JPS5639087A - Uracil derivative and its preparation - Google Patents

Uracil derivative and its preparation

Info

Publication number
JPS5639087A
JPS5639087A JP11561179A JP11561179A JPS5639087A JP S5639087 A JPS5639087 A JP S5639087A JP 11561179 A JP11561179 A JP 11561179A JP 11561179 A JP11561179 A JP 11561179A JP S5639087 A JPS5639087 A JP S5639087A
Authority
JP
Japan
Prior art keywords
formula
compound
furanyl
fluorouracil
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11561179A
Other languages
Japanese (ja)
Other versions
JPS611031B2 (en
Inventor
Shuichi Ueda
Sanji Yasumoto
Sadao Hashimoto
Setsuo Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP11561179A priority Critical patent/JPS5639087A/en
Publication of JPS5639087A publication Critical patent/JPS5639087A/en
Publication of JPS611031B2 publication Critical patent/JPS611031B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A uracil derivative expressed by formula I (R is lower alkyl or aryl).
EXAMPLE: 1-(3'-Acetoxytetrahydro-2'-furanyl)-5-fluorouracil.
USE: Acarcinostatic agent and a synthetic intermediate therefor.
PROCESS: A 2, 3'-anhydro-1-(tetrahydro-2'-furanyl)-5-fluorouracil of formula II is reacted with an alkali metal salt of an organic acid, e.g. potassium acetate, or an alkali metal halide, e.g. potassium fluoride, and an organic acid, e.g. RCOOH (R is lower alkyl or aryl), in a solvent, e.g. dimethylformamide, at room, temperatureW 250°C to give the compound of formula I. The starting compound of formula II is obtained by dissolving a compound of formula III (X is halogen) in a solvent, e.g. or acetonitrile, and allowing the resultant solution to stand.
COPYRIGHT: (C)1981,JPO&Japio
JP11561179A 1979-09-07 1979-09-07 Uracil derivative and its preparation Granted JPS5639087A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11561179A JPS5639087A (en) 1979-09-07 1979-09-07 Uracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11561179A JPS5639087A (en) 1979-09-07 1979-09-07 Uracil derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5639087A true JPS5639087A (en) 1981-04-14
JPS611031B2 JPS611031B2 (en) 1986-01-13

Family

ID=14666926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11561179A Granted JPS5639087A (en) 1979-09-07 1979-09-07 Uracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5639087A (en)

Also Published As

Publication number Publication date
JPS611031B2 (en) 1986-01-13

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