JPS57139065A - Preparation of omega-indole-3-ylalkanole compound - Google Patents
Preparation of omega-indole-3-ylalkanole compoundInfo
- Publication number
- JPS57139065A JPS57139065A JP2351481A JP2351481A JPS57139065A JP S57139065 A JPS57139065 A JP S57139065A JP 2351481 A JP2351481 A JP 2351481A JP 2351481 A JP2351481 A JP 2351481A JP S57139065 A JPS57139065 A JP S57139065A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- indole
- alkyl
- strong acid
- compound shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a raw material for synthesizing drugs, etc. economically, by reacting a strong acid salt of a phenylhydrazine compound with an oxacycloalkane-2-ol compound in an alcoholic type solvent.
CONSTITUTION: A strong acid salt of phenylhydrazine compound shown by the formulaI(R1 is H, alkyl, aryl, alalkyl; R2 is H, alkyl, aryl, alalkyl, alkoxyl, aryloxyl, alalkoxyl, halogen; R3 is H, alkyl) is reacted with an oxacycloalkane- 2-ol compound (preferably tetrahydrofuran ring, tetrahydropyran ring) shown by the formula II (n is 0 or 1) in an alcoholic type solvent preferably at 70W170°C, to give a compound shown by the formula III. The amount of the strong acid of the compound shown by the formulaIis preferably 1.3W3.0 times as much as that of the compound shown by the formula II.
USE: A raw material for indole derivatives, indole alkaloid derivatives, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2351481A JPS57139065A (en) | 1981-02-19 | 1981-02-19 | Preparation of omega-indole-3-ylalkanole compound |
BE0/207318A BE892145A (en) | 1981-02-19 | 1982-02-15 | PROCESS FOR THE PREPARATION OF OMEGA-INDOL-3-YL-ALKANOL COMPOUNDS |
DE19823205388 DE3205388A1 (en) | 1981-02-19 | 1982-02-16 | Process for the preparation of omega -indol-3-ylalkanols |
FR8203178A FR2499987B1 (en) | 1981-02-19 | 1982-02-17 | PROCESS FOR THE PREPARATION OF O-INDOL-3-YL-ALKANOL COMPOUNDS |
HU49782A HU186036B (en) | 1981-02-19 | 1982-02-18 | Process for producing omega-indol-3-yl-alkanol derivatives |
CH1017/82A CH648018A5 (en) | 1981-02-19 | 1982-02-18 | METHOD FOR PRODUCING OMEGA-INDOL-3-YL-ALKANOL COMPOUNDS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2351481A JPS57139065A (en) | 1981-02-19 | 1981-02-19 | Preparation of omega-indole-3-ylalkanole compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57139065A true JPS57139065A (en) | 1982-08-27 |
JPH0148267B2 JPH0148267B2 (en) | 1989-10-18 |
Family
ID=12112550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2351481A Granted JPS57139065A (en) | 1981-02-19 | 1981-02-19 | Preparation of omega-indole-3-ylalkanole compound |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS57139065A (en) |
BE (1) | BE892145A (en) |
CH (1) | CH648018A5 (en) |
DE (1) | DE3205388A1 (en) |
FR (1) | FR2499987B1 (en) |
HU (1) | HU186036B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114763A (en) * | 2000-10-11 | 2002-04-16 | Meiji Milk Prod Co Ltd | Indole long-chain alcohol and medicine containing the same |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133453A (en) * | 1998-05-15 | 2000-10-17 | Pharm-Eco Laboratories, Inc. | Method for making substituted indoles |
US7407983B2 (en) | 2002-02-13 | 2008-08-05 | Meiji Dairies Corporation | Indole derivatives substituted with long-chain alcohols and medicaments containing them |
-
1981
- 1981-02-19 JP JP2351481A patent/JPS57139065A/en active Granted
-
1982
- 1982-02-15 BE BE0/207318A patent/BE892145A/en not_active IP Right Cessation
- 1982-02-16 DE DE19823205388 patent/DE3205388A1/en active Granted
- 1982-02-17 FR FR8203178A patent/FR2499987B1/en not_active Expired
- 1982-02-18 HU HU49782A patent/HU186036B/en not_active IP Right Cessation
- 1982-02-18 CH CH1017/82A patent/CH648018A5/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002114763A (en) * | 2000-10-11 | 2002-04-16 | Meiji Milk Prod Co Ltd | Indole long-chain alcohol and medicine containing the same |
JP4745491B2 (en) * | 2000-10-11 | 2011-08-10 | 株式会社明治 | Indole long-chain alcohol and medicine containing the same |
Also Published As
Publication number | Publication date |
---|---|
DE3205388A1 (en) | 1982-09-23 |
FR2499987A1 (en) | 1982-08-20 |
JPH0148267B2 (en) | 1989-10-18 |
BE892145A (en) | 1982-05-27 |
HU186036B (en) | 1985-05-28 |
DE3205388C2 (en) | 1988-10-06 |
FR2499987B1 (en) | 1985-09-13 |
CH648018A5 (en) | 1985-02-28 |
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