JP6855480B2 - 抗vegfで処置された加齢黄斑変性症に罹患している患者の臨床転帰に遺伝変異型を関連付ける方法 - Google Patents
抗vegfで処置された加齢黄斑変性症に罹患している患者の臨床転帰に遺伝変異型を関連付ける方法 Download PDFInfo
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Description
本願は、2015年12月3日に出願された米国仮特許出願第62/262,589号及び2106年2月4日に出願された米国仮特許出願第60/291,274号の利益を主張するものであり、本願において参照によりそれらの両方の内容全体を本明細書に援用する。
開示される方法及び構成物は、特定の実施形態及びその中に含まれる実施例についての以下の詳細な説明と、図面ならびにそれらの上記及び下記の記載を参照することによってより容易に理解され得る。
本明細書及び別記の特許請求の範囲において使用する場合、単数形「a」、「an」及び「the」は、文脈から明確に別段の定めがなされない限り、複数形への言及を包含する。したがって、例えば、「医薬担体」への言及は2つ以上のそのような担体の混合物などを包含する。
本明細書では、視力、解剖学的転帰または処置頻度に遺伝子変異型を関連付ける方法であって、(a)(i)硝子体内用抗VEGF剤を投与された新生血管加齢黄斑変性症対象の集団の1つ以上の遺伝子変異型を、(ii)新生血管加齢黄斑変性症対象の上記集団の解剖学的転帰に、統計学的に関連付けることを含み、1つ以上の遺伝子変異型が、1年間の処置の後での網膜内嚢胞様浮腫(液)の欠如と比べた場合の、網膜内嚢胞様浮腫(液)の存在と関連付けられる、当該方法を開示する。
さらに、本明細書に記載の方法を利用するためのキットが本明細書において記載される。本明細書に記載のキットは、対象の試料中の1つ以上の遺伝子変異型を検出するための1つ以上のアッセイを含むことができる。
Claims (9)
- 黄斑変性症患者の処置のための薬剤の製造における血管内皮成長因子(VEGF)阻害剤の使用であって、前記患者は、以前にVEGF阻害剤を約1年間投与されており、前記患者から得られるDNA試料で遺伝子型アッセイを行うか行ったことにより決定される1つ以上の遺伝子変異型を前記患者が有しており、前記1つ以上の遺伝子変異型は、rs2056688、rs5962084、rs5962087、rs5915722、rs5962095、rs2106124、rs1879796、rs12148845、rs12148100、rs17482885及びrs17629019から構成される群から選択される一塩基多型である、前記使用。
- 前記1つ以上の遺伝子変異型は、rs2056688、rs5962084、rs5962087、rs5915722及びrs5962095から構成される群から選択される一塩基多型である、請求項1に記載の使用。
- 前記1つ以上の遺伝子変異型は、rs2106124、rs1879796、rs12148845及びrs12148100から構成される群から選択される一塩基多型である、請求項1に記載の使用。
- 前記1つ以上の遺伝子変異型は、rs17482885及びrs17629019から構成される群から選択される一塩基多型である、請求項1に記載の使用。
- 前記患者は、前記1つ以上の遺伝子変異型についてヘテロ接合性である、請求項1に記載の使用。
- 前記患者は、前記1つ以上の遺伝子変異型についてホモ接合性である、請求項1に記載の使用。
- 前記遺伝子変異型がrs2056688である、請求項1に記載の使用。
- 前記VEGF阻害剤は、前記黄斑変性症患者の治療のために3ヶ月毎に約2mgの量である、請求項1〜4のいずれか一項に記載の使用。
- 前記VEGF阻害剤がアフリベルセプトである、請求項1〜5のいずれか一項に記載の使用。
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JP2021043218A Active JP7233754B2 (ja) | 2015-12-03 | 2021-03-17 | 抗vegfで処置された加齢黄斑変性症に罹患している患者の臨床転帰に遺伝変異型を関連付ける方法 |
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JP2023021608A Active JP7429318B2 (ja) | 2015-12-03 | 2023-02-15 | 抗vegfで処置された加齢黄斑変性症に罹患している患者の臨床転帰に遺伝変異型を関連付ける方法 |
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