KR20220118664A - A Gami-Hwangryunhaedoktang hand sanitizer composition with anti-bacterial and moisturizing effect - Google Patents
A Gami-Hwangryunhaedoktang hand sanitizer composition with anti-bacterial and moisturizing effect Download PDFInfo
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Abstract
Description
본 발명은 항균 및 보습 효과를 보유한 가미황련해독탕을 유효성분으로 포함하는 손소독제 조성물에 관한 것이다. 본 발명에 따르는 조성물은 대장균, 황색포도상구균 및 Phi6 바이러스에 대한 항균 효능 및 보습 효능을 보유하고 있다.The present invention relates to a hand sanitizer composition comprising, as an active ingredient, Gamihwangryeon Haedok-tang having antibacterial and moisturizing effects. The composition according to the present invention has antibacterial and moisturizing effects against E. coli, Staphylococcus aureus and Phi6 virus.
황련해독탕은 황련(黃連), 황금(黃芩), 황백(黃柏) 및 치자(梔子)를 1첩 기준 각 5g을 혼합하여 전탕한 탕약으로서, 삼초에 열사(熱邪)가 성하여 가슴이 답답하고 안타까우며 입과 목이 마르고 높은 열이 나며 헛소리를 하고 잠을 잘 자지 못하는 데와 코피가 나고 출혈반이 생기는 데, 여러 가지 옹저(癰疽) 때 종독 증상이 심한데 쓴다. 여러 가지 급성 염증, 패혈증, 급성 폐렴, 고혈압, 주사비 등 때에 쓸 수 있다. Hwangryeonhaedoktang is a decoction made by mixing 5g each of Hwangryeon (黃連), Golden (黃芩), Hwangbaek (黃柏) and Gardenia (梔子) in 1 cheop. It is used for stuffy and sad, dry mouth and throat, high fever, talking nonsense, not being able to sleep well, nosebleeds and bleeding spots, and severe symptoms of poisoning in various ong-jeo. It can be used in various acute inflammations, sepsis, acute pneumonia, hypertension, rosacea, etc.
가미(加味)는 약을 지을 때, 환자의 상태에 따라 본래의 약방문에 적힌 약재의 중량비를 조정하거나 또는 약재를 빼거나 또는 다른 약재를 더 넣거나 하는 것을 말한다. 이에 따라 기존 처방의 효능이 강화되거나 또는 새로운 효능이 추가될 수도 있다. 따라서 가미 처방은 기존 처방의 약재를 활용한다는 점에서 기존 처방의 이름을 사용하지만 실제로는 새로운 처방이라고 할 수 있다.Gami (加味) refers to adjusting the weight ratio of the medicines written on the original medicine visit or adding other medicines or adding other medicines depending on the patient's condition when making medicine. Accordingly, the efficacy of the existing prescription may be enhanced or a new efficacy may be added. Therefore, Gami prescription uses the name of the existing prescription in that it utilizes the drugs of the existing prescription, but it is actually a new prescription.
본 출원 발명자는 소독제로 활용하고자 황련해독탕을 기본으로 하되 항균 효과와 보습효과를 보유하는 가미황련해독탕 소독제를 안출하였다. 즉 황금, 황련, 황백 및 치자 이외에 금은화, 연교, 청향 및 팔각회향을 추가하여 소독제 유효성분을 안출하였다.The inventor of the present application has devised a disinfectant based on Hwangryeonhaedoktang, but with antibacterial and moisturizing effects, to be used as a disinfectant. In other words, in addition to gold, yellow lily, yellow lily, and gardenia, an active ingredient for disinfectant was devised by adding gold ginseng, yeonkyo, cheongyang and octagonal fennel.
선행기술문헌을 살펴보면, 대한민국 등록특허공보 10-2199934에는 "황련해독탕의 김치유산균 발효물을 함유하는 여드름 개선용 화장료 조성물"이 기재되어 있다. 살펴보면, 락토바실러스 플랜타룸 균주로 발효시킨 황련해독탕 유산균 발효물을 유효성분으로 포함하는 것이 청구항 1에 기재되어 있다. 또한, 대한민국 등록특허공보 10-1819060에는 "황련해독탕 발효물을 유효성분으로 포함하는 화장료 조성물"이 기재되어 있다. 살펴보면, 류코노스톡 메센테로이데스로 발효된 황련해독탕 발효물을 유효성분으로 포함하는 것이 청구항 1에 기재되어 있다.Looking at the prior art literature, Republic of Korea Patent Publication No. 10-2199934 discloses "a cosmetic composition for improving acne containing fermented kimchi lactic acid bacteria of Hwangnyeonhaedoktang". Looking at it, it is described in claim 1 that the fermented product of Hwangryeonhaedoktang lactic acid bacteria fermented with a Lactobacillus plantarum strain as an active ingredient. In addition, Republic of Korea Patent Publication No. 10-1819060 describes "a cosmetic composition comprising a fermented product of Hwangnyeonhaedoktang as an active ingredient". Looking at it, it is described in claim 1 that the fermented product of Hwangryeonhaedoktang fermented with Leukonostok mecenteroides as an active ingredient.
정리하여 보면, 선행기술문헌들은 본 출원발명과 마찬가지로 황련해독탕에 근거한 외용제라는 점에서 유사하긴 하지만, 본 출원발명에서 사용되는 다른 소재들이 포함되어 있지 않고 또한 손소독제로서의 기능성에 대해서는 파악할 수 없다고 하겠다.In summary, the prior art documents are similar in that they are external preparations based on Hwangryeonhaedoktang as in the present application, but other materials used in the present application do not include other materials, and the functionality as a hand sanitizer cannot be grasped. .
해결과제는, 손소독제로 사용하기 위하여 항균 및 보습 효과를 보유한 가미황련해독탕을 안출하고 이를 유효성분으로 포함하는 손소독제 조성물을 제공하는 것이다.An object to be solved is to devise a Gamihwangryeon Haedok-tang having antibacterial and moisturizing effects for use as a hand sanitizer, and to provide a hand sanitizer composition comprising the same as an active ingredient.
해결수단은, 황금, 황련, 황백, 치자, 금은화, 연교, 청향 및 팔각회향의 혼합 추출물을 유효성분으로 함유하는 손소독제 조성물이다.The solution is a hand sanitizer composition containing as an active ingredient a mixed extract of gold, hwangryeon, hwangbaek, gardenia, geumgeumhwa, yeonkyo, cheonghyang and octagonal fennel.
상기 혼합 추출물에서, 황금, 황련, 황백, 치자, 금은화, 연교, 청향 및 팔각회향은 동일 중량으로 혼합되는 것을 특징으로 한다.In the mixed extract, gold, hwangryeon, hwangbaek, gardenia, geumgeumhwa, yeonkyo, cheonghyang and octagonal fennel are mixed by the same weight.
상기 조성물은 대장균, 황색포도상구균 및 Phi6 바이러스에 대한 항균 효능 및 보습 효능을 보유하는 것을 특징으로 한다.The composition is characterized in that it has antibacterial and moisturizing effects against E. coli, Staphylococcus aureus and Phi6 virus.
해결수단은, 황금, 황련, 황백, 치자, 금은화, 연교, 청향 및 팔각회향의 혼합 추출물을 유효성분으로 함유하는 손소독제 조성물을 포함하는 손소독제이다.The solution is a hand sanitizer comprising a hand sanitizer composition containing as an active ingredient a mixed extract of gold, hwangryeon, hwangbaek, gardenia, gold leaf, yeonkyo, cheonghyang and octagonal fennel.
본 발명에 따르는 조성물은 대장균, 황색포도상구균 및 Phi6 바이러스에 대한 항균 효능 및 보습 효능을 보유하고 있다.The composition according to the present invention has antibacterial and moisturizing effects against E. coli, Staphylococcus aureus and Phi6 virus.
도 1 내지 6은 실험예 1에 따른 실험결과를 나타내는 그래프 및 사진이다. 1 to 6 are graphs and photographs showing experimental results according to Experimental Example 1.
본 발명의 특징과 장점은 첨부된 도면에 의하여 설명되는 실험예 및 실시예에 의하여 보다 명확하게 이해될 수 있을 것이다.The features and advantages of the present invention will be more clearly understood by the experimental examples and examples described by the accompanying drawings.
본 발명의 실험예 및 실시예에 기재되거나 도면에 도시된 구성요소들의 구성 및 배열에 의해 본 발명의 응용이 제한되는 것이 아니다. 본 발명은 다른 실시예 들로 구현될 수 있고, 다양한 방법으로 수행될 수 있다. 또한 장치 또는 요소의 방향 등과 같은 용어들에 관하여 실시예에 사용된 표현 및 술어는 단지 본 발명의 설명을 단순화하기 위해 사용되며, 관련된 장치 또는 요소가 단순히 특정 방향을 가져야 함을 나타내거나 의미하지 않는다. 예를 들면, "제1", "제2"와 같은 용어가 본 발명을 설명하는 실시예와 청구항에 사용되는 경우, 이러한 용어가 상대적인 중요성 또는 취지를 나타내거나 의미하는 것으로 의도되지 않는다.The application of the present invention is not limited by the configuration and arrangement of the components described in the experimental examples and embodiments of the present invention or shown in the drawings. The present invention is capable of being embodied in other embodiments and of being carried out in various ways. Also, the expressions and predicates used in the embodiments with respect to terms such as the orientation of devices or elements are used only to simplify the description of the present invention, and do not indicate or imply that the related devices or elements simply have to have a specific orientation. . For example, where terms such as “first” and “second” are used in the embodiments and claims describing the present invention, they are not intended to indicate or imply relative importance or spirit.
또한, 본 명세서 및 청구범위에 사용된 용어나 단어는 통상적이거나 사전적인 의미로 한정하여 해석되어서는 아니되며, 발명자가 발명의 용어와 개념을 가장 최선의 방법으로 설명하기 위하여 본 발명의 기술적 사상에 부합하는 의미와 개념에 입각하여 기재한 것으로 해석하여야 한다.In addition, the terms or words used in the present specification and claims are not to be construed as being limited to conventional or dictionary meanings, and the inventors are in the technical spirit of the present invention in order to explain the terms and concepts of the invention in the best way. It should be interpreted as written based on the corresponding meaning and concept.
따라서, 본 발명은 제시되는 실시예에 한정되지 않으며, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의하여 본 발명의 기술 사상과 아래에 기재될 특허청구범위에 기재된 기술사상의 균등한 범위 내에서 다양한 수정 및 변경이 가능하다.Accordingly, the present invention is not limited to the embodiments presented, and equivalent scope of the technical spirit of the present invention and the technical spirit described in the claims to be described below by those of ordinary skill in the technical field to which the present invention belongs Various modifications and changes are possible within.
제조예 1. 가미황련해독탕 유효성분 시료 제조Preparation Example 1. Preparation of active ingredient samples of Gamihwangryeon Haedoktang
본 발명에 따른 가미황련해독탕 유효성분은 황금, 황련, 황백, 치자, 금은화, 연교, 청향 및 팔각회향을 포함한다. 하기의 표 1에는 유효성분에 포함된 소재들에 포함된 물질과 그 효능에 대하여 정리되어 있다.The active ingredient of Gamihwangryeonhaedoktang according to the present invention includes gold, hwangryeon, hwangbaek, gardenia, goldfinch, yeonkyo, cheonghyang and octagonal fennel. Table 1 below summarizes the substances contained in the materials included in the active ingredients and their efficacy.
(ScutellariaeRadix)Gold
(ScutellariaeRadix)
해열(解熱),항균(抗菌),
항Virus,항진균(抗眞菌),진정(鎭靜)detoxification,
Antipyretic, antibacterial,
Antivirus, antifungal, sedative
(Phellodendri Cortex)yellowish white
(Phellodendri Cortex)
(Gardeniae Fructus)gardenia
(Gardeniae Fructus)
(Caprifoliaceae)gold coin
(Caprifoliaceae)
(Oleaceae)annual school
(Oleaceae)
열매Uiseong Forsythia
Fruit
(Saururaceae)cloves
(Saururaceae)
(Boraginaceae)octagonal fennel
(Boraginaceae)
상기의 소재 8가지를 동일한 중량 비율(1:1)로 처방을 구성하여 3시간동안 증류 추출하였다. 이 증류 추출액을 시료로 사용하였다. (시료 농도 100ul/mL, 실험예 1에 적용)Eight materials above were formulated with the same weight ratio (1:1) and distilled and extracted for 3 hours. This distillation extract was used as a sample. (Sample concentration 100ul/mL, applied to Experimental Example 1)
실험예 1. 항균, Phi6 항바이러스 및 보습 분석Experimental Example 1. Antibacterial, Phi6 antiviral and moisturizing analysis
[실험방법][Test method]
1) 항균능력 분석 : E. coli ATCC10536 및 S. aureus ATCC6538 균주를 LB 액체배지에서 전배양한 후, 신선한 5 m LB 액체배지에 1/100로 접종하여 37℃에서 16시간 진탕배양 하였다. 배양된 균액은 원액 또는 1/10로 희석하여 균 희석액으로 사용하였다. 항균능력 분석은 식의약안전처 살균소독력시험법 중 중화희석시험법을 약간 변형하여 수행하였다.1) Antibacterial ability analysis: E. coli ATCC10536 and S. aureus ATCC6538 strains were pre-cultured in LB broth, inoculated at 1/100 in fresh 5 m LB broth, and cultured with shaking at 37°C for 16 hours. The cultured bacterial solution was diluted to a stock solution or 1/10 and used as a bacterial dilution solution. The antibacterial ability analysis was performed by slightly modifying the neutralization dilution test method among the sterilization and disinfection power test methods of the Ministry of Food and Drug Safety.
2) Phi6 시료 제조2) Phi6 sample preparation
Bacteriophage phi6는 Pseudomonas sp에 감염시킨 후 원심분리하여 상등액을 수거하였다. 수거된 상등액은 0.2 um 필터로 제균하였다. Phi6의 확인은 chloroform에 혼합한 후, phage plaque가 형성되는지 유무에 의해 판별하였다. Phi6 stock은 ~1010 PFU (plaque forming unit)/ml을 유지하였다. Bacteriophage phi6 was infected with Pseudomonas sp and then centrifuged to collect the supernatant. The collected supernatant was sterilized with a 0.2 um filter. Confirmation of Phi6 was determined by whether phage plaques were formed after mixing with chloroform. The Phi6 stock was maintained at ~1010 PFU (plaque forming unit)/ml.
3) 항바이러스 능력 분석3) Antiviral ability analysis
가미황련해독탕 시료를 phi6와 동량으로 혼합한 후, 5~30분간 20℃에서 반응하였다. 반응물은 연속적으로 10배씩 희석하여 이미 Top agar에 lawn으로 굳혀진 한천배지위에 일정량을 점적한 후 25℃에서 배양하였다. 배양 24~48시간 동안 Phi6 plaque를 관찰한 후, antivirus 활성을 분석하였다.A sample of Gamihwangryeon Haedoktang was mixed with phi6 in the same amount, and then reacted at 20°C for 5 to 30 minutes. The reactants were serially diluted 10-fold, and a certain amount was dripped onto the agar medium that had already been hardened with a lawn on the top agar, and then incubated at 25°C. After observing Phi6 plaques for 24 to 48 hours in culture, antivirus activity was analyzed.
[실험결과][Experiment result]
1) 항균능력 분석1) Antibacterial ability analysis
식약처 중화희석법에 따른 시험결과 감지수준인 103 CFU/ml 이하로 가미황련해독탕 소독제에서 감소되는 결과로 나타났다. 이 결과는 적어도 99.999% 이상의 항균 활성이 존재하는 것으로 추정된다. (도 1 참조, 생균수 참조)As a result of testing according to the Ministry of Food and Drug Safety's neutralization dilution method, it was found that the Gamihwangryeon Haedok-tang disinfectant decreased below the detection level of 103 CFU/ml. This result is estimated that at least 99.999% or more of the antibacterial activity is present. (See Fig. 1, see the number of viable cells)
2) 대장균 및 황색포도상구균 항균 분석2) E. coli and Staphylococcus aureus antibacterial analysis
시료 투입 전 OH의 사진 도 2와 시료 투입 후 5MIN 후의 사진 도 3을 살펴보면, 대장균에 대한 항균 능력이 확인될 수 있다. 또한, 시료 투입 전 OH의 사진 도 4와 시료 투입 후 5MIN 후의 사진 도 5를 살펴보면, 황색포도상구균에 대한 항균 능력이 확인될 수 있다. (대장균, 황색포도상구균 8.8x106 CFU/mL)Referring to FIG. 2 of the OH photo before the sample input and FIG. 3 after the sample input 5MIN, the antibacterial ability against E. coli can be confirmed. In addition, looking at Figure 4 of the OH before the sample input and Figure 5 after the sample input 5MIN, the antibacterial ability against Staphylococcus aureus can be confirmed. (E. coli, Staphylococcus aureus 8.8x10 6 CFU/mL)
3) Phi6 항바이러스 활성 분석3) Phi6 antiviral activity assay
Phi6 바이러스는 인플루엔자, 코로나바이러스와 같이 지질성분으로 둘러싸인 RNA 바이러스로 독감, 사스, 메르스, 코로나바이러스의 감염 연구 모델로 이용되는 바이러스이다.Phi6 virus is an RNA virus surrounded by lipid components, such as influenza and coronavirus, and is a virus used as an infection research model for influenza, SARS, MERS, and coronavirus.
가미황련해독탕 소독제에 대한 phi6 항바이러스 효과는 도 6에서 보는 바와 같이 5분 이상 처리시 99.991% 이상의 활성을 보였고, 30분 이상 처리시 99.999% 이상의 활성이 관찰되었다. (도6, 감염 phage개수 참조 As shown in FIG. 6 , the antiviral effect of phi6 on the Gamihwangryeonhaedoktang disinfectant was 99.991% or higher when treated for 5 minutes or longer, and 99.999% or higher activity was observed when treated for 30 minutes or longer. (See Figure 6, the number of infected phages.
4) 보습효과 분석4) Moisturizing effect analysis
아토피 피부의 주 원인인 건조증에 대한 개선효과로서 추출물 각각에 대해 보습효과 실험을 진행하였다. 완전 건조된 CaCl2를 흡습제로 사용하여 데시케이터 안에 담고 디쉬에 상기 추출물들을 각각 4g씩 저울에 달아 상대습도 50%, 35℃의 데시케이터에서 12시간 동안 각시료의 무게를 3회 측정하였다. 그 결과 가미황련해독탕 소독제가 보습효과가 우수한 것으로 나타났다.As an improvement effect on dryness, which is the main cause of atopic skin, a moisturizing effect test was conducted for each extract. Completely dried CaCl2 was used as a desiccant in a desiccator, and 4 g of each of the extracts were weighed on a scale on a dish, and the weight of each sample was measured three times in a desiccator at 50% relative humidity and 35° C. for 12 hours. As a result, it was found that the Gamihwangryeon Haedok-tang disinfectant had an excellent moisturizing effect.
실시예 1. 항균 및 보습 효과를 보유한 가미황련해독탕을 유효성분으로 포함하는 손소독제 조성물Example 1. Hand sanitizer composition comprising Gamihwangryeon Haedoktang with antibacterial and moisturizing effects as an active ingredient
본 발명에 따르는 상기 제조예 1에 기재된 가미황련해독탕을 유효성분으로 포함한다. 본 발명에 따르는 조성물은 유효성분 이외에 알코올을 포함할 수 있다. 또한 손소독제에 사용될 수 있는 약제학적으로 허용된 물질을 추가로 포함할 수 있다. According to the present invention, it contains the Gamihwangryeon Haedoktang described in Preparation Example 1 as an active ingredient. The composition according to the present invention may include alcohol in addition to the active ingredient. In addition, it may further include a pharmaceutically acceptable substance that can be used in hand sanitizer.
지금까지 본 발명에 대하여 바람직한 실시예를 중심으로 살펴보았다.So far, the present invention has been focused on preferred embodiments.
본 명세서에 기재된 실시예와 도면에 도시된 구성은 본 발명의 가장 바람직한 하나의 실시예에 관련된 것이고, 본 발명의 기술적 사상을 모두 대변하는 것은 아니므로, 이들을 대체할 수 있는 다양한 균등물과 변형된 예들이 있을 수 있음을 이해하여야 한다.The embodiments described in this specification and the configurations shown in the drawings relate to one most preferred embodiment of the present invention, and do not represent all of the technical spirit of the present invention, so various equivalents and modifications that can be substituted for them are It should be understood that there may be examples.
따라서 본 발명은 제시되는 실시예에 한정되지 않으며, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의하여 본 발명의 기술 사상과 아래에 기재될 특허청구범위에 기재된 기술사상의 균등한 범위 내에서 다양한 수정 및 변경이 가능한 실시예가 있을 수 있다.Therefore, the present invention is not limited to the presented embodiment, and within the equivalent scope of the technical spirit of the present invention and the technical spirit described in the claims to be described below by those of ordinary skill in the technical field to which the present invention belongs. There may be embodiments in which various modifications and changes are possible.
Claims (4)
A hand sanitizer composition containing as an active ingredient a mixed extract of gold, yellow lily, hwangbaek, gardenia, gold ginseng, yeonkyo, cheonghyang and octagonal fennel.
상기 혼합 추출물에서, 황금, 황련, 황백, 치자, 금은화, 연교, 청향 및 팔각회향은 동일 중량으로 혼합되는 것을 특징으로 하는 손소독제 조성물.
The method according to claim 1,
In the mixed extract, gold, hwangryeon, hwangbaek, gardenia, geumgeumhwa, yeonkyo, cheonghyang and octagonal fennel are mixed by the same weight.
상기 조성물은 대장균, 황색포도상구균 및 Phi6 바이러스에 대한 항균 효능 및 보습 효능을 보유하는 것을 특징으로 하는 손소독제 조성물.
The method according to claim 1,
The composition is a hand sanitizer composition, characterized in that it has antibacterial and moisturizing effects against E. coli, Staphylococcus aureus and Phi6 virus.
A hand sanitizer comprising the composition according to claim 1.
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