JPS57126415A - Preparation of prolonged release type composite - Google Patents

Preparation of prolonged release type composite

Info

Publication number
JPS57126415A
JPS57126415A JP1067481A JP1067481A JPS57126415A JP S57126415 A JPS57126415 A JP S57126415A JP 1067481 A JP1067481 A JP 1067481A JP 1067481 A JP1067481 A JP 1067481A JP S57126415 A JPS57126415 A JP S57126415A
Authority
JP
Japan
Prior art keywords
release type
type composite
prolonged
prolonged release
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1067481A
Other languages
Japanese (ja)
Other versions
JPS6150928B2 (en
Inventor
Masaharu Asano
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP1067481A priority Critical patent/JPS57126415A/en
Priority to US06/340,989 priority patent/US4483807A/en
Priority to DE3249683A priority patent/DE3249683C2/en
Priority to DE3249684A priority patent/DE3249684C2/de
Priority to DE19823202255 priority patent/DE3202255A1/en
Publication of JPS57126415A publication Critical patent/JPS57126415A/en
Publication of JPS6150928B2 publication Critical patent/JPS6150928B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain a prolonged release type composite having prolonged releasability of a physiologically active substance, by treating a system containing the physiologically active substance and a mixture of a polypeptide with a protein as a matrix under pressure.
CONSTITUTION: A system consisting of one or two or more polypeptides, e.g. poly-alanine or poly-glycine, one or two or more proteins and one or two or more physiologically active substances, e.g. bleomycin hydrochloride or mitomycin C, is mechanically pulverized and mixed in a frozen state, molded into a suitable form and irradiated with light or inonizing radiation, e.g. gamma rays from a cobalt 60 source, under a pressure of 100W20,000kg/cm2 or after the pressurizing to give a prolonged release type composite. The polypeptide finely pulverized and pressurized at a low temperature has the tackiness and improved properties as a membrane, but the protein has more tackiness and provides the composite having improved prolonged releasability by the presence of both.
COPYRIGHT: (C)1982,JPO&Japio
JP1067481A 1981-01-27 1981-01-27 Preparation of prolonged release type composite Granted JPS57126415A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP1067481A JPS57126415A (en) 1981-01-27 1981-01-27 Preparation of prolonged release type composite
US06/340,989 US4483807A (en) 1981-01-27 1982-01-20 Process for producing a slow release composite
DE3249683A DE3249683C2 (en) 1981-01-27 1982-01-25 Method of making a composite with long-term release
DE3249684A DE3249684C2 (en) 1981-01-27 1982-01-25
DE19823202255 DE3202255A1 (en) 1981-01-27 1982-01-25 METHOD FOR PRODUCING A COMPOSITE WITH LONG-TERM RELEASE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1067481A JPS57126415A (en) 1981-01-27 1981-01-27 Preparation of prolonged release type composite

Publications (2)

Publication Number Publication Date
JPS57126415A true JPS57126415A (en) 1982-08-06
JPS6150928B2 JPS6150928B2 (en) 1986-11-06

Family

ID=11756798

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1067481A Granted JPS57126415A (en) 1981-01-27 1981-01-27 Preparation of prolonged release type composite

Country Status (1)

Country Link
JP (1) JPS57126415A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011692A (en) * 1985-12-28 1991-04-30 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011692A (en) * 1985-12-28 1991-04-30 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation

Also Published As

Publication number Publication date
JPS6150928B2 (en) 1986-11-06

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