JPS5616474A - 5-fluorouracil derivative - Google Patents

5-fluorouracil derivative

Info

Publication number
JPS5616474A
JPS5616474A JP9045379A JP9045379A JPS5616474A JP S5616474 A JPS5616474 A JP S5616474A JP 9045379 A JP9045379 A JP 9045379A JP 9045379 A JP9045379 A JP 9045379A JP S5616474 A JPS5616474 A JP S5616474A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
compound
lower acyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9045379A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Kikuo Wakizaka
Seiji Haga
Yasuo Nagamatsu
Taiji Okada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP9045379A priority Critical patent/JPS5616474A/en
Publication of JPS5616474A publication Critical patent/JPS5616474A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:5-Fluorouracil derivatives of formula I (R1 is H, lower acyl; R2 is lower alkyl, aryl, aralky).
EXAMPLE: 1-Acety1-3-carbobenzoxy-5-fluorouracil.
USE: Carcinostatic: they have high antitumorigenic activity.
PREPARATION: For example, the reaction of an N1-acy1-5-fluorouracil derivative of formula II (R3 is lower acyl) with a halogen compound of formula X-COOR2 (X is halogen) afford the compound of formula I where R1 is lower acyl. The compound bearing H as R1 is obtained by treating it in a protonic solvent.
COPYRIGHT: (C)1981,JPO&Japio
JP9045379A 1979-07-18 1979-07-18 5-fluorouracil derivative Pending JPS5616474A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9045379A JPS5616474A (en) 1979-07-18 1979-07-18 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9045379A JPS5616474A (en) 1979-07-18 1979-07-18 5-fluorouracil derivative

Publications (1)

Publication Number Publication Date
JPS5616474A true JPS5616474A (en) 1981-02-17

Family

ID=13999031

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9045379A Pending JPS5616474A (en) 1979-07-18 1979-07-18 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS5616474A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794384B1 (en) 1998-02-12 2004-09-21 De Montfort University Hydroxylation activated drug release

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794384B1 (en) 1998-02-12 2004-09-21 De Montfort University Hydroxylation activated drug release

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