JPWO2021180205A5 - - Google Patents
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- JPWO2021180205A5 JPWO2021180205A5 JP2022551318A JP2022551318A JPWO2021180205A5 JP WO2021180205 A5 JPWO2021180205 A5 JP WO2021180205A5 JP 2022551318 A JP2022551318 A JP 2022551318A JP 2022551318 A JP2022551318 A JP 2022551318A JP WO2021180205 A5 JPWO2021180205 A5 JP WO2021180205A5
- Authority
- JP
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- Prior art keywords
- seq
- pvrig
- nos
- cancer
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims description 102
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims description 102
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 68
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 68
- 239000000427 antigen Substances 0.000 claims description 56
- 102000036639 antigens Human genes 0.000 claims description 56
- 108091007433 antigens Proteins 0.000 claims description 56
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 37
- 108060003951 Immunoglobulin Proteins 0.000 claims description 34
- 102000018358 immunoglobulin Human genes 0.000 claims description 34
- 102000023732 binding proteins Human genes 0.000 claims description 32
- 108091008324 binding proteins Proteins 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 29
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 7
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- 101001037139 Homo sapiens Immunoglobulin heavy variable 3-30 Proteins 0.000 claims description 2
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- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010174835 | 2020-03-13 | ||
CN202010174835.4 | 2020-03-13 | ||
PCT/CN2021/080470 WO2021180205A1 (fr) | 2020-03-13 | 2021-03-12 | Protéine de liaison à pvgrig et ses utilisations médicales |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023516936A JP2023516936A (ja) | 2023-04-21 |
JPWO2021180205A5 true JPWO2021180205A5 (fr) | 2024-04-26 |
Family
ID=77672140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022551318A Pending JP2023516936A (ja) | 2020-03-13 | 2021-03-12 | Pvrig結合タンパク質及びその医薬用途 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20240043530A1 (fr) |
EP (1) | EP4119162A4 (fr) |
JP (1) | JP2023516936A (fr) |
KR (1) | KR20220154140A (fr) |
CN (1) | CN115003333A (fr) |
CA (1) | CA3170025A1 (fr) |
TW (1) | TW202144417A (fr) |
WO (1) | WO2021180205A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117858903A (zh) * | 2021-09-15 | 2024-04-09 | 江苏恒瑞医药股份有限公司 | 一种含抗pvrig/tigit双特异性抗体的药物组合物 |
TW202327649A (zh) * | 2021-09-15 | 2023-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Pvrig/tigit結合蛋白聯合免疫檢查點抑制劑用於治療癌症 |
CN116925233A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗tigit-抗pvrig双特异性抗体、其药物组合物及用途 |
CN116925222A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗pvrig抗体、其药物组合物及用途 |
WO2023236980A1 (fr) * | 2022-06-08 | 2023-12-14 | 山东先声生物制药有限公司 | Composition pharmaceutique d'anticorps bispécifique pvrig/tigit et son utilisation |
WO2024027824A1 (fr) * | 2022-08-05 | 2024-02-08 | 上海君实生物医药科技股份有限公司 | Composition pharmaceutique d'anticorps anti-cd112r et son utilisation |
WO2024032700A1 (fr) * | 2022-08-10 | 2024-02-15 | Beigene, Ltd. | Anticorps anti-pvrig et procédés d'utilisation |
CN117957254A (zh) * | 2022-08-31 | 2024-04-30 | 石药集团巨石生物制药有限公司 | 抗pvrig抗体及其应用 |
WO2024098980A1 (fr) * | 2022-11-10 | 2024-05-16 | Huahui Health Ltd. | Anticorps anti-cd112r et leur utilisation |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
EP0672142B1 (fr) | 1992-12-04 | 2001-02-28 | Medical Research Council | Proteines de liaison multivalentes et multispecifiques, leur fabrication et leur utilisation |
AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
AU2002357060A1 (en) | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
KR101855381B1 (ko) | 2008-04-09 | 2018-05-09 | 제넨테크, 인크. | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
JP2016500251A (ja) | 2012-12-03 | 2016-01-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 免疫調節Fc融合タンパク質の抗癌活性の増強 |
TWI685349B (zh) | 2013-07-16 | 2020-02-21 | 建南德克公司 | 利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法 |
US20170107300A1 (en) | 2014-03-21 | 2017-04-20 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring |
US11505605B2 (en) | 2014-05-13 | 2022-11-22 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
AU2015305754B2 (en) | 2014-08-19 | 2018-10-25 | Merck Sharp & Dohme Llc | Anti-tigit antibodies |
SG10202006538TA (en) | 2014-12-23 | 2020-08-28 | Bristol Myers Squibb Co | Antibodies to tigit |
PT3258951T (pt) * | 2015-02-19 | 2020-08-18 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
US10550173B2 (en) * | 2015-02-19 | 2020-02-04 | Compugen, Ltd. | PVRIG polypeptides and methods of treatment |
WO2017030823A2 (fr) | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anticorps anti-tigit |
BR112018005862A2 (pt) | 2015-09-25 | 2018-10-16 | Genentech, Inc. | anticorpos, anticorpos isolados, polinucleotídeo, vetor, célula hospedeira, método de produção do anticorpo, imunoconjugado, composição, usos dos anticorpos, métodos para tratar ou retardar a progressão de um câncer e de uma doença e para aumentar, potencializar ou estimular uma resposta ou função imune e kit |
WO2017066714A1 (fr) * | 2015-10-16 | 2017-04-20 | Compugen Ltd. | Conjugués d'anticorps anti-vsig1 et de médicaments |
LT3347379T (lt) * | 2016-08-17 | 2020-05-11 | Compugen Ltd. | Anti-tigit antikūnai, anti-pvrig antikūnai ir jų kombinacijos |
KR20200021474A (ko) * | 2017-06-01 | 2020-02-28 | 컴퓨젠 엘티디. | 삼중 조합 항체 치료제 |
WO2019062832A1 (fr) | 2017-09-29 | 2019-04-04 | 江苏恒瑞医药股份有限公司 | Anticorps tigit, fragment de liaison à l'antigène de celui-ci, et son utilisation médicale |
EP3802605A1 (fr) * | 2018-06-01 | 2021-04-14 | Compugen Ltd. | Anticorps bispécifiques anti-pvrig/anti-tigit et procédés d'utilisation |
-
2021
- 2021-03-12 CN CN202180010585.3A patent/CN115003333A/zh active Pending
- 2021-03-12 US US17/905,694 patent/US20240043530A1/en active Pending
- 2021-03-12 CA CA3170025A patent/CA3170025A1/fr active Pending
- 2021-03-12 TW TW110108958A patent/TW202144417A/zh unknown
- 2021-03-12 EP EP21768888.6A patent/EP4119162A4/fr active Pending
- 2021-03-12 JP JP2022551318A patent/JP2023516936A/ja active Pending
- 2021-03-12 KR KR1020227034534A patent/KR20220154140A/ko active Search and Examination
- 2021-03-12 WO PCT/CN2021/080470 patent/WO2021180205A1/fr active Application Filing
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