JPWO2013051568A1 - アプリケータ - Google Patents
アプリケータ Download PDFInfo
- Publication number
- JPWO2013051568A1 JPWO2013051568A1 JP2013537516A JP2013537516A JPWO2013051568A1 JP WO2013051568 A1 JPWO2013051568 A1 JP WO2013051568A1 JP 2013537516 A JP2013537516 A JP 2013537516A JP 2013537516 A JP2013537516 A JP 2013537516A JP WO2013051568 A1 JPWO2013051568 A1 JP WO2013051568A1
- Authority
- JP
- Japan
- Prior art keywords
- piston
- applicator
- spring
- transmission member
- microneedle array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
アプリケータ10は、針密度が500本/cm2以上である微小突起(マイクロニードル)を有するマイクロニードルアレイ90に付勢部材の付勢力を伝える伝達部材を備えている。伝達部材の質量は1.5g以下であり、付勢部材の付勢力により作動した伝達部材の運動量は0.0083(Ns)以上0.015(Ns)以下である。
Description
Claims (5)
- 皮膚にマイクロニードルを適用させるためのアプリケータであって、
針密度が500本/cm2以上である前記マイクロニードルを有するマイクロニードルアレイに付勢部材の付勢力を伝える伝達部材を備え、
前記伝達部材の質量が1.5g以下であり、
前記付勢部材の付勢力により作動した前記伝達部材の運動量が0.0083(Ns)以上0.015(Ns)以下である、アプリケータ。 - 前記マイクロニードルに塗布された活性成分の前記皮膚への移行量が前記伝達部材の運動量に比例する、請求項1に記載のアプリケータ。
- 前記付勢部材が弾性部材であり、
前記皮膚に向かって移動する前記伝達部材の移動区間の一部である第1の区間において、該伝達部材が前記弾性部材の付勢力を受けることなく移動する、請求項1又は2に記載のアプリケータ。 - 前記弾性部材を支持するとともに、前記第1の区間とは異なる第2の区間において前記付勢力を前記伝達部材に伝える支持台をさらに備え、
前記付勢力により前記伝達部材を押していた前記支持台が前記第2の区間の一端において止まることで、該伝達部材が前記第1の区間において前記付勢力を受けることなく移動する、請求項3に記載のアプリケータ。 - 前記付勢部材は円柱コイルばねである、請求項1〜4のいずれか一項に記載のアプリケータ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011222236 | 2011-10-06 | ||
JP2011222236 | 2011-10-06 | ||
PCT/JP2012/075534 WO2013051568A1 (ja) | 2011-10-06 | 2012-10-02 | アプリケータ |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2013051568A1 true JPWO2013051568A1 (ja) | 2015-03-30 |
JP6265740B2 JP6265740B2 (ja) | 2018-01-24 |
Family
ID=48043725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013537516A Active JP6265740B2 (ja) | 2011-10-06 | 2012-10-02 | アプリケータ |
Country Status (5)
Country | Link |
---|---|
US (1) | US9498611B2 (ja) |
EP (1) | EP2764887B1 (ja) |
JP (1) | JP6265740B2 (ja) |
TW (1) | TW201330893A (ja) |
WO (1) | WO2013051568A1 (ja) |
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US9943673B2 (en) | 2010-07-14 | 2018-04-17 | Vaxxas Pty Limited | Patch applying apparatus |
AU2012323782B2 (en) | 2011-10-12 | 2017-04-06 | Vaxxas Pty Limited | Delivery device |
CN104245041B (zh) * | 2012-04-05 | 2016-08-17 | 久光制药株式会社 | 穿刺装置及其制造方法 |
CN104955517B (zh) | 2012-12-21 | 2017-09-26 | 久光制药株式会社 | 施放器 |
SG11201509722PA (en) * | 2013-05-31 | 2015-12-30 | 3M Innovative Properties Co | Microneedle injection apparatus comprising a dual cover |
KR102349218B1 (ko) * | 2013-08-09 | 2022-01-10 | 사이트렐리스 바이오시스템즈, 인크. | 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구 |
WO2015040697A1 (ja) * | 2013-09-18 | 2015-03-26 | コスメディ製薬株式会社 | マイクロニードルパッチ適用装置及びパッチホルダー |
US10086183B2 (en) | 2013-11-05 | 2018-10-02 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
EP3217899A4 (en) | 2014-11-14 | 2018-07-11 | Cytrellis Biosystems, Inc. | Devices and methods for ablation of the skin |
US11147954B2 (en) | 2015-02-02 | 2021-10-19 | Vaxxas Pty Limited | Microprojection array applicator and method |
JP2017023404A (ja) | 2015-07-22 | 2017-02-02 | 日本写真印刷株式会社 | マイクロニードルパッチ用インパクト付加型アプリケータ及び先端部材 |
EP3345648A4 (en) * | 2015-09-02 | 2019-04-17 | Hisamitsu Pharmaceutical Co., Inc. | APPLICATOR |
WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
CA2999538A1 (en) * | 2015-09-28 | 2017-04-06 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
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AU2018309562A1 (en) | 2017-08-04 | 2020-02-20 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
US10945759B2 (en) | 2017-12-28 | 2021-03-16 | Refine Usa, Llc | Microneedle device |
JP7099189B2 (ja) * | 2018-08-30 | 2022-07-12 | ニプロ株式会社 | マイクロニードルアプリケータ |
JP7172293B2 (ja) * | 2018-08-30 | 2022-11-16 | ニプロ株式会社 | マイクロニードルアプリケータ |
KR20210086599A (ko) * | 2018-08-30 | 2021-07-08 | 니프로 가부시키가이샤 | 마이크로 니들 어플리케이터 |
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USD1031036S1 (en) * | 2021-12-08 | 2024-06-11 | Guangzhou Ekai Electronic Technology Co., Ltd. | Microneedling pen |
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2012
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- 2012-10-04 TW TW101136676A patent/TW201330893A/zh unknown
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Also Published As
Publication number | Publication date |
---|---|
EP2764887A1 (en) | 2014-08-13 |
EP2764887A4 (en) | 2015-12-09 |
JP6265740B2 (ja) | 2018-01-24 |
TW201330893A (zh) | 2013-08-01 |
TWI561272B (ja) | 2016-12-11 |
US9498611B2 (en) | 2016-11-22 |
US20140243747A1 (en) | 2014-08-28 |
EP2764887B1 (en) | 2020-12-02 |
WO2013051568A1 (ja) | 2013-04-11 |
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