JPS57126415A - Preparation of prolonged release type composite - Google Patents
Preparation of prolonged release type compositeInfo
- Publication number
- JPS57126415A JPS57126415A JP1067481A JP1067481A JPS57126415A JP S57126415 A JPS57126415 A JP S57126415A JP 1067481 A JP1067481 A JP 1067481A JP 1067481 A JP1067481 A JP 1067481A JP S57126415 A JPS57126415 A JP S57126415A
- Authority
- JP
- Japan
- Prior art keywords
- release type
- type composite
- prolonged
- prolonged release
- physiologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain a prolonged release type composite having prolonged releasability of a physiologically active substance, by treating a system containing the physiologically active substance and a mixture of a polypeptide with a protein as a matrix under pressure.
CONSTITUTION: A system consisting of one or two or more polypeptides, e.g. poly-alanine or poly-glycine, one or two or more proteins and one or two or more physiologically active substances, e.g. bleomycin hydrochloride or mitomycin C, is mechanically pulverized and mixed in a frozen state, molded into a suitable form and irradiated with light or inonizing radiation, e.g. gamma rays from a cobalt 60 source, under a pressure of 100W20,000kg/cm2 or after the pressurizing to give a prolonged release type composite. The polypeptide finely pulverized and pressurized at a low temperature has the tackiness and improved properties as a membrane, but the protein has more tackiness and provides the composite having improved prolonged releasability by the presence of both.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1067481A JPS57126415A (en) | 1981-01-27 | 1981-01-27 | Preparation of prolonged release type composite |
US06/340,989 US4483807A (en) | 1981-01-27 | 1982-01-20 | Process for producing a slow release composite |
DE3249683A DE3249683C2 (en) | 1981-01-27 | 1982-01-25 | Method of making a composite with long-term release |
DE3249684A DE3249684C2 (en) | 1981-01-27 | 1982-01-25 | |
DE19823202255 DE3202255A1 (en) | 1981-01-27 | 1982-01-25 | METHOD FOR PRODUCING A COMPOSITE WITH LONG-TERM RELEASE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1067481A JPS57126415A (en) | 1981-01-27 | 1981-01-27 | Preparation of prolonged release type composite |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57126415A true JPS57126415A (en) | 1982-08-06 |
JPS6150928B2 JPS6150928B2 (en) | 1986-11-06 |
Family
ID=11756798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1067481A Granted JPS57126415A (en) | 1981-01-27 | 1981-01-27 | Preparation of prolonged release type composite |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57126415A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011692A (en) * | 1985-12-28 | 1991-04-30 | Sumitomo Pharmaceuticals Company, Limited | Sustained pulsewise release pharmaceutical preparation |
-
1981
- 1981-01-27 JP JP1067481A patent/JPS57126415A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011692A (en) * | 1985-12-28 | 1991-04-30 | Sumitomo Pharmaceuticals Company, Limited | Sustained pulsewise release pharmaceutical preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS6150928B2 (en) | 1986-11-06 |
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