US5658920A
(en)
|
1991-01-16 |
1997-08-19 |
Daiichi Pharmaceutical Co., Ltd. |
Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
|
US6504029B1
(en)
|
1995-04-10 |
2003-01-07 |
Daiichi Pharmaceutical Co., Ltd. |
Condensed-hexacyclic compounds and a process therefor
|
ES2183004T3
(es)
|
1995-08-02 |
2003-03-16 |
Univ Newcastle Ventures Ltd |
Compuestos de benzimidazol.
|
KR20000064811A
(ko)
|
1996-04-26 |
2000-11-06 |
스즈키 다다시 |
테트라히드로인돌리진 유도체의 제조법
|
TW409058B
(en)
|
1996-06-06 |
2000-10-21 |
Daiichi Seiyaku Co |
Method for preparation of a drug complex
|
TW527183B
(en)
|
1996-06-06 |
2003-04-11 |
Daiichi Seiyaku Co |
Drug complex
|
IN189180B
(zh)
|
1997-07-09 |
2003-01-04 |
Chong Kun Dang Corp |
|
TWI253935B
(en)
|
1998-05-22 |
2006-05-01 |
Daiichi Seiyaku Co |
Drug complex
|
WO2000025825A1
(fr)
|
1998-10-30 |
2000-05-11 |
Daiichi Pharmaceutical Co., Ltd. |
Composes dds et procede de dosage de ces composes
|
DE59911249D1
(de)
|
1998-11-03 |
2005-01-13 |
Abbott Gmbh & Co Kg |
Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung
|
EP1140936B1
(en)
|
1999-01-11 |
2004-03-17 |
Agouron Pharmaceuticals, Inc. |
Tricyclic inhibitors of poly(adp-ribose) polymerases
|
DE19920936A1
(de)
|
1999-05-07 |
2000-11-09 |
Basf Ag |
Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
|
ECSP003637A
(es)
|
1999-08-31 |
2002-03-25 |
Agouron Pharma |
Inhibidores triciclicos de poli (adp-ribosa) polimerasas
|
US6699876B2
(en)
|
1999-11-18 |
2004-03-02 |
Les Laboratoires Servier |
Camptothecin analogue compounds
|
WO2001041534A2
(en)
|
1999-12-13 |
2001-06-14 |
Eli Lilly And Company |
Pseudomycin phosphate prodrugs
|
CN1556712A
(zh)
|
2000-07-13 |
2004-12-22 |
��һ��������ҩ��ʽ���� |
含dds化合物的药用组合物
|
US7151102B2
(en)
|
2000-10-30 |
2006-12-19 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
JP4477881B2
(ja)
|
2002-03-01 |
2010-06-09 |
ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド |
治療剤または細胞毒性剤と生物活性ペプチドとの抱合体
|
BR0308737A
(pt)
|
2002-03-20 |
2005-01-11 |
Bristol Myers Squibb Co |
Pró-drogas de fosfato de fluoroxindóis
|
ES2357057T3
(es)
|
2002-04-30 |
2011-04-15 |
Kudos Pharmaceuticals Limited |
Derivados de ftalazinona.
|
US7449464B2
(en)
|
2003-03-12 |
2008-11-11 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
JP2006522088A
(ja)
|
2003-03-31 |
2006-09-28 |
ファイザー・インク |
ポリ(adp−リボース)ポリメラーゼの三環系阻害剤の塩
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
MX369959B
(es)
|
2003-05-14 |
2019-11-27 |
Immunogen Inc |
Composicion de farmaco conjugado.
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
WO2004103272A2
(en)
|
2003-05-20 |
2004-12-02 |
Immunogen, Inc. |
Improved cytotoxic agents comprising new maytansinoids
|
KR101138471B1
(ko)
|
2003-07-25 |
2012-04-25 |
화이자 인코포레이티드 |
트리시클로 parp 저해제
|
GB0317466D0
(en)
|
2003-07-25 |
2003-08-27 |
Univ Sheffield |
Use
|
DK1684736T3
(da)
|
2003-12-01 |
2011-11-21 |
Kudos Pharm Ltd |
Inhibitorer af DNA-skadereparation til behandling af cancer
|
WO2005082023A2
(en)
|
2004-02-23 |
2005-09-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
CN101098854B
(zh)
*
|
2004-07-23 |
2012-12-05 |
恩多塞特公司 |
二价连接体及其轭合物
|
MX2007003314A
(es)
|
2004-09-22 |
2007-08-06 |
Pfizer |
Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas.
|
ES2337275T3
(es)
|
2004-09-22 |
2010-04-22 |
Pfizer, Inc. |
Procedimiento de preparacion de inhidores de poli(adp-ribosa)-polimrerasas.
|
EP1799685B1
(en)
|
2004-09-22 |
2012-03-28 |
Pfizer Inc. |
Polymorphic forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
|
PL1819359T3
(pl)
|
2004-12-09 |
2015-08-31 |
Janssen Biotech Inc |
Immunokoniugaty skierowane przeciw integrynie, metody ich wytwarzania oraz ich zastosowanie
|
WO2006078816A2
(en)
|
2005-01-18 |
2006-07-27 |
The Board Of Governors For Higher Education |
Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally senstive transmembrane peptide
|
US7301019B2
(en)
|
2005-01-21 |
2007-11-27 |
Immunogen, Inc. |
Method for the preparation of maytansinoid esters
|
WO2006086733A2
(en)
|
2005-02-11 |
2006-08-17 |
Immunogen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
JP2008538365A
(ja)
|
2005-04-15 |
2008-10-23 |
イミュノジェン・インコーポレーテッド |
腫瘍内の不均一または混合細胞集団を排除する方法
|
CA3000520C
(en)
|
2005-08-24 |
2023-04-04 |
Immunogen, Inc. |
Process for preparing antibody maytansinoid conjugates
|
ES2378692T3
(es)
|
2005-09-29 |
2012-04-17 |
Abbott Laboratories |
Las 1H-benzimidazol-4-carboxamidas sustituidas con fenilo en la posición 2 son potentes inhibidores de PARP
|
EP1945647B9
(en)
|
2005-11-08 |
2012-11-14 |
Immunogen, Inc. |
Processes for preparation of maytansinol
|
SI2338487T1
(sl)
|
2006-01-17 |
2014-01-31 |
Abbott Laboratories |
Kombinacijska terapija z inhibitorji PARP
|
UY30639A1
(es)
|
2006-10-17 |
2008-05-31 |
Kudos Pharm Ltd |
Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
|
WO2008084261A1
(en)
|
2007-01-10 |
2008-07-17 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
WO2008114114A2
(en)
|
2007-03-16 |
2008-09-25 |
Pfizer Products Inc. |
Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition
|
JP5690589B2
(ja)
*
|
2007-06-25 |
2015-03-25 |
エンドサイト・インコーポレイテッドEndocyte, Inc. |
親水性スペーサーリンカーを含有する結合体
|
US8067613B2
(en)
|
2007-07-16 |
2011-11-29 |
Abbott Laboratories |
Benzimidazole poly(ADP ribose)polymerase inhibitors
|
PL2187965T3
(pl)
|
2007-08-17 |
2020-05-18 |
Purdue Research Foundation |
Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania
|
BRPI0911442A2
(pt)
|
2008-04-30 |
2019-03-12 |
Immunogen, Inc. |
conjugados potentes e ligantes hidrofílicos
|
KR102560218B1
(ko)
|
2009-06-03 |
2023-07-26 |
이뮤노젠 아이엔씨 |
접합 방법
|
WO2011066418A1
(en)
|
2009-11-25 |
2011-06-03 |
Academia Sinica |
The tumor-selective anti-cancer prodrug bqc-g
|
PT3150610T
(pt)
|
2010-02-12 |
2019-11-11 |
Pfizer |
Sais e polrmorfos de 8-fluor0-2-{4- [(metilamino}metil]fenil}-1,3,4,5-tetrahidr0-6hazepin0[ 5,4,3-cd]indol-6-0na
|
WO2011106639A1
(en)
*
|
2010-02-25 |
2011-09-01 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
SI3290428T1
(sl)
|
2010-03-31 |
2022-01-31 |
Gilead Pharmasset Llc |
Tableta, ki obsega kristalinični (S)-izopropil 2-(((S)-(((2R,3R,4R,5R) -5-(2,4-diokso-3,4-dihidropirimidin-1(2H)-il)-4-fluoro-3-hidroksi-4- metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat
|
WO2011140393A1
(en)
|
2010-05-05 |
2011-11-10 |
Prolynx Llc |
Controlled release from macromolecular conjugates
|
CA3032185C
(en)
|
2010-07-13 |
2021-08-03 |
Council on Postsecondary Education, State of Rhode Island and Providence Plantations |
Environmentally sensitive composition comprising a ph triggered peptide and uses thereof
|
EP2603201B1
(en)
|
2010-08-13 |
2020-03-11 |
Rhode Island Board of Governors for Higher Education |
Liposome compositions and methods of use thereof
|
BR112013010853A2
(pt)
|
2010-11-03 |
2016-08-16 |
Immunogen Inc |
"agentes citotóxicos compreendendo derivados de ansamitocina, composição farmacêutica e uso destes"
|
PL2691155T3
(pl)
|
2011-03-29 |
2019-06-28 |
Immunogen, Inc. |
Otrzymywanie koniugatu majtansynoidu przeciwciała jednoetapowym sposobem
|
SG193996A1
(en)
|
2011-03-29 |
2013-11-29 |
Immunogen Inc |
Preparation of maytansinoid antibody conjugates by a one-step process
|
BR112014009050B1
(pt)
|
2011-10-14 |
2022-06-21 |
Medimmune Limited |
Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas
|
LT2907824T
(lt)
|
2012-10-11 |
2018-06-11 |
Daiichi Sankyo Company, Limited |
Antikūno-vaisto konjugatas
|
ES2782248T3
(es)
|
2012-10-19 |
2020-09-11 |
Daiichi Sankyo Co Ltd |
Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila
|
WO2014066002A1
(en)
*
|
2012-10-23 |
2014-05-01 |
The Johns Hopkins University |
Novel self-assembling drug amphiphiles and methods for synthesis and use
|
WO2014093343A2
(en)
|
2012-12-10 |
2014-06-19 |
Massachusetts Institute Of Technology |
Multistage nanoparticle drug delivery system for the treatment of solid tumors
|
JP6494533B2
(ja)
|
2013-02-28 |
2019-04-03 |
イミュノジェン・インコーポレーテッド |
細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体
|
NZ721877A
(en)
|
2013-12-19 |
2022-07-29 |
Seagen Inc |
Methylene carbamate linkers for use with targeted-drug conjugates
|
US20180163271A1
(en)
|
2014-01-16 |
2018-06-14 |
Clovis Oncology, Inc. |
Use of PARP Inhibitors to Treat Breast or Ovarian Cancer Patients Showing a Loss of Heterozygosity
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗cd98抗体−薬物コンジュゲート
|
EP3130608B1
(en)
*
|
2014-04-10 |
2019-09-04 |
Daiichi Sankyo Co., Ltd. |
(anti-her2 antibody)-drug conjugate
|
KR102239413B1
(ko)
|
2014-04-10 |
2021-04-12 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
BR112017000865A2
(pt)
|
2014-08-22 |
2017-12-05 |
Clovis Oncology Inc |
comprimidos de rucaparibe de concentração de dosagem alta
|
US10759860B2
(en)
|
2014-09-16 |
2020-09-01 |
Synermore Biologics Co., Ltd. |
Anti-EGFR antibody and uses of same
|
MA40934A
(fr)
|
2014-11-19 |
2017-09-27 |
Immunogen Inc |
Procédé de préparation de conjugués agent de liaison cellulaire-agent cytotoxique
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
SG11201803686UA
(en)
|
2015-11-24 |
2018-06-28 |
Theravance Biopharma R&D Ip Llc |
Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
|
KR102498258B1
(ko)
|
2016-01-20 |
2023-02-10 |
삼성디스플레이 주식회사 |
표시 장치
|
US20170267727A1
(en)
|
2016-03-04 |
2017-09-21 |
Lehigh University |
Conjugates of pH Low Insertion Peptide and Monomethyl Auristatins in the Treatment of Solid Tumors
|
WO2017156191A1
(en)
|
2016-03-08 |
2017-09-14 |
Los Gatos Pharmaceuticals, Inc. |
Composite nanoparticles and uses thereof
|
WO2017180834A1
(en)
*
|
2016-04-13 |
2017-10-19 |
Tarveda Therapeutics, Inc. |
Neurotensin receptor binding conjugates and formulations thereof
|
GB201608885D0
(en)
|
2016-05-20 |
2016-07-06 |
Univ Birmingham |
Treatment
|
WO2017210608A1
(en)
|
2016-06-02 |
2017-12-07 |
Yale University |
Compositions and methods for targeting and treating homologous recombination-deficient tumors
|
US20210283281A1
(en)
|
2016-07-29 |
2021-09-16 |
Memorial Sloan Kettering Cancer Center |
Radiolabeled ligands for targeted pet/spect imaging and methods of their use
|
MX2019001905A
(es)
|
2016-08-16 |
2019-05-15 |
Aist |
Peptido objetivo de tumor maligno.
|
WO2018057912A1
(en)
|
2016-09-22 |
2018-03-29 |
Rhode Island Council On Postsecondary Education |
FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH -TRIGGERED POLYPEPTIDE
|
WO2018227132A1
(en)
|
2017-06-09 |
2018-12-13 |
Rhode Island Council On Postsecondary Education |
Linked and other ph-triggered compounds
|
JP7248578B2
(ja)
|
2017-08-31 |
2023-03-29 |
第一三共株式会社 |
抗体-薬物コンジュゲートの新規製造方法
|
MX2020007060A
(es)
|
2018-01-05 |
2020-11-11 |
Cybrexa 1 Inc |
Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas.
|
AU2019208024A1
(en)
|
2018-01-12 |
2020-08-13 |
Prolynx Llc |
Protocol for minimizing toxicity of combination dosages and imaging agent for verification
|
KR20210013107A
(ko)
|
2018-05-18 |
2021-02-03 |
다이이찌 산쿄 가부시키가이샤 |
항-muc1 항체-약물 접합체
|
TW202015740A
(zh)
|
2018-06-07 |
2020-05-01 |
美商西雅圖遺傳學公司 |
喜樹鹼結合物
|
CN109232719B
(zh)
|
2018-09-21 |
2021-06-29 |
中国科学院理化技术研究所 |
一种pH响应的抗菌肽及其制备方法和应用
|
WO2020160009A1
(en)
|
2019-01-28 |
2020-08-06 |
Rhode Island Council On Postsecondary Education |
Phlip® targeted delivery of potent cytotoxic compounds
|
PT3946464T
(pt)
|
2019-03-29 |
2022-11-16 |
Medimmune Ltd |
Compostos e seus conjugados
|
CA3146385A1
(en)
|
2019-07-10 |
2021-01-14 |
Cybrexa 3, Inc. |
Peptide conjugates of microtubule-targeting agents as therapeutics
|