KR100510253B1 - 항산화, 항관절염 및 항치매 효과를 지니는 기능성 식품조성물 - Google Patents
항산화, 항관절염 및 항치매 효과를 지니는 기능성 식품조성물 Download PDFInfo
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- KR100510253B1 KR100510253B1 KR10-2003-0028349A KR20030028349A KR100510253B1 KR 100510253 B1 KR100510253 B1 KR 100510253B1 KR 20030028349 A KR20030028349 A KR 20030028349A KR 100510253 B1 KR100510253 B1 KR 100510253B1
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- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229930002161 purine alkaloid Natural products 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- SVHDRHWULLNMQC-UHFFFAOYSA-N scoparone Natural products C1=CC(=O)OC2=C1C=C(C(=O)C)C(C(C)=O)=C2 SVHDRHWULLNMQC-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 235000015192 vegetable juice Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
DPPH 라디칼 소거활성 (%) | |
녹차 | 95.03 |
인진쑥 | 85.43 |
솔잎 | 66.05 |
미나리 | 34.19 |
가시오가피 | 38.35 |
모과 | 43.60 |
어성초 | 24.87 |
생강 | 44.22 |
양파 | 41.23 |
비타민 C | 95.93 |
DPPH 라디칼 소거활성 (IC50 ppm (μM)) | |||
녹차 | 인진쑥 | 솔잎 | 비타민 C |
5.46 | 22.50 | 35.96 | 3.86 (21.93) |
DPPH 라디칼 소거활성 (IC50 ppm (μM) | ||||||
실시예 3의 기능성조성물 | 비타민 C | 피크노제놀 | 비타민 E | (±)-카테친 | β-카로틴 | 아스타산틴 |
6.89 | 3.86 (21.93) | 6.38 | 9.97 (23.14) | 3.24 (11.17) | 〉50(〉93.12) | 8.83 (14.79) |
본 검 | 맹 검(Blank) | |||
반응군 | 대조군 | 반응군 | 대조군 | |
시료 | 0.05 ㎖ (시료) | 0.05 ㎖(시료를 용해한 용매) | 0.05 ㎖(시료) | 0.05 ㎖(시료를 용해한 용매) |
발색액 | 0.5 ㎖ | 0.5 ㎖ | 0.5 ㎖ | 0.5 ㎖ |
효소액 | 0.5 ㎖ | 0.5 ㎖ | - | - |
완충용액 | - | - | 0.5 ㎖ | 0.5 ㎖ |
37 ℃에서 20분간 가온 | ||||
반응정지액 | 1.0 ㎖ | 1.0 ㎖ | 1.0 ㎖ | 1.0 ㎖ |
잘 흔들어 섞은 후, 물을 대조군으로 560nm에서 흡광도 측정 | ||||
흡광도 | Asample | Acontrol | Bsample | Bcontrol |
슈퍼옥사이드 음이온(1O2 -) 소거 활성 (IC50 ppm (μM) | ||||||
실시예 3의 기능성조성믈 | 비타민 C | 피크노제놀 | 비타민 E | (±)-카테친 | β-카로틴 | 아스타산틴 |
1.17 | 6.36 (36.13) | 2.26 | 〉24.39(〉56.60) | 3.22 (11.09) | 〉24.39(〉45.43) | 20.48 (34.31) |
농도 (ppm) | 하이드록시라디칼(·OH) 소거활성 (%) | |||
시료농도 | 전체반응시료농도 | 실시예 3의 기능성조성물 | 비타민 C | 피크노제놀 |
10,000 | 2,000 | 82.97 | 96.39 | 57.64 |
1,000 | 200 | 15.56 | 85.14 | -6.61 |
COX 저해활성 (IC50 ppm (μM)) | IC50의 비COX-2/COX-1 | ||
COX-1 | COX-2 | ||
실시예 3의기능성 조성물 | 2.24 | 11.67 | 5.209 |
*셀레코십 | 4.07 (10.7) | 0.01 (0.036) | 0.002 (0.00336) |
*로페코십 | 〉157.18 (〉500) | 0.10 (0.321) | 0.0006 (0.0006) |
*인도메타신 | 0.02 (0.067) | 2.79 (7.8) | 139.5 (116.4) |
* :Eur. J. Med. Chem 3. 339-347. (2002) 내의 내용 |
PEP 저해 활성 (IC50 ppm (μM)) | ||
실시예 3의 기능성조성물 | *스타우로스포린 | **프로페틴 |
4.55 | 0.359 (0.77 μM) | 2.55 (1.1 μM) |
* Agri.. Biol. Chem. 54(11), 3021-3022, 1990 내의 내용 ** The Journal of Antibiotics 50, 373-378, 1997 내의 내용 |
Claims (8)
- 녹차 수용성 추출물 40~70 중량 %, 인진쑥 수용성 추출물 14~40 중량 %, 솔잎 수용성 추출물 14~40 중량 % 및 비타민 C 2~10 중량 %로 구성되는 항치매 효과를 지니는 기능성 식품 조성물.
- 삭제
- 삭제
- 삭제
- 삭제
- 제 1항에 있어서, 상기 조성물은 건강 음료 또는 음료 첨가제로 사용됨을 특징으로 하는 식품 조성물.
- 제 1항에 있어서, 상기 조성물은 캡슐제 형태인 식품 조성물.
- 녹차 수용성 추출물 40~70 중량 %, 인진쑥 수용성 추출물 14~40 중량 %, 솔잎 수용성 추출물 14~40 중량 % 및 비타민 C 2~10 중량 %로 구성되는 항치매 효과를 갖는 식품첨가제.
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Cited By (3)
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KR101376198B1 (ko) | 2012-03-22 | 2014-03-19 | 경남대학교 산학협력단 | 다시마를 포함하는 항산화 또는 항당뇨용 건강기능식품용 조성물 및 기능성 음료 조성물 |
KR20210067236A (ko) | 2019-11-29 | 2021-06-08 | 주식회사 에이치엠 | 약용식물 추출물을 포함하는 식품 첨가 조성물의 제조방법 및 이에 의해 제조된 식품 첨가 조성물 |
KR20220055802A (ko) | 2020-10-27 | 2022-05-04 | 서울대학교산학협력단 | 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매 예방 또는 개선용 조성물 및 이의 용도 |
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KR101302163B1 (ko) | 2011-10-12 | 2013-08-30 | 경희대학교 산학협력단 | 어성초 추출물을 유효성분으로 함유하는 치매, 파킨슨병 또는 간질 예방 및 치료용 약학적 조성물 |
KR101373245B1 (ko) * | 2012-02-02 | 2014-03-11 | 충북대학교 산학협력단 | 천연 생약추출물을 유효성분으로 포함하는 골 관절염 예방 또는 치료용 조성물 |
KR102463087B1 (ko) * | 2021-02-05 | 2022-11-03 | 단국대학교 천안캠퍼스 산학협력단 | 항치매 및 항산화 활성을 가지는 인진쑥 발효물 및 이의 제조방법 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101376198B1 (ko) | 2012-03-22 | 2014-03-19 | 경남대학교 산학협력단 | 다시마를 포함하는 항산화 또는 항당뇨용 건강기능식품용 조성물 및 기능성 음료 조성물 |
KR20210067236A (ko) | 2019-11-29 | 2021-06-08 | 주식회사 에이치엠 | 약용식물 추출물을 포함하는 식품 첨가 조성물의 제조방법 및 이에 의해 제조된 식품 첨가 조성물 |
KR20220055802A (ko) | 2020-10-27 | 2022-05-04 | 서울대학교산학협력단 | 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매 예방 또는 개선용 조성물 및 이의 용도 |
KR20220162675A (ko) | 2020-10-27 | 2022-12-08 | 서울대학교산학협력단 | 단백질 발현 억제제를 포함하는 항산화, 항염 및 치매 예방 또는 개선용 조성물 및 이의 용도 |
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