JPS6434963A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS6434963A
JPS6434963A JP62049374A JP4937487A JPS6434963A JP S6434963 A JPS6434963 A JP S6434963A JP 62049374 A JP62049374 A JP 62049374A JP 4937487 A JP4937487 A JP 4937487A JP S6434963 A JPS6434963 A JP S6434963A
Authority
JP
Japan
Prior art keywords
compound shown
formula
alkyl
solvent
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62049374A
Other languages
Japanese (ja)
Other versions
JP2576862B2 (en
Inventor
Fujio Tafusa
Kazuyoshi Ei
Yoshinori Tsutsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP62049374A priority Critical patent/JP2576862B2/en
Publication of JPS6434963A publication Critical patent/JPS6434963A/en
Application granted granted Critical
Publication of JP2576862B2 publication Critical patent/JP2576862B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I (R<1> is H, alkyl, alkenyl, phenylalkyl, carboxyalkyl or amidoalkyl; R<2> is azido, carbonylazide, phthalimido, pyridyl or piperidyl; R<3> is alkyl, alkoxy, OH, halogen, carboxy or phenyl; n is 0-3; at least one of R<2> and R<3> is substituted at the 8-position of carbostyril skeleton). EXAMPLE:3-Diethylamino-8-methyl-3,4-dihydrocarbostyril. USE:An antiarrhythmic agent suppressing irritative abnormality occurring in ischemia almost without influencing contractive force of cardiac muscle. PREPARATION:For example, a compound shown by formula II (R<6> and R<7> are alkyl) is subjected to ring formation by reduction in a solvent by using a catalytic reduction catalyst to give a compound shown by formula III, which is then treated in the presence of an acid in the absence of a solvent or in a proper solvent to give a compound shown by formula I wherein R<1> is H.
JP62049374A 1986-03-05 1987-03-04 Carbostyril derivative Expired - Lifetime JP2576862B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62049374A JP2576862B2 (en) 1986-03-05 1987-03-04 Carbostyril derivative

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP4782486 1986-03-05
JP61-47824 1986-03-05
JP22672986 1986-09-25
JP61-226729 1986-09-25
JP62-6758 1987-01-14
JP675887 1987-01-14
JP62049374A JP2576862B2 (en) 1986-03-05 1987-03-04 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS6434963A true JPS6434963A (en) 1989-02-06
JP2576862B2 JP2576862B2 (en) 1997-01-29

Family

ID=27454564

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62049374A Expired - Lifetime JP2576862B2 (en) 1986-03-05 1987-03-04 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JP2576862B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100516383B1 (en) * 2002-01-18 2005-09-22 주식회사 코오롱 New manufacturing process of dihydrocarbostyril derivatives
JP2005533747A (en) * 2002-02-05 2005-11-10 ノボ　ノルディスク　アクティーゼルスカブ Novel aryl and heteroaryl piperazines

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516972A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Amino 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5148675A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd Asetoamido 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152179A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS51125390A (en) * 1975-04-17 1976-11-01 Otsuka Pharmaceut Co Ltd A process for preparing carbostyril derivatives
JPS51149069A (en) * 1975-03-06 1976-12-21 Seiko Epson Corp Electric wrist watch with computer
JPS52137416A (en) * 1976-05-14 1977-11-16 Nippon Kokan Kk Production of concrete mixed with steel fibres
JPS5649363A (en) * 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5649364A (en) * 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777674A (en) * 1980-10-31 1982-05-15 Ishihara Sangyo Kaisha Ltd Phenylurea compound, its preparation, and herbicide containing the same
JPS5883678A (en) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd Preparation of carbostyril derivative
JPS5883677A (en) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5888314A (en) * 1981-11-20 1983-05-26 Otsuka Pharmaceut Co Ltd Cardiac
JPS5929667A (en) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS60126270A (en) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS60209567A (en) * 1984-03-27 1985-10-22 マイルス・ラボラトリーズ・インコーポレーテツド Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator
JPS6115875A (en) * 1984-06-26 1986-01-23 メルク　エンド　カムパニー　インコーポレーテツド Lactam compound ring condensed with benzene ring useful as cholecystokinin antagonist

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516972A (en) * 1974-07-08 1976-01-20 Otsuka Pharma Co Ltd Amino 3*44 jihidorokarubosuchirirujudotaino seizoho
JPS5148675A (en) * 1974-10-17 1976-04-26 Otsuka Pharma Co Ltd Asetoamido 3 44 jihidorokarubosuchirirujudotaino seizoho
JPS5152179A (en) * 1974-10-31 1976-05-08 Otsuka Pharma Co Ltd KARUBOSUCHIRIRU JUDOTAINO SEIZOHO
JPS51149069A (en) * 1975-03-06 1976-12-21 Seiko Epson Corp Electric wrist watch with computer
JPS51125390A (en) * 1975-04-17 1976-11-01 Otsuka Pharmaceut Co Ltd A process for preparing carbostyril derivatives
JPS52137416A (en) * 1976-05-14 1977-11-16 Nippon Kokan Kk Production of concrete mixed with steel fibres
JPS5649363A (en) * 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5649364A (en) * 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777674A (en) * 1980-10-31 1982-05-15 Ishihara Sangyo Kaisha Ltd Phenylurea compound, its preparation, and herbicide containing the same
JPS5883678A (en) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd Preparation of carbostyril derivative
JPS5883677A (en) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5888314A (en) * 1981-11-20 1983-05-26 Otsuka Pharmaceut Co Ltd Cardiac
JPS5929667A (en) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS60126270A (en) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS60209567A (en) * 1984-03-27 1985-10-22 マイルス・ラボラトリーズ・インコーポレーテツド Fluorescent dihydroquinone and dihydrocoumarin hydrogen peroxide indicator
JPS6115875A (en) * 1984-06-26 1986-01-23 メルク　エンド　カムパニー　インコーポレーテツド Lactam compound ring condensed with benzene ring useful as cholecystokinin antagonist

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100516383B1 (en) * 2002-01-18 2005-09-22 주식회사 코오롱 New manufacturing process of dihydrocarbostyril derivatives
JP2005533747A (en) * 2002-02-05 2005-11-10 ノボ　ノルディスク　アクティーゼルスカブ Novel aryl and heteroaryl piperazines

Also Published As

Publication number Publication date
JP2576862B2 (en) 1997-01-29

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