KR100969402B1 - I형 글리신 수송 억제제로서의 비시클릭 [3.1.0]헤테로아릴 아미드 - Google Patents
I형 글리신 수송 억제제로서의 비시클릭 [3.1.0]헤테로아릴 아미드 Download PDFInfo
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Abstract
Description
Claims (17)
- 하기 화학식 I의 화합물, 또는 그의 제약학적으로 허용가능한 염 또는 용매화물.<화학식 I>상기 식에서,R1은 이미다졸릴, 티아졸릴, 피리딜, 옥사졸릴, 피라졸릴, 트리아졸릴, 옥사디아졸릴, 퀴놀리닐, 이속사졸릴, 피롤로이미다졸릴 및 티아디아졸로 이루어지는 군으로부터 선택되는 헤테로아릴을 나타내고, 여기서 상기 헤테로아릴은 -OH, -NR7R8, 할로겐, (C1-C8)알킬, (C3-C10)시클로알킬, (C1-C8)알콕시, (C1-C12)알콕시알킬, (C1-C8)히드록시알킬, (C6-C14)아릴 및 벤질로부터 선택되는 하나 이상의 치환기로 임의로 치환되고;R2, R3 및 A는 독립적으로 H 또는 (C1-C8)알킬을 나타내고, 여기서 상기 알킬은 하나 이상의 -OH, (C1-C8)알콕시, -NR7R8 또는 할로겐으로 임의로 치환되고;Q는 -(CH2)n- (여기서, n = 1, 2, 3 또는 4) 또는 -(CH2)m-O- (여기서, m = 2, 3 또는 4)를 나타내고;Z는 (C6-C14)아릴, (C1-C8)알킬 또는 (C3-C8)시클로알킬을 나타내고;R4 및 R5는 각각 독립적으로 H, 할로겐, (C1-C8)알킬, (C6-C14)아릴, (C6-C14)아릴옥시, (C1-C8)알콕시, (3-10원)헤테로시클로알킬 또는 (C3-C8)시클로알콕시를 나타내고; 여기서 R4 및 R5는 하나 이상의 -OH, (C1-C8)알콕시, -NR7R8 또는 할로겐으로 임의로 치환되고;Y는 -R6, -(CH2)o-R6, -C(R6)3 또는 -CH(R6)2를 나타내고, 여기서 o는 1, 2 또는 3이고;R6은 H, (C6-C14)아릴, (C1-C10)알킬, (C3-C10)시클로알킬, (C5-C18)비시클로알킬, (C5-C18)트리시클로알킬, (3-10원)헤테로시클로알킬, (5-10원)헤테로아릴, -C(=O)NR7R8 또는 -C(=O)OR7을 나타내고, 여기서 상기 R6 기는 하나 이상의 X기로 임의로 치환될 수 있고;여기서, X는 -OH, (C1-C8)알콕시, -NR11R12, -SO2R10, -C(=O)R10, 할로겐, 시아노, (C1-C8)알킬, (C1-C10)알콕시알킬, (5-10원)헤테로아릴, (C6-C14)아릴, (C6-C14)아릴옥시, 벤질 또는 (C1-C8)히드록시알킬이고;여기서, R7 및 R8은 독립적으로 H, (C1-C8)알킬, (C3-C8)시클로알킬, (5-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타내고; 여기서, R7 및 R8은 하나 이상의 X기로 임의로 치환될 수 있거나; 또는R7 및 R8은 이들이 부착될 수 있는 질소와 함께, 하나 이상의 X기로 임의로 치환되는 (3-10원)헤테로시클로알킬 기를 형성할 수 있고;여기서, R10은 (C1-C8)알킬, (C3-C8)시클로알킬, (3-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타내고;여기서, R11 및 R12는 독립적으로 H, (C1-C8)알킬, (C3-C8)시클로알킬, (5-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타낸다.
- 제1항에 있어서, Z가 (C6-C14)아릴이고, R4 또는 R5가 각각 독립적으로 H, 할로겐, -CF3, -OCF3, (C6-C14)아릴 또는 (C6-C14)아릴옥시인 화합물.
- 제1항에 있어서, R2, R3 및 A가 수소인 화합물.
- 제1항에 있어서, Y가 (C1-C6)알킬, (C3-C6)시클로알킬, (3-6원)헤테로시클로알킬 또는 -CH2-(C3-C6)시클로알킬이고; 여기서, Y는 할로겐, OH, -SO2R10, -C(=O)R10 또는 -CH2CH2CF3로 임의로 치환되는 화합물.
- 제3항에 있어서, R1이 이미다졸릴인 화합물.
- 하기 화학식의 화합물, 또는 그의 제약학적으로 허용가능한 염 또는 용매화물.R2, R3 및 A는 독립적으로 H 또는 (C1-C8)알킬을 나타내고, 여기서 상기 알킬은 하나 이상의 -OH, (C1-C8)알콕시, -NR7R8 또는 할로겐으로 임의로 치환되고;Q는 -(CH2)n- (여기서, n = 1, 2, 3 또는 4) 또는 -(CH2)m-O- (여기서, m = 2, 3 또는 4)를 나타내고;Z는 (C6-C14)아릴, (C1-C8)알킬 또는 (C3-C8)시클로알킬을 나타내고;R4 및 R5는 각각 독립적으로 H, 할로겐, (C1-C8)알킬, (C6-C14)아릴, (C6-C14)아릴옥시, (C1-C8)알콕시, (3-10원)헤테로시클로알킬 또는 (C3-C8)시클로알콕시를 나타내고; 여기서 R4 및 R5는 하나 이상의 -OH, (C1-C8)알콕시, -NR7R8 또는 할로겐으로 임의로 치환되고;Y는 -R6, -(CH2)o-R6, -C(R6)3 또는 -CH(R6)2를 나타내고, 여기서 o는 1, 2 또는 3이고;R6은 H, (C6-C14)아릴, (C1-C10)알킬, (C3-C10)시클로알킬, (C5-C18)비시클로알킬, (C5-C18)트리시클로알킬, (3-10원)헤테로시클로알킬, (5-10원)헤테로아릴, -C(=O)NR7R8 또는 -C(=O)OR7을 나타내고, 여기서 상기 R6 기는 하나 이상의 X기로 임의로 치환될 수 있고;여기서, X는 -OH, (C1-C8)알콕시, -NR11R12, -SO2R10, -C(=O)R10, 할로겐, 시아노, (C1-C8)알킬, (C1-C10)알콕시알킬, (5-10원)헤테로아릴, (C6-C14)아릴, (C6-C14)아릴옥시, 벤질 또는 (C1-C8)히드록시알킬이고;여기서, R7 및 R8은 독립적으로 H, (C1-C8)알킬, (C3-C8)시클로알킬, (5-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타내고; 여기서, R7 및 R8은 하나 이상의 X기로 임의로 치환될 수 있거나; 또는R7 및 R8은 이들이 부착될 수 있는 질소와 함께, 하나 이상의 X기로 임의로 치환되는 (3-10원)헤테로시클로알킬 기를 형성할 수 있고;여기서, R10은 (C1-C8)알킬, (C3-C8)시클로알킬, (3-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타내고;여기서, R11 및 R12는 독립적으로 H, (C1-C8)알킬, (C3-C8)시클로알킬, (5-10원)헤테로시클로알킬, (C1-C8)히드록시알킬, (5-10원)헤테로아릴 또는 (C1-C10)알콕시알킬을 나타낸다.
- 제7항에 있어서, Z가 (C6-C14)아릴이고, R4 또는 R5가 각각 독립적으로 H, 할로겐, -CF3, -OCF3, (C6-C14)아릴 또는 (C6-C14)아릴옥시인 화합물.
- 제7항에 있어서, R2, R3 및 A가 수소인 화합물.
- 제7항에 있어서, Y가 (C1-C6)알킬, (C3-C6)시클로알킬, (3-20원)헤테로시클로알킬 또는 -CH2-(C3-C6)시클로알킬이고, 여기서, Y는 할로겐, OH, -SO2R10, -C(=O)R10 또는 -CH2CH2CF3로 임의로 치환되는 화합물.
- 제1항에 있어서, 상기 화합물이1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-4-플루오로-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-이소프로폭시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로펜틸옥시-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2-디메틸-프로폭시)-4-플루오로-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로헥실옥시-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-1-트리플루오로메틸-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,5-디클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,5-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2,4-디클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2,4-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,4-디클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,4-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메탄술포닐-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-1-트리플루오로메틸-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로헥실메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(2-클로로-페닐)-2-히드록시-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로펜틸메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3,4-디클로로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3,4-디클로로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-플루오로-5-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2,3-디클로로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2,4-디클로로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-플루오로-5-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-페닐-프로필)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-페녹시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-비페닐-4-일메틸-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-페닐-부틸)-아미드;피리딘-2-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-비페닐-3-일메틸-아미드;피리딘-2-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;피리딘-2-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(5-플루오로-2-트리플루오로메틸-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;피리딘-2-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-플루오로-5-트리플루오로메틸-벤질)-아미드;피리딘-2-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-플루오로-5-트리플루오로메틸-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2-트리플루오로메틸-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[2-(4-클로로-페닐)-에틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[2-(3-트리플루오로메틸-페닐)-에틸]-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(2,4-디플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[2-(3-클로로-페닐)-에틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-이소부틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,2-디메틸-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(테트라히드로-푸란-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(테트라히드로-푸란-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-메틸-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3-메틸-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-이속사졸-3-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-메틸-펜틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-3-메틸-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로헥실메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3,3-디메틸-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-헵틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-1H-이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-비시클로[2.2.1]헵트-5-엔-2-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(5-메틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,4-디메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1,5-디메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-시아노-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;2-메틸-3-(6-{[(1-메틸-1H-이미다졸-4-카르보닐)-(3-트리플루오로메톡시-벤질)-아미노]-메틸}-3-아자-비시클로[3.1.0]헥스-3-일)-프로피온산 에틸 에스테르1-메틸-1H-이미다졸-4-카르복실산 (3-펜에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-에틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(6-옥소-1,6-디히드로-피리딘-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,5-디메틸-2H-피라졸-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-p-톨릴-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-5-메틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-5-메틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-에틸-헥실)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-에틸-3-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-에틸-3-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(5-메톡시메틸-푸란-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3-페닐-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3-플루오로-4-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-에틸-5-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,5-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-1-메틸-1H-피라졸-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-클로로-피리딘-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-벤조이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3,5-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-인돌-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-클로로-티아졸-5-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,3-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-인돌-5-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(3,5,5-트리메틸-헥실)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2,4-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-이소프로필-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-벤조[1,3]디옥솔-5-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-피리딘-2-일-1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-나프탈렌-2-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-벤조[1,3]디옥솔-4-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-피리미딘-2-일-1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-나프탈렌-1-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[3-(5-메틸-푸란-2-일)-부틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(6,6-디메틸-비시클로[3.1.1]헵트-2-엔-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-벤조티아졸-2-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-디플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(4-트리플루오로메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-비페닐-4-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(3-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(3-페닐-부틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(6-페녹시-피리딘-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-페녹시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(2-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(1-히드록시-시클로헥실메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(4-페녹시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 (3-펜에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[에틸-(2-히드록시-에틸)-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(sec-부틸-메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(1-메틸-1H-피라졸-3-일카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(시클로프로필메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(tert-부틸카르바모일-메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로부틸카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2-메톡시-에틸카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2-메톡시-1-메틸-에틸카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2-히드록시-프로필카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-페닐카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(1H-이미다졸-2-일카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(이소프로필카르바모일-메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2,2-디메틸-프로필카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(피리딘-3-일카르바모일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[메틸-(3-메틸-피리딘-2-일메틸)-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2-히드록시-1,1-디메틸-에틸카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(피리딘-2-일카르바모일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2-메틸-2H-피라졸-3-일카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(2,2,2-트리플루오로-에틸카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[(푸란-2-일메틸)-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-디메틸카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(1-메틸-1H-[1,2,4]트리아졸-3-일카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로헥실카르바모일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-옥소-2-피롤리딘-1-일-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(2-메틸-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-옥소-2-피페리딘-1-일-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(시클로프로필메틸-메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-모르폴린-4-일-2-옥소-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-히드록시-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-히드록시-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-히드록시-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(에틸-이소프로필-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(카르바모일메틸-메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-메틸-피페리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(4-메틸-피페리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-옥소-2-티아졸리딘-3-일-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-히드록시메틸-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(2-히드록시메틸-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3-히드록시-피페리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-옥소-2-티오모르폴린-4-일-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(2,6-디메틸-모르폴린-4-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(메틸-티오펜-2-일메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(푸란-2-일메틸-메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(벤질-메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(1,3-디히드로-이소인돌-2-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(3,4-디플루오로-피롤리딘-1-일)-2-옥소-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[메틸-(2,2,2-트리플루오로-에틸)-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(메틸-티오펜-3-일메틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[(메틸-펜에틸-카르바모일)-메틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[메틸-(1-피리딘-4-일-에틸)-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-옥소-2-(3-페닐-피롤리딘-1-일)-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-{[(2-메탄술포닐-에틸)-메틸-카르바모일]-메틸}-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-옥소-2-(2-피리딘-4-일-피롤리딘-1-일)-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(2-히드록시-인단-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(6-페녹시-피리딘-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 [3-(3-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-시클로헥실메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3-플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-페녹시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-페닐-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-시아노-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-비페닐-4-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3-시아노-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(4-트리플루오로메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 [3-(3,5-디메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2,4-디메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(3-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 [3-(4-에틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 [3-(1-메틸-1H-이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(5-메톡시메틸-푸란-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(6-옥소-1,6-디히드로-피리딘-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1-에틸-3-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1-메틸-1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(2-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;티아졸-4-카르복실산 (3-푸란-3-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1,5-디메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3-페닐-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-플루오로-3-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(5-메틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-푸란-2-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;(6-{[(티아졸-4-카르보닐)-(3-트리플루오로메톡시-벤질)-아미노]-메틸}-3-아자-비시클로[3.1.0]헥스-3-일)-아세트산 부틸 에스테르티아졸-4-카르복실산 [3-(3-플루오로-4-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-에틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-에틸-5-메틸-3H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(테트라히드로-푸란-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-p-톨릴-에틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1-에틸-5-메틸-1H-피라졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-클로로-피리딘-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-이속사졸-3-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-인돌-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;2-메틸-3-(6-{[(티아졸-4-카르보닐)-(3-트리플루오로메톡시-벤질)-아미노]-메틸}-3-아자-비시클로[3.1.0]헥스-3-일)-프로피온산 에틸 에스테르티아졸-4-카르복실산 [3-(5-메틸-2H-피라졸-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-부톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-벤조[1,3]디옥솔-5-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-에톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-이소프로필-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-나프탈렌-2-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-벤조[1,3]디옥솔-4-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2,3-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2,5-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-퀴놀린-7-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-메톡시-3-메틸-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2,4-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 {3-[3-(5-메틸-푸란-2-일)-부틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1-피리미딘-2-일-1H-피롤-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3,5-디플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-디플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-퀴놀린-8-일메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-부틸-1H-이미다졸-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-인돌-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(3-시아노-4-플루오로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-인돌-5-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-플루오로-4-메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(1H-벤조이미다졸-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(2-클로로-티아졸-5-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 [3-(4-클로로-1-메틸-1H-피라졸-3-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-히드록시-인단-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(1-히드록시-시클로헥실메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(2-히드록시-인단-2-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로헥실메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로펜틸메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 시클로헥실메틸-(3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-히드록시-2-메틸-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로부틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-시클로헥실메틸-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(2-히드록시-시클로펜틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1,5-디메틸-1H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-메틸-이속사졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-프로필-이속사졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-이소프로폭시-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로펜틸옥시-4-플루오로-벤질)-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2-디메틸-프로폭시)-4-플루오로-벤질]-아미드;티아졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로헥실옥시-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3,5-디클로로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-이소프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;퀴놀린-2-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;피리딘-2-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-메틸-이속사졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-에틸-이속사졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;퀴놀린-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-시클로프로필-2H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1,5-디메틸-1H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;2-에틸-5-메틸-2H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;4-메틸-1H-이미다졸-2-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-프로필-이속사졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-이소프로필-2H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-에틸-2-메틸-2H-피라졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;2-이소프로필-티아졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;티아졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;5-클로로-피리딘-2-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 펜틸-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2-메틸-부틸)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2-에틸-부틸)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 시클로프로필메틸-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 헵틸-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 부틸-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 시클로헥실메틸-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(2-메틸-부틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸-프로필)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-펜틸-아미드;1-메틸-1H-이미다졸-4-카르복실산 부틸-[3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-시클로프로필메틸-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-클로로-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(2-에틸-부틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(테트라히드로-피란-4-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(4-히드록시-테트라히드로-피란-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(4-히드록시-테트라히드로-피란-4-일메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(테트라히드로-피란-4-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(테트라히드로-피란-4-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 시클로헥실메틸-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 시클로헥실메틸-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;6,7-디히드로-5H-피롤로[1,2-a]이미다졸-2-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-(4-트리플루오로메톡시-페닐)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-이소프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(3,3,3-트리플루오로-프로필)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-[2-(4-트리플루오로메톡시-페닐)-에틸]-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-(4-트리플루오로메틸-페닐)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-부틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-(4-트리플루오로메톡시-벤질)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-(4-트리플루오로메톡시-페닐)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-이소프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-프로필-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-부틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-(3-클로로-페닐)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-이소프로필-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-(4-트리플루오로메톡시-페닐)-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-피라진-2-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1H-벤조이미다졸-2-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-벤질)-아미드; 및N-(3-클로로-4-플루오로벤질)-N-((3-메틸-3-아자-비시클로[3.1.0]헥산-6-일)메틸)-1H-이미다졸-4-카르복스아미드로 이루어진 군으로부터 선택되는 것인 화합물 또는 그의 제약학적 염.
- 제7항에 있어서, 상기 화합물이1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-4-플루오로-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)- (4-플루오로-3-이소프로폭시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로펜틸옥시-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2-디메틸-프로폭시)-4-플루오로-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-시클로헥실옥시-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-1-트리플루오로메틸-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로펜틸메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-트리플루오로메톡시-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-시클로펜틸메틸-3-아자- 비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(4-트리플루오로메톡시-벤질)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-시클로프로필메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,5-디클로로-벤질)-(3-메틸-3-아자-비시 클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,5-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드 히드로클로라이드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2,4-디클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (2,4-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,4-디클로로-벤질)-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3,4-디클로로-벤질)-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메탄술포닐-아제티딘-3-일)-3-아자- 비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(4-플루오로-3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-클로로-4-플루오로-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (4-플루오로-3-트리플루오로메틸-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-4-플루오로-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-아제티딘-3-일-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메틸-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-클로로-벤질)-[3-(1-메틸-아제티딘-3-일)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 (3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-[3-(2,2,2-트리플루오로-1-트리플루오로메틸-에틸)-벤질]-아미드;1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로헥실메틸)-3-아자- 비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드;1-메틸-1H-이미다졸-4-카르복실산 {3-[2-(2-클로로-페닐)-2-히드록시-에틸]-3-아자-비시클로[3.1.0]헥스-6-일메틸}-(3-트리플루오로메톡시-벤질)-아미드; 및1-메틸-1H-이미다졸-4-카르복실산 [3-(1-히드록시-시클로펜틸메틸)-3-아자-비시클로[3.1.0]헥스-6-일메틸]-(3-트리플루오로메톡시-벤질)-아미드로 이루어진 군으로부터 선택되는 것인 화합물 또는 그의 제약학적 염.
- 삭제
- 삭제
- 4,5-디클로로-이소티아졸-3-카르복실산 (3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-(3-트리플루오로메톡시-벤질)-아미드, 또는 그의 제약학적으로 허용가능한 염 또는 용매화물.
- 2-클로로-N-(3-메틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-N-(1-메틸-1H-이미다졸-4-일메틸)-3-트리플루오로메틸-벤즈아미드, 또는 그의 제약학적으로 허용가능한 염 또는 용매화물.
- 3-클로로-N-(3-에틸-3-아자-비시클로[3.1.0]헥스-6-일메틸)-N-(1-메틸-1H-이미다졸-4-일메틸)-벤즈아미드, 또는 그의 제약학적으로 허용가능한 염 또는 용매화물.
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US60/669,472 | 2005-04-08 |
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KR1020077025888A KR100969402B1 (ko) | 2005-04-08 | 2006-03-27 | I형 글리신 수송 억제제로서의 비시클릭 [3.1.0]헤테로아릴 아미드 |
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Country | Link |
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US (2) | US20060229455A1 (ko) |
EP (1) | EP1869019B1 (ko) |
JP (1) | JP4193949B2 (ko) |
KR (1) | KR100969402B1 (ko) |
CN (1) | CN101189228A (ko) |
AP (1) | AP2007004198A0 (ko) |
AR (1) | AR056307A1 (ko) |
AU (1) | AU2006231917B2 (ko) |
BR (1) | BRPI0608148A2 (ko) |
CA (1) | CA2603939C (ko) |
CR (1) | CR9493A (ko) |
DK (1) | DK1869019T3 (ko) |
DO (1) | DOP2006000078A (ko) |
EA (1) | EA014311B1 (ko) |
ES (1) | ES2520015T3 (ko) |
GE (1) | GEP20105053B (ko) |
GT (1) | GT200600136A (ko) |
HN (1) | HN2006013804A (ko) |
IL (1) | IL186409A (ko) |
MA (1) | MA29672B1 (ko) |
MX (1) | MX2007012463A (ko) |
NL (1) | NL1031539C2 (ko) |
NO (1) | NO339422B1 (ko) |
NZ (1) | NZ563238A (ko) |
PE (1) | PE20061400A1 (ko) |
TN (1) | TNSN07380A1 (ko) |
TW (1) | TW200719890A (ko) |
UA (1) | UA88518C2 (ko) |
UY (1) | UY29456A1 (ko) |
WO (1) | WO2006106425A1 (ko) |
ZA (1) | ZA200708481B (ko) |
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WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
US8207205B2 (en) | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
US20090270398A1 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Pyridazine Derivatives |
WO2009131958A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising triazine derivatives |
FR2932479A1 (fr) | 2008-06-13 | 2009-12-18 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
CA2735764C (en) * | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
US20110237528A1 (en) * | 2008-09-19 | 2011-09-29 | Institute For Oneworld Health | Compositions and methods comprising imidazole and triazole derivatives |
US8642772B2 (en) * | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
EP2409976A4 (en) * | 2009-03-19 | 2012-09-19 | Taisho Pharmaceutical Co Ltd | GLYCINTRANSPORTERHEMMER |
US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US20100267706A1 (en) * | 2009-04-20 | 2010-10-21 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Pyridazine Derivatives |
US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
AR077472A1 (es) * | 2009-07-15 | 2011-08-31 | Taisho Pharmaceutical Co Ltd | Inhibidores de transportador de glicina |
AU2010316106B2 (en) | 2009-11-06 | 2015-10-22 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
MX350745B (es) | 2009-11-06 | 2017-09-14 | Sk Biopharmaceuticals Co Ltd * | El uso de un compuesto de carbamoilo para el tratamiento del sindrome de fibromialgia. |
US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
US20120035156A1 (en) * | 2010-08-09 | 2012-02-09 | Daniela Alberati | Combination of glyt1 compound with antipsychotics |
JP2013249257A (ja) * | 2010-09-16 | 2013-12-12 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害物質 |
EP2617715A4 (en) | 2010-09-17 | 2014-02-26 | Taisho Pharmaceutical Co Ltd | GLYCINE TRANSPORTER INHIBITOR |
JP2013249258A (ja) * | 2010-09-17 | 2013-12-12 | Taisho Pharmaceutical Co Ltd | グリシントランスポーター阻害物質 |
BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
US9394257B2 (en) * | 2012-10-16 | 2016-07-19 | Tolero Pharmaceuticals, Inc. | PKM2 modulators and methods for their use |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US9708334B2 (en) | 2014-04-24 | 2017-07-18 | Dart Neuroscience (Cayman) Ltd. | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors |
EP3215500A1 (en) | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Substituted azetidinyl compounds as glyt1 inhibitors |
MX2020005517A (es) | 2017-12-05 | 2020-11-09 | Sunovion Pharmaceuticals Inc | Formas cristalinas y metodos de produccion de las mismas. |
US10369134B2 (en) | 2017-12-05 | 2019-08-06 | Sunovion Pharmaceuticals Inc. | Nonracemic mixtures and uses thereof |
AU2020245437A1 (en) | 2019-03-22 | 2021-09-30 | Sumitomo Pharma Oncology, Inc. | Compositions comprising PKM2 modulators and methods of treatment using the same |
JP2022534425A (ja) | 2019-05-31 | 2022-07-29 | イケナ オンコロジー, インコーポレイテッド | Tead阻害剤およびその使用 |
TW202108571A (zh) | 2019-05-31 | 2021-03-01 | 美商醫肯納腫瘤學公司 | Tead抑制劑及其用途 |
KR20220018004A (ko) | 2019-06-04 | 2022-02-14 | 선오비온 파마슈티컬스 인코포레이티드 | 조절 방출 제형 및 이의 용도 |
US11813257B2 (en) | 2020-01-09 | 2023-11-14 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2003089411A1 (fr) | 2002-04-19 | 2003-10-30 | Sanofi-Aventis | Derives de n-[phenyl(piperidin-2-yl)methyl] benzamide, leur preparation et leur application en therapeutique |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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PL342818A1 (en) | 1998-03-06 | 2001-07-02 | Janssen Pharmaceutica Nv | Glycin transport inhibitors |
JP2002212179A (ja) | 2001-01-15 | 2002-07-31 | Wakunaga Pharmaceut Co Ltd | 新規アニリド誘導体又はその塩及びこれを含有する医薬 |
EP1442018A1 (en) | 2001-10-31 | 2004-08-04 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Novel anticancer compounds |
US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
UA86037C2 (ru) * | 2003-10-14 | 2009-03-25 | Пфайзер Продактс Инк. | Бициклические [3.1.0] производные, как ингибиторы переносчика глицина |
AU2005247943A1 (en) | 2004-05-23 | 2005-12-08 | Gerard M. Housey | Theramutein modulators |
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- 2006-03-27 WO PCT/IB2006/000947 patent/WO2006106425A1/en active Application Filing
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- 2006-04-06 PE PE2006000374A patent/PE20061400A1/es not_active Application Discontinuation
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- 2006-04-07 NL NL1031539A patent/NL1031539C2/nl not_active IP Right Cessation
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- 2007-10-07 IL IL186409A patent/IL186409A/en active IP Right Grant
- 2007-10-08 TN TNP2007000380A patent/TNSN07380A1/fr unknown
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2003089411A1 (fr) | 2002-04-19 | 2003-10-30 | Sanofi-Aventis | Derives de n-[phenyl(piperidin-2-yl)methyl] benzamide, leur preparation et leur application en therapeutique |
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