KR20020013675A - Antibiotic and cosmetic compositions containing herb medicines - Google Patents

Antibiotic and cosmetic compositions containing herb medicines Download PDF

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KR20020013675A
KR20020013675A KR1020000047075A KR20000047075A KR20020013675A KR 20020013675 A KR20020013675 A KR 20020013675A KR 1020000047075 A KR1020000047075 A KR 1020000047075A KR 20000047075 A KR20000047075 A KR 20000047075A KR 20020013675 A KR20020013675 A KR 20020013675A
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yellow
extract
herbal
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licorice
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KR100417791B1 (en
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정종각
김용수
김윤사
이영하
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김윤사
미즈코리아 주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

PURPOSE: Provided is an antibiotic activity and a cosmetic composition containing medicinal herb extract including licorice, Sophora flavescens, citrus trifoliate, Belamcanda chinensis (L.) DC., Malaphis chinensis (Bell), bamboo shoot, Cnidium officinale, Scutellaria baicalensis Georgi or Scutellaria baicalensis Georgi. CONSTITUTION: The antibiotic composition contains at least two kinds of medicinal herb extracts selected from the group consisting of licorice, Sophora flavescens, citrus trifoliate, Belamcanda chinensis (L.) DC., Malaphis chinensis (Bell), bamboo shoot, Cnidium officinale, Scutellaria baicalensis Georgi or Scutellaria baicalensis Georgi (each 0.01-50 wt.%), wherein extract solvent is selected from water, alcohol, such as methanol or ethanol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerine, ether or their mixture.

Description

항균 및 미용기능을 갖는 생약추출물과 이를 함유한 제품{Antibiotic and cosmetic compositions containing herb medicines}Herbal extracts with antibacterial and cosmetic functions and products containing them {Antibiotic and cosmetic compositions containing herb medicines}

본 발명은 복합 생약 추출물을 함유하는 항균제 및 화장료 조성물에 관한 것으로, 특히 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 또는 황백 추출물을 함유하는 항균제 및 화장료 조성물에 관한 것이다.The present invention relates to an antimicrobial and cosmetic composition containing a complex herbal extract, and more particularly to an antimicrobial and cosmetic composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, cheongung, golden, yellow lotus or sulfur white extract.

항균제는 현재 많은 종류가 제품화되어 병에 대한 예방 및 치료 목적으로 널리사용되고 있다.Many antimicrobials are currently commercialized and are widely used for the prevention and treatment of diseases.

항균제는 항균력에 따라 항진균제 및 항세균제로 나눌 수 있는데 항진균제는 곰팡이와 같은 진핵세포를 갖는 고등생물의 성장을 억제 또는 살균하는 기능을 갖는다.Antibacterial agents can be divided into antifungal agents and antibacterial agents according to their antibacterial activity. Antifungal agents have a function of inhibiting or sterilizing the growth of higher organisms having eukaryotic cells such as fungi.

또한 항세균제는 박테리아(세균류)등과 같은 원핵세포를 갖는 하등생물의 성장을 억제 또는 살균하는 기능을 갖는 항생제를 말한다.In addition, an antibacterial agent refers to an antibiotic having a function of inhibiting or sterilizing the growth of lower organisms having prokaryotic cells such as bacteria (bacteria).

현재까지는 주로 항균제(항진균, 항세균제)는 곰팡이 등에서 얻어내거나 또는 화학적으로 합성하여 얻어내고 있다.Until now, mainly antibacterial agents (antifungal agents, antibacterial agents) have been obtained from molds or chemically synthesized.

이들 항진균제로는 예를 들어, 암포테리신 비(Amphotericin B), 클로트리마졸(Clotrimazole), 크리니판 에이디(Crinipan A D), 플루코나졸(Fluconazole), 그리세오풀빈(Griseofulvin),할로프로긴(Haloprogin),헥사클로로펜(Hexachlorophene),이크티올(Ichthyol),이트라코나졸(Itraconazole),케토코나졸(Ketoconazole),마이코나졸(Miconazole), 나이스타틴(Nystatin: 마이코스타틴(Mycostatin)), 피마리신 (Pimaricin : 나타마이신(Natamycin)), 테르비나파인(Terbinafine) 등이 있다.These antifungal agents include, for example, Amphotericin B, Clotrimazole, Crinipan AD, Fluconazole, Griseofulvin, Haloprogin. Hexachlorophene, Ichthyol, Itraconazole, Ketoconazole, Myconazole, Miconazole, Nystatin (Mycostatin), Pimaricin (Nattamycin) Natamycin)) and Terbinafine.

또, 항세균제로는 예를 들어, 아다팔렌 겔(Adapalene gel), 벤조일 퍼옥사이드(Benzoyl peroxide), 후시딘산(Fusidic acid), 레조키놀(Resorcinol), 레티논산 (Retinoic acid), 살리실산(Salicylic acid), 설폰아미드(Sulfonamide), 테트라싸이클린(Tetracycline), 트리클로산(Trichlosan), 페니실린(Penicillin) 등이 있다.As antibacterial agents, for example, Adapalene gel, Benzoyl peroxide, Fusidic acid, Resorcinol, Retinoic acid, Salicylic acid ), Sulfonamide, Tetracycline, Triclosan, Penicillin, and the like.

그러나, 이러한 합성 항진균 및 항세균제는 제조비용이 많이 들고 정제과정 등이 까다롭고 제품화되어 사용시 미생물의 내성이 증가하는 부작용이 있었다. 또한, 미용기능에 대한 부분이 검토되지 않아 연고제 등으로 도포하는 경우 원하지 않는 피부 트러블(접촉피부염) 및 부작용이 수반되어 많은 연구자들에 의해 부작용이 없으면서 목적하는 항진균 및 항세균 기능을 갖는 항생제 개발이 진행중인 것으로 알려져 있다.However, these synthetic antifungal and antimicrobial agents have high side-effects such as high manufacturing costs, difficult purification processes, and increased commercialization of microorganisms. In addition, since the cosmetic function has not been reviewed and applied with an ointment, it is accompanied by unwanted skin trouble (contact dermatitis) and side effects, and many researchers have developed antibiotics having the desired antifungal and antibacterial function without side effects. It is known to be in progress.

따라서 본 발명의 목적은 피부 트러블 등의 부작용이 없는 항균제 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide an antimicrobial composition having no side effects such as skin troubles.

본 발명의 다른 목적은 한 종류의 균만이 아니라 피부병이나 피부 트러블을 일으키는 다양한 세균 및 진균에 작용하는 항균제 조성물을 제공하는 것이다.Another object of the present invention is to provide an antimicrobial composition that acts on not only one kind of bacteria but also various bacteria and fungi causing skin diseases and skin problems.

본 발명의 다른 목적은 항균 효과 및 피부 미용 개선 효능이 우수한 화장료 조성물을 제공하는 것이다.Another object of the present invention to provide a cosmetic composition excellent in antimicrobial effect and skin cosmetic improvement effect.

도 1은 본 발명의 생약 추출과정을 설명하기 위한 블럭도1 is a block diagram for explaining the herbal medicine extraction process of the present invention

도 2는 본 발명의 복합 생약 추출물의 무좀 유발균에 대한 항균 활성 시험 결과를 나타내는 사진.Figure 2 is a photograph showing the results of the antimicrobial activity test for athlete's foot fungus-inducing bacteria of the complex herbal extract of the present invention.

도 3은 본 발명의 복합 생약 추출물의 여드름 유발균에 대한 항균 활성 시험 결과를 나타내는 사진.Figure 3 is a photograph showing the antimicrobial activity test results for acne-inducing bacteria of the complex herbal extract of the present invention.

도 4는 본 발명의 복합 생약 추출물을 포함하는 제품을 무좀 환자에게 사용한 결과를 나타내는 사진.Figure 4 is a photograph showing the results of using the product containing a composite herbal extract of the present invention on athlete's foot.

도 5는 본 발명의 복합 생약 추출물을 포함하는 제품을 여드름 환자에게 사용한 결과를 나타내는 사진.Figure 5 is a photograph showing the results of using a product containing a complex herbal extract of the present invention to acne patients.

도 6은 본 발명의 복합 생약 추출물을 포함하는 제품을 아토피성 피부염 환자에게 사용한 결과를 나타내는 사진.Figure 6 is a photograph showing the results of using the product containing the complex herbal extract of the present invention in atopic dermatitis patients.

상기 본 발명의 목적은 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 또는 황백 추출물을 함유하는 항균제 조성물에 의해 달성된다.The object of the present invention is achieved by an antimicrobial composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, celestial organs, golden, yellow lotus or yellow white extract.

상기 본 발명의 목적은 또한, 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 또는 황백 추출물을 함유하는 화장료 조성물에 의해 달성된다.The object of the present invention is also achieved by a cosmetic composition containing licorice, red ginseng, alum, dead liver, gall bladder, bamboo shoots, celestial arches, golden, yellow lotus or yellow white extract.

본 발명자들은 기존의 항균제(항진균, 항세균)와는 달리, 여러 가지 생약을대상으로 이를 여러 용매를 사용 추출, 정제한 후 피부트러블 유발균 (여드름, 무좀, 칸디다증, 질염등)에 적용, 항균성이 있는 생약을 스크리닝하고, 각 생약을 복합 처방하여 피부병이나 피부 트러블을 일으키는 다양한 세균 및 진균에 효과가 있는 조성물을 얻게 되었다.The present inventors, unlike conventional antibacterial agents (antifungal, antibacterial), extracted and purified using a variety of solvents for various herbal drugs applied to skin trouble causing bacteria (acne, athlete's foot, candidiasis, vaginitis, etc.), antibacterial Screening of herbal medicines, and combining each herbal medicine to obtain a composition that is effective in a variety of bacteria and fungi causing skin diseases and skin problems.

또한 개발된 생약 추출물은 생약 각각 및 복합 추출물에 대하여 피부 부작용 시험을 실시하였으며 미용기능(미백, 수렴, 각질제거, 항산화, 잔주름제거, 보습, 영양 공급, 항알레르기, UV 차단효과 등)에 대한 효능시험을 행한 결과, 본 발명의 복합 생약 추출물이 다양한 미용 효능이 있음을 알게 되었다.In addition, the developed herbal extracts were tested for side effects of each herbal extract and complex extracts.Efficacy on beauty functions (whitening, astringent, exfoliation, antioxidant, wrinkle removal, moisturizing, nutrition, anti-allergy, UV blocking effect, etc.) As a result of the test, it was found that the herbal extract of the present invention has various cosmetic effects.

본 발명은 다양한 생약 추출물을 피부병(피부트러블)을 일으키는 병원성 미생물(세균, 진균, 원충 등)에 적용하여 시험하였다.The present invention was tested by applying various herbal extracts to pathogenic microorganisms (bacteria, fungi, protozoa, etc.) that cause skin diseases (skin problems).

시험에 사용된 병원성 미생물(피부트러블 유발균)은 다음과 같다.Pathogenic microorganisms (skin trouble-causing bacteria) used in the test are as follows.

① 여드름 유발균(1종) :Propionibacterium acnes ① Acne-causing bacteria (1 type): Propionibacterium acnes

② 무좀(백선)유발균 (5종) :Epidermophyton floccosum ② Athlete's foot ( lineworm ) -inducing bacteria (5 species): Epidermophyton floccosum

Microsporum audouiniiMicrosporum audouinii

Trichophyton ferrugineumTrichophyton ferrugineum

Trichophyton mentagrophytesTrichophyton mentagrophytes

Trichophyton rubrumTrichophyton rubrum

③ 비듬유발균(1종) :Pityrosporum ovale ③ Dandruff-induced bacteria (1 type): Pityrosporum ovale

④ 외음질염 또는 항문주위 칸디다증 유발균 (1종) :Candida albicans ④ vulvitis or perianal candidiasis-inducing bacteria (1 type): Candida albicans

⑤ 성병(여성질염, 요도염, 방광염등과 남성의 요도염)⑤ Sexually transmitted diseases (feminitis, urethritis, cystitis and men's urethritis)

유발균(1종) :Trichomonas vaginalis Causative bacteria (1 species): Trichomonas vaginalis

위 시험 균주는 균주은행(한국 과학기술원 유전자 은행)으로부터 분양받아 시험하였다.The above test strain was tested from the strain bank (Korea Advanced Institute of Science and Technology Gene Bank).

본 발명자는 우선 동의보감, 중약대사전, 본초학, 천연물과학, 대한약전, 생약(生藥)규격집, 약초의 성분과 이용, 생약학등과 학술자료에서 항균효과가 있다고 알려진 생약들을 대상으로 조사한 바 총 255종의 생약이 피부병(무좀, 백선, 비듬, 외음부 및 항문 칸디다증을 유발하는 표재성 진균증과 여드름 및 피부트러블을 일으키는 세균성 질환등)유발균에 항균효과가 있다고 조사되었다.The inventors of the present invention first investigated the herbal medicine known as antimicrobial effect in consent consent, Chinese herbal medicine dictionary, herbal medicine, natural product science, Korean herbal medicine, herbal medicine standard, herbal medicine ingredients, herbal medicine, etc. Herbal medicines have been shown to have antimicrobial effects on skin diseases (such as athlete's foot, ringworm, dandruff, vulva and anal candidiasis), and superficial fungi that cause acne and skin problems.

이들 생약중 국내 및 외국에서 구입하기 힘들거나 매우 고가의 생약은 경제성과 다량 생산 체계시의 문제점을 감안 실험에서 제외하여 본 시험에 사용된 생약은 총 155종으로 이들 생약 추출물을 위 병원 미생물에 적용하여 그 항균활성을 확인한 바, 상당수의 생약 추출물에서는 항균 활성이 없거나 미약하였다.Of these herbal medicines, which are difficult or expensive to purchase in Korea and foreign countries, 155 kinds of herbal medicines used in this test were excluded from the experiment in consideration of economic and mass production system problems. As a result of confirming the antimicrobial activity, a large number of herbal extracts had no or weak antimicrobial activity.

특이한 것은 실험균 모두에 효과가 뛰어난 생약이 있는가 하면 어떤 생약은 세균류인 여드름 유발균에 대해서만 효과가 뛰어나고 곰팡이류인 무좀, 외음질염 유발균에 대해서는 항균활성이 없었으며, 다른 생약은 같은 무좀을 일으키는 진균 5종에 대 해서도 그 항균활성의 정도에 차이가 많은 것이 확인되었다.What is unusual is that there are some herbal medicines that are effective for all experimental bacteria. Some herbal medicines are only effective against acne-causing bacteria, and fungi and athletes have no antimicrobial activity. It was also confirmed that there were many differences in the degree of antimicrobial activity against five species.

공통적으로 비듬 유발균에 대한 항균활성은 대부분의 생약 추출물(유효농도)에서 확인되지 않았다.In general, antimicrobial activity against dandruff causing bacteria was not found in most herbal extracts (effective concentrations).

또한 어떠한 생약은 항균활성은 미약하지만 미용기능에 뛰어난 효과를 발휘하였으며 이와는 반대로 항균효과는 뛰어났으나 피부부작용시험(Patch test)에서양성 반응을 보여 본 발명의 생약에서 제외시킨 것도 있다.In addition, some herbal medicines have a weak antimicrobial activity, but have an excellent effect on cosmetic function. On the contrary, the antimicrobial effect was excellent, but a positive reaction was observed in the patch test.

이와 같은 항균 활성과 미용기능 시험에서 우수한 생약 추출물을 선별한 후, 혼합하여 전체 활성을 시험하는 과정으로 본 발명의 복합 생약 추출물을 개발하게 되었다.After selecting an excellent herbal extract in the antimicrobial activity and cosmetic function test as described above, the composite herbal extract of the present invention was developed by mixing and testing the total activity.

실험을 위한 생약시료 준비 과정은 첨부하는 도 1에 도시되어 있다.The herbal sample preparation process for the experiment is shown in FIG.

먼저, 각각의 생약제를 구입하여 준비한 다음, 품질검사를 실시하고, 세척하여 추출을 행한다. 추출 용매로는 물, 메탄올 또는 에탄올 등의 알콜, 1,3-부틸렌글리콜, 프로필렌 글리콜, 폴리에틸렌 글리콜, 글리세린, 에테르, 또는 이들의 혼합 용매 등을 사용할 수 있다. 추출물의 비율이 10중량% 정도가 되도록 추출한 다음, 여과 및 정제한다. 원심분리기를 이용하여 원심분리한 후, 여과하여 식이섬유 등을 제거하고 활성탄(Active carbon)을 사용하여 색소를 제게한다. 이렇게 제조된 1차 시료를 대상으로 항균활성 및 미용기능 시험을 각각 행하여 시험결과에서 효과가 인정되는 것에 대하여 추출용매로 희석한 2차시료를 준비한다. 예를 들면,First, each herbal medicine is purchased and prepared, followed by quality inspection, washing and extraction. As the extraction solvent, alcohol such as water, methanol or ethanol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerin, ether, or a mixed solvent thereof may be used. Extract so that the ratio of the extract is about 10% by weight, then filtered and purified. After centrifugation using a centrifuge, filtered to remove dietary fibers, etc., and the pigments are removed using activated carbon. Antimicrobial activity and cosmetic function tests were carried out on the primary samples thus prepared, and a secondary sample diluted with an extraction solvent was prepared for the effect recognized in the test results. For example,

·10% 생약추출물을 1/10로 희석 1% 생약추출물을 만듬.Dilute 10% herbal extract to 1/10 to make 1% herbal extract.

·1% 생약추출물을 1/10로 희석 0.1% 생약추출물을 만듬.Dilute 1% herbal extract to 1/10 to make 0.1% herbal extract.

·0.1% 생약추출물을 1/10로 희석 0.01% 생약추출물을 만듬.Dilute 0.1% herbal extract to 1/10 to make 0.01% herbal extract.

이렇게 제조된 2차시료중 항균 및 미용효과가 뛰어난 시료를 재조합하여 만들거나, 재조합 대상이 되는 생약을 복합 추출하여 3차 시료를 제조한다.The secondary sample prepared in this way is made by recombining a sample having excellent antimicrobial and cosmetic effects, or by extracting a crude compound to be recombinant target to prepare a third sample.

본 발명의 복합 생약 추출물에는 기타의 생약부원료, 예를 들어, 감송향, 강활, 고본, 계피, 금은화, 녹각, 녹용, 당귀, 독활, 마치현, 만년청, 목향, 박하,백강잠, 백급, 백부, 백부자, 백복령, 백렴, 백지, 백편두, 석창포, 상백피, 세신, 상엽, 소회향(회향), 알로에, 애엽(쑥), 인삼, 영지, 의이인, 유근피, 은행, 원지, 자초근(자근), 작약, 죽염, 지각, 지유, 지황, 포공영(민들레), 천궁, 택사, 행인, 황기, 황정, 해동피 중 하나 이상을 부가할 수 있다.Complex herbal extracts of the present invention include other herbal medicines, for example, saengyanghyang, strong, hardy, cinnamon, gold and silver, green rust, antler, donkey, poisonous, machi, fountain blue, Mokhyang, peppermint, Baekjajam, Baekbaek, Baekbu, Baekjaja , Baekbokryeong, Baeknyeo, Baekji, Baekpyeon, Seokchangpo, Sangbaekpi, Sesin, Sangup, Small Fennel (Fennel), Aloe, Amaryllis, Ginseng, Ganoderma, Euiin, Yugeunpi, Ginkgo, Wonji, Japonica root One or more of the following elements can be added: crust, fat milk, jihwang, pogongyoung (dandelion), celestial arch, taxi, passerby, hwanggi, hwangjeong, haedongpi.

본 발명의 복합 생약 추출물은 비누류, 세정제류 (외음부 세정제, 샴푸, 목욕용품류, 신체의 전부 또는 일부 사용 목적의 세정제), 의약부외품/의약품, 화장품(로션, 스킨, 맛사지 크림, 영양 크림 등) 및 마사지팩류, 양말등의 면류제품 등으로 제조될 수 있다.Complex herbal extract of the present invention is soaps, detergents (vulva cleaner, shampoo, bath products, cleaners for all or part of the body), quasi-drugs / pharmaceuticals, cosmetics (lotion, skin, massage cream, nutrition cream, etc.) ) And noodle products, such as massage packs and socks.

상기 비누, 세정제, 의약품, 화장품으로 제조되는 경우, 그 제형은 액상, 겔상, 분말, 과립, 고형, 유화액, 현탁액, 크림, 연고, 스프레이, 마스크, 거즈, 필터, 양말 등으로 다양하게 제조될 수 있으며, 특별한 제한은 없다.In the case of the soap, detergent, medicine, cosmetics, the formulation may be prepared in various forms such as liquid, gel, powder, granule, solid, emulsion, suspension, cream, ointment, spray, mask, gauze, filter, socks, etc. There is no special limitation.

항균효과 (항세균, 항진균) 확인을 위한 시험조건 및 시험방법은 하기 표 1에 기재하였고, 이 조건 및 방법에 의해 실시된 본 발명의 각 생약 성분(1차 시료)의 시험결과는 하기 표 2에 기재하였다.Test conditions and test methods for identifying the antimicrobial effect (antibacterial, antifungal) are described in Table 1 below, and the test results of each herbal ingredient (primary sample) of the present invention carried out by the conditions and methods are shown in Table 2 below. It is described in.

표 1. 항균 시험 조건 및 방법Table 1. Antimicrobial Test Conditions and Methods

표 2 항균 효능 시험 결과Table 2 Antimicrobial Efficacy Test Results

미용 효능 확인을 위한 시험조건 및 시험방법은 하기 표 3에 기재하였고, 이조건 및 방법에 의해 실시된 본 발명의 생약 성분의 시험결과는 하기 표 4에 기재하였다.Test conditions and test methods for confirming cosmetic efficacy are described in Table 3 below, and the test results of the herbal ingredients of the present invention carried out by these conditions and methods are described in Table 4 below.

표 3. 미용효과 확인을 위한 시험조건 및 방법Table 3. Test conditions and methods for confirming cosmetic effects

표 4. 미용 효능 시험 결과Table 4. Results of cosmetic efficacy test

상기 실험에서 효능이 확인된 각 생약을 조합하거나, 재조합 대상이 되는 생약을 복합 추출하여 제조한 3차 시료에 대한 항균 및 미용 효능 시험결과는 하기 표 5에 기재하였다. 복합생약추출물의 시료농도는 최적의 용매를 사용 생약 기준 0.15% 용액 (복합 생약 추출물 1.5%에 해당)으로 하였다.The antimicrobial and cosmetic efficacy test results of the tertiary samples prepared by combining the respective herbal medicines confirmed in the above experiments or extracting the herbal compound to be recombinant are described in Table 5 below. The sample concentration of the compound herbal extract was set to 0.15% solution (corresponding to 1.5% of the compound herbal extract) based on the herbal standard using the optimal solvent.

도 2 내지 3에는 무좀 유발균과 여드름 유발균의 항균활성 시험을 상기 표 1에 기재된 바와 같이, 종이 디스크, 컵, 및 액체 배양 방법으로 한 경우의 실험결과를 사진으로 나타내었다. 생약기준 0.02-0.15%(복합 생약 추출물 0.2-1.5% 해당) 이하에서 생육최소저지농도(MIC)가 확인되었다.2 to 3, the antimicrobial activity test of the athlete's foot-inducing bacteria and acne-inducing bacteria as shown in Table 1, the experimental results when the paper disk, the cup, and the liquid culture method is shown in the photograph. Minimum growth concentration (MIC) was found below the herbal standard 0.02-0.15% (combined herbal extract 0.2-1.5%).

복합 생약 추출물의 무좀균에 대한 각 균주별 MIC는E.floccosum(1.0%),M.audouinii(1.5%),T.ferrugineum(1.0%),T.mentagrophytes(0.5%),T.rubrum(1.0%) 이하임을 확인하였고, 여드름 유발균의 경우P.acnes(0.02%) 이하임을 확인하였다.The MIC of each strain against athlete's foot fungus of E.floccosum (1.0%), M.audouinii (1.5%), T.ferrugineum (1.0%), T.mentagrophytes (0.5%), and T.rubrum (1.0%) It was confirmed that less than, P. acnes (0.02%) in the case of acne-inducing bacteria.

표 5. 복합 생약 추출물의 항세균 및 미용효과 시험결과Table 5. Test result of antibacterial and cosmetic effect of complex herbal extract

* 기호표시의 설명 : ++++ 매우뛰어남, +++뛰어남, ++효과있음, +효과약함, - 효과없음* Explanation of Symbols: ++++ Very good, +++ Excellent, ++ Effective, + Effective,-No effect

본 발명의 복합 생약 추출물은 비누, 화장료, 의약품 등 다양한 제형으로 제품화 될 수 있으며, 예를 들어 하기의 처방예가 있다.Complex herbal extract of the present invention can be commercialized in a variety of formulations, such as soaps, cosmetics, pharmaceuticals, for example, the following prescription examples.

또한, 본 발명의 생약 추출물을 무좀 치료를 위해 사용하는 경우, 예를 들어 담배 필터 모양의, 거즈에 포장된 탈지면에 추출물을 흡수시킨 다음 그대로 사용하거나 건조시킨 제형으로 제조한 후, 사용시에 알콜 등에 적셔서 사용할 수 있도록 제조할 수도 있다. 이러한 형태로 제조하여 발가락 사이에 끼워 적용하는 경우 추출물의 효과를 향성시킬 수 있다.In addition, when the herbal extract of the present invention is used for treating athlete's foot, for example, tobacco extracts are absorbed into cotton wool wrapped in gauze, and then used as is or prepared in a dry formulation, and then alcohol or the like in use. It can also be manufactured so that it can be used wet. When prepared in this form and applied between the toes can be enhanced the effect of the extract.

처방예 1 비누(고형 비누)Prescription Example 1 Soap (Solid Soap)

처방예 2 외음부 세정제 (겔상 의약부외품기준)Prescription Example 2 Vulva Cleaner (gel-based quasi drug)

처방예 3. 로션Prescription Example 3. Lotion

처방예 4. 연고제Prescription Example 4. Ointment

처방예 5 액제 (의약품)Prescription Example 5 Liquid (Medicine)

실시예 1Example 1

상기 처방예 1의 처방대로 조제된 비누를 무좀 (백선)이 있는 환자에게 1일 2회 1개월간 사용하였다. 사용 전 후의 사진을 도 4에 게시하였다.Soap prepared according to the prescription of Formulation Example 1 was used twice a day for 1 month to a patient with athlete's foot (ringworm). Photos before and after use are posted in FIG. 4.

실시예 2Example 2

상기 처방예 4의 처방대로 조제된 연고를 여드름이 있는 환자에게 1일 2회 1개월간 사용하였다. 사용 전 후의 사진을 도 5에 게시하였다.The ointment prepared according to the prescription of Formulation Example 4 was used twice a day for 1 month to patients with acne. Photos before and after use are posted in FIG. 5.

실시예 3Example 3

상기 처방예 5의 처방대로 조제된 액제를 아토피성 피부염이 있는 소아 환자에게 1일 2회 1개월간 사용하였다. 사용 전 후의 사진을 도 6에 게시하였다.The liquid formulation prepared according to the prescription of Formula 5 was used twice a day for 1 month in a pediatric patient with atopic dermatitis. Photos before and after use are posted in FIG. 6.

상기 본 발명의 실험결과와 실시예에 의해 알 수 있는 바와 같이, 본 발명의 복합 생약 추출물은 우수한 항균 활성 및 미용기능을 갖는다. 본 발명의 복합 생약 추출물은 미백기능을 가지므로, 기미,주근깨, 검버섯 제거에 사용할 수 있고, 영양공급, 피부재생, 보습, 수렴, 잔주름제거, 노화억제, 각질제거, 자외선 차단 등을 목적으로 하는 화장품 제조에 이용할 수 있다. 또, 여드름, 무좀, 아토피성피부염, 알레르기성As can be seen by the experimental results and examples of the present invention, the complex herbal extract of the present invention has excellent antibacterial activity and cosmetic function. Complex herbal extract of the present invention has a whitening function, can be used to remove blemishes, freckles, black mushrooms, nutrition, skin regeneration, moisturizing, convergence, fine wrinkles removal, aging control, exfoliation, UV protection, etc. It can be used to manufacture cosmetics. In addition, acne, athlete's foot, atopic dermatitis, allergic

접촉 피부염, 외음부 가려움이나 항문주위의 발진, 민감성 피부 등의 피부병의 치료나 여성질염, 요도염, 방광염과 남성의 요도염 등에 대한 치료 및 개선을 목적으로 하는 의약품에 첨가할 수 있다.It can be added to medicines aimed at the treatment of dermatitis, such as contact dermatitis, vulva itch, perianal rash, and sensitive skin, and for the treatment and improvement of female vaginitis, urethritis, cystitis and men's urethritis.

Claims (10)

감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 및 황백 추출물로 구성되는 그룹으로부터 선택된 2종 이상의 생약 추출물을 각각 0.01-50중량% 포함하는 것을 특징으로 하는 항균제 조성물.An antimicrobial composition comprising 0.01-50% by weight each of two or more herbal extracts selected from the group consisting of licorice, red ginseng, alum, sagan, gall bladder, bamboo shoot, celestial organ, golden, yellow lotus and yellow white extract. 제 1 항에 있어서, 감송향, 강활, 고본, 계피, 금은화, 녹각, 녹용, 당귀, 독활, 마치현, 만년청, 목향, 박하, 백강잠, 백급, 백부, 백부자, 백복령, 백렴, 백지, 백편두, 석창포, 상백피, 세신, 상엽, 소회향(회향), 알로에, 애엽(쑥), 인삼, 영지, 의이인, 유근피, 은행, 원지, 자초근(자근), 작약, 죽염, 지각, 지유, 지황, 포공영(민들레), 천궁, 택사, 행인, 황기, 황정, 및 해동피로 구성되는 그룹으로부터 선택된 하나 이상의 생약 추출물을 더 포함하는 것을 특징으로 하는 항균제 조성물.The method according to claim 1, sensation incense, vigor, hard bones, cinnamon, gold and silver, green, antler, donkey, poisonous, machi, perennial, moth, peppermint, baekjap, baekpyeong, baekbu, baekbuja, baekbokyeong, baekryeom, baekji, baekpyeong, Seokchangpo, Sangbaekpi, Sessin, Upper Leaf, Small Fennel (Fennel), Aloe, Apple Leaf (Ginseng), Ginseng, Ganoderma lucidum, Ui In, Yu Geun-pi, Ginkgo, Wonji, Japonica root (Pea root), Peony, Bamboo salt, Crust, Jiyu, Jihwang, Pogongyoung Antimicrobial composition further comprises one or more herbal extracts selected from the group consisting of: cheongung, taxi, pedestrian, yellow, yellow, and thawed blood. 제 1 항 또는 제 2 항에 있어서, 상기 생약 추출물은 물, 메탄올 또는 에탄올 등의 알콜, 1,3-부틸렌 글리콜, 프로필렌 글리콜, 폴리에틸렌글리콜, 글리세린, 에테르, 또는 이들의 혼합 용매에 의해 추출된 추출물인 것을 특징으로 하는 항균제 조성물.According to claim 1 or 2, wherein the herbal extract is extracted with an alcohol such as water, methanol or ethanol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerin, ether, or a mixed solvent thereof Antimicrobial composition, characterized in that the extract. 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 및 황백 추출물로구성되는 그룹으로부터 선택된 2종 이상의 생약 추출물을 각각 0.01-50중량% 포함하는 것을 특징으로 하는 화장료 조성물.Cosmetic composition, characterized in that it comprises 0.01-50% by weight each of two or more herbal extracts selected from the group consisting of licorice, red ginseng, alum, mortar, gall bladder, bamboo shoot, celestial organ, golden, yellow lotus and yellow white extract. 제 4 항에 있어서, 감송향, 강활, 고본, 계피, 금은화, 녹각, 녹용, 당귀, 독활, 마치현, 만년청, 목향, 박하, 백강잠, 백급, 백부, 백부자, 백복령, 백렴, 백지, 백편두, 석창포, 상백피, 세신, 상엽, 소회향, 알로에, 애엽(쑥), 인삼, 영지, 의이인, 유근피, 은행, 원지, 자초근(자근), 작약, 죽염, 지각, 지유, 지황, 포공영(민들레), 천궁, 택사, 행인, 황기, 황정, 및 해동피로 구성되는 그룹으로부터 선택된 하나 이상의 생약 추출물을 더 포함하는 것을 특징으로 하는 화장료 조성물.The method according to claim 4, wherein the persimmon incense, vigor, hardwood, cinnamon, gold and silver, green, antler, donkey, poisonous, machi, perennial, moth, mint, baekjap, baekpyeong, baekbu, baekbuja, baekbokyeong, baekryeom, baekji, baekpyeong, Seokchangpo, Sangbaekpi, Sessin, Sangup, Sohhoe, Aloe, Amaryllis, Ginseng, Ganoderma lucidum, Ui-in, Yu Geun-pi, Ginkgo, Wonji, Japonica root, Peony, Bamboo salt, Crust, Jiyu, Jihwang, Pogongyoung (dandelion), Cheonggung Cosmetic composition, characterized in that it further comprises one or more herbal extracts selected from the group consisting of taxa, passersby, yellow, yellow, and thawed blood. 제 4 항 또는 제 5항에 있어서, 상기 생약 추출물은 물, 메탄올 또는 에탄올 등의 알콜, 1,3-부틸렌 글리콜, 프로필렌 글리콜, 폴리에틸렌글리콜, 글리세린, 에테르, 또는 이들의 혼합 용매에 의해 추출된 추출물인 것을 특징으로 하는 화장료 조성물.The method of claim 4 or 5, wherein the herbal extract is extracted with an alcohol such as water, methanol or ethanol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerin, ether, or a mixed solvent thereof Cosmetic composition, characterized in that the extract. 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 및 황백 추출물로 구성되는 그룹으로부터 선택된 2종 이상의 생약 추출물을 0.1-33.33중량% 포함하는 것을 특징으로 하는 비누.A soap comprising 0.1-33.33% by weight of two or more herbal extracts selected from the group consisting of licorice, red ginseng, alum, sagan, gall bladder, bamboo shoots, celestial organs, gold, yellow lotus and yellow white extract. 제 7 항에 있어서, 상기 비누는 고형 비누 또는 액체 세정제인 것을 특징으로 하는 비누.8. The soap of claim 7, wherein the soap is a solid soap or a liquid detergent. 감초, 고삼, 백반, 사간, 오배자, 죽순, 천궁, 황금, 황련 및 황백 추출물로 구성되는 그룹으로부터 선택된 2종 이상의 생약 추출물을 0.1-33.33중량% 흡수시킨 것을 특징으로 하는 거즈에 포장된 소독용 탈지면.Disinfectant cotton wool packaged in gauze, characterized by absorbing 0.1-33.33% by weight of two or more herbal extracts selected from the group consisting of licorice, red ginseng, alum, shrine, gall bladder, bamboo shoot, celery, golden, yellow lotus and yellow white extract . 제 9 항에 있어서, 상기 거즈에 포장된 탈지면은 담배 필터 형태로 성형된 것을 특징으로 하는 소독용 탈지면.10. The disinfecting cotton wool of claim 9, wherein the cotton wool packed in the gauze is molded in the form of a tobacco filter.
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