JPWO2020017568A1 - アディポネクチン分泌促進剤 - Google Patents
アディポネクチン分泌促進剤 Download PDFInfo
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- JPWO2020017568A1 JPWO2020017568A1 JP2020531349A JP2020531349A JPWO2020017568A1 JP WO2020017568 A1 JPWO2020017568 A1 JP WO2020017568A1 JP 2020531349 A JP2020531349 A JP 2020531349A JP 2020531349 A JP2020531349 A JP 2020531349A JP WO2020017568 A1 JPWO2020017568 A1 JP WO2020017568A1
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Abstract
Description
[1]シマアザミを含有するアディポネクチン分泌促進剤。
[2]シマアザミの乾燥粉末を含有する前記[1]に記載のアディポネクチン分泌促進剤。
[3]前記[1]または[2]に記載のアディポネクチン分泌促進剤を含有するアディポネクチン分泌促進用飲食品。
<試験方法>
(1)被験者
同意取得時の年齢が20歳から80歳までの日本人男性および女性で、LDLコレステロール値が境界域および軽症域(120〜159mg/dL)、または中性脂肪値が正常高値域およびやや高め(120〜199mg/dL)に該当する24名を被験者とした。
シマアザミの葉を水で洗った後、次亜塩素酸で殺菌した。その後、水切りを十分行い、予備凍結させた。次に、真空乾燥装置(株式会社マルイ)を用いてシマアザミの葉を凍結乾燥させた。凍結乾燥させた葉を粉砕機で粉砕し、ふるいにかけて非粉末物を除去し、シマアザミの葉の凍結乾燥粉末を得た。被験者は、1回あたり3gのシマアザミ粉末を1日3回(9g/日)、12週間摂取した。具体的には、1回あたりシマアザミ粉末3gに水(100〜150mL)加えてシマアザミ青汁を用時調製し、飲用した。
・身体測定:身長(初回のみ)、体重、体脂肪率
・一般生化学検査:グルコース、HbA1c、総コレステロール、HDLコレステロール、LDLコレステロール、中性脂肪
・血中アディポネクチン
・遊離脂肪酸
グルコース、HbA1c、総コレステロール、HDLコレステロール、LDLコレステロールおよび中性脂肪は、株式会社LSIメディエンスに測定を依頼した。
アディポネクチンは、ヒトアディポネクチンELISAキット(大塚製薬)を用いて測定した。
遊離脂肪酸は、NEFA C−テストワコー(和光純薬)を用いて測定した。
シマアザミ青汁摂取開始前、摂取4週間後、摂取8週間後、摂取12週間後に、身体測定と採血(8mL)を行い、各項目を測定した。
摂取開始前の測定値を基準として、各時点での測定値を比較し、対応のあるt検定を行った結果を表1に示した(平均値±標準偏差)。体重、BMI、中性脂肪、遊離脂肪酸および空腹時血糖値は変動がなかった。体脂肪率は、摂取開始8週後および12週後に有意に上昇した。総コレステロールは、摂取開始12週後に有意に上昇した。HDLコレステロールは、摂取開始4週後、8週後および12週後に有意に上昇した。LDLコレステロールは、摂取開始8週後および12週後に有意に上昇した。HbA1cは摂取開始4週後および12週後に有意に上昇した。アディポネクチンは、摂取開始8週後および12週後に有意に上昇した。
Claims (3)
- シマアザミを含有するアディポネクチン分泌促進剤。
- シマアザミの乾燥粉末を含有する請求項1に記載のアディポネクチン分泌促進剤。
- 請求項1または2に記載のアディポネクチン分泌促進剤を含有するアディポネクチン分泌促進用飲食品。
Applications Claiming Priority (3)
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JP2018136131 | 2018-07-19 | ||
JP2018136131 | 2018-07-19 | ||
PCT/JP2019/028166 WO2020017568A1 (ja) | 2018-07-19 | 2019-07-17 | アディポネクチン分泌促進剤 |
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JPWO2020017568A1 true JPWO2020017568A1 (ja) | 2021-08-02 |
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US (1) | US20210283207A1 (ja) |
JP (1) | JPWO2020017568A1 (ja) |
CN (1) | CN112804885A (ja) |
WO (1) | WO2020017568A1 (ja) |
Citations (5)
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JP2006273786A (ja) * | 2005-03-30 | 2006-10-12 | Abo Kenji | グループbソヤサポニン類を含む組成物およびその組成物の経口摂取による糖尿病治療・予防方法 |
JP2007320901A (ja) * | 2006-05-31 | 2007-12-13 | Snow Brand Milk Prod Co Ltd | 内臓脂肪蓄積抑制剤及び、血中アディポネクチン濃度増加促進及び/又は減少抑制剤 |
JP2008222664A (ja) * | 2007-03-14 | 2008-09-25 | Noevir Co Ltd | 皮膚外用剤及び食品 |
JP2011168540A (ja) * | 2010-02-19 | 2011-09-01 | Sakamoto Jozo Kk | 抗肥満作用促進剤、アディポネクチン分泌促進又は分泌低下抑制剤 |
WO2015022978A1 (ja) * | 2013-08-13 | 2015-02-19 | 株式会社アミノアップ化学 | 脂肪蓄積抑制剤、医薬品、脂肪肝の予防剤又は治療剤及び飲食品並びに脂肪蓄積抑制剤の製造方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3249707B2 (ja) * | 1995-05-10 | 2002-01-21 | 花王株式会社 | 脂肪分解促進剤 |
JP2008019198A (ja) * | 2006-07-12 | 2008-01-31 | Unitika Ltd | オオアザミ属植物から得られるインスリン抵抗性改善組成物 |
-
2019
- 2019-07-17 CN CN201980048195.8A patent/CN112804885A/zh active Pending
- 2019-07-17 JP JP2020531349A patent/JPWO2020017568A1/ja active Pending
- 2019-07-17 US US17/261,377 patent/US20210283207A1/en not_active Abandoned
- 2019-07-17 WO PCT/JP2019/028166 patent/WO2020017568A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006273786A (ja) * | 2005-03-30 | 2006-10-12 | Abo Kenji | グループbソヤサポニン類を含む組成物およびその組成物の経口摂取による糖尿病治療・予防方法 |
JP2007320901A (ja) * | 2006-05-31 | 2007-12-13 | Snow Brand Milk Prod Co Ltd | 内臓脂肪蓄積抑制剤及び、血中アディポネクチン濃度増加促進及び/又は減少抑制剤 |
JP2008222664A (ja) * | 2007-03-14 | 2008-09-25 | Noevir Co Ltd | 皮膚外用剤及び食品 |
JP2011168540A (ja) * | 2010-02-19 | 2011-09-01 | Sakamoto Jozo Kk | 抗肥満作用促進剤、アディポネクチン分泌促進又は分泌低下抑制剤 |
WO2015022978A1 (ja) * | 2013-08-13 | 2015-02-19 | 株式会社アミノアップ化学 | 脂肪蓄積抑制剤、医薬品、脂肪肝の予防剤又は治療剤及び飲食品並びに脂肪蓄積抑制剤の製造方法 |
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WO2020017568A1 (ja) | 2020-01-23 |
US20210283207A1 (en) | 2021-09-16 |
CN112804885A (zh) | 2021-05-14 |
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