JPS56100766A - Novel geldanamycin derivative, its preparation, and antitumor agent containing said compound as effective component - Google Patents
Novel geldanamycin derivative, its preparation, and antitumor agent containing said compound as effective componentInfo
- Publication number
- JPS56100766A JPS56100766A JP311980A JP311980A JPS56100766A JP S56100766 A JPS56100766 A JP S56100766A JP 311980 A JP311980 A JP 311980A JP 311980 A JP311980 A JP 311980A JP S56100766 A JPS56100766 A JP S56100766A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- antitumor agent
- preparation
- geldanamycin derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A geldanamycin derivative of formula I(R is halogen).
EXAMPLE: 19-Bromogeldanamycin.
USE: The compound has remarkable effect to suppress the growth of experimental tumor cell W-2K-11 which has been widely recognized as a model of cancer cell, and is useful as an antitumor agent. Dose: usually 0.5W80mg/kg daily for adult by parenteral administration, and 1W100mg/kg by oral administration. It is also useful as an intermediate for the synthesis of other derivatives.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II with a halogenating agent such as pyridinium bromide perbromide, iodine- pyridine, etc. in an organic solvent such as ethanol-chloroform mixture, etc. at 0W100°C, and if necessary, treating the product with a chloride.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP311980A JPS56100766A (en) | 1980-01-17 | 1980-01-17 | Novel geldanamycin derivative, its preparation, and antitumor agent containing said compound as effective component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP311980A JPS56100766A (en) | 1980-01-17 | 1980-01-17 | Novel geldanamycin derivative, its preparation, and antitumor agent containing said compound as effective component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56100766A true JPS56100766A (en) | 1981-08-12 |
Family
ID=11548462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP311980A Pending JPS56100766A (en) | 1980-01-17 | 1980-01-17 | Novel geldanamycin derivative, its preparation, and antitumor agent containing said compound as effective component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56100766A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US7241754B2 (en) | 2003-06-13 | 2007-07-10 | Kosan Biosciences, Inc. | 2-Desmethyl ansamycin compounds |
-
1980
- 1980-01-17 JP JP311980A patent/JPS56100766A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| J.ANTIBIOT=1979 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US7405208B2 (en) | 2001-08-06 | 2008-07-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US7241754B2 (en) | 2003-06-13 | 2007-07-10 | Kosan Biosciences, Inc. | 2-Desmethyl ansamycin compounds |
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