JPS5724376A - Novel morpholine derivative and its preparation - Google Patents

Novel morpholine derivative and its preparation

Info

Publication number
JPS5724376A
JPS5724376A JP9920480A JP9920480A JPS5724376A JP S5724376 A JPS5724376 A JP S5724376A JP 9920480 A JP9920480 A JP 9920480A JP 9920480 A JP9920480 A JP 9920480A JP S5724376 A JPS5724376 A JP S5724376A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
halogen
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9920480A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Toshimitsu Shigeari
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP9920480A priority Critical patent/JPS5724376A/en
Publication of JPS5724376A publication Critical patent/JPS5724376A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

NEW MATERIAL:4-Isopropyl-6-hydroxymethyl-morpholino-2,3-dione of formula I.
USE: An intermediate for the preparation of pharmaceuticals. A reagent for introducing the side group to obtain a drug having 3-isopropylamino-2-hydroxy-propoxy group as a side chain and useful as a β-receptor blocking agent (e.g. pindolol), or its intermediate.
PROCESS: The compound of formula I is prepared by reacting the compound of formula II with the compound of formula III (R is halogen or lower alkoxy) at room temp. W150°C for 15min W 15hr. The reaction is pref. carried out in an inert solvent such as xylene, toluene, benzene, etc. when the R in the formula III is halogen, and in the absence of solvent when the R is lower alkoxy.
COPYRIGHT: (C)1982,JPO&Japio
JP9920480A 1980-07-18 1980-07-18 Novel morpholine derivative and its preparation Pending JPS5724376A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9920480A JPS5724376A (en) 1980-07-18 1980-07-18 Novel morpholine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9920480A JPS5724376A (en) 1980-07-18 1980-07-18 Novel morpholine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5724376A true JPS5724376A (en) 1982-02-08

Family

ID=14241113

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9920480A Pending JPS5724376A (en) 1980-07-18 1980-07-18 Novel morpholine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5724376A (en)

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