JPWO2021180205A5 - - Google Patents
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- JPWO2021180205A5 JPWO2021180205A5 JP2022551318A JP2022551318A JPWO2021180205A5 JP WO2021180205 A5 JPWO2021180205 A5 JP WO2021180205A5 JP 2022551318 A JP2022551318 A JP 2022551318A JP 2022551318 A JP2022551318 A JP 2022551318A JP WO2021180205 A5 JPWO2021180205 A5 JP WO2021180205A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pvrig
- nos
- cancer
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 101001102797 Homo sapiens Transmembrane protein PVRIG Proteins 0.000 claims description 102
- 102100039630 Transmembrane protein PVRIG Human genes 0.000 claims description 102
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 68
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 68
- 239000000427 antigen Substances 0.000 claims description 56
- 102000036639 antigens Human genes 0.000 claims description 56
- 108091007433 antigens Proteins 0.000 claims description 56
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 37
- 108060003951 Immunoglobulin Proteins 0.000 claims description 34
- 102000018358 immunoglobulin Human genes 0.000 claims description 34
- 102000023732 binding proteins Human genes 0.000 claims description 32
- 108091008324 binding proteins Proteins 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 19
- 239000012634 fragment Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 230000002062 proliferating effect Effects 0.000 claims description 11
- 206010009944 Colon cancer Diseases 0.000 claims description 9
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- 206010017758 gastric cancer Diseases 0.000 claims description 8
- 201000011549 stomach cancer Diseases 0.000 claims description 8
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
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- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 5
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- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 5
- 201000010881 cervical cancer Diseases 0.000 claims description 5
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- 102000004127 Cytokines Human genes 0.000 claims description 3
- 108090000695 Cytokines Proteins 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
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- 101001037139 Homo sapiens Immunoglobulin heavy variable 3-30 Proteins 0.000 claims description 2
- 101001037153 Homo sapiens Immunoglobulin heavy variable 3-7 Proteins 0.000 claims description 2
- 102100040219 Immunoglobulin heavy variable 3-30 Human genes 0.000 claims description 2
- 102100040231 Immunoglobulin heavy variable 3-7 Human genes 0.000 claims description 2
- 210000004602 germ cell Anatomy 0.000 claims description 2
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- 238000004519 manufacturing process Methods 0.000 claims 1
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- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 4
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- 241001465754 Metazoa Species 0.000 description 3
- 206010041067 Small cell lung cancer Diseases 0.000 description 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
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- 239000002953 phosphate buffered saline Substances 0.000 description 3
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- 208000000587 small cell lung carcinoma Diseases 0.000 description 3
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- 238000003127 radioimmunoassay Methods 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 206010004053 Bacterial toxaemia Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000032320 Germ cell tumor of testis Diseases 0.000 description 1
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- 206010018338 Glioma Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000001265 Jonckheere trend test Methods 0.000 description 1
- 238000012313 Kruskal-Wallis test Methods 0.000 description 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 description 1
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- 241000700159 Rattus Species 0.000 description 1
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
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- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 1
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- 210000003608 fece Anatomy 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010174835 | 2020-03-13 | ||
| CN202010174835.4 | 2020-03-13 | ||
| PCT/CN2021/080470 WO2021180205A1 (fr) | 2020-03-13 | 2021-03-12 | Protéine de liaison à pvgrig et ses utilisations médicales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023516936A JP2023516936A (ja) | 2023-04-21 |
| JPWO2021180205A5 true JPWO2021180205A5 (fr) | 2024-04-26 |
Family
ID=77672140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022551318A Pending JP2023516936A (ja) | 2020-03-13 | 2021-03-12 | Ｐｖｒｉｇ結合タンパク質及びその医薬用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240043530A1 (fr) |
| EP (1) | EP4119162A4 (fr) |
| JP (1) | JP2023516936A (fr) |
| KR (1) | KR20220154140A (fr) |
| CN (1) | CN115003333A (fr) |
| CA (1) | CA3170025A1 (fr) |
| TW (1) | TW202144417A (fr) |
| WO (1) | WO2021180205A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117858903A (zh) * | 2021-09-15 | 2024-04-09 | 江苏恒瑞医药股份有限公司 | 一种含抗pvrig/tigit双特异性抗体的药物组合物 |
| TW202327649A (zh) * | 2021-09-15 | 2023-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｐｖｒｉｇ／ｔｉｇｉｔ結合蛋白聯合免疫檢查點抑制劑用於治療癌症 |
| CN116925233A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗tigit-抗pvrig双特异性抗体、其药物组合物及用途 |
| CN116925222A (zh) * | 2022-04-02 | 2023-10-24 | 普米斯生物技术(珠海)有限公司 | 抗pvrig抗体、其药物组合物及用途 |
| WO2023236980A1 (fr) * | 2022-06-08 | 2023-12-14 | 山东先声生物制药有限公司 | Composition pharmaceutique d'anticorps bispécifique pvrig/tigit et son utilisation |
| WO2024027824A1 (fr) * | 2022-08-05 | 2024-02-08 | 上海君实生物医药科技股份有限公司 | Composition pharmaceutique d'anticorps anti-cd112r et son utilisation |
| WO2024032700A1 (fr) * | 2022-08-10 | 2024-02-15 | Beigene, Ltd. | Anticorps anti-pvrig et procédés d'utilisation |
| CN117957254A (zh) * | 2022-08-31 | 2024-04-30 | 石药集团巨石生物制药有限公司 | 抗pvrig抗体及其应用 |
| WO2024098980A1 (fr) * | 2022-11-10 | 2024-05-16 | Huahui Health Ltd. | Anticorps anti-cd112r et leur utilisation |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
| EP0672142B1 (fr) | 1992-12-04 | 2001-02-28 | Medical Research Council | Proteines de liaison multivalentes et multispecifiques, leur fabrication et leur utilisation |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| AU2002357060A1 (en) | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| KR101855381B1 (ko) | 2008-04-09 | 2018-05-09 | 제넨테크, 인크. | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
| JP2016500251A (ja) | 2012-12-03 | 2016-01-12 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 免疫調節Ｆｃ融合タンパク質の抗癌活性の増強 |
| TWI685349B (zh) | 2013-07-16 | 2020-02-21 | 建南德克公司 | 利用ｐｄ-１軸結合拮抗劑及ｔｉｇｉｔ抑制劑治療癌症之方法 |
| US20170107300A1 (en) | 2014-03-21 | 2017-04-20 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring |
| US11505605B2 (en) | 2014-05-13 | 2022-11-22 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| AU2015305754B2 (en) | 2014-08-19 | 2018-10-25 | Merck Sharp & Dohme Llc | Anti-tigit antibodies |
| SG10202006538TA (en) | 2014-12-23 | 2020-08-28 | Bristol Myers Squibb Co | Antibodies to tigit |
| PT3258951T (pt) * | 2015-02-19 | 2020-08-18 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
| US10550173B2 (en) * | 2015-02-19 | 2020-02-04 | Compugen, Ltd. | PVRIG polypeptides and methods of treatment |
| WO2017030823A2 (fr) | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anticorps anti-tigit |
| BR112018005862A2 (pt) | 2015-09-25 | 2018-10-16 | Genentech, Inc. | anticorpos, anticorpos isolados, polinucleotídeo, vetor, célula hospedeira, método de produção do anticorpo, imunoconjugado, composição, usos dos anticorpos, métodos para tratar ou retardar a progressão de um câncer e de uma doença e para aumentar, potencializar ou estimular uma resposta ou função imune e kit |
| WO2017066714A1 (fr) * | 2015-10-16 | 2017-04-20 | Compugen Ltd. | Conjugués d'anticorps anti-vsig1 et de médicaments |
| LT3347379T (lt) * | 2016-08-17 | 2020-05-11 | Compugen Ltd. | Anti-tigit antikūnai, anti-pvrig antikūnai ir jų kombinacijos |
| KR20200021474A (ko) * | 2017-06-01 | 2020-02-28 | 컴퓨젠 엘티디. | 삼중 조합 항체 치료제 |
| WO2019062832A1 (fr) | 2017-09-29 | 2019-04-04 | 江苏恒瑞医药股份有限公司 | Anticorps tigit, fragment de liaison à l'antigène de celui-ci, et son utilisation médicale |
| EP3802605A1 (fr) * | 2018-06-01 | 2021-04-14 | Compugen Ltd. | Anticorps bispécifiques anti-pvrig/anti-tigit et procédés d'utilisation |
-
2021
- 2021-03-12 CN CN202180010585.3A patent/CN115003333A/zh active Pending
- 2021-03-12 US US17/905,694 patent/US20240043530A1/en active Pending
- 2021-03-12 CA CA3170025A patent/CA3170025A1/fr active Pending
- 2021-03-12 TW TW110108958A patent/TW202144417A/zh unknown
- 2021-03-12 EP EP21768888.6A patent/EP4119162A4/fr active Pending
- 2021-03-12 JP JP2022551318A patent/JP2023516936A/ja active Pending
- 2021-03-12 KR KR1020227034534A patent/KR20220154140A/ko active Search and Examination
- 2021-03-12 WO PCT/CN2021/080470 patent/WO2021180205A1/fr active Application Filing
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