttgaatga atacagaacc ccgtttgctc tgggagagca cagaaaacag tcttctatca 300 tatatcatag ccagctgcaa acagcagatg gcttcccata tcccagagag taagaaccag 360 agagagagag aaagagagag agtttgggtc tttctcctct gtgcctgctc tctccagaga 420 aactggaggg gtagcagtta gcattccccc gctggttcca ccaagcacag tcaaggtctc 480 taggacatgg ccacccctca cctgtggaag cggtcctgct ggggtgggtg ggtgttagtt 540 ggttctggtt tgggtcagag acacccagtg gcccaggtgg gcgtggggcc agggcgcaga 600 cgagaagggg cacgagggct ccgctccgag gacccagcgg caagcaccgg tcccgggcgc 660 gccccagccc acccactcgc gtgcccacgg cggcattatt ccctataagg atctgaacga 720 tccgggggcg gccccgcccc gttacccctt gcccccggcc ccgccccctt tttggagggc 780 cgatgaggta atgcggctct gccattggtc tgagggggcg ggccccaaca gcccgaggcg 840 gggtccccgg gggcccagcg ctatatcact cggccgccca ggcagcggcg cagagcgggc 900 agcaggcagg cggcgggcgc tcagacggct tctcctcctc ctcttgctcc tccagctcct 960 gctccttcgc cgggaggccg cccgccgagt cctgcgccag cgccgaggca gcctcgctgc 1020 gccccatccc gtcccgccgg gcactcggag ggcagcgcgc cggaggccaa ggttgccccg 1080 cacggcccgg cgggcgagcg agctcgggct gcagcagccc cgccggcggc gcgcacggca 1140 actttggaga ggcgagcagc agccccggca gcggcggcag cagcggcaat gaccccttgg 1200 ctcgggctca tcgtgctcct gggcagctgg agcctggggg actggggcgc cgaggcgtgc 1260 acatgctcgc ccagccaccc ccaggacgcc ttctgcaact ccgacatcgt gatccgggcc 1320 aaggtggtgg ggaagaagct ggtaaaggag gggcccttcg gcacgctggt ctacaccatc 1380 aagcagatga agatgtaccg aggcttcacc aagatgcccc atgtgcagta catccacacg 1440 gaagcttccg agagtctctg tggccttaag ctggaggtca acaagtacca gtacctgctg 1500 acaggtcgcg tctatgatgg caagatgtac acggggctgt gcaacttcgt ggagaggtgg 1560 gaccagctca ccctctccca gcgcaagggg ctgaactatc ggtatcacct gggttgtaac 1620 tgcaagatca agtcctgcta ctacctgcct tgctttgtga cttccaagaa cgagtgtctc 1680 tggaccgaca tgctctccaa tttcggttac cctggctacc agtccaaaca ctacgcctgc 1740 atccggcaga agggcggcta ctgcagctgg taccgaggat gggccccccc ggataaaagc 1800 atcatcaatg ccacagaccc ctgagcgcca gaccctgccc cacctcactt ccctcccttc 1860 ccgctgagct tcccttggac actaactctt cccagatgat gacaatgaaa ttagtgcctg 1920 ttttcttgca aatttagcac ttggaacatt taaagaaagg tctatgctgt catatggggt 1980 ttattgggaa ctatcctcct ggccccaccc tgccccttct ttttggtttt gacatcattc 2040 atttccacct gggaatttct ggtgccatgc cagaaagaat gaggaacctg tattcctctt 2100 cttcgtgata atataatctc tattttttta ggaaaacaaa aatgaaaaac tactccattt 2160 gaggattgta attcccaccc ctcttgcttc ttccccacct caccatctcc cagaccctct 2220 tccctttgcc cttctcctcc aatacataaa ggacacagac aaggaacttg ctgaaaggcc 2280 aaccatttca ggatcagtca aaggcagcaa gcagatagac tcaaggtgtg tgaaagatgt 2340 tatacaccag gagctgccac tgcatgtccc aaccagactg tgtctgtctg tgtctgcatg 2400 taagagtgag ggagggaagg aaggaactac aagagagtcg gagatgatgc agcacacaca 2460 caattcccca gcccagtgat gcttgtgttg accagatgtt cctgagtctg gagcaagcac 2520 ccaggccaga ataacagagc tttcttagtt ggtgaagact taaacatctg cctgaggtca 2580 ggaggcaatt tgcctgcctt gtacaaaagc tcaggtgaaa gactgagatg aatgtctttc 2640 ctctccctgc ctcccaccag acttcctcct ggaaaacgct ttggtagatt tggccaggag 2700 ctttctttta tgtaaattgg ataaatacac acaccataca ctatccacag atatagccaa 2760 gtagatttgg gtagaggata ctatttccag aatagtgttt agctcaccta gggggatatg 2820 tttgtataca catttgcata tacccacatg gggacataag ctaatttttt tacaggacac 2880 agaattctgt tcaatgctgt taaatatgcc aatagtttaa tctcttctat tttgttgtcg 2940 ttgcttgttt gaagaaaatc atgacattcc aagttgacat ttttttttca ttttaattaa 3000 aatttgaaat tctgaacacc gtcagcaccc tctcttccct atcatgggtc atctgacccc 3060 tgtccgtctc cttgtccctg cttcatgttt gggggccttt ctttaactgc cttcctggct 3120 tagctcagat ggcagatgag agtgtagtca agggcctggg cacaggaggg agagctgcag 3180 agtgtcctgc ctgccttggc tggagggaca cctctcctgg gtgtggagac agcttggttc 3240 cctttcccta gctccctggt gggtgaatgc cacctcctga gatcctcacc tcttggaatt 3300 aaaattgttg gtcactgggg aaagcctgag tttgcaacca gttgtagggt ttctgttgtg 3360 tttttttttt tttttttgaa ataaaactat aatataaatt ctcctattaa ataaaattat 3420 tttaagtttt agtgtcaaaa gtgagatgct gagagtaggt gataatgtat attttacaga 3480 gtgggggttg gcaggatggt gacattgaac atgattgctc tctgtctctt ttttcagctt 3540 atgggtattt atcttctatt agtatttgta tcttcagttc attccacttt aggaaacaga 3600 gctgccaatt gaaacagaag aagaaaaaaa aaaaaagcag cagacaacac actgtagagt 3660 cttgcacaca cacaagtgcc caggcaaggt gcttggcaga accgcagagt gggaagagag 3720 taccggcatc gggtttcctt gggatcaatt tcattaccgt gtacctttcc cattgtggtc 3780 atgccatttg gcagggggag aatgggaggc ttggccttct ttgtgaggca gtgtgagcag 3840 aagctgatgc cagcatgtca ctggttttga agggatgagc ccagacttga tgttttggga 3900 ttgtccttat tttaacctca aggtctcgca tggtggggcc cctgaccaac ctacacaagt 3960 tccctcccac aagtggacat cagtgtcttc tctgtgaggc atctggccat tcgcactccc 4020 tggtgtggtc agcctctctc acacaaggag gaacttgggt gaaggctgag tgtgaggcac 4080 ctgaagtttc cctgcggagt cgataaatta gcagaaccac atccccatct gttaggcctt 4140 ggtgaggagg ccctgggcaa agaagggtct ttcgcaaagc gatgtcagag ggcggttttg 4200 agctttctat aagctatagc tttgtttatt tcacccgttc acttactgta taatttaaaa 4260 tcatttatgt agctgagaca cttctgtatt tcaatcatat catgaacatt ttattttgct 4320 aaatcttgtg tcatgtgtag gctgtaatat gtgtacattg tgtttaagag aaaaatgaaa 4380 cccacatgcc gccattttcc tgaatcaaat tctgcagtgg aatggagagg aaaatacttc 4440 taggcaagca gctagactgg tgaattgggg gaaatagaag gaactagtaa ctgagactcc 4500 tccagcctcc tccctattgg aatcccaatg gctcctggag taggaaaaaa gtttaaacta 4560 cattcatgtt cttgttctgt gtcactcggc cctgggtagt ctaccattta cttcacccca 4620 agtcctgctg cccatccagt tgggaagcca tgattttcct aagaatccag ggccatggga 4680 gatacaattc caagttctcg cttcctcctt tgggcatctc ttctgcctcc caatcaagga 4740 agctccatgc tcaggctctc agctctcggg ccagtgctct gctctgtcca gggtaggtaa 4800 tactgggaga ctcctgtctt ttaccctccc ctcgttccag acctgcctca tggtggcaac 4860 atggttcttg aacaattaaa gaaacaaatg actttttgga atagccctgt ctagggcaaa 4920 ctgtggcccc caggagacac tacccttcca tgccccagac ctctgtcttg catgtgacaa 4980 ttgacaatct ggactacccc aagatggcac ccaagtgttt ggcttctggc tacctaaggt 5040 taacatgtca ctagagtatt tttatgagag acaaacatta taaaaatctg atggcaaaag 5100 caaaacaaaa tggaaagtag gggaggtgga tgtgacaaca acttccaaat tggctctttg 5160 gaggcgagag gaaggggaga acttggagaa tagtttttgc tttgggggta gaggcttctt 5220 agattctccc agcatccgcc tttcccttta gccagtctgc tgtcctgaaa cccagaagtg 5280 atggagagaa accaacaaga gatctcgaac cctgtctaga aggaatgtat ttgttgctaa 5340 atttcgtagc actgtttaca gttttcctcc atgttattta tgaattttat attccgtgaa 5400 tgtatattgt cttgtaatgt tgcataatgt tcacttttta tagtgtgtcc tttattctaa 5460 acagtaaagt ggttttattt ctatcac 5487 <210> 17 <211> 4934 <212> DNA <213> Homo sapiens <400> 17 gcgagctgag ctgacagcgc ggagctggcg ctgtggagcg cagggagcct tgccggttcc 60 tccgaccggc gtctgcgagt acagcggcgg ctaacctgcc ccggcttcag gatttacaca 120 gacgtggggc gatgcttgtg accctgcagc tcctcaaacc agcctgtatt gagcggtttg 180 cagcctgatg ctcagccccc tccccacagg gcccctagaa gcctgtttct ccgtacagtc 240 caggacctcc agccccatgg agcccccgat cccacagagc gcccccttga ctcccaactc 300 agtcatggtc cagccccttc ttgacagccg gatgtcccac agccggctcc agcacccact 360 caccatccta cccattgacc aggtgaagac cagccatgtg gagaatgact acatagacaa 420 ccctagcctg gccctgacca ccggcccaaa gcggacccgg ggcggggccc cagagctggc 480 cccgacgccc gcccgctgtg accaggatgt cacccaccat tggatctcct tcagcgggcg 540 ccccagctct gtgagcagca gcagcagcac atcctctgac caacggctct tagaccacat 600 ggcaccacca cccgtggctg accaggcctc accaagggct gtgcgcatcc agcccaaggt 660 ggtccactgc cagccgctgg acctcaaggg cccggcggtc ccacccgagc tggacaagca 720 cttcttgctg tgcgaggcct gtgggaagtg taaatgcaag gagtgtgcat ccccccggac 780 gttgccttcc tgctgggtct gcaaccagga gtgcctgtgc tcagcccaga ctctggtcaa 840 ctatggcacg tgcatgtgtt tggtgcaggg catcttctac cactgcacga atgaggacga 900 tgagggctcc tgcgctgacc acccctgctc ctgctcccgc tccaactgct gcgcccgctg 960 gtccttcatg ggtgctctct ccgtggtgct gccctgcctg ctctgctacc tgcctgccac 1020 cggctgcgtg aagctggccc agcgtggcta cgaccgtctg cgccgccctg gttgccgctg 1080 caagcacacg aacagcgtca tctgcaaagc agccagcggg gatgccaaga ccagcaggcc 1140 cgacaagcct ttctgacagt ttgtgtcgaa gccccagtgc tctgcctgga aacctggttc 1200 tcttctgaca tctaagaaga ctgcagcaag gtcagaggtt ttagcctcct gaggctgacc 1260 ttgctagtct gcccactccc tacccccagc ttcggaaaat acagagacca ccaccacgta 1320 ccctgtattc cccaaggtga tgaagaagca ctttggggct ttttttcagg gtcctgaaac 1380 tttgtgtcaa acagacaatg caggggcagg gtgtggtttg gggggaaatt tttctttttc 1440 agaagacaga acacagatgt ggacacatat ccggaaactg cagctgcttg aatgccttcc 1500 cagcccctcc ttctccctcc ctccctccgc cccccccttc ctcttttcca ttgtctttgg 1560 ctctcacagg agctagctgc ctgggaggaa ttgttaactg agtaccaggg tacctttaaa 1620 gaagaccctt ggagtcttct ataccttctt ctccttcccc atctcactcc accccacttt 1680 gtccctgatg tcttggggaa ggtgtagaac accctagcag ttcctattgt atatacttgg 1740 gagccactga gaacagagga cggccagtga gtccaagcct cgttcctcct tctgcctccc 1800 cggagccaca ggatggattt aggagccact gctcagtgca cttctccctt ccaactgcat 1860 caactaactc tcgggggtgt tctgctcacc acaccgtcct tcggttctta ctgagtcaca 1920 gactcgcctg cccactacgt gtcctgggtt ctctactcag atcccttcca gaaactttat 1980 atgggtagag gaagccaggg cggcaaatgc gagaccaaat atcattttgc caatgagtct 2040 gaggctgtgg tctctggatc cagtcattat gtttttatag aataattaaa ccggatgcta 2100 acggtgtttt aaaaaataat aataaaacaa cttgtttcct tttggccacc cccaggaagg 2160 gctgatttca aaatctgggg gcgagcaacc tcaaggaaca caatttccct ccctatcaac 2220 aagaggattt taacagcaaa gaagagaggc agcacctccc attggcagaa tgaccgctga 2280 gccaggctgg gtttgggttt cttctcttct gattctgctg ctcactgtca tagccttttg 2340 tgtatagtga tgtgtctgta tctttaatgt aaatagagag atgatgaaaa aagagtctat 2400 tttagtgtta ggaagcccca gcaggggagt cggaagagct tggaagagct ggggagaggg 2460 taggggaaag gtttttccag gggccactgg gtttgagccc tgcttctgtg cacagccaca 2520 ccaccctctc ccgacagccc tcaaagacgt agcaactctt tctctcaagg tgctaaagga 2580 ctcagaaggt gcagcacgtc cagtgggtag gtacttgttg catgcaaaag ctgtagtgta 2640 tctggtcctt cctccccagc ttttgtgtgg ggttcttgct ttgtgtggta ttttgttttc 2700 ccctctaatg agagggcatg gcctgagtca gaagagctac cccaggtgaa actggaagtg 2760 catgaggcag agcgtccgta gcatttccag tttgttctgt ataggacaga ggtgcctccg 2820 ggaaggaggc agcgaggtag gtagctatga taggcaccta atgcttctca aggacttatt 2880 ttttccttct tgaagactag tagtaacatc ttatgattta gagtaagttg attgtaacca 2940 taggtattta ttgattggag gaagggaggg tcatattatt ttcggcttta tttatgtaac 3000 atttgctagc ttataaaagg cgaatgtgaa atattgcatc tgcattttcc aaggctgatt 3060 cgtgtagcta cccttgccac agttgtgacg gatgtatgga tgttcttgaa catttcagaa 3120 ggagtggtag aaaaaaacac acattcagcc aaccacttat atgaattgaa tgtatcagaa 3180 gtgtactgaa gggactggag atggttttcc tcagatgagg gggccccaaa attgatagtg 3240 cacatctgca cgctttctgc gaggcctcag aacttttccc agggcccctc cctcaaattg 3300 tctccatggg aaacttgacc cagtggcaag ttgcactttg gtgatcttgg tggtctacac 3360 acccgttctg tggagagtcg atttacataa gctgtgtata cacacacaca cacacacaca 3420 cacacacaca cacacacacc cctaccccac actgactgtc taccgacaga gaccctattt 3480 cctggcaaac ggcctcctga accctgactt tttgtgtaca tacttgtaaa cacggatttt 3540 tctgggtttt ggtttgcttt ttcctttttt ccccctgccc ctgttctagc ttgttcttct 3600 tggtttgctt tcaacctgct tgatggatgt ctgcagagtg ctctctaaga gtccacctca 3660 gtgcctcgtg tgctcagtgg tcatgggaag gagcgaagga accatccttg gttctcccag 3720 cttggttgtg tagcaatccc tcagcattgt ttttctcagc ttcttggcaa aaattaaaac 3780 aacaacaaca acaacaacaa caacaacaaa cagaaggata aactggcttg cctgtggacc 3840 ctccccggct ctggggccag tcgagagcca ctgagggacc cagcactcag agacacaaca 3900 cacatgtgta gctgcttctg gctgagtgtg tttcctgtca ccaatggcct gtttggctgg 3960 acgatgcctc ggcttgacct tttttgaaaa gtgctggtta gttcccgccc cctggtaaac 4020 ctggggtagg tgggggttct gtcttaactc gaggggcacc tgggatccag gacgcttcta 4080 gggggctctg gctgcccgtg ttaatgaagg acagcgcttc cgcgagcacc ctgggaactg 4140 ggtcttgggt agcaaagccc tcccagagaa aagatgggca caactaaggc tttcctgagc 4200 aggaaggggg tgaagaccaa tcccttcctt tggtcctttg gtacgcaccc cctcagagct 4260 gagatggaag acatggctag ttcttttcag ccttgtggag cctgtcagtc gccatcatac 4320 ctcgagtgag gcccagctag ataatgactt gtccaagatg gcacacgtgg aaagttgatc 4380 tgcaccagaa cccggatgac tgtcaccttg aagcgtcctg ttctccttct gtgctgtccc 4440 aggaagtgtc tggcgggcgt gggcagcaca gctctacact gtacgattca ctagggcatc 4500 ctgcgagcct cactagcctt ctggttcatg cctttgacaa gcatttttgt gccccctctg 4560 cttactgtga cagtcgatga tgaatcttgc gttgccattt tctgctgtgg gtaactgcgt 4620 gcagtgtctt gccttgcttt ctcttcttac tgtcccacag cttggtttca tgttacaaac 4680 agaaaagctc gaggctccca ccccgccaca tcccaacttc atttccccct cactgtagcc 4740 catttccacc ccaccacaaa gttgccacag gttttctttg tatagaatat ttattttgaa 4800 gctctatttt aatagtattt attttagaaa gtctactatt gtaagagttc ttctgtttgt 4860 gaagaaaaaa acaagttaaa aactgaatgt actgatttag aaaatatata taaatatata 4920 ttgttaaata taaa 4934 <210> 18 <211> 2038 <212> DNA <213> Homo sapiens <400> 18 atggagagct accacaagcc tgaccagcag aagctgcagg ccttgaagga cacggccaac 60 cgcctacgta tcagctccat ccaggccacc actgcggcgg gctctggcca ccccacgtca 120 tgctgcagcg ccgcagagat catggctgtc ctctttttcc acaccatgcg ctacaagtcc 180 caggaccccc ggaatccgca caatgaccgc tttgtgctct ccaagggcca tgcagctccc 240 atcctctacg cggtctgggc tgaagctggt ttcctggccg aggcggagct gctgaacctg 300 aggaagatca gctccgactt ggacgggcac ccggtcccga aacaagcttt caccgacgtg 360 gccactggct ccctgggcca gggcctcggg gccgcttgtg ggatggccta caccggcaaa 420 tacttcgaca aggccagcta ccgagtctat tgcttgctgg gagacgggga gctgtcagag 480 ggctctgtat gggaggccat ggccttcgcc agcatctata agctggacaa cctcgtggcc 540 attctagaca tcaatcgcct gggccagagt gacccggccc ctctgcagca ccagatggac 600 atctaccaga agcggtgcga ggccttcggt tggcatgcca tcatcgtgga tggacacagc 660 gtggaggagc tgtgcaaggc ctttggccag gccaagcacc agccaacagc catcattgcc 720 aagaccttca agggccgagg gatcacgggg gtagaagata aggagtcttg gcatgggaag 780 cccctcccca aaaacatggc tgagcagatc atccaggaga tctacagcca gatccagagc 840 aaaaagaaga tcctggcaac ccctccacag gaggacgcac cctcagtgga cattgccaac 900 atccgcatgc ccagcctgcc cagctacaaa gttggggaca agatagccac ccgcaaggcc 960 tacgggcagg cactggccaa gctgggccat gccagtgacc gcatcatcgc cctggatggg 1020 gacaccaaaa attccacctt ctcggagatc ttcaaaaagg agcacccgga ccgcttcatc 1080 gagtgctaca ttgctgagca gaacatggtg agcatcgcgg tgggctgtgc cacccgcaac 1140 aggacggtgc ccttctgcag cacttttgca gccttcttca cgcgggcctt tgaccagatt 1200 cgcatggccg ccatctccga gagcaacatt aacctctgcg gctcccactg cggcgtttcc 1260 atcggggaag acgggccctc ccagatggcc ctagaagatc tggctatgtt tcggtcagtc 1320 cccacatcaa ctgtctttta cccaagtgat ggcgttgcta cagagaaggc agtggaacta 1380 gccgccaata caaagggtat ctgcttcatc cggaccagcc gcccagaaaa tgccatcatc 1440 tataacaaca atgaggactt ccaggtcgga caagccaagg tggtcctgaa gagcaaggat 1500 gaccaggtga ccgttatcgg ggctggggtg accctgcacg aggccttggc cgctgccgaa 1560 ctgctgaaga aagaaaagat caacatccgc gtgctggacc ccttcaccat caagcccctg 1620 gacagaaaac tcattctcga cagcgctcgt gccaccaagg gcaggatcct caccgtggag 1680 gaccattatt atgaaggtgg cattggtgag gctgtgtcca gtgcagtagt gggcgagcct 1740 ggcatcactg tcacccacct ggcagttaac cgggtaccaa gaagtgggaa gccggctgag 1800 ctgctgaaga tgtttggtat cgacagggat gccattgcac aagctgtgag gggcctcatc 1860 accaaggcct agggcgggta tgaagtgtgg ggcgggggtc tatacattcc tgagattctg 1920 ggaaaggtgc tcaaagatgt actgagagga ggggtaaata tatgttttga gaaaaatgaa 1980 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2038 <210> 19 <211> 946 <212> DNA <213> Homo sapiens <400> 19 ggaaacccaa gaggaaatga ctgagcccgt ctgggtcccc gcccgctcgc gctcccctgg 60 ccacaccctc cgcctggacg cagcagccac cgccgcgtcc ctctctccac gaggctgccg 120 gcttaggacc cccagctccg acatgtcgcc ctctggtcgc ctgtgtcttc tcaccatcgt 180 tggcctgatt ctccccacca gaggacagac gttgaaagat accacgtcca gttcttcagc 240 agactcaact atcatggaca ttcaggtccc gacacgagcc ccagatgcag tctacacaga 300 actccagccc acctctccaa ccccaacctg gcctgctgat gaaacaccac aaccccagac 360 ccagacccag caactggaag gaacggatgg gcctctagtg acagatccag agacacacaa 420 gagcaccaaa gcagctcatc ccactgatga caccacgacg ctctctgaga gaccatcccc 480 aagcacagac gtccagacag acccccagac cctcaagcca tctggttttc atgaggatga 540 ccccttcttc tatgatgaac acaccctccg gaaacggggg ctgttggtcg cagctgtgct 600 gttcatcaca ggcatcatca tcctcaccag tggcaagtgc aggcagctgt cccggttatg 660 ccggaatcgt tgcaggtgag tccatcagaa acaggagctg acaacctgct gggcacccga 720 agaccaagcc ccctgccagc tcaccgtgcc cagcctcctg catcccctcg aagagcctgg 780 ccagagaggg aagacacaga tgatgaagct ggagccaggg ctgccggtcc gagtctccta 840 cctcccccaa ccctgcccgc ccctgaaggc tacctggcgc cttgggggct gtccctcaag 900 ttatctcctc tgctaagaca aaaagtaaag cactgtggtc tttgcc 946 <210> 20 <211> 1246 <212> DNA <213> Homo sapiens <400> 20 gaccagccta cagccgcctg catctgtatc cagcgccagg tcccgccagt cccagctgcg 60 cgcgcccccc agtcccgcac ccgttcggcc caggctaagt tagccctcac catgccggtc 120 aaaggaggca ccaagtgcat caaatacctg ctgttcggat ttaacttcat cttctggctt 180 gccgggattg ctgtccttgc cattggacta tggctccgat tcgactctca gaccaagagc 240 atcttcgagc aagaaactaa taataataat tccagcttct acacaggagt ctatattctg 300 atcggagccg gcgccctcat gatgctggtg ggcttcctgg gctgctgcgg ggctgtgcag 360 gagtcccagt gcatgctggg actgttcttc ggcttcctct tggtgatatt cgccattgaa 420 atagctgcgg ccatctgggg atattcccac aaggatgagg tgattaagga agtccaggag 480 ttttacaagg acacctacaa caagctgaaa accaaggatg agccccagcg ggaaacgctg 540 aaagccatcc actatgcgtt gaactgctgt ggtttggctg ggggcgtgga acagtttatc 600 tcagacatct gccccaagaa ggacgtactc gaaaccttca ccgtgaagtc ctgtcctgat 660 gccatcaaag aggtcttcga caataaattc cacatcatcg gcgcagtggg catcggcatt 720 gccgtggtca tgatatttgg catgatcttc agtatgatct tgtgctgtgc tatccgcagg 780 aaccgcgaga tggtctagag tcagcttaca tccctgagca ggaaagttta cccatgaaga 840 ttggtgggat tttttgtttg tttgttttgt tttgtttgtt gtttgttgtt tgtttttttg 900 ccactaattt tagtattcat tctgcattgc tagataaaag ctgaagttac tttatgtttg 960 tcttttaatg cttcattcaa tattgacatt tgtagttgag cggggggttt ggtttgcttt 1020 ggtttatatt ttttcagttg tttgtttttg cttgttatat taagcagaaa tcctgcaatg 1080 aaaggtacta tatttgctag actctagaca agatattgta cataaaagaa tttttttgtc 1140 tttaaataga tacaaatgtc tatcaacttt aatcaagttg taacttatat tgaagacaat 1200 ttgatacata ataaaaaatt atgacaatgt caaaaaaaaa aaaaaa 1246 <210> 21 <211> 829 <212> DNA <213> Homo sapiens <400> 21 tggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct agcgactgaa 60 gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa caggtggagg 120 tcttcagaca gaatcttttc caggaggctg aggaattcct ctacagattc ttgccacaga 180 aaatcatata cctgaatcag ctcttgcaag aggactccct caatgtggct gacttgactt 240 ccctccgggc cccactggac atccccatcc cagaccctcc acccaaggat gatgagatgg 300 aaacagataa gcaggagaag aaagaagtcc ataagtgtgg atttctccct gggaatgaga 360 aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa gagaaatgca 420 ttctggtgat tacatggatc caacacctga tccccaagat tgaagatgga aatgattttg 480 gggtagcaat ccaggagaag gtgctggaga gggtgaatgc cgtcaagacc aaagtggaag 540 ctttccagac aaccatttcc aagtacttct cagaacgtgg ggatgctgtg gccaaggcct 600 ccaaggagac tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct 660 atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag ctttatcata 720 tcatcagcag caacctggag aaaattgtca acccaaaggg tgaagaaaag ccatctatgt 780 actgaacccg ggactagaag gaaaataaat gatctatatg ttgtgtgga 829 <210> 22 <211> 3224 <212> DNA <213> Homo sapiens <400> 22 agcggtaaat ttgaaatggc tgacgggtcg ctgacgggcg gcggtctgga ggcagcggcc 60 atggcgccgg agcgcacggg ctgggcggtg gagcaggagc tggcgtctct ggagaaaggt 120 ttgttccaag atgaagattc atgcagtgat tgtagctacc gtgataaacc aggttctagt 180 ttacaaagtt ttatgccaga aggaaaaacc tttttcccag aaattttcca aacaaatcaa 240 cttttgttct atgagcgatt cagagcctat caagattaca ttttagctga ctgcaaggcc 300 tctgaggtac aggaattcac agctgagttc ttggagaagg tccttgagcc atctggatgg 360 cgggcagtct ggcacactaa tgtgttcaag gtgctggttg agatcacaga tgtggacttt 420 gcagccttga aggcagtggt gaggcttgct gaaccatacc tctgtgactc tcaagtgagc 480 acttttacca tggagtgcat gaaggagctc cttgatctga aggagcatcg gttgcccctg 540 caggagctgt gggtggtgtt tgatgattca ggagtgtttg accagacagc ccttgcaatt 600 gagcatgtca gatttttcta ccaaaacatt tggaggagtt gggatgaaga agaggaggat 660 gaatacgatt attttgtcag atgtgttgaa cctcgattaa gattgcatta tgacattctt 720 gaagaccgag ttccatcagg acttattgtt gactaccaca atctgttgtc tcaatgtgag 780 gagagttaca ggaaattttt aaatctgaga agcagtttgt caaattgtaa ctctgattcc 840 gagcaggaaa atatctccat ggtggaaggg ttaaaattgt attcggagat ggaacagttg 900 aaacaaaagc tgaaactcat tgagaatcct ttgttgaggt atgtgtttgg ttatcagaag 960 aattctaaca tccaagcaaa gggtgtccgt tccagcggtc agaagatcac tcatgtggtc 1020 tcctccacca tgatggctgg tctcctgcgg tccctgctta cggacaggct ttgccaggag 1080 cctggtgagg aagaaagaga aattcagttc catagtgatc cattgtctgc tataaatgcc 1140 tgcttcgaag gtgacactgt tattgtttgt cctggccatt atgtggtaca tggcactttc 1200 tccattgctg actccattga gttggaagga tatggcctac cagatgacat tgtgatagaa 1260 aagaggggca aaggcgacac ttttgtggac tgcactggtg ctgatattaa aatctcaggc 1320 ataaaatttg ttcagcatga tgctgtagag ggaatcttaa ttgttcaccg tggtaagact 1380 acgctggaaa actgtgtgct gcagtgtgag acgaccggag tcacagtgcg gacatcagca 1440 gagtttctaa tgaagaactc ggatttatat ggcgccaagg gtgctggtat agaaatctac 1500 cctgggagtc agtgcaccct gagtgacaat gggatccatc actgcaagga agggatcctc 1560 attaaggact tcttagatga acattatgac attcccaaga tatccatggt gaataatata 1620 atacataata atgaaggtta tggtgttgtc ttggtgaaac ctacaatctt ctctgacctg 1680 caagaaagtg ctgaagatgg aactgaagaa aataaagcgc ttaaaattca gacaagtgga 1740 gagccagatg tggctgaaag agtggatcta gaagagctga ttgagtgtgc aactggtaaa 1800 atggagcttt gtgcaagaac tgacccttct gagcaagtcg agggaaattg tgaaattgta 1860 aatgaactaa ttgctgcctc cacacagaaa ggccagataa agaagaaaag gttgagtgaa 1920 ctggggatca cgcaagctga tgacaactta atgtcacagg agatgtttgt tgggattgtg 1980 gggaaccagt tcaagtggaa tgggaaaggt agttttggca catttctttt ctgactacag 2040 tgatgtaagt agatagcaaa atactggatt ttgcacatgc tgccctaaga atcactgctg 2100 ccattgtagt ttgctgtatt gtctgtattt tatatttgat tatttgggct tgagtgaaag 2160 gtagatttat ttccatttgc aggtgttgca cataaaacac tccctcttta taagaaaaat 2220 cataaatgca tataaaatag aaaatatttg gagattgctt atctgaaagt cttgctttct 2280 tatacacatg gttctctcat attaagcctg gtggtaactt tttagtgtaa ttacctttag 2340 cacttcaaag acgaggaagt aaggaaggga atgcaagact agtgcataaa aatgcaatag 2400 gtgtcatatg tacagcattc ttcttagagt tgccttttca tcccaattac agtgagtctg 2460 atttccatcc tgtatttgca taatacttgt cttaaaataa aagcttttat gattgggaat 2520 ttatctgcct aatcagactt attattgaga cgtcaatggg acgcattttt ctgttgagct 2580 atgcagtcgt caaaacagcg atagacagca taggaggttt gaagcagaaa tgaaatgtgt 2640 tattcagagc caatgttgta catagagcat tttcactatt gctgaatggg aatgattaaa 2700 aacaaggtat ttttcgggcc aggcggtggc tcacgcttgt aatcgcagca ctttgggagg 2760 ctgaggcagg aggatcactt gagcccagga gttcaagact agcctaggca acatagtgag 2820 accctgtctc tactaaaaat aaatttaaaa aaaattagct gagtgtggtg gtgcatgcat 2880 gtagttccag ctactcagga ggctgaggct agaggatcct tgagcccagg aggttgaggc 2940 tgcagtgagg tgtgattgcg ccactgcatt ccagcttggg cgacagagcg agacccagtc 3000 tcaaaaaaaa aaaaagtatt tttctcttac cgttacagta ttctgattat attactgaca 3060 cagtcaaaat gattaactgt acaacctgta tctgctgggt gttcttgtta tcatattgta 3120 aaacagcttt aaaaatattt atattttaaa aactgtatgt gacattaata tgcctaatga 3180 ttaaaattat agtgatgaaa taacaaagaa aaaaaaaaaa aaaa 3224 <210> 23 <211> 5145 <212> DNA <213> Homo sapiens <400> 23 cgggcccctc gccactaccg ccgccgccgc cgccgtgagt cccgcggagc cgcgcgcgcc 60 cccggctggg ccgagccgct ggccgacgag cggagcctca ggagccggcg gggacgccat 120 gcgagccagc gtctcccttc tctcctggac agaaggccgt gtcctgggac ttctctgatg 180 gcgagaggct gcggctgtac caggaagaaa catattgccg agtggatgcc gccgcgcagc 240 gtgtttgctt gaggcagaag cttcagcatc tgctgggata actggaggaa gaaatatgaa 300 gccttagcgg ctttacccgg gaagcgagtt tcgagatggc ggctcagcgg atccgagcgg 360 ccaactccaa tggcctccct cgctgcaagt cagaggggac cctgattgac ctgagcgaag 420 ggttttcaga gacgagcttt aatgacatca aagtgccttc tcccagtgcc ttgctcgtag 480 acaaccccac acctttcgga aatgcaaagg aagtgattgc gatcaaggac tattgcccca 540 ccaacttcac cacactgaag ttctccaagg gcgaccatct ctacgtcttg gacacatctg 600 gcggtgagtg gtggtacgca cacaacacca ccgaaatggg ctacatcccc tcctcctatg 660 tgcagccctt gaactaccgg aactcaacac tgagtgacag cggtatgatt gataatcttc 720 cagacagccc agacgaggta gccaaggagc tggagctgct cgggggatgg acagatgaca 780 aaaaagtacc aggcagaatg tacagtaata accctttctg gaatggggtc cagaccaatc 840 catttctgaa tgggaacgtg cccgtcatgc ccagcctgga tgagctgaat cccaaaagta 900 ctgtggattt gctccttttt gacgcaggta catcctcctt caccgaatcc agctcagcca 960 ccacgaatag cactggcaac atcttcgatg agcttccagt cacaaacgga ctccacgcag 1020 agccgccggt caggcgggac aaccccttct tcagaagcaa gcgctcctac agtctctcgg 1080 aactctccgt cctccaagcc aagtccgatg ctcccacatc gtcgagtttc ttcaccggct 1140 tgaaatcacc tgcccccgag caatttcaga gccgggagga ttttcgaact gcctggctaa 1200 accacaggaa gctggcccgg tcttgccacg acctggactt gcttggccaa agccctggtt 1260 ggggccagac ccaagccgtg gagacaaaca tcgtgtgcaa gctggatagc tccgggggtg 1320 ctgtccagct tcctgacacc agcatcagca tccacgtgcc cgagggccac gtcgcccctg 1380 gggagaccca gcagatctcc atgaaagccc tgctggaccc cccgctggag ctcaacagtg 1440 acaggtcctg cagcatcagc cctgtgctgg aggtcaagct gagcaacctg gaggtgaaaa 1500 cctctatcat cttggagatg aaagtgtcag ccgagataaa aaatgacctt tttagcaaaa 1560 gcacagtggg cctccagtgc ctgaggagcg actcgaagga agggccatat gtctccgtcc 1620 cgctcaactg cagctgtggg gacacggtcc aggcacagct gcacaacctg gagccctgta 1680 tgtacgtggc tgtcgtggcc catggcccaa gcatcctcta cccttccacc gtgtgggact 1740 tcatcaataa aaaagtcaca gtgggtctct acggccctaa acacatccac ccatccttca 1800 agacggtagt gaccattttt gggcatgact gtgccccaaa gacgctcctg gtcagcgagg 1860 tcacacgcca ggcacccaac cctgccccgg tggccctgca gctgtggggg aagcaccagt 1920 tcgttttgtc caggccccag gatctcaagg tctgtatgtt ttccaatatg acgaattacg 1980 aggtcaaagc cagcgagcag gccaaagtgg tgcgaggatt ccagctgaag ctgggcaagg 2040 tgagccgcct gatcttcccc atcacctccc agaaccccaa cgagctctct gacttcacgc 2100 tgcgggttca ggtgaaggac gaccaggagg ccatcctcac ccagttttgt gtccagactc 2160 ctcagccacc ccctaaaagt gccatcaagc cttccgggca aaggaggttt ctcaagaaga 2220 acgaagtcgg gaaaatcatc ctgtccccgt ttgccaccac tacaaagtac ccgactttcc 2280 aggaccgccc ggtgtccagc ctcaagtttg gtaagttgct caagactgtg gtgcggcaga 2340 acaagaacca ctacctgctg gagtacaaga agggcgacgg gatcgccctg ctcagcgagg 2400 agcgggtcag gctccggggc cagctgtgga ccaaggagtg gtacatcggc tactaccagg 2460 gcagggtggg cctcgtgcac accaagaacg tgctggtggt cggcagggcc cggcccagcc 2520 tgtgctcggg ccccgagctg agcacctcgg tgctgctgga gcagatcctg cggccctgca 2580 aattcctcac gtacatctat gcctccgtga ggaccctgct catggagaac atcagcagct 2640 ggcgctcctt cgctgacgcc ctgggctacg tgaacctgcc gctcaccttt ttctgccggg 2700 cagagctgga tagtgagccc gagcgggtgg cgtccgtcct agaaaagctg aaggaggact 2760 gtaacaacac tgagaacaaa gaacggaagt ccttccagaa ggagcttgtg atggccctac 2820 tgaagatgga ctgccagggc ctggtggtca gactcatcca ggactttgtg ctcctgacca 2880 cggctgtaga ggtggcccag cgctggcggg agctggctga gaagctggcc aaggtctcca 2940 agcagcagat ggacgcctac gagtctcccc accgggacag gaacggggtt gtggacagcg 3000 aggccatgtg gaagcctgcg tatgacttct tactcacctg gagccatcag atcggggaca 3060 gctaccggga tgtcatccag gagctgcacc tgggcctgga caagatgaaa aaccccatca 3120 ccaagcgctg gaagcacctc actgggactc tgatcttggt gaactccctg gacgttctga 3180 gagcagccgc cttcagccct gcggaccagg acgacttcgt gatttgaatg ggtcccctcc 3240 cctcctgctg ctctggagtg caagccctct tctgccctgc gtgccctgct gtcaccgcgg 3300 agctgaagag ggaggaaggg gcggctgctc agacagattt agggcccgcc agctaggcta 3360 cacccatcat gcgccgccct cctccatcga gggagaggcc tgaagggact gcctactgca 3420 gctcgttgcc aatcacatag ctttctattt gttaagtata aatttaaatt taaaatcact 3480 tttttaacga atggggggaa gggatctatg agaaaggtgg tatctaattt ttttatggac 3540 cataaaggtt taaaagaaaa taggggcaca ggctgttgag gtttttatgt tgttatagac 3600 ctttttaaat tatgttagag atgtatatag gtatttaaag gtcactggga gcgtttctga 3660 ttcccggcca cactttgcat ttcaacactc agcccggaaa gatgctcgtt cggttgttgg 3720 acctctttca ctccctgcgt gtaagaaggt gaatcacgtg ggaaaaagtg gcttttcagt 3780 aaacgggtac agctcattct ttctgagaag gccccaggtc ctgctccctc ctcggatttg 3840 attgtcttcc gtgctttgcc tcactcgtag taaatgacca tccatagaat atgtgaatct 3900 ttggtgagct tcagtgggca gagtgaagtc ccgcattagc atttaggtgc cctgagctgt 3960 ttctgccaat agattagaaa gcagccatga gttgacagtc tttagggccc ctgccagtgt 4020 gcaattagtc attgacaaga acaatgccat ttgagagtga ggtggtccct gctgctacga 4080 ggccattgta ctgttttttc cttgaggtca aagcagtgct tcccatagag tttgctgcct 4140 cttctgtgga caggaagaaa acttcatgac cgaatcagag ccttggtggc cactgactct 4200 cgtgcttatt gcagatgctg tggttggcct cacaagcaac gccttatgct gatgtgcaga 4260 ggtgccagct gccatttgcc aaactctgca tttcatttca tctaaggctt aacccctctt 4320 ccttcctggt gtacctgtgt ctcctcggaa ggaagtcata gtttagatga aaccattttt 4380 tgtacaatgt aaagatcatc tgagcaagat gagcattttg taaaaatgaa aatgtgactc 4440 acataaaatc aggaacttga cacagtgttg cattaataac tttagggtgc agacatgctg 4500 tgtgaatctc acaatgcgtc gtagatgtcg cgtgttggaa gggagcagga ggaaggactg 4560 atactggcaa atcagtagag tgaggtgatc cttagcaacg tgccaggaca cttcctgtgt 4620 gcctgcagtt gtcagggacc atttgggatc ccgaatctca ttctctaaaa ctgctttctt 4680 gaaacatgtt acttccttag tataatcaat gtatactccc ttactggcct gaaacgttgt 4740 atagctactt attcagatac tgaagaccaa cggactgaaa aaaagaacaa acattagcta 4800 ttttatgctg caagaaccag gacacacaat tcgccaatca tcccaccata taaccttcga 4860 ttgtgcttct caactccacc ccataatttc tcccagagac catctatcac cttttcccca 4920 aagaagaaac aaaaccagtt gcaccttaaa ccatggatat tttttcctca ggggctttaa 4980 atagtttcct atgcaacgtg tcttgtagca caaataaaat tctacaaaag ttgcagtaaa 5040 ttttatttgg atattttaac ctgttaagtg tgtgtgtgtt ttctgtaccc aaccagactt 5100 taaataaaac aaacatgaaa cctaaaaaaa aaaaaaaaaa aaaaa 5145 <210> 24 <211> 2749 <212> DNA <213> Homo sapiens <400> 24 gcacaaacaa gctggagcag cccagaggac aagaattttg ggcagatttg aatgccatga 60 acgtgtatga aacaactgaa tttgaccaac tacgaaggct gtccacacca ccctctagca 120 atgtcaactc tatttaccac acagtctgga aattcttctg tagggaccac tttggatgga 180 gagagtatcc cgagtctgtc attcgattga ttgaagaagc caactctcgg ggtctgaaag 240 aggttcgatt tatgatgtgg aataaccact acatcctcca caattcattc ttcaggagag 300 agataaaaag gagacccctc ttccgctcct gttttatact gcttccatat ttacagacac 360 ttggtggggt tcccacacaa gctcctccac ctcttgaagc aacttcatca tcacaaatta 420 tctgcccaga tggggtcact tcagcaaact tttaccctga aacttgggtt tatatgcatc 480 catctcagga cttcatccaa gtccctgttt ctgcagagga taaaagttat cggatcattt 540 acaatctttt tcataagact gtgcctgagt ttaaatacag aattttgcag atattgagag 600 tccaaaacca gtttctttgg gagaaatata aaaggaaaaa ggaatatatg aacaggaaaa 660 tgtttggccg tgacaggata ataaatgaga gacatttatt tcatggaaca tcccaggatg 720 tggtagatgg aatctgcaaa cacaactttg accctcgagt ctgtggaaag catgctacaa 780 tgtttggaca aggcagttat tttgcaaaga aggcaagcta ctctcataac ttttctaaga 840 agtcctccaa aggagtccac ttcatgtttc tggccaaagt gctgacgggc agatacacaa 900 tgggcagtca tggcatgaga aggcccccgc cagtcaatcc tggcagtgtc accagtgacc 960 tttatgactc ttgtgtggat aatttctttg agcctcagat ttttgtcatt tttaatgatg 1020 accagagtta cccttatttt gttatccaat atgaagaagt cagtaacact gtttccattt 1080 gaaaaatctt ggtactgcta aattatttga tatgaactca atccagcatt tgtagcaggt 1140 tttgaatggg tgggactggg tggggaacag cattggacat taatagggca cttttcagac 1200 ccatttttta aagtgctaga aaatgctttt ttttaaaaaa aaatacaagt tttaaaatga 1260 ccacttactc tttaattatt tactaattgc tagtgtactc agtgtggaaa agactacaga 1320 ttacacactc ttttcattca cacttgtaca tatagacagc aatgttatta ggagcattaa 1380 attaaaaaac tgaacagcct aatttaaatg tggcttgggc ctggtagaag tttgaccaaa 1440 tggaatggag gctgtgagca atgtgaggat tctatttatt tatttacgtt tgataaaact 1500 tactggaact agtactacca tgcgtattcc ctgtccaaag catcactgct ttggtatagt 1560 ataagttcat gaaattctgg tgggtagaaa gaaattttta tttctatcag cagtactaaa 1620 atgtatcagc caaccagaga acatcagtga ctttaacttc tgcagagttt gccccagaat 1680 tcagagttct atttagagga agttaaaaca acaacaaaaa acaaccattt gaaaaatttt 1740 tgtcaccagc aaaacttttc actaattagt gatatgaaat gtgatttttg tgttgttaaa 1800 cttcagcttt ggaaaactca gtctctttca ttatcatcca ttccaatttg aaggagttgg 1860 gcagctaatt tggttaaagg cagtcttgag ggttagaagt attacttcct tttcgggttc 1920 cagacctagc ttgtgactga aagttttaga aaaaggaagt acatctatag ccgaattgat 1980 aaggttatta ctgtgttttg cacaaagtat attagcaaaa gtatttgctg gaattattgg 2040 tagatggcag tcccactcct acacctgctt tgtcagatac agctgggttc cctggctgac 2100 tctgtacctt acttacacta cttacttaat agaaacacaa acttggaaat tgtgccagtg 2160 gtccagctgg agcacaacgt ttggtgaata tgctgtttcc tcagttcaga gaggtagcaa 2220 ctaggtaaac tccttataaa aagcaaatac ctggatttac aaaagtgaaa gtagttgttc 2280 acaaaagaat tcgccatgga attctttcag ttaccaagct ctcctggtaa tgtttgtggt 2340 tatatcattt acacaaaact tttcaggaac ttctgtgttg tttaagcaag atgtatctgt 2400 actgatgtct cagtgaatca gtctgtttat taagcactta tcagggcttc cacacactta 2460 tttattttgc cctagttaat cctgttgttt gctgccattg gcatgaaatg gccaactgtg 2520 gctgttacag ttctttcatt caattataac ttgtaaacca gtgactccta atctttttca 2580 agttaagaca ccttaccatt gcttatttgg ttttatgaga cttgttcctt tttttctccc 2640 taaggaaaaa gaaagcttta tgacatattt atttttttaa taaaactaag caaaaataaa 2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2749 <210> 25 <211> 2358 <212> DNA <213> Homo sapiens <400> 25 gagtcctcag ctctccctac tccacgctgc ctagacatac acagctgcag ggtctggctg 60 aacaatcaag gggccgccag agaaaggcca tctacggtgc gcagtgtatc tggagttgct 120 gggcccaaga tagctctgtg gagttatcac tagagatgcc tctggattaa ctaagaggtg 180 tgcctgggtg tgggtgagga gtcagaacct ttgagagctt tgagatgaca gtttctatgg 240 ggcgggaaga aggaggtgca tttctacaaa cacttccctg aaatccttgg gaaaaacaga 300 ggcatggccg tggccaactc tgtgggaact ggcgcctctg tccttgttgg cactgttctc 360 agtccgatga cttgcattgt gttttctcca atttttgctg ggattttaat gttcagcatg 420 gtgggaggaa cccttgattc cttttgtttg agtatagaaa gtaaattttt gaggtcatga 480 tgtgaacggc catgttattg tgattatctt cagctcagga taggctgaga tgctttgtgg 540 agtgttccat gaagcccgag tcggaatctc tgactgtcgt gtacagccat aaggagactg 600 gtttgaatta ctgtggcgag acagggcgtg cctgtcagaa atctgagatg tttgtacgct 660 ctgagatgtt gaacctttct ggtgggcagc accgacaccc aggggtggac ccccgaggat 720 gaatgcctct aggcctccgc aacatattca agaatgaatg ggagacgcta gagtaaaatg 780 ggggcagaga ggatatcagg gagcaagatg caaactgtgt gcatccactc tcgtaaacaa 840 gtagctggtc acaaccagaa aggttcatct ctcctaagca aacagcgact ctttcagagg 900 aagtttccct ctttcaatcg tggccttatt ttcaactccg gtgccttctc gtgatgttaa 960 tcatttcctt ttttccccac actaagctct cttttctatc tttctctctc tttccaatct 1020 tacgccatgg ccatcagttc atttcagcct tccagtgcta cacccacttc ttggctgaca 1080 cacttctgct ctaaggtgac tggttttctt gccaattttc aaagagtggt actaaccccc 1140 aacccgcttt ccgcaccccg tcctctccgc cagcagtact ggttgcacta actgtgagtg 1200 tcttgcatac tgatggactc atttggtggc atggttggct aacagcatgg cggggggtgt 1260 tcagcttgag acccatgcct gtgttcattt cccatggagc tggcagcctg gtctacccca 1320 agtgcatgcc ccgcctctcc tctctccctt gggtctgcct gcgtgcatgc ttctccagtt 1380 gcgtctgcga agctacctac tttcttggga gggtcgacct tgatcatgaa acaataccat 1440 gagggggcct ctgtcacctt tgaaaagaac actttttgag cagcctcaaa aagctcatac 1500 ataccagcgc cttcttaaat tggctctaat gtaaagattg ttaatgtcat ttatcaaaac 1560 cataggtgat tatttggagg gatttaaaaa acttaattac tctcaggcct catcccaagc 1620 ttgacacatg ctctgtaggt tgaacacata atcacaaata ttctagcaaa tgctgccttg 1680 gttgcagcct gcactgtaga cccaagggtt ttgctgtggc tcttcttatc tcccttggct 1740 cataaagccc cagatgatgc cagagcttca attagagcca tcatcatccc aggcagggat 1800 atctttgaga aatgactcag ttcagcccca ggcccctgtg actctgctta aagcacacat 1860 ttctgctgac tcttgtacct ggggcagcag gataatcacc aacacactct taacgagaaa 1920 caacacacca agcacagtgg agctgtccta ggcaacactc gcggtctcag gctgcggtgg 1980 gcgtctgtcc tgcatgtggc ccagaccacc ctgacccccg ggcctgcctg cctggccctg 2040 catgctgcac gctcactgta tttgtgcaga tcctggccag tacaaagtcg ttgctcttgt 2100 cttatcttct cttacagagt ctccctccct ttatagaatg tcaaccaaag agtgccctcc 2160 tcccctctca gcctcctctt tagctagcct ccccatctca tcacaacgca tgtctgtgac 2220 ctttggtaat catttacagt gccacacgga accctgtatt ttgcacacag caaaacaaac 2280 aatgtttagc tttatttatg gtatttgatg ctgtaaatgg aaataaatat tgttctttat 2340 aaaaaaaaaa aaaaaaaa 2358 <210> 26 <211> 2944 <212> PRT <213> Homo sapiens <400> 26 Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 1 5 10 15 Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 20 25 30 Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 35 40 45 Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 50 55 60 Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 65 70 75 80 Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 85 90 95 Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 100 105 110 Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 115 120 125 His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 130 135 140 Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 145 150 155 160 Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 165 170 175 Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 180 185 190 Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 195 200 205 Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 210 215 220 Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 225 230 235 240 Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 245 250 255 Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 260 265 270 Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 275 280 285 Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 290 295 300 Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 305 310 315 320 Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 325 330 335 Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 340 345 350 Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 355 360 365 Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 370 375 380 Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 385 390 395 400 Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 405 410 415 Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 420 425 430 Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 435 440 445 Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 450 455 460 Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 465 470 475 480 Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 485 490 495 Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 500 505 510 Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 515 520 525 Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 530 535 540 Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 545 550 555 560 Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 565 570 575 Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 580 585 590 Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 595 600 605 Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 610 615 620 Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 625 630 635 640 Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 645 650 655 Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 660 665 670 Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 675 680 685 Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 690 695 700 Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 705 710 715 720 Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 725 730 735 Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 740 745 750 Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 755 760 765 Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 770 775 780 Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 785 790 795 800 Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 805 810 815 Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 820 825 830 Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 835 840 845 Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 850 855 860 Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 865 870 875 880 His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 885 890 895 Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 900 905 910 Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 915 920 925 Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 930 935 940 Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 945 950 955 960 Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 965 970 975 Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 980 985 990 Arg Gly Pro Gly Gln Glu Val Pro Gly Ser Pro Gln Thr Leu Pro Gly 995 1000 1005 Ile Ser Ser Ser Gln Arg Val Thr Gly Leu Glu Pro Gly Val Ser Tyr 1010 1015 1020 Ile Phe Ser Leu Thr Pro Val Leu Asp Gly Val Arg Gly Pro Glu Ala 1025 1030 1035 1040 Ser Val Thr Gln Thr Pro Val Cys Pro Arg Gly Leu Ala Asp Val Val 1045 1050 1055 Phe Leu Pro His Ala Thr Gln Asp Asn Ala His Arg Ala Glu Ala Thr 1060 1065 1070 Arg Arg Val Leu Glu Arg Leu Val Leu Ala Leu Gly Pro Leu Gly Pro 1075 1080 1085 Gln Ala Val Gln Val Gly Leu Leu Ser Tyr Ser His Arg Pro Ser Pro 1090 1095 1100 Leu Phe Pro Leu Asn Gly Ser His Asp Leu Gly Ile Ile Leu Gln Arg 1105 1110 1115 1120 Ile Arg Asp Met Pro Tyr Met Asp Pro Ser Gly Asn Asn Leu Gly Thr 1125 1130 1135 Ala Val Val Thr Ala His Arg Tyr Met Leu Ala Pro Asp Ala Pro Gly 1140 1145 1150 Arg Arg Gln His Val Pro Gly Val Met Val Leu Leu Val Asp Glu Pro 1155 1160 1165 Leu Arg Gly Asp Ile Phe Ser Pro Ile Arg Glu Ala Gln Ala Ser Gly 1170 1175 1180 Leu Asn Val Val Met Leu Gly Met Ala Gly Ala Asp Pro Glu Gln Leu 1185 1190 1195 1200 Arg Arg Leu Ala Pro Gly Met Asp Ser Val Gln Thr Phe Phe Ala Val 1205 1210 1215 Asp Asp Gly Pro Ser Leu Asp Gln Ala Val Ser Gly Leu Ala Thr Ala 1220 1225 1230 Leu Cys Gln Ala Ser Phe Thr Thr Gln Pro Arg Pro Glu Pro Cys Pro 1235 1240 1245 Val Tyr Cys Pro Lys Gly Gln Lys Gly Glu Pro Gly Glu Met Gly Leu 1250 1255 1260 Arg Gly Gln Val Gly Pro Pro Gly Asp Pro Gly Leu Pro Gly Arg Thr 1265 1270 1275 1280 Gly Ala Pro Gly Pro Gln Gly Pro Pro Gly Ser Ala Thr Ala Lys Gly 1285 1290 1295 Glu Arg Gly Phe Pro Gly Ala Asp Gly Arg Pro Gly Ser Pro Gly Arg 1300 1305 1310 Ala Gly Asn Pro Gly Thr Pro Gly Ala Pro Gly Leu Lys Gly Ser Pro 1315 1320 1325 Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Glu Arg Gly Pro Arg Gly 1330 1335 1340 Pro Lys Gly Glu Pro Gly Ala Pro Gly Gln Val Ile Gly Gly Glu Gly 1345 1350 1355 1360 Pro Gly Leu Pro Gly Arg Lys Gly Asp Pro Gly Pro Ser Gly Pro Pro 1365 1370 1375 Gly Pro Arg Gly Pro Leu Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly 1380 1385 1390 Leu Pro Gly Thr Ala Met Lys Gly Asp Lys Gly Asp Arg Gly Glu Arg 1395 1400 1405 Gly Pro Pro Gly Pro Gly Glu Gly Gly Ile Ala Pro Gly Glu Pro Gly 1410 1415 1420 Leu Pro Gly Leu Pro Gly Ser Pro Gly Pro Gln Gly Pro Val Gly Pro 1425 1430 1435 1440 Pro Gly Lys Lys Gly Glu Lys Gly Asp Ser Glu Asp Gly Ala Pro Gly 1445 1450 1455 Leu Pro Gly Gln Pro Gly Ser Pro Gly Glu Gln Gly Pro Arg Gly Pro 1460 1465 1470 Pro Gly Ala Ile Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Leu 1475 1480 1485 Gly Glu Ala Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Pro Ala Gly 1490 1495 1500 Ser Arg Gly Leu Pro Gly Val Ala Gly Arg Pro Gly Ala Lys Gly Pro 1505 1510 1515 1520 Glu Gly Pro Pro Gly Pro Thr Gly Arg Gln Gly Glu Lys Gly Glu Pro 1525 1530 1535 Gly Arg Pro Gly Asp Pro Ala Val Val Gly Pro Ala Val Ala Gly Pro 1540 1545 1550 Lys Gly Glu Lys Gly Asp Val Gly Pro Ala Gly Pro Arg Gly Ala Thr 1555 1560 1565 Gly Val Gln Gly Glu Arg Gly Pro Pro Gly Leu Val Leu Pro Gly Asp 1570 1575 1580 Pro Gly Pro Lys Gly Asp Pro Gly Asp Arg Gly Pro Ile Gly Leu Thr 1585 1590 1595 1600 Gly Arg Ala Gly Pro Pro Gly Asp Ser Gly Pro Pro Gly Glu Lys Gly 1605 1610 1615 Asp Pro Gly Arg Pro Gly Pro Pro Gly Pro Val Gly Pro Arg Gly Arg 1620 1625 1630 Asp Gly Glu Val Gly Glu Lys Gly Asp Glu Gly Pro Pro Gly Asp Pro 1635 1640 1645 Gly Leu Pro Gly Lys Ala Gly Glu Arg Gly Leu Arg Gly Ala Pro Gly 1650 1655 1660 Val Arg Gly Pro Val Gly Glu Lys Gly Asp Gln Gly Asp Pro Gly Glu 1665 1670 1675 1680 Asp Gly Arg Asn Gly Ser Pro Gly Ser Ser Gly Pro Lys Gly Asp Arg 1685 1690 1695 Gly Glu Pro Gly Pro Pro Gly Pro Pro Gly Arg Leu Val Asp Thr Gly 1700 1705 1710 Pro Gly Ala Arg Glu Lys Gly Glu Pro Gly Asp Arg Gly Gln Glu Gly 1715 1720 1725 Pro Arg Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly Ala Pro Gly Glu 1730 1735 1740 Arg Gly Ile Glu Gly Phe Arg Gly Pro Pro Gly Pro Gln Gly Asp Pro 1745 1750 1755 1760 Gly Val Arg Gly Pro Ala Gly Glu Lys Gly Asp Arg Gly Pro Pro Gly 1765 1770 1775 Leu Asp Gly Arg Ser Gly Leu Asp Gly Lys Pro Gly Ala Ala Gly Pro 1780 1785 1790 Ser Gly Pro Asn Gly Ala Ala Gly Lys Ala Gly Asp Pro Gly Arg Asp 1795 1800 1805 Gly Leu Pro Gly Leu Arg Gly Glu Gln Gly Leu Pro Gly Pro Ser Gly 1810 1815 1820 Pro Pro Gly Leu Pro Gly Lys Pro Gly Glu Asp Gly Lys Pro Gly Leu 1825 1830 1835 1840 Asn Gly Lys Asn Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Arg Lys 1845 1850 1855 Gly Glu Lys Gly Asp Ser Gly Ala Ser Gly Arg Glu Gly Arg Asp Gly 1860 1865 1870 Pro Lys Gly Glu Arg Gly Ala Pro Gly Ile Leu Gly Pro Gln Gly Pro 1875 1880 1885 Pro Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Gln Gly Phe Pro Gly 1890 1895 1900 Val Pro Gly Gly Thr Gly Pro Lys Gly Asp Arg Gly Glu Thr Gly Ser 1905 1910 1915 1920 Lys Gly Glu Gln Gly Leu Pro Gly Glu Arg Gly Leu Arg Gly Glu Pro 1925 1930 1935 Gly Ser Val Pro Asn Val Asp Arg Leu Leu Glu Thr Ala Gly Ile Lys 1940 1945 1950 Ala Ser Ala Leu Arg Glu Ile Val Glu Thr Trp Asp Glu Ser Ser Gly 1955 1960 1965 Ser Phe Leu Pro Val Pro Glu Arg Arg Arg Gly Pro Lys Gly Asp Ser 1970 1975 1980 Gly Glu Gln Gly Pro Pro Gly Lys Glu Gly Pro Ile Gly Phe Pro Gly 1985 1990 1995 2000 Glu Arg Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Pro Gln Gly Pro 2005 2010 2015 Pro Gly Leu Ala Leu Gly Glu Arg Gly Pro Pro Gly Pro Ser Gly Leu 2020 2025 2030 Ala Gly Glu Pro Gly Lys Pro Gly Ile Pro Gly Leu Pro Gly Arg Ala 2035 2040 2045 Gly Gly Val Gly Glu Ala Gly Arg Pro Gly Glu Arg Gly Glu Arg Gly 2050 2055 2060 Glu Lys Gly Glu Arg Gly Glu Gln Gly Arg Asp Gly Pro Pro Gly Leu 2065 2070 2075 2080 Pro Gly Thr Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Val Ser Val 2085 2090 2095 Asp Glu Pro Gly Pro Gly Leu Ser Gly Glu Gln Gly Pro Pro Gly Leu 2100 2105 2110 Lys Gly Ala Lys Gly Glu Pro Gly Ser Asn Gly Asp Gln Gly Pro Lys 2115 2120 2125 Gly Asp Arg Gly Val Pro Gly Ile Lys Gly Asp Arg Gly Glu Pro Gly 2130 2135 2140 Pro Arg Gly Gln Asp Gly Asn Pro Gly Leu Pro Gly Glu Arg Gly Met 2145 2150 2155 2160 Ala Gly Pro Glu Gly Lys Pro Gly Leu Gln Gly Pro Arg Gly Pro Pro 2165 2170 2175 Gly Pro Val Gly Gly His Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly 2180 2185 2190 Leu Ala Gly Pro Ala Gly Pro Gln Gly Pro Ser Gly Leu Lys Gly Glu 2195 2200 2205 Pro Gly Glu Thr Gly Pro Pro Gly Arg Gly Leu Thr Gly Pro Thr Gly 2210 2215 2220 Ala Val Gly Leu Pro Gly Pro Pro Gly Pro Ser Gly Leu Val Gly Pro 2225 2230 2235 2240 Gln Gly Ser Pro Gly Leu Pro Gly Gln Val Gly Glu Thr Gly Lys Pro 2245 2250 2255 Gly Ala Pro Gly Arg Asp Gly Ala Ser Gly Lys Asp Gly Asp Arg Gly 2260 2265 2270 Ser Pro Gly Val Pro Gly Ser Pro Gly Leu Pro Gly Pro Val Gly Pro 2275 2280 2285 Lys Gly Glu Pro Gly Pro Thr Gly Ala Pro Gly Gln Ala Val Val Gly 2290 2295 2300 Leu Pro Gly Ala Lys Gly Glu Lys Gly Ala Pro Gly Gly Leu Ala Gly 2305 2310 2315 2320 Asp Leu Val Gly Glu Pro Gly Ala Lys Gly Asp Arg Gly Leu Pro Gly 2325 2330 2335 Pro Arg Gly Glu Lys Gly Glu Ala Gly Arg Ala Gly Glu Pro Gly Asp 2340 2345 2350 Pro Gly Glu Asp Gly Gln Lys Gly Ala Pro Gly Pro Lys Gly Phe Lys 2355 2360 2365 Gly Asp Pro Gly Val Gly Val Pro Gly Ser Pro Gly Pro Pro Gly Pro 2370 2375 2380 Pro Gly Val Lys Gly Asp Leu Gly Leu Pro Gly Leu Pro Gly Ala Pro 2385 2390 2395 2400 Gly Val Val Gly Phe Pro Gly Gln Thr Gly Pro Arg Gly Glu Met Gly 2405 2410 2415 Gln Pro Gly Pro Ser Gly Glu Arg Gly Leu Ala Gly Pro Pro Gly Arg 2420 2425 2430 Glu Gly Ile Pro Gly Pro Leu Gly Pro Pro Gly Pro Pro Gly Ser Val 2435 2440 2445 Gly Pro Pro Gly Ala Ser Gly Leu Lys Gly Asp Lys Gly Asp Pro Gly 2450 2455 2460 Val Gly Leu Pro Gly Pro Arg Gly Glu Arg Gly Glu Pro Gly Ile Arg 2465 2470 2475 2480 Gly Glu Asp Gly Arg Pro Gly Gln Glu Gly Pro Arg Gly Leu Thr Gly 2485 2490 2495 Pro Pro Gly Ser Arg Gly Glu Arg Gly Glu Lys Gly Asp Val Gly Ser 2500 2505 2510 Ala Gly Leu Lys Gly Asp Lys Gly Asp Ser Ala Val Ile Leu Gly Pro 2515 2520 2525 Pro Gly Pro Arg Gly Ala Lys Gly Asp Met Gly Glu Arg Gly Pro Arg 2530 2535 2540 Gly Leu Asp Gly Asp Lys Gly Pro Arg Gly Asp Asn Gly Asp Pro Gly 2545 2550 2555 2560 Asp Lys Gly Ser Lys Gly Glu Pro Gly Asp Lys Gly Ser Ala Gly Leu 2565 2570 2575 Pro Gly Leu Arg Gly Leu Leu Gly Pro Gln Gly Gln Pro Gly Ala Ala 2580 2585 2590 Gly Ile Pro Gly Asp Pro Gly Ser Pro Gly Lys Asp Gly Val Pro Gly 2595 2600 2605 Ile Arg Gly Glu Lys Gly Asp Val Gly Phe Met Gly Pro Arg Gly Leu 2610 2615 2620 Lys Gly Glu Arg Gly Val Lys Gly Ala Cys Gly Leu Asp Gly Glu Lys 2625 2630 2635 2640 Gly Asp Lys Gly Glu Ala Gly Pro Pro Gly Arg Pro Gly Leu Ala Gly 2645 2650 2655 His Lys Gly Glu Met Gly Glu Pro Gly Val Pro Gly Gln Ser Gly Ala 2660 2665 2670 Pro Gly Lys Glu Gly Leu Ile Gly Pro Lys Gly Asp Arg Gly Phe Asp 2675 2680 2685 Gly Gln Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Glu Arg Gly 2690 2695 2700 Thr Pro Gly Ile Gly Gly Phe Pro Gly Pro Ser Gly Asn Asp Gly Ser 2705 2710 2715 2720 Ala Gly Pro Pro Gly Pro Pro Gly Ser Val Gly Pro Arg Gly Pro Glu 2725 2730 2735 Gly Leu Gln Gly Gln Lys Gly Glu Arg Gly Pro Pro Gly Glu Arg Val 2740 2745 2750 Val Gly Ala Pro Gly Val Pro Gly Ala Pro Gly Glu Arg Gly Glu Gln 2755 2760 2765 Gly Arg Pro Gly Pro Ala Gly Pro Arg Gly Glu Lys Gly Glu Ala Ala 2770 2775 2780 Leu Thr Glu Asp Asp Ile Arg Gly Phe Val Arg Gln Glu Met Ser Gln 2785 2790 2795 2800 His Cys Ala Cys Gln Gly Gln Phe Ile Ala Ser Gly Ser Arg Pro Leu 2805 2810 2815 Pro Ser Tyr Ala Ala Asp Thr Ala Gly Ser Gln Leu His Ala Val Pro 2820 2825 2830 Val Leu Arg Val Ser His Ala Glu Glu Glu Glu Arg Val Pro Pro Glu 2835 2840 2845 Asp Asp Glu Tyr Ser Glu Tyr Ser Glu Tyr Ser Val Glu Glu Tyr Gln 2850 2855 2860 Asp Pro Glu Ala Pro Trp Asp Ser Asp Asp Pro Cys Ser Leu Pro Leu 2865 2870 2875 2880 Asp Glu Gly Ser Cys Thr Ala Tyr Thr Leu Arg Trp Tyr His Arg Ala 2885 2890 2895 Val Thr Gly Ser Thr Glu Ala Cys His Pro Phe Val Tyr Gly Gly Cys 2900 2905 2910 Gly Gly Asn Ala Asn Arg Phe Gly Thr Arg Glu Ala Cys Glu Arg Arg 2915 2920 2925 Cys Pro Pro Arg Val Val Gln Ser Gln Gly Thr Gly Thr Ala Gln Asp 2930 2935 2940 <210> 27 <211> 119 <212> PRT <213> Homo sapiens <400> 27 Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 1 5 10 15 Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 20 25 30 Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 35 40 45 Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 50 55 60 Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 65 70 75 80 Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 85 90 95 Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn 100 105 110 Asp Lys Arg Ser Phe Cys His 115 <210> 28 <211> 1205 <212> PRT <213> Homo sapiens <400> 28 Met Val Lys Cys Tyr His Lys Lys Tyr Arg Ser Ala Thr Arg Asp Val 1 5 10 15 Ile Phe Arg Leu Gln Phe His Thr Gly Ala Val Gln Gly Tyr Gly Leu 20 25 30 Val Phe Gly Lys Glu Asp Leu Asp Asn Ala Ser Lys Asp Asp Arg Phe 35 40 45 Pro Asp Tyr Gly Lys Val Glu Leu Val Phe Ser Ala Thr Pro Glu Lys 50 55 60 Ile Gln Gly Ser Glu His Leu Tyr Asn Asp His Gly Val Ile Val Asp 65 70 75 80 Tyr Asn Thr Thr Asp Pro Leu Ile Arg Trp Asp Ser Tyr Glu Asn Leu 85 90 95 Ser Ala Asp Gly Glu Val Leu His Thr Gln Gly Pro Val Asp Gly Ser 100 105 110 Leu Tyr Ala Lys Val Arg Lys Lys Ser Ser Ser Asp Pro Gly Ile Pro 115 120 125 Gly Gly Pro Gln Ala Ile Pro Ala Thr Asn Ser Pro Asp His Ser Asp 130 135 140 His Thr Leu Ser Val Ser Ser Asp Ser Gly His Ser Thr Ala Ser Ala 145 150 155 160 Arg Thr Asp Lys Thr Glu Glu Arg Leu Ala Pro Gly Thr Arg Arg Gly 165 170 175 Leu Ser Ala Gln Glu Lys Ala Glu Leu Asp Gln Leu Leu Ser Gly Phe 180 185 190 Gly Leu Glu Asp Pro Gly Ser Ser Leu Lys Glu Met Thr Asp Ala Arg 195 200 205 Ser Lys Tyr Ser Gly Thr Arg His Val Val Pro Ala Gln Val His Val 210 215 220 Asn Gly Asp Ala Ala Leu Lys Asp Arg Glu Thr Asp Ile Leu Asp Asp 225 230 235 240 Glu Met Pro His His Asp Leu His Ser Val Asp Ser Leu Gly Thr Leu 245 250 255 Ser Ser Ser Glu Gly Pro Gln Ser Ala His Leu Gly Pro Phe Thr Cys 260 265 270 His Lys Ser Ser Gln Asn Ser Leu Leu Ser Asp Gly Phe Gly Ser Asn 275 280 285 Val Gly Glu Asp Pro Gln Gly Thr Leu Val Pro Asp Leu Gly Leu Gly 290 295 300 Met Asp Gly Pro Tyr Glu Arg Glu Arg Thr Phe Gly Ser Arg Glu Pro 305 310 315 320 Lys Gln Pro Gln Pro Leu Leu Arg Lys Pro Ser Val Ser Ala Gln Met 325 330 335 Gln Ala Tyr Gly Gln Ser Ser Tyr Ser Thr Gln Thr Trp Val Arg Gln 340 345 350 Gln Gln Met Val Val Ala His Gln Tyr Ser Phe Ala Pro Asp Gly Glu 355 360 365 Ala Arg Leu Val Ser Arg Cys Pro Ala Asp Asn Pro Gly Leu Val Gln 370 375 380 Ala Gln Pro Arg Val Pro Leu Thr Pro Thr Arg Gly Thr Ser Ser Arg 385 390 395 400 Val Ala Val Gln Arg Gly Val Gly Ser Gly Pro His Pro Pro Asp Thr 405 410 415 Gln Gln Pro Ser Pro Ser Lys Ala Phe Lys Pro Arg Phe Pro Gly Asp 420 425 430 Gln Val Val Asn Gly Ala Gly Pro Glu Leu Ser Thr Gly Pro Ser Pro 435 440 445 Gly Ser Pro Thr Leu Asp Ile Asp Gln Ser Ile Glu Gln Leu Asn Arg 450 455 460 Leu Ile Leu Glu Leu Asp Pro Thr Phe Glu Pro Ile Pro Thr His Met 465 470 475 480 Asn Ala Leu Gly Ser Gln Ala Asn Gly Ser Val Ser Pro Asp Ser Val 485 490 495 Gly Gly Gly Leu Arg Ala Ser Ser Arg Leu Pro Asp Thr Gly Glu Gly 500 505 510 Pro Ser Arg Ala Thr Gly Arg Gln Gly Ser Ser Ala Glu Gln Pro Leu 515 520 525 Gly Gly Arg Leu Arg Lys Leu Ser Leu Gly Gln Tyr Asp Asn Asp Ala 530 535 540 Gly Gly Gln Leu Pro Phe Ser Lys Cys Ala Trp Gly Lys Ala Gly Val 545 550 555 560 Asp Tyr Ala Pro Asn Leu Pro Pro Phe Pro Ser Pro Ala Asp Val Lys 565 570 575 Glu Thr Met Thr Pro Gly Tyr Pro Gln Asp Leu Asp Ile Ile Asp Gly 580 585 590 Arg Ile Leu Ser Ser Lys Glu Ser Met Cys Ser Thr Pro Ala Phe Pro 595 600 605 Val Ser Pro Glu Thr Pro Tyr Val Lys Thr Ala Leu Arg His Pro Pro 610 615 620 Phe Ser Pro Pro Glu Pro Pro Leu Ser Ser Pro Ala Ser Gln His Lys 625 630 635 640 Gly Gly Arg Glu Pro Arg Ser Cys Pro Glu Thr Leu Thr His Ala Val 645 650 655 Gly Met Ser Glu Ser Pro Ile Gly Pro Lys Ser Thr Met Leu Arg Ala 660 665 670 Asp Ala Ser Ser Thr Pro Ser Phe Gln Gln Ala Phe Ala Ser Ser Cys 675 680 685 Thr Ile Ser Ser Asn Gly Pro Gly Gln Arg Arg Glu Ser Ser Ser Ser 690 695 700 Ala Glu Arg Gln Trp Val Glu Ser Ser Pro Lys Pro Met Val Ser Leu 705 710 715 720 Leu Gly Ser Gly Arg Pro Thr Gly Ser Pro Leu Ser Ala Glu Phe Ser 725 730 735 Gly Thr Arg Lys Asp Ser Pro Val Leu Ser Cys Phe Pro Pro Ser Glu 740 745 750 Leu Gln Ala Pro Phe His Ser His Glu Leu Ser Leu Ala Glu Pro Pro 755 760 765 Asp Ser Leu Ala Pro Pro Ser Ser Gln Ala Phe Leu Gly Phe Gly Thr 770 775 780 Ala Pro Val Gly Ser Gly Leu Pro Pro Glu Glu Asp Leu Gly Ala Leu 785 790 795 800 Leu Ala Asn Ser His Gly Ala Ser Pro Thr Pro Ser Ile Pro Leu Thr 805 810 815 Ala Thr Gly Ala Ala Asp Asn Gly Phe Leu Ser His Asn Phe Leu Thr 820 825 830 Val Ala Pro Gly His Ser Ser His His Ser Pro Gly Leu Gln Gly Gln 835 840 845 Gly Val Thr Leu Pro Gly Gln Pro Pro Leu Pro Glu Lys Lys Arg Ala 850 855 860 Ser Glu Gly Asp Arg Ser Leu Gly Ser Val Ser Pro Ser Ser Ser Gly 865 870 875 880 Phe Ser Ser Pro His Ser Gly Ser Thr Ile Ser Ile Pro Phe Pro Asn 885 890 895 Val Leu Pro Asp Phe Ser Lys Ala Ser Glu Ala Ala Ser Pro Leu Pro 900 905 910 Asp Ser Pro Gly Asp Lys Leu Val Ile Val Lys Phe Val Gln Asp Thr 915 920 925 Ser Lys Phe Trp Tyr Lys Ala Asp Ile Ser Arg Glu Gln Ala Ile Ala 930 935 940 Met Leu Lys Asp Lys Glu Pro Gly Ser Phe Ile Val Arg Asp Ser His 945 950 955 960 Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ala Thr Pro Pro 965 970 975 Pro Ser Val Leu Gln Leu Asn Lys Lys Ala Gly Asp Leu Ala Asn Glu 980 985 990 Leu Val Arg His Phe Leu Ile Glu Cys Thr Pro Lys Gly Val Arg Leu 995 1000 1005 Lys Gly Cys Ser Asn Glu Pro Tyr Phe Gly Ser Leu Thr Ala Leu Val 1010 1015 1020 Cys Gln His Ser Ile Thr Pro Leu Ala Leu Pro Cys Lys Leu Leu Ile 1025 1030 1035 1040 Pro Glu Arg Asp Pro Leu Glu Glu Ile Ala Glu Ser Ser Pro Gln Thr 1045 1050 1055 Ala Ala Asn Ser Ala Ala Glu Leu Leu Lys Gln Gly Ala Ala Cys Asn 1060 1065 1070 Val Trp Tyr Leu Asn Ser Val Glu Met Glu Ser Leu Thr Gly His Gln 1075 1080 1085 Ala Ile Gln Lys Ala Leu Ser Ile Thr Leu Val Gln Glu Pro Pro Pro 1090 1095 1100 Val Ser Thr Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu 1105 1110 1115 1120 Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val Asn 1125 1130 1135 Ser Val Ile Phe Cys Ala Leu Asp Pro Gln Asp Arg Lys Trp Ile Lys 1140 1145 1150 Asp Gly Pro Ser Ser Lys Val Phe Gly Phe Val Ala Arg Lys Gln Gly 1155 1160 1165 Ser Ala Thr Asp Asn Val Cys His Leu Phe Ala Glu His Asp Pro Glu 1170 1175 1180 Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met Ile Gly 1185 1190 1195 1200 Ser Pro Lys Lys Val 1205 <210> 29 <211> 620 <212> PRT <213> Homo sapiens <400> 29 Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 1 5 10 15 Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 20 25 30 Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 35 40 45 Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 50 55 60 Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 65 70 75 80 Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 85 90 95 Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 100 105 110 Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 115 120 125 Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 130 135 140 Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 145 150 155 160 Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 165 170 175 Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro 180 185 190 Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 195 200 205 Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 210 215 220 Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 225 230 235 240 Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 245 250 255 Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 260 265 270 Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 275 280 285 Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 290 295 300 Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 305 310 315 320 Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 325 330 335 Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 340 345 350 Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 355 360 365 Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 370 375 380 Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 385 390 395 400 Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 405 410 415 His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 420 425 430 Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 435 440 445 Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 450 455 460 Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 465 470 475 480 Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala 485 490 495 Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 500 505 510 Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 515 520 525 Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 530 535 540 Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr 545 550 555 560 Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala 565 570 575 Ser Thr Tyr Ser Glu Phe Ala Lys Asp Pro Ser Leu Ser Asp Ser Ser 580 585 590 Thr Val Gly Leu Gln Arg Glu Leu Ser Lys Ala Ser Lys Ser Asp Ala 595 600 605 Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser 610 615 620 <210> 30 <211> 90 <212> PRT <213> Homo sapiens <400> 30 Met Arg Asp Pro Val Ser Ser Gln Tyr Ser Ser Phe Leu Phe Trp Arg 1 5 10 15 Met Pro Ile Pro Glu Leu Asp Leu Ser Glu Leu Glu Gly Leu Gly Leu 20 25 30 Ser Asp Thr Ala Thr Tyr Lys Val Lys Asp Ser Ser Val Gly Lys Met 35 40 45 Ile Gly Gln Ala Thr Ala Ala Asp Gln Glu Lys Asn Pro Glu Gly Asp 50 55 60 Gly Leu Leu Glu Tyr Ser Thr Phe Asn Phe Trp Arg Ala Pro Ile Ala 65 70 75 80 Ser Ile His Ser Phe Glu Leu Asp Leu Leu 85 90 <210> 31 <211> 763 <212> PRT <213> Homo sapiens <400> 31 Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 1 5 10 15 Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 20 25 30 Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 35 40 45 Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 50 55 60 Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 65 70 75 80 Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 85 90 95 Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 100 105 110 Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 115 120 125 Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 130 135 140 Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 145 150 155 160 Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 165 170 175 Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 180 185 190 Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 195 200 205 Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 210 215 220 Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 225 230 235 240 Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 245 250 255 Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 260 265 270 Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 275 280 285 Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 290 295 300 Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 305 310 315 320 Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 325 330 335 His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 340 345 350 Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 355 360 365 Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 370 375 380 Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 385 390 395 400 Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 405 410 415 Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 420 425 430 Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 435 440 445 Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 450 455 460 Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 465 470 475 480 Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 485 490 495 Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 500 505 510 Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 515 520 525 Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 530 535 540 Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 545 550 555 560 Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 565 570 575 Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 580 585 590 Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 595 600 605 Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 610 615 620 Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 625 630 635 640 Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 645 650 655 Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 660 665 670 Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 675 680 685 Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 690 695 700 Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 705 710 715 720 Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 725 730 735 Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 740 745 750 Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 755 760 <210> 32 <211> 464 <212> PRT <213> Homo sapiens <400> 32 Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser 1 5 10 15 Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly 20 25 30 Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys 35 40 45 Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg 50 55 60 Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys 65 70 75 80 Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser 85 90 95 Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu 100 105 110 Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu 115 120 125 Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser 130 135 140 Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe 145 150 155 160 Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp 165 170 175 Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu 180 185 190 Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys 195 200 205 Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu 210 215 220 Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu 225 230 235 240 Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr 245 250 255 Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr 260 265 270 Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg 275 280 285 Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile 290 295 300 Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu 305 310 315 320 Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr 325 330 335 Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu 340 345 350 Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu 355 360 365 Asp Arg Gln His Val Gln His Gln Leu Leu Val Ile Leu Lys Glu Leu 370 375 380 Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu 385 390 395 400 His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr 405 410 415 Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala 420 425 430 Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro 435 440 445 Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys 450 455 460 <210> 33 <211> 318 <212> PRT <213> Homo sapiens <400> 33 Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 1 5 10 15 Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 20 25 30 Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 35 40 45 Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 50 55 60 Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 65 70 75 80 Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 85 90 95 Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 100 105 110 Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 115 120 125 Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 130 135 140 Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 145 150 155 160 Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 165 170 175 Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 180 185 190 Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 195 200 205 Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 210 215 220 Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 225 230 235 240 Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 245 250 255 Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 260 265 270 Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 275 280 285 Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 290 295 300 Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 305 310 315 <210> 34 <211> 250 <212> PRT <213> Homo sapiens <400> 34 Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 1 5 10 15 Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 20 25 30 Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 35 40 45 Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 50 55 60 Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 65 70 75 80 Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 85 90 95 Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 100 105 110 Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 115 120 125 Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 130 135 140 Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 145 150 155 160 Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 165 170 175 Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 180 185 190 Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 195 200 205 Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 210 215 220 Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 225 230 235 240 Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 245 250 <210> 35 <211> 152 <212> PRT <213> Homo sapiens <400> 35 Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys 1 5 10 15 Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile 20 25 30 Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly 35 40 45 Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe 50 55 60 Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp 65 70 75 80 Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu 85 90 95 Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile 100 105 110 Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp 115 120 125 Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro 130 135 140 Thr Asp Pro Ala Asp Gly Pro Val 145 150 <210> 36 <211> 497 <212> PRT <213> Homo sapiens <400> 36 Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 1 5 10 15 Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 20 25 30 Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 35 40 45 Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 50 55 60 Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 65 70 75 80 Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 85 90 95 Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 100 105 110 Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 115 120 125 Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 130 135 140 Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 145 150 155 160 His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 165 170 175 Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 180 185 190 Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 195 200 205 Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 210 215 220 Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 225 230 235 240 Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 245 250 255 Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 260 265 270 Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 275 280 285 Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 290 295 300 Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 305 310 315 320 Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 325 330 335 His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 340 345 350 Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 355 360 365 Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 370 375 380 Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 385 390 395 400 Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 405 410 415 Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 420 425 430 Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 435 440 445 Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 450 455 460 Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 465 470 475 480 Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 485 490 495 Gln <210> 37 <211> 334 <212> PRT <213> Homo sapiens <400> 37 Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 1 5 10 15 Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 20 25 30 Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln 35 40 45 Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 50 55 60 Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 65 70 75 80 Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 85 90 95 Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 100 105 110 Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 115 120 125 Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 130 135 140 Ala Gly Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 145 150 155 160 Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr 165 170 175 Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 180 185 190 Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 195 200 205 Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn 210 215 220 Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 225 230 235 240 Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 245 250 255 Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 260 265 270 Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 275 280 285 Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly 290 295 300 Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 305 310 315 320 Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser 325 330 <210> 38 <211> 168 <212> PRT <213> Homo sapiens <400> 38 Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 1 5 10 15 Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 20 25 30 Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 35 40 45 Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 50 55 60 Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 65 70 75 80 Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 85 90 95 Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 100 105 110 Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 115 120 125 Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 130 135 140 Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 145 150 155 160 Lys Lys Gln Glu Lys Met Leu Asp 165 <210> 39 <211> 316 <212> PRT <213> Homo sapiens <400> 39 Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 1 5 10 15 Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val 20 25 30 Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 35 40 45 Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 50 55 60 Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 65 70 75 80 Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr 85 90 95 Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 100 105 110 Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 115 120 125 Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala 130 135 140 Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 145 150 155 160 Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 165 170 175 Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr 180 185 190 Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr 195 200 205 Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 210 215 220 Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 225 230 235 240 His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg 245 250 255 Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu 260 265 270 Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr 275 280 285 Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys 290 295 300 Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 305 310 315 <210> 40 <211> 384 <212> PRT <213> Homo sapiens <400> 40 Met Ala Ile Ala Tyr Leu Gly Ser Ser Cys Pro Ser Gln Pro Pro Ser 1 5 10 15 Ser Leu Ala Leu Ser Leu Ser Pro Thr Pro Ser Asp Phe Glu Gln Glu 20 25 30 Ser Gly Ile Glu Thr Ala Met Arg Phe Ser Pro Asp Val Ala Leu Ala 35 40 45 Val Ser Thr Thr Pro Ala Val Leu Pro Thr Thr Asn Ile Gln Pro Val 50 55 60 Gly Thr Pro Phe Glu Glu Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro 65 70 75 80 Ala Thr Ser Pro Leu Val Val Thr Glu Val Pro Glu Glu Pro Ser Gln 85 90 95 Arg Ala Thr Thr Val Ser Thr Thr Met Ala Thr Thr Ala Ala Thr Ser 100 105 110 Thr Gly Asp Pro Thr Val Ala Thr Val Pro Ala Thr Val Ala Thr Ala 115 120 125 Thr Pro Ser Thr Pro Ala Ala Pro Pro Phe Thr Ala Thr Thr Ala Val 130 135 140 Ile Arg Thr Thr Gly Val Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr 145 150 155 160 Val Ala Thr Ala Arg Ala Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr 165 170 175 Thr Ala Ala Val Leu Asp Thr Glu Ala Pro Thr Pro Arg Leu Val Ser 180 185 190 Thr Ala Thr Ser Arg Pro Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln 195 200 205 Glu Pro Asp Ile Pro Glu Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala 210 215 220 Pro Gly Pro Thr Glu Val Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu 225 230 235 240 Thr Thr Ile Arg Asp Glu Pro Glu Val Pro Val Ser Gly Gly Pro Ser 245 250 255 Gly Asp Phe Glu Leu Pro Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala 260 265 270 Asn Glu Val Val Ala Val Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro 275 280 285 Pro Gly Thr Leu Pro Lys Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp 290 295 300 Asn Ala Ile Asp Ser Gly Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser 305 310 315 320 Ile Leu Glu Arg Lys Glu Val Leu Val Ala Val Ile Val Gly Gly Val 325 330 335 Val Gly Ala Leu Phe Ala Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg 340 345 350 Met Lys Lys Lys Asp Glu Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln 355 360 365 Ala Ser Val Thr Tyr Gln Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 370 375 380 <210> 41 <211> 211 <212> PRT <213> Homo sapiens <400> 41 Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 1 5 10 15 Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210 <210> 42 <211> 322 <212> PRT <213> Homo sapiens <400> 42 Met Leu Ser Pro Leu Pro Thr Gly Pro Leu Glu Ala Cys Phe Ser Val 1 5 10 15 Gln Ser Arg Thr Ser Ser Pro Met Glu Pro Pro Ile Pro Gln Ser Ala 20 25 30 Pro Leu Thr Pro Asn Ser Val Met Val Gln Pro Leu Leu Asp Ser Arg 35 40 45 Met Ser His Ser Arg Leu Gln His Pro Leu Thr Ile Leu Pro Ile Asp 50 55 60 Gln Val Lys Thr Ser His Val Glu Asn Asp Tyr Ile Asp Asn Pro Ser 65 70 75 80 Leu Ala Leu Thr Thr Gly Pro Lys Arg Thr Arg Gly Gly Ala Pro Glu 85 90 95 Leu Ala Pro Thr Pro Ala Arg Cys Asp Gln Asp Val Thr His His Trp 100 105 110 Ile Ser Phe Ser Gly Arg Pro Ser Ser Val Ser Ser Ser Ser Ser Thr 115 120 125 Ser Ser Asp Gln Arg Leu Leu Asp His Met Ala Pro Pro Pro Val Ala 130 135 140 Asp Gln Ala Ser Pro Arg Ala Val Arg Ile Gln Pro Lys Val Val His 145 150 155 160 Cys Gln Pro Leu Asp Leu Lys Gly Pro Ala Val Pro Pro Glu Leu Asp 165 170 175 Lys His Phe Leu Leu Cys Glu Ala Cys Gly Lys Cys Lys Cys Lys Glu 180 185 190 Cys Ala Ser Pro Arg Thr Leu Pro Ser Cys Trp Val Cys Asn Gln Glu 195 200 205 Cys Leu Cys Ser Ala Gln Thr Leu Val Asn Tyr Gly Thr Cys Met Cys 210 215 220 Leu Val Gln Gly Ile Phe Tyr His Cys Thr Asn Glu Asp Asp Glu Gly 225 230 235 240 Ser Cys Ala Asp His Pro Cys Ser Cys Ser Arg Ser Asn Cys Cys Ala 245 250 255 Arg Trp Ser Phe Met Gly Ala Leu Ser Val Val Leu Pro Cys Leu Leu 260 265 270 Cys Tyr Leu Pro Ala Thr Gly Cys Val Lys Leu Ala Gln Arg Gly Tyr 275 280 285 Asp Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser Val 290 295 300 Ile Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp Lys 305 310 315 320 Pro Phe <210> 43 <211> 623 <212> PRT <213> Homo sapiens <400> 43 Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys 1 5 10 15 Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala 20 25 30 Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met 35 40 45 Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg 50 55 60 Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro 65 70 75 80 Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu 85 90 95 Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val 100 105 110 Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly 115 120 125 Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys 130 135 140 Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu 145 150 155 160 Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp 165 170 175 Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro 180 185 190 Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala 195 200 205 Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu 210 215 220 Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala 225 230 235 240 Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser 245 250 255 Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln 260 265 270 Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro 275 280 285 Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro 290 295 300 Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala 305 310 315 320 Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile 325 330 335 Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys 340 345 350 Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn 355 360 365 Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro 370 375 380 Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile 385 390 395 400 Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His 405 410 415 Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu 420 425 430 Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro 435 440 445 Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr 450 455 460 Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile 465 470 475 480 Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu 485 490 495 Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu 500 505 510 His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn 515 520 525 Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu 530 535 540 Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu 545 550 555 560 Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val 565 570 575 Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val 580 585 590 Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp 595 600 605 Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala 610 615 620 <210> 44 <211> 178 <212> PRT <213> Homo sapiens <400> 44 Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 1 5 10 15 Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 20 25 30 Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 35 40 45 Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 50 55 60 Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 65 70 75 80 Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 85 90 95 Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 100 105 110 Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 115 120 125 Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 130 135 140 Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 145 150 155 160 Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 165 170 175 Cys Arg <210> 45 <211> 228 <212> PRT <213> Homo sapiens <400> 45 Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 1 5 10 15 Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 20 25 30 Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 35 40 45 Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 50 55 60 Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 65 70 75 80 Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 85 90 95 Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 100 105 110 His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 115 120 125 Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 130 135 140 Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 145 150 155 160 Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 165 170 175 Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 180 185 190 Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 195 200 205 Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 210 215 220 Arg Glu Met Val 225 <210> 46 <211> 239 <212> PRT <213> Homo sapiens <400> 46 Met Ala Lys Pro Cys Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln 1 5 10 15 Val Glu Val Phe Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu 20 25 30 Tyr Arg Phe Leu Pro Gln Lys Ile Ile Tyr Leu Asn Gln Leu Leu Gln 35 40 45 Glu Asp Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu 50 55 60 Asp Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr 65 70 75 80 Asp Lys Gln Glu Lys Lys Glu Val His Lys Cys Gly Phe Leu Pro Gly 85 90 95 Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val Trp 100 105 110 Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile Gln His Leu 115 120 125 Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly Val Ala Ile Gln Glu 130 135 140 Lys Val Leu Glu Arg Val Asn Ala Val Lys Thr Lys Val Glu Ala Phe 145 150 155 160 Gln Thr Thr Ile Ser Lys Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala 165 170 175 Lys Ala Ser Lys Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His 180 185 190 Glu Arg Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp 195 200 205 Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn Leu 210 215 220 Glu Lys Ile Val Asn Pro Lys Gly Glu Glu Lys Pro Ser Met Tyr 225 230 235 <210> 47 <211> 672 <212> PRT <213> Homo sapiens <400> 47 Met Ala Asp Gly Ser Leu Thr Gly Gly Gly Leu Glu Ala Ala Ala Met 1 5 10 15 Ala Pro Glu Arg Thr Gly Trp Ala Val Glu Gln Glu Leu Ala Ser Leu 20 25 30 Glu Lys Gly Leu Phe Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr 35 40 45 Arg Asp Lys Pro Gly Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys 50 55 60 Thr Phe Phe Pro Glu Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu 65 70 75 80 Arg Phe Arg Ala Tyr Gln Asp Tyr Ile Leu Ala Asp Cys Lys Ala Ser 85 90 95 Glu Val Gln Glu Phe Thr Ala Glu Phe Leu Glu Lys Val Leu Glu Pro 100 105 110 Ser Gly Trp Arg Ala Val Trp His Thr Asn Val Phe Lys Val Leu Val 115 120 125 Glu Ile Thr Asp Val Asp Phe Ala Ala Leu Lys Ala Val Val Arg Leu 130 135 140 Ala Glu Pro Tyr Leu Cys Asp Ser Gln Val Ser Thr Phe Thr Met Glu 145 150 155 160 Cys Met Lys Glu Leu Leu Asp Leu Lys Glu His Arg Leu Pro Leu Gln 165 170 175 Glu Leu Trp Val Val Phe Asp Asp Ser Gly Val Phe Asp Gln Thr Ala 180 185 190 Leu Ala Ile Glu His Val Arg Phe Phe Tyr Gln Asn Ile Trp Arg Ser 195 200 205 Trp Asp Glu Glu Glu Glu Asp Glu Tyr Asp Tyr Phe Val Arg Cys Val 210 215 220 Glu Pro Arg Leu Arg Leu His Tyr Asp Ile Leu Glu Asp Arg Val Pro 225 230 235 240 Ser Gly Leu Ile Val Asp Tyr His Asn Leu Leu Ser Gln Cys Glu Glu 245 250 255 Ser Tyr Arg Lys Phe Leu Asn Leu Arg Ser Ser Leu Ser Asn Cys Asn 260 265 270 Ser Asp Ser Glu Gln Glu Asn Ile Ser Met Val Glu Gly Leu Lys Leu 275 280 285 Tyr Ser Glu Met Glu Gln Leu Lys Gln Lys Leu Lys Leu Ile Glu Asn 290 295 300 Pro Leu Leu Arg Tyr Val Phe Gly Tyr Gln Lys Asn Ser Asn Ile Gln 305 310 315 320 Ala Lys Gly Val Arg Ser Ser Gly Gln Lys Ile Thr His Val Val Ser 325 330 335 Ser Thr Met Met Ala Gly Leu Leu Arg Ser Leu Leu Thr Asp Arg Leu 340 345 350 Cys Gln Glu Pro Gly Glu Glu Glu Arg Glu Ile Gln Phe His Ser Asp 355 360 365 Pro Leu Ser Ala Ile Asn Ala Cys Phe Glu Gly Asp Thr Val Ile Val 370 375 380 Cys Pro Gly His Tyr Val Val His Gly Thr Phe Ser Ile Ala Asp Ser 385 390 395 400 Ile Glu Leu Glu Gly Tyr Gly Leu Pro Asp Asp Ile Val Ile Glu Lys 405 410 415 Arg Gly Lys Gly Asp Thr Phe Val Asp Cys Thr Gly Ala Asp Ile Lys 420 425 430 Ile Ser Gly Ile Lys Phe Val Gln His Asp Ala Val Glu Gly Ile Leu 435 440 445 Ile Val His Arg Gly Lys Thr Thr Leu Glu Asn Cys Val Leu Gln Cys 450 455 460 Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala Glu Phe Leu Met Lys 465 470 475 480 Asn Ser Asp Leu Tyr Gly Ala Lys Gly Ala Gly Ile Glu Ile Tyr Pro 485 490 495 Gly Ser Gln Cys Thr Leu Ser Asp Asn Gly Ile His His Cys Lys Glu 500 505 510 Gly Ile Leu Ile Lys Asp Phe Leu Asp Glu His Tyr Asp Ile Pro Lys 515 520 525 Ile Ser Met Val Asn Asn Ile Ile His Asn Asn Glu Gly Tyr Gly Val 530 535 540 Val Leu Val Lys Pro Thr Ile Phe Ser Asp Leu Gln Glu Ser Ala Glu 545 550 555 560 Asp Gly Thr Glu Glu Asn Lys Ala Leu Lys Ile Gln Thr Ser Gly Glu 565 570 575 Pro Asp Val Ala Glu Arg Val Asp Leu Glu Glu Leu Ile Glu Cys Ala 580 585 590 Thr Gly Lys Met Glu Leu Cys Ala Arg Thr Asp Pro Ser Glu Gln Val 595 600 605 Glu Gly Asn Cys Glu Ile Val Asn Glu Leu Ile Ala Ala Ser Thr Gln 610 615 620 Lys Gly Gln Ile Lys Lys Lys Arg Leu Ser Glu Leu Gly Ile Thr Gln 625 630 635 640 Ala Asp Asp Asn Leu Met Ser Gln Glu Met Phe Val Gly Ile Val Gly 645 650 655 Asn Gln Phe Lys Trp Asn Gly Lys Gly Ser Phe Gly Thr Phe Leu Phe 660 665 670 <210> 48 <211> 963 <212> PRT <213> Homo sapiens <400> 48 Met Ala Ala Gln Arg Ile Arg Ala Ala Asn Ser Asn Gly Leu Pro Arg 1 5 10 15 Cys Lys Ser Glu Gly Thr Leu Ile Asp Leu Ser Glu Gly Phe Ser Glu 20 25 30 Thr Ser Phe Asn Asp Ile Lys Val Pro Ser Pro Ser Ala Leu Leu Val 35 40 45 Asp Asn Pro Thr Pro Phe Gly Asn Ala Lys Glu Val Ile Ala Ile Lys 50 55 60 Asp Tyr Cys Pro Thr Asn Phe Thr Thr Leu Lys Phe Ser Lys Gly Asp 65 70 75 80 His Leu Tyr Val Leu Asp Thr Ser Gly Gly Glu Trp Trp Tyr Ala His 85 90 95 Asn Thr Thr Glu Met Gly Tyr Ile Pro Ser Ser Tyr Val Gln Pro Leu 100 105 110 Asn Tyr Arg Asn Ser Thr Leu Ser Asp Ser Gly Met Ile Asp Asn Leu 115 120 125 Pro Asp Ser Pro Asp Glu Val Ala Lys Glu Leu Glu Leu Leu Gly Gly 130 135 140 Trp Thr Asp Asp Lys Lys Val Pro Gly Arg Met Tyr Ser Asn Asn Pro 145 150 155 160 Phe Trp Asn Gly Val Gln Thr Asn Pro Phe Leu Asn Gly Asn Val Pro 165 170 175 Val Met Pro Ser Leu Asp Glu Leu Asn Pro Lys Ser Thr Val Asp Leu 180 185 190 Leu Leu Phe Asp Ala Gly Thr Ser Ser Phe Thr Glu Ser Ser Ser Ala 195 200 205 Thr Thr Asn Ser Thr Gly Asn Ile Phe Asp Glu Leu Pro Val Thr Asn 210 215 220 Gly Leu His Ala Glu Pro Pro Val Arg Arg Asp Asn Pro Phe Phe Arg 225 230 235 240 Ser Lys Arg Ser Tyr Ser Leu Ser Glu Leu Ser Val Leu Gln Ala Lys 245 250 255 Ser Asp Ala Pro Thr Ser Ser Ser Phe Phe Thr Gly Leu Lys Ser Pro 260 265 270 Ala Pro Glu Gln Phe Gln Ser Arg Glu Asp Phe Arg Thr Ala Trp Leu 275 280 285 Asn His Arg Lys Leu Ala Arg Ser Cys His Asp Leu Asp Leu Leu Gly 290 295 300 Gln Ser Pro Gly Trp Gly Gln Thr Gln Ala Val Glu Thr Asn Ile Val 305 310 315 320 Cys Lys Leu Asp Ser Ser Gly Gly Ala Val Gln Leu Pro Asp Thr Ser 325 330 335 Ile Ser Ile His Val Pro Glu Gly His Val Ala Pro Gly Glu Thr Gln 340 345 350 Gln Ile Ser Met Lys Ala Leu Leu Asp Pro Pro Leu Glu Leu Asn Ser 355 360 365 Asp Arg Ser Cys Ser Ile Ser Pro Val Leu Glu Val Lys Leu Ser Asn 370 375 380 Leu Glu Val Lys Thr Ser Ile Ile Leu Glu Met Lys Val Ser Ala Glu 385 390 395 400 Ile Lys Asn Asp Leu Phe Ser Lys Ser Thr Val Gly Leu Gln Cys Leu 405 410 415 Arg Ser Asp Ser Lys Glu Gly Pro Tyr Val Ser Val Pro Leu Asn Cys 420 425 430 Ser Cys Gly Asp Thr Val Gln Ala Gln Leu His Asn Leu Glu Pro Cys 435 440 445 Met Tyr Val Ala Val Val Ala His Gly Pro Ser Ile Leu Tyr Pro Ser 450 455 460 Thr Val Trp Asp Phe Ile Asn Lys Lys Val Thr Val Gly Leu Tyr Gly 465 470 475 480 Pro Lys His Ile His Pro Ser Phe Lys Thr Val Val Thr Ile Phe Gly 485 490 495 His Asp Cys Ala Pro Lys Thr Leu Leu Val Ser Glu Val Thr Arg Gln 500 505 510 Ala Pro Asn Pro Ala Pro Val Ala Leu Gln Leu Trp Gly Lys His Gln 515 520 525 Phe Val Leu Ser Arg Pro Gln Asp Leu Lys Val Cys Met Phe Ser Asn 530 535 540 Met Thr Asn Tyr Glu Val Lys Ala Ser Glu Gln Ala Lys Val Val Arg 545 550 555 560 Gly Phe Gln Leu Lys Leu Gly Lys Val Ser Arg Leu Ile Phe Pro Ile 565 570 575 Thr Ser Gln Asn Pro Asn Glu Leu Ser Asp Phe Thr Leu Arg Val Gln 580 585 590 Val Lys Asp Asp Gln Glu Ala Ile Leu Thr Gln Phe Cys Val Gln Thr 595 600 605 Pro Gln Pro Pro Pro Lys Ser Ala Ile Lys Pro Ser Gly Gln Arg Arg 610 615 620 Phe Leu Lys Lys Asn Glu Val Gly Lys Ile Ile Leu Ser Pro Phe Ala 625 630 635 640 Thr Thr Thr Lys Tyr Pro Thr Phe Gln Asp Arg Pro Val Ser Ser Leu 645 650 655 Lys Phe Gly Lys Leu Leu Lys Thr Val Val Arg Gln Asn Lys Asn His 660 665 670 Tyr Leu Leu Glu Tyr Lys Lys Gly Asp Gly Ile Ala Leu Leu Ser Glu 675 680 685 Glu Arg Val Arg Leu Arg Gly Gln Leu Trp Thr Lys Glu Trp Tyr Ile 690 695 700 Gly Tyr Tyr Gln Gly Arg Val Gly Leu Val His Thr Lys Asn Val Leu 705 710 715 720 Val Val Gly Arg Ala Arg Pro Ser Leu Cys Ser Gly Pro Glu Leu Ser 725 730 735 Thr Ser Val Leu Leu Glu Gln Ile Leu Arg Pro Cys Lys Phe Leu Thr 740 745 750 Tyr Ile Tyr Ala Ser Val Arg Thr Leu Leu Met Glu Asn Ile Ser Ser 755 760 765 Trp Arg Ser Phe Ala Asp Ala Leu Gly Tyr Val Asn Leu Pro Leu Thr 770 775 780 Phe Phe Cys Arg Ala Glu Leu Asp Ser Glu Pro Glu Arg Val Ala Ser 785 790 795 800 Val Leu Glu Lys Leu Lys Glu Asp Cys Asn Asn Thr Glu Asn Lys Glu 805 810 815 Arg Lys Ser Phe Gln Lys Glu Leu Val Met Ala Leu Leu Lys Met Asp 820 825 830 Cys Gln Gly Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr 835 840 845 Thr Ala Val Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu 850 855 860 Ala Lys Val Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg 865 870 875 880 Asp Arg Asn Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr 885 890 895 Asp Phe Leu Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp 900 905 910 Val Ile Gln Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile 915 920 925 Thr Lys Arg Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser 930 935 940 Leu Asp Val Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp 945 950 955 960 Phe Val Ile <210> 49 <211> 359 <212> PRT <213> Homo sapiens <400> 49 Thr Asn Lys Leu Glu Gln Pro Arg Gly Gln Glu Phe Trp Ala Asp Leu 1 5 10 15 Asn Ala Met Asn Val Tyr Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg 20 25 30 Leu Ser Thr Pro Pro Ser Ser Asn Val Asn Ser Ile Tyr His Thr Val 35 40 45 Trp Lys Phe Phe Cys Arg Asp His Phe Gly Trp Arg Glu Tyr Pro Glu 50 55 60 Ser Val Ile Arg Leu Ile Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu 65 70 75 80 Val Arg Phe Met Met Trp Asn Asn His Tyr Ile Leu His Asn Ser Phe 85 90 95 Phe Arg Arg Glu Ile Lys Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile 100 105 110 Leu Leu Pro Tyr Leu Gln Thr Leu Gly Gly Val Pro Thr Gln Ala Pro 115 120 125 Pro Pro Leu Glu Ala Thr Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly 130 135 140 Val Thr Ser Ala Asn Phe Tyr Pro Glu Thr Trp Val Tyr Met His Pro 145 150 155 160 Ser Gln Asp Phe Ile Gln Val Pro Val Ser Ala Glu Asp Lys Ser Tyr 165 170 175 Arg Ile Ile Tyr Asn Leu Phe His Lys Thr Val Pro Glu Phe Lys Tyr 180 185 190 Arg Ile Leu Gln Ile Leu Arg Val Gln Asn Gln Phe Leu Trp Glu Lys 195 200 205 Tyr Lys Arg Lys Lys Glu Tyr Met Asn Arg Lys Met Phe Gly Arg Asp 210 215 220 Arg Ile Ile Asn Glu Arg His Leu Phe His Gly Thr Ser Gln Asp Val 225 230 235 240 Val Asp Gly Ile Cys Lys His Asn Phe Asp Pro Arg Val Cys Gly Lys 245 250 255 His Ala Thr Met Phe Gly Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser 260 265 270 Tyr Ser His Asn Phe Ser Lys Lys Ser Ser Lys Gly Val His Phe Met 275 280 285 Phe Leu Ala Lys Val Leu Thr Gly Arg Tyr Thr Met Gly Ser His Gly 290 295 300 Met Arg Arg Pro Pro Pro Val Asn Pro Gly Ser Val Thr Ser Asp Leu 305 310 315 320 Tyr Asp Ser Cys Val Asp Asn Phe Phe Glu Pro Gln Ile Phe Val Ile 325 330 335 Phe Asn Asp Asp Gln Ser Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu 340 345 350 Val Ser Asn Thr Val Ser Ile 355<110> Kyungpook National University Industrial Collaboration Foundation <120> Genes with activity forming hair follicle <160> 49 <170> KopatentIn 1.71 <210> 1 <211> 9272 <212> DNA <213> Homo sapiens <400> 1 gggctggagg ggcgctgggc tcggacctgc caaggccacc gcagggggga gcaagggaca 60 gaggcggggg tcctagctga cggcttttac tgcctaggat gacgctgcgg cttctggtgg 120 ccgcgctctg cgccgggatc ctggcagagg cgccccgagt gcgagcccag cacagggaga 180 gagtgacctg cacgcgcctt tacgccgctg acattgtgtt cttactggat ggctcctcat 240 ccattggccg cagcaatttc cgcgaggtcc gcagctttct cgaagggctg gtgctgcctt 300 tctctggagc agccagtgca cagggtgtgc gctttgccac agtgcagtac agcgatgacc 360 cacggacaga gttcggcctg gatgcacttg gctctggggg tgatgtgatc cgcgccatcc 420 gtgagcttag ctacaagggg ggcaacactc gcacaggggc tgcaattctc catgtggctg 480 accatgtctt cctgccccag ctggcccgac ctggtgtccc caaggtctgc atcctgatca 540 cagacgggaa gtcccaggac ctggtggaca cagctgccca aaggctgaag gggcaggggg 600 tcaagctatt tgctgtgggg atcaagaatg ctgaccctga ggagctgaag cgagttgcct 660 cacagccaac ctccgacttc ttcttcttcg tcaatgactt cagcatcttg aggacactac 720 tgcccctcgt ttcccggaga gtgtgcacga ctgctggtgg cgtgcctgtg acccgacctc 780 cggatgactc gacctctgct ccacgagacc tggtgctgtc tgagccaagc agccaatcct 840 tgagagtaca gtggacagcg gccagtggcc ctgtgactgg ctacaaggtc cagtacactc 900 ctctgacggg gctgggacag ccactgccga gtgagcggca ggaggtgaac gtcccagctg 960 gtgagaccag tgtgcggctg cggggtctcc ggccactgac cgagtaccaa gtgactgtga 1020 ttgccctcta cgccaacagc atcggggagg ctgtgagcgg gacagctcgg accactgccc 1080 tagaagggcc ggaactgacc atccagaata ccacagccca cagcctcctg gtggcctggc 1140 ggagtgtgcc aggtgccact ggctaccgtg tgacatggcg ggtcctcagt ggtgggccca 1200 cacagcagca ggagctgggc cctgggcagg gttcagtgtt gctgcgtgac ttggagcctg 1260 gcacggacta tgaggtgacc gtgagcaccc tatttggccg cagtgtgggg cccgccactt 1320 ccctgatggc tcgcactgac gcttctgttg agcagaccct gcgcccggtc atcctgggcc 1380 ccacatccat cctcctttcc tggaacttgg tgcctgaggc ccgtggctac cggttggaat 1440 ggcggcgtga gactggcttg gagccaccgc agaaggtggt actgccctct gatgtgaccc 1500 gctaccagtt ggatgggctg cagccgggca ctgagtaccg cctcacactc tacactctgc 1560 tggagggcca cgaggtggcc acccctgcaa ccgtggttcc cactggacca gagctgcctg 1620 tgagccctgt aacagacctg caagccaccg agctgcccgg gcagcgggtg cgagtgtcct 1680 ggagcccagt ccctggtgcc acccagtacc gcatcattgt gcgcagcacc cagggggttg 1740 agcggaccct ggtgcttcct gggagtcaga cagcattcga cttggatgac gttcaggctg 1800 ggcttagcta cactgtgcgg gtgtctgctc gagtgggtcc ccgtgagggc agtgccagtg 1860 tcctcactgt ccgccgggag ccggaaactc cacttgctgt tccagggctg cgggttgtgg 1920 tgtcagatgc aacgcgagtg agggtggcct ggggacccgt ccctggagcc agtggatttc 1980 ggattagctg gagcacaggc agtggtccgg agtccagcca gacactgccc ccagactcta 2040 ctgccacaga catcacaggg ctgcagcctg gaaccaccta ccaggtggct gtgtcggtac 2100 tgcgaggcag agaggagggc cctgctgcag tcatcgtggc tcgaacggac ccactgggcc 2160 cagtgaggac ggtccatgtg actcaggcca gcagctcatc tgtcaccatt acctggacca 2220 gggttcctgg cgccacagga tacagggttt cctggcactc agcccacggc ccagagaaat 2280 cccagttggt ttctggggag gccacggtgg ctgagctgga tggactggag ccagatactg 2340 agtatacggt gcatgtgagg gcccatgtgg ctggcgtgga tgggccccct gcctctgtgg 2400 ttgtgaggac tgcccctgag cctgtgggtc gtgtgtcgag gctgcagatc ctcaatgctt 2460 ccagcgacgt tctacggatc acctgggtag gggtcactgg agccacagct tacagactgg 2520 cctggggccg gagtgaaggc ggccccatga ggcaccagat actcccagga aacacagact 2580 ctgcagagat ccggggtctc gaaggtggag tcagctactc agtgcgagtg actgcacttg 2640 tcggggaccg cgagggcaca cctgtctcca ttgttgtcac tacgccgcct gaggctccgc 2700 cagccctggg gacgcttcac gtggtgcagc gcggggagca ctcgctgagg ctgcgctggg 2760 agccggtgcc cagagcgcag ggcttccttc tgcactggca acctgagggt ggccaggaac 2820 agtcccgggt cctggggccc gagctcagca gctatcacct ggacgggctg gagccagcga 2880 cacagtaccg cgtgaggctg agtgtcctag ggccggctgg agaagggccc tctgcagagg 2940 tgactgcgcg cactgagtca cctcgtgttc caagcattga actacgtgtg gtggacacct 3000 cgatcgactc ggtgactttg gcctggactc cagtgtccag ggcatccagc tacatcctat 3060 cctggcggcc actcagaggc cctggccagg aagtgcctgg gtccccgcag acacttccag 3120 ggatctcaag ctcccagcgg gtgacagggc tagagcctgg cgtctcttac atcttctccc 3180 tgacgcctgt cctggatggt gtgcggggtc ctgaggcatc tgtcacacag acgccagtgt 3240 gcccccgtgg cctggcggat gtggtgttcc taccacatgc cactcaagac aatgctcacc 3300 gtgcggaggc tacgaggagg gtcctggagc gtctggtgtt ggcacttggg cctcttgggc 3360 cacaggcagt tcaggttggc ctgctgtctt acagtcatcg gccctcccca ctgttcccac 3420 tgaatggctc ccatgacctt ggcattatct tgcaaaggat ccgtgacatg ccctacatgg 3480 acccaagtgg gaacaacctg ggcacagccg tggtcacagc tcacagatac atgttggcac 3540 cagatgctcc tgggcgccgc cagcacgtac caggggtgat ggttctgcta gtggatgaac 3600 ccttgagagg tgacatattc agccccatcc gtgaggccca ggcttctggg cttaatgtgg 3660 tgatgttggg aatggctgga gcggacccag agcagctgcg tcgcttggcg ccgggtatgg 3720 actctgtcca gaccttcttc gccgtggatg atgggccaag cctggaccag gcagtcagtg 3780 gtctggccac agccctgtgt caggcatcct tcactactca gccccggcca gagccctgcc 3840 cagtgtattg tccaaagggc cagaaggggg aacctggaga gatgggcctg agaggacaag 3900 ttgggcctcc tggcgaccct ggcctcccgg gcaggaccgg tgctcccggc ccccaggggc 3960 cccctggaag tgccactgcc aagggcgaga ggggcttccc tggagcagat gggcgtccag 4020 gcagccctgg ccgcgccggg aatcctggga cccctggagc ccctggccta aagggctctc 4080 cagggttgcc tggccctcgt ggggacccgg gagagcgagg acctcgaggc ccaaaggggg 4140 agccgggggc tcccggacaa gtcatcggag gtgaaggacc tgggcttcct gggcggaaag 4200 gggaccctgg accatcgggc ccccctggac ctcgtggacc actgggggac ccaggacccc 4260 gtggcccccc agggcttcct ggaacagcca tgaagggtga caaaggcgat cgtggggagc 4320 ggggtccccc tggaccaggt gaaggtggca ttgctcctgg ggagcctggg ctgccgggtc 4380 ttcccggaag ccctggaccc caaggccccg ttggcccccc tggaaagaaa ggagaaaaag 4440 gtgactctga ggatggagct ccaggcctcc caggacaacc tgggtctccg ggtgagcagg 4500 gcccacgggg acctcctgga gctattggcc ccaaaggtga ccggggcttt ccagggcccc 4560 tgggtgaggc tggagagaag ggcgaacgtg gacccccagg cccagcggga tcccgggggc 4620 tgccaggggt tgctggacgt cctggagcca agggtcctga agggccacca ggacccactg 4680 gccgccaagg agagaagggg gagcctggtc gccctgggga ccctgcagtg gtgggacctg 4740 ctgttgctgg acccaaagga gaaaagggag atgtggggcc cgctgggccc agaggagcta 4800 ccggagtcca aggggaacgg ggcccacccg gcttggttct tcctggagac cctggcccca 4860 agggagaccc tggagaccgg ggtcccattg gccttactgg cagagcagga cccccaggtg 4920 actcagggcc tcctggagag aagggagacc ctgggcggcc tggcccccca ggacctgttg 4980 gcccccgagg acgagatggt gaagttggag agaaaggtga cgagggtcct ccgggtgacc 5040 cgggtttgcc tggaaaagca ggcgagcgtg gccttcgggg ggcacctgga gttcgggggc 5100 ctgtgggtga aaagggagac cagggagatc ctggagagga tggacgaaat ggcagccctg 5160 gatcatctgg acccaagggt gaccgtgggg agccgggtcc cccaggaccc ccgggacggc 5220 tggtagacac aggacctgga gccagagaga agggagagcc tggggaccgc ggacaagagg 5280 gtcctcgagg gcccaagggt gatcctggcc tccctggagc ccctggggaa aggggcattg 5340 aagggtttcg gggaccccca ggcccacagg gggacccagg tgtccgaggc ccagcaggag 5400 aaaagggtga ccggggtccc cctgggctgg atggccggag cggactggat gggaaaccag 5460 gagccgctgg gccctctggg ccgaatggtg ctgcaggcaa agctggggac ccagggagag 5520 acgggcttcc aggcctccgt ggagaacaag gcctccctgg cccctctggt ccccctggat 5580 taccgggaaa gccaggcgag gatgggaaac ctggcctgaa tggaaaaaac ggagaacctg 5640 gggaccctgg agaagacggg aggaagggag agaaaggaga ttcaggcgcc tctgggagag 5700 aaggtcgtga tggccccaag ggtgagcgtg gagctcctgg tatccttgga ccccaggggc 5760 ctccaggcct cccagggcca gtgggccctc ctggccaggg ttttcctggt gtcccaggag 5820 gcacgggccc caagggtgac cgtggggaga ctggatccaa aggggagcag ggcctccctg 5880 gagagcgtgg cctgcgagga gagcctggaa gtgtgccgaa tgtggatcgg ttgctggaaa 5940 ctgctggcat caaggcatct gccctgcggg agatcgtgga gacctgggat gagagctctg 6000 gtagcttcct gcctgtgccc gaacggcgtc gaggccccaa gggggactca ggcgaacagg 6060 gccccccagg caaggagggc cccatcggct ttcctggaga acgcgggctg aagggcgacc 6120 gtggagaccc tggccctcag gggccacctg gtctggccct tggggagagg ggcccccccg 6180 ggccttccgg ccttgccggg gagcctggaa agcctggtat tcccgggctc ccaggcaggg 6240 ctgggggtgt gggagaggca ggaaggccag gagagagggg agaacgggga gagaaaggag 6300 aacgtggaga acagggcaga gatggccctc ctggactccc tggaacccct gggccccccg 6360 gaccccctgg ccccaaggtg tctgtggatg agccaggtcc tggactctct ggagaacagg 6420 gaccccctgg actcaagggt gctaaggggg agccgggcag caatggtgac caaggtccca 6480 aaggagacag gggtgtgcca ggcatcaaag gagaccgggg agagcctgga ccgaggggtc 6540 aggacggcaa cccgggtcta ccaggagagc gtggtatggc tgggcctgaa gggaagccgg 6600 gtctgcaggg tccaagaggc ccccctggcc cagtgggtgg tcatggagac cctggaccac 6660 ctggtgcccc gggtcttgct ggccctgcag gaccccaagg accttctggc ctgaaggggg 6720 agcctggaga gacaggacct ccaggacggg gcctgactgg acctactgga gctgtgggac 6780 ttcctggacc ccccggccct tcaggccttg tgggtccaca ggggtctcca ggtttgcctg 6840 gacaagtggg ggagacaggg aagccgggag ccccaggtcg agatggtgcc agtggaaaag 6900 atggagacag agggagccct ggtgtgccag ggtcaccagg tctgcctggc cctgtcggac 6960 ctaaaggaga acctggcccc acgggggccc ctggacaggc tgtggtcggg ctccctggag 7020 caaagggaga gaagggagcc cctggaggcc ttgctggaga cctggtgggt gagccgggag 7080 ccaaaggtga ccgaggactg ccagggccgc gaggcgagaa gggtgaagct ggccgtgcag 7140 gggagcccgg agaccctggg gaagatggtc agaaaggggc tccaggaccc aaaggtttca 7200 agggtgaccc aggagtcggg gtcccgggct cccctgggcc tcctggccct ccaggtgtga 7260 agggagatct gggcctccct ggcctgcccg gtgctcctgg tgttgttggg ttcccgggtc 7320 agacaggccc tcgaggagag atgggtcagc caggccctag tggagagcgg ggtctggcag 7380 gccccccagg gagagaagga atcccaggac ccctggggcc acctggacca ccggggtcag 7440 tgggaccacc tggggcctct ggactcaaag gagacaaggg agaccctgga gtagggctgc 7500 ctgggccccg aggcgagcgt ggggagccag gcatccgggg tgaagatggc cgccccggcc 7560 aggagggacc ccgaggactc acggggcccc ctggcagcag gggagagcgt ggggagaagg 7620 gtgatgttgg gagtgcagga ctaaagggtg acaagggaga ctcagctgtg atcctggggc 7680 ctccaggccc acggggtgcc aagggggaca tgggtgaacg agggcctcgg ggcttggatg 7740 gtgacaaagg acctcgggga gacaatgggg accctggtga caagggcagc aagggagagc 7800 ctggtgacaa gggctcagcc gggttgccag gactgcgtgg actcctggga ccccagggtc 7860 aacctggtgc agcagggatc cctggtgacc cgggatcccc aggaaaggat ggagtgcctg 7920 gtatccgagg agaaaaagga gatgttggct tcatgggtcc ccggggcctc aagggtgaac 7980 ggggagtgaa gggagcctgt ggccttgatg gagagaaggg agacaaggga gaagctggtc 8040 ccccaggccg ccccgggctg gcaggacaca aaggagagat gggggagcct ggtgtgccgg 8100 gccagtcggg ggcccctggc aaggagggcc tgatcggtcc caagggtgac cgaggctttg 8160 acgggcagcc aggccccaag ggtgaccagg gcgagaaagg ggagcgggga accccaggaa 8220 ttgggggctt cccaggcccc agtggaaatg atggctctgc tggtccccca gggccacctg 8280 gcagtgttgg tcccagaggc cccgaaggac ttcagggcca gaagggtgag cgaggtcccc 8340 ccggagagag agtggtgggg gctcctgggg tccctggagc tcctggcgag agaggggagc 8400 aggggcggcc agggcctgcc ggtcctcgag gcgagaaggg agaagctgca ctgacggagg 8460 atgacatccg gggctttgtg cgccaagaga tgagtcagca ctgtgcctgc cagggccagt 8520 tcatcgcatc tggatcacga cccctcccta gttatgctgc agacactgcc ggctcccagc 8580 tccatgctgt gcctgtgctc cgcgtctctc atgcagagga ggaagagcgg gtaccccctg 8640 aggatgatga gtactctgaa tactccgagt attctgtgga ggagtaccag gaccctgaag 8700 ctccttggga tagtgatgac ccctgttccc tgccactgga tgagggctcc tgcactgcct 8760 acaccctgcg ctggtaccat cgggctgtga caggcagcac agaggcctgt cacccttttg 8820 tctatggtgg ctgtggaggg aatgccaacc gttttgggac ccgtgaggcc tgcgagcgcc 8880 gctgcccacc ccgggtggtc cagagccagg ggacaggtac tgcccaggac tgaggcccag 8940 ataatgagct gagattcagc atcccctgga ggagtcgggg tctcagcaga accccactgt 9000 ccctcccctt ggtgctagag gcttgtgtgc acgtgagcgt gcgagtgcac gtccgttatt 9060 tcagtgactt ggtcccgtgg gtctagcctt cccccctgtg gacaaacccc cattgtggct 9120 cctgccaccc tggcagatga ctcactgtgg gggggtggct gtgggcagtg agcggatgtg 9180 actggcgtct gacccgcccc ttgacccaag cctgtgatga catggtgctg attctggggg 9240 gcattaaagc tgctgtttta aaaggcaaaa aa 9272 <210> 2 <211> 1203 <212> DNA <213> Homo sapiens <400> 2 gatctggggt gctgccagga aaaagcaaat tctggaagtt aatggttttg agtgattttt 60 aaatccttgc tggcggagag gcccgcctct ccccggtatc agcgcttcct cattctttga 120 atccgcggct ccgcggtctt cggcgtcaga ccagccggag gaagcctgtt tgcaatttaa 180 gcgggctgtg aacgcccagg gccggcgggg gcggggccga ggcgggccat tttgaataaa 240 gaggcgtgcc ttccaggcag gctctataag tgaccgccgc ggcgagcgtg cgcgcgttgc 300 aggtcactgt agcggacttc ttttggtttt ctttctcttt ggggcacctc tggactcact 360 ccccagcatg aaggcgctga gcccggtgcg cggctgctac gaggcggtgt gctgcctgtc 420 ggaacgcagt ctggccatcg cccggggccg agggaagggc ccggcagctg aggagccgct 480 gagcttgctg gacgacatga accactgcta ctcccgcctg cgggaactgg tacccggagt 540 cccgagaggc actcagctta gccaggtgga aatcctacag cgcgtcatcg actacattct 600 cgacctgcag gtagtcctgg ccgagccagc ccctggaccc cctgatggcc cccaccttcc 660 catccagaca gccgagctcg ctccggaact tgtcatctcc aacgacaaaa ggagcttttg 720 ccactgactc ggccgtgtcc tgacacctcc agaacgcagg tgctggcgcc cgttctgcct 780 gggaccccgg gaacctctcc tgccggaagc cggacggcag ggatgggccc caacttcgcc 840 ctgcccactt gacttcacca aatcccttcc tggagactaa acctggtgct caggagcgaa 900 ggactgtgaa cttgtagcct gaagagccag agctagctct ggccaccagc tgggcgacgt 960 caccctgctc ccaccccacc cccaagttct aaggtctttt cagagcgtgg aggtgtggaa 1020 ggagtggctg ctctccaaac tatgccaagg cggcggcaga gctggtcttc tggtctcctt 1080 ggagaaaggt tctgttgccc tgatttatga actctataat agagtatata ggttttgtac 1140 cttttttaca ggaaggtgac tttctgtaac aatgcgatgt atattaaact ttttataaaa 1200 gtt 1203 <210> 3 <211> 6702 <212> DNA <213> Homo sapiens <400> 3 ccccgactag cccgacagtc cccgactagc ccgacagccc cagcaggatc tgcatcgtca 60 tcgagccggc ccagcttctg aagggagatg tcatggtgaa atgctaccac aagaaatacc 120 gctcggccac ccgtgacgtc attttccgcc tgcagtttca cactggggct gtgcagggct 180 acgggctggt gtttgggaag gaggatctgg acaatgccag caaagatgac cgttttcctg 240 actatgggaa ggttgaatta gtcttctctg ccacgcctga gaagattcaa gggtccgaac 300 acttgtacaa cgaccacggt gtgattgtgg actacaacac aacagaccca ctgatacgct 360 gggactcgta cgagaacctc agtgcagatg gagaagtgct acacacgcag ggccctgtcg 420 atggcagcct ttacgcgaag gtgaggaaga aaagctcctc ggatcctggc atcccaggtg 480 gcccccaggc aatcccggcc accaacagcc cagaccacag tgaccacacc ttgtctgtca 540 gcagtgactc cggccactct acagcctctg ccaggacgga taagacggaa gagcgcctgg 600 ccccaggaac caggaggggc ctgagtgccc aggagaaggc agagttggac cagctgctca 660 gtggctttgg cctggaagat cctggaagct ccctcaagga aatgactgat gctcgaagca 720 agtacagtgg gacccgccac gtggtgccag cccaggttca cgtgaatgga gacgctgctc 780 tgaaggatcg ggagacagac attctggatg acgagatgcc ccaccacgac ctgcacagtg 840 tggacagcct tgggaccctg tcctcctcgg aagggcctca gtcggcccac ctgggtccct 900 tcacctgcca caagagcagc cagaactcac tcctatctga cggttttggc agcaacgttg 960 gtgaagatcc gcagggcacc ctcgttccgg acctgggcct tggcatggac ggcccctatg 1020 agcgggagcg gacttttggg agtcgagagc ccaagcagcc ccagcccctg ctgagaaagc 1080 cctcagtgtc cgcccagatg caggcctatg ggcagagcag ctactccaca cagacctggg 1140 tgcgccagca gcagatggtt gtagctcacc agtatagctt cgccccagat ggggaggccc 1200 ggctggtgag ccgctgccct gcagacaatc ctggcctcgt ccaggcccag cccagagtgc 1260 cactcacccc cacccgaggg accagcagta gggtggctgt ccagaggggt gtaggcagtg 1320 ggccacatcc ccctgacaca cagcagccct ctcccagcaa agcgttcaaa cccaggtttc 1380 caggagacca ggttgtgaat ggagccggcc cagagctgag cacaggcccc tccccaggct 1440 cgcccaccct ggacatcgac cagtccatcg agcagctcaa caggctgatc ctggagctgg 1500 atcccacctt cgagcccatc cctacccaca tgaacgccct cggtagccag gccaatggct 1560 ctgtgtctcc agacagcgtg ggaggtgggc tccgggcaag cagcaggctg cctgacacag 1620 gagagggccc cagcagggcc accgggcggc aaggctcctc tgctgaacag cccctgggcg 1680 ggagactcag gaagctgagc ctggggcagt acgacaacga tgctgggggg cagctgccct 1740 tctccaaatg tgcatgggga aaggctggtg tggactatgc cccaaacctg ccgccattcc 1800 cctcaccagc ggacgtcaaa gagacgatga cccctggcta tccccaggac ctcgatatta 1860 tcgatggcag aattttaagt agcaaggagt ccatgtgttc aactccagca tttcctgtgt 1920 ctccagagac accgtatgtg aaaacagcgc tgcgccatcc tccgttcagc ccacctgagc 1980 ccccgctgag cagcccagcc agtcagcaca aaggaggacg tgaaccacga agctgccctg 2040 agacgctcac tcacgctgtg gggatgtcag agagccccat cggacccaaa tccacgatgc 2100 tccgggctga tgcgtcctcg acgccctcct ttcagcaggc ttttgcttct tcctgcacca 2160 tttccagcaa cggccctggg cagaggagag agagctcctc ttctgcagaa cgccagtggg 2220 tggagagcag ccccaagccc atggtttccc tgctggggag cggccggccc accggaagtc 2280 ccctcagcgc tgagttctcc ggtaccagga aggactcccc agtgctgtcc tgcttcccgc 2340 cgtcagagct ccaggctcct ttccacagcc atgagctgtc cctagcagag ccaccggact 2400 ccctggcgcc tcccagcagc caggccttcc tgggcttcgg caccgcccca gtgggaagtg 2460 gccttccgcc cgaggaggac ctgggggcct tgctggccaa ttctcatgga gcgtcaccga 2520 cccccagcat cccgctgaca gcgacagggg ctgccgacaa tggcttcctg tcccacaact 2580 ttctcacggt ggcgcctgga cacagcagcc accacagtcc aggcctgcag ggccagggtg 2640 tgaccctgcc cgggcagcca cccctccctg agaagaagcg ggcctcggag ggggatcgtt 2700 ctttgggctc agtctctccc tcctccagtg gcttctccag cccgcacagg gggagcacca 2760 tcagtatccc cttcccaaat gtccttcccg acttttccaa ggcttcagaa gcggcctcac 2820 ctctgccaga tagtccaggt gataaacttg tgatcgtgaa atttgttcaa gacacttcca 2880 agttctggta caaggcggat atttcaagag aacaagccat cgccatgttg aaggacaagg 2940 agccgggctc attcattgtt cgagacagcc attccttccg aggggcctat ggcctggcca 3000 tgaaggtggc cacgccccca ccttcagtcc tgcagctgaa caagaaagct ggagatttgg 3060 ccaatgaact cgtccggcac tttttgatcg agtgtacccc gaagggagtg cggttgaaag 3120 ggtgctcgaa tgaaccatat ttcgggagcc tgacggcctt ggtgtgccag cattccatca 3180 cgcccttggc cttgccgtgc aagctgctta tcccagagag agatccattg gaggaaatag 3240 cagaaagttc tccccagacg gcagccaatt cagcagctga gctgttgaag cagggggcag 3300 cctgcaacgt gtggtacttg aactctgtgg agatggagtc cctcaccggc caccaggcga 3360 tccagaaggc cctgagcatc accctggtcc aggagcctcc acctgtgtcc acagttgtgc 3420 acttcaaggt gtcagcccag ggcatcaccc tgacagacaa tcagaggaag ctcttcttcc 3480 ggaggcatta ccccgtgaac agtgtgattt tctgtgcctt ggacccacaa gacaggaagt 3540 ggatcaaaga tggcccttcc tcaaaagtct ttggatttgt ggcccggaag cagggcagtg 3600 ccacggataa tgtgtgccac ctgtttgcag agcatgaccc tgagcagcct gccagtgcca 3660 ttgtcaactt cgtatcaaag gtcatgattg gttccccaaa gaaggtctga gaactcccct 3720 ccctccctgg acccaccgat gcctctcgaa gccctggaga cagccgttgg gtgagggtgg 3780 ggcccccact ttttaccaaa ctagtaaacc tgacattcca ggcccatgag gggaaagagg 3840 atcttccagc tctgcaaaaa caagaacaaa caacatcacc gtgaattggc ctttcctgaa 3900 agtgacttat ctgacacatc tctgtagcca catgcttttt gggtagaaga agctgggcat 3960 gggtgcaccc caccccctag ggtccccatg ggaaagggac atgcaaggaa acagcacaga 4020 acacgaggtg gtccccatgt ccctggcaca ctagcattcc gggggatgag gaatccccag 4080 cccttgaggc agaggtgccg agtgactgcc atgcttcgcc cgtccgcatg ggcgcttctg 4140 tccagctgca cccgaggccg ggggtttccc tcacctcggt cttcccaaga tggagatgct 4200 aacgaaactg agaagggggc gtatgtttga cgaaggtttg tgcaagtcag gcccttctgg 4260 aacacagcag ggcctacaac gaggggcctt tgcgatgggc tgtgaggatg ggggtggtgg 4320 gaagaattgg ccacgttaga gaccccatgc caccccacca tggtgagtgc tctgtgcctc 4380 ctgctcacct gtggtgagct gggcgagctg ggcgagctgg gcgagctggg ctggggagag 4440 cctgtgagga ccgagaggag aaatgagaag aaggaacaaa aatattattt ctatgtaatt 4500 tatattttac ttatgccaaa ttatttatga taatttgcca ttgctatact gtaccagtgt 4560 caaatgctgc agcctgccaa gctgtgattt tgtgaggctt gtccctatgt aggatgcacc 4620 gcaggcccct ggccactgaa agagtgtgca gtggactgtg ggtctcccat atgcggtgcc 4680 gcccaaaggt ggctttgcct caagcaacct accctgatgt tttactcatt ggaatgtttt 4740 tccccgattg tggatgactt cttttctgat ggagagagtc caggagggat ggaaaactcc 4800 tggatttaag ctcagcatcc cccacatggg cttttcgatc atcttcaggc ctgaagctgc 4860 acgacctgaa gttcgcctgc atttatcagc cctctttgtg ctgctccttg ccaccttggg 4920 gttcctgctg gggaccatgt gtggttgtgg catgtgtgag cagaagggag gatgaggaaa 4980 aagagaagaa accccggtac tgacaagctg tttttgagtg ccactgtttg ccatcatcta 5040 agccactgaa tcaagtgtat ttcaggctta tttcaacatt ccaatgccct ggttttcctg 5100 cttgaatctg ttcgtggtca aaggtttggg ggaatttgtg accctggaac atccccagag 5160 tgaaagatgg agctgggcca catcagaata aggccttggc cccatcctct cacagcctag 5220 gtgctctgca ggcatgctga ctgtcctgat tgcgatccag cccgaaattc cctcctctgc 5280 tttcaaaagt caaatccccc attcttaggc cacactggtg tcacaagctc ctgtcaggga 5340 gctggggttt gggaatgtgc tttgtgaact ctgctttaaa gtgaggggcc gaggaaaact 5400 tagaaacagg cagagttgga agcagccaaa tcacagtggg tgttgtgtgt gtgtgcgtgt 5460 gtgcatgcgt gcgtgtatgc gtgtgtgaaa gcaggtggac cattccactt tttagctcct 5520 attgatgcac caaaccaagt gcctcatttc tgtgccaaat gtttgccttg gtcgttgtgg 5580 acctccttct ctaacttgcg gtggcatgac tgtcaggagg tgctggcatt ttcagcagat 5640 cctcatgtgt tgaccctgat gtctttagca gaggcctcta gcatctcggt ttttcatcca 5700 ctgcaggaat gtggccacag ggagcagagg tttgtacttt ccccaagagg tcctcatcct 5760 gagacggtct ctacccatgt ttaacccaaa gagtgcaggc caggttcctt atccttctga 5820 tgaaggatga gagagctcat ttagaagtca gagcaaacta gggtctcagt attgagaaac 5880 gcagcctgcc agggaatcac agagacatcg gggtgcccgc gatggccctc atgaagccat 5940 gcctcgacgg cattcaggaa gccctgcaaa cgtgcttttt gaactcattg gccaggtgtg 6000 atttttacac aaggtaaacg tggtcaaggg catcggggaa tttgctccaa gcagatagct 6060 ccctctgagg aaccaaagga agcaagtttc cacgatttct gaagagctgg tataggaagt 6120 ttctttcttc cttttgtgtt acatgtgcat taaacagaac aagctgtgtg tcatcacaga 6180 ttgtactgtg ggctcagaaa ccgtgagaga gcccccaccg tggacaccgg ctctagggcc 6240 acaggaaaag gaacgtttcc aggcattttg tctccagggc tcccgctgga caggcacgta 6300 ctgccctggg gagtaaatgc ggagagttca cgaactgtgc ccaacgcatg ttatagccag 6360 ggtcctacta actactcagt aaaagaacgt attgttgtat tcctccagtg ttaagctata 6420 gccatgttaa aagtcactgt gcatttattc tcagcatcaa ataccttgta acgtcttctc 6480 tgccttgtta gtgcatattt ttacttttct gatactgtaa agaatatatc cagtatgtaa 6540 atgaatgttc tataaatctt ttgtatagtc attttctctg ctccttaaat atcatctcta 6600 ttcagagtat aataaaatta tgaacttggt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 6660 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 6702 <210> 4 <211> 3128 <212> DNA <213> Homo sapiens <400> 4 gcttcgcccc gtggcgcggt ttgaaatttt gcggggctca acggctcgcg gagcggctac 60 gcggagtgac atcgccggtg tttgcgggtg gttgttgctc tcggggccgt gtggagtagg 120 tctggacctg gactcacggc tgcttggagc gtccgccatg aggagaagtg aggtgctggc 180 ggaggagtcc atagtatgtc tgcagaaagc cctaaatcac cttcgggaaa tatgggagct 240 aattgggatt ccagaggacc agcggttaca aagaactgag gtggtaaaga agcatatcaa 300 ggaactcctg gatatgatga ttgctgaaga ggaaagcctg aaggaaagac tcatcaaaag 360 catatccgtc tgtcagaaag agctgaacac tctgtgcagc gagttacatg ttgagccatt 420 tcaggaagaa ggagagacga ccatcttgca actagaaaaa gatttgcgca cccaagtgga 480 attgatgcga aaacagaaaa aggagagaaa acaggaactg aagctacttc aagagcaaga 540 tcaagaactg tgcgaaattc tttgtatgcc ccactatgat attgacagtg cctcagtgcc 600 cagcttagaa gagctgaacc agttcaggca acatgtgaca actttgaggg aaacaaaggc 660 ttctaggcgt gaggagtttg tcagtataaa gagacagatc atactgtgta tggaagaatt 720 agaccacacc ccagacacaa gctttgaaag agatgtggtg tgtgaagacg aagatgcctt 780 ttgtttgtct ttggagaata ttgcaacact acaaaagttg ctacggcagc tggaaatgca 840 gaaatcacaa aatgaagcag tgtgtgaggg gctgcgtact caaatccgag agctctggga 900 caggttgcaa atacctgaag aagaaagaga agctgtggcc accattatgt ctgggtcaaa 960 ggccaaggtc cggaaagcgc tgcaattaga agtggatcgg ttggaagaac tgaaaatgca 1020 aaacatgaag aaagtgattg aggcaattcg agtggagctg gttcagtact gggaccagtg 1080 cttttatagc caggagcaga gacaagcttt tgcccctttc tgtgctgagg actacacaga 1140 aagtctgctc cagctccacg atgctgagat tgtgcggtta aaaaactact atgaagttca 1200 caaggaactc tttgaaggtg tccagaagtg ggaagaaacc tggaggcttt tcttagagtt 1260 tgagagaaaa gcttcagatc caaatcgatt tacaaaccga ggaggaaatc ttctaaaaga 1320 agaaaaacaa cgagccaagc tccagaaaat gctgcccaag ctggaagaag agttgaaggc 1380 acgaattgaa ttgtgggaac aggaacattc aaaggcattt atggtgaatg ggcagaaatt 1440 catggagtat gtggcagaac aatgggagat gcatcgattg gagaaagaga gagccaagca 1500 ggaaagacaa ctgaagaaca aaaaacagac agagacagag atgctgtatg gcagcgctcc 1560 tcgaacacct agcaagcggc gaggactggc tcccaataca ccgggcaaag cacgtaagct 1620 gaacactacc accatgtcca atgctacggc caatagtagc attcggccta tctttggagg 1680 gacagtctac cactcccccg tgtctcgact tcctccttct ggcagcaagc cagtcgctgc 1740 ttccacctgt tcagggaaga aaacaccccg tactggcagg catggagcca acaaggagaa 1800 cctggagctc aacggcagca tcctgagtgg tgggtaccct ggctcggccc ccctccagcg 1860 caacttcagc attaattctg ttgccagcac ctattctgag tttgcgaagg atccgtccct 1920 ctctgacagt tccactgttg ggcttcagcg agaactttca aaggcttcca aatctgatgc 1980 tacttctgga atcctcaatt caaccaacat ccagtcctga gaagccctga tcagtcaacc 2040 agctgtggct tcctgtgcct agactggacc taattatatg ggggtgactt tagtttttct 2100 tcagcttagg cgtgcttgaa accttggcca ggttccatga ccatgggcct aacttaaaga 2160 tgtgaatgag tgttacagtt gaaagcccat cataggttta gtggtcctag gagacttggt 2220 tttgacttat atacatgaaa agtttatggc aagaagtgca aattttagca tatggggcct 2280 gacttctcta ccacataatt ctacttgctg aagcatgatc aaagcttgtt ttatttcacc 2340 actgtaggaa aatgattgac tatgcccatc cctgggggta attttggcat gtatacctgt 2400 aactagtaat taacatcttt tttgtttagg catgttcaat taatgctgta gctatcatag 2460 ctttgctctt acctgaagcc ttgtccccac cacacaggac agccttcctc ctgaagagaa 2520 tgtctttgtg tgtccgaagt tgagatggcc tgccctactg ccaaagaggt gacaggaagg 2580 ctgggagcag ctttgttaaa ttgtgttcag ttctgttaca cagtgcattg ccctttgttg 2640 ggggtatgca tgtatgaaca cacatgcttg tcggaacgct ttctcggcgt ttgtcccttg 2700 gctctcatct cccccattcc tgtgcctact ttgcctgagt tcttctaccc ccgcagttgc 2760 cagccacatt gggagtctgt ttgttccaat gggttgagct gtctttgtcg tggagatctg 2820 gaactttgca catgtcacta ctggggaggt gttcctgctc tagcttccac gatgaggcgc 2880 cctctttacc tatcctctca atcactactc ttcttgaagc actattattt attcttccgc 2940 tgtctgcctg cagcagtact actgtcaaca tagtgtaaat ggttctcaaa agcttaccag 3000 tgtggacttg gtgttagcca cgctgtttac tcatacagta cgtgtcctgt ttttaaaata 3060 tacaattatt cttaaaaata aattaaaatc tgtatactta catttcaaaa agaaaaaaaa 3120 aaaaaaaa 3128 <210> 5 <211> 1653 <212> DNA <213> Homo sapiens <400> 5 agtcagcacg ggggtgctgg aagagatcgg gaataatagc gcagaccaat gagcctaggg 60 agatgctttc atcgtctctc cttccctcaa gtgttctgga acctatcatt tgaattagcc 120 gagtcaggca ggagggggcg gggaatcctt ccgcccttct taggaggggc tgcattgcag 180 ggggagagtg aactgacaga ctcagtcact gaagagggaa aaggagtgag aagacaaagc 240 cgtcaaagcc ccaacagctt tgtatttctc cagcccggcg cagaccccgg agctcccgag 300 gcactccctc catctttgga acacgccagt aattgattga taacaggaag ctatgaggga 360 ccctgtgagt agccagtaca gttcctttct tttctggagg atgcccatcc cagaactgga 420 tctgtcggag ctggaaggcc tgggtctgtc agatacagcc acctacaagg tcaaagacag 480 cagcgttggc aaaatgatcg ggcaagcaac tgcagcagac caggagaaaa accctgaagg 540 tgatggcctc cttgagtaca gcaccttcaa cttctggaga gctcccattg ccagcatcca 600 ctccttcgaa ctggacttgc tctaaggcca agacttctct ctcccatcac cttgccctca 660 ttgtcttccc tctcaagccc cttcctttcc actcctttcc cattttaatc ttgttctctc 720 cctactgtgt tggtggtgct gatgaatctg ccagagttga gttctatgta tttatttatc 780 tatctgtcta ctccatttct ctcaaaagcc ctcaagtcac aaagtaaatg gttcaagcaa 840 tggagtactg ggtcacaggg attcctcctt tcccccccaa atattaactc cagaaactag 900 gcctgactgg ggacacctga gagtagtata gtagtgcaaa atggaagact gatttttgac 960 tctattataa tcagcttcag agattcctta aaccttccta atttcctgct ccagggcagt 1020 aaacacaaat atttcttcaa ggggtgatga aaacctcgga agttttaatt tgaggttatc 1080 tgctacgaaa cagtatttct aaaaggctaa agtgataagt ctcttgcttt tttttgatcc 1140 tgctcttata ttcttttttt tcctcagaga aatcaggagg gtagttagag gtataaaaca 1200 ggaggaaata ttatggaaaa tgaaaatagg gaaaataatt gaatcatttt agaagtagct 1260 aatttctttt ctcaaaagag tgtcccttct tcacacctac tcactttaca actttgctcc 1320 taactgtggg ttgaaaactc tagctaaaga aagttatcaa atcttaacat gcattcctac 1380 tattatgata gtttttaagg tttcaattca atcttctgaa cggcataagt cctattttag 1440 ccttacctcc tgcatttgca atacgtaata ctgatcagtg ggcacagttc ttcagctaca 1500 ttgagaccct gaaatgaaca attatattct gactcgacat cttgtcccca atccttccaa 1560 aaatattgat ggtgatttgt gctaccattt actcgtttat ttaataaaga cattcaatcc 1620 cagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1653 <210> 6 <211> 3527 <212> DNA <213> Homo sapiens <400> 6 actgaaagct ccggtgccag accccacccc cggccccggc ccgggacccc ctcccctccc 60 gggatccccc ggggttccca ccccgcccgc accgccgggg acccggccgg tccggcgcga 120 gcccccgtcc ggggccctgg ctcggccccc aggttggagg agcccggagc ccgccttcgg 180 agctacggcc taacggcggc ggcgactgca gtctggaggg tccacacttg tgattctcaa 240 tggagagtga aaacgcagat tcataatgaa aactagcccc cgtcggccac tgattctcaa 300 aagacggagg ctgccccttc ctgttcaaaa tgccccaagt gaaacatcag aggaggaacc 360 taagagatcc cctgcccaac aggagtctaa tcaagcagag gcctccaagg aagtggcaga 420 gtccaactct tgcaagtttc cagctgggat caagattatt aaccacccca ccatgcccaa 480 cacgcaagta gtggccatcc ccaacaatgc taatattcac agcatcatca cagcactgac 540 tgccaaggga aaagagagtg gcagtagtgg gcccaacaaa ttcatcctca tcagctgtgg 600 gggagcccca actcagcctc caggactccg gcctcaaacc caaaccagct atgatgccaa 660 aaggacagaa gtgaccctgg agaccttggg accaaaacct gcagctaggg atgtgaatct 720 tcctagacca cctggagccc tttgcgagca gaaacgggag acctgtgcag atggtgaggc 780 agcaggctgc actatcaaca atagcctatc caacatccag tggcttcgaa agatgagttc 840 tgatggactg ggctcccgca gcatcaagca agagatggag gaaaaggaga attgtcacct 900 ggagcagcga caggttaagg ttgaggagcc ttcgagacca tcagcgtcct ggcagaactc 960 tgtgtctgag cggccaccct actcttacat ggccatgata caattcgcca tcaacagcac 1020 tgagaggaag cgcatgactt tgaaagacat ctatacgtgg attgaggacc actttcccta 1080 ctttaagcac attgccaagc caggctggaa gaactccatc cgccacaacc tttccctgca 1140 cgacatgttt gtccgggaga cgtctgccaa tggcaaggtc tccttctgga ccattcaccc 1200 cagtgccaac cgctacttga cattggacca ggtgtttaag ccactggacc cagggtctcc 1260 acaattgccc gagcacttgg aatcacagca gaaacgaccg aatccagagc tccgccggaa 1320 catgaccatc aaaaccgaac tccccctggg cgcacggcgg aagatgaagc cactgctacc 1380 acgggtcagc tcatacctgg tacctatcca gttcccggtg aaccagtcac tggtgttgca 1440 gccctcggtg aaggtgccat tgcccctggc ggcttccctc atgagctcag agcttgcccg 1500 ccatagcaag cgagtccgca ttgcccccaa ggtgctgcta gctgaggagg ggatagctcc 1560 tctttcttct gcaggaccag ggaaagagga gaaactcctg tttggagaag ggttttctcc 1620 tttgcttcca gttcagacta tcaaggagga agaaatccag cctggggagg aaatgccaca 1680 cttagcgaga cccatcaaag tggagagccc tcccttggaa gagtggccct ccccggcccc 1740 atctttcaaa gaggaatcat ctcactcctg ggaggattcg tcccaatctc ccaccccaag 1800 acccaagaag tcctacagtg ggcttaggtc cccaacccgg tgtgtctcgg aaatgcttgt 1860 gattcaacac agggagagga gggagaggag ccggtctcgg aggaaacagc atctactgcc 1920 tccctgtgtg gatgagccgg agctgctctt ctcagagggg cccagtactt cccgctgggc 1980 cgcagagctc ccgttcccag cagactcctc tgaccctgcc tcccagctca gctactccca 2040 ggaagtggga ggacctttta agacacccat taaggaaacg ctgcccatct cctccacccc 2100 gagcaaatct gtcctcccca gaacccctga atcctggagg ctcacgcccc cagccaaagt 2160 agggggactg gatttcagcc cagtacaaac ctcccagggt gcctctgacc ccttgcctga 2220 ccccctgggg ctgatggatc tcagcaccac tcccttgcaa agtgctcccc cccttgaatc 2280 accgcaaagg ctcctcagtt cagaaccctt agacctcatc tccgtcccct ttggcaactc 2340 ttctccctca gatatagacg tccccaagcc aggctccccg gagccacagg tttctggcct 2400 tgcagccaat cgttctctga cagaaggcct ggtcctggac acaatgaatg acagcctcag 2460 caagatcctg ctggacatca gctttcctgg cctggacgag gacccactgg gccctgacaa 2520 catcaactgg tcccagttta ttcctgagct acagtagagc cctgcccttg cccctgtgct 2580 caagctgtcc accatcccgg gcactccaag gctcagtgca ccccaagcct ctgagtgagg 2640 acagcaggca gggactgttc tgctcctcat agctccctgc tgcctgatta tgcaaaagta 2700 gcagtcacac cctagccact gctgggacct tgtgttcccc aagagtatct gattcctctg 2760 ctgtccctgc caggagctga agggtgggaa caacaaaggc aatggtgaaa agagattagg 2820 aaccccccag cctgtttcca ttctctgccc agcagtctct taccttccct gatctttgca 2880 gggtggtccg tgtaaatagt ataaattctc caaattatcc tctaattata aatgtaagct 2940 tatttcctta gatcattatc cagagactgc cagaaggtgg gtaggatgac ctggggtttc 3000 aattgacttc tgttccttgc ttttagtttt gatagaaggg aagacctgca gtgcacggtt 3060 tcttccaggc tgaggtacct ggatcttggg ttcttcactg cagggaccca gacaagtgga 3120 tctgcttgcc agagtccttt ttgcccctcc ctgccacctc cccgtgtttc caagtcagct 3180 ttcctgcaag aagaaatcct ggttaaaaaa gtcttttgta ttgggtcagg agttgaattt 3240 ggggtgggag gatggatgca actgaagcag agtgtgggtg cccagatgtg cgctattaga 3300 tgtttctctg ataatgtccc caatcatacc agggagactg gcattgacga gaactcaggt 3360 ggaggcttga gaaggccgaa agggcccctg acctgcctgg cttccttagc ttgcccctca 3420 gctttgcaaa gagccaccct aggccccagc tgaccgcatg ggtgtgagcc agcttgagaa 3480 cactaactac tcaataaaag cgaaggtgga caaaaaaaaa aaaaaaa 3527 <210> 7 <211> 2635 <212> DNA <213> Homo sapiens <400> 7 ggccgacgcg agcgccgcgc ttcgcttcag ctgctagctg gcccaaggga ggcgaccgcg 60 gagggtggcg aggggcggcc aggacccgca gccccggggc cgggccggtc cggaccgcca 120 gggagggcag gtcagtgggc agatcgcgtc cgcgggattc aatctctgcc cgctctgata 180 acagtccttt tccctggcgc tcacttcgtg cctggcaccc ggctgggcgc ctcaagaccg 240 ttgtctcttc gatcgcttct ttggacttgg cgaccatttc agagatgtct tccagaagta 300 ccaaagattt aattaaaagt aagtggggat cgaagcctag taactccaaa tccgaaacta 360 cattagaaaa attaaaggga gaaattgcac acttaaagac atcagtggat gaaatcacaa 420 gtgggaaagg aaagctgact gataaagaga gacacagact tttggagaaa attcgagtcc 480 ttgaggctga gaaggagaag aatgcttatc aactcacaga gaaggacaaa gaaatacagc 540 gactgagaga ccaactgaag gccagatata gtactaccgc attgcttgaa cagctggaag 600 agacaacgag agaaggagaa aggagggagc aggtgttgaa agccttatct gaagagaaag 660 acgtattgaa acaacagttg tctgctgcaa cctcacgaat tgctgaactt gaaagcaaaa 720 ccaatacact ccgtttatca cagactgtgg ctccaaactg cttcaactca tcaataaata 780 atattcatga aatggaaata cagctgaaag atgctctgga gaaaaatcag cagtggctcg 840 tgtatgatca gcagcgggaa gtctatgtaa aaggactttt agcaaagatc tttgagttgg 900 aaaagaaaac ggaaacagct gctcattcac tcccacagca gacaaaaaag cctgaatcag 960 aaggttatct tcaagaagag aagcagaaat gttacaacga tctcttggca agtgcaaaaa 1020 aagatcttga ggttgaacga caaaccataa ctcagctgag ttttgaactg agtgaatttc 1080 gaagaaaata tgaagaaacc caaaaagaag ttcacaattt aaatcagctg ttgtattcac 1140 aaagaagggc agatgtgcaa catctggaag atgataggca taaaacagag aagatacaaa 1200 aactcaggga agagaatgat attgctaggg gaaaacttga agaagagaag aagagatccg 1260 aagagctctt atctcaggtc cagtttcttt acacatctct gctaaagcag caagaagaac 1320 aaacaagggt agctctgttg gaacaacaga tgcaggcatg tactttagac tttgaaaatg 1380 aaaaactcga ccgtcaacat gtgcagcatc aattgcttgt aattcttaag gagctccgaa 1440 aagcaagaaa tcaaataaca cagttggaat ccttgaaaca gcttcatgag tttgccatca 1500 cagagccatt agtcactttc caaggagaga ctgaaaacag agaaaaagtt gccgcctcac 1560 caaaaagtcc cactgctgca ctcaatgaaa gcctggtgga atgtcccaag tgcaatatac 1620 agtatccagc cactgagcat cgcgatctgc ttgtccatgt ggaatactgt tcaaagtagc 1680 aaaataagta tttgttttga tattaaaaga ttcaatactg tattttctgt tagcttgtgg 1740 gcattttgaa ttatatattt cacattttgc ataaaactgc ctatctacct ttgacactcc 1800 agcatgctag tgaatcatgt atcttttagg ctgctgtgca tttctcttgg cagtgatacc 1860 tccctgacat ggttcatcat caggctgcaa tgacagaatg tggtgagcag cgtctactga 1920 gactactaac attttgcact gtcaaaatac ttggtgagga aaagatagct caggttattg 1980 ctaatgggtt aatgcaccag caagcaaaat attttatgtt ttgggggttt gaaaaatcaa 2040 agataattaa ccaaggatct taactgtgtt cgcatttttt atccaagcac ttagaaaacc 2100 tacaatccta attttgatgt ccattgttaa gaggtggtga tagatactat tttttttttc 2160 atattgtata gcggttatta gaaaagttgg ggattttctt gatctttatt gctgcttacc 2220 attgaaactt aacccagctg tgttccccaa ctctgttctg cgcacgaaac agtatctgtt 2280 tgaggcataa tcttaagtgg ccacacacaa tgttttctct tatgttatct ggcagtaact 2340 gtaacttgaa ttacattagc acattctgct tagctaaaat tgttaaaata aactttaata 2400 aacccatgta gccctctcat ttgattgaca gtattttagt tatttttggc attcttaaag 2460 ctgggcaatg taatgatcag atctttgttt gtctgaacag gtatttttat acatgctttt 2520 tgtaaaccaa aaacttttaa atttcttcag gttttctaac atgcttacca ctgggctact 2580 gtaaatgaga aaagaataaa attatttaat gttttaaaaa aaaaaaaaaa aaaaa 2635 <210> 8 <211> 1280 <212> DNA <213> Homo sapiens <400> 8 tgccgcagcc cccgcccgcc cgcagagctt ttgaaaggcg gcgggaggcg gcgagcgcca 60 tggccagtcc gggctgcctg ctgtgcgtgc tgggcctgct actctgcggg gcggcgagcc 120 tcgagctgtc tagaccccac ggcgacaccg ccaagaagcc catcatcgga atattaatgc 180 aaaaatgccg taataaagtc atgaaaaact atggaagata ctatattgct gcgtcctatg 240 taaagtactt ggagtctgca ggtgcgagag ttgtaccagt aaggctggat cttacagaga 300 aagactatga aatacttttc aaatctatta atggaatcct tttccctgga ggaagtgttg 360 acctcagacg ctcagattat gctaaagtgg ccaaaatatt ttataacttg tccatacaga 420 gttttgatga tggagactat tttcctgtgt ggggcacatg ccttggattt gaagagcttt 480 cactgctgat tagtggagag tgcttattaa ctgccacaga tactgttgac gtggcaatgc 540 cgctgaactt cactggaggt caattgcaca gcagaatgtt ccagaatttt cctactgagt 600 tgttgctgtc attagcagta gaacctctga ctgccaattt ccataagtgg agcctctccg 660 tgaagaattt tacaatgaat gaaaagttaa agaagttttt caatgtctta actacaaata 720 cagatggcaa gattgagttt atttcaacaa tggaaggata taagtatcca gtatatggtg 780 tccagtggca tccagagaaa gcaccttatg agtggaagaa tttggatggc atttcccatg 840 cacctaatgc tgtgaaaacc gcattttatt tagcagagtt ttttgttaat gaagctcgga 900 aaaacaacca tcattttaaa tctgaatctg aagaggagaa agcattgatt tatcagttca 960 gtccaattta tactggaaat atttcttcat ttcagcaatg ttacatattt gattgaaagt 1020 cttcaatttg ttaacagagc aaatttgaat aattccatga ttaaactgtt agaataactt 1080 gctactcatg gcaagattag gaagtcacag attcttttct ataatgtgcc tggctctgat 1140 tcttcattat gtatgtgact atttatataa cattagataa ttaaatagtg agacataaat 1200 agagtgcttt ttcatggaaa agccttctta tatctgaaga ttgaaaaata aatttactga 1260 aatacaaaaa aaaaaaaaaa 1280 <210> 9 <211> 1449 <212> DNA <213> Homo sapiens <400> 9 gacatgacac cagtggcata tcacggccat ggggtctcag cattccgctg ctgctcgccc 60 ctcctcctgc aggcgaaagc aagaagatga cagggacggt ttgctggctg aacgagagca 120 ggaagaagcc attgctcagt tcccatatgt ggaattcacc gggagagata gcatcacctg 180 tctcacgtgc caggggacag gctacattcc aacagagcaa gtaaatgagt tggtggcttt 240 gatcccacac agtgatcaga gattgcgccc tcagcgaact aagcaatatg tcctcctgtc 300 catcctgctt tgtctcctgg catctggttt ggtggttttc ttcctgtttc cgcattcagt 360 ccttgtggat gatgacggca tcaaagtggt gaaagtcaca tttaataagc aagactccct 420 tgtaattctc accatcatgg ccaccctgaa aatcaggaac tccaacttct acacggtggc 480 agtgaccagc ctgtccagcc agattcagta catgaacaca gtggtcagta catatgtgac 540 tactaacgtc tcccttattc cacctcggag tgagcaactg gtgaatttta ccgggaaggc 600 cgagatggga ggaccgtttt cctatgtgta cttcttctgc acggtacctg agatcctggt 660 gcacaacata gtgatcttca tgcgaacttc agtgaagatt tcatacattg gcctcatgac 720 ccagagctcc ttggagacac atcactatgt ggattgtgga ggaaattcca cagctattta 780 acaactgcta ttggttcttc cacacagcgc ctgtagaaga gagcacagca tatgttccca 840 aggcctgagt tctggaccta cccccacgtg gtgtaagcag aggaggaatt ggttcactta 900 actcccagca aacatcctcc tgccacttag gaggaaacac ctccctatgg taccatttat 960 gtttctcaga accagcagaa tcagtgccta gcctgtgccc agcaaatagt tggcactcaa 1020 taaagatttg cagaatttaa tacagatctt ttcagctgtt cttagggcat tataaatgga 1080 aatcataacg tggttctagg ttatcaaacc atggagtgat gtggagctag gattgtgagt 1140 gacctgcagg ccattatcag tgcctcatct gtgcagaagt ggcagcagag agggaccatc 1200 caaataccta agagaaaaca gacctagtca ggatatgaat ttgtttcagc tgttcccaaa 1260 ggcctgggag ctttttgaaa agaaagaaaa aagtgtgttg gctttttttt ttttttagaa 1320 agttagaatt gtttttacca agagtctatg tggggcttga ttcacccttc atccattggc 1380 tggaacatgg attggggatt tgatagaaaa ataaaccctg cttttgattc aaaaaaaaaa 1440 aaaaaaaaa 1449 <210> 10 <211> 945 <212> DNA <213> Homo sapiens <400> 10 ctgggtgtac agcgtcctcg aaaccacgag caagtgagca gatcctccga ggcaccaggg 60 actccagccc atgccatggc ggattctgag cgcctctcgg ctcctggctg ctgggccgcc 120 tgcaccaact tctcgcgcac tcgaaaggga atcctcctgt ttgctgagat tatattatgc 180 ctggtgatcc tgatctgctt cagtgcctcc acaccaggct actcctccct gtcggtgatt 240 gagatgatcc ttgctgctat tttctttgtt gtctacatgt gtgacctgca caccaagata 300 ccattcatca actggccctg gagtgatttc ttccgaaccc tcatagcggc aatcctctac 360 ctgatcacct ccattgttgt ccttgttgag agaggaaacc actccaaaat cgtcgcaggg 420 gtactgggcc taatcgctac gtgcctcttt ggctatgacg cctatgtcac cttccccgtt 480 cggcagccaa gacatacagc agcccccact gaccccgcag atggcccggt gtaggcgaac 540 ttccctcatt tctctctgca atctgcaaat aactcctcca ttgaaataac tcctccccac 600 cccaacaaca acattcccag cagaccaact cccaccccct ctttgaggta aaagtgcctt 660 tattgggaga cttttgtctt ccagcctgcc aatcaaccct cctgggtgtg gccaccatat 720 gtgtgtgcct aggtcctcct tctgcacgat ccaataggag acaccagttc tgactgaacc 780 atgcccccac ctaagtcaca aaatgaggga agtggggagt tagatttcag agtccaggcc 840 ctaggttggg acccactcca aataatctcc tcggtgtggg tggtggttct atagagggat 900 aaatgaataa taaacattgt taaaatataa aaaaaaaaaa aaaaa 945 <210> 11 <211> 4574 <212> DNA <213> Homo sapiens <400> 11 ggcggctgct cccattgagc tgtctgctcg ctgtgcccgc tgtgcctgct gtgcccgcgc 60 tgtcgccgct gctaccgcgt ctgctggacg cgggagacgc cagcgagctg gtgattggag 120 ccctgcggag agctcaagcg cccagctctg cccgaggagc ccaggctgcc ccgtgagtcc 180 catagttgct gcaggagtgg agccatgagc tgcgtcctgg gtggtgtcat ccccttgggg 240 ctgctgttcc tggtctgcgg atcccaaggc tacctcctgc ccaacgtcac tctcttagag 300 gagctgctca gcaaatacca gcacaacgag tctcactccc gggtccgcag agccatcccc 360 agggaggaca aggaggagat cctcatgctg cacaacaagc ttcggggcca ggtgcagcct 420 caggcctcca acatggagta catgacctgg gatgacgaac tggagaagtc tgctgcagcg 480 tgggccagtc agtgcatctg ggagcacggg cccaccagtc tgctggtgtc catcgggcag 540 aacctgggcg ctcactgggg caggtatcgc tctccggggt tccatgtgca gtcctggtat 600 gacgaggtga aggactacac ctacccctac ccgagcgagt gcaacccctg gtgtccagag 660 aggtgctcgg ggcctatgtg cacgcactac acacagatag tttgggccac caccaacaag 720 atcggttgtg ctgtgaacac ctgccggaag atgactgtct ggggagaagt ttgggagaac 780 gcggtctact ttgtctgcaa ttattctcca aaggggaact ggattggaga agccccctac 840 aagaatggcc ggccctgctc tgagtgccca cccagctatg gaggcagctg caggaacaac 900 ttgtgttacc gagaagaaac ctacactcca aaacctgaaa cggacgagat gaatgaggtg 960 gaaacggctc ccattcctga agaaaaccat gtttggctcc aaccgagggt gatgagaccc 1020 accaagccca agaaaacctc tgcggtcaac tacatgaccc aagtcgtcag atgtgacacc 1080 aagatgaagg acaggtgcaa agggtccacg tgtaacaggt accagtgccc agcaggctgc 1140 ctgaaccaca aggcgaagat ctttggaact ctgttctatg aaagctcgtc tagcatatgc 1200 cgcgccgcca tccactacgg gatcctggat gacaagggag gcctggtgga tatcaccagg 1260 aacgggaagg tccccttctt cgtgaagtct gagagacacg gcgtgcagtc cctcagcaaa 1320 tacaaacctt ccagctcatt catggtgtca aaagtgaaag tgcaggattt ggactgctac 1380 acgaccgttg ctcagctgtg cccgtttgaa aagccagcaa ctcactgccc aagaatccat 1440 tgtccggcac actgcaaaga cgaaccttcc tactgggctc cggtgtttgg aaccaacatc 1500 tatgcagata cctcaagcat ctgcaagaca gccgtgcacg cgggagtcat cagcaacgag 1560 agtgggggtg acgtggacgt gatgcccgtg gataaaaaga agacctacgt gggctcgctc 1620 aggaatggag ttcagtctga aagcctgggg actcctcggg atggaaaggc cttccggatc 1680 tttgctgtca ggcagtgaat ttccagcacc aggggagaag gggcgtcttc aggagggctt 1740 cggggttttg cttttatttt tattttgtca ttgcggggta tatggagagt caggaaactt 1800 cctttgactg atgttcagtg tccatcactt tgtggcctgt gggtgaggtg acatctcatc 1860 ccctcactga agcaacagca tcccaaggtg ctcagccgga ctccctggtg cctgatcctg 1920 ctggggcccg ggggtctcca tctggacgtc ctctctcctt tagagatctg agctgtctct 1980 taaaggggac agttgcccaa aatgttcctt gctatgtgtt cttctgttgg tggaggaagt 2040 tgatttcaac ctccctgcca aaagaacaaa ccatttgaag ctcacaattg tgaagcattc 2100 acggcgtcgg aagaggcctt ttgagcaagc gccaatgagt ttcaggaatg aagtagaagg 2160 tagttattta aaaataaaaa acacagtccg tccctaccaa tagaggaaaa tggttttaat 2220 gtttgctggt cagacagaca aatgggctag agtaagaggg ctgcgggtat gagagacccc 2280 ggctccgccc tggcacgtgt ccttgctggc ggcccgccac aggccccctt caatggccgc 2340 attcaggatg gctctataca cagcagtgct ggtttatgta gagttcagca gtcacttcag 2400 agatgtatct tgtctttgtc aggcccttca tcttcatggc ccacctgttt tctgccgtga 2460 cctttggtcc cattgaggac taaggatcgg gaccctttct ttacccccta cccattgtgg 2520 ctcccaccct gcctcggact ggtttacgtg tcctggttca cacccaggac ttttctttgc 2580 aagcgaacct gtttgaagcc caagtcttaa ctcctggtct cgtaaggttc cactgagacg 2640 agatgtctga gaacaaccaa agaaggcctg ctctttgctg cttttaaaaa atgacaatta 2700 aatgtgcaga ttccccacgc acccgatgac ctattttttc agccgtggga ggaatggagt 2760 ctttggtaca ttcctcaccg aggttagcag ctcagtttgt ggttatgaaa ccgtctgtgg 2820 cctcatgaca gcgagagatg ggaatacact agaaggatct cttttcctgt tttcgtgaaa 2880 cgactcttgc caaacgttcc cgaggcgcca aggagtgtag tacaccctgg ctgccatcac 2940 tctataaaag tgcttcatga gcccagacca aaagcccaca gtgaaatgaa gtaccctttt 3000 gtaaatagca tttttttgca gaaggtgaaa attccactct ctaccaccgg gccagccaat 3060 agatcacttt ggtgaatgct agtttcaaat ttgattcaaa atatttctta ggtgaaagaa 3120 ctagcagaaa gtcaaaaact aagatactgt agactggaca agaaattcta cctgggcacc 3180 taggtgatgc cttctttctt tgattgcctt tctaataaat gcagaatctg aaggtaaata 3240 ggtttaaaac aaaacaaaaa cccacccctt taaggagttg gtaaaaagca gttcaactct 3300 tagcttgact gagctaaaat tcacaggact acgtgctttg tgcattgtag tctagtcgta 3360 attcataggt actgactcct cagccccaaa tgtcggagag gaagaattcg gtcagcctgt 3420 caggtcgtga gtccagttac caccaaacat ctgggaaact tctgggtgct gggtgctctg 3480 ctgctggact tttgtggctg tgtctgtgtc tgcaagataa attagatcgc cctgtggggt 3540 ttgcagaatt agtgaagggt ccaggacgat cccagtgggc tcgcttccaa agcatcccac 3600 tcaagggaga cttgaaactt ccagtgtgag ttgaccccat catttaaaaa taaagtcccc 3660 gggttcctta atgcctcctt cactgggcct tcctagcagg atagaaagtc cttgcccaga 3720 gcaggacctg gctgtctttt tttttttttt tttcccgaga ccaagtttca ctctgttgcc 3780 caaggtagag tgcagtggcg tgatctctgc tcattgcaac tgccgcctcc cgggttcaag 3840 caattctcat gcatcagcct cccaagtacc tgggactaca ggcgtgagct accatgcccg 3900 gctaattttt gtatttttag tagagatggg gtttcattat gttggccagg ctggtctcga 3960 actccttacc tcaggtgatc cacccacctt ggcctcccga agtgctggga ttacaggcat 4020 gagccactgc gcccggccat ggacctggct gtctttatca tccccacaaa cattttgaaa 4080 ctggaatatt tgtcttcaga aaatggaaac aagactataa atgataagcc ctgtccctag 4140 caccacctct cctgtgtgtg gaatagaggc ccctcgtgct accaacactt accctgtgtt 4200 taaaaagatc ttgtaccaag ccaacggcgt tcctggctct cctgcccaca ggatgaacat 4260 tttcggcttc cttaggagtt ttgccctacc gtattccaaa gcgtgtgctg gtttctcata 4320 ttgtctgtag gctcactcag cccgcagttt atgtgtgtgc ttttttctat gaaaaatgat 4380 gtattttgct acttcctgtg tacaaagttt tattgtaaat gttttttgtg ctttgcatga 4440 acaggggcca cgttgttgca attgtttcag tagaactggt ttgatttcta aaatgttcct 4500 gtaacatatc ttttatgaac aaatctgaac aatttgtgaa ataaaacatt gaaaaccaaa 4560 aaaaaaaaaa aaaa 4574 <210> 12 <211> 3414 <212> DNA <213> Homo sapiens <400> 12 gcttacacag tatggccggc gacattagct agcgctcgct ctactctctc taacgggaaa 60 gcagcggaat acaagagact gaactgtatc tgcctctatt tccaaaagac tcacgttcaa 120 ctttcgctca cacaaagccg ggaaaatttt attagtcctt tttttaaaaa aagttaatat 180 aaaattatag caaaaaaaaa aaggaacctg aactttagta acacagctgg aacaatcgca 240 gcggcggcgg cagcggcggg agaagaggtt taatttagtt gattttctgt ggttgttggt 300 tgttcgctag tctcacggtg atggaagctg cacatttttt cgaagggacc gagaagctgc 360 tggaggtttg gttctcccgg cagcagcccg acgcaaacca aggatctggg gatcttcgca 420 ctatcccaag atctgagtgg gacatacttt tgaaggatgt gcaatgttca atcataagtg 480 tgacaaaaac tgacaagcag gaagcttatg tactcagtga gagtagcatg tttgtctcca 540 agagacgttt cattttgaag acatgtggta ccaccctctt gctgaaagca ctggttcccc 600 tgttgaagct tgctagggat tacagtgggt ttgactcaat tcaaagcttc ttttattctc 660 gtaagaattt catgaagcct tctcaccaag ggtacccaca ccggaatttc caggaagaaa 720 tagagtttct taatgcaatt ttcccaaatg gagcaggata ttgtatggga cgtatgaatt 780 ctgactgttg gtacttatat actctggatt tcccagagag tcgggtaatc agtcagccag 840 atcaaacctt ggaaattctg atgagtgagc ttgacccagc agttatggac cagttctaca 900 tgaaagatgg tgttactgca aaggatgtca ctcgtgagag tggaattcgt gacctgatac 960 caggttctgt cattgatgcc acaatgttca atccttgtgg gtattcgatg aatggaatga 1020 aatcggatgg aacttattgg actattcaca tcactccaga accagaattt tcttatgtta 1080 gctttgaaac aaacttaagt cagacctcct atgatgacct gatcaggaaa gttgtagaag 1140 tcttcaagcc aggaaaattt gtgaccacct tgtttgttaa tcagagttct aaatgtcgca 1200 cagtgcttgc ttcgccccag aagattgaag gttttaagcg tcttgattgc cagagtgcta 1260 tgttcaatga ttacaatttt gtttttacca gttttgctaa gaagcagcaa caacagcaga 1320 gttgattaag aaaaatgaag aaaaaacgca aaaagagaac acatgtagaa ggtggtggat 1380 gctttctaga tgtcgatgct gggggcagtg ctttccataa ccaccactgt gtagttgcag 1440 aaagccctag atgtaatgat agtgtaatca ttttgaattg tatgcattat tatatcaagg 1500 agttagatat cttgcatgaa tgctctcttc tgtgtttagg tattctctgc cactcttgct 1560 gtgaaattga agtggatgta gaaaaaacct tttactatat gaaactttac aacacttgtg 1620 aaagcaactc aatttggttt atgcacagtg taatatttct ccaagtatca tccaaaattc 1680 cccacagaca aggctttcgt cctcattagg tgttggcctc agcctaaccc tctaggactg 1740 ttctattaaa ttgctgccag aattttacat ccagttacct ccactttcta gaacatattc 1800 tttactaatg ttattgaaac caatttctac ttcatactga tgtttttgga aacagcaatt 1860 aaagtttttc ttccatagtt gagtccttag aaaatgattc cagttactca ttttgcatat 1920 tgctatttaa cattattgga ccctgcattt atagtccttt gatttcttcc ctctccctgg 1980 tgtctccccc aagaccccaa ataaagcaat accctgttaa cactgtgggt ttatatacta 2040 attctatacc ccagatgggg aattaggggg gagatggtcc ctgggcttaa tattctttaa 2100 agggcatggg aatttagcct ctcttttatt gtaatgtgct cttttggaaa atagttggtt 2160 agcagggaga ccagagttgt agattgagat tgggtgtact ggctgttctg tggaaaacat 2220 acattctgtg ttcctcgaat aagtgaaatt gagcttctaa tgagatgcac ccctttacta 2280 acttgatgat gatataaaat tcatttttat ttagttaatt accagagaga tttagcataa 2340 ttttgcttct ggattcagta aatcaagtca gcttggatca ttcaccttaa cttttccttt 2400 agcagccctt tccactagtt tcccattaag tagtgttcta taaactttga tccaaagcag 2460 aatcaatgtc ttttccatct cgtgacttaa agttctgtga ctgtgatgca tgtgagtgtt 2520 ccgacttcat ctgttcctct taactacggt gtttccctta ccgatcggca ttcataggat 2580 gaaatgaatg actgtcccag aatgagaatt tgtccagatt attcagataa acatcataaa 2640 gagaataaca ttataaataa gtagaatatg aataaataga ataataaaat tccaaaatac 2700 tcaatgggaa atgactagta atataggctt tcaagagttg gtacctttac gtatatttgc 2760 agattctctg ggattttaag gaactgagaa aacagaaaag ttgactaaat tttatatttc 2820 ttgtcctcta aatattttga taatttctgg attgatgcag tgatgttttt cgttccttgt 2880 atttataaat gaaaaccttt ttttggtgtt tctaaaccta aaatctactt ggtttgaaat 2940 caagtggttg gaacactgtt tgacttttat ttgaagcatg ttgttgattg aaaatttcat 3000 tgaggaagtt ttcaatcagt gtgatcagtt tgattctgta atgagcacag cacctaatat 3060 tttgaggagc tctgttttga ggaccaatgc ttaaggtgga ccttgttgct aaacaatatc 3120 ccaatagatt tgttgacttg aggtctggtt tggttttgtt tttgttttgt tttggttttg 3180 ttttgtttcc caatagaatt aagaattcta atgttgaaaa actgtataaa tttttatggg 3240 acaaagccta gaaaagagaa atgtagtttg aatcataatc taaatcatcg tatgatagga 3300 aggaaaagtt ttggtgccat aatttctcct ttcactggtg ttggacttaa atcagttgaa 3360 atgtatttct gtaccacaat ttacgcttca ataaaagttt aattgtctag tgag 3414 <210> 13 <211> 1558 <212> DNA <213> Homo sapiens <400> 13 gagtgcaaag cgctctccct ccctcgccca gccttcgtcc tcctggcccg ctcctctcat 60 ccctcccatt ctccatttcc cttccgttcc ctccctgtca gggcgtaatt gagtcaaagg 120 caggatcagg ttccccgcct tccagtccaa aaatcccgcc aagagagccc cagagcagag 180 gaaaatccaa agtggagaga ggggaagaaa gagaccagtg agtcatccgt ccagaaggcg 240 gggagagcag cagcggccca agcaggagct gcagcgagcc gggtacctgg actcagcggt 300 agcaacctcg ccccttgcaa caaaggcaga ctgagcgcca gagaggacgt ttccaactca 360 aaaatgcagg ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca 420 ttcattttca tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa 480 aaaaaagtga agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt 540 ggagactgtg ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc 600 atgaagaccc agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc 660 aaataccagt tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact 720 ggaagtctga agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag 780 ccctgtggca aactgaccaa gcccaaacct caagcagaat ctaagaagaa gaaaaaggaa 840 ggcaagaaac aggagaagat gctggattaa aagatgtcac ctgtggaaca taaaaaggac 900 atcagcaaac aggatcagtt aactattgca tttatatgta ccgtaggctt tgtattcaaa 960 aattatctat agctaagtac acaataagca aaaacaaaaa gaaaagaaaa tttttgtagt 1020 agcgtttttt aaatgtatac tatagtacca gtaggggctt ataataaagg actgtaatct 1080 tatttaggaa gttgacttat agtacatgat aaatgataga caattgaggt aagttttttg 1140 aaattatgtg acattttaca ttaaattttt tttacatttt ttgggcagca atttaaatgt 1200 tatgactatg taaactactt ctcttgttag gtaatttttt tcacctagat ttttttccca 1260 attgagaaaa atatatacta aacaaaatag caataaaaca taatcactct atttgaagaa 1320 aatatcttgt tttctgccaa tagatttttt aaaatgtagt cagcaaaatg ggggtgggga 1380 agcagagcat gtcctagttc aatgttgact tttttttttt ttaaagaaaa gcattaagac 1440 ataaaattct ttcactttgg cagaagcatt tgttttcttg atgaaattat ttttccatct 1500 gaggaaaaaa atactaggaa aataaatcaa ggtgatgctg aaaaaaaaaa aaaaaaaa 1558 <210> 14 <211> 1416 <212> DNA <213> Homo sapiens <400> 14 acgggctatt taaaggtacg cgccgcggcc aaggccgcac cgtactgggc gggggtctgg 60 ggagcgcagc agccatggca agccgtctcc tgctcaacaa cggcgccaag atgcccatcc 120 tggggttggg tacctggaag tcccctccag ggcaggtgac tgaggccgtg aaggtggcca 180 ttgacgtcgg gtaccgccac atcgactgtg cccatgtgta ccagaatgag aatgaggtgg 240 gggtggccat tcaggagaag ctcagggagc aggtggtgaa gcgtgaggag ctcttcatcg 300 tcagcaagct gtggtgcacg taccatgaga agggcctggt gaaaggagcc tgccagaaga 360 cactcagcga cctgaagctg gactacctgg acctctacct tattcactgg ccgactggct 420 ttaagcctgg gaaggaattt ttcccattgg atgagtcggg caatgtggtt cccagtgaca 480 ccaacattct ggacacgtgg gcggccatgg aagagctggt ggatgaaggg ctggtgaaag 540 ctattggcat ctccaacttc aaccatctcc aggtggagat gatcttaaac aaacctggct 600 tgaagtataa gcctgcagtt aaccagattg agtgccaccc atatctcact caggagaagt 660 taatccagta ctgccagtcc aaaggcatcg tggtgaccgc ctacagcccc ctcggctctc 720 ctgacaggcc ctgggccaag cccgaggacc cttctctcct ggaggatccc aggatcaagg 780 cgatcgcagc caagcacaat aaaactacag cccaggtcct gatccggttc cccatgcaga 840 ggaacttggt ggtgatcccc aagtctgtga caccagaacg cattgctgag aactttaagg 900 tctttgactt tgaactgagc agccaggata tgaccacctt actcagctac aacaggaact 960 ggagggtctg tgccttgttg agctgtacct cccacaagga ttaccccttc catgaagagt 1020 tttgaagctg tggttgcctg ctcgtcccca agtgacctat acctgtgttt cttgcctcat 1080 ttttttcctt gcaaatgtag tatggcctgt gtcactcagc agtgggacag caacctgtag 1140 agtggccagc gagggcgtgt ctagcttgat gttggatctc aagagccctg tcagtagagt 1200 agaagtctct tccagtttgc tttgcccttc tttctaccct gctggggaaa gtacaacctg 1260 aatacccttt tctgaccaaa gagaagcaaa atctaccagg tcaaaatagt gccactaacg 1320 gttgagtttt gactgcttgg aactggaatc ctttcagcaa gacttctctt tgcctcaaat 1380 aaaaagtgct tttgtgagaa aaaaaaaaaa aaaaaa 1416 <210> 15 <211> 6400 <212> DNA <213> Homo sapiens <400> 15 ctgagatgca ggcccagcgc tggcgcagtg agaacttcga gagacccgtg gacctggagg 60 gctctgggga tgatgactcc tttcccgatg atgaactgga tgacctctac tcggggtcgg 120 gctcgggctg taagtacccc cctccctacc tctgcctggg ggcagtgacc agtctgtatc 180 cagcctcaac tctgagaagc ccacgggggg cttgcttcag tgaggcaggg ggcattcact 240 gcctgggtca ggcaagttct tcttgctctg gatccccaga acaagaaggg cagaacatcc 300 ttctggggat agaacaagac ctgggaggac ctcagggccc agaatgtcca ggtctccagg 360 gtcccacgtc tgcatctttg tgtgtgctat gtggctttct ctgcagacct tgcttggttc 420 cggtggtccc gtcaggtgca ataagctgtg gccaatggtg gggttagggc agtgatgaca 480 cagggcaggt gcttcaagtg gtgcctggga tggccccgcc ctggggaagg ggagccaggt 540 cagctgggtc tagcagaatc tcgggagaga agggcaccgc gaaccccact ctgccatgta 600 gcaactgtgt gcccctcggt gctccccctc cctgaatccc tgtattttca cctgtggatg 660 gtgagaaata cgacttcttc tcagtgcctc taggagggtt tgggatagga agctggggtc 720 tggcacagag gaggagctct caaaatggta gcaaaaagaa ggcagctgag actgggccca 780 gtgagggcac gggctggcat ctgaggagat ggtacggggt ctgcacgcca cagagctggc 840 tccccacagc cctcgcctct ggtctcccct ccttagccaa gtcctttgag cctctttcaa 900 attaatcttt gtaaaacccg tttatattgg gtcacatctc tattcgcaaa gttccctggc 960 tcccctccct cctgcctggt tccgagccca ggagctggct gtggcttctc cctcccccat 1020 cccctactcc ccgtctcatt tcctcccaag ttccttcact gtcccggctt tgcgtcagcc 1080 agattgctca agcagttccc ctgcctcaag ggcttctttt cccttttacc ctccgcctct 1140 gcctctgggg gaagccctta gtgtaccacc cctgccttga gcttgtggta ggggtgcctt 1200 tggggtctga ctcttcccag aatgccactc ctgtgttccc ctgcaagccc cagcaagttt 1260 tgcagccagt agcgcctcag ttgctgctgc ctggattcaa cctcatagaa actgtaggct 1320 gggtgggcag gaatagtcaa ggaaggcttc ccgggagagg cggcccccag aatttttgac 1380 ttggcagaga gaagttgggg aacatcagca actgaccacc tttagctggc tgtgccttcc 1440 tcctttctct catcttttct gggaaaattg ggtaaagaga gggggttggg agacctaatc 1500 ttgatggcca ttgcttacct gggatcctca tgcccctcac aaccacccag ctccctagct 1560 ctctccctct cccccacccc ctcagacttc gagcaggagt cgggcattga gacagccatg 1620 cgcttcagcc cagatgtagc cctggcggtg tccaccacac ctgcggtgct gcccaccacg 1680 aacatccagc ctgtgggcac accatttgaa gagctcccct ctgagcgccc caccctggag 1740 ccagccacca gccccctggt ggtgacagaa gtcccggaag agcccagcca gagagccacc 1800 accgtctcca ctaccatggc taccactgct gccacaagca caggggaccc gactgtggcc 1860 acagtgcctg ccacagtggc caccgccacc cccagcaccc ctgcagcacc cccttttacg 1920 gccaccactg ctgttataag gaccactggc gtacggaggc ttctgcctct cccactgacc 1980 acagtggcta cggcacgggc cactaccccc gaggcgccct ccccgcccac cacggcggct 2040 gtcttggaca ccgaggcccc aacacccagg ctggtcagca cagctacctc ccggccaaga 2100 gcccttccca ggccggccac cacccaggag cctgacatcc ctgagaggag caccctgccc 2160 ctggggacca ctgcccctgg acccacagag gtggctcaga ccccaactcc agagaccttc 2220 ctgaccacaa tccgggatga gccagaggtt ccggtgagtg gggggcccag tggagacttc 2280 gagctgccag aagaagagac cacacaacca gacacagcca atgaggtggt agctgtggga 2340 ggggctgcgg ccaaggcatc atctccacct gggacactgc ccaagggtgc ccgcccgggc 2400 cctggcctcc tggacaatgc catcgactcg ggcagctcag ctgctcagct gcctcagaag 2460 agtatcctgg agcggaagga ggtgctcgta gctgtgattg tgggcggggt ggtgggcgcc 2520 ctctttgctg ccttcttggt cacactgctc atctatcgta tgaagaaaaa ggatgagggc 2580 agctacacgc tggaggaacc caagcaggcg agcgtcacat accagaagcc tgacaagcag 2640 gaggagttct atgcctagtg gagccacagt gcctccctgc agcctcaaca ccaccctgct 2700 gtccagtccc cagcctggcc ccaccagccc aagcctggga ctgggcctgg aacctggccc 2760 cagttcttct ctgccctctc tcccaaggtc tgcccaggct gccagcctca cacagatctt 2820 ccccgaggaa gaggggctgc tgccatctgc cccagactgt gcccttacga gctcatctct 2880 tgttcccctc atccctgcca ccagtctggg gcttcaggac ctcatgtcag atggatggga 2940 ggaagaaagc tcctgattgg ctggtggtgg aagaaagggt ggggcttgag atgagcctga 3000 gccctgactt ggcacccaca gtgctcactg agatctcctt tttggggcag agaggcactc 3060 aggctggttt ccaggacaaa catttggtaa acacagccct tgaaatcatc tagacactgc 3120 aacctcttgc tcgtatccca gggcctctct ctagctgggt gagagggtgt cccttgtcac 3180 cagcctgttt tgtcctggtc tctctggggt tgttgaatct ctcctcttgc ctgccaagta 3240 cacatgtacc cagacttcat ttctttctgc atcttccccc aagaaacagc ttcctgaggg 3300 tgctggggca gccactggtg aggaggggct gctctgatgt ccctcctatg aggggactct 3360 gcacagacac cattgcccac actatcacca tattttcact cagtcacaca caagacaaaa 3420 gcatgcaatg acaaaaccat acgcaatcct gaccgcccag ccaatcaaga catatcacag 3480 aacacacgcg tccttccaag aatgtttatc ctcatgcatc acttacacac ccccagacac 3540 gtactgcaat gcaagtcact agtcatggtc acatgacagt gacagtgtgg cctcctccta 3600 ccccaaatac acccacactc tggcaccaca cacattgtct ccagctttca ggcttactgg 3660 ggagggtgga atcgagccag aacaatcagc ccatattggg tccccctaag ttgccccgtc 3720 atactcagtc ccatgccatg gtgcccacac caaccatgca gccaccaacc ccagccagtg 3780 tcagacacaa tcccatgtgg atgcacagtc tcactccaca tgacctgctc tcaatgctgg 3840 agggaaacag gcaggccctt gcctttctcg gaaaaagtgt ggggccacag cccttttagg 3900 gcattgcatg caggtgggcc tggcttcacc cctacctgct tcctccccac cgcagctggc 3960 agagggggag gtttggggcc agacccccac tagctgggag cctgggggct cctctaaggc 4020 tgaggaagga aatttggccc caggttgttg gggggtcttg ggtctcccag gacggaaggc 4080 ccagggcagg gagggggcat gtggttgggc tcctttatct ccctgtgtcc ccttcctgct 4140 ttgagctagg gggctgactc tgcctcccag gacacaagtc tccaaagtgc ctgtgagggc 4200 gggccctccg caccctctgc cctctgcctg gcaggccaac ctcagcccac ctgcccagag 4260 gccctccctg tggacacccc ctcacctatt tggccaaaca attctggctg cagcttcagg 4320 ggccatggct ggaagcagcc cctgcagatc cctcaggccc cgaggtcagg gtttgaggga 4380 tgagaccagg tgatagtggg ggaggggtta cttcctttgt tacctagcaa gtagggctat 4440 ttccatcggt attttaaatg tggggtcaca gatcttttgg ggagggtgtg cttggcaggg 4500 ggcctcttgg agccaaaggg atgtggtgtg agttgcgatt ggctggcact cacaccccca 4560 cccctcaccc acatcccaga ttcaagtcag gaaggcaggt tttatttcag ggcccttttc 4620 aagatgccct ggcagcagat ttctgcagga tgaggggtag cggtgtgtag gcagtgaggg 4680 ggaggttcca ggggctgtcc cacagcctgt cttttccagg ctgggctcca tcttccagtc 4740 ccaaaaccct ccttcacagg gcccagaggc ttgtgaggaa gccaggtgga cccagccttg 4800 gaagagtggg catggggggc ccctgatatc tggagggggc gggttggcct cagtcatctt 4860 tggagcagaa gggctgggtc ctggggccac agaccacaag gctcagcctc cctaccctgc 4920 tccctggggt gctgctgtct tggagagcac agctctggtg agacggcctg ggcaggccga 4980 ggctgagaaa ccagggagga tagaggagaa aagggcttgg gcccccagcc ccagaagatg 5040 ctgggcccca ggtgggagac ccaacagtgg gtgcagtttc tcagtggggc tggagccaat 5100 ggtgggggtg gccccggcag gcctggctcc tcacatccca ggggttggct tctgatttgg 5160 ggcttgggct ccaggcactg gcttctcttc tctgtgtcct tagcatttga gagaagaggc 5220 caggggcctt gttcatggat ccctggaccc aaggcagatg tccaggcttt atcctcctga 5280 ggatgaggag tctgaccagc ccaaatctgc cctggccggc ctgaccgggg caaggcagtc 5340 caagagagtt cagtgaggac cagctaggct ctcccaggtg caatgtgggt gcagggccct 5400 catgtccccc tacccctgcc tgtgatggag tgttctgagg ggctttggca tttgctggaa 5460 gcacagggag ttccaaatga gagggagctt ctgtggcttg agagcctctg gggccttggc 5520 tgccagagca cgaggcaggc caggacctgg agagcccaga ccctgtctcc aggaggccag 5580 gaggccagat gggggccttg cctgaaagac tggtcccctt gatcgctgga ggcatgtggg 5640 tggcaaccag ggctgggcag ggcttagggt gtgtgggcca aacccccctg gggttggcaa 5700 agccgcctgt caggcctcct ggtgggggcc cctggacaca gggagcagac cctctgcctc 5760 atggggtagg agtggctgcc tcctgtgttc tctggatttc ttctcccaac aactacaacc 5820 ctggacttgc ctccccaggc ctcttgcctg taaatagaag cccgcaaact gtacagattt 5880 acagaggcat cgagactggg ccctgggagt tgccatctga gagccgatgg ccccagcatc 5940 ccccaggtgc ctgcctggca ccacagtgac cctggcctca gcgtggcaaa tgcatgtaaa 6000 tatttttcgt aggcagcgtg gctccagaga gccccctgaa gacagtgtcc ctccctcctg 6060 tgagtccttt ctcctgtaca gaacctgcct ggggtgggtg ggggtctgcc attccctccc 6 120 ccaggccttc cctgcccctt ctctcccctg taacctgttt attaaccata cctgtcctga 6180 gttcatggcc aaaaccttaa ataagaaaaa caaaagaaaa agacagtgga aaaaagagac 6240 caaggcgcct gccccactgc gggtactctc ctgttccagc cttgtgaagg aactggtttt 6300 gtttttgttt ttgttttttt tttttttgtt tgtttgtttg ttttttaaca cttcctgtgc 6360 tgtgcccatt tataagagga aataaaatta agctgaaatg 6400 <210> 16 <211> 5487 <212> DNA <213> Homo sapiens <400> 16 tctgtcgact tgccccagag ctgatccttg tctttgtcca cttctcagcg aggatggcac 60 ttcagggagc ccttccctta ctatcgcaga gagagcaggc cctccccagt catgtccaac 120 ccagaactct gttttgtttt cttcatagcc ctagcatcac agaaaatcac cctgtgcatt 180 catggatgtc cacgggggca agggctttgt gttgcttaac ccagcatcct gaaccgtgtt 240 tgttgaatga atacagaacc ccgtttgctc tgggagagca cagaaaacag tcttctatca 300 tatatcatag ccagctgcaa acagcagatg gcttcccata tcccagagag taagaaccag 360 agagagagag aaagagagag agtttgggtc tttctcctct gtgcctgctc tctccagaga 420 aactggaggg gtagcagtta gcattccccc gctggttcca ccaagcacag tcaaggtctc 480 taggacatgg ccacccctca cctgtggaag cggtcctgct ggggtgggtg ggtgttagtt 540 ggttctggtt tgggtcagag acacccagtg gcccaggtgg gcgtggggcc agggcgcaga 600 cgagaagggg cacgagggct ccgctccgag gacccagcgg caagcaccgg tcccgggcgc 660 gccccagccc acccactcgc gtgcccacgg cggcattatt ccctataagg atctgaacga 720 tccgggggcg gccccgcccc gttacccctt gcccccggcc ccgccccctt tttggagggc 780 cgatgaggta atgcggctct gccattggtc tgagggggcg ggccccaaca gcccgaggcg 840 gggtccccgg gggcccagcg ctatatcact cggccgccca ggcagcggcg cagagcgggc 900 agcaggcagg cggcgggcgc tcagacggct tctcctcctc ctcttgctcc tccagctcct 960 gctccttcgc cgggaggccg cccgccgagt cctgcgccag cgccgaggca gcctcgctgc 1020 gccccatccc gtcccgccgg gcactcggag ggcagcgcgc cggaggccaa ggttgccccg 1080 cacggcccgg cgggcgagcg agctcgggct gcagcagccc cgccggcggc gcgcacggca 1140 actttggaga ggcgagcagc agccccggca gcggcggcag cagcggcaat gaccccttgg 1200 ctcgggctca tcgtgctcct gggcagctgg agcctggggg actggggcgc cgaggcgtgc 1260 acatgctcgc ccagccaccc ccaggacgcc ttctgcaact ccgacatcgt gatccgggcc 1320 aaggtggtgg ggaagaagct ggtaaaggag gggcccttcg gcacgctggt ctacaccatc 1380 aagcagatga agatgtaccg aggcttcacc aagatgcccc atgtgcagta catccacacg 1440 gaagcttccg agagtctctg tggccttaag ctggaggtca acaagtacca gtacctgctg 1500 acaggtcgcg tctatgatgg caagatgtac acggggctgt gcaacttcgt ggagaggtgg 1560 gaccagctca ccctctccca gcgcaagggg ctgaactatc ggtatcacct gggttgtaac 1620 tgcaagatca agtcctgcta ctacctgcct tgctttgtga cttccaagaa cgagtgtctc 1680 tggaccgaca tgctctccaa tttcggttac cctggctacc agtccaaaca ctacgcctgc 1740 atccggcaga agggcggcta ctgcagctgg taccgaggat gggccccccc ggataaaagc 1800 atcatcaatg ccacagaccc ctgagcgcca gaccctgccc cacctcactt ccctcccttc 1860 ccgctgagct tcccttggac actaactctt cccagatgat gacaatgaaa ttagtgcctg 1920 ttttcttgca aatttagcac ttggaacatt taaagaaagg tctatgctgt catatggggt 1980 ttattgggaa ctatcctcct ggccccaccc tgccccttct ttttggtttt gacatcattc 2040 atttccacct gggaatttct ggtgccatgc cagaaagaat gaggaacctg tattcctctt 2100 cttcgtgata atataatctc tattttttta ggaaaacaaa aatgaaaaac tactccattt 2160 gaggattgta attcccaccc ctcttgcttc ttccccacct caccatctcc cagaccctct 2220 tccctttgcc cttctcctcc aatacataaa ggacacagac aaggaacttg ctgaaaggcc 2280 aaccatttca ggatcagtca aaggcagcaa gcagatagac tcaaggtgtg tgaaagatgt 2340 tatacaccag gagctgccac tgcatgtccc aaccagactg tgtctgtctg tgtctgcatg 2400 taagagtgag ggagggaagg aaggaactac aagagagtcg gagatgatgc agcacacaca 2460 caattcccca gcccagtgat gcttgtgttg accagatgtt cctgagtctg gagcaagcac 2520 ccaggccaga ataacagagc tttcttagtt ggtgaagact taaacatctg cctgaggtca 2580 ggaggcaatt tgcctgcctt gtacaaaagc tcaggtgaaa gactgagatg aatgtctttc 2640 ctctccctgc ctcccaccag acttcctcct ggaaaacgct ttggtagatt tggccaggag 2700 ctttctttta tgtaaattgg ataaatacac acaccataca ctatccacag atatagccaa 2760 gtagatttgg gtagaggata ctatttccag aatagtgttt agctcaccta gggggatatg 2820 tttgtataca catttgcata tacccacatg gggacataag ctaatttttt tacaggacac 2880 agaattctgt tcaatgctgt taaatatgcc aatagtttaa tctcttctat tttgttgtcg 2940 ttgcttgttt gaagaaaatc atgacattcc aagttgacat ttttttttca ttttaattaa 3000 aatttgaaat tctgaacacc gtcagcaccc tctcttccct atcatgggtc atctgacccc 3060 tgtccgtctc cttgtccctg cttcatgttt gggggccttt ctttaactgc cttcctggct 3120 tagctcagat ggcagatgag agtgtagtca agggcctggg cacaggaggg agagctgcag 3180 agtgtcctgc ctgccttggc tggagggaca cctctcctgg gtgtggagac agcttggttc 3240 cctttcccta gctccctggt gggtgaatgc cacctcctga gatcctcacc tcttggaatt 3300 aaaattgttg gtcactgggg aaagcctgag tttgcaacca gttgtagggt ttctgttgtg 3360 tttttttttt tttttttgaa ataaaactat aatataaatt ctcctattaa ataaaattat 3420 tttaagtttt agtgtcaaaa gtgagatgct gagagtaggt gataatgtat attttacaga 3480 gtgggggttg gcaggatggt gacattgaac atgattgctc tctgtctctt ttttcagctt 3540 atgggtattt atcttctatt agtatttgta tcttcagttc attccacttt aggaaacaga 3600 gctgccaatt gaaacagaag aagaaaaaaa aaaaaagcag cagacaacac actgtagagt 3660 cttgcacaca cacaagtgcc caggcaaggt gcttggcaga accgcagagt gggaagagag 3720 taccggcatc gggtttcctt gggatcaatt tcattaccgt gtacctttcc cattgtggtc 3780 atgccatttg gcagggggag aatgggaggc ttggccttct ttgtgaggca gtgtgagcag 3840 aagctgatgc cagcatgtca ctggttttga agggatgagc ccagacttga tgttttggga 3900 ttgtccttat tttaacctca aggtctcgca tggtggggcc cctgaccaac ctacacaagt 3960 tccctcccac aagtggacat cagtgtcttc tctgtgaggc atctggccat tcgcactccc 4020 tggtgtggtc agcctctctc acacaaggag gaacttgggt gaaggctgag tgtgaggcac 4080 ctgaagtttc cctgcggagt cgataaatta gcagaaccac atccccatct gttaggcctt 4140 ggtgaggagg ccctgggcaa agaagggtct ttcgcaaagc gatgtcagag ggcggttttg 4200 agctttctat aagctatagc tttgtttatt tcacccgttc acttactgta taatttaaaa 4260 tcatttatgt agctgagaca cttctgtatt tcaatcatat catgaacatt ttattttgct 4320 aaatcttgtg tcatgtgtag gctgtaatat gtgtacattg tgtttaagag aaaaatgaaa 4380 cccacatgcc gccattttcc tgaatcaaat tctgcagtgg aatggagagg aaaatacttc 4440 taggcaagca gctagactgg tgaattgggg gaaatagaag gaactagtaa ctgagactcc 4500 tccagcctcc tccctattgg aatcccaatg gctcctggag taggaaaaaa gtttaaacta 4560 cattcatgtt cttgttctgt gtcactcggc cctgggtagt ctaccattta cttcacccca 4620 agtcctgctg cccatccagt tgggaagcca tgattttcct aagaatccag ggccatggga 4680 gatacaattc caagttctcg cttcctcctt tgggcatctc ttctgcctcc caatcaagga 4740 agctccatgc tcaggctctc agctctcggg ccagtgctct gctctgtcca gggtaggtaa 4800 tactgggaga ctcctgtctt ttaccctccc ctcgttccag acctgcctca tggtggcaac 4860 atggttcttg aacaattaaa gaaacaaatg actttttgga atagccctgt ctagggcaaa 4920 ctgtggcccc caggagacac tacccttcca tgccccagac ctctgtcttg catgtgacaa 4980 ttgacaatct ggactacccc aagatggcac ccaagtgttt ggcttctggc tacctaaggt 5040 taacatgtca ctagagtatt tttatgagag acaaacatta taaaaatctg atggcaaaag 5100 caaaacaaaa tggaaagtag gggaggtgga tgtgacaaca acttccaaat tggctctttg 5160 gaggcgagag gaaggggaga acttggagaa tagtttttgc tttgggggta gaggcttctt 5220 agattctccc agcatccgcc tttcccttta gccagtctgc tgtcctgaaa cccagaagtg 5280 atggagagaa accaacaaga gatctcgaac cctgtctaga aggaatgtat ttgttgctaa 5340 atttcgtagc actgtttaca gttttcctcc atgttattta tgaattttat attccgtgaa 5400 tgtatattgt cttgtaatgt tgcataatgt tcacttttta tagtgtgtcc tttattctaa 5460 acagtaaagt ggttttattt ctatcac 5487 <210> 17 <211> 4934 <212> DNA <213> Homo sapiens <400> 17 gcgagctgag ctgacagcgc ggagctggcg ctgtggagcg cagggagcct tgccggttcc 60 tccgaccggc gtctgcgagt acagcggcgg ctaacctgcc ccggcttcag gatttacaca 120 gacgtggggc gatgcttgtg accctgcagc tcctcaaacc agcctgtatt gagcggtttg 180 cagcctgatg ctcagccccc tccccacagg gcccctagaa gcctgtttct ccgtacagtc 240 caggacctcc agccccatgg agcccccgat cccacagagc gcccccttga ctcccaactc 300 agtcatggtc cagccccttc ttgacagccg gatgtcccac agccggctcc agcacccact 360 caccatccta cccattgacc aggtgaagac cagccatgtg gagaatgact acatagacaa 420 ccctagcctg gccctgacca ccggcccaaa gcggacccgg ggcggggccc cagagctggc 480 cccgacgccc gcccgctgtg accaggatgt cacccaccat tggatctcct tcagcgggcg 540 ccccagctct gtgagcagca gcagcagcac atcctctgac caacggctct tagaccacat 600 ggcaccacca cccgtggctg accaggcctc accaagggct gtgcgcatcc agcccaaggt 660 ggtccactgc cagccgctgg acctcaaggg cccggcggtc ccacccgagc tggacaagca 720 cttcttgctg tgcgaggcct gtgggaagtg taaatgcaag gagtgtgcat ccccccggac 780 gttgccttcc tgctgggtct gcaaccagga gtgcctgtgc tcagcccaga ctctggtcaa 840 ctatggcacg tgcatgtgtt tggtgcaggg catcttctac cactgcacga atgaggacga 900 tgagggctcc tgcgctgacc acccctgctc ctgctcccgc tccaactgct gcgcccgctg 960 gtccttcatg ggtgctctct ccgtggtgct gccctgcctg ctctgctacc tgcctgccac 1020 cggctgcgtg aagctggccc agcgtggcta cgaccgtctg cgccgccctg gttgccgctg 1080 caagcacacg aacagcgtca tctgcaaagc agccagcggg gatgccaaga ccagcaggcc 1140 cgacaagcct ttctgacagt ttgtgtcgaa gccccagtgc tctgcctgga aacctggttc 1200 tcttctgaca tctaagaaga ctgcagcaag gtcagaggtt ttagcctcct gaggctgacc 1260 ttgctagtct gcccactccc tacccccagc ttcggaaaat acagagacca ccaccacgta 1320 ccctgtattc cccaaggtga tgaagaagca ctttggggct ttttttcagg gtcctgaaac 1380 tttgtgtcaa acagacaatg caggggcagg gtgtggtttg gggggaaatt tttctttttc 1440 agaagacaga acacagatgt ggacacatat ccggaaactg cagctgcttg aatgccttcc 1500 cagcccctcc ttctccctcc ctccctccgc cccccccttc ctcttttcca ttgtctttgg 1560 ctctcacagg agctagctgc ctgggaggaa ttgttaactg agtaccaggg tacctttaaa 1620 gaagaccctt ggagtcttct ataccttctt ctccttcccc atctcactcc accccacttt 1680 gtccctgatg tcttggggaa ggtgtagaac accctagcag ttcctattgt atatacttgg 1740 gagccactga gaacagagga cggccagtga gtccaagcct cgttcctcct tctgcctccc 1800 cggagccaca ggatggattt aggagccact gctcagtgca cttctccctt ccaactgcat 1860 caactaactc tcgggggtgt tctgctcacc acaccgtcct tcggttctta ctgagtcaca 1920 gactcgcctg cccactacgt gtcctgggtt ctctactcag atcccttcca gaaactttat 1980 atgggtagag gaagccaggg cggcaaatgc gagaccaaat atcattttgc caatgagtct 2040 gaggctgtgg tctctggatc cagtcattat gtttttatag aataattaaa ccggatgcta 2100 acggtgtttt aaaaaataat aataaaacaa cttgtttcct tttggccacc cccaggaagg 2160 gctgatttca aaatctgggg gcgagcaacc tcaaggaaca caatttccct ccctatcaac 2220 aagaggattt taacagcaaa gaagagaggc agcacctccc attggcagaa tgaccgctga 2280 gccaggctgg gtttgggttt cttctcttct gattctgctg ctcactgtca tagccttttg 2340 tgtatagtga tgtgtctgta tctttaatgt aaatagagag atgatgaaaa aagagtctat 2400 tttagtgtta ggaagcccca gcaggggagt cggaagagct tggaagagct ggggagaggg 2460 taggggaaag gtttttccag gggccactgg gtttgagccc tgcttctgtg cacagccaca 2520 ccaccctctc ccgacagccc tcaaagacgt agcaactctt tctctcaagg tgctaaagga 2580 ctcagaaggt gcagcacgtc cagtgggtag gtacttgttg catgcaaaag ctgtagtgta 2640 tctggtcctt cctccccagc ttttgtgtgg ggttcttgct ttgtgtggta ttttgttttc 2700 ccctctaatg agagggcatg gcctgagtca gaagagctac cccaggtgaa actggaagtg 2760 catgaggcag agcgtccgta gcatttccag tttgttctgt ataggacaga ggtgcctccg 2820 ggaaggaggc agcgaggtag gtagctatga taggcaccta atgcttctca aggacttatt 2880 ttttccttct tgaagactag tagtaacatc ttatgattta gagtaagttg attgtaacca 2940 taggtattta ttgattggag gaagggaggg tcatattatt ttcggcttta tttatgtaac 3000 atttgctagc ttataaaagg cgaatgtgaa atattgcatc tgcattttcc aaggctgatt 3060 cgtgtagcta cccttgccac agttgtgacg gatgtatgga tgttcttgaa catttcagaa 3120 ggagtggtag aaaaaaacac acattcagcc aaccacttat atgaattgaa tgtatcagaa 3180 gtgtactgaa gggactggag atggttttcc tcagatgagg gggccccaaa attgatagtg 3240 cacatctgca cgctttctgc gaggcctcag aacttttccc agggcccctc cctcaaattg 3300 tctccatggg aaacttgacc cagtggcaag ttgcactttg gtgatcttgg tggtctacac 3360 acccgttctg tggagagtcg atttacataa gctgtgtata cacacacaca cacacacaca 3420 cacacacaca cacacacacc cctaccccac actgactgtc taccgacaga gaccctattt 3480 cctggcaaac ggcctcctga accctgactt tttgtgtaca tacttgtaaa cacggatttt 3540 tctgggtttt ggtttgcttt ttcctttttt ccccctgccc ctgttctagc ttgttcttct 3600 tggtttgctt tcaacctgct tgatggatgt ctgcagagtg ctctctaaga gtccacctca 3660 gtgcctcgtg tgctcagtgg tcatgggaag gagcgaagga accatccttg gttctcccag 3720 cttggttgtg tagcaatccc tcagcattgt ttttctcagc ttcttggcaa aaattaaaac 3780 aacaacaaca acaacaacaa caacaacaaa cagaaggata aactggcttg cctgtggacc 3840 ctccccggct ctggggccag tcgagagcca ctgagggacc cagcactcag agacacaaca 3900 cacatgtgta gctgcttctg gctgagtgtg tttcctgtca ccaatggcct gtttggctgg 3960 acgatgcctc ggcttgacct tttttgaaaa gtgctggtta gttcccgccc cctggtaaac 4020 ctggggtagg tgggggttct gtcttaactc gaggggcacc tgggatccag gacgcttcta 4080 gggggctctg gctgcccgtg ttaatgaagg acagcgcttc cgcgagcacc ctgggaactg 4140 ggtcttgggt agcaaagccc tcccagagaa aagatgggca caactaaggc tttcctgagc 4200 aggaaggggg tgaagaccaa tcccttcctt tggtcctttg gtacgcaccc cctcagagct 4260 gagatggaag acatggctag ttcttttcag ccttgtggag cctgtcagtc gccatcatac 4320 ctcgagtgag gcccagctag ataatgactt gtccaagatg gcacacgtgg aaagttgatc 4380 tgcaccagaa cccggatgac tgtcaccttg aagcgtcctg ttctccttct gtgctgtccc 4440 aggaagtgtc tggcgggcgt gggcagcaca gctctacact gtacgattca ctagggcatc 4500 ctgcgagcct cactagcctt ctggttcatg cctttgacaa gcatttttgt gccccctctg 4560 cttactgtga cagtcgatga tgaatcttgc gttgccattt tctgctgtgg gtaactgcgt 4620 gcagtgtctt gccttgcttt ctcttcttac tgtcccacag cttggtttca tgttacaaac 4680 agaaaagctc gaggctccca ccccgccaca tcccaacttc atttccccct cactgtagcc 4740 catttccacc ccaccacaaa gttgccacag gttttctttg tatagaatat ttattttgaa 4800 gctctatttt aatagtattt attttagaaa gtctactatt gtaagagttc ttctgtttgt 4860 gaagaaaaaa acaagttaaa aactgaatgt actgatttag aaaatatata taaatatata 4920 ttgttaaata taaa 4934 <210> 18 <211> 2038 <212> DNA <213> Homo sapiens <400> 18 atggagagct accacaagcc tgaccagcag aagctgcagg ccttgaagga cacggccaac 60 cgcctacgta tcagctccat ccaggccacc actgcggcgg gctctggcca ccccacgtca 120 tgctgcagcg ccgcagagat catggctgtc ctctttttcc acaccatgcg ctacaagtcc 180 caggaccccc ggaatccgca caatgaccgc tttgtgctct ccaagggcca tgcagctccc 240 atcctctacg cggtctgggc tgaagctggt ttcctggccg aggcggagct gctgaacctg 300 aggaagatca gctccgactt ggacgggcac ccggtcccga aacaagcttt caccgacgtg 360 gccactggct ccctgggcca gggcctcggg gccgcttgtg ggatggccta caccggcaaa 420 tacttcgaca aggccagcta ccgagtctat tgcttgctgg gagacgggga gctgtcagag 480 ggctctgtat gggaggccat ggccttcgcc agcatctata agctggacaa cctcgtggcc 540 attctagaca tcaatcgcct gggccagagt gacccggccc ctctgcagca ccagatggac 600 atctaccaga agcggtgcga ggccttcggt tggcatgcca tcatcgtgga tggacacagc 660 gtggaggagc tgtgcaaggc ctttggccag gccaagcacc agccaacagc catcattgcc 720 aagaccttca agggccgagg gatcacgggg gtagaagata aggagtcttg gcatgggaag 780 cccctcccca aaaacatggc tgagcagatc atccaggaga tctacagcca gatccagagc 840 aaaaagaaga tcctggcaac ccctccacag gaggacgcac cctcagtgga cattgccaac 900 atccgcatgc ccagcctgcc cagctacaaa gttggggaca agatagccac ccgcaaggcc 960 tacgggcagg cactggccaa gctgggccat gccagtgacc gcatcatcgc cctggatggg 1020 gacaccaaaa attccacctt ctcggagatc ttcaaaaagg agcacccgga ccgcttcatc 1080 gagtgctaca ttgctgagca gaacatggtg agcatcgcgg tgggctgtgc cacccgcaac 1140 aggacggtgc ccttctgcag cacttttgca gccttcttca cgcgggcctt tgaccagatt 1200 cgcatggccg ccatctccga gagcaacatt aacctctgcg gctcccactg cggcgtttcc 1260 atcggggaag acgggccctc ccagatggcc ctagaagatc tggctatgtt tcggtcagtc 1320 cccacatcaa ctgtctttta cccaagtgat ggcgttgcta cagagaaggc agtggaacta 1380 gccgccaata caaagggtat ctgcttcatc cggaccagcc gcccagaaaa tgccatcatc 1440 tataacaaca atgaggactt ccaggtcgga caagccaagg tggtcctgaa gagcaaggat 1500 gaccaggtga ccgttatcgg ggctggggtg accctgcacg aggccttggc cgctgccgaa 1560 ctgctgaaga aagaaaagat caacatccgc gtgctggacc ccttcaccat caagcccctg 1620 gacagaaaac tcattctcga cagcgctcgt gccaccaagg gcaggatcct caccgtggag 1680 gaccattatt atgaaggtgg cattggtgag gctgtgtcca gtgcagtagt gggcgagcct 1740 ggcatcactg tcacccacct ggcagttaac cgggtaccaa gaagtgggaa gccggctgag 1800 ctgctgaaga tgtttggtat cgacagggat gccattgcac aagctgtgag gggcctcatc 1860 accaaggcct agggcgggta tgaagtgtgg ggcgggggtc tatacattcc tgagattctg 1920 ggaaaggtgc tcaaagatgt actgagagga ggggtaaata tatgttttga gaaaaatgaa 1980 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2038 <210> 19 <211> 946 <212> DNA <213> Homo sapiens <400> 19 ggaaacccaa gaggaaatga ctgagcccgt ctgggtcccc gcccgctcgc gctcccctgg 60 ccacaccctc cgcctggacg cagcagccac cgccgcgtcc ctctctccac gaggctgccg 120 gcttaggacc cccagctccg acatgtcgcc ctctggtcgc ctgtgtcttc tcaccatcgt 180 tggcctgatt ctccccacca gaggacagac gttgaaagat accacgtcca gttcttcagc 240 agactcaact atcatggaca ttcaggtccc gacacgagcc ccagatgcag tctacacaga 300 actccagccc acctctccaa ccccaacctg gcctgctgat gaaacaccac aaccccagac 360 ccagacccag caactggaag gaacggatgg gcctctagtg acagatccag agacacacaa 420 gagcaccaaa gcagctcatc ccactgatga caccacgacg ctctctgaga gaccatcccc 480 aagcacagac gtccagacag acccccagac cctcaagcca tctggttttc atgaggatga 540 ccccttcttc tatgatgaac acaccctccg gaaacggggg ctgttggtcg cagctgtgct 600 gttcatcaca ggcatcatca tcctcaccag tggcaagtgc aggcagctgt cccggttatg 660 ccggaatcgt tgcaggtgag tccatcagaa acaggagctg acaacctgct gggcacccga 720 agaccaagcc ccctgccagc tcaccgtgcc cagcctcctg catcccctcg aagagcctgg 780 ccagagaggg aagacacaga tgatgaagct ggagccaggg ctgccggtcc gagtctccta 840 cctcccccaa ccctgcccgc ccctgaaggc tacctggcgc cttgggggct gtccctcaag 900 ttatctcctc tgctaagaca aaaagtaaag cactgtggtc tttgcc 946 <210> 20 <211> 1246 <212> DNA <213> Homo sapiens <400> 20 gaccagccta cagccgcctg catctgtatc cagcgccagg tcccgccagt cccagctgcg 60 cgcgcccccc agtcccgcac ccgttcggcc caggctaagt tagccctcac catgccggtc 120 aaaggaggca ccaagtgcat caaatacctg ctgttcggat ttaacttcat cttctggctt 180 gccgggattg ctgtccttgc cattggacta tggctccgat tcgactctca gaccaagagc 240 atcttcgagc aagaaactaa taataataat tccagcttct acacaggagt ctatattctg 300 atcggagccg gcgccctcat gatgctggtg ggcttcctgg gctgctgcgg ggctgtgcag 360 gagtcccagt gcatgctggg actgttcttc ggcttcctct tggtgatatt cgccattgaa 420 atagctgcgg ccatctgggg atattcccac aaggatgagg tgattaagga agtccaggag 480 ttttacaagg acacctacaa caagctgaaa accaaggatg agccccagcg ggaaacgctg 540 aaagccatcc actatgcgtt gaactgctgt ggtttggctg ggggcgtgga acagtttatc 600 tcagacatct gccccaagaa ggacgtactc gaaaccttca ccgtgaagtc ctgtcctgat 660 gccatcaaag aggtcttcga caataaattc cacatcatcg gcgcagtggg catcggcatt 720 gccgtggtca tgatatttgg catgatcttc agtatgatct tgtgctgtgc tatccgcagg 780 aaccgcgaga tggtctagag tcagcttaca tccctgagca ggaaagttta cccatgaaga 840 ttggtgggat tttttgtttg tttgttttgt tttgtttgtt gtttgttgtt tgtttttttg 900 ccactaattt tagtattcat tctgcattgc tagataaaag ctgaagttac tttatgtttg 960 tcttttaatg cttcattcaa tattgacatt tgtagttgag cggggggttt ggtttgcttt 1020 ggtttatatt ttttcagttg tttgtttttg cttgttatat taagcagaaa tcctgcaatg 1080 aaaggtacta tatttgctag actctagaca agatattgta cataaaagaa tttttttgtc 1140 tttaaataga tacaaatgtc tatcaacttt aatcaagttg taacttatat tgaagacaat 1200 ttgatacata ataaaaaatt atgacaatgt caaaaaaaaa aaaaaa 1246 <210> 21 <211> 829 <212> DNA <213> Homo sapiens <400> 21 tggggagtga aagcgaaagc ccgggcgact agccgggaga ccagagatct agcgactgaa 60 gcagcatggc caagccgtgt ggggtgcgcc tgagcgggga agcccgcaaa caggtggagg 120 tcttcagaca gaatcttttc caggaggctg aggaattcct ctacagattc ttgccacaga 180 aaatcatata cctgaatcag ctcttgcaag aggactccct caatgtggct gacttgactt 240 ccctccgggc cccactggac atccccatcc cagaccctcc acccaaggat gatgagatgg 300 aaacagataa gcaggagaag aaagaagtcc ataagtgtgg atttctccct gggaatgaga 360 aagtcctgtc cctgcttgcc ctggttaagc cagaagtctg gactctcaaa gagaaatgca 420 ttctggtgat tacatggatc caacacctga tccccaagat tgaagatgga aatgattttg 480 gggtagcaat ccaggagaag gtgctggaga gggtgaatgc cgtcaagacc aaagtggaag 540 ctttccagac aaccatttcc aagtacttct cagaacgtgg ggatgctgtg gccaaggcct 600 ccaaggagac tcatgtaatg gattaccggg ccttggtgca tgagcgagat gaggcagcct 660 atggggagct cagggccatg gtgctggacc tgagggcctt ctatgctgag ctttatcata 720 tcatcagcag caacctggag aaaattgtca acccaaaggg tgaagaaaag ccatctatgt 780 actgaacccg ggactagaag gaaaataaat gatctatatg ttgtgtgga 829 <210> 22 <211> 3224 <212> DNA <213> Homo sapiens <400> 22 agcggtaaat ttgaaatggc tgacgggtcg ctgacgggcg gcggtctgga ggcagcggcc 60 atggcgccgg agcgcacggg ctgggcggtg gagcaggagc tggcgtctct ggagaaaggt 120 ttgttccaag atgaagattc atgcagtgat tgtagctacc gtgataaacc aggttctagt 180 ttacaaagtt ttatgccaga aggaaaaacc tttttcccag aaattttcca aacaaatcaa 240 cttttgttct atgagcgatt cagagcctat caagattaca ttttagctga ctgcaaggcc 300 tctgaggtac aggaattcac agctgagttc ttggagaagg tccttgagcc atctggatgg 360 cgggcagtct ggcacactaa tgtgttcaag gtgctggttg agatcacaga tgtggacttt 420 gcagccttga aggcagtggt gaggcttgct gaaccatacc tctgtgactc tcaagtgagc 480 acttttacca tggagtgcat gaaggagctc cttgatctga aggagcatcg gttgcccctg 540 caggagctgt gggtggtgtt tgatgattca ggagtgtttg accagacagc ccttgcaatt 600 gagcatgtca gatttttcta ccaaaacatt tggaggagtt gggatgaaga agaggaggat 660 gaatacgatt attttgtcag atgtgttgaa cctcgattaa gattgcatta tgacattctt 720 gaagaccgag ttccatcagg acttattgtt gactaccaca atctgttgtc tcaatgtgag 780 gagagttaca ggaaattttt aaatctgaga agcagtttgt caaattgtaa ctctgattcc 840 gagcaggaaa atatctccat ggtggaaggg ttaaaattgt attcggagat ggaacagttg 900 aaacaaaagc tgaaactcat tgagaatcct ttgttgaggt atgtgtttgg ttatcagaag 960 aattctaaca tccaagcaaa gggtgtccgt tccagcggtc agaagatcac tcatgtggtc 1020 tcctccacca tgatggctgg tctcctgcgg tccctgctta cggacaggct ttgccaggag 1080 cctggtgagg aagaaagaga aattcagttc catagtgatc cattgtctgc tataaatgcc 1140 tgcttcgaag gtgacactgt tattgtttgt cctggccatt atgtggtaca tggcactttc 1200 tccattgctg actccattga gttggaagga tatggcctac cagatgacat tgtgatagaa 1260 aagaggggca aaggcgacac ttttgtggac tgcactggtg ctgatattaa aatctcaggc 1320 ataaaatttg ttcagcatga tgctgtagag ggaatcttaa ttgttcaccg tggtaagact 1380 acgctggaaa actgtgtgct gcagtgtgag acgaccggag tcacagtgcg gacatcagca 1440 gagtttctaa tgaagaactc ggatttatat ggcgccaagg gtgctggtat agaaatctac 1500 cctgggagtc agtgcaccct gagtgacaat gggatccatc actgcaagga agggatcctc 1560 attaaggact tcttagatga acattatgac attcccaaga tatccatggt gaataatata 1620 atacataata atgaaggtta tggtgttgtc ttggtgaaac ctacaatctt ctctgacctg 1680 caagaaagtg ctgaagatgg aactgaagaa aataaagcgc ttaaaattca gacaagtgga 1740 gagccagatg tggctgaaag agtggatcta gaagagctga ttgagtgtgc aactggtaaa 1800 atggagcttt gtgcaagaac tgacccttct gagcaagtcg agggaaattg tgaaattgta 1860 aatgaactaa ttgctgcctc cacacagaaa ggccagataa agaagaaaag gttgagtgaa 1920 ctggggatca cgcaagctga tgacaactta atgtcacagg agatgtttgt tgggattgtg 1980 gggaaccagt tcaagtggaa tgggaaaggt agttttggca catttctttt ctgactacag 2040 tgatgtaagt agatagcaaa atactggatt ttgcacatgc tgccctaaga atcactgctg 2100 ccattgtagt ttgctgtatt gtctgtattt tatatttgat tatttgggct tgagtgaaag 2160 gtagatttat ttccatttgc aggtgttgca cataaaacac tccctcttta taagaaaaat 2220 cataaatgca tataaaatag aaaatatttg gagattgctt atctgaaagt cttgctttct 2280 tatacacatg gttctctcat attaagcctg gtggtaactt tttagtgtaa ttacctttag 2340 cacttcaaag acgaggaagt aaggaaggga atgcaagact agtgcataaa aatgcaatag 2400 gtgtcatatg tacagcattc ttcttagagt tgccttttca tcccaattac agtgagtctg 2460 atttccatcc tgtatttgca taatacttgt cttaaaataa aagcttttat gattgggaat 2520 ttatctgcct aatcagactt attattgaga cgtcaatggg acgcattttt ctgttgagct 2580 atgcagtcgt caaaacagcg atagacagca taggaggttt gaagcagaaa tgaaatgtgt 2640 tattcagagc caatgttgta catagagcat tttcactatt gctgaatggg aatgattaaa 2700 aacaaggtat ttttcgggcc aggcggtggc tcacgcttgt aatcgcagca ctttgggagg 2760 ctgaggcagg aggatcactt gagcccagga gttcaagact agcctaggca acatagtgag 2820 accctgtctc tactaaaaat aaatttaaaa aaaattagct gagtgtggtg gtgcatgcat 2880 gtagttccag ctactcagga ggctgaggct agaggatcct tgagcccagg aggttgaggc 2940 tgcagtgagg tgtgattgcg ccactgcatt ccagcttggg cgacagagcg agacccagtc 3000 tcaaaaaaaa aaaaagtatt tttctcttac cgttacagta ttctgattat attactgaca 3060 cagtcaaaat gattaactgt acaacctgta tctgctgggt gttcttgtta tcatattgta 3120 aaacagcttt aaaaatattt atattttaaa aactgtatgt gacattaata tgcctaatga 3180 ttaaaattat agtgatgaaa taacaaagaa aaaaaaaaaa aaaa 3224 <210> 23 <211> 5145 <212> DNA <213> Homo sapiens <400> 23 cgggcccctc gccactaccg ccgccgccgc cgccgtgagt cccgcggagc cgcgcgcgcc 60 cccggctggg ccgagccgct ggccgacgag cggagcctca ggagccggcg gggacgccat 120 gcgagccagc gtctcccttc tctcctggac agaaggccgt gtcctgggac ttctctgatg 180 gcgagaggct gcggctgtac caggaagaaa catattgccg agtggatgcc gccgcgcagc 240 gtgtttgctt gaggcagaag cttcagcatc tgctgggata actggaggaa gaaatatgaa 300 gccttagcgg ctttacccgg gaagcgagtt tcgagatggc ggctcagcgg atccgagcgg 360 ccaactccaa tggcctccct cgctgcaagt cagaggggac cctgattgac ctgagcgaag 420 ggttttcaga gacgagcttt aatgacatca aagtgccttc tcccagtgcc ttgctcgtag 480 acaaccccac acctttcgga aatgcaaagg aagtgattgc gatcaaggac tattgcccca 540 ccaacttcac cacactgaag ttctccaagg gcgaccatct ctacgtcttg gacacatctg 600 gcggtgagtg gtggtacgca cacaacacca ccgaaatggg ctacatcccc tcctcctatg 660 tgcagccctt gaactaccgg aactcaacac tgagtgacag cggtatgatt gataatcttc 720 cagacagccc agacgaggta gccaaggagc tggagctgct cgggggatgg acagatgaca 780 aaaaagtacc aggcagaatg tacagtaata accctttctg gaatggggtc cagaccaatc 840 catttctgaa tgggaacgtg cccgtcatgc ccagcctgga tgagctgaat cccaaaagta 900 ctgtggattt gctccttttt gacgcaggta catcctcctt caccgaatcc agctcagcca 960 ccacgaatag cactggcaac atcttcgatg agcttccagt cacaaacgga ctccacgcag 1020 agccgccggt caggcgggac aaccccttct tcagaagcaa gcgctcctac agtctctcgg 1080 aactctccgt cctccaagcc aagtccgatg ctcccacatc gtcgagtttc ttcaccggct 1140 tgaaatcacc tgcccccgag caatttcaga gccgggagga ttttcgaact gcctggctaa 1200 accacaggaa gctggcccgg tcttgccacg acctggactt gcttggccaa agccctggtt 1260 ggggccagac ccaagccgtg gagacaaaca tcgtgtgcaa gctggatagc tccgggggtg 1320 ctgtccagct tcctgacacc agcatcagca tccacgtgcc cgagggccac gtcgcccctg 1380 gggagaccca gcagatctcc atgaaagccc tgctggaccc cccgctggag ctcaacagtg 1440 acaggtcctg cagcatcagc cctgtgctgg aggtcaagct gagcaacctg gaggtgaaaa 1500 cctctatcat cttggagatg aaagtgtcag ccgagataaa aaatgacctt tttagcaaaa 1560 gcacagtggg cctccagtgc ctgaggagcg actcgaagga agggccatat gtctccgtcc 1620 cgctcaactg cagctgtggg gacacggtcc aggcacagct gcacaacctg gagccctgta 1680 tgtacgtggc tgtcgtggcc catggcccaa gcatcctcta cccttccacc gtgtgggact 1740 tcatcaataa aaaagtcaca gtgggtctct acggccctaa acacatccac ccatccttca 1800 agacggtagt gaccattttt gggcatgact gtgccccaaa gacgctcctg gtcagcgagg 1860 tcacacgcca ggcacccaac cctgccccgg tggccctgca gctgtggggg aagcaccagt 1920 tcgttttgtc caggccccag gatctcaagg tctgtatgtt ttccaatatg acgaattacg 1980 aggtcaaagc cagcgagcag gccaaagtgg tgcgaggatt ccagctgaag ctgggcaagg 2040 tgagccgcct gatcttcccc atcacctccc agaaccccaa cgagctctct gacttcacgc 2100 tgcgggttca ggtgaaggac gaccaggagg ccatcctcac ccagttttgt gtccagactc 2160 ctcagccacc ccctaaaagt gccatcaagc cttccgggca aaggaggttt ctcaagaaga 2220 acgaagtcgg gaaaatcatc ctgtccccgt ttgccaccac tacaaagtac ccgactttcc 2280 aggaccgccc ggtgtccagc ctcaagtttg gtaagttgct caagactgtg gtgcggcaga 2340 acaagaacca ctacctgctg gagtacaaga agggcgacgg gatcgccctg ctcagcgagg 2400 agcgggtcag gctccggggc cagctgtgga ccaaggagtg gtacatcggc tactaccagg 2460 gcagggtggg cctcgtgcac accaagaacg tgctggtggt cggcagggcc cggcccagcc 2520 tgtgctcggg ccccgagctg agcacctcgg tgctgctgga gcagatcctg cggccctgca 2580 aattcctcac gtacatctat gcctccgtga ggaccctgct catggagaac atcagcagct 2640 ggcgctcctt cgctgacgcc ctgggctacg tgaacctgcc gctcaccttt ttctgccggg 2700 cagagctgga tagtgagccc gagcgggtgg cgtccgtcct agaaaagctg aaggaggact 2760 gtaacaacac tgagaacaaa gaacggaagt ccttccagaa ggagcttgtg atggccctac 2820 tgaagatgga ctgccagggc ctggtggtca gactcatcca ggactttgtg ctcctgacca 2880 cggctgtaga ggtggcccag cgctggcggg agctggctga gaagctggcc aaggtctcca 2940 agcagcagat ggacgcctac gagtctcccc accgggacag gaacggggtt gtggacagcg 3000 aggccatgtg gaagcctgcg tatgacttct tactcacctg gagccatcag atcggggaca 3060 gctaccggga tgtcatccag gagctgcacc tgggcctgga caagatgaaa aaccccatca 3120 ccaagcgctg gaagcacctc actgggactc tgatcttggt gaactccctg gacgttctga 3180 gagcagccgc cttcagccct gcggaccagg acgacttcgt gatttgaatg ggtcccctcc 3240 cctcctgctg ctctggagtg caagccctct tctgccctgc gtgccctgct gtcaccgcgg 3300 agctgaagag ggaggaaggg gcggctgctc agacagattt agggcccgcc agctaggcta 3360 cacccatcat gcgccgccct cctccatcga gggagaggcc tgaagggact gcctactgca 3420 gctcgttgcc aatcacatag ctttctattt gttaagtata aatttaaatt taaaatcact 3480 tttttaacga atggggggaa gggatctatg agaaaggtgg tatctaattt ttttatggac 3540 cataaaggtt taaaagaaaa taggggcaca ggctgttgag gtttttatgt tgttatagac 3600 ctttttaaat tatgttagag atgtatatag gtatttaaag gtcactggga gcgtttctga 3660 ttcccggcca cactttgcat ttcaacactc agcccggaaa gatgctcgtt cggttgttgg 3720 acctctttca ctccctgcgt gtaagaaggt gaatcacgtg ggaaaaagtg gcttttcagt 3780 aaacgggtac agctcattct ttctgagaag gccccaggtc ctgctccctc ctcggatttg 3840 attgtcttcc gtgctttgcc tcactcgtag taaatgacca tccatagaat atgtgaatct 3900 ttggtgagct tcagtgggca gagtgaagtc ccgcattagc atttaggtgc cctgagctgt 3960 ttctgccaat agattagaaa gcagccatga gttgacagtc tttagggccc ctgccagtgt 4020 gcaattagtc attgacaaga acaatgccat ttgagagtga ggtggtccct gctgctacga 4080 ggccattgta ctgttttttc cttgaggtca aagcagtgct tcccatagag tttgctgcct 4140 cttctgtgga caggaagaaa acttcatgac cgaatcagag ccttggtggc cactgactct 4200 cgtgcttatt gcagatgctg tggttggcct cacaagcaac gccttatgct gatgtgcaga 4260 ggtgccagct gccatttgcc aaactctgca tttcatttca tctaaggctt aacccctctt 4320 ccttcctggt gtacctgtgt ctcctcggaa ggaagtcata gtttagatga aaccattttt 4380 tgtacaatgt aaagatcatc tgagcaagat gagcattttg taaaaatgaa aatgtgactc 4440 acataaaatc aggaacttga cacagtgttg cattaataac tttagggtgc agacatgctg 4500 tgtgaatctc acaatgcgtc gtagatgtcg cgtgttggaa gggagcagga ggaaggactg 4560 atactggcaa atcagtagag tgaggtgatc cttagcaacg tgccaggaca cttcctgtgt 4620 gcctgcagtt gtcagggacc atttgggatc ccgaatctca ttctctaaaa ctgctttctt 4680 gaaacatgtt acttccttag tataatcaat gtatactccc ttactggcct gaaacgttgt 4740 atagctactt attcagatac tgaagaccaa cggactgaaa aaaagaacaa acattagcta 4800 ttttatgctg caagaaccag gacacacaat tcgccaatca tcccaccata taaccttcga 4860 ttgtgcttct caactccacc ccataatttc tcccagagac catctatcac cttttcccca 4920 aagaagaaac aaaaccagtt gcaccttaaa ccatggatat tttttcctca ggggctttaa 4980 atagtttcct atgcaacgtg tcttgtagca caaataaaat tctacaaaag ttgcagtaaa 5040 ttttatttgg atattttaac ctgttaagtg tgtgtgtgtt ttctgtaccc aaccagactt 5100 taaataaaac aaacatgaaa cctaaaaaaa aaaaaaaaaa aaaaa 5145 <210> 24 <211> 2749 <212> DNA <213> Homo sapiens <400> 24 gcacaaacaa gctggagcag cccagaggac aagaattttg ggcagatttg aatgccatga 60 acgtgtatga aacaactgaa tttgaccaac tacgaaggct gtccacacca ccctctagca 120 atgtcaactc tatttaccac acagtctgga aattcttctg tagggaccac tttggatgga 180 gagagtatcc cgagtctgtc attcgattga ttgaagaagc caactctcgg ggtctgaaag 240 aggttcgatt tatgatgtgg aataaccact acatcctcca caattcattc ttcaggagag 300 agataaaaag gagacccctc ttccgctcct gttttatact gcttccatat ttacagacac 360 ttggtggggt tcccacacaa gctcctccac ctcttgaagc aacttcatca tcacaaatta 420 tctgcccaga tggggtcact tcagcaaact tttaccctga aacttgggtt tatatgcatc 480 catctcagga cttcatccaa gtccctgttt ctgcagagga taaaagttat cggatcattt 540 acaatctttt tcataagact gtgcctgagt ttaaatacag aattttgcag atattgagag 600 tccaaaacca gtttctttgg gagaaatata aaaggaaaaa ggaatatatg aacaggaaaa 660 tgtttggccg tgacaggata ataaatgaga gacatttatt tcatggaaca tcccaggatg 720 tggtagatgg aatctgcaaa cacaactttg accctcgagt ctgtggaaag catgctacaa 780 tgtttggaca aggcagttat tttgcaaaga aggcaagcta ctctcataac ttttctaaga 840 agtcctccaa aggagtccac ttcatgtttc tggccaaagt gctgacgggc agatacacaa 900 tgggcagtca tggcatgaga aggcccccgc cagtcaatcc tggcagtgtc accagtgacc 960 tttatgactc ttgtgtggat aatttctttg agcctcagat ttttgtcatt tttaatgatg 1020 accagagtta cccttatttt gttatccaat atgaagaagt cagtaacact gtttccattt 1080 gaaaaatctt ggtactgcta aattatttga tatgaactca atccagcatt tgtagcaggt 1140 tttgaatggg tgggactggg tggggaacag cattggacat taatagggca cttttcagac 1200 ccatttttta aagtgctaga aaatgctttt ttttaaaaaa aaatacaagt tttaaaatga 1260 ccacttactc tttaattatt tactaattgc tagtgtactc agtgtggaaa agactacaga 1320 ttacacactc ttttcattca cacttgtaca tatagacagc aatgttatta ggagcattaa 1380 attaaaaaac tgaacagcct aatttaaatg tggcttgggc ctggtagaag tttgaccaaa 1440 tggaatggag gctgtgagca atgtgaggat tctatttatt tatttacgtt tgataaaact 1500 tactggaact agtactacca tgcgtattcc ctgtccaaag catcactgct ttggtatagt 1560 ataagttcat gaaattctgg tgggtagaaa gaaattttta tttctatcag cagtactaaa 1620 atgtatcagc caaccagaga acatcagtga ctttaacttc tgcagagttt gccccagaat 1680 tcagagttct atttagagga agttaaaaca acaacaaaaa acaaccattt gaaaaatttt 1740 tgtcaccagc aaaacttttc actaattagt gatatgaaat gtgatttttg tgttgttaaa 1800 cttcagcttt ggaaaactca gtctctttca ttatcatcca ttccaatttg aaggagttgg 1860 gcagctaatt tggttaaagg cagtcttgag ggttagaagt attacttcct tttcgggttc 1920 cagacctagc ttgtgactga aagttttaga aaaaggaagt acatctatag ccgaattgat 1980 aaggttatta ctgtgttttg cacaaagtat attagcaaaa gtatttgctg gaattattgg 2040 tagatggcag tcccactcct acacctgctt tgtcagatac agctgggttc cctggctgac 2100 tctgtacctt acttacacta cttacttaat agaaacacaa acttggaaat tgtgccagtg 2160 gtccagctgg agcacaacgt ttggtgaata tgctgtttcc tcagttcaga gaggtagcaa 2220 ctaggtaaac tccttataaa aagcaaatac ctggatttac aaaagtgaaa gtagttgttc 2280 acaaaagaat tcgccatgga attctttcag ttaccaagct ctcctggtaa tgtttgtggt 2340 tatatcattt acacaaaact tttcaggaac ttctgtgttg tttaagcaag atgtatctgt 2400 actgatgtct cagtgaatca gtctgtttat taagcactta tcagggcttc cacacactta 2460 tttattttgc cctagttaat cctgttgttt gctgccattg gcatgaaatg gccaactgtg 2520 gctgttacag ttctttcatt caattataac ttgtaaacca gtgactccta atctttttca 2580 agttaagaca ccttaccatt gcttatttgg ttttatgaga cttgttcctt tttttctccc 2640 taaggaaaaa gaaagcttta tgacatattt atttttttaa taaaactaag caaaaataaa 2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2749 <210> 25 <211> 2358 <212> DNA <213> Homo sapiens <400> 25 gagtcctcag ctctccctac tccacgctgc ctagacatac acagctgcag ggtctggctg 60 aacaatcaag gggccgccag agaaaggcca tctacggtgc gcagtgtatc tggagttgct 120 gggcccaaga tagctctgtg gagttatcac tagagatgcc tctggattaa ctaagaggtg 180 tgcctgggtg tgggtgagga gtcagaacct ttgagagctt tgagatgaca gtttctatgg 240 ggcgggaaga aggaggtgca tttctacaaa cacttccctg aaatccttgg gaaaaacaga 300 ggcatggccg tggccaactc tgtgggaact ggcgcctctg tccttgttgg cactgttctc 360 agtccgatga cttgcattgt gttttctcca atttttgctg ggattttaat gttcagcatg 420 gtgggaggaa cccttgattc cttttgtttg agtatagaaa gtaaattttt gaggtcatga 480 tgtgaacggc catgttattg tgattatctt cagctcagga taggctgaga tgctttgtgg 540 agtgttccat gaagcccgag tcggaatctc tgactgtcgt gtacagccat aaggagactg 600 gtttgaatta ctgtggcgag acagggcgtg cctgtcagaa atctgagatg tttgtacgct 660 ctgagatgtt gaacctttct ggtgggcagc accgacaccc aggggtggac ccccgaggat 720 gaatgcctct aggcctccgc aacatattca agaatgaatg ggagacgcta gagtaaaatg 780 ggggcagaga ggatatcagg gagcaagatg caaactgtgt gcatccactc tcgtaaacaa 840 gtagctggtc acaaccagaa aggttcatct ctcctaagca aacagcgact ctttcagagg 900 aagtttccct ctttcaatcg tggccttatt ttcaactccg gtgccttctc gtgatgttaa 960 tcatttcctt ttttccccac actaagctct cttttctatc tttctctctc tttccaatct 1020 tacgccatgg ccatcagttc atttcagcct tccagtgcta cacccacttc ttggctgaca 1080 cacttctgct ctaaggtgac tggttttctt gccaattttc aaagagtggt actaaccccc 1140 aacccgcttt ccgcaccccg tcctctccgc cagcagtact ggttgcacta actgtgagtg 1200 tcttgcatac tgatggactc atttggtggc atggttggct aacagcatgg cggggggtgt 1260 tcagcttgag acccatgcct gtgttcattt cccatggagc tggcagcctg gtctacccca 1320 agtgcatgcc ccgcctctcc tctctccctt gggtctgcct gcgtgcatgc ttctccagtt 1380 gcgtctgcga agctacctac tttcttggga gggtcgacct tgatcatgaa acaataccat 1440 gagggggcct ctgtcacctt tgaaaagaac actttttgag cagcctcaaa aagctcatac 1500 ataccagcgc cttcttaaat tggctctaat gtaaagattg ttaatgtcat ttatcaaaac 1560 cataggtgat tatttggagg gatttaaaaa acttaattac tctcaggcct catcccaagc 1620 ttgacacatg ctctgtaggt tgaacacata atcacaaata ttctagcaaa tgctgccttg 1680 gttgcagcct gcactgtaga cccaagggtt ttgctgtggc tcttcttatc tcccttggct 1740 cataaagccc cagatgatgc cagagcttca attagagcca tcatcatccc aggcagggat 1800 atctttgaga aatgactcag ttcagcccca ggcccctgtg actctgctta aagcacacat 1860 ttctgctgac tcttgtacct ggggcagcag gataatcacc aacacactct taacgagaaa 1920 caacacacca agcacagtgg agctgtccta ggcaacactc gcggtctcag gctgcggtgg 1980 gcgtctgtcc tgcatgtggc ccagaccacc ctgacccccg ggcctgcctg cctggccctg 2040 catgctgcac gctcactgta tttgtgcaga tcctggccag tacaaagtcg ttgctcttgt 2100 cttatcttct cttacagagt ctccctccct ttatagaatg tcaaccaaag agtgccctcc 2160 tcccctctca gcctcctctt tagctagcct ccccatctca tcacaacgca tgtctgtgac 2220 ctttggtaat catttacagt gccacacgga accctgtatt ttgcacacag caaaacaaac 2280 aatgtttagc tttatttatg gtatttgatg ctgtaaatgg aaataaatat tgttctttat 2340 aaaaaaaaaa aaaaaaaa 2358 <210> 26 <211> 2944 <212> PRT <213> Homo sapiens <400> 26 Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 1 5 10 15 Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 20 25 30 Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 35 40 45 Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 50 55 60 Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 65 70 75 80 Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 85 90 95 Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 100 105 110 Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 115 120 125 His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 130 135 140 Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 145 150 155 160 Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 165 170 175 Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 180 185 190 Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 195 200 205 Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 210 215 220 Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 225 230 235 240 Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 245 250 255 Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 260 265 270 Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 275 280 285 Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 290 295 300 Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 305 310 315 320 Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 325 330 335 Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 340 345 350 Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 355 360 365 Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 370 375 380 Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 385 390 395 400 Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 405 410 415 Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 420 425 430 Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 435 440 445 Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 450 455 460 Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 465 470 475 480 Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 485 490 495 Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 500 505 510 Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 515 520 525 Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 530 535 540 Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 545 550 555 560 Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 565 570 575 Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 580 585 590 Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 595 600 605 Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 610 615 620 Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 625 630 635 640 Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 645 650 655 Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 660 665 670 Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 675 680 685 Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 690 695 700 Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 705 710 715 720 Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 725 730 735 Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 740 745 750 Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 755 760 765 Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 770 775 780 Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 785 790 795 800 Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 805 810 815 Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 820 825 830 Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 835 840 845 Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 850 855 860 Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 865 870 875 880 His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 885 890 895 Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 900 905 910 Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 915 920 925 Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 930 935 940 Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 945 950 955 960 Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 965 970 975 Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 980 985 990 Arg Gly Pro Gly Gln Glu Val Pro Gly Ser Pro Gln Thr Leu Pro Gly 995 1000 1005 Ile Ser Ser Ser Gln Arg Val Thr Gly Leu Glu Pro Gly Val Ser Tyr 1010 1015 1020 Ile Phe Ser Leu Thr Pro Val Leu Asp Gly Val Arg Gly Pro Glu Ala 1025 1030 1035 1040 Ser Val Thr Gln Thr Pro Val Cys Pro Arg Gly Leu Ala Asp Val Val 1045 1050 1055 Phe Leu Pro His Ala Thr Gln Asp Asn Ala His Arg Ala Glu Ala Thr 1060 1065 1070 Arg Arg Val Leu Glu Arg Leu Val Leu Ala Leu Gly Pro Leu Gly Pro 1075 1080 1085 Gln Ala Val Gln Val Gly Leu Leu Ser Tyr Ser His Arg Pro Ser Pro 1090 1095 1100 Leu Phe Pro Leu Asn Gly Ser His Asp Leu Gly Ile Ile Leu Gln Arg 1105 1110 1115 1120 Ile Arg Asp Met Pro Tyr Met Asp Pro Ser Gly Asn Asn Leu Gly Thr 1125 1130 1135 Ala Val Val Thr Ala His Arg Tyr Met Leu Ala Pro Asp Ala Pro Gly 1140 1145 1150 Arg Arg Gln His Val Pro Gly Val Met Val Leu Leu Val Asp Glu Pro 1155 1160 1165 Leu Arg Gly Asp Ile Phe Ser Pro Ile Arg Glu Ala Gln Ala Ser Gly 1170 1175 1180 Leu Asn Val Val Met Leu Gly Met Ala Gly Ala Asp Pro Glu Gln Leu 1185 1190 1195 1200 Arg Arg Leu Ala Pro Gly Met Asp Ser Val Gln Thr Phe Phe Ala Val 1205 1210 1215 Asp Asp Gly Pro Ser Leu Asp Gln Ala Val Ser Gly Leu Ala Thr Ala 1220 1225 1230 Leu Cys Gln Ala Ser Phe Thr Thr Gln Pro Arg Pro Glu Pro Cys Pro 1235 1240 1245 Val Tyr Cys Pro Lys Gly Gln Lys Gly Glu Pro Gly Glu Met Gly Leu 1250 1255 1260 Arg Gly Gln Val Gly Pro Pro Gly Asp Pro Gly Leu Pro Gly Arg Thr 1265 1270 1275 1280 Gly Ala Pro Gly Pro Gln Gly Pro Pro Gly Ser Ala Thr Ala Lys Gly 1285 1290 1295 Glu Arg Gly Phe Pro Gly Ala Asp Gly Arg Pro Gly Ser Pro Gly Arg 1300 1305 1310 Ala Gly Asn Pro Gly Thr Pro Gly Ala Pro Gly Leu Lys Gly Ser Pro 1315 1320 1325 Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Glu Arg Gly Pro Arg Gly 1330 1335 1340 Pro Lys Gly Glu Pro Gly Ala Pro Gly Gln Val Ile Gly Gly Glu Gly 1345 1350 1355 1360 Pro Gly Leu Pro Gly Arg Lys Gly Asp Pro Gly Pro Ser Gly Pro Pro 1365 1370 1375 Gly Pro Arg Gly Pro Leu Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly 1380 1385 1390 Leu Pro Gly Thr Ala Met Lys Gly Asp Lys Gly Asp Arg Gly Glu Arg 1395 1400 1405 Gly Pro Pro Gly Pro Gly Glu Gly Gly Ile Ala Pro Gly Glu Pro Gly 1410 1415 1420 Leu Pro Gly Leu Pro Gly Ser Pro Gly Pro Gln Gly Pro Val Gly Pro 1425 1430 1435 1440 Pro Gly Lys Lys Gly Glu Lys Gly Asp Ser Glu Asp Gly Ala Pro Gly 1445 1450 1455 Leu Pro Gly Gln Pro Gly Ser Pro Gly Glu Gln Gly Pro Arg Gly Pro 1460 1465 1470 Pro Gly Ala Ile Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Leu 1475 1480 1485 Gly Glu Ala Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Pro Ala Gly 1490 1495 1500 Ser Arg Gly Leu Pro Gly Val Ala Gly Arg Pro Gly Ala Lys Gly Pro 1505 1510 1515 1520 Glu Gly Pro Pro Gly Pro Thr Gly Arg Gln Gly Glu Lys Gly Glu Pro 1525 1530 1535 Gly Arg Pro Gly Asp Pro Ala Val Val Gly Pro Ala Val Ala Gly Pro 1540 1545 1550 Lys Gly Glu Lys Gly Asp Val Gly Pro Ala Gly Pro Arg Gly Ala Thr 1555 1560 1565 Gly Val Gln Gly Glu Arg Gly Pro Pro Gly Leu Val Leu Pro Gly Asp 1570 1575 1580 Pro Gly Pro Lys Gly Asp Pro Gly Asp Arg Gly Pro Ile Gly Leu Thr 1585 1590 1595 1600 Gly Arg Ala Gly Pro Pro Gly Asp Ser Gly Pro Pro Gly Glu Lys Gly 1605 1610 1615 Asp Pro Gly Arg Pro Gly Pro Pro Gly Pro Val Gly Pro Arg Gly Arg 1620 1625 1630 Asp Gly Glu Val Gly Glu Lys Gly Asp Glu Gly Pro Pro Gly Asp Pro 1635 1640 1645 Gly Leu Pro Gly Lys Ala Gly Glu Arg Gly Leu Arg Gly Ala Pro Gly 1650 1655 1660 Val Arg Gly Pro Val Gly Glu Lys Gly Asp Gln Gly Asp Pro Gly Glu 1665 1670 1675 1680 Asp Gly Arg Asn Gly Ser Pro Gly Ser Ser Gly Pro Lys Gly Asp Arg 1685 1690 1695 Gly Glu Pro Gly Pro Pro Gly Pro Pro Gly Arg Leu Val Asp Thr Gly 1700 1705 1710 Pro Gly Ala Arg Glu Lys Gly Glu Pro Gly Asp Arg Gly Gln Glu Gly 1715 1720 1725 Pro Arg Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly Ala Pro Gly Glu 1730 1735 1740 Arg Gly Ile Glu Gly Phe Arg Gly Pro Pro Gly Pro Gln Gly Asp Pro 1745 1750 1755 1760 Gly Val Arg Gly Pro Ala Gly Glu Lys Gly Asp Arg Gly Pro Pro Gly 1765 1770 1775 Leu Asp Gly Arg Ser Gly Leu Asp Gly Lys Pro Gly Ala Ala Gly Pro 1780 1785 1790 Ser Gly Pro Asn Gly Ala Ala Gly Lys Ala Gly Asp Pro Gly Arg Asp 1795 1800 1805 Gly Leu Pro Gly Leu Arg Gly Glu Gln Gly Leu Pro Gly Pro Ser Gly 1810 1815 1820 Pro Pro Gly Leu Pro Gly Lys Pro Gly Glu Asp Gly Lys Pro Gly Leu 1825 1830 1835 1840 Asn Gly Lys Asn Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Arg Lys 1845 1850 1855 Gly Glu Lys Gly Asp Ser Gly Ala Ser Gly Arg Glu Gly Arg Asp Gly 1860 1865 1870 Pro Lys Gly Glu Arg Gly Ala Pro Gly Ile Leu Gly Pro Gln Gly Pro 1875 1880 1885 Pro Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Gln Gly Phe Pro Gly 1890 1895 1900 Val Pro Gly Gly Thr Gly Pro Lys Gly Asp Arg Gly Glu Thr Gly Ser 1905 1910 1915 1920 Lys Gly Glu Gln Gly Leu Pro Gly Glu Arg Gly Leu Arg Gly Glu Pro 1925 1930 1935 Gly Ser Val Pro Asn Val Asp Arg Leu Leu Glu Thr Ala Gly Ile Lys 1940 1945 1950 Ala Ser Ala Leu Arg Glu Ile Val Glu Thr Trp Asp Glu Ser Ser Gly 1955 1960 1965 Ser Phe Leu Pro Val Pro Glu Arg Arg Arg Gly Pro Lys Gly Asp Ser 1970 1975 1980 Gly Glu Gln Gly Pro Pro Gly Lys Glu Gly Pro Ile Gly Phe Pro Gly 1985 1990 1995 2000 Glu Arg Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Pro Gln Gly Pro 2005 2010 2015 Pro Gly Leu Ala Leu Gly Glu Arg Gly Pro Pro Gly Pro Ser Gly Leu 2020 2025 2030 Ala Gly Glu Pro Gly Lys Pro Gly Ile Pro Gly Leu Pro Gly Arg Ala 2035 2040 2045 Gly Gly Val Gly Glu Ala Gly Arg Pro Gly Glu Arg Gly Glu Arg Gly 2050 2055 2060 Glu Lys Gly Glu Arg Gly Glu Gln Gly Arg Asp Gly Pro Pro Gly Leu 2065 2070 2075 2080 Pro Gly Thr Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Val Ser Val 2085 2090 2095 Asp Glu Pro Gly Pro Gly Leu Ser Gly Glu Gln Gly Pro Pro Gly Leu 2100 2105 2110 Lys Gly Ala Lys Gly Glu Pro Gly Ser Asn Gly Asp Gln Gly Pro Lys 2115 2120 2125 Gly Asp Arg Gly Val Pro Gly Ile Lys Gly Asp Arg Gly Glu Pro Gly 2130 2135 2140 Pro Arg Gly Gln Asp Gly Asn Pro Gly Leu Pro Gly Glu Arg Gly Met 2145 2150 2155 2160 Ala Gly Pro Glu Gly Lys Pro Gly Leu Gln Gly Pro Arg Gly Pro Pro 2165 2170 2175 Gly Pro Val Gly Gly His Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly 2180 2185 2190 Leu Ala Gly Pro Ala Gly Pro Gln Gly Pro Ser Gly Leu Lys Gly Glu 2195 2200 2205 Pro Gly Glu Thr Gly Pro Pro Gly Arg Gly Leu Thr Gly Pro Thr Gly 2210 2215 2220 Ala Val Gly Leu Pro Gly Pro Pro Gly Pro Ser Gly Leu Val Gly Pro 2225 2230 2235 2240 Gln Gly Ser Pro Gly Leu Pro Gly Gln Val Gly Glu Thr Gly Lys Pro 2245 2250 2255 Gly Ala Pro Gly Arg Asp Gly Ala Ser Gly Lys Asp Gly Asp Arg Gly 2260 2265 2270 Ser Pro Gly Val Pro Gly Ser Pro Gly Leu Pro Gly Pro Val Gly Pro 2275 2280 2285 Lys Gly Glu Pro Gly Pro Thr Gly Ala Pro Gly Gln Ala Val Val Gly 2290 2295 2300 Leu Pro Gly Ala Lys Gly Glu Lys Gly Ala Pro Gly Gly Leu Ala Gly 2305 2310 2315 2320 Asp Leu Val Gly Glu Pro Gly Ala Lys Gly Asp Arg Gly Leu Pro Gly 2325 2330 2335 Pro Arg Gly Glu Lys Gly Glu Ala Gly Arg Ala Gly Glu Pro Gly Asp 2340 2345 2350 Pro Gly Glu Asp Gly Gln Lys Gly Ala Pro Gly Pro Lys Gly Phe Lys 2355 2360 2365 Gly Asp Pro Gly Val Gly Val Pro Gly Ser Pro Gly Pro Pro Gly Pro 2370 2375 2380 Pro Gly Val Lys Gly Asp Leu Gly Leu Pro Gly Leu Pro Gly Ala Pro 2385 2390 2395 2400 Gly Val Val Gly Phe Pro Gly Gln Thr Gly Pro Arg Gly Glu Met Gly 2405 2410 2415 Gln Pro Gly Pro Ser Gly Glu Arg Gly Leu Ala Gly Pro Pro Gly Arg 2420 2425 2430 Glu Gly Ile Pro Gly Pro Leu Gly Pro Pro Gly Pro Pro Gly Ser Val 2435 2440 2445 Gly Pro Pro Gly Ala Ser Gly Leu Lys Gly Asp Lys Gly Asp Pro Gly 2450 2455 2460 Val Gly Leu Pro Gly Pro Arg Gly Glu Arg Gly Glu Pro Gly Ile Arg 2465 2470 2475 2480 Gly Glu Asp Gly Arg Pro Gly Gln Glu Gly Pro Arg Gly Leu Thr Gly 2485 2490 2495 Pro Pro Gly Ser Arg Gly Glu Arg Gly Glu Lys Gly Asp Val Gly Ser 2500 2505 2510 Ala Gly Leu Lys Gly Asp Lys Gly Asp Ser Ala Val Ile Leu Gly Pro 2515 2520 2525 Pro Gly Pro Arg Gly Ala Lys Gly Asp Met Gly Glu Arg Gly Pro Arg 2530 2535 2540 Gly Leu Asp Gly Asp Lys Gly Pro Arg Gly Asp Asn Gly Asp Pro Gly 2545 2550 2555 2560 Asp Lys Gly Ser Lys Gly Glu Pro Gly Asp Lys Gly Ser Ala Gly Leu 2565 2570 2575 Pro Gly Leu Arg Gly Leu Leu Gly Pro Gln Gly Gln Pro Gly Ala Ala 2580 2585 2590 Gly Ile Pro Gly Asp Pro Gly Ser Pro Gly Lys Asp Gly Val Pro Gly 2595 2600 2605 Ile Arg Gly Glu Lys Gly Asp Val Gly Phe Met Gly Pro Arg Gly Leu 2610 2615 2620 Lys Gly Glu Arg Gly Val Lys Gly Ala Cys Gly Leu Asp Gly Glu Lys 2625 2630 2635 2640 Gly Asp Lys Gly Glu Ala Gly Pro Pro Gly Arg Pro Gly Leu Ala Gly 2645 2650 2655 His Lys Gly Glu Met Gly Glu Pro Gly Val Pro Gly Gln Ser Gly Ala 2660 2665 2670 Pro Gly Lys Glu Gly Leu Ile Gly Pro Lys Gly Asp Arg Gly Phe Asp 2675 2680 2685 Gly Gln Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Glu Arg Gly 2690 2695 2700 Thr Pro Gly Ile Gly Gly Phe Pro Gly Pro Ser Gly Asn Asp Gly Ser 2705 2710 2715 2720 Ala Gly Pro Pro Gly Pro Pro Gly Ser Val Gly Pro Arg Gly Pro Glu 2725 2730 2735 Gly Leu Gln Gly Gln Lys Gly Glu Arg Gly Pro Pro Gly Glu Arg Val 2740 2745 2750 Val Gly Ala Pro Gly Val Pro Gly Ala Pro Gly Glu Arg Gly Glu Gln 2755 2760 2765 Gly Arg Pro Gly Pro Ala Gly Pro Arg Gly Glu Lys Gly Glu Ala Ala 2770 2775 2780 Leu Thr Glu Asp Asp Ile Arg Gly Phe Val Arg Gln Glu Met Ser Gln 2785 2790 2795 2800 His Cys Ala Cys Gln Gly Gln Phe Ile Ala Ser Gly Ser Arg Pro Leu 2805 2810 2815 Pro Ser Tyr Ala Ala Asp Thr Ala Gly Ser Gln Leu His Ala Val Pro 2820 2825 2830 Val Leu Arg Val Ser His Ala Glu Glu Glu Glu Arg Val Pro Pro Glu 2835 2840 2845 Asp Asp Glu Tyr Ser Glu Tyr Ser Glu Tyr Ser Val Glu Glu Tyr Gln 2850 2855 2860 Asp Pro Glu Ala Pro Trp Asp Ser Asp Asp Pro Cys Ser Leu Pro Leu 2865 2870 2875 2880 Asp Glu Gly Ser Cys Thr Ala Tyr Thr Leu Arg Trp Tyr His Arg Ala 2885 2890 2895 Val Thr Gly Ser Thr Glu Ala Cys His Pro Phe Val Tyr Gly Gly Cys 2900 2905 2910 Gly Gly Asn Ala Asn Arg Phe Gly Thr Arg Glu Ala Cys Glu Arg Arg 2915 2920 2925 Cys Pro Pro Arg Val Val Gln Ser Gln Gly Thr Gly Thr Ala Gln Asp 2930 2935 2940 <210> 27 <211> 119 <212> PRT <213> Homo sapiens <400> 27 Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 1 5 10 15 Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 20 25 30 Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 35 40 45 Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 50 55 60 Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 65 70 75 80 Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 85 90 95 Leu Pro Ile Gln Thr Ala Glu Leu Ala Pro Glu Leu Val Ile Ser Asn 100 105 110 Asp Lys Arg Ser Phe Cys His 115 <210> 28 <211> 1205 <212> PRT <213> Homo sapiens <400> 28 Met Val Lys Cys Tyr His Lys Lys Tyr Arg Ser Ala Thr Arg Asp Val 1 5 10 15 Ile Phe Arg Leu Gln Phe His Thr Gly Ala Val Gln Gly Tyr Gly Leu 20 25 30 Val Phe Gly Lys Glu Asp Leu Asp Asn Ala Ser Lys Asp Asp Arg Phe 35 40 45 Pro Asp Tyr Gly Lys Val Glu Leu Val Phe Ser Ala Thr Pro Glu Lys 50 55 60 Ile Gln Gly Ser Glu His Leu Tyr Asn Asp His Gly Val Ile Val Asp 65 70 75 80 Tyr Asn Thr Thr Asp Pro Leu Ile Arg Trp Asp Ser Tyr Glu Asn Leu 85 90 95 Ser Ala Asp Gly Glu Val Leu His Thr Gln Gly Pro Val Asp Gly Ser 100 105 110 Leu Tyr Ala Lys Val Arg Lys Lys Ser Ser Ser Asp Pro Gly Ile Pro 115 120 125 Gly Gly Pro Gln Ala Ile Pro Ala Thr Asn Ser Pro Asp His Ser Asp 130 135 140 His Thr Leu Ser Val Ser Ser Asp Ser Gly His Ser Thr Ala Ser Ala 145 150 155 160 Arg Thr Asp Lys Thr Glu Glu Arg Leu Ala Pro Gly Thr Arg Arg Gly 165 170 175 Leu Ser Ala Gln Glu Lys Ala Glu Leu Asp Gln Leu Leu Ser Gly Phe 180 185 190 Gly Leu Glu Asp Pro Gly Ser Ser Leu Lys Glu Met Thr Asp Ala Arg 195 200 205 Ser Lys Tyr Ser Gly Thr Arg His Val Val Pro Ala Gln Val His Val 210 215 220 Asn Gly Asp Ala Ala Leu Lys Asp Arg Glu Thr Asp Ile Leu Asp Asp 225 230 235 240 Glu Met Pro His His Asp Leu His Ser Val Asp Ser Leu Gly Thr Leu 245 250 255 Ser Ser Ser Glu Gly Pro Gln Ser Ala His Leu Gly Pro Phe Thr Cys 260 265 270 His Lys Ser Ser Gln Asn Ser Leu Leu Ser Asp Gly Phe Gly Ser Asn 275 280 285 Val Gly Glu Asp Pro Gln Gly Thr Leu Val Pro Asp Leu Gly Leu Gly 290 295 300 Met Asp Gly Pro Tyr Glu Arg Glu Arg Thr Phe Gly Ser Arg Glu Pro 305 310 315 320 Lys Gln Pro Gln Pro Leu Leu Arg Lys Pro Ser Val Ser Ala Gln Met 325 330 335 Gln Ala Tyr Gly Gln Ser Ser Tyr Ser Thr Gln Thr Trp Val Arg Gln 340 345 350 Gln Gln Met Val Val Ala His Gln Tyr Ser Phe Ala Pro Asp Gly Glu 355 360 365 Ala Arg Leu Val Ser Arg Cys Pro Ala Asp Asn Pro Gly Leu Val Gln 370 375 380 Ala Gln Pro Arg Val Pro Leu Thr Pro Thr Arg Gly Thr Ser Ser Arg 385 390 395 400 Val Ala Val Gln Arg Gly Val Gly Ser Gly Pro His Pro Pro Asp Thr 405 410 415 Gln Gln Pro Ser Pro Ser Lys Ala Phe Lys Pro Arg Phe Pro Gly Asp 420 425 430 Gln Val Val Asn Gly Ala Gly Pro Glu Leu Ser Thr Gly Pro Ser Pro 435 440 445 Gly Ser Pro Thr Leu Asp Ile Asp Gln Ser Ile Glu Gln Leu Asn Arg 450 455 460 Leu Ile Leu Glu Leu Asp Pro Thr Phe Glu Pro Ile Pro Thr His Met 465 470 475 480 Asn Ala Leu Gly Ser Gln Ala Asn Gly Ser Val Ser Pro Asp Ser Val 485 490 495 Gly Gly Gly Leu Arg Ala Ser Ser Arg Leu Pro Asp Thr Gly Glu Gly 500 505 510 Pro Ser Arg Ala Thr Gly Arg Gln Gly Ser Ser Ala Glu Gln Pro Leu 515 520 525 Gly Gly Arg Leu Arg Lys Leu Ser Leu Gly Gln Tyr Asp Asn Asp Ala 530 535 540 Gly Gly Gln Leu Pro Phe Ser Lys Cys Ala Trp Gly Lys Ala Gly Val 545 550 555 560 Asp Tyr Ala Pro Asn Leu Pro Pro Phe Pro Ser Pro Ala Asp Val Lys 565 570 575 Glu Thr Met Thr Pro Gly Tyr Pro Gln Asp Leu Asp Ile Ile Asp Gly 580 585 590 Arg Ile Leu Ser Ser Lys Glu Ser Met Cys Ser Thr Pro Ala Phe Pro 595 600 605 Val Ser Pro Glu Thr Pro Tyr Val Lys Thr Ala Leu Arg His Pro Pro 610 615 620 Phe Ser Pro Pro Glu Pro Pro Leu Ser Ser Pro Ala Ser Gln His Lys 625 630 635 640 Gly Gly Arg Glu Pro Arg Ser Cys Pro Glu Thr Leu Thr His Ala Val 645 650 655 Gly Met Ser Glu Ser Pro Ile Gly Pro Lys Ser Thr Met Leu Arg Ala 660 665 670 Asp Ala Ser Ser Thr Pro Ser Phe Gln Gln Ala Phe Ala Ser Ser Cys 675 680 685 Thr Ile Ser Ser Asn Gly Pro Gly Gln Arg Arg Glu Ser Ser Ser Ser 690 695 700 Ala Glu Arg Gln Trp Val Glu Ser Ser Pro Lys Pro Met Val Ser Leu 705 710 715 720 Leu Gly Ser Gly Arg Pro Thr Gly Ser Pro Leu Ser Ala Glu Phe Ser 725 730 735 Gly Thr Arg Lys Asp Ser Pro Val Leu Ser Cys Phe Pro Pro Ser Glu 740 745 750 Leu Gln Ala Pro Phe His Ser His Glu Leu Ser Leu Ala Glu Pro Pro 755 760 765 Asp Ser Leu Ala Pro Pro Ser Ser Gln Ala Phe Leu Gly Phe Gly Thr 770 775 780 Ala Pro Val Gly Ser Gly Leu Pro Pro Glu Glu Asp Leu Gly Ala Leu 785 790 795 800 Leu Ala Asn Ser His Gly Ala Ser Pro Thr Pro Ser Ile Pro Leu Thr 805 810 815 Ala Thr Gly Ala Ala Asp Asn Gly Phe Leu Ser His Asn Phe Leu Thr 820 825 830 Val Ala Pro Gly His Ser Ser His His Ser Pro Gly Leu Gln Gly Gln 835 840 845 Gly Val Thr Leu Pro Gly Gln Pro Pro Leu Pro Glu Lys Lys Arg Ala 850 855 860 Ser Glu Gly Asp Arg Ser Leu Gly Ser Val Ser Pro Ser Ser Ser Gly 865 870 875 880 Phe Ser Ser Pro His Ser Gly Ser Thr Ile Ser Ile Pro Phe Pro Asn 885 890 895 Val Leu Pro Asp Phe Ser Lys Ala Ser Glu Ala Ala Ser Pro Leu Pro 900 905 910 Asp Ser Pro Gly Asp Lys Leu Val Ile Val Lys Phe Val Gln Asp Thr 915 920 925 Ser Lys Phe Trp Tyr Lys Ala Asp Ile Ser Arg Glu Gln Ala Ile Ala 930 935 940 Met Leu Lys Asp Lys Glu Pro Gly Ser Phe Ile Val Arg Asp Ser His 945 950 955 960 Ser Phe Arg Gly Ala Tyr Gly Leu Ala Met Lys Val Ala Thr Pro Pro 965 970 975 Pro Ser Val Leu Gln Leu Asn Lys Lys Ala Gly Asp Leu Ala Asn Glu 980 985 990 Leu Val Arg His Phe Leu Ile Glu Cys Thr Pro Lys Gly Val Arg Leu 995 1000 1005 Lys Gly Cys Ser Asn Glu Pro Tyr Phe Gly Ser Leu Thr Ala Leu Val 1010 1015 1020 Cys Gln His Ser Ile Thr Pro Leu Ala Leu Pro Cys Lys Leu Leu Ile 1025 1030 1035 1040 Pro Glu Arg Asp Pro Leu Glu Glu Ile Ala Glu Ser Ser Pro Gln Thr 1045 1050 1055 Ala Ala Asn Ser Ala Ala Glu Leu Leu Lys Gln Gly Ala Ala Cys Asn 1060 1065 1070 Val Trp Tyr Leu Asn Ser Val Glu Met Glu Ser Leu Thr Gly His Gln 1075 1080 1085 Ala Ile Gln Lys Ala Leu Ser Ile Thr Leu Val Gln Glu Pro Pro Pro 1090 1095 1100 Val Ser Thr Val Val His Phe Lys Val Ser Ala Gln Gly Ile Thr Leu 1105 1110 1115 1120 Thr Asp Asn Gln Arg Lys Leu Phe Phe Arg Arg His Tyr Pro Val Asn 1125 1130 1135 Ser Val Ile Phe Cys Ala Leu Asp Pro Gln Asp Arg Lys Trp Ile Lys 1140 1145 1150 Asp Gly Pro Ser Ser Lys Val Phe Gly Phe Val Ala Arg Lys Gln Gly 1155 1160 1165 Ser Ala Thr Asp Asn Val Cys His Leu Phe Ala Glu His Asp Pro Glu 1170 1175 1180 Gln Pro Ala Ser Ala Ile Val Asn Phe Val Ser Lys Val Met Ile Gly 1185 1190 1195 1200 Ser Pro Lys Lys Val 1205 <210> 29 <211> 620 <212> PRT <213> Homo sapiens <400> 29 Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 1 5 10 15 Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 20 25 30 Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 35 40 45 Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 50 55 60 Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 65 70 75 80 Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 85 90 95 Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 100 105 110 Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 115 120 125 Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 130 135 140 Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 145 150 155 160 Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 165 170 175 Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Glu Leu Asp His Thr Pro 180 185 190 Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 195 200 205 Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 210 215 220 Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 225 230 235 240 Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 245 250 255 Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 260 265 270 Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 275 280 285 Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 290 295 300 Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 305 310 315 320 Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 325 330 335 Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 340 345 350 Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 355 360 365 Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 370 375 380 Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 385 390 395 400 Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 405 410 415 His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 420 425 430 Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 435 440 445 Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 450 455 460 Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 465 470 475 480 Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Met As As Ala 485 490 495 Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 500 505 510 Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 515 520 525 Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 530 535 540 Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr 545 550 555 560 Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala 565 570 575 Ser Thr Tyr Ser Glu Phe Ala Lys Asp Pro Ser Leu Ser Asp Ser Ser 580 585 590 Thr Val Gly Leu Gln Arg Glu Leu Ser Lys Ala Ser Lys Ser Asp Ala 595 600 605 Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser 610 615 620 <210> 30 <211> 90 <212> PRT <213> Homo sapiens <400> 30 Met Arg Asp Pro Val Ser Ser Gln Tyr Ser Ser Phe Leu Phe Trp Arg 1 5 10 15 Met Pro Ile Pro Glu Leu Asp Leu Ser Glu Leu Glu Gly Leu Gly Leu 20 25 30 Ser Asp Thr Ala Thr Tyr Lys Val Lys Asp Ser Ser Val Gly Lys Met 35 40 45 Ile Gly Gln Ala Thr Ala Ala Asp Gln Glu Lys Asn Pro Glu Gly Asp 50 55 60 Gly Leu Leu Glu Tyr Ser Thr Phe Asn Phe Trp Arg Ala Pro Ile Ala 65 70 75 80 Ser Ile His Ser Phe Glu Leu Asp Leu Leu 85 90 <210> 31 <211> 763 <212> PRT <213> Homo sapiens <400> 31 Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 1 5 10 15 Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 20 25 30 Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 35 40 45 Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 50 55 60 Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 65 70 75 80 Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 85 90 95 Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 100 105 110 Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 115 120 125 Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 130 135 140 Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 145 150 155 160 Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 165 170 175 Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 180 185 190 Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 195 200 205 Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 210 215 220 Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 225 230 235 240 Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 245 250 255 Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 260 265 270 Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 275 280 285 Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 290 295 300 Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 305 310 315 320 Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 325 330 335 His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 340 345 350 Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 355 360 365 Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 370 375 380 Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 385 390 395 400 Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 405 410 415 Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 420 425 430 Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 435 440 445 Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 450 455 460 Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 465 470 475 480 Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 485 490 495 Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 500 505 510 Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 515 520 525 Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 530 535 540 Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 545 550 555 560 Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 565 570 575 Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 580 585 590 Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 595 600 605 Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 610 615 620 Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 625 630 635 640 Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 645 650 655 Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 660 665 670 Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 675 680 685 Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 690 695 700 Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 705 710 715 720 Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 725 730 735 Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 740 745 750 Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 755 760 <210> 32 <211> 464 <212> PRT <213> Homo sapiens <400> 32 Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser 1 5 10 15 Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly 20 25 30 Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys 35 40 45 Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg 50 55 60 Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys 65 70 75 80 Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser 85 90 95 Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu 100 105 110 Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu 115 120 125 Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser 130 135 140 Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe 145 150 155 160 Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp 165 170 175 Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu 180 185 190 Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys 195 200 205 Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu 210 215 220 Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu 225 230 235 240 Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr 245 250 255 Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr 260 265 270 Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg 275 280 285 Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile 290 295 300 Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu 305 310 315 320 Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr 325 330 335 Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu 340 345 350 Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu 355 360 365 Asp Arg Gln His Val Gln His Gln Leu Leu Val Ile Leu Lys Glu Leu 370 375 380 Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu 385 390 395 400 His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr 405 410 415 Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala 420 425 430 Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro 435 440 445 Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys 450 455 460 <210> 33 <211> 318 <212> PRT <213> Homo sapiens <400> 33 Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 1 5 10 15 Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 20 25 30 Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 35 40 45 Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 50 55 60 Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 65 70 75 80 Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 85 90 95 Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 100 105 110 Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 115 120 125 Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 130 135 140 Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 145 150 155 160 Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 165 170 175 Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 180 185 190 Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 195 200 205 Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 210 215 220 Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 225 230 235 240 Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 245 250 255 Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 260 265 270 Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 275 280 285 Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 290 295 300 Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 305 310 315 <210> 34 <211> 250 <212> PRT <213> Homo sapiens <400> 34 Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 1 5 10 15 Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 20 25 30 Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 35 40 45 Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 50 55 60 Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 65 70 75 80 Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 85 90 95 Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 100 105 110 Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 115 120 125 Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 130 135 140 Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 145 150 155 160 Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 165 170 175 Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 180 185 190 Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 195 200 205 Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 210 215 220 Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 225 230 235 240 Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 245 250 <210> 35 <211> 152 <212> PRT <213> Homo sapiens <400> 35 Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys 1 5 10 15 Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile 20 25 30 Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly 35 40 45 Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe 50 55 60 Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp 65 70 75 80 Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu 85 90 95 Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile 100 105 110 Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp 115 120 125 Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro 130 135 140 Thr Asp Pro Ala Asp Gly Pro Val 145 150 <210> 36 <211> 497 <212> PRT <213> Homo sapiens <400> 36 Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 1 5 10 15 Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 20 25 30 Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 35 40 45 Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 50 55 60 Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 65 70 75 80 Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 85 90 95 Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 100 105 110 Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 115 120 125 Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 130 135 140 Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 145 150 155 160 His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 165 170 175 Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 180 185 190 Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 195 200 205 Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 210 215 220 Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 225 230 235 240 Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 245 250 255 Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 260 265 270 Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 275 280 285 Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 290 295 300 Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 305 310 315 320 Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 325 330 335 His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 340 345 350 Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 355 360 365 Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 370 375 380 Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 385 390 395 400 Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 405 410 415 Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 420 425 430 Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 435 440 445 Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 450 455 460 Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 465 470 475 480 Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 485 490 495 Gln <210> 37 <211> 334 <212> PRT <213> Homo sapiens <400> 37 Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 1 5 10 15 Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 20 25 30 Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln 35 40 45 Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 50 55 60 Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 65 70 75 80 Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 85 90 95 Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 100 105 110 Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 115 120 125 Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 130 135 140 Ala Gly Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 145 150 155 160 Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr 165 170 175 Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 180 185 190 Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 195 200 205 Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn 210 215 220 Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 225 230 235 240 Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 245 250 255 Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 260 265 270 Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 275 280 285 Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly 290 295 300 Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 305 310 315 320 Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser 325 330 <210> 38 <211> 168 <212> PRT <213> Homo sapiens <400> 38 Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 1 5 10 15 Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 20 25 30 Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 35 40 45 Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 50 55 60 Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 65 70 75 80 Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 85 90 95 Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 100 105 110 Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 115 120 125 Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 130 135 140 Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 145 150 155 160 Lys Lys Gln Glu Lys Met Leu Asp 165 <210> 39 <211> 316 <212> PRT <213> Homo sapiens <400> 39 Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 1 5 10 15 Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val 20 25 30 Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 35 40 45 Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 50 55 60 Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 65 70 75 80 Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr 85 90 95 Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 100 105 110 Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 115 120 125 Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala 130 135 140 Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 145 150 155 160 Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 165 170 175 Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr 180 185 190 Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr 195 200 205 Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 210 215 220 Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 225 230 235 240 His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg 245 250 255 Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu 260 265 270 Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr 275 280 285 Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys 290 295 300 Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 305 310 315 <210> 40 <211> 384 <212> PRT <213> Homo sapiens <400> 40 Met Ala Ile Ala Tyr Leu Gly Ser Ser Cys Pro Ser Gln Pro Pro Ser 1 5 10 15 Ser Leu Ala Leu Ser Leu Ser Pro Thr Pro Ser Asp Phe Glu Gln Glu 20 25 30 Ser Gly Ile Glu Thr Ala Met Arg Phe Ser Pro Asp Val Ala Leu Ala 35 40 45 Val Ser Thr Thr Pro Ala Val Leu Pro Thr Thr Asn Ile Gln Pro Val 50 55 60 Gly Thr Pro Phe Glu Glu Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro 65 70 75 80 Ala Thr Ser Pro Leu Val Val Thr Glu Val Pro Glu Glu Pro Ser Gln 85 90 95 Arg Ala Thr Thr Val Ser Thr Thr Met Ala Thr Thr Ala Ala Thr Ser 100 105 110 Thr Gly Asp Pro Thr Val Ala Thr Val Pro Ala Thr Val Ala Thr Ala 115 120 125 Thr Pro Ser Thr Pro Ala Ala Pro Pro Phe Thr Ala Thr Thr Ala Val 130 135 140 Ile Arg Thr Thr Gly Val Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr 145 150 155 160 Val Ala Thr Ala Arg Ala Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr 165 170 175 Thr Ala Ala Val Leu Asp Thr Glu Ala Pro Thr Pro Arg Leu Val Ser 180 185 190 Thr Ala Thr Ser Arg Pro Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln 195 200 205 Glu Pro Asp Ile Pro Glu Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala 210 215 220 Pro Gly Pro Thr Glu Val Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu 225 230 235 240 Thr Thr Ile Arg Asp Glu Pro Glu Val Pro Val Ser Gly Gly Pro Ser 245 250 255 Gly Asp Phe Glu Leu Pro Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala 260 265 270 Asn Glu Val Val Ala Val Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro 275 280 285 Pro Gly Thr Leu Pro Lys Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp 290 295 300 Asn Ala Ile Asp Ser Gly Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser 305 310 315 320 Ile Leu Glu Arg Lys Glu Val Leu Val Ala Val Ile Val Gly Gly Val 325 330 335 Val Gly Ala Leu Phe Ala Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg 340 345 350 Met Lys Lys Lys Asp Glu Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln 355 360 365 Ala Ser Val Thr Tyr Gln Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 370 375 380 <210> 41 <211> 211 <212> PRT <213> Homo sapiens <400> 41 Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 1 5 10 15 Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210 <210> 42 <211> 322 <212> PRT <213> Homo sapiens <400> 42 Met Leu Ser Pro Leu Pro Thr Gly Pro Leu Glu Ala Cys Phe Ser Val 1 5 10 15 Gln Ser Arg Thr Ser Ser Pro Met Glu Pro Pro Ile Pro Gln Ser Ala 20 25 30 Pro Leu Thr Pro Asn Ser Val Met Val Gln Pro Leu Leu Asp Ser Arg 35 40 45 Met Ser His Ser Arg Leu Gln His Pro Leu Thr Ile Leu Pro Ile Asp 50 55 60 Gln Val Lys Thr Ser His Val Glu Asn Asp Tyr Ile Asp Asn Pro Ser 65 70 75 80 Leu Ala Leu Thr Thr Gly Pro Lys Arg Thr Arg Gly Gly Ala Pro Glu 85 90 95 Leu Ala Pro Thr Pro Ala Arg Cys Asp Gln Asp Val Thr His His Trp 100 105 110 Ile Ser Phe Ser Gly Arg Pro Ser Ser Val Ser Ser Ser Ser Ser Thr 115 120 125 Ser Ser Asp Gln Arg Leu Leu Asp His Met Ala Pro Pro Pro Val Ala 130 135 140 Asp Gln Ala Ser Pro Arg Ala Val Arg Ile Gln Pro Lys Val Val His 145 150 155 160 Cys Gln Pro Leu Asp Leu Lys Gly Pro Ala Val Pro Pro Glu Leu Asp 165 170 175 Lys His Phe Leu Leu Cys Glu Ala Cys Gly Lys Cys Lys Cys Lys Glu 180 185 190 Cys Ala Ser Pro Arg Thr Leu Pro Ser Cys Trp Val Cys Asn Gln Glu 195 200 205 Cys Leu Cys Ser Ala Gln Thr Leu Val Asn Tyr Gly Thr Cys Met Cys 210 215 220 Leu Val Gln Gly Ile Phe Tyr His Cys Thr Asn Glu Asp Asp Glu Gly 225 230 235 240 Ser Cys Ala Asp His Pro Cys Ser Cys Ser Arg Ser Asn Cys Cys Ala 245 250 255 Arg Trp Ser Phe Met Gly Ala Leu Ser Val Val Leu Pro Cys Leu Leu 260 265 270 Cys Tyr Leu Pro Ala Thr Gly Cys Val Lys Leu Ala Gln Arg Gly Tyr 275 280 285 Asp Arg Leu Arg Arg Pro Gly Cys Arg Cys Lys His Thr Asn Ser Val 290 295 300 Ile Cys Lys Ala Ala Ser Gly Asp Ala Lys Thr Ser Arg Pro Asp Lys 305 310 315 320 Pro phe <210> 43 <211> 623 <212> PRT <213> Homo sapiens <400> 43 Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys 1 5 10 15 Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala 20 25 30 Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met 35 40 45 Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg 50 55 60 Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro 65 70 75 80 Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu 85 90 95 Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val 100 105 110 Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly 115 120 125 Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys 130 135 140 Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu 145 150 155 160 Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp 165 170 175 Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro 180 185 190 Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala 195 200 205 Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu 210 215 220 Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ila 225 230 235 240 Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser 245 250 255 Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln 260 265 270 Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro 275 280 285 Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro 290 295 300 Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala 305 310 315 320 Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile 325 330 335 Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys 340 345 350 Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Gln Asn 355 360 365 Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro 370 375 380 Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile 385 390 395 400 Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His 405 410 415 Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu 420 425 430 Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro 435 440 445 Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr 450 455 460 Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile 465 470 475 480 Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu 485 490 495 Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu 500 505 510 His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn 515 520 525 Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu 530 535 540 Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu 545 550 555 560 Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val 565 570 575 Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val 580 585 590 Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp 595 600 605 Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala 610 615 620 <210> 44 <211> 178 <212> PRT <213> Homo sapiens <400> 44 Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 1 5 10 15 Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 20 25 30 Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 35 40 45 Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 50 55 60 Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 65 70 75 80 Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 85 90 95 Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 100 105 110 Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 115 120 125 Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 130 135 140 Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 145 150 155 160 Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 165 170 175 Cys arg <210> 45 <211> 228 <212> PRT <213> Homo sapiens <400> 45 Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 1 5 10 15 Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 20 25 30 Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 35 40 45 Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 50 55 60 Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 65 70 75 80 Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 85 90 95 Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 100 105 110 His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 115 120 125 Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 130 135 140 Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Val Glu 145 150 155 160 Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 165 170 175 Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 180 185 190 Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 195 200 205 Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 210 215 220 Arg Glu Met Val 225 <210> 46 <211> 239 <212> PRT <213> Homo sapiens <400> 46 Met Ala Lys Pro Cys Gly Val Arg Leu Ser Gly Glu Ala Arg Lys Gln 1 5 10 15 Val Glu Val Phe Arg Gln Asn Leu Phe Gln Glu Ala Glu Glu Phe Leu 20 25 30 Tyr Arg Phe Leu Pro Gln Lys Ile Tyr Leu Asn Gln Leu Leu Gln 35 40 45 Glu Asp Ser Leu Asn Val Ala Asp Leu Thr Ser Leu Arg Ala Pro Leu 50 55 60 Asp Ile Pro Ile Pro Asp Pro Pro Pro Lys Asp Asp Glu Met Glu Thr 65 70 75 80 Asp Lys Gln Glu Lys Lys Glu Val His Lys Cys Gly Phe Leu Pro Gly 85 90 95 Asn Glu Lys Val Leu Ser Leu Leu Ala Leu Val Lys Pro Glu Val Trp 100 105 110 Thr Leu Lys Glu Lys Cys Ile Leu Val Ile Thr Trp Ile Gln His Leu 115 120 125 Ile Pro Lys Ile Glu Asp Gly Asn Asp Phe Gly Val Ala Ile Gln Glu 130 135 140 Lys Val Leu Glu Arg Val Asn Ala Val Lys Thr Lys Val Glu Ala Phe 145 150 155 160 Gln Thr Thr Ile Ser Lys Tyr Phe Ser Glu Arg Gly Asp Ala Val Ala 165 170 175 Lys Ala Ser Lys Glu Thr His Val Met Asp Tyr Arg Ala Leu Val His 180 185 190 Glu Arg Asp Glu Ala Ala Tyr Gly Glu Leu Arg Ala Met Val Leu Asp 195 200 205 Leu Arg Ala Phe Tyr Ala Glu Leu Tyr His Ile Ile Ser Ser Asn Leu 210 215 220 Glu Lys Ile Val Asn Pro Lys Gly Glu Glu Lys Pro Ser Met Tyr 225 230 235 <210> 47 <211> 672 <212> PRT <213> Homo sapiens <400> 47 Met Ala Asp Gly Ser Leu Thr Gly Gly Gly Leu Glu Ala Ala Ala Met 1 5 10 15 Ala Pro Glu Arg Thr Gly Trp Ala Val Glu Gln Glu Leu Ala Ser Leu 20 25 30 Glu Lys Gly Leu Phe Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr 35 40 45 Arg Asp Lys Pro Gly Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys 50 55 60 Thr Phe Phe Pro Glu Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu 65 70 75 80 Arg Phe Arg Ala Tyr Gln Asp Tyr Ile Leu Ala Asp Cys Lys Ala Ser 85 90 95 Glu Val Gln Glu Phe Thr Ala Glu Phe Leu Glu Lys Val Leu Glu Pro 100 105 110 Ser Gly Trp Arg Ala Val Trp His Thr Asn Val Phe Lys Val Leu Val 115 120 125 Glu Ile Thr Asp Val Asp Phe Ala Ala Leu Lys Ala Val Val Arg Leu 130 135 140 Ala Glu Pro Tyr Leu Cys Asp Ser Gln Val Ser Thr Phe Thr Met Glu 145 150 155 160 Cys Met Lys Glu Leu Leu Asp Leu Lys Glu His Arg Leu Pro Leu Gln 165 170 175 Glu Leu Trp Val Val Phe Asp Asp Ser Gly Val Phe Asp Gln Thr Ala 180 185 190 Leu Ala Ile Glu His Val Arg Phe Phe Tyr Gln Asn Ile Trp Arg Ser 195 200 205 Trp Asp Glu Glu Glu Glu Asp Glu Tyr Asp Tyr Phe Val Arg Cys Val 210 215 220 Glu Pro Arg Leu Arg Leu His Tyr Asp Ile Leu Glu Asp Arg Val Pro 225 230 235 240 Ser Gly Leu Ile Val Asp Tyr His Asn Leu Leu Ser Gln Cys Glu Glu 245 250 255 Ser Tyr Arg Lys Phe Leu Asn Leu Arg Ser Ser Leu Ser Asn Cys Asn 260 265 270 Ser Asp Ser Glu Gln Glu Asn Ile Ser Met Val Glu Gly Leu Lys Leu 275 280 285 Tyr Ser Glu Met Glu Gln Leu Lys Gln Lys Leu Lys Leu Ile Glu Asn 290 295 300 Pro Leu Leu Arg Tyr Val Phe Gly Tyr Gln Lys Asn Ser Asn Ile Gln 305 310 315 320 Ala Lys Gly Val Arg Ser Ser Gly Gln Lys Ile Thr His Val Val Ser 325 330 335 Ser Thr Met Met Ala Gly Leu Leu Arg Ser Leu Leu Thr Asp Arg Leu 340 345 350 Cys Gln Glu Pro Gly Glu Glu Glu Arg Glu Ile Gln Phe His Ser Asp 355 360 365 Pro Leu Ser Ala Ile Asn Ala Cys Phe Glu Gly Asp Thr Val Ile Val 370 375 380 Cys Pro Gly His Tyr Val Val His Gly Thr Phe Ser Ile Ala Asp Ser 385 390 395 400 Ile Glu Leu Glu Gly Tyr Gly Leu Pro Asp Asp Ile Val Ile Glu Lys 405 410 415 Arg Gly Lys Gly Asp Thr Phe Val Asp Cys Thr Gly Ala Asp Ile Lys 420 425 430 Ile Ser Gly Ile Lys Phe Val Gln His Asp Ala Val Glu Gly Ile Leu 435 440 445 Ile Val His Arg Gly Lys Thr Thr Leu Glu Asn Cys Val Leu Gln Cys 450 455 460 Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala Glu Phe Leu Met Lys 465 470 475 480 Asn Ser Asp Leu Tyr Gly Ala Lys Gly Ala Gly Ile Glu Ile Tyr Pro 485 490 495 Gly Ser Gln Cys Thr Leu Ser Asp Asn Gly Ile His His Cys Lys Glu 500 505 510 Gly Ile Leu Ile Lys Asp Phe Leu Asp Glu His Tyr Asp Ile Pro Lys 515 520 525 Ile Ser Met Val Asn Asn Ile Ile His Asn Asn Glu Gly Tyr Gly Val 530 535 540 Val Leu Val Lys Pro Thr Ile Phe Ser Asp Leu Gln Glu Ser Ala Glu 545 550 555 560 Asp Gly Thr Glu Glu Asn Lys Ala Leu Lys Ile Gln Thr Ser Gly Glu 565 570 575 Pro Asp Val Ala Glu Arg Val Asp Leu Glu Glu Leu Ile Glu Cys Ala 580 585 590 Thr Gly Lys Met Glu Leu Cys Ala Arg Thr Asp Pro Ser Glu Gln Val 595 600 605 Glu Gly Asn Cys Glu Ile Val Asn Glu Leu Ile Ala Ala Ser Thr Gln 610 615 620 Lys Gly Gln Ile Lys Lys Lys Arg Leu Ser Glu Leu Gly Ile Thr Gln 625 630 635 640 Ala Asp Asp Asn Leu Met Ser Gln Glu Met Phe Val Gly Ile Val Gly 645 650 655 Asn Gln Phe Lys Trp Asn Gly Lys Gly Ser Phe Gly Thr Phe Leu Phe 660 665 670 <210> 48 <211> 963 <212> PRT <213> Homo sapiens <400> 48 Met Ala Ala Gln Arg Ile Arg Ala Ala Asn Ser Asn Gly Leu Pro Arg 1 5 10 15 Cys Lys Ser Glu Gly Thr Leu Ile Asp Leu Ser Glu Gly Phe Ser Glu 20 25 30 Thr Ser Phe Asn Asp Ile Lys Val Pro Ser Pro Ser Ala Leu Leu Val 35 40 45 Asp Asn Pro Thr Pro Phe Gly Asn Ala Lys Glu Val Ile Ala Ile Lys 50 55 60 Asp Tyr Cys Pro Thr Asn Phe Thr Thr Leu Lys Phe Ser Lys Gly Asp 65 70 75 80 His Leu Tyr Val Leu Asp Thr Ser Gly Gly Glu Trp Trp Tyr Ala His 85 90 95 Asn Thr Thr Glu Met Gly Tyr Ile Pro Ser Ser Tyr Val Gln Pro Leu 100 105 110 Asn Tyr Arg Asn Ser Thr Leu Ser Asp Ser Gly Met Ile Asp Asn Leu 115 120 125 Pro Asp Ser Pro Asp Glu Val Ala Lys Glu Leu Glu Leu Leu Gly Gly 130 135 140 Trp Thr Asp Asp Lys Lys Val Pro Gly Arg Met Tyr Ser Asn Asn Pro 145 150 155 160 Phe Trp Asn Gly Val Gln Thr Asn Pro Phe Leu Asn Gly Asn Val Pro 165 170 175 Val Met Pro Ser Leu Asp Glu Leu Asn Pro Lys Ser Thr Val Asp Leu 180 185 190 Leu Leu Phe Asp Ala Gly Thr Ser Ser Phe Thr Glu Ser Ser Ser Ala 195 200 205 Thr Thr Asn Ser Thr Gly Asn Ile Phe Asp Glu Leu Pro Val Thr Asn 210 215 220 Gly Leu His Ala Glu Pro Pro Val Arg Arg Asp Asn Pro Phe Phe Arg 225 230 235 240 Ser Lys Arg Ser Tyr Ser Leu Ser Glu Leu Ser Val Leu Gln Ala Lys 245 250 255 Ser Asp Ala Pro Thr Ser Ser Ser Phe Phe Thr Gly Leu Lys Ser Pro 260 265 270 Ala Pro Glu Gln Phe Gln Ser Arg Glu Asp Phe Arg Thr Ala Trp Leu 275 280 285 Asn His Arg Lys Leu Ala Arg Ser Cys His Asp Leu Asp Leu Leu Gly 290 295 300 Gln Ser Pro Gly Trp Gly Gln Thr Gln Ala Val Glu Thr Asn Ile Val 305 310 315 320 Cys Lys Leu Asp Ser Ser Gly Gly Ala Val Gln Leu Pro Asp Thr Ser 325 330 335 Ile Ser Ile His Val Pro Glu Gly His Val Ala Pro Gly Glu Thr Gln 340 345 350 Gln Ile Ser Met Lys Ala Leu Leu Asp Pro Pro Leu Glu Leu Asn Ser 355 360 365 Asp Arg Ser Cys Ser Ile Ser Pro Val Leu Glu Val Lys Leu Ser Asn 370 375 380 Leu Glu Val Lys Thr Ser Ile Ile Leu Glu Met Lys Val Ser Ala Glu 385 390 395 400 Ile Lys Asn Asp Leu Phe Ser Lys Ser Thr Val Gly Leu Gln Cys Leu 405 410 415 Arg Ser Asp Ser Lys Glu Gly Pro Tyr Val Ser Val Pro Leu Asn Cys 420 425 430 Ser Cys Gly Asp Thr Val Gln Ala Gln Leu His Asn Leu Glu Pro Cys 435 440 445 Met Tyr Val Ala Val Val Ala His Gly Pro Ser Ile Leu Tyr Pro Ser 450 455 460 Thr Val Trp Asp Phe Ile Asn Lys Lys Val Thr Val Gly Leu Tyr Gly 465 470 475 480 Pro Lys His Ile His Pro Ser Phe Lys Thr Val Val Thr Ile Phe Gly 485 490 495 His Asp Cys Ala Pro Lys Thr Leu Leu Val Ser Glu Val Thr Arg Gln 500 505 510 Ala Pro Asn Pro Ala Pro Val Ala Leu Gln Leu Trp Gly Lys His Gln 515 520 525 Phe Val Leu Ser Arg Pro Gln Asp Leu Lys Val Cys Met Phe Ser Asn 530 535 540 Met Thr Asn Tyr Glu Val Lys Ala Ser Glu Gln Ala Lys Val Val Arg 545 550 555 560 Gly Phe Gln Leu Lys Leu Gly Lys Val Ser Arg Leu Ile Phe Pro Ile 565 570 575 Thr Ser Gln Asn Pro Asn Glu Leu Ser Asp Phe Thr Leu Arg Val Gln 580 585 590 Val Lys Asp Asp Gln Glu Ala Ile Leu Thr Gln Phe Cys Val Gln Thr 595 600 605 Pro Gln Pro Pro Lys Ser Ala Ile Lys Pro Ser Gly Gln Arg Arg 610 615 620 Phe Leu Lys Lys Asn Glu Val Gly Lys Ile Ile Leu Ser Pro Phe Ala 625 630 635 640 Thr Thr Thr Lys Tyr Pro Thr Phe Gln Asp Arg Pro Val Ser Ser Leu 645 650 655 Lys Phe Gly Lys Leu Leu Lys Thr Val Val Arg Gln Asn Lys Asn His 660 665 670 Tyr Leu Leu Glu Tyr Lys Lys Gly Asp Gly Ile Ala Leu Leu Ser Glu 675 680 685 Glu Arg Val Arg Leu Arg Gly Gln Leu Trp Thr Lys Glu Trp Tyr Ile 690 695 700 Gly Tyr Tyr Gln Gly Arg Val Gly Leu Val His Thr Lys Asn Val Leu 705 710 715 720 Val Val Gly Arg Ala Arg Pro Ser Leu Cys Ser Gly Pro Glu Leu Ser 725 730 735 Thr Ser Val Leu Leu Glu Gln Ile Leu Arg Pro Cys Lys Phe Leu Thr 740 745 750 Tyr Ile Tyr Ala Ser Val Arg Thr Leu Leu Met Glu Asn Ile Ser Ser 755 760 765 Trp Arg Ser Phe Ala Asp Ala Leu Gly Tyr Val Asn Leu Pro Leu Thr 770 775 780 Phe Phe Cys Arg Ala Glu Leu Asp Ser Glu Pro Glu Arg Val Ala Ser 785 790 795 800 Val Leu Glu Lys Leu Lys Glu Asp Cys Asn Asn Thr Glu Asn Lys Glu 805 810 815 Arg Lys Ser Phe Gln Lys Glu Leu Val Met Ala Leu Leu Lys Met Asp 820 825 830 Cys Gln Gly Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr 835 840 845 Thr Ala Val Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu 850 855 860 Ala Lys Val Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg 865 870 875 880 Asp Arg Asn Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr 885 890 895 Asp Phe Leu Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp 900 905 910 Val Ile Gln Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile 915 920 925 Thr Lys Arg Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser 930 935 940 Leu Asp Val Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp 945 950 955 960 Phe Val Ile <210> 49 <211> 359 <212> PRT <213> Homo sapiens <400> 49 Thr Asn Lys Leu Glu Gln Pro Arg Gly Gln Glu Phe Trp Ala Asp Leu 1 5 10 15 Asn Ala Met Asn Val Tyr Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg 20 25 30 Leu Ser Thr Pro Pro Ser Ser Asn Val Asn Ser Ile Tyr His Thr Val 35 40 45 Trp Lys Phe Phe Cys Arg Asp His Phe Gly Trp Arg Glu Tyr Pro Glu 50 55 60 Ser Val Ile Arg Leu Ile Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu 65 70 75 80 Val Arg Phe Met Met Trp Asn Asn His Tyr Ile Leu His Asn Ser Phe 85 90 95 Phe Arg Arg Glu Ile Lys Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile 100 105 110 Leu Leu Pro Tyr Leu Gln Thr Leu Gly Gly Val Pro Thr Gln Ala Pro 115 120 125 Pro Pro Leu Glu Ala Thr Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly 130 135 140 Val Thr Ser Ala Asn Phe Tyr Pro Glu Thr Trp Val Tyr Met His Pro 145 150 155 160 Ser Gln Asp Phe Ile Gln Val Pro Val Ser Ala Glu Asp Lys Ser Tyr 165 170 175 Arg Ile Ile Tyr Asn Leu Phe His Lys Thr Val Pro Glu Phe Lys Tyr 180 185 190 Arg Ile Leu Gln Ile Leu Arg Val Gln Asn Gln Phe Leu Trp Glu Lys 195 200 205 Tyr Lys Arg Lys Lys Glu Tyr Met Asn Arg Lys Met Phe Gly Arg Asp 210 215 220 Arg Ile Ile Asn Glu Arg His Leu Phe His Gly Thr Ser Gln Asp Val 225 230 235 240 Val Asp Gly Ile Cys Lys His Asn Phe Asp Pro Arg Val Cys Gly Lys 245 250 255 His Ala Thr Met Phe Gly Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser 260 265 270 Tyr Ser His Asn Phe Ser Lys Lys Ser Ser Lys Gly Val His Phe Met 275 280 285 Phe Leu Ala Lys Val Leu Thr Gly Arg Tyr Thr Met Gly Ser His Gly 290 295 300 Met Arg Arg Pro Pro Pro Val Asn Pro Gly Ser Val Thr Ser Asp Leu 305 310 315 320 Tyr Asp Ser Cys Val Asp Asn Phe Phe Glu Pro Gln Ile Phe Val Ile 325 330 335 Phe Asn Asp Asp Gln Ser Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu 340 345 350 Val Ser Asn Thr Val Ser Ile 355

Claims

서열번호 1에서 서열번호 25로 구성된 군으로부터 선택된 하나의 모낭형성 능력을 갖는 유전자. A gene having one hair follicle forming ability selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 25.

콜라겐형 VII(서열번호26), DNA 바인딩 3 저해제(서열번호27), 종양 엔도쎄리얼 마커 6(서열번호28), 사이토키네시스1의 단백질 조절자(서열번호 29), 염색체1q(ch 1q)의 올(ALL)1-융합된 유전자를 코딩하는 단백질(서열번호 30), 포크헤드 박스 M1(서열번호31), 가상(hypothetical) 단백질 FLJ10540(서열번호32), 감마-굴루타밀 하이드로레이즈(서열번호33), 가상 단백질 MGC5576(서열번호34), 프로테오리피드 단백질 2(서열번호35), 가상 단백질 DKFZp434B044(서열번호36), S-아데노실메티오닌 디카르복실레이즈 1(서열번호37), 프레이오트로핀(서열번호38), 알도-케토·리덕테이즈 B1(서열번호39), 신데칸 3(서열번호40), 메탈로프로테이즈 3 조직 인히비터(TIMP-3)(서열번호41), 스프로티 호모로지 4(서열번호42), 트랜스케토레이즈(서열번호43), FXYD 도메인 5(서열번호44), CD9 항원(p24)(서열번호45) 및 프로테오좀 액티베이터 단위체2(서열번호46), 가상 단백질 FLJ22009(서열번호47), SH3-도메인(서열번호48) 및 DKFZp434J214(서열번호49) 단백질로 구성된 군으로부터 선택된 하나의 모낭형성능력을 갖는 단백질.Collagen type VII (SEQ ID NO: 26), DNA binding 3 inhibitor (SEQ ID NO: 27), tumor endothelial marker 6 (SEQ ID NO: 28), protein regulator of cytokines 1 (SEQ ID NO: 29), chromosome 1q (ch 1q) Protein encoding the ALL1-fusion gene (SEQ ID NO: 30), forkhead box M1 (SEQ ID NO: 31), hypothetical protein FLJ10540 (SEQ ID NO: 32), gamma-gullutamyl hydrolase (SEQ ID NO: 33), Virtual Protein MGC5576 (SEQ ID NO: 34), Proteolipid Protein 2 (SEQ ID NO: 35), Virtual Protein DKFZp434B044 (SEQ ID NO: 36), S-adenosylmethionine decarboxylase 1 (SEQ ID NO: 37) , Freiotropin (SEQ ID NO: 38), Aldo-Keto-Reductase B1 (SEQ ID NO: 39), Syndecan 3 (SEQ ID NO: 40), Metalloprotease 3 tissue inhibitor (TIMP-3) (SEQ ID NO: 41), Sprotty homology 4 (SEQ ID NO: 42), transketose (SEQ ID NO: 43), FXYD domain 5 (SEQ ID NO: 44), CD9 antigen (p24) (SEQ ID NO: 45) and Protein having one hair follicle forming ability selected from the group consisting of proteosome activator unit 2 (SEQ ID NO: 46), hypothetical protein FLJ22009 (SEQ ID NO: 47), SH3-domain (SEQ ID NO: 48), and DKFZp434J214 (SEQ ID NO: 49) protein .