JPS56115713A - Preparation of slow-releasing complex - Google Patents

Preparation of slow-releasing complex

Info

Publication number
JPS56115713A
JPS56115713A JP1942080A JP1942080A JPS56115713A JP S56115713 A JPS56115713 A JP S56115713A JP 1942080 A JP1942080 A JP 1942080A JP 1942080 A JP1942080 A JP 1942080A JP S56115713 A JPS56115713 A JP S56115713A
Authority
JP
Japan
Prior art keywords
slow
bioactive substance
protein
bioactive
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1942080A
Other languages
Japanese (ja)
Inventor
Isao Kaetsu
Masaharu Asano
Minoru Kumakura
Masaru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Atomic Energy Agency
Original Assignee
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Atomic Energy Research Institute filed Critical Japan Atomic Energy Research Institute
Priority to JP1942080A priority Critical patent/JPS56115713A/en
Priority to DE3104815A priority patent/DE3104815C2/en
Publication of JPS56115713A publication Critical patent/JPS56115713A/en
Priority to US06/514,026 priority patent/US4582719A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To prepare slow-releasing complex, by denaturating a system consisting of an aqueous solution of a bioactive substance and a protein as a whole, thereby dispersing a sufficiently large amount of the bioactive substance in the coagulated protein.
CONSTITUTION: One or more bioactive substances (e.g. 5-fluorouracil, insulin, etc.) are brought into contact with one or more proteins (e.g. serum albumin, γ-globulin, etc.) in an aqueous solution, and treated physically or chemically (e.g. heating in a water-bath at 80W90°C for a short time) to denaturate the proteins. By this process, a slow-release complex composed of a bioactive substance dispersed and included in a denaturated protein matrix can be obtained. The process affords the inclusion of a sufficiently large amount of the bioactive substance, and enables the release of the substance slowly for a long period when administered to a living body.
COPYRIGHT: (C)1981,JPO&Japio
JP1942080A 1980-02-13 1980-02-19 Preparation of slow-releasing complex Pending JPS56115713A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP1942080A JPS56115713A (en) 1980-02-19 1980-02-19 Preparation of slow-releasing complex
DE3104815A DE3104815C2 (en) 1980-02-13 1981-02-11 Method of making a composite with long-term release
US06/514,026 US4582719A (en) 1980-02-13 1983-07-15 Process for producing a slow release composite

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1942080A JPS56115713A (en) 1980-02-19 1980-02-19 Preparation of slow-releasing complex

Publications (1)

Publication Number Publication Date
JPS56115713A true JPS56115713A (en) 1981-09-11

Family

ID=11998761

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1942080A Pending JPS56115713A (en) 1980-02-13 1980-02-19 Preparation of slow-releasing complex

Country Status (1)

Country Link
JP (1) JPS56115713A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58170711A (en) * 1982-03-31 1983-10-07 Japan Atom Energy Res Inst Production of gradually releasing composite
JPS58225008A (en) * 1982-06-25 1983-12-27 Japan Atom Energy Res Inst Preparation of prolonged action compounded substance
JPS5962519A (en) * 1982-07-02 1984-04-10 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド Nystatin composition
JPS6084213A (en) * 1983-10-14 1985-05-13 Sumitomo Chem Co Ltd Sustained release type anti-inflammatory and analgesic pharmaceutical
JPS60136509A (en) * 1983-12-26 1985-07-20 Japan Atom Energy Res Inst Slow-releasing composite having sandwich structure and its preparation
JPS61236729A (en) * 1985-04-11 1986-10-22 Sumitomo Seiyaku Kk Slow-releasing agent
WO1988006457A1 (en) * 1987-03-04 1988-09-07 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
JP2013501789A (en) * 2009-08-10 2013-01-17 ナノパツクス・フアーマ・エル・エル・シー Drug delivery method using unfolding and folding of protein and peptide nanoparticles

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58170711A (en) * 1982-03-31 1983-10-07 Japan Atom Energy Res Inst Production of gradually releasing composite
JPS58225008A (en) * 1982-06-25 1983-12-27 Japan Atom Energy Res Inst Preparation of prolonged action compounded substance
JPS5962519A (en) * 1982-07-02 1984-04-10 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド Nystatin composition
JPS6084213A (en) * 1983-10-14 1985-05-13 Sumitomo Chem Co Ltd Sustained release type anti-inflammatory and analgesic pharmaceutical
JPS60136509A (en) * 1983-12-26 1985-07-20 Japan Atom Energy Res Inst Slow-releasing composite having sandwich structure and its preparation
JPH0129165B2 (en) * 1983-12-26 1989-06-08 Japan Atomic Energy Res Inst
JPS61236729A (en) * 1985-04-11 1986-10-22 Sumitomo Seiyaku Kk Slow-releasing agent
WO1988006457A1 (en) * 1987-03-04 1988-09-07 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
JP2013501789A (en) * 2009-08-10 2013-01-17 ナノパツクス・フアーマ・エル・エル・シー Drug delivery method using unfolding and folding of protein and peptide nanoparticles
US9066870B2 (en) 2009-08-11 2015-06-30 Nanjing University Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles

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