JPS5649364A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS5649364A
JPS5649364A JP12556779A JP12556779A JPS5649364A JP S5649364 A JPS5649364 A JP S5649364A JP 12556779 A JP12556779 A JP 12556779A JP 12556779 A JP12556779 A JP 12556779A JP S5649364 A JPS5649364 A JP S5649364A
Authority
JP
Japan
Prior art keywords
compound
formula
halogen
reaction
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12556779A
Other languages
Japanese (ja)
Other versions
JPS628117B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12556779A priority Critical patent/JPS5649364A/en
Publication of JPS5649364A publication Critical patent/JPS5649364A/en
Publication of JPS628117B2 publication Critical patent/JPS628117B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I (R1 is H or lower alkyl; R2 is halogen, lower alkyl, or lower alkoxy; A is CO; l is 0 or 1; Y is lower alkylene; n is 0W3; the bond between the 3- and the 4-carbon atoms in the carbostyril skeleton is single or double bond) and its salt.
EXAMPLE: 6-[3-(4-Phenyl-1-piperazingye)propioylamino]-3,4-dihydrocarbostyril.
USE: Antihistaminic agent and central nervous system depressant.
PROCESS: The compound of formula I can be prepared by reacting a novel compound of formula II (X1 is halogen) with a compound of formula III some of which is novel. The compound of formula II is obtained by the reaction of a compound of formula VI with a compound of formula X1-Y-COOH or X2-Y-X1 (X2 is halogen), and the compound of formula III is obtained by the reaction of the compound of formula HN(CH2CH)2OH2 with a compound of formula V.
COPYRIGHT: (C)1981,JPO&Japio
JP12556779A 1979-09-28 1979-09-28 Carbostyril derivative Granted JPS5649364A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12556779A JPS5649364A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12556779A JPS5649364A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS5649364A true JPS5649364A (en) 1981-05-02
JPS628117B2 JPS628117B2 (en) 1987-02-20

Family

ID=14913380

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12556779A Granted JPS5649364A (en) 1979-09-28 1979-09-28 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPS5649364A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60126270A (en) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS61145162A (en) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63301821A (en) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPS6434963A (en) * 1986-03-05 1989-02-06 Otsuka Pharma Co Ltd Carbostyril derivative
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
WO2009025265A1 (en) * 2007-08-21 2009-02-26 Shionogi & Co., Ltd. Piperazine derivative
JP2010528042A (en) * 2007-05-21 2010-08-19 レビバ ファーマシューティカルズ，インコーポレーテッド Composition, synthesis and method of use of quinolinone atypical antipsychotic drugs

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0575006U (en) * 1992-03-19 1993-10-12 アラコ株式会社 Door trim structure

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60126270A (en) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPH0564141B2 (en) * 1983-12-14 1993-09-14 Otsuka Pharma Co Ltd
JPS61145162A (en) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63301821A (en) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd Antiarrhythmic agent
JPS6434963A (en) * 1986-03-05 1989-02-06 Otsuka Pharma Co Ltd Carbostyril derivative
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JP2010528042A (en) * 2007-05-21 2010-08-19 レビバ ファーマシューティカルズ，インコーポレーテッド Composition, synthesis and method of use of quinolinone atypical antipsychotic drugs
WO2009025265A1 (en) * 2007-08-21 2009-02-26 Shionogi & Co., Ltd. Piperazine derivative

Also Published As

Publication number Publication date
JPS628117B2 (en) 1987-02-20

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