AR084754A1 - Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso - Google Patents
Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de usoInfo
- Publication number
- AR084754A1 AR084754A1 ARP110105031A ARP110105031A AR084754A1 AR 084754 A1 AR084754 A1 AR 084754A1 AR P110105031 A ARP110105031 A AR P110105031A AR P110105031 A ARP110105031 A AR P110105031A AR 084754 A1 AR084754 A1 AR 084754A1
- Authority
- AR
- Argentina
- Prior art keywords
- express
- stem cells
- composition
- placental stem
- composition according
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3616—Blood, e.g. platelet-rich plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
Abstract
Reivindicación 1: Una composición caracterizada porque comprende células madre placentarias y plasma rico en plaquetas, en donde la composición es adecuada para la inyección a un individuo, y en donde las células madre placentarias se adhieren al plástico para cultivo celular, son CD34-, CD10+, CD105+ y CD200+ y no son trofoblastos.Reivindicación 2: La composición de acuerdo con la reivindicación 1, caracterizada porque las células madre placentarias no se obtienen del cordón umbilical. Reivindicación 3: La composición de acuerdo con la reivindicación 1, caracterizada porque la composición no comprende un sustituto óseo implantable y no requiere trombina para retener las células madre placentarias en un sitio de inyección de dicha composición al individuo. Reivindicación 4: La composición de acuerdo con la reivindicación 1, caracterizada porque la inyección de dicha composición al individuo da como resultado la localización prolongada de las células madre placentarias en el sitio de inyección, con respecto a la inyección de células madre placentarias no combinadas con plasma rico en plaquetas. Reivindicación 5: La composición de acuerdo con la reivindicación 1, caracterizada porque las células madre placentarias expresan CD200 y no expresan HLA-G; o expresan CD73, CD105 y CD200; o expresan CD200 y OCT-4; o expresan CD73 y CD105 y no expresan HLA-G; o expresan CD73 y CD105 y facilitan la formación de uno o más cuerpos de tipo embrionario en una población de células placentarias que comprenden dicha célula madre cuando la población se cultiva en condiciones que permiten la formación de un cuerpo de tipo embrionario; o expresan OCT-4 y facilitan la formación de uno o más cuerpos de tipo embrionario en una población de células placentarias que comprenden dicha célula madre cuando la población se cultiva en condiciones que permiten la formación de cuerpos de tipo embrionario. Reivindicación 9: La composición de acuerdo con la reivindicación 1, caracterizada porque la relación volumen-volumen entre las células madre placentarias y el plasma rico en plaquetas en la composición es de alrededor de 1:1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061428721P | 2010-12-30 | 2010-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084754A1 true AR084754A1 (es) | 2013-06-05 |
Family
ID=45532031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110105031A AR084754A1 (es) | 2010-12-30 | 2011-12-29 | Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso |
Country Status (3)
Country | Link |
---|---|
US (1) | US20120171161A1 (es) |
AR (1) | AR084754A1 (es) |
WO (1) | WO2012092458A2 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100915482B1 (ko) | 2000-12-06 | 2009-09-03 | 하리리 로버트 제이 | 태반 줄기 세포의 회수 방법 |
MX348185B (es) | 2001-02-14 | 2017-06-02 | Anthrogenesis Corp | Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella. |
EP1976977B1 (en) | 2005-12-29 | 2015-07-08 | Anthrogenesis Corporation | Placental stem cell populations |
CN101878034B (zh) | 2007-09-28 | 2013-11-20 | 细胞基因细胞疗法公司 | 使用人胎盘灌洗液和人来自胎盘的中间体自然杀伤细胞的肿瘤抑制 |
AU2009283161A1 (en) | 2008-08-22 | 2010-02-25 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
AR077369A1 (es) | 2009-07-02 | 2011-08-24 | Anthrogenesis Corp | Metodopara producir eritrocitos sin celulas alimentadoras |
SI2556145T1 (sl) | 2010-04-07 | 2017-01-31 | Anthrogenesis Corporation | Angiogeneza z uporabo placentnih matičnih celic |
WO2011127113A1 (en) | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
CN113559126A (zh) | 2011-06-01 | 2021-10-29 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
CN108624654A (zh) | 2012-06-27 | 2018-10-09 | 新泽西鲁特格斯州立大学 | 通过使用流式细胞术的rna测量快速检测t细胞活化 |
CA2895106C (en) * | 2012-12-14 | 2023-01-24 | Anthrogenesis Corporation | Anoikis resistant placental stem cells and uses thereof |
NL2010225C2 (en) * | 2013-02-01 | 2014-08-04 | Conradus Ghosal Gho | Composition and method for preserving, transporting and storing living biological materials. |
EP3622960A1 (en) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Natural killer cells from placenta |
RU2718986C2 (ru) | 2013-03-15 | 2020-04-15 | Дженентек, Инк. | Композиции клеточных культур с антиоксидантами и способы получения полипептидов |
US20150273215A1 (en) * | 2014-03-26 | 2015-10-01 | Pacesetter, Inc. | Systems and methods for assessment of pain and other parameters during trial neurostimulation |
WO2016049485A1 (en) * | 2014-09-26 | 2016-03-31 | Anthrogenesis Corporation | Treatment of diabetic foot ulcer using placental stem cells |
KR20170102319A (ko) * | 2014-12-31 | 2017-09-08 | 안트로제네시스 코포레이션 | 혈소판을 분리하는 방법 |
US9173921B1 (en) * | 2015-03-23 | 2015-11-03 | Jaehyun Lim | Method of promoting hair growth by administration of bFGF |
TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
KR101738815B1 (ko) * | 2015-08-27 | 2017-05-23 | 심민보 | 혈소판 풍부 혈장을 포함하는 감각신경성 난청 또는 이명을 예방 또는 치료하기 위한 약학적 조성물 및 이를 이용한 방법 |
US10561684B2 (en) | 2015-08-27 | 2020-02-18 | Min Bo SHIM | Pharmaceutical composition for preventing or treating sensorineural hearing loss or tinnitus including platelet-rich plasma and method using the same |
TWI676478B (zh) * | 2016-05-20 | 2019-11-11 | 國璽幹細胞應用技術股份有限公司 | 一種用以製備治療糖尿病之醫藥組合物及其用途 |
KR102115960B1 (ko) * | 2018-11-28 | 2020-05-27 | 송미연 | 인간 중간엽 줄기세포를 갑상선 호르몬 분비세포로 분화 방법 |
CN111388649B (zh) * | 2020-03-19 | 2023-09-12 | 杭州三江上御生物科技有限公司 | 一种富血小板血浆胎盘多肽组合物及其应用 |
CN112402365B (zh) * | 2020-10-26 | 2023-10-03 | 山东博森医学工程技术有限公司 | 一种用于治疗椎间盘退变疾病的prp凝胶负载脐带间充质干细胞组合物 |
CN115998668A (zh) * | 2021-05-24 | 2023-04-25 | 禾美生物科技(浙江)有限公司 | 脐带间充质干细胞活性肽分泌物、制备方法、应用及皮肤微生态调节剂 |
CN113398246B (zh) * | 2021-06-30 | 2022-09-20 | 上海市皮肤病医院 | eIF3I-PDL1-IRS4轴在制备难治性溃疡药物中的应用 |
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US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
EP2316919B1 (en) | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
MX348185B (es) | 2001-02-14 | 2017-06-02 | Anthrogenesis Corp | Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella. |
US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
NZ597304A (en) | 2005-10-13 | 2013-06-28 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
EP1976977B1 (en) * | 2005-12-29 | 2015-07-08 | Anthrogenesis Corporation | Placental stem cell populations |
CN101374941A (zh) | 2005-12-29 | 2009-02-25 | 人类起源公司 | 采集和保存胎盘干细胞的改良组合物及其使用方法 |
CN101501185A (zh) * | 2006-06-09 | 2009-08-05 | 人类起源公司 | 胎盘巢(placental niche)及其培养干细胞的用途 |
CN101657206B (zh) | 2007-02-12 | 2013-07-03 | 人类起源公司 | 利用胎盘干细胞治疗炎性疾病 |
WO2010141654A1 (en) * | 2009-06-05 | 2010-12-09 | Anthrogenesis Corporation | Improved method of collecting placental cells |
CN102822330A (zh) * | 2010-01-26 | 2012-12-12 | 人类起源公司 | 使用胎盘干细胞对骨相关癌的治疗 |
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2011
- 2011-12-29 WO PCT/US2011/067785 patent/WO2012092458A2/en active Application Filing
- 2011-12-29 AR ARP110105031A patent/AR084754A1/es unknown
- 2011-12-29 US US13/340,557 patent/US20120171161A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20120171161A1 (en) | 2012-07-05 |
WO2012092458A2 (en) | 2012-07-05 |
WO2012092458A3 (en) | 2012-08-23 |
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