JPS57167964A - Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative - Google Patents

Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Info

Publication number
JPS57167964A
JPS57167964A JP56052464A JP5246481A JPS57167964A JP S57167964 A JPS57167964 A JP S57167964A JP 56052464 A JP56052464 A JP 56052464A JP 5246481 A JP5246481 A JP 5246481A JP S57167964 A JPS57167964 A JP S57167964A
Authority
JP
Japan
Prior art keywords
substituted
formula
azetidinone derivative
preparation
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56052464A
Other languages
Japanese (ja)
Inventor
Shuntaro Takano
Isamu Takakura
Yuichi Ochiai
Kiyoshi Tanaka
Tetsuo Santo
Miwako Komatsu
Isamu Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP56052464A priority Critical patent/JPS57167964A/en
Publication of JPS57167964A publication Critical patent/JPS57167964A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals, in one step, in high yield, by reacting a (4S)-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative with a specific reaction reagent in the presence of a base.
CONSTITUTION: The objective compound of formula III[R1 is H, salt-forming cation, etc.; R2 is protecting group; R7 is group of formula -COR6 or -CR5R9R10 (R5 is alkyl, etc.; R6 is H, etc.; R9 and R10 are H, alkyl, etc.; R9 and R10 may together with adjacent C atom form a salt)]can be prepared by reactig a (4S)-4- (substituted or unsubstituted carboxymethyl)-2-azetidinone derivative of formulaI with a reaction reagent selected from the compounds of formula II, formula R5X (X is reactive group) and formula R6COY (Y is reactive group), in the presence of a base, and if necessary, eliminating or introducing or chlorinating the carboxyl protecting group of R1.
COPYRIGHT: (C)1982,JPO&Japio
JP56052464A 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative Pending JPS57167964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56052464A JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56052464A JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Publications (1)

Publication Number Publication Date
JPS57167964A true JPS57167964A (en) 1982-10-16

Family

ID=12915434

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56052464A Pending JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Country Status (1)

Country Link
JP (1) JPS57167964A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118566A (en) * 1981-12-30 1983-07-14 リヒテル・ゲデオン・ベギエスゼテイ・ギアル・ア−ル・テイ− Novel heterocyclic acetic acid derivative and manufacture
JPS58118564A (en) * 1981-12-30 1983-07-14 リヒテル・ゲデオン・ベギエスゼテイ・ギヤル・ア−ル・テイ− Novel heterocyclic acetic acid derivative
JPS5946265A (en) * 1982-08-24 1984-03-15 Sankyo Co Ltd Azetidinone derivative and its preparation
FR2549052A1 (en) * 1983-06-23 1985-01-18 Richter Gedeon Vegyeszet DIASTEREOMERIC DERIVATIVES OF 4-OXO-2 AZETIDINYL-ACETIC ACID

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108785A (en) * 1979-04-27 1981-08-28 Merck & Co Inc Manufacture of 33*11hydroxyethyl**azetidinone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108785A (en) * 1979-04-27 1981-08-28 Merck & Co Inc Manufacture of 33*11hydroxyethyl**azetidinone

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118566A (en) * 1981-12-30 1983-07-14 リヒテル・ゲデオン・ベギエスゼテイ・ギアル・ア−ル・テイ− Novel heterocyclic acetic acid derivative and manufacture
JPS58118564A (en) * 1981-12-30 1983-07-14 リヒテル・ゲデオン・ベギエスゼテイ・ギヤル・ア−ル・テイ− Novel heterocyclic acetic acid derivative
JPS5946265A (en) * 1982-08-24 1984-03-15 Sankyo Co Ltd Azetidinone derivative and its preparation
JPH0129185B2 (en) * 1982-08-24 1989-06-08 Sankyo Co
FR2549052A1 (en) * 1983-06-23 1985-01-18 Richter Gedeon Vegyeszet DIASTEREOMERIC DERIVATIVES OF 4-OXO-2 AZETIDINYL-ACETIC ACID
JPS6056955A (en) * 1983-06-23 1985-04-02 リヒター　ゲデオン　ベジエセテイ　ジヤール　アール．テー． Heterocyclic acetic acid ester

Similar Documents

Publication Publication Date Title
CA2046482A1 (en) Process for the preparation of an n-phenylacetic derivative of tetrahydrothieno [3,2-c] pyridine and its chemical intermediate
CA2090967A1 (en) Water soluble camptothecin analogues, processes and methods
JPS56131565A (en) 4-substituted-2-oxoazetidine compound and its preparation
PT77712A (en) Process for preparing penem compounds
JPS57167964A (en) Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative
ES2016017A6 (en) 1,1-dioxo-cephem-4-carbothiolic acid derivatives.
JPS56104890A (en) Preparation of organosilane
JPS57163369A (en) Novel geldanamycin derivative, its preparation, and drug comprising it as active ingredient
DE3268574D1 (en) Process for the production of quinoline containing heterocycles, intermediates, and process for the production of the intermediates
JPS57146786A (en) Optically active borane compound and preparation of optically active compound using the same
JPS57144269A (en) Triazine derivative and its preparation
JPS57183768A (en) 4-methyl-5-(o-carboxyphenyl)carbamoylthiazole derivative and its preparation
JPS57192340A (en) Isoprenylamine derivative
JPS5772981A (en) 1,8-naphthyridine derivative and its salt
JPS56156263A (en) Carbostyril derivative
JPS57175186A (en) Novel vitamin e derivative and its preparation
JPS5759897A (en) Thiazolineazatidinone
JPS5721400A (en) Novel fortimicin derivative
JPS57149289A (en) Thiazinobenzoazepin derivative
JPS5555160A (en) Preparation of substituted benzamide
JPS57116048A (en) Novel quinoline derivative
JPS5592363A (en) New 2-azetidinone derivative
JPS5759887A (en) Production of dibenzothiepinpropionamide derivative
JPS5651450A (en) Halogen-substituted proline derivative and its preparation
JPS5653670A (en) 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component