JPS5686152A - Preparation of n-mercaptoacylamino acid - Google Patents
Preparation of n-mercaptoacylamino acidInfo
- Publication number
- JPS5686152A JPS5686152A JP16237779A JP16237779A JPS5686152A JP S5686152 A JPS5686152 A JP S5686152A JP 16237779 A JP16237779 A JP 16237779A JP 16237779 A JP16237779 A JP 16237779A JP S5686152 A JPS5686152 A JP S5686152A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- metal hydrosulfide
- polar
- salt
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound in high yield without preparing undesirable sulfides as by-products, by converting an N-halogen-substituted acylamino acid or its salt into a thiol with an inexpensive alkali metal hydrosulfide in a polar nonproton solven.
CONSTITUTION: An N-halogen-substituted acylaminoacid shown by the formula I [X is halogen; R is H or CH3; Y is O, S, SO, SO2(CH2)m(m=1 or 2); (n) is 1W3] or its salt is reacted with an alkali metal hydrosulfide or alkaline earth metal hydrosulfide in a polar nonproton solvent (e.g., N,N-dimethylformamide, etc.) to give the desired compound [e.g., 1-(3-mercapto-2-D-methylpropanoyl)-L-proline, etc.] shown by the formula II.
EFFECT: Racemization will not occur at all under heating at 40W60°C.
USE: A hypotensor, etc.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16237779A JPS5686152A (en) | 1979-12-13 | 1979-12-13 | Preparation of n-mercaptoacylamino acid |
GB8038469A GB2065643B (en) | 1979-12-13 | 1980-12-01 | Optically active n-mercaptoalkanoylamino acids |
KR1019800004650A KR840001751B1 (en) | 1979-12-13 | 1980-12-06 | Process for preparation of optically active n-mercaptoalkanoylamino acids |
DE19803046271 DE3046271A1 (en) | 1979-12-13 | 1980-12-09 | METHOD FOR PRODUCING OPTICALLY ACTIVE N-MERCAPTOALKANOYLAMINO ACIDS |
US06/214,780 US4371699A (en) | 1979-12-13 | 1980-12-09 | Process for preparation of optically active N-mercaptoalkanoylamino acids |
FR8026234A FR2471975B1 (en) | 1979-12-13 | 1980-12-10 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDS |
IT50342/80A IT1188971B (en) | 1979-12-13 | 1980-12-11 | PROCEDURE FOR PREPARING OPTICALLY ACTIVE N-MERCAPTOALCANOYL-AMINO ACIDS |
SU803220197A SU1060106A3 (en) | 1979-12-13 | 1980-12-12 | Process for preparing optically active n-mercaptoalkanoylamino acids |
NL8006768A NL192264C (en) | 1979-12-13 | 1980-12-12 | Process for preparing optically active N-mercaptoalkanoylamino acids. |
IE2603/80A IE50548B1 (en) | 1979-12-13 | 1980-12-12 | Process for preparation of optically active n-mercaptoalkanoylamino acids |
ES497665A ES8200863A1 (en) | 1979-12-13 | 1980-12-12 | Process for preparation of optically active N-mercaptoalkanoylamino acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16237779A JPS5686152A (en) | 1979-12-13 | 1979-12-13 | Preparation of n-mercaptoacylamino acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5686152A true JPS5686152A (en) | 1981-07-13 |
JPS6340185B2 JPS6340185B2 (en) | 1988-08-10 |
Family
ID=15753410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16237779A Granted JPS5686152A (en) | 1979-12-13 | 1979-12-13 | Preparation of n-mercaptoacylamino acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5686152A (en) |
-
1979
- 1979-12-13 JP JP16237779A patent/JPS5686152A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6340185B2 (en) | 1988-08-10 |
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