KR102261636B9 - 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 - Google Patents

항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Info

Publication number
KR102261636B9
KR102261636B9 KR1020207012363A KR20207012363A KR102261636B9 KR 102261636 B9 KR102261636 B9 KR 102261636B9 KR 1020207012363 A KR1020207012363 A KR 1020207012363A KR 20207012363 A KR20207012363 A KR 20207012363A KR 102261636 B9 KR102261636 B9 KR 102261636B9
Authority
KR
South Korea
Prior art keywords
vegf
age
methods
macular degeneration
patients suffering
Prior art date
Application number
KR1020207012363A
Other languages
English (en)
Other versions
KR20200047779A (ko
KR102261636B1 (ko
Inventor
로라 퍼리
사라 하몬
찰스 폴딩
Original Assignee
리제너론 파마슈티칼스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57758695&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102261636(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 리제너론 파마슈티칼스 인코포레이티드 filed Critical 리제너론 파마슈티칼스 인코포레이티드
Priority to KR1020217016566A priority Critical patent/KR102343004B1/ko
Publication of KR20200047779A publication Critical patent/KR20200047779A/ko
Application granted granted Critical
Publication of KR102261636B1 publication Critical patent/KR102261636B1/ko
Publication of KR102261636B9 publication Critical patent/KR102261636B9/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Data Mining & Analysis (AREA)
  • Primary Health Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
KR1020207012363A 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 KR102261636B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562262589P 2015-12-03 2015-12-03
US62/262,589 2015-12-03
US201662291274P 2016-02-04 2016-02-04
US62/291,274 2016-02-04
PCT/US2016/064403 WO2017096031A1 (en) 2015-12-03 2016-12-01 Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-vegf
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187017681A Division KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217016566A Division KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Publications (3)

Publication Number Publication Date
KR20200047779A KR20200047779A (ko) 2020-05-07
KR102261636B1 KR102261636B1 (ko) 2021-06-07
KR102261636B9 true KR102261636B9 (ko) 2023-07-13

Family

ID=57758695

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020207012363A KR102261636B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020217041649A KR20210157427A (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020217041649A KR20210157427A (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Country Status (21)

Country Link
US (2) US11769597B2 (ko)
EP (2) EP4276199A3 (ko)
JP (4) JP6855480B2 (ko)
KR (4) KR102343004B1 (ko)
CN (2) CN114712497B (ko)
AU (4) AU2016364817B2 (ko)
CA (3) CA3007276C (ko)
DK (1) DK3384049T3 (ko)
ES (1) ES2956007T3 (ko)
FI (1) FI3384049T3 (ko)
HR (1) HRP20231379T1 (ko)
HU (1) HUE063335T2 (ko)
IL (3) IL302424A (ko)
LT (1) LT3384049T (ko)
MX (3) MX2018006740A (ko)
NZ (1) NZ744025A (ko)
PL (1) PL3384049T3 (ko)
PT (1) PT3384049T (ko)
RS (1) RS64725B1 (ko)
SI (1) SI3384049T1 (ko)
WO (1) WO2017096031A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
HRP20231379T1 (hr) 2015-12-03 2024-02-16 Regeneron Pharmaceuticals, Inc. Postupci dovođenja u vezu genskih varijanti s kliničkim ishodom kod pacijenata koji pate od starosne makularne degeneracije liječenih anti-vegf-om
CN108712911A (zh) 2015-12-30 2018-10-26 科达制药股份有限公司 抗体及其缀合物
GB201805642D0 (en) * 2018-04-05 2018-05-23 Macusoft Ltd Determining a clinical outcome for a subject suffering from a macular degenerative disease
CN109632924B (zh) * 2018-12-17 2022-02-08 上海市第一人民医院 人黄斑新生血管性疾病的血浆脂质标记物及其应用
JP2022553640A (ja) 2019-10-10 2022-12-26 コディアック サイエンシーズ インコーポレイテッド 眼障害を処置する方法
KR102625384B1 (ko) 2020-09-28 2024-01-16 (주) 플라즈닉스 플라즈마 토치 및 이를 이용하여 대상기체를 처리하는 방법

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011298A1 (en) 1988-05-27 1989-11-30 Centocor, Inc. Formulation for antibody reagents
DE4243524A1 (de) 1992-12-22 1994-06-23 Hoechst Ag Gemische isomerer Nonanole und Decanole, ihre Herstellung, aus ihnen erhältliche Phthalsäureester und deren Verwendung als Weichmacher
CN102416176A (zh) 1995-07-27 2012-04-18 基因技术股份有限公司 稳定等渗的冻干蛋白质制剂
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
DE19622283A1 (de) 1996-05-23 1997-11-27 Schering Ag Verfahren zur terminalen Sterilisierung von befüllten Spritzen
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
PT1325932E (pt) 1997-04-07 2005-06-30 Genentech Inc Anticorpos anti-vegf
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
DE19849922A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Behandlung von Basen und organische Säuren enthaltenden wäßrigen Lösungen
DE19849924A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Abtrennung organischer Säuren aus wäßrigen Lösungen
US6455743B1 (en) 1998-11-27 2002-09-24 Mitsubishi Chemical Corporation Process for producing alcohols
DE19914259A1 (de) 1999-03-29 2000-10-05 Basf Ag Verfahren zur destillativen Auftrennung eines flüssigen Rohaldehydgemisches
JP4926320B2 (ja) 1999-04-28 2012-05-09 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｖｅｇｆの選択的阻害による癌処置のための組成物および方法
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
ES2319305T3 (es) 1999-06-08 2009-05-06 Regeneron Pharmaceuticals, Inc. Quimeras del receptor del vegf para el tratamiento de trastornos oculares caracterizados por la permeabilidad vascular.
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
DE19933348B4 (de) 1999-07-16 2005-11-17 Oxeno Olefinchemie Gmbh Verfahren zur Reduzierung oxidischer Hydrierkontakte
US6777429B1 (en) 1999-07-23 2004-08-17 Novartis Ag Ophthalmic composition
DE19957522A1 (de) 1999-11-30 2001-05-31 Oxeno Olefinchemie Gmbh Verfahren zur katalytischen Durchführung von Aldolkondensationen mittels Mehrphasenreaktion
DE10103706A1 (de) 2001-01-26 2002-08-14 Aventis Behring Gmbh Verwendung eines Hydrogenperoxid-Plasma-Sterilisationsverfahrens für die schonende Sterilisation temperaturempfindlicher Produkte
CA2452372A1 (en) 2001-07-06 2003-01-16 Sucampo Ag Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
CA2454587C (en) 2001-07-25 2012-11-13 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
JP5290489B2 (ja) 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｉｇｇ抗体の安定な液体医薬製剤
IL161327A0 (en) 2001-11-09 2004-09-27 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
JP4141156B2 (ja) 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
CN1798575A (zh) 2003-04-04 2006-07-05 健泰科生物技术公司 高浓度抗体和蛋白制剂
EP1626989A2 (en) 2003-05-28 2006-02-22 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
CA2519875C (en) 2003-06-06 2014-01-14 Regeneron Pharmaceuticals, Inc. Method of tumor regression with vegf inhibitors
US20050112061A1 (en) 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
CN1997386B (zh) 2004-07-30 2012-05-30 瑞泽恩制药公司 通过阻断vegf介导的活性来治疗i型糖尿病的方法
EP2319492A3 (en) 2004-10-21 2011-08-10 Genentech, Inc. Method for treating intraocular neovascular diseases
WO2006062716A2 (en) * 2004-11-18 2006-06-15 Yale University Methods and compositions for treating ocular disorders
US7303748B2 (en) 2005-02-02 2007-12-04 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a VEGF inhibitor
CN101141975B (zh) 2005-03-25 2012-05-23 瑞泽恩制药公司 Vegf拮抗剂制剂
EP1917024A2 (en) 2005-08-12 2008-05-07 Regeneron Pharmaceuticals, Inc. Methods of treating diseases with a vegf antagonist
WO2007035621A1 (en) 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
ATE406926T1 (de) 2006-02-14 2008-09-15 Gerresheimer Buende Gmbh Verfahren zum herstellen von vorfüllbaren spritzen
KR101406811B1 (ko) 2006-06-16 2014-06-12 리제너론 파마슈티칼스 인코포레이티드 유리체내 투여에 적당한 ｖｅｇｆ 길항제 제형
US20100111963A1 (en) 2006-11-10 2010-05-06 Genentech, Inc. Method for treating age-related macular degeneration
CA2670935A1 (en) 2006-11-30 2008-06-05 Basf Se Process for the hydroformylation of olefins
WO2008077155A1 (en) 2006-12-21 2008-06-26 Genentech, Inc. Sterilization of objects containing biological molecules
KR20100037590A (ko) * 2007-06-08 2010-04-09 바이오겐 아이덱 엠에이 인코포레이티드 항 ｔｎｆ 반응 또는 무반응을 예측하기 위한 바이오마커
WO2009030976A1 (en) 2007-09-03 2009-03-12 Becton Dickinson France Medical device and smooth coating therefor
TWI543790B (zh) 2008-12-03 2016-08-01 Denka Company Ltd syringe
ES2600781T3 (es) * 2008-12-04 2017-02-10 Curna, Inc. Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
DE102009001594A1 (de) 2009-03-17 2010-09-30 Evonik Oxeno Gmbh Verfahren zur Herstellung von alpha, beta-ungesättigten C10-Aldehyden
EP2409746A4 (en) 2009-03-19 2012-05-30 Lg Chemical Ltd DISTILLATION COLUMN WITH SEPARATION WALL FOR THE PRODUCTION OF HIGH-PURITY 2-ETHYLHEXANOL AND FRACTIONATION METHOD USING THESE COLUMNS
AR078060A1 (es) 2009-07-14 2011-10-12 Novartis Ag Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
DE102009045139A1 (de) 2009-09-30 2011-03-31 Evonik Oxeno Gmbh Herstellung von alpha,beta-ungesättigten Aldehyden mittels einer Reaktionsmischpumpe
DE102009045718A1 (de) 2009-10-15 2011-04-21 Evonik Oxeno Gmbh Verfahren zur Herstellung von Decanolen durch Hydrierung von Decenalen
LT2491134T (lt) 2009-10-21 2017-10-10 Genentech, Inc. Genetiniai polimorfizmai, esant geltonosios dėmės su amžiumi susietai degeneracijai
EP2547642B1 (en) 2010-03-15 2016-01-13 ExxonMobil Chemical Patents Inc. Processes for the production of alcohols
FR2966044B1 (fr) 2010-10-18 2012-11-02 Sanofi Pasteur Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium
US8684190B2 (en) 2010-11-19 2014-04-01 Warren Abar Multi-position solar panel rack
KR20210030510A (ko) 2011-01-13 2021-03-17 리제너론 파아마슈티컬스, 인크. 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
EP2686007B1 (en) * 2011-03-15 2019-04-24 University of Utah Research Foundation Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
KR20140114415A (ko) * 2012-01-13 2014-09-26 제넨테크, 인크. Vegf 길항제로의 치료를 위한 환자를 확인하기 위한 생물학적 마커
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
KR20140042402A (ko) 2012-09-28 2014-04-07 주식회사 엘지화학 올레핀으로부터 알코올의 제조장치 및 제조방법
JP5721150B2 (ja) * 2013-03-14 2015-05-20 学校法人 埼玉医科大学 加齢黄斑変性症の発症リスクの予測方法
WO2014178031A1 (en) 2013-05-03 2014-11-06 Saudi Basic Industries Corporation Integrated process for simultaneous production of oxo-alcohols and plasticizers
EP3628373A1 (en) 2013-07-12 2020-04-01 IVERIC bio, Inc. Methods for treating or preventing opthalmological conditions
WO2015012332A1 (ja) 2013-07-24 2015-01-29 田辺三菱製薬株式会社 眼科疾患治療剤
DE102014201756A1 (de) 2014-01-31 2015-08-06 Evonik Degussa Gmbh Reinigung chlorverschmutzter Organophosphorverbindungen
DE102014209536A1 (de) 2014-05-20 2015-11-26 Evonik Degussa Gmbh Herstellung qualitativ hochwertiger Oxo-Alkohole aus unsteten Rohstoffquellen
PT3037400T (pt) 2014-12-23 2018-10-23 Evonik Degussa Gmbh Hidrogenação livre de cromo de misturas de hidroformilação
US10155200B2 (en) 2015-02-18 2018-12-18 Evonik Degussa Gmbh Separation off of a homogeneous catalyst from a reaction mixture with the help of organophilic nanofiltration
SG10201601501QA (en) 2015-03-05 2016-10-28 Evonik Degussa Gmbh Preparation of 2,2`-biaryls in the presence of molybdenum(v) chloride
CN104894261B (zh) * 2015-06-02 2020-02-14 北京医院 一种预测雷珠单抗治疗年龄相关性黄斑变性疗效的试剂盒
CN108350010B (zh) 2015-11-09 2020-09-04 赢创运营有限公司 2-丙基庚醇的经济制备
ES2701843T3 (es) 2015-11-19 2019-02-26 Evonik Degussa Gmbh Influencia de la viscosidad de mezclas de ésteres basadas en n-buteno mediante empleo selectivo de eteno en la obtención de productos previos de ésteres
HRP20231379T1 (hr) 2015-12-03 2024-02-16 Regeneron Pharmaceuticals, Inc. Postupci dovođenja u vezu genskih varijanti s kliničkim ishodom kod pacijenata koji pate od starosne makularne degeneracije liječenih anti-vegf-om
PL3246303T3 (pl) 2016-05-19 2020-06-01 Evonik Operations Gmbh Wytwarzanie n-pentanalu z mieszanin surowców ubogich w buten
US10245578B2 (en) 2016-11-09 2019-04-02 Evonik Degussa Gmbh Chromium- and nickel-free hydrogenation of hydroformylation mixtures
RS61247B1 (sr) 2017-01-20 2021-01-29 Evonik Operations Gmbh Diizopentiltereftalat
IL274711B1 (en) 2017-11-30 2024-06-01 Regeneron Pharma Use of VEGF antagonist to treat angiogenic eye disorders

Also Published As

Publication number Publication date
MX2023008504A (es) 2023-07-26
EP4276199A3 (en) 2024-04-10
AU2016364817B2 (en) 2020-05-07
CA3137326A1 (en) 2017-06-08
MX2018006740A (es) 2018-08-01
MX2023004922A (es) 2023-05-16
HRP20231379T1 (hr) 2024-02-16
HUE063335T2 (hu) 2024-01-28
IL259672A (en) 2018-07-31
KR102343004B9 (ko) 2023-07-13
EP4276199A2 (en) 2023-11-15
IL295808A (en) 2022-10-01
EP3384049B1 (en) 2023-08-02
IL259672B (en) 2022-10-01
US20180276336A1 (en) 2018-09-27
LT3384049T (lt) 2023-09-11
IL295808B1 (en) 2023-06-01
JP7429318B2 (ja) 2024-02-07
ES2956007T3 (es) 2023-12-11
KR20210068154A (ko) 2021-06-08
KR20180081616A (ko) 2018-07-16
PT3384049T (pt) 2023-08-18
JP2023053348A (ja) 2023-04-12
RS64725B1 (sr) 2023-11-30
IL302424A (en) 2023-06-01
CA3137326C (en) 2024-01-23
WO2017096031A1 (en) 2017-06-08
DK3384049T3 (da) 2023-10-02
AU2016364817A1 (en) 2018-07-19
CN108474039B (zh) 2022-06-07
JP6855480B2 (ja) 2021-04-07
FI3384049T3 (fi) 2023-09-25
JP2019503665A (ja) 2019-02-14
EP3384049A1 (en) 2018-10-10
AU2022235531A1 (en) 2022-10-13
CN114712497B (zh) 2024-03-22
NZ744025A (en) 2020-02-28
JP2021091737A (ja) 2021-06-17
CN108474039A (zh) 2018-08-31
KR20200047779A (ko) 2020-05-07
KR102261636B1 (ko) 2021-06-07
KR102343004B1 (ko) 2021-12-24
AU2020203362A1 (en) 2020-06-11
AU2022235529A1 (en) 2022-10-13
JP2024028658A (ja) 2024-03-04
AU2020203362B2 (en) 2022-07-14
CA3179836A1 (en) 2017-06-08
PL3384049T3 (pl) 2024-01-22
CA3007276A1 (en) 2017-06-08
CA3007276C (en) 2021-12-28
IL295808B2 (en) 2023-10-01
CN114712497A (zh) 2022-07-08
JP7233754B2 (ja) 2023-03-07
IL259672B2 (en) 2023-02-01
SI3384049T1 (sl) 2023-10-30
KR20210157427A (ko) 2021-12-28
KR102183910B1 (ko) 2020-11-27
US11769597B2 (en) 2023-09-26
KR102183910B9 (ko) 2023-07-13
US20240029897A1 (en) 2024-01-25

Similar Documents

Publication Publication Date Title
IL295808A (en) Methods for associating genetic variants with clinical outcome in patients suffering from age-related macular degeneration and receiving treatment against tubular endothelial growth factor
HRP20190117T1 (hr) iRNK TERAPIJA ZA LIJEČENJE BOLESTI OKA
HK1246179A1 (zh) 治療視網膜疾病的方法
EP3458585A4 (en) GENE THERAPY PROCEDURES FOR AGE-RELATED ILLNESSES AND SUFFERING
SG11201706755SA (en) Methods and compositions for treating genetic eye diseases
GB201403260D0 (en) Treatment of retinal degeneration using gene therapy
HK1258518A1 (zh) 用於眼病的基因療法
SG11201704668PA (en) Treatment of retinal degeneration using progenitor cells
IL261292A (en) Gene therapy for the treatment of retinal degeneration
HK1253299A1 (zh) 一種通過基因治療治療眼疾病的改進方法
SG11201702132WA (en) A method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases
IL261295A (en) Gene therapy for the treatment of retinal cone cell disease
GB201412578D0 (en) Treatment of neurological diseases
IL259381B (en) Miravegron for the treatment of retinal diseases
PL3302463T3 (pl) Zastosowanie 3 deoksyantocyjanidyn w leczeniu chorób oczu
PT2777699T (pt) Dietilamina-2,5-di-hidroxibenzenossulfonato para o tratamento de degeneração macular relacionada com a idade
GB201517565D0 (en) Treatment of genetic diseases
GB201604253D0 (en) Treatment of genetic diseases

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
X091 Application refused [patent]
AMND Amendment
X701 Decision to grant (after re-examination)
A107 Divisional application of patent
GRNT Written decision to grant
G170 Re-publication after modification of scope of protection [patent]